Pub Date : 2022-10-02DOI: 10.22627/2072-8107-2022-21-3-52-55
E. A. Gashina, E. Lobova, E. P. Shefer
The ongoing pandemic of the new coronavirus infection allows us to discover new information concerning the clinical course of the disease. Despite the rarer registration and mild course of COVID-19 in children, we get new data on more severe manifestations in the form of damage to various organs including cardiovascular system. SARS-CoV-2 can lead to myocarditis development, arrhythmia, heart failure, etc.According to an infectious diseases hospital in Omsk, heart changes were recorded in 5.8% of hospitalized children with COVID-19. The article presents a clinical case of the new coronavirus infection in a child of 15 years old who was on treatment in the infection diseases hospital of Budgetary Healthcare Institution of Omsk Oblast City Children's Clinical Hospital №3 of Omsk. The diagnosis was confirmed by examining nasopharyngeal smears for evidence of RNA SARS-CoV-2 by PCR. The course of infection in this patient is characterized by myocarditis development following medium severity disease without comorbid pathology.
{"title":"A clinical case of the new coronavirus infection with cardiac involvement in a child","authors":"E. A. Gashina, E. Lobova, E. P. Shefer","doi":"10.22627/2072-8107-2022-21-3-52-55","DOIUrl":"https://doi.org/10.22627/2072-8107-2022-21-3-52-55","url":null,"abstract":"The ongoing pandemic of the new coronavirus infection allows us to discover new information concerning the clinical course of the disease. Despite the rarer registration and mild course of COVID-19 in children, we get new data on more severe manifestations in the form of damage to various organs including cardiovascular system. SARS-CoV-2 can lead to myocarditis development, arrhythmia, heart failure, etc.According to an infectious diseases hospital in Omsk, heart changes were recorded in 5.8% of hospitalized children with COVID-19. The article presents a clinical case of the new coronavirus infection in a child of 15 years old who was on treatment in the infection diseases hospital of Budgetary Healthcare Institution of Omsk Oblast City Children's Clinical Hospital №3 of Omsk. The diagnosis was confirmed by examining nasopharyngeal smears for evidence of RNA SARS-CoV-2 by PCR. The course of infection in this patient is characterized by myocarditis development following medium severity disease without comorbid pathology.","PeriodicalId":9855,"journal":{"name":"CHILDREN INFECTIONS","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74793601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-02DOI: 10.22627/2072-8107-2022-21-3-39-46
T. Chernova, V. N. Timchenko, E. B. Pavlova, E. V. Baracina, M. Subbotina
Parvovirus B19 infection is best known as erythema infectiosum. However, infection with parvovirus B19 can lead to damage to various organs and systems, the development of severe complications up to death. The infection is most dangerous for people with immunodeficiency and hematological diseases. Serious consequences are possible with intrauterine infection of the fetus. Knowledge about the characteristics of the pathogen, the pathogenesis of the disease, the variety of clinical manifestations will allow the doctor to avoid diagnostic errors and provide the patient with timely medical care.
