中华行为医学与脑科学杂志最新文献

{"title":"The influence of unitization encoding strategy on directed forgetting effect of associative recognition","authors":"Yujuan Wang, Changxing Liu, Bingbing Li","doi":"10.3760/CMA.J.ISSN.1674-6554.2019.12.011","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-6554.2019.12.011","url":null,"abstract":"Objective \u0000To investigate the influence of unitization encoding strategy and the moderating effect of unitization level on directed forgetting effect of associative recognition. \u0000 \u0000 \u0000Methods \u0000Association recognition paradigm combined with directed forgetting paradigm were employed in this study.The 39 participants acquired by simple random sampling were asked to remember or forget compound words or unrelated word pairs which were randomly presented according to cues.In the retrieval stage, they needed to distinguish \" old\" or \" rearranged\" word pairs regardless of the cues. \u0000 \u0000 \u0000Results \u0000(1) The reversed unitization effect reached significance. The discrimination of compound words (0.43±0.03) was lower than that of unrelated words (0.55±0.03) (F=27.27, P<0.001, ηp2=0.42). For the word pairs (to be remembered, TBR), the discrimination of compound words (0.43±0.03) was lower than that of unrelated words (0.59±0.03) (t=-6.05, P<0.001); for the word pairs (to be forgotten, TBF), the discrimination of compound words (0.43±0.03) was still lower than that of unrelated words (0.50±0.04) (t=-2.30, P=0.025). (2) The directed forgetting effect of associative recognition was significant.However, TBR (0.51±0.03) was more discriminative than TBF (0.46±0.03) (F=4.30, P=0.045, ηp2=0.10). But the difference was mainly reflected in the recognition of unrelated words.TBR (0.59±0.03) was more discriminative than TBF (0.50±0.04) (t=3.19, P=0.003). However, there was no significant difference between TBR (0.43±0.03) and TBF (0.43±0.03) in recognition of compound words. \u0000 \u0000 \u0000Conclusion \u0000The unitization encoding stratege can simultaneously promote hit rate and false alarm rate.The directed forgetting effect can be eliminated when unitization level is high enough. \u0000 \u0000 \u0000Key words: \u0000Associative recognition; Directed forgetting; Unitization encoding; Unitization level; Familiarity","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"28 1","pages":"1113-1117"},"PeriodicalIF":0.0,"publicationDate":"2019-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42120739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Event-related potential characteristics analysis on vigilant attention development of school-age children","authors":"Lina Liao, Yang Yi, Chaoqun Wang, Fangqiao Zhao, Yu Dong, Ting Wu","doi":"10.3760/CMA.J.ISSN.1674-6554.2019.11.009","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-6554.2019.11.009","url":null,"abstract":"Objective \u0000To explore the characteristics of event-related potential(ERP) in the development of alert attention of children aged 6-11 years old. \u0000 \u0000 \u0000Methods \u0000A total of 144 children aged 6-11 years old were enrolled in a continuous performance test (CPT, Go/Nogo stimulus task). The latency and amplitude of frontal region cue/uncue-P3 and CNV were analyzed and compared in all age groups. \u0000 \u0000 \u0000Results \u0000(1)Behavioral comparison among different age groups: correct number(35(31, 38), 37(34, 38.25), 37(34.75, 39), 38(35, 39.25), 39(37.25, 40), 39(39, 40)), correct reaction time((566.88±86.63)ms, (530.10±83.40)ms, (509.17±88.99)ms, (488.31±76.23)ms, (463.45±75.78)ms, (417.24±75.78)ms), the differences were statistically significant(P<0.01). (2)Fz lead ERP characteristics: ①Comparison of cue-CNV and uncue-CNV: 6-year-old group((-8.54±4.56)μV vs (-10.13±6.36)μV), 7-year-old group((-9.20±5.34)μV vs (-11.53±4.29)μV), 8-year-old group((-8.37±4.78)μV vs (-11.35±6.38)μV)in amplitude and 9-year-old group((689.25±268.22)ms vs (826.13±174.62)ms)in latency were significantly different(P<0.05). ②Comparison of cue-P3 and uncue-P3: 6-year-old group((4.29±4.11)μV vs (7.45±3.83)μV), 7-year-old group((4.47±4.71)μV vs (5.82±4.40)μV), 8-year-old group((3.76±3.39)μV vs (6.24±4.91)μV), 9-year-old group((4.27±3.57)μV vs (5.93±3.08)μV), 11-year-old group((4.24±4.66)μV vs (6.13±4.42)μV)in amplitude were significantly different(P<0.05). ③Longitudinal comparison among age groups: the latency of cue-CNV in 9-year-old group and 11-year-old group were shorter, and the difference was significant(P<0.05). The amplitudes of cue-CNV and cue-P3 in 10-year-old group were shorter than those in other age groups(P<0.05). \u0000 \u0000 \u0000Conclusion \u0000With the increase of age, the reaction time of school-age children shortened and the correct rate improved.The age of 9-10 may be the high-speed period of the development for brain network on vigilant