Pharmacological Research - Natural Products最新文献_第7页

Quercetin and its derivatives as potent inhibitors of PilA protein of Streptococcus sanguinis: An in silico approach to combat infective endocarditis 槲皮素及其衍生物作为血链球菌PilA蛋白的有效抑制剂：对抗感染性心内膜炎的计算机方法

Pharmacological Research - Natural Products

Pub Date : 2026-01-05 DOI: 10.1016/j.prenap.2026.100496

Bibhu Prasad Rath , Aurobinda Rout , Snehasish Mishra , Chandana Mohanty

Streptococcus sanguinis (S. sanguinis) is a leading cause of infective endocarditis (IE) that cause a wide range of clinical manifestations including death. It utilizes the PilA protein (a key component of type IV pili) to mediate strong adhesion and biofilm formation in heart tissues. Such biofilms exhibit resistance to traditional antibiotics like penicillin G and vancomycin. The standard treatment with these antibiotics are often ineffective owing to poor biofilm penetration leading to persistent infection and antibiotic resistance. Therefore, targeting PilA offers a potential strategy for disrupting biofilm formation and enhancement of IE treatment. The present in silico study is designed to evaluate Quercetin and its derivatives as a safer and alternative strategy to combat S. sanguinis-mediated biofilm formation. Molecular docking analyses demonstrated that Quercetin (-6.5 kcal/mol) and 8-prenylquercetin (-6.6 kcal/mol) exhibited stronger binding to the PilA protein of S. sanguinis compared to Penicillin G (-6.5 kcal/mol), indicating their superior potential in disrupting biofilm formation. Dynamic simulation further confirmed the stability of these complexes over time, suggesting persistent interaction with the target site. Pharmacokinetic evaluation also revealed favourable absorption, distribution, and metabolic properties, while toxicity prediction showed minimal adverse effects. Overall, the study highlights that Quercetin and its derivatives may serve as promising antibiofilm candidates against S. sanguinis. However, experimental validation through in vitro and in vivo studies is warranted to confirm their biological efficacy and safety.

血链球菌（S. sanguinis）是感染性心内膜炎（IE）的主要原因，可引起包括死亡在内的广泛临床表现。它利用PilA蛋白（IV型菌毛的关键成分）介导心脏组织的强粘附和生物膜形成。这种生物膜对青霉素G和万古霉素等传统抗生素具有耐药性。由于生物膜渗透性差，导致持续感染和抗生素耐药性，这些抗生素的标准治疗往往无效。因此，靶向PilA提供了破坏生物膜形成和增强IE治疗的潜在策略。目前的硅研究旨在评估槲皮素及其衍生物作为一种更安全的替代策略来对抗血葡萄球菌介导的生物膜形成。分子对接分析表明，槲皮素（-6.5 kcal/mol）和8-烯基槲皮素（-6.6 kcal/mol）比青霉素G（-6.5 kcal/mol）与血葡萄球菌PilA蛋白的结合更强，表明它们在破坏生物膜形成方面具有更强的潜力。动态模拟进一步证实了这些复合物随时间的稳定性，表明与目标位点的持续相互作用。药代动力学评价也显示了良好的吸收、分布和代谢特性，而毒性预测显示最小的不良反应。总之，该研究强调槲皮素及其衍生物可能作为抗血葡萄球菌的有前途的抗生素候选物。然而，通过体外和体内研究的实验验证是必要的，以确认其生物学有效性和安全性。

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引用次数: 0

Honey-induced rejuvenation: Exploring anti-aging effects and stem cell proliferation in human dental pulp stem cells 蜂蜜诱导的返老还童：探索人类牙髓干细胞的抗衰老作用和干细胞增殖

Pharmacological Research - Natural Products

Pub Date : 2026-01-05 DOI: 10.1016/j.prenap.2026.100493

Mayuri Bapu Chavan , Ajay Kale , Avinash Kharat , Deepak Chandra Joshi , Payal Pawar , Ramesh Bhonde , Diksha Jindal

Background

Human dental pulp stem cells (hDPSCs) hold significant potential for regenerative therapies because of their capacity to differentiate into multiple cell lineages. However, their application is limited by cellular senescence during expansion in vitro. Honey is an organic product that is known for its pharmacological properties and antioxidant. The effects of honey on anti-aging, proliferation, and cell cycle in human dental pulp stem cells (hDPSCs) have not yet been investigated. This study aimed to explore the impact of honey on cell proliferation and senescence using hDPSC as a platform for screening.

