Pharmacological Research - Natural Products最新文献

{"title":"Ethnopharmacological relevance, phytochemistry, potential health benefits and toxicity profile of Ananas comosus (L.) Merr (pineapple)","authors":"Eziuche A. Ugbogu ,&nbsp;Emeka Joshua Iweala ,&nbsp;Chukwudi Eke Ukachukwu ,&nbsp;Christy Babayo ,&nbsp;Omoremime Elizabeth Dania ,&nbsp;Chollom Longs Isreal ,&nbsp;Conrad A. Omonhinmin ,&nbsp;Wisdom Dehorah Cleanclay ,&nbsp;Benedict Chukwuebuka Okoro","doi":"10.1016/j.prenap.2026.100550","DOIUrl":"10.1016/j.prenap.2026.100550","url":null,"abstract":"<div><div>In traditional medicine, the cortexes of <em>A. comosus</em> are used as an alexipharmic, antitussive, and antidiarrheal agent, while the leaves are commonly used as a remedy for indigestion. This review provides a thorough and up-to-date literature on the ethnopharmacological uses, phytochemistry, and potential health benefits of <em>A. comosus</em>. The articles used for this study were obtained from databases such as ScienceDirect, Frontiersin, PubMed, Springer, and MDPI. In addition, only articles written in English were included in this review. Phytochemical analysis revealed that <em>A. comosus</em> contains numerous biologically active compounds, including n-hexadecanoic acid, bromelain, n-heptadecanol-1, methyl ester, hexadecanoic acid, squalene, α-tocopherol, tetradecane, 5-hydroxymethylfurfural, dihydroxyacetone, dodecane, DL-α-tocopherol, furan methanol, dodecanoic acid, and 2,4,6-cycloheptatrien-1-one, among others. Various <em>in vivo</em> and <em>in vitro</em> biochemical studies have also shown that <em>A. comosus</em> possesses antioxidant, anti-inflammatory, anticancer, antidiarrheal, antimicrobial, antimalarial, cardioprotective, anthelmintic, and antidiabetic properties. Therefore, this review shows the biologically active compounds in <em>A. comosus</em> and the potential of different parts of <em>A. comosus</em> to prevent and treat various diseases. While <em>A. comosus</em> has shown promise in animal studies, human clinical trials are needed to determine safe and effective doses. Further research may reveal additional uses for this versatile plant as a functional food and in modern healthcare as a traditional and complementary alternative medicine.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"10 ","pages":"Article 100550"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146173588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Co-administration of phytochemicals and anti-melanoma drugs: Mechanisms, metastasis prevention, and regulatory challenges","authors":"Irem Beyza Huner,&nbsp;Muge Kasim Kirac,&nbsp;Kutlu O. Ulgen","doi":"10.1016/j.prenap.2025.100465","DOIUrl":"10.1016/j.prenap.2025.100465","url":null,"abstract":"<div><div>This review focuses on the pharmacokinetic effects of phytochemicals or foods on drugs currently used for melanoma therapy or those with the potential to prevent melanoma metastasis. The pharmacokinetic effects of piperine, <em>Eurycoma longifolia</em>, and garlic co-administered with propranolol, as well as carvone and orange juice co-administered with ivermectin, are investigated, along with the impact of imperatorin on dabrafenib pharmacokinetic parameters. Upon research suggesting that platelet inhibition may be useful for preventing melanoma metastases, the pharmacokinetic parameters of ticagrelor are examined in the context of grapefruit juice consumption or the administration of conventional anticancer drugs. Across the reviewed studies, piperine and garlic increased propranolol bioavailability up to twofold, while imperatorin elevated dabrafenib plasma exposure by more than threefold through CYP3A4 inhibition. Conversely, Eurycoma longifolia and orange juice decreased drug absorption, illustrating the dual modulatory potential of dietary agents on melanoma therapies. The possible drawbacks and advantages of these synergistic phytochemical-drug combinations are discussed, along with regulatory and ethical challenges. The mechanistic and molecular aspects of reshaping therapeutic dynamics upon coadministration of drugs and phytochemicals are deliberated. Precision medicine and phytochemical delivery technologies are highlighted.