attention and psychological prediction which may be related to the maturation and development of frontal cortex. \u0000 \u0000 \u0000Key words: \u0000Event related potential; School-age children; Vigilant attention","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"28 1","pages":"1005-1009"},"PeriodicalIF":0.0,"publicationDate":"2019-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46048352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cross-cultural adjustment of successful aging scale and its reliability and validity in urban elderly","authors":"Pei Tong, Jing-Jing Zhou, Yajing Zheng, Qing-Zhuo Ren, Yun-Yi Liang, Qiaoqiao Shen, Xiaojia Sun","doi":"10.3760/CMA.J.ISSN.1674-6554.2019.11.014","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-6554.2019.11.014","url":null,"abstract":"Objective \u0000To revised the Taiwan version successful aging inventory (SAI), and verify its reliability and validity in urban elderly in mainland China. \u0000 \u0000 \u0000Methods \u0000SAI was adjusted by culture and revised by pre-test to form a formal questionnaire. A sample of 600 elderly people in Guangzhou was chosen for a face-to-face questionnaire survey through convenient sampling. Half of the sample (n=300) was randomly selected for exploratory factor analysis, and the other was used to confirm the structural validity of SAI. \u0000 \u0000 \u0000Results \u0000Exploratory factor analysis extracted six common factors, including health autonomy, economic security, life adaptation, society and relative relationship, study and family. The cumulative contribution rate of six common factors was 65.366%. The fitting indexes of confirmatory factor analysis were χ2/df=1.861, CFI=0.930, IFI=0.930, TLI=0.923, GFI=0.823, RMSEA=0.054, RMR=0.073. There were significant ceiling effects in the four dimensions of health autonomy, economic security, life adaptation, and family. The internal consistency coefficient (Cronbach's α) of SAI was 0.930, and the test-retest reliability was 0.943. An average score of SAI ≥ 3.95 points was considered successful aging. \u0000 \u0000 \u0000Conclusion \u0000Reliability and validity of SAI are good, which can be used to measure the successful aging status of Chinese elders and track the effectiveness of health promotion measures. \u0000 \u0000 \u0000Key words: \u0000Successful aging; The elderly; Reliability; Validity","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"28 1","pages":"1030-1036"},"PeriodicalIF":0.0,"publicationDate":"2019-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48096814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of oxygen glucose deprivation and reperfusion on gap junction and glucose uptake of astrocytes","authors":"Xiang-yang Zhang, Cui Wang, W. Guo, Yan Chen","doi":"10.3760/CMA.J.ISSN.1674-6554.2019.11.002","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-6554.2019.11.002","url":null,"abstract":"Objective \u0000To explore the relationship between gap junction and glucose uptake of astrocytes under oxygen-glucose deprivation(OGD) and reperfusion. \u0000 \u0000 \u0000Methods \u0000Cerebral cortical astrocyte from 1 day newborn SD rats were undergone the primary culture. The ischemia cell model was established by OGD. This experiment were divided into control group, OGD group and OGD+ CBX group.After different reperfusion time (0 h, 12 h 24 h and 48 h), the glucose uptake of astrocyte was measured by 2-NBDG through flow cytometry analysis and connexin 43(Cx43) gap junction plaques was detected using immunofluorescene. \u0000 \u0000 \u0000Results \u0000Compared with the control group, the glucose uptake of astrocyte was up-regulated induced by OGD following different reperfusion time.The glucose uptake of OGD group was (2.32±0.43)nmol/μgDNA in 24 hours reperfusion time and was (0.95±0.28)nmol/μgDNA in control group. The up-regulation was up to 2.63-fold increase (t=13.99, P=0.0024) in 24 hours after reperfusion.Compared with the control group, the Cx43 gap junction number was up to 2.5- fold increase(t=11.34, P=0.003) and the size was 1.85-fold increase (t=10.27, P=0.004) in 24 h reperfusion. The glucose uptake of astrocyte after OGD was reduced by CBX and the decrease was 42% in 48 h after reperfusion. \u0000 \u0000 \u0000Conclusion \u0000Those results urges us consider the clinical treatment for interfering with Cx43 gap junction. \u0000 \u0000 \u0000Key words: \u0000Astrocyte; Connexin 43; Gap junction; Oxygen-glucose deprivation; Glucose uptake","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"69 9-10","pages":"967-970"},"PeriodicalIF":0.0,"publicationDate":"2019-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41288022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of brain-specific angiogenesis inhibitor 1 in synapse and cognitive impairment","authors":"Z. Mou, Dan