Methods

DPSCs were treated with honey-supplemented cell culture media to investigate its effects on cellular senescence and proliferation. DPSC proliferation was measured using the MTT assay and cell cycle analyses. Beta-galactosidase senescence assay was used to detect senescence.

Results

Honey-supplemented culture media increased DPSC proliferation significantly, as evidenced by MTT assay. Cell cycle analysis indicated an increase in the G2/M phase, preventing DPSCs from entering cell cycle arrest phase. Furthermore, honey at a concentration of 0.5 % reduced the number of senescent-positive cells, as confirmed by beta-galactosidase senescence assay.

Conclusion

Our results demonstrate that honey enhances cell proliferation, regulates the cell cycle by preventing DPSCs from cell cycle arrest, and delays senescence in DPSCs. Overall, this study shows that honey is safe, cost-effective, and has anti-senescence activity in hDPSCs.

人类牙髓干细胞（hDPSCs）具有分化为多种细胞系的能力，因此在再生治疗方面具有巨大的潜力。然而，它们的应用受到体外扩增过程中细胞衰老的限制。蜂蜜是一种有机产品，以其药理特性和抗氧化剂而闻名。蜂蜜对人牙髓干细胞（hDPSCs）的抗衰老、增殖和细胞周期的影响尚未被研究。本研究旨在以hDPSC为筛选平台，探讨蜂蜜对细胞增殖和衰老的影响。方法采用添加蜂蜜的细胞培养基处理sdpscs，观察其对细胞衰老和增殖的影响。采用MTT法和细胞周期法测定DPSC增殖。采用-半乳糖苷酶衰老法检测衰老。结果MTT法证实，添加蜂蜜的培养基能显著提高DPSC的增殖能力。细胞周期分析显示G2/M期增加，阻止DPSCs进入细胞周期阻滞期。此外，通过β -半乳糖苷酶衰老试验证实，浓度为0.5 %的蜂蜜减少了衰老阳性细胞的数量。结论蜂蜜可促进细胞增殖，通过防止DPSCs细胞周期阻滞来调节细胞周期，延缓DPSCs衰老。总的来说，这项研究表明蜂蜜是安全的，具有成本效益，并且在hdpsc中具有抗衰老活性。

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引用次数: 0

Analysis of global research trends in essential oils: A bibliometric study of the top 100 most cited articles in the scopus database 全球精油研究趋势分析：scopus数据库中引用次数最多的前100篇文章的文献计量学研究

Pharmacological Research - Natural Products

Pub Date : 2026-01-03 DOI: 10.1016/j.prenap.2026.100488

Baby Gargi , Pooja Singh , Sakshi Painuli , Shabaaz Begum , Jigisha Anand , Prabhakar Semwal , Haroon Khan

Globally, essential oils (EOs) have been established in the spotlight because of their adaptability and the growing interest of consumers. Citations indeed represent the most significant contributions made in a specific field. With this concern, we performed a bibliometric analysis to describe the 100 most cited articles about plant-derived EOs. The relevant information was retrieved from the Scopus database and scrutinized manually. The selected data was then analyzed and visualized through Microsoft Excel, Bibliometrix and VOSviewer software. A total of 100 documents were reviewed from a total of 48,998 publications. The citation counts of these articles ranged from 541 to 6482. These articles were published in 57 journals among which Phytotherapy Research, Food Chemistry and Journal of Agricultural and Food Chemistry were the most productive journals in terms of number of publications. In the case of contribution of countries and institutions, the USA (n = 12), and Agriculture University of Athens (n = 5) ranked first. The statistical analysis revealed a moderate positive correlation (R² = 0.5137) between the publication year and number. This analysis revealed critical themes, including the biological potential of EOs and their wide-ranging applications in aromatherapy, edible coatings, and food preservation – areas that were consistently highlighted in the leading cited studies. Overall, this study delineates the developments, research dynamics, and emerging trends in EO research, providing a significant reference for future studies.