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"10 ","pages":"Article 100465"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145791779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Centella asiatica: An ethnobotanical treasure with promising anticancer properties","authors":"Sanjukta Sen ,&nbsp;Siuli Sen ,&nbsp;Dipanjan Karati","doi":"10.1016/j.prenap.2026.100490","DOIUrl":"10.1016/j.prenap.2026.100490","url":null,"abstract":"<div><div><em>Centella asiatica</em> (L.) Urb., commonly known as Gotu Kola, is a green leafy vegetable and traditional medicinal plant widely distributed in Southeast Asia. Renowned for its diverse therapeutic applications, it is a rich source of bioactive molecules, including triterpenoids, carotenoids, flavonoids, polyphenols, tannins, and volatile oils. These compounds are linked to its anti-inflammatory, antibacterial, antioxidant, wound-healing, neuroprotective, and antidiabetic properties. Recent research has highlighted its anticancer potential, attributed to bioactive constituents such as asiaticoside and madecassoside, which demonstrate antitumor activities through the modulation of oxidative stress, apoptosis, inflammation, and mitochondrial dysfunction. The plant's antioxidant and antiangiogenic properties play a vital role in inhibiting tumor growth and metastasis, while its ability to synergize with chemotherapeutic agents offers promise for enhancing cancer treatment efficacy. However, factors such as processing methods and environmental conditions significantly influence its phytochemical composition and therapeutic efficacy. Despite compelling preclinical evidence, clinical trials evaluating its anticancer potential are limited. Further research is essential to elucidate its molecular mechanisms of action, standardize processing techniques, and establish comprehensive safety profiles. Advancing these efforts will enable the transition of <em>Centella asiatica</em> from traditional medicine to a scientifically validated anticancer therapeutic, bridging the gap between ethnopharmacology and modern oncology.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"10 ","pages":"Article 100490"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145926603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unlocking the phytochemical contents and therapeutic potential of Litsea monopetala leaves: Hypoglycemic and antibacterial activities","authors":"Zubair Khalid Labu ,&nbsp;Samira Karim ,&nbsp;Rahima Akter ,&nbsp;Sarder Arifuzzaman ,&nbsp;Md. Hasibul Hassan ,&nbsp;Md. Nahid Hasan ,&nbsp;Atiqur Rahman ,&nbsp;Md. Tarekur Rahman ,&nbsp;Md. Ataur Rahman ,&nbsp;Asma Akhtar","doi":"10.1016/j.prenap.2026.100527","DOIUrl":"10.1016/j.prenap.2026.100527","url":null,"abstract":"<div><div><em>Litsea monopetala</em> (LM), and bark are applied externally to treat swelling, bruises, skin infections, and inflammatory conditions. Occasionally, leave decoctions are used as topical washes or mild teas for digestive ailments and fever; however, internal use remains limited and guided by local knowledge. This study aimed to scientifically validate these traditional uses by assessing the hypoglycemic and antibacterial properties of LM leaves. Methanolic extracts were prepared via cold extraction and analyzed through standard phytochemical techniques and High-Performance Liquid Chromatography, revealing a high concentration of phenolic and flavonoid compounds. Oral Glucose Tolerance Tests in mice showed that both 250 mg/kg and 500 mg/kg doses significantly reduced blood glucose levels, with the higher dose yielding effects comparable to glibenclamide. In alloxan-induced diabetic mice, blood glucose levels dropped from 240.90 ± 6.16–145.17 ± 4.19 mg/dL by day 7 (p &lt; 0.01). In normal mice, the 500 mg/kg dose also caused a significant reduction (p &lt; 0.01). Antibacterial activity, evaluated using the disc diffusion method, revealed inhibition zones of 10–21 mm at a 400-μg dose, with carbon tetrachloride soluble fraction, chloroform soluble fraction, and ethyl acetate soluble fraction fractions demonstrating significantly stronger effects (p &lt; 0.05). These findings support the traditional use of LM and suggest potential for its development into hypoglycemic and antimicrobial agents. The results support the traditional use of LM leaves, highlighting strong hypoglycemic and antibacterial potential. These effects are likely linked to rich phenolic and flavonoid content, indicating promise for future therapeutic applications.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"10 ","pages":"Article 100527"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146026101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemicals from corn plant as anti-inflammatory agents: Molecular insights and therapeutic perspectives","authors":"S. Rajeshwari ,&nbsp;Abu Safana Biswas ,&nbsp;J. Suresh ,&nbsp;Erica Alves ,&nbsp;B.M. Gurupadayya ,&nbsp;Archana Pilli ,&nbsp;SubbaRao V. Madhunapantula ,&nbsp;P. Pattaluchetty","doi":"10.1016/j.prenap.2026.100497","DOIUrl":"10.1016/j.prenap.2026.100497","url":null,"abstract":"<div><div>The pathophysiology of many chronic diseases, such as metabolic syndrome, neurodegeneration, and cardiovascular ailments, is based on inflammation. Plant-derived bioactives are being investigated more and more in this