Wang","doi":"10.3760/CMA.J.ISSN.1674-6554.2019.11.017","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-6554.2019.11.017","url":null,"abstract":"Adhesion G protein-coupled receptors(aGPCRs) play a significant role in cognitive impairment related diseases. As an important member of aGPCRs, brain-specific angiogenesis inhibitor 1(BAI1) has a prominent impact on anti-angiogenesis, anti-tumor and participating in immune phagocytosis. Recent research found out that BAI1 exerts a great influence on synaptogenesis and synaptic plasticity, but few studying concerning BAI1 in nervous system. Nowadays, the aging of population aggravates the occurrence of cognitive impairment. The pathogenesis of Alzheimer's disease and vascular cognitive impairment remains elusive, and identification of cognitive impairment at an early stage faces challenges. In the stage of mild cognitive impairment, synaptic damage is evident. BAI1 can regulate the function of postsynaptic membrane, synaptogenesis, synaptic signal transmission and the morphological development of dendritic spines. Therefore, it may potentially act as an early-warning index and intervention target for cognitive impairment. \u0000 \u0000 \u0000Key words: \u0000Brain-specific angiogenesis inhibitor 1; Cognitive impairment; Adhesion G protein-coupled receptors; Synaptogenesis; Mild cognitive impairment","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"28 1","pages":"1048-1051"},"PeriodicalIF":0.0,"publicationDate":"2019-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42772529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The abnormal cognitive function and neural mechanism of individuals with internet gaming disorder","authors":"Fangfang Chen, C. Gu, C. Cai","doi":"10.3760/CMA.J.ISSN.1674-6554.2019.11.018","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-6554.2019.11.018","url":null,"abstract":"Internet gaming disorder (IGD) refers to individuals who are extremely dependent on online games and can’t control the game time reasonably.Generally, individuals with IGD also display withdrawal symptoms when they do not play games.Combined with previous studies, this paper discussed the cognitive dysfunction and neural mechanisms of IGD individuals, including executive function, reward system and emotional regulation dysfunction.First of all, executive function is a high-level cognitive processing ability that involves cognitive and behavioral processes.Cognitive control is often associated with the individual's goal-directed behavior and the ability to flexibly apply the high-level cognitive function. Repeated and excessive game behaviors of IGD individuals may be associated with their abnormal cognitive control and decision-making functions. And the attention process as another important component of executive function. The persistent addictive behavior in individuals with IGD were associated with a bias toward attention to game-related cues.Also, IGD individuals show differences in executive function abnormalities such as decision-making and dominance response inhibition, suggesting that there is a separation between \"cold\" and \"hot\" executive function abnormalities, and this feature may also be associated with other cognitive dysfunctions. Secondly, reward incentives play an important role in individual motivational learning and goal-oriented behavior. The increased sensitivity of IGD individuals to reward stimuli in various types of reward and punishment stimuli suggests that their reward system is abnormal.Finally, emotional regulation is an important cognitive function that is closely related to executive function. The anxiety and depression manifested by IGD individuals are often associated with their inability to apply emotional regulation strategies flexibly. It is difficult for individuals with IGD applied emotional regulation strategies flexibly, and inappropriate emotional regulation strategies and emotional responses suggest abnormal mood regulation. To sum up, cognitive dysfunction was not only the basis of IGD addiction symptoms, but also one of the important factors of its symptom maintenance. In addition, the further research prospects included expanded sampling population, deepening neural mechanism research and physical intervention are proposed for the lack of previous research in the last part of the article. \u0000 \u0000 \u0000Key words: \u0000Internet gaming disorder; Executive function; Rewarding system; Emotional regulation","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"28 1","pages":"1052-1056"},"PeriodicalIF":0.0,"publicationDate":"2019-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45723244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Path analysis of self-efficacy, coping style and social support on resilience in patients with chronic hepatitis B","authors":"W. Xiao, Zhang Aidi, Yan