在全球范围内，精油（EOs）因其适应性和消费者日益增长的兴趣而成为人们关注的焦点。引文确实代表了在某一特定领域所作的最重要的贡献。考虑到这一点，我们进行了文献计量分析，描述了100篇被引用最多的关于植物源性EOs的文章。相关信息是从Scopus数据库中检索出来的，并进行了手动审查。然后通过Microsoft Excel、Bibliometrix和VOSviewer软件对所选数据进行分析和可视化。共审查了48 998份出版物中的100份文件。这些文章的引用数从541到6482不等。这些文章发表在57种期刊上，其中以《植物疗法研究》、《食品化学》和《农业与食品化学杂志》发表数量最多。在国家和机构的贡献方面，美国（n = 12）和雅典农业大学（n = 5）排名第一。统计分析显示出版年份与出版数量之间存在中度正相关（R2 = 0.5137）。这一分析揭示了关键的主题，包括EOs的生物学潜力及其在芳香疗法、食用涂层和食品保鲜方面的广泛应用——这些领域在主要被引用的研究中一直得到强调。总体而言，本研究描述了生态环境研究的发展、研究动态和新兴趋势，为未来的研究提供了重要的参考。

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引用次数: 0

Role of biochanin A in the treatment of diabetes and its complications 生物茶素A在糖尿病及其并发症治疗中的作用

Pharmacological Research - Natural Products

Pub Date : 2026-01-03 DOI: 10.1016/j.prenap.2026.100491

Aminu Mohammed , Nasir Tajuddeen , Murtala Bindawa Isah , Mohammed Auwal Ibrahim

Biochanin A is a dietary isoflavone with several pharmacological effects, like anticancer, antimicrobial, and antidiabetic properties. Herein, the antidiabetic activities of biochanin A using various diabetes models, including cell line-based, in vivo, and in vitro assays, were reviewed. Relevant articles were sourced from the major scientific databases (Scopus, PubMed, and Google Scholar). The studies included were those that reported the effects of biochanin A on key diabetes markers, such as glucose utilisation and insulin sensitivity, in vitro and in vivo models, as well as in cell-based studies. Collectively, the data revealed that biochanin A has a potential to reduce hyperglycemia, insulin resistance, and diabetes-induced oxidative stress. Such activities were linked, among others, to the activation of Nrf2 and PI3K/Akt pathways, increasing adiponectin level and visfatin expressions as well as inhibitions of NF-κB, GSK3β and serum resistin. With the current available studies, biochanin A showed promising antidiabetic activity in several diabetes models with relatively no adverse side effects, although no study is available to confirm the efficacy in human volunteers. Detailed clinical trials and toxicological studies are warranted to validate the preclinical data.

生物茶素A是一种膳食异黄酮，具有多种药理作用，如抗癌、抗菌和抗糖尿病特性。本文综述了生物茶素A在各种糖尿病模型中的抗糖尿病活性，包括基于细胞系的、体内的和体外的实验。相关文章来源于主要的科学数据库（Scopus、PubMed和b谷歌Scholar）。这些研究包括那些在体外和体内模型以及基于细胞的研究中报道了生物茶素A对糖尿病关键标志物的影响，如葡萄糖利用和胰岛素敏感性。总的来说，数据显示生物茶素A具有降低高血糖、胰岛素抵抗和糖尿病诱导的氧化应激的潜力。这些活性与Nrf2和PI3K/Akt通路的激活、脂联素水平和visfatin表达的增加以及NF-κB、GSK3β和血清抵抗素的抑制有关。根据目前的研究，生物茶素A在几种糖尿病模型中显示出有希望的抗糖尿病活性，并且相对没有不良副作用，尽管没有研究证实其在人类志愿者中的功效。需要详细的临床试验和毒理学研究来验证临床前数据。