regard as safer substitutes for traditional anti-inflammatory medications. Beyond its nutritional value, <em>Zea mays</em> (corn) has a wide range of phytochemicals with proven anti-inflammatory properties, including flavonoids, anthocyanins, phenolic acids, and carotenoids. With a focus on their molecular processes, targeted inflammatory pathways (NF-κB, MAPK, COX-2, iNOS), and regulatory effects on cytokines (TNF-α, IL-6, IL-1β), this review summarizes the most recent preclinical and limited clinical results on the anti-inflammatory efficacy of substances produced from corn plant. It has been demonstrated that extracts from various sections, including as the husk, pericarp, kernel, cob, and silk, decrease oxidative stress, alter immunological signaling, and maintain tissue integrity. The clinical promise of Maizinol®, a standardized corn leaf extract registered under ISRCTN13394796, as a natural sleep aid is further demonstrated by its translational research path, which also emphasizes the corn plant's wider medicinal potential. There are still issues with phytochemical bioavailability, standardization, and translational clinical evidence despite encouraging bioactivity. All things considered, the corn plant is a sustainable botanical resource with significant therapeutic and nutraceutical promise in inflammatory illnesses. To fully realize its pharmacological potential, more mechanistic and clinical research is necessary.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"10 ","pages":"Article 100497"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146026170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroprotective effect of abietic acid against sodium valproate induced autism in male and female rat pups","authors":"Prity Lather,&nbsp;Dinesh Dhingra","doi":"10.1016/j.prenap.2026.100536","DOIUrl":"10.1016/j.prenap.2026.100536","url":null,"abstract":"<div><div>Autism spectrum disorder (ASD) is a neurodevelopmental disorder. Two FDA approved drugs such as risperidone and aripiprazole have been reported to treat some symptoms of ASD in children and adolescents. But both these drugs have side effects. Therefore, it is worthwhile to explore safer alternatives such as medicinal plants and bioactive compounds for management of autism. Abietic acid, a resin present in various species of <em>Pinus</em>. It exhibits anti-depressant, memory improving, anti-inflammatory and antioxidant activities, suggesting its potential to ameliorate autism–like symptoms. The current study investigated the effect of abietic acid on sodium valproate- induced autism in male and female rat pups to assess sex- specific responses. For inducing autism, 400 mg/kg of sodium valproate was injected subcutaneously to pregnant female rats on 12th day of gestation. Abietic acid (7.5, 15, 30 mg/kg, p.o.) and standard drugs (diazepam, fluoxetine, and donepezil, i.p.) were given to separate groups of autistic pups from 26th to 40th postnatal days. Behavioural assessments revealed that autistic pups were depressed; showed repetitive and anxious behaviours; showed impairment of learning and memory; and impairment of social interaction; and increased locomotion. Biochemical analysis showed increased brain oxidative stress parameters, acetylcholinesterase activity, neuro-inflammation and apoptosis along with decreased mitochondrial complexes activities. Abietic acid (15, 30 mg/kg) remarkably reversed these behavioural deficits and restored biochemical parameters towards normal in both male and female autistic pups. These findings indicated that abietic acid produced significant neuro-protective effects in autistic pups, possibly through inhibition of acetylcholinesterase activity, amelioration of neuro-inflammation, oxidative stress, mitochondrial dysfunction, and apoptosis. Overall, this study highlights the potential of abietic acid as a natural intervention for management of autism-like behaviours.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"10 ","pages":"Article 100536"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146077784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacologicalacological evaluation of methanolic leaf extract of Streblus asper: Experimental and in silico approaches to analgesic, diuretic, thrombolytic, and anti-arthritic potentials","authors":"Md. Hossain Rasel ,&nbsp;Md. Abdul Alim ,&nbsp;Md. Jahirul Islam Mamun ,&nbsp;Salma Sultana Sumi ,&nbsp;Md. Tanvir Chowdhury ,&nbsp;S. M. Naim Uddin","doi":"10.1016/j.prenap.2026.100546","DOIUrl":"10.1016/j.prenap.2026.100546","url":null,"abstract":"<div><div><em>Streblus asper</em> (Family: Moraceae) has been traditionally used for various ailments, yet its pharmacological basis remains poorly established. This study evaluated the