Jin, Liu Yan, Long Feiyan","doi":"10.3760/CMA.J.ISSN.1674-6554.2019.11.006","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-6554.2019.11.006","url":null,"abstract":"Objective \u0000To explore the mediating, direct and indirect roles of self-efficacy, social support and medical coping modes with resilience in patients with chronic hepatitis B. \u0000 \u0000 \u0000Methods \u0000Totally 384 inpatients and outpatients with chronic hepatitis B, without physical ailments or mental problems were selected.The Connor-Davidson resilience scale (CD-RISC), general self-efficacy scale (GSES), medical coping modes questionnaire (MCMQ) and social support rating scale (SSRS) were adopted in this research.The relationship among all variables was explored by path analysis. \u0000 \u0000 \u0000Results \u0000(1)The total scores of resilience, self-efficacy, social support, confrontation, avoidance and acceptance-resignation in chronic hepatitis B patients were (61.64±15.36), (25.40±5.70), (39.82±7.39), (19.02±3.72), (16.63±2.69) and (8.45±2.94), respectively.(2)Pearson analysis showed that the scores of self-efficacy, medical coping and social support were significantly correlated with resilience(r=-0.26-0.82, P<0.05). (3)Importantly, path analysis showed that self-efficacy(β=0.53), confrontation(β=0.10), avoidance(β=0.17) and acceptance-resignation(β=-0.13) had direct prediction effects on resilience.Additionally, self-efficacy was indirectly related to resilience(β=0.05), and social support also indirectly related to resilience through self-efficacy, confrontation and acceptance-resignation(β=0.18). \u0000 \u0000 \u0000Conclusion \u0000Self-efficacy, social support and medical coping are the important factors which play a direct or indirect role in resilience. \u0000 \u0000 \u0000Key words: \u0000Chronic hepatitis B; Resilience; Self-efficacy; Medical coping; Social support; Path analysis","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"28 1","pages":"988-993"},"PeriodicalIF":0.0,"publicationDate":"2019-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46128822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroprotective effects of Ghrelin on traumatic brain injury in mice","authors":"Xuefei Shao, Lei Zhu, T. Yi, Bo Li, Shi-Xiang Cheng","doi":"10.3760/CMA.J.ISSN.1674-6554.2019.11.004","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-6554.2019.11.004","url":null,"abstract":"Objective \u0000To investigate the neuroprotective effect of Ghrelin on traumatic brain injury (TBI) in mice. \u0000 \u0000 \u0000Methods \u0000TBI model of C57BL / 6 mice was established by electronic cortical impact instrument (eCCI). According to the random figure table method, twenty-four mice were randomly divided into sham group(Sham group), TBI group and Ghrelin intervention group(Ghrelin group) with 8 mice in each group. The model of TBI was established in TBI group and Ghrelin group.The mice in Ghrelin group was injected intraperitoneally 0.5 g/kg before and 1 h after injury respectively. And the mice Sham group and TBI group were injected with the same amount of normal saline. The changes of cerebral blood perfusion (CBP) were monitored in real time by laser speckle contrast analysis(LSCI), the changes of neuroelectrophysiology were observed by monitoring motor evoked potential (MEP), and the status of neurological deficit was evaluated by modified neurological deficit score (mNSS). \u0000 \u0000 \u0000Results \u0000Compared with Sham group, the mice in TBI group had significantly lower cerebral blood perfusion(CBP) (t=-12.36, P<0.01), longer latency and lower amplitude of motor evoked potential (MEP) (t=5.03, -11.55, all P<0.01), and significantly higher mNSS scores (t=9.34, P<0.01). However, compared with the TBI group, the cerebral blood perfusion(CBP) of Ghrelin group increased significantly at 12 h after TBI((196.87±17.36) PU/mm2vs (123.62±8.04)PU/mm2, t=10.45, P<0.01), while the latency of MEP decreased((5.30±0.33)ms vs (6.80±0.97)ms, t=-5.01, P<0.01), the amplitude of MEP increased((2.21±0.16)mV vs (1.27±0.27)mV, t=9.65, P<0.01). And compared with the TBI group, the neurological deficit score of Ghrelin group decreased significantly at 24 h after TBI((4.9±1.2) vs (8.4±2.6), t=-3.87, P<0.01). \u0000 \u0000 \u0000Conclusion \u0000Ghrelin exhibits a significant neuroprotective role by increasing cerebral blood flow perfusion, reducing the degree of neurological deficit and promoting motor function recovery in TBI mice. \u0000 \u0000 \u0000Key words: \u0000Traumatic brain injury; Ghrelin; Cerebral blood perfusion; Motor evoked potential; Neuroprotection; Mice","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"28 1","pages":"978-982"},"PeriodicalIF":0.0,"publicationDate":"2019-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49619787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The