{"title":"Parvovirus В19 infection: lecture","authors":"T. Chernova, V. N. Timchenko, E. B. Pavlova, E. V. Baracina, M. Subbotina","doi":"10.22627/2072-8107-2022-21-3-39-46","DOIUrl":"https://doi.org/10.22627/2072-8107-2022-21-3-39-46","url":null,"abstract":"Parvovirus B19 infection is best known as erythema infectiosum. However, infection with parvovirus B19 can lead to damage to various organs and systems, the development of severe complications up to death. The infection is most dangerous for people with immunodeficiency and hematological diseases. Serious consequences are possible with intrauterine infection of the fetus. Knowledge about the characteristics of the pathogen, the pathogenesis of the disease, the variety of clinical manifestations will allow the doctor to avoid diagnostic errors and provide the patient with timely medical care.","PeriodicalId":9855,"journal":{"name":"CHILDREN INFECTIONS","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72836586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-02DOI: 10.22627/2072-8107-2022-21-3-22-27
R. F. Sayfullin, N. Zvereva, M. A. Sayfullin, S. Smetanina, E. V. Kardonova, O. Shamsheva
In the treatment of Lyme borreliosis (LB), early diagnosis is a key component. The epidemiological history of the patient plays one of the leading roles in suspected borreliosis and at the same time is an important criterion for clinical diagnosis.Purpose. Analysis of epidemiological history data in outpatient cases of LB in Moscow.Material and methods. We conducted a retrospective, non-randomized, single-center cohort study, based on the analysis of data from 660 outpatient records of patients, referred by local physician with tick bite or suspicion of LB, and consulted by an infectious disease specialist on the basis of the Infectious clinical hospital No.1 in Moscow. For further analysis, patients were divided by age and the presence or absence of LB. Confirmation of LB was based on clinical and/or laboratory criteria using methods of enzyme immunoassay and immune blot.Results. We have updated the epidemiological features of the LB for Moscow, such as: the relative number of cases in the administrative districts of Moscow, places and seasonality of tick bites. Among children, compared with adults, cases of a tick bite without the development of LB was predominant, which must be taken into account in order to avoid overdiagnosis of LB. In patients with LB, an indication of the fact of tick bite in the anamnesis was much less common than going to its habitats.Conclusion. Our data clarify the epidemiological features of LB for residents of Moscow. In the absence of a history of indications of tick bite, an informative sign for clinical diagnosis is a visit to its habitats, including not only trips to wooded areas, but also to suburban areas and parks.
{"title":"Features of the epidemiological history of patients with Lyme borreliosis","authors":"R. F. Sayfullin, N. Zvereva, M. A. Sayfullin, S. Smetanina, E. V. Kardonova, O. Shamsheva","doi":"10.22627/2072-8107-2022-21-3-22-27","DOIUrl":"https://doi.org/10.22627/2072-8107-2022-21-3-22-27","url":null,"abstract":"In the treatment of Lyme borreliosis (LB), early diagnosis is a key component. The epidemiological history of the patient plays one of the leading roles in suspected borreliosis and at the same time is an important criterion for clinical diagnosis.Purpose. Analysis of epidemiological history data in outpatient cases of LB in Moscow.Material and methods. We conducted a retrospective, non-randomized, single-center cohort study, based on the analysis of data from 660 outpatient records of patients, referred by local physician with tick bite or suspicion of LB, and consulted by an infectious disease specialist on the basis of the Infectious clinical hospital No.1 in Moscow. For further analysis, patients were divided by age and the presence or absence of LB. Confirmation of LB was based on clinical and/or laboratory criteria using methods of enzyme immunoassay and immune blot.Results. We have updated the epidemiological features of the LB for Moscow, such as: the relative number of cases in the administrative districts of Moscow, places and seasonality of tick bites. Among children, compared with adults, cases of a tick bite without the development of LB was predominant, which must be taken into account in order to avoid overdiagnosis of LB. In patients with LB, an indication of the fact of tick bite in the anamnesis was much less common than going to its habitats.Conclusion. Our data clarify the epidemiological features of LB for residents of Moscow. In the absence of a history of indications of tick bite, an informative sign for clinical diagnosis is a visit to its habitats, including not only trips to wooded areas, but also to suburban areas and parks.","PeriodicalId":9855,"journal":{"name":"CHILDREN INFECTIONS","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73023422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-02DOI: 10.22627/2072-8107-2022-21-3-56-60
S. M. Bezrodnova, N. A. Yatsenkо, G. M. Sirazhov, Yu. N. Kashina
Children are more likely to have asymptomatic and mild forms of novel coronavirus infection, as well as a more favorable outcome of the disease compared to adult patients. Children account for about 15% of all cases of COVID-19 recorded in the country. There are more and more reports of severe and even fatal cases of a new coronavirus infection in children. The development of severe forms of COVID-19 is typical for children at risk. Of particular interest are special groups of pediatric patients, such as children with immunodeficiencies of various etiologies.A clinical case of a new coronavirus infection with a fatal outcome in a 10-year-old child with severe secondary immunodeficiency associated with hematopoietic stem cell transplantation against the background of acute lymphoblastic leukemia is presented.