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引用次数: 0

Murraya koenigii as a phytotherapeutic agent in breast cancer: A comprehensive review Murraya koenigii作为一种植物治疗乳腺癌的药物：综述

Pharmacological Research - Natural Products

Pub Date : 2025-12-30 DOI: 10.1016/j.prenap.2025.100487

Debalina Bose , Sachin Shetty , Anushree Udupi , Kishore Srinivasan

Murraya koenigii (MK), a medicinal plant long esteemed in traditional Asian medicine, is rich in pharmacologically active constituents, particularly carbazole alkaloids (e.g., mahanine, koenimbine, girinimbine), flavonoids (e.g., myricetin, quercetin), and terpenoids. These compounds exert potent anticancer effects, especially against breast cancer, by inducing apoptosis, inhibiting metastasis, and modulating oxidative stress and inflammation. Mahanine has been shown to downregulate CDK4/6 and estrogen receptor-α, while koenimbine activates cytochrome c-mediated intrinsic apoptosis via caspase-9. MK extracts inhibit multiple oncogenic signaling cascades including NF-κB, PI3K/Akt/mTOR, and MAPK, and suppress proteasomal function and ROS-mediated proliferation. In vitro studies report IC₅₀ values as low as 4.5 µM (mahanimbine) and 6.5 µg/mL (silver nanoparticle-formulated MK extract) against MDA-MB-231 breast cancer cells. In vivo, MK administered at 300 mg/kg significantly reduced tumor burden and elevated apoptotic markers in 7,12-dimethylbenz[a]anthracene (DMBA)-induced rodent models. This review highlights MK’s potential as a low-toxicity adjunctive therapy in breast cancer treatment. Future directions include subtype-specific clinical trials, nanocarrier-based delivery systems, and biomarker-driven therapeutic stratification to facilitate clinical translation.

龙葵（MK）是亚洲传统医学中一种备受推崇的药用植物，具有丰富的药理活性成分，特别是咔唑类生物碱（如马汗碱、龙葵碱、吉莉宁）、类黄酮（如杨梅素、槲皮素）和萜类化合物。这些化合物通过诱导细胞凋亡，抑制转移，调节氧化应激和炎症，具有有效的抗癌作用，特别是对乳腺癌。Mahanine下调CDK4/6和雌激素受体-α，而koenimine通过caspase-9激活细胞色素c介导的内在凋亡。MK提取物抑制NF-κB、PI3K/Akt/mTOR和MAPK等多种致癌信号级联，抑制蛋白酶体功能和ros介导的增殖。体外研究报告IC₅0值低至4.5 µM （mahanimbine）和6.5 µg/mL（银纳米颗粒配制的MK提取物），可对抗MDA-MB-231乳腺癌细胞。在体内，给药剂量为300 mg/kg的MK可显著降低7,12-二甲基苯[a]蒽（DMBA）诱导的啮齿动物模型的肿瘤负荷，并升高凋亡标志物。这篇综述强调了MK在乳腺癌治疗中作为一种低毒性辅助疗法的潜力。未来的方向包括亚型特异性临床试验，基于纳米载体的递送系统，以及生物标志物驱动的治疗分层，以促进临床转化。

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引用次数: 0

Phytochemical and pharmacological potential of mangroves: A comprehensive review on traditional uses and medicinal prospects 红树林的植物化学和药理潜力：传统用途和药用前景的综合综述

Pharmacological Research - Natural Products

Pub Date : 2025-12-29 DOI: 10.1016/j.prenap.2025.100485

Shital S. Chavan , Prashant B. Shamkuwar , Manoj G. Damale

Background

Mangroves are ecologically significant plants that serve as valuable reservoirs of secondary metabolites with diverse pharmacological applications. Despite their extensive traditional use, limited scientific validation exists for many mangrove species and their bioactive compounds.

