Science in One Health最新文献

Fieldwork on animals living in extreme conditions as a source of biomedical innovation

Science in One Health

Pub Date : 2025-01-01 DOI: 10.1016/j.soh.2024.100096

Yvon Le Maho , Aurélie Tasiemski , Fabrice Bertile , Philippe Bulet

Most biomedical research on animals is based on the handful of the so-called standard model organisms, i.e. laboratory mice, rats or Drosophila, but the keys to some important biomedical questions may simply not be found in these. However, compared with the high number of molecules originating from plants in clinical use, and with the countless unique adaption mechanisms that animals have developed over the course of evolution to cope with environmental constrains, there is still few investigations on wild animals with biomedical objectives, and field studies are far fewer. A major limitation is insufficient funding, the main causes of which we analyze. We argue, however, that fieldwork is a key driver in generating new scientific knowledge as part of a One Health approach, by observing/documenting and understanding the diverse and largely unexplored biological processes evolved by animals adapted to unusual environmental conditions, which would be extreme conditions for humans. These conditions do not only refer to extreme temperatures, since lack of food or water, high pressures or lack of oxygen, are clearly extreme constraints. To conduct this research, there are serious limitations we propose to address. Specific techniques and methods are requested, not only to work in extreme environments, but also to minimize the ecological footprint of field work. The erosion of biodiversity is a major threat. The reduction of animal disturbance, a key issue, requires specific technologies and expertise. An ethical approach is requested, for the sake of transparency and to comply with the Nagoya Protocol on genetic resources. An interdisciplinary expertise and a meticulous planning are requested to overcome the field constraints and interface the associated laboratory work. We recommend focusing on the major threats to global human health today, which wild animals appear to resist particularly well, such as antibioresistance and diseases associated with lifestyle and senescence.

{"title":"Fieldwork on animals living in extreme conditions as a source of biomedical innovation","authors":"Yvon Le Maho , Aurélie Tasiemski , Fabrice Bertile , Philippe Bulet","doi":"10.1016/j.soh.2024.100096","DOIUrl":"10.1016/j.soh.2024.100096","url":null,"abstract":"<div><div>Most biomedical research on animals is based on the handful of the so-called standard model organisms, i.e. laboratory mice, rats or <em>Drosophila</em>, but the keys to some important biomedical questions may simply not be found in these. However, compared with the high number of molecules originating from plants in clinical use, and with the countless unique adaption mechanisms that animals have developed over the course of evolution to cope with environmental constrains, there is still few investigations on wild animals with biomedical objectives, and field studies are far fewer. A major limitation is insufficient funding, the main causes of which we analyze. We argue, however, that fieldwork is a key driver in generating new scientific knowledge as part of a One Health approach, by observing/documenting and understanding the diverse and largely unexplored biological processes evolved by animals adapted to unusual environmental conditions, which would be extreme conditions for humans. These conditions do not only refer to extreme temperatures, since lack of food or water, high pressures or lack of oxygen, are clearly extreme constraints. To conduct this research, there are serious limitations we propose to address. Specific techniques and methods are requested, not only to work in extreme environments, but also to minimize the ecological footprint of field work. The erosion of biodiversity is a major threat. The reduction of animal disturbance, a key issue, requires specific technologies and expertise. An ethical approach is requested, for the sake of transparency and to comply with the Nagoya Protocol on genetic resources. An interdisciplinary expertise and a meticulous planning are requested to overcome the field constraints and interface the associated laboratory work. We recommend focusing on the major threats to global human health today, which wild animals appear to resist particularly well, such as antibioresistance and diseases associated with lifestyle and senescence.</div></div>","PeriodicalId":101146,"journal":{"name":"Science in One Health","volume":"4 ","pages":"Article 100096"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11773462/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143061868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nipah virus outbreak trends in Bangladesh during the period 2001 to 2024: a brief review

Science in One Health

Pub Date : 2025-01-01 DOI: 10.1016/j.soh.2024.100103

Awnon Bhowmik , Mahmudul Hasan , Md. Mehedi Hasan Redoy , Goutam Saha

Nipah virus (NiV) is a zoonotic threat that has caused recurrent outbreaks in Bangladesh since 2001, raising significant public health concerns. This study provides a descriptive analysis of NiV outbreaks from 2001 to 2024, examining trends in infection and death rates and their correlation with climatic factors such as temperature, humidity, and rainfall. The findings highlight significant spikes in NiV cases during specific years, with environmental factors, particularly temperature and precipitation, showing solid correlations with outbreak patterns. The study also explores the impact of population dynamics on transmission risks, including urbanization and density. By focusing on these factors, this research supports the development of targeted public health interventions in high-risk areas, particularly in Bangladesh's northwestern and central districts, where recurrent outbreaks have been observed. These insights improve surveillance and preventive strategies for mitigating future NiV outbreaks.

引用次数: 0

Mpox (monkeypox): a comprehensive updated of current epidemic evidence

Science in One Health

Pub Date : 2025-01-01 DOI: 10.1016/j.soh.2024.100100

Amir Hossain , Md. Abdul Monem , Mamunur Rahman , Rashadur Raza

Mpox, formerly referred to as monkeypox, is a viral disease endemic to central Africa, resulting from the monkeypox virus (MPXV). This study provides a current overview of the Mpox epidemic as of 2024, emphasizing significant developments and epidemiological trends. The World Health Organization (WHO) initially designated a clade Ⅱb outbreak as a global health emergency in May 2022, which was subsequently managed through vaccination and public health interventions by May 2023. In September 2023, a resurgence of cladeⅠ in the Democratic Republic of the Congo (DRC) resulted in a 160 % increase in cases by 2024. The WHO declared this increase a public health emergency of international concern (PHEIC) in August 2024. The outbreak timeline indicates substantial rises in cases and fatalities, especially among children under 15 in the DRC. Regional analysis reveals that the European Region initially recorded the highest incidence of cases and fatalities. In contrast, regions including African Region (AFRO), Eastern Mediterranean Region (EMRO), South-East Asia Region (SEARO), and Western Pacific Region (WPRO) exhibited a rise in cases, indicating a potential spread or resurgence of the health event. Gender disparities in transmission pathways were apparent, with males exhibiting higher case numbers, particularly via person-to-person contact. The research highlights the necessity of ongoing surveillance, global collaboration, and focused public health measures. The discourse addresses obstacles in vaccine distribution and the necessity for emergency use authorizations, highlighting the imperativeness for adaptive strategies in public health management. This extensive update offers critical insights into the present condition of the Mpox epidemic and the necessary measures to mitigate its proliferation.