{"title":"New coronavirus infection in a child with severe secondary immunodeficiency associated with hematopoietic stem cell transplantation against the background of acute lymphoblastic leukemia","authors":"S. M. Bezrodnova, N. A. Yatsenkо, G. M. Sirazhov, Yu. N. Kashina","doi":"10.22627/2072-8107-2022-21-3-56-60","DOIUrl":"https://doi.org/10.22627/2072-8107-2022-21-3-56-60","url":null,"abstract":"Children are more likely to have asymptomatic and mild forms of novel coronavirus infection, as well as a more favorable outcome of the disease compared to adult patients. Children account for about 15% of all cases of COVID-19 recorded in the country. There are more and more reports of severe and even fatal cases of a new coronavirus infection in children. The development of severe forms of COVID-19 is typical for children at risk. Of particular interest are special groups of pediatric patients, such as children with immunodeficiencies of various etiologies.A clinical case of a new coronavirus infection with a fatal outcome in a 10-year-old child with severe secondary immunodeficiency associated with hematopoietic stem cell transplantation against the background of acute lymphoblastic leukemia is presented.","PeriodicalId":9855,"journal":{"name":"CHILDREN INFECTIONS","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74353473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-20DOI: 10.22627/2072-8107-2022-21-2-38-45
D. D. Demchenko, K. Ermolenko, Y. Lobzin, I. Narkevich, O. D. Nemyatykh, V. N. Timchenko, Yu. V. Matlashevskaya
The paper analyzes approaches to etiotropic therapy and structural assessment of the range of drugs for the treatment of campylobacteriosis in children. The methods of content analysis, grouping, data aggregation, comparative and marketing analysis were used. The information base of the study was the State Register of Medicines, federal clinical guidelines for the provision of medical care to children with campylobacteriosis, European and American clinical guidelines, as well as instructions for the medical use of drugs.Comparative analysis showed that Russian clinical guidelines contain 15 international non-proprietary names used for the etiotropic therapy of campylobacteriosis. The analysis carried out by drug producing countries shows that the leading positions in the supply structure are occupied by Russian producers (68.26%). Structuring by dosage forms makes it possible to single out tablet positions (47.46%). At the same time, 36.47% of the range of drugs are approved for use from the age of 12, which limits the implementation of modern approaches to the rational etiotropic therapy of campylobacteriosis in pediatrics. Structural analysis of the range of pharmaceutical substances identifies a significant contribution to the structure of imports of Chinese producers (46.30%), which, in turn, justifies the prospects for import substitution. Solving the problem of improving the quality of medical care for children with campylobacteriosis determines the prospects for further research based on the principles of evidence-based medicine using the tools of mathematical-statistical and pharmacoeconomic analyses.
{"title":"Marketing assessment of the potential of the Russian pharmaceutical market in the framework of etiotropic therapy of children with campylobacteriosis","authors":"D. D. Demchenko, K. Ermolenko, Y. Lobzin, I. Narkevich, O. D. Nemyatykh, V. N. Timchenko, Yu. V. Matlashevskaya","doi":"10.22627/2072-8107-2022-21-2-38-45","DOIUrl":"https://doi.org/10.22627/2072-8107-2022-21-2-38-45","url":null,"abstract":"The paper analyzes approaches to etiotropic therapy and structural assessment of the range of drugs for the treatment of campylobacteriosis in children. The methods of content analysis, grouping, data aggregation, comparative and marketing analysis were used. The information base of the study was the State Register of Medicines, federal clinical guidelines for the provision of medical care to children with campylobacteriosis, European and American clinical guidelines, as well as instructions for the medical use of drugs.Comparative analysis showed that Russian clinical guidelines contain 15 international non-proprietary names used for the etiotropic therapy of campylobacteriosis. The analysis carried out by drug producing countries shows that the leading positions in the supply structure are occupied by Russian producers (68.26%). Structuring by dosage forms makes it possible to single out tablet positions (47.46%). At the same time, 36.47% of the range of drugs are approved for use from the age of 12, which limits the implementation of modern approaches to the rational etiotropic therapy of campylobacteriosis in pediatrics. Structural analysis of the range of pharmaceutical substances identifies a significant contribution to the structure of imports of Chinese producers (46.30%), which, in turn, justifies the prospects for import substitution. Solving the problem of improving the quality of medical care for children with campylobacteriosis determines the prospects for further research based on the principles of evidence-based medicine using the tools of mathematical-statistical and pharmacoeconomic analyses.","PeriodicalId":9855,"journal":{"name":"CHILDREN INFECTIONS","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82393064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-20DOI: 10.22627/2072-8107-2022-21-2-28-33