relationship of peripheral blood single uncoding RNA-25-3p expression level and the sertraline efficacy in patients with panic disorder","authors":"Wenjiao Min, Chenghui Yang, Shuya Pan, Yaoying Zhang, Ying He","doi":"10.3760/CMA.J.ISSN.1674-6554.2019.11.007","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-6554.2019.11.007","url":null,"abstract":"Objective \u0000To identify potential relationship between single uncoding RNA-25-3p (miR-25-3p) expression level and the sertraline efficacy in patients with panic disorder. \u0000 \u0000 \u0000Methods \u0000Sixty cases of patients with panic disorder(case group) and sixty healthy-controls(control group) were collected with demographic data and peripheral venous blood before and after treatment.All the patients were evaluated using the 14-item Hamilton Anxiety Rating Scale (HAMA) and Panic Disorder Severity Scale (PDSS) at baseline, and then received sertraline treatment for 6 weeks.After six-week treatment, each patient was evaluated again with HAMA and PDSS.RT-PCR was used to detect the level of miR-25-3p expression. \u0000 \u0000 \u0000Results \u0000There was no significant difference in the miR-25-3p levels between control group (1.27±0.32) and case group (1.73±1.09) before treatment(t=1.53, P=0.14), but the levels in case group were much higher than that in control group after the treatment (5.72±4.13 vs 1.73±1.09, t=-2.15, P=0.04). Besides, the changes of the miR-25-3p levels were positively related with both the changes of PDSS3 and PDSS7 items before and after the treatment (r=0.60, P=0.02 for PDSS3 and r=0.61, P=0.02 for PDSS7). \u0000 \u0000 \u0000Conclusions \u0000miR-25-3p is associated with the drug efficacy and the outcome of some clinical symptoms of panic disorder.These findings might provide some evidence for the individualized treatment of patients with panic disorder according to regulation of gene expression in the future. \u0000 \u0000 \u0000Key words: \u0000Panic disorder; miR-25-3p; Sertraline; Effect","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"28 1","pages":"994-998"},"PeriodicalIF":0.0,"publicationDate":"2019-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48852531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between emotional problems and coping styles in mothers of children with autism spectrum disorders","authors":"Wensu Zhou, Huilan Xu, Dan Liu, Xiyue Xiong","doi":"10.3760/CMA.J.ISSN.1674-6554.2019.11.011","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1674-6554.2019.11.011","url":null,"abstract":"Objective \u0000To investigate the status of depression and anxiety symptoms in mothers with autistic child, and explore the association between coping styles and emotional problems.To provide theoretical evidence of mental health intervention for mothers with autistic children. \u0000 \u0000 \u0000Methods \u0000A cross-section study was conducted in three autism rehabilitation centres of Changsha city.A total of 135 mothers of autistic child were recruited from March to November 2018.The self-designed questionnaires, patient health questionnaire-9 (PHQ-9), generalized anxiety disorder scale-7 (GAD-7), simple coping style questionnaire(SCSQ) and autism behaviour checklist(ABC) were used in the study.Spearman analysis was used to explore the correlation between emotional problems and copying styles.The ordinal logistic regression was conducted to explore the impact of the coping styles for emotional problems. \u0000 \u0000 \u0000Results \u0000The scores of anxiety and depression symptoms were 9.0 (5.0, 13.0) and 7.0 (3.0, 11.0), respectively.The occurrence rate of anxiety and depression symptoms was 44.5% and 28.1%, respectively.The scores of positive and negative coping were (1.75±0.90) and (1.05±1.03), respectively.There were 72 (53.3%) and 63 (46.7%) of participants adopted positive and negative coping styles, respectively.There was a positive correlation between negative coping and anxiety symptoms (r=0.182, P<0.05). There was a negative correlation between positive coping and depression symptoms (r=-0.184, P<0.05). The ordinal logistic regression showed positive coping was a protective factor for anxiety symptoms (OR=0.444, 95%CI: 0.205-0.965). \u0000 \u0000 \u0000Conclusion \u0000The anxiety and depression symptoms are common problems in mothers of children with ASD.It is necessary to take suitable psychological interventions to encourage them to adopt positive copying styles. \u0000 \u0000 \u0000Key words: \u0000Autism spectrum disorder; Anxiety; Depression; Coping styles","PeriodicalId":9940,"journal":{"name":"Chinese Journal of Behavioral Medicine and Brain Science","volume":"28 1","pages":"1015-1019"},"PeriodicalIF":0.0,"publicationDate":"2019-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43421609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}