analgesic, diuretic, thrombolytic, and antiarthritic activities of the methanolic leaf extract of <em>S. asper</em> (SAL-ME), supported by in silico validation. Analgesic activity was investigated using acetic acid-induced writhing and formalin-induced paw licking tests in mice. Diuretic activity was assessed by urinary electrolyte excretion and urine volume. Thrombolytic and antiarthritic effects were determined using in vitro clot lysis and protein denaturation assays. ADME, toxicity, PASS prediction, and molecular docking analyses were employed to explore pharmacokinetic properties and binding interactions. SAL-ME significantly reduced writhing responses (50.18 % inhibition at 400 mg/kg; <em>p</em> &lt; 0.001) and suppressed pain in both the early (22.93 % inhibition; <em>p</em> &lt; 0.05) and late inflammatory phases (85.35 % inhibition; <em>p</em> &lt; 0.001) of the formalin test. Diuretic activity was evidenced by elevated urinary sodium, potassium, and chloride excretion (<em>p</em> &lt; 0.01 to <em>p</em> &lt; 0.001) and increased urine output, with a diuretic index of 4.03 at 400 mg/kg, close to furosemide (4.83). The extract exhibited significant thrombolytic activity (69.04 % clot lysis; <em>p</em> &lt; 0.001) and antiarthritic potential (IC₅₀ = 62.93 µg/mL). In silico results showed octadecanoic acid as the strongest binder of COX-2 (–6.7 kcal/mol) and carbonic anhydrase II (–6.0 kcal/mol), supporting its analgesic and diuretic roles. Myo-inositol exhibited the highest affinity for tPA (–6.2 kcal/mol), indicating thrombolytic potential, while hexadecanoic acid showed the best binding to TNF-α (–5.3 kcal/mol), suggesting antiarthritic activity. ADME and toxicity predictions suggested favourable pharmacokinetics and safety. The methanolic leaf extract of <em>S. asper</em> demonstrates significant (<em>p</em> &lt; 0.05 to <em>p</em> &lt; 0.001) analgesic, diuretic, thrombolytic, and antiarthritic activities, corroborated by in silico studies. These findings highlight its potential as a natural source of multifunctional therapeutic agents and warrant further phytochemical and clinical investigations.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"10 ","pages":"Article 100546"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146173590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Review on phytochemistry and pharmacology of Pterocarpus marsupium: A journey of traditional medicine","authors":"Aishwarya Susil ,&nbsp;Haritha Harindranath ,&nbsp;S. Rajeshwari ,&nbsp;Mahendran Sekar ,&nbsp;Antony Justin ,&nbsp;N. Vijaya Ganesh ,&nbsp;P.B. Manaswini ,&nbsp;B.R. Prashantha Kumar","doi":"10.1016/j.prenap.2026.100544","DOIUrl":"10.1016/j.prenap.2026.100544","url":null,"abstract":"<div><h3>Background</h3><div>Pterocarpus <em>marsupium</em> (PM), a well-known medicinal plant used extensively in the traditional medicine for managing diabetes and several other ailments from the past to the present.</div></div><div><h3>Objective</h3><div>This review provides a comprehensive overview of PM, its medicinal uses and the scientific reports supporting its therapeutic potentials.</div></div><div><h3>Methodology</h3><div>Electronic searches like Google Scholar, PubMed, ScienceDirect, SciFinder and published books were used to gather the literature for this review in accordance with PRISMA guidelines.</div></div><div><h3>Results</h3><div>We highlight its diverse bioactive compounds, including flavonoids, tannins, terpenoids, and newly identified constituents like Pterocarposide and Sabioside. Key biological effects including antidiabetic, anti-inflammatory, neuroprotective, cardioprotective, and anticancer properties, are discussed here with emphasis on their molecular mechanisms. Extraction methods such as solvent extraction, supercritical fluid extraction and column chromatography are critically examined for their efficiency in isolation of bioactive compounds. Despite the plant’s therapeutic promise, concerns regarding its safety and toxicity remain unexplored. Therefore, there is a need for comprehensive toxicological studies. Clinical trials evaluating PM based formulations and emerging research on PM nanoparticles are summarized as they demonstrate their potential to be a new drug.</div></div><div><h3>Conclusion</h3><div>The review projects future research directions on PM, the need for the exploration of novel phytochemicals, the development of advanced delivery systems and the validation of its therapeutic efficacy through detailed clinical and toxicological studies.