L. A. Ikkes, G. Martynova
Рurpose: to identify clinical and laboratory criteria that mark the severity of infectious mononucleosis in children, with the identification of risk factors for the development of severe forms and unfavorable course.Patients and methods. A comparative prospective clinical study involved 200 children aged 3 to 11 years with moderate (125 people) and severe (75 people) form of infectious mononucleosis. When comparing clinical and laboratory data in the compared groups, the Mann-Whitney test was used. For multiple comparisons, the Kruskal-Wally test was used. Significance of differences was determined at a significance level of 0.05 (p < 0.05).Results. A comparative analysis of the clinical and laboratory manifestations of infectious mononucleosis revealed statistically significant differences in the studied parameters depending on the severity of the disease. Severe forms of infectious mononucleosis were distinguished by the most pronounced clinical symptoms, as well as changes in hematological parameters and biochemical changes. The combined etiology of infectious mononucleosis also contributed to a more severe course of the disease.Сonclusion. Timely diagnosis and assessment of the severity of the manifest form of infectious mononucleosis determine the adequacy of the appointment of rational antiviral and pathogenetic therapy, preventing the development of adverse effects and complications.
{"title":"Infectious mononucleosis in children: clinical and laboratory criteria for assessing severity","authors":"L. A. Ikkes, G. Martynova","doi":"10.22627/2072-8107-2022-21-2-28-33","DOIUrl":"https://doi.org/10.22627/2072-8107-2022-21-2-28-33","url":null,"abstract":"Рurpose: to identify clinical and laboratory criteria that mark the severity of infectious mononucleosis in children, with the identification of risk factors for the development of severe forms and unfavorable course.Patients and methods. A comparative prospective clinical study involved 200 children aged 3 to 11 years with moderate (125 people) and severe (75 people) form of infectious mononucleosis. When comparing clinical and laboratory data in the compared groups, the Mann-Whitney test was used. For multiple comparisons, the Kruskal-Wally test was used. Significance of differences was determined at a significance level of 0.05 (p < 0.05).Results. A comparative analysis of the clinical and laboratory manifestations of infectious mononucleosis revealed statistically significant differences in the studied parameters depending on the severity of the disease. Severe forms of infectious mononucleosis were distinguished by the most pronounced clinical symptoms, as well as changes in hematological parameters and biochemical changes. The combined etiology of infectious mononucleosis also contributed to a more severe course of the disease.Сonclusion. Timely diagnosis and assessment of the severity of the manifest form of infectious mononucleosis determine the adequacy of the appointment of rational antiviral and pathogenetic therapy, preventing the development of adverse effects and complications.","PeriodicalId":9855,"journal":{"name":"CHILDREN INFECTIONS","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86703321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-20DOI: 10.22627/2072-8107-2022-21-2-46-50
S. B. Chuelov, A. L. Rossina
The urgency of the problem of human cysticercosis is due to the widespread prevalence of this disease, polymorphism and the severity of clinical manifestations. The purpose and result of the work is to summarize the available information about the etiology, epidemiology, clinical picture, diagnosis, and treatment of human cysticercosis.Conclusion. Cysticercosis affects several million people worldwide. The clinic depends on the location of the cysticercus. Diagnostics is carried out on the basis of a morphological study of the obtained biomaterial, instrumental, serological and molecular genetic research methods. Albendazole, praziquantel are used as etiotropic therapy. Surgical removal of cysticercus is performed according to indications.