Objective

The goal of this review is to give a thorough overview of the taxonomy, ethno pharmacology, phytochemical profiles, and pharmacological activity of traditionally used mangroves. It does this by showing how useful they could be as medicine and how much more research has to be done.

Methods

A systematic literature review was conducted using databases such as Pub hem, Elsevier, Science Direct, Bentham Science, and other search engines. Relevant studies on the phytochemical constituents, pharmacological activities, and medicinal applications of mangrove species were analysed and synthesized.

Results

Mangrove makes a number of substances that are useful for medicine, including as flavonoids, saponins, tannins, alkaloids, phenolic compounds, terpenoids, and steroids. The predominant pharmacological activities reported include antioxidant, antimicrobial, antidiabetic, and antiulcer properties. While several species have demonstrated promising bioactivity, their potential for drug development remains underexplored. Notably, mangrove-derived compounds with antibacterial properties lack extensive formulation-based research, limiting their pharmaceutical applications.

Conclusion

There is a great need for thorough research supported by precise clinical and scientific data to guarantee the safety and effective use of these plants, to explore their full medicinal potential and facilitate drug discovery and validate their pharmacological characteristics and toxicity especially since mangroves have high potential for medicinal products and drug discovery to prevent and treat many diseases.

红树林是具有重要生态意义的植物，是具有多种药理应用的次生代谢物的宝贵储存库。尽管它们的传统用途广泛，但对许多红树林物种及其生物活性化合物的科学验证有限。目的对传统红树的分类、民族药理学、植物化学特征和药理活性进行综述。它通过展示它们作为药物是多么有用，以及需要做多少研究来做到这一点。方法利用Pub hem、Elsevier、Science Direct、Bentham Science等数据库及搜索引擎进行系统文献综述。对红树林植物化学成分、药理活性和药用价值的相关研究进行了分析和综合。结果红树可制取多种药用物质，包括黄酮类化合物、皂苷、单宁、生物碱、酚类化合物、萜类化合物和类固醇。主要的药理活性报道包括抗氧化，抗菌，抗糖尿病和抗溃疡的性质。虽然一些物种已经显示出有希望的生物活性，但它们的药物开发潜力仍未得到充分开发。值得注意的是，具有抗菌特性的红树林衍生化合物缺乏广泛的基于配方的研究，限制了它们的制药应用。结论红树林在预防和治疗多种疾病方面具有巨大的药用潜力和药物开发潜力，因此需要在精确的临床和科学数据支持下进行深入的研究，以保证其安全有效的利用，充分挖掘其药用潜力，促进药物开发，验证其药理特性和毒性。

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引用次数: 0

A review on the phytochemicals of Eclipta prostrata and Eclipta alba: Antioxidants and antidiabetic activities 黄花和白花黄花植物化学成分的研究进展：抗氧化和抗糖尿病活性

Pharmacological Research - Natural Products

Pub Date : 2025-12-29 DOI: 10.1016/j.prenap.2025.100483

Nur Nahar Sohe , John Sushma Nannepaga , Wan Amir Nizam Wan Ahmad , Norizah Mhd. Sarbon , Mannur Ismail Shaik

Diabetes mellitus, also known as Diabetes, poses a threat to human health by affecting millions worldwide and ranking among the leading causes of mortality and disability. The urgent need for safer, cost-effective natural alternatives to synthetic drugs has sparked a profound interest in medicinal plants with dual antioxidant and antidiabetic properties. Eclipta species, particularly Eclipta prostrata and Eclipta alba, are traditionally recognized in Ayurveda, Traditional Chinese Medicine and folk healing systems for their rich phytochemical composition and diverse pharmacological properties. The whole plant, including leaves, stems and roots, has been shown to contain a variety of secondary metabolites such as flavonoids, phenols, terpenoids, alkaloids, coumarins, polyacetylenes, tannins and others that contribute to various therapeutic activities. These species exhibit potent antioxidant activities through free radical scavenging, thereby reducing oxidative stress. Their antidiabetic effects are primarily linked to the inhibition of carbohydrate-hydrolyzing enzymes (α-amylase and α-glucosidase), modulation of glucose metabolism, and resistance to oxidative damage. Although they exhibit promising medicinal activities in both traditional and modern medicine, comparative studies between species, standardized phytochemical profiling are limited. Therefore, this review, for the first time, summarizes the major phytochemical profiles (mostly flavonoids and phenolic compounds) of E. prostrata and E. alba, particularly the correlations between phytochemical classes and their contributions to antioxidant and antidiabetic activities. The findings highlight the possibilities of E. prostrata and E. alba for developing standardized nutraceuticals and plant-based formulations to mitigate oxidative stress and manage diabetes.