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"10 ","pages":"Article 100544"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146173591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phenolic profiling and antioxidant activity assessment of selected extracts from the leaves of the Algerian endemic plant Anthemis secundiramea (Asteraceae)","authors":"Mellouk Karima ,&nbsp;Charef Azzeddine ,&nbsp;Chohra Djawhara ,&nbsp;Ferchichi Loubna","doi":"10.1016/j.prenap.2025.100480","DOIUrl":"10.1016/j.prenap.2025.100480","url":null,"abstract":"<div><div>Anthemis secundiramea is an endemic species of the Asteraceae family, native to northeastern Algeria. Despite its unique presence in this region, a comprehensive phytochemical study focusing on its phenolic content has not yet been conducted. In this work, we obtained four leaf extracts of this species using ultrasonic extraction with different solvents.To quantify the phenolic compounds present in the aerial parts (leaves) of Anthemis secundiramea, we conducted several analyses to determine their phenolic composition and antioxidant activity. Two qualitative and quantitative colorimetric methods, employing specific reagents, were used. The results confirmed that this plant is indeed rich in phenolic compounds. Antioxidant activities were evaluated using two different assays: the free radical scavenging test (DPPH) and the ferric reducing antioxidant power test (FRAP).Additionally, the phenolic profiles of the extracts were determined by high-performance liquid chromatography coupled with a diode-array detector (HPLC/DAD). Among the various extracts studied, the methanol/water extract exhibited the highest antioxidant capacity (IC50: 1.42 ± 0.01) and contained the highest levels of total phenols (109.159 ± 12.213 mg GAE/g) and total flavonoids (95.44 ± 3.93 mg QE/g). The HPLC/DAD analysis also revealed that the leaves of Anthemis secundiramea are particularly rich in catechin, cinnamic acid, and coumaric acid.This study highlights the antioxidant potential of Anthemis secundiramea, emphasizing its richness in bioactive compounds. Further exploration is needed to fully understand the role of these bioactive compounds in herbal drug development, potentially paving the way for new natural antioxidant sources.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"10 ","pages":"Article 100480"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145841149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review on the phytochemicals of Eclipta prostrata and Eclipta alba: Antioxidants and antidiabetic activities","authors":"Nur Nahar Sohe ,&nbsp;John Sushma Nannepaga ,&nbsp;Wan Amir Nizam Wan Ahmad ,&nbsp;Norizah Mhd. Sarbon ,&nbsp;Mannur Ismail Shaik","doi":"10.1016/j.prenap.2025.100483","DOIUrl":"10.1016/j.prenap.2025.100483","url":null,"abstract":"<div><div>Diabetes mellitus, also known as Diabetes, poses a threat to human health by affecting millions worldwide and ranking among the leading causes of mortality and disability. The urgent need for safer, cost-effective natural alternatives to synthetic drugs has sparked a profound interest in medicinal plants with dual antioxidant and antidiabetic properties. <em>Eclipta</em> species, particularly <em>Eclipta prostrata</em> and <em>Eclipta alba</em>, are traditionally recognized in Ayurveda, Traditional Chinese Medicine and folk healing systems for their rich phytochemical composition and diverse pharmacological properties. The whole plant, including leaves, stems and roots, has been shown to contain a variety of secondary metabolites such as flavonoids, phenols, terpenoids, alkaloids, coumarins, polyacetylenes, tannins and others that contribute to various therapeutic activities. These species exhibit potent antioxidant activities through free radical scavenging, thereby reducing oxidative stress. Their antidiabetic effects are primarily linked to the inhibition of carbohydrate-hydrolyzing enzymes (α-amylase and α-glucosidase), modulation of glucose metabolism, and resistance to oxidative damage. Although they exhibit promising medicinal activities in both traditional and modern medicine, comparative studies between species, standardized phytochemical profiling are limited. Therefore, this review, for the first time, summarizes the major phytochemical profiles (mostly flavonoids and phenolic compounds) of <em>E. prostrata</em> and <em>E. alba</em>, particularly the correlations between phytochemical classes and their contributions to antioxidant and antidiabetic activities. The findings highlight the possibilities of <em>E. prostrata</em> and <em>E. alba</em> for developing standardized nutraceuticals and plant-based formulations to mitigate oxidative stress and manage diabetes.</div></div>","PeriodicalId":101014,"journal":{"name":"Pharmacological Research - Natural Products","volume":"10 ","pages":"Article 100483"},"PeriodicalIF":0.0,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145885058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}