{"title":"Human Сysticercosis caused by Taenia solium, Taenia crassiceps, Taenia hydatigena, Taenia martis","authors":"S. B. Chuelov, A. L. Rossina","doi":"10.22627/2072-8107-2022-21-2-46-50","DOIUrl":"https://doi.org/10.22627/2072-8107-2022-21-2-46-50","url":null,"abstract":"The urgency of the problem of human cysticercosis is due to the widespread prevalence of this disease, polymorphism and the severity of clinical manifestations. The purpose and result of the work is to summarize the available information about the etiology, epidemiology, clinical picture, diagnosis, and treatment of human cysticercosis.Conclusion. Cysticercosis affects several million people worldwide. The clinic depends on the location of the cysticercus. Diagnostics is carried out on the basis of a morphological study of the obtained biomaterial, instrumental, serological and molecular genetic research methods. Albendazole, praziquantel are used as etiotropic therapy. Surgical removal of cysticercus is performed according to indications.","PeriodicalId":9855,"journal":{"name":"CHILDREN INFECTIONS","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89611186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-20DOI: 10.22627/2072-8107-2022-21-2-57-59
A. V. Bitsueva, S. G. Gorbunov, I. A. Nikulina
The article presents a clinical case of reactivation of chronic Epstein-Barr viral (EBV) infection complicated by the development of hepatitis in a 15-year-old teenager with COVID-19, which is of interest to infectious disease practitioners, pediatricians and other specialists in terms of the clinical course and differential diagnosis of these two viral diseases.It is shown that the reactivation of EBV against the background of the current new coronavirus infection COVID-19, accompanied by an increase in the level of aminotransferases in the blood, leads to a more severe course and prolonged stay of the patient in the hospital, as well as the appointment of additional drug therapy with subsequent rehabilitation measures.
{"title":"A case of reactivation of chronic Epstein-Barr viral infection, complicated by hepatitis, in a teenager with COVID-19","authors":"A. V. Bitsueva, S. G. Gorbunov, I. A. Nikulina","doi":"10.22627/2072-8107-2022-21-2-57-59","DOIUrl":"https://doi.org/10.22627/2072-8107-2022-21-2-57-59","url":null,"abstract":"The article presents a clinical case of reactivation of chronic Epstein-Barr viral (EBV) infection complicated by the development of hepatitis in a 15-year-old teenager with COVID-19, which is of interest to infectious disease practitioners, pediatricians and other specialists in terms of the clinical course and differential diagnosis of these two viral diseases.It is shown that the reactivation of EBV against the background of the current new coronavirus infection COVID-19, accompanied by an increase in the level of aminotransferases in the blood, leads to a more severe course and prolonged stay of the patient in the hospital, as well as the appointment of additional drug therapy with subsequent rehabilitation measures.","PeriodicalId":9855,"journal":{"name":"CHILDREN INFECTIONS","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84642162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-20DOI: 10.22627/2072-8107-2022-21-2-23-27
A. V. Agafonova, V. V. Vasiliev, N. Rogozina
Materials and methods. The features of the course of pregnancy and childbirth, the condition of children at birth, histomorphological conclusions of placentas and the expression of the CD15 marker in the placentas of 40 children with congenital infectious diseases, 10 children with asphyxia at birth and 10 healthy full-term children were analyzed.Results. The analysis showed the absence of reliable clinical and morphological criteria for the risk of developing a congenital infectious disease. Thus, the majority of mothers of children of all comparison groups had various somatic pathology: 33 (82.5%) in group 1, 8 (80%) in group 2, 6 (60%) in group 3 (p ≥ 0.05) Children of all comparison groups were statistically comparable in gestational age, anthropometric data and assessment on the Apgar scale. During histological examination, inflammatory changes in the afterbirth in children of the compared groups were recorded with almost the same frequency: in 17 (42.5%) children with intrauterine infection, 4 (40%) with asphyxia at birth and 2 (20%) healthy children (p ≥ 0.05). At the same time, immunohistochemically, placentas of children with congenital infectious diseases were characterized by a significantly higher level of CD15 expression compared to placentas of healthy children: CD15 expression coefficient in placentas of children with congenital infectious diseases was 6.9 ± 0.9, in the group of healthy children — 0.7 ± 0.5, (p < 0.05).Conclusion. The use of the immunohistochemical marker CD15 makes it possible to predict congenital infectious disease in newborns in the absence of obvious morphological signs of an infectious lesion of the afterbirth, and can be used to form risk groups for the implementation of infectious pathology.