糖尿病，又称糖尿病，对人类健康构成威胁，影响到全世界数百万人，是导致死亡和残疾的主要原因之一。迫切需要更安全、成本效益高的天然替代品来替代合成药物，这引发了人们对具有双重抗氧化和抗糖尿病特性的药用植物的浓厚兴趣。黄赤藓属植物，特别是黄赤藓和白黄赤藓，因其丰富的植物化学成分和多样的药理特性，在传统的阿育吠陀、传统中医和民间治疗系统中得到认可。整个植物，包括叶、茎和根，已被证明含有各种次生代谢物，如黄酮类、酚类、萜类、生物碱、香豆素、聚乙炔、单宁和其他有助于各种治疗活性的物质。这些物种通过清除自由基表现出强大的抗氧化活性，从而减少氧化应激。其抗糖尿病作用主要与抑制碳水化合物水解酶（α-淀粉酶和α-葡萄糖苷酶）、调节葡萄糖代谢和抵抗氧化损伤有关。尽管它们在传统和现代医学中都显示出很有前景的药用活性，但物种之间的比较研究和标准化的植物化学谱分析有限。因此，本文首次对其主要的植物化学特征（主要是黄酮类和酚类化合物）进行了综述，重点介绍了植物化学分类与抗氧化和抗糖尿病活性之间的关系。研究结果强调了proprostrata和E. alba在开发标准化营养药品和植物配方以减轻氧化应激和控制糖尿病方面的可能性。

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引用次数: 0

The effects of anthocyanin consumption on functional connectivity in dementia and type 2 diabetes mellitus 花青素摄入对痴呆和2型糖尿病患者功能连接的影响

Pharmacological Research - Natural Products

Pub Date : 2025-12-29 DOI: 10.1016/j.prenap.2025.100486

Aynur Muduroglu Kirmizibekmez , Alparslan Onder , Mustafa Yasir Ozdemir , Onder Yuksel Eryigit , İhsan Kara

This study investigates the effects of 12 weeks of anthocyanin consumption on brain function in individuals with Dementia with Type 2 Diabetes Mellitus (T2DM) and Dementia alone. Two groups of individuals: 12 participants with T2DM comorbid with dementia and 31 participants with dementia alone. EEG recordings were collected at baseline, before the start of the study, and after 12 weeks of anthocyanin consumption. During the study period, participants consumed 300 mg of anthocyanins daily. EEG recordings were conducted using a 21-channel gel EEG cap following the 10–20 system at a sampling rate of 500 Hz. EEG signals were divided into seven frequency bands, and the Imaginary Part of Coherence (iCOH) metric, which reduces volume conduction effects, was used to evaluate functional connectivity. Within-group analyses were performed using the Wilcoxon signed-rank test, and between-group comparisons were conducted using the Mann-Whitney U test, both implemented in Python. This study demonstrates that 12 weeks of anthocyanin supplementation positively impacts neural network efficiency and functional connectivity in both the Cognitive Impairment (CI) group and the Type 2 Diabetes Mellitus with Cognitive Impairments (T2DMwCI) group. Significant improvements were observed in iCOH, GE, and LE metrics across delta, theta, beta, and gamma frequency bands, indicating enhanced information processing and potential compensatory mechanisms. These findings highlight the neuroprotective properties of anthocyanins, suggesting their potential to mitigate cognitive decline associated with T2DM and dementia. As a result, it supports the idea that anthocyanins are a potential dietary intervention for mitigating cognitive decline, though further research is needed to validate and expand these results.