{"title":"Clinical and morphological characteristics of placentas of full-term infants with congenital infectious diseases","authors":"A. V. Agafonova, V. V. Vasiliev, N. Rogozina","doi":"10.22627/2072-8107-2022-21-2-23-27","DOIUrl":"https://doi.org/10.22627/2072-8107-2022-21-2-23-27","url":null,"abstract":"Materials and methods. The features of the course of pregnancy and childbirth, the condition of children at birth, histomorphological conclusions of placentas and the expression of the CD15 marker in the placentas of 40 children with congenital infectious diseases, 10 children with asphyxia at birth and 10 healthy full-term children were analyzed.Results. The analysis showed the absence of reliable clinical and morphological criteria for the risk of developing a congenital infectious disease. Thus, the majority of mothers of children of all comparison groups had various somatic pathology: 33 (82.5%) in group 1, 8 (80%) in group 2, 6 (60%) in group 3 (p ≥ 0.05) Children of all comparison groups were statistically comparable in gestational age, anthropometric data and assessment on the Apgar scale. During histological examination, inflammatory changes in the afterbirth in children of the compared groups were recorded with almost the same frequency: in 17 (42.5%) children with intrauterine infection, 4 (40%) with asphyxia at birth and 2 (20%) healthy children (p ≥ 0.05). At the same time, immunohistochemically, placentas of children with congenital infectious diseases were characterized by a significantly higher level of CD15 expression compared to placentas of healthy children: CD15 expression coefficient in placentas of children with congenital infectious diseases was 6.9 ± 0.9, in the group of healthy children — 0.7 ± 0.5, (p < 0.05).Conclusion. The use of the immunohistochemical marker CD15 makes it possible to predict congenital infectious disease in newborns in the absence of obvious morphological signs of an infectious lesion of the afterbirth, and can be used to form risk groups for the implementation of infectious pathology.","PeriodicalId":9855,"journal":{"name":"CHILDREN INFECTIONS","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75565712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-20DOI: 10.22627/2072-8107-2022-21-2-60-66
A. A. Khamatova, T. A. Chebotareva, J. F. Vlatskaya
HIV infection and HCV infection are still serious and widespread infections that lead to high morbidity and mortality of the population worldwide.The aim is to assess the risks of perinatal transmission of HIV/HCV co-infection and the choice of modern treatment tactics in children.Аnalyzed data in foreign and domestic literature. A clinical case of perinatal transmission of HIV/HCV co-infection is described.Results. Тhe features of perinatal transmission of infection depending on its variants (mono-HIV infection, hepatitis C and co-infection with HIV/HCV) and risk factors are shown. A clinical example demonstrates the implementation of perinatal transmission of HIV/HCV co-infection in the presence of major risk factors. The improvement of therapeutic tactics in a child with co-infection is shown.Conclusion: in the described clinical case, numerous risk factors for perinatal transmission of HIV/HCV co-infection are demonstrated, the presence of which led to the realization of co-infection in a child. The effectiveness of modern tactics for the treatment of HIV infection and chronic viral hepatitis C has been demonstrated.
{"title":"The risks of perinatal HIV/HCV co-infection and the evolution of treatment tactics of the disease in children (clinical case)","authors":"A. A. Khamatova, T. A. Chebotareva, J. F. Vlatskaya","doi":"10.22627/2072-8107-2022-21-2-60-66","DOIUrl":"https://doi.org/10.22627/2072-8107-2022-21-2-60-66","url":null,"abstract":"HIV infection and HCV infection are still serious and widespread infections that lead to high morbidity and mortality of the population worldwide.The aim is to assess the risks of perinatal transmission of HIV/HCV co-infection and the choice of modern treatment tactics in children.Аnalyzed data in foreign and domestic literature. A clinical case of perinatal transmission of HIV/HCV co-infection is described.Results. Тhe features of perinatal transmission of infection depending on its variants (mono-HIV infection, hepatitis C and co-infection with HIV/HCV) and risk factors are shown. A clinical example demonstrates the implementation of perinatal transmission of HIV/HCV co-infection in the presence of major risk factors. The improvement of therapeutic tactics in a child with co-infection is shown.Conclusion: in the described clinical case, numerous risk factors for perinatal transmission of HIV/HCV co-infection are demonstrated, the presence of which led to the realization of co-infection in a child. The effectiveness of modern tactics for the treatment of HIV infection and chronic viral hepatitis C has been demonstrated.","PeriodicalId":9855,"journal":{"name":"CHILDREN INFECTIONS","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85237435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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