本研究探讨了12周花青素摄入对痴呆合并2型糖尿病（T2DM）和单纯痴呆患者脑功能的影响。两组个体：12名T2DM合并痴呆的参与者和31名单独痴呆的参与者。在基线、研究开始前和服用花青素12周后收集脑电图记录。在研究期间，参与者每天摄入300 毫克的花青素。EEG记录使用21通道凝胶EEG帽，遵循10-20系统，采样率为500 Hz。将脑电信号划分为7个频带，采用减少体积传导效应的虚部相干度（iCOH）指标评价功能连通性。组内分析使用Wilcoxon符号秩检验，组间比较使用Mann-Whitney U检验，两者都是用Python实现的。本研究表明，12周的花青素补充对认知障碍（CI）组和2型糖尿病合并认知障碍（T2DMwCI）组的神经网络效率和功能连接都有积极的影响。在δ、θ、β和γ频段上观察到iCOH、GE和LE指标的显著改善，表明信息处理和潜在的补偿机制得到增强。这些发现强调了花青素的神经保护特性，表明它们有可能减轻与2型糖尿病和痴呆相关的认知能力下降。因此，它支持了花青素是一种潜在的饮食干预来减轻认知能力下降的观点，尽管需要进一步的研究来验证和扩展这些结果。

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引用次数: 0

Nanotechnology in phytochemical-based cancer therapy: A comprehensive review of plant-derived nano formulations 纳米技术在植物化学癌症治疗中的应用：植物源纳米制剂的综合综述

Pharmacological Research - Natural Products

Pub Date : 2025-12-28 DOI: 10.1016/j.prenap.2025.100484

Sreejan Manna , Pabitra Maity , Poulami Sarkar , Olivia Sen , Sougata Jana , Gouranga Nandi , Ranabir Sahu , Priya Das

Cancer continues to exert a profound impact on global health, with a steadily increasing number of cases and deaths reported each year. Despite notable progress in diagnosis and treatment, many patients still face significant challenges due to the toxicity, limited selectivity, and high cost of conventional cancer therapies. These limitations often compromise treatment outcomes and quality of life, particularly in vulnerable populations, emphasizing the need for safer and more effective therapeutic approaches. Medicinal plants have long served as a rich source of bioactive compounds with demonstrated anticancer potential. Phytochemicals such as polyphenols, alkaloids, and terpenoids exhibit diverse biological activities, including antioxidant, anti-inflammatory, and apoptosis-inducing effects, making them attractive candidates for cancer management. However, their broader clinical application remains constrained by issues such as poor solubility, low stability, rapid metabolism, and inadequate bioavailability. Recent advances in nanotechnology offer promising solutions to these challenges by enabling improved protection, controlled release, and targeted delivery of plant-derived bioactives. In particular, green synthesis of nanoparticles integrates principles of sustainability with therapeutic innovation, enhancing both efficacy and biocompatibility. This review discusses current developments in plant-based anticancer nano formulations, highlights their therapeutic relevance against major cancer types, and outlines key scientific and regulatory challenges that must be addressed to facilitate successful clinical translation.

癌症继续对全球健康产生深远影响，每年报告的病例和死亡人数稳步增加。尽管在诊断和治疗方面取得了显著进展，但由于传统癌症治疗的毒性、有限的选择性和高成本，许多患者仍然面临着重大挑战。这些限制往往会影响治疗结果和生活质量，特别是在弱势人群中，因此需要更安全、更有效的治疗方法。药用植物长期以来一直是具有抗癌潜力的生物活性化合物的丰富来源。植物化学物质如多酚、生物碱和萜类化合物表现出多种生物活性，包括抗氧化、抗炎和诱导细胞凋亡的作用，使它们成为癌症治疗的有吸引力的候选者。然而，其广泛的临床应用仍然受到诸如溶解度差、稳定性低、代谢快和生物利用度不足等问题的限制。纳米技术的最新进展通过改善植物源性生物活性的保护、控制释放和靶向递送，为这些挑战提供了有希望的解决方案。特别是，纳米颗粒的绿色合成将可持续性原则与治疗创新相结合，提高了疗效和生物相容性。这篇综述讨论了目前植物基抗癌纳米制剂的发展，强调了它们对主要癌症类型的治疗相关性，并概述了为促进成功的临床转化必须解决的关键科学和监管挑战。

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引用次数: 0

Multi-target anti diabetic potential of Syzygium cumini phytochemicals: An in silico analysis 茴香植物化学物质多靶点抗糖尿病潜能的计算机分析

Pharmacological Research - Natural Products

Pub Date : 2025-12-27 DOI: 10.1016/j.prenap.2025.100482

M. Kavino , B. Rajagopal , Prasanna. Seenivasan , Abdul. Latheef , S. Rajesh

Diabetes mellitus, a multifactorial disease characterized by chronic hyperglycemia, remains a global health challenge despite existing pharmacotherapies. The complex pathophysiology of diabetes, involving dysregulation in glucose metabolism, insulin signaling, and inflammation, necessitates multi-target therapeutic strategies. Phytochemicals derived from Syzygium cumini have demonstrated significant potential as natural, multi-target antidiabetic agents. This study aims to investigate the bioactive compounds from S. cumini using computational approaches, including molecular docking, ADMET profiling, and network pharmacology. A library of 48 phytochemicals was screened for drug-likeness and cardiotoxicity, with maslinic acid, quercetin, and ellagic acid emerging as key candidates due to favorable pharmacokinetic profiles. Molecular docking revealed strong interactions with critical diabetic targets with maslinic acid showing the highest binding affinity for Dipeptidyl Peptidase-4 (DPP4) (-9.6 kcal/mol). Network pharmacology analysis further demonstrated the multi-target potential of these compounds, highlighting their role in modulating key metabolic pathways related to insulin sensitivity and glucose homeostasis. The results suggest that S. cumini phytochemicals, particularly maslinic acid, quercetin, and ellagic acid, offer promising therapeutic potential for diabetes management through a multi-target approach. This integrative computational approach can help us to find a potential anti-diabetic compound. Future in-vitro and in-vivo studies are warranted to validate these findings and explore synergistic interactions among the compounds for enhanced therapeutic efficacy.

糖尿病是一种以慢性高血糖为特征的多因素疾病，尽管已有药物治疗，但仍是全球健康挑战。糖尿病复杂的病理生理，包括糖代谢、胰岛素信号和炎症的失调，需要多靶点的治疗策略。从茴香中提取的植物化学物质作为天然的、多靶点的抗糖尿病药物已经显示出巨大的潜力。本研究旨在利用分子对接、ADMET谱分析和网络药理学等计算方法研究牛蒡子的生物活性成分。筛选了48种植物化学物质的药物相似性和心脏毒性，由于良好的药代动力学特征，山茱萸酸、槲皮素和鞣花酸成为关键候选物质。分子对接发现，山楂酸与糖尿病关键靶点有很强的相互作用，对二肽基肽酶-4 （DPP4）具有最高的结合亲和力（-9.6 kcal/mol）。网络药理学分析进一步证明了这些化合物的多靶点潜力，突出了它们在调节与胰岛素敏感性和葡萄糖稳态相关的关键代谢途径中的作用。结果表明，山茱萸植物化学物质，特别是山茱萸酸、槲皮素和鞣花酸，通过多靶点的方法为糖尿病治疗提供了有希望的治疗潜力。这种综合计算方法可以帮助我们找到一种潜在的抗糖尿病化合物。未来的体外和体内研究有必要验证这些发现，并探索化合物之间的协同相互作用，以提高治疗效果。

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引用次数: 0