{"title":"Mpox (monkeypox): a comprehensive updated of current epidemic evidence","authors":"Amir Hossain , Md. Abdul Monem , Mamunur Rahman , Rashadur Raza","doi":"10.1016/j.soh.2024.100100","DOIUrl":"10.1016/j.soh.2024.100100","url":null,"abstract":"<div><div>Mpox, formerly referred to as monkeypox, is a viral disease endemic to central Africa, resulting from the monkeypox virus (MPXV). This study provides a current overview of the Mpox epidemic as of 2024, emphasizing significant developments and epidemiological trends. The World Health Organization (WHO) initially designated a clade Ⅱb outbreak as a global health emergency in May 2022, which was subsequently managed through vaccination and public health interventions by May 2023. In September 2023, a resurgence of cladeⅠ in the Democratic Republic of the Congo (DRC) resulted in a 160 % increase in cases by 2024. The WHO declared this increase a public health emergency of international concern (PHEIC) in August 2024. The outbreak timeline indicates substantial rises in cases and fatalities, especially among children under 15 in the DRC. Regional analysis reveals that the European Region initially recorded the highest incidence of cases and fatalities. In contrast, regions including African Region (AFRO), Eastern Mediterranean Region (EMRO), South-East Asia Region (SEARO), and Western Pacific Region (WPRO) exhibited a rise in cases, indicating a potential spread or resurgence of the health event. Gender disparities in transmission pathways were apparent, with males exhibiting higher case numbers, particularly via person-to-person contact. The research highlights the necessity of ongoing surveillance, global collaboration, and focused public health measures. The discourse addresses obstacles in vaccine distribution and the necessity for emergency use authorizations, highlighting the imperativeness for adaptive strategies in public health management. This extensive update offers critical insights into the present condition of the Mpox epidemic and the necessary measures to mitigate its proliferation.</div></div>","PeriodicalId":101146,"journal":{"name":"Science in One Health","volume":"4 ","pages":"Article 100100"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11764110/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143054726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Strategy and mechanism of One Health governance: case study of China

Science in One Health

Pub Date : 2025-01-01 DOI: 10.1016/j.soh.2024.100098

Xinchen Li , Yanyan Zhang , Qiyu Zhang , Jingshu Liu , Zelin Zhu , Xinyu Feng , Lefei Han , Xiaoxi Zhang

Background

Strategy and mechanism are crucial components of One Health governance in China, designed to address the interconnected health issues between humans, animals, and the environment. This study aims to evaluate China's current One Health governance framework, identify key strengths and gaps, and provide recommendations for establishing a more integrated and effective system.

Methods

A qualitative approach was employed, including in-depth interviews, policy analysis, and a review of existing literature, to evaluate the strengths and gaps in China's One Health framework.

Results

The analysis identified progress and challenges in six key areas: (1) political commitment: strong national support exists, but lacks a unified strategy; (2) legislation and regulation: notable legislative efforts are in place, yet they remain fragmented; (3) leadership building: effective leadership structures have been established during crises but are not institutionalized; (4) strategic planning: initial regional planning is underway, but a comprehensive national focus is needed; (5) coordination and communication: mechanisms exist but require formalized, consistent information-sharing channels; (6) stakeholder engagement: public and academic awareness is growing, yet local community involvement needs strengthening.

Conclusion

To advance its One Health governance, China must focus on creating a unified strategy, enhancing interdepartmental coordination, and deepening stakeholder engagement, ensuring its alignment with international standards and improving public health outcomes.

{"title":"Strategy and mechanism of One Health governance: case study of China","authors":"Xinchen Li , Yanyan Zhang , Qiyu Zhang , Jingshu Liu , Zelin Zhu , Xinyu Feng , Lefei Han , Xiaoxi Zhang","doi":"10.1016/j.soh.2024.100098","DOIUrl":"10.1016/j.soh.2024.100098","url":null,"abstract":"<div><h3>Background</h3><div>Strategy and mechanism are crucial components of One Health governance in China, designed to address the interconnected health issues between humans, animals, and the environment. This study aims to evaluate China's current One Health governance framework, identify key strengths and gaps, and provide recommendations for establishing a more integrated and effective system.</div></div><div><h3>Methods</h3><div>A qualitative approach was employed, including in-depth interviews, policy analysis, and a review of existing literature, to evaluate the strengths and gaps in China's One Health framework.</div></div><div><h3>Results</h3><div>The analysis identified progress and challenges in six key areas: (1) political commitment: strong national support exists, but lacks a unified strategy; (2) legislation and regulation: notable legislative efforts are in place, yet they remain fragmented; (3) leadership building: effective leadership structures have been established during crises but are not institutionalized; (4) strategic planning: initial regional planning is underway, but a comprehensive national focus is needed; (5) coordination and communication: mechanisms exist but require formalized, consistent information-sharing channels; (6) stakeholder engagement: public and academic awareness is growing, yet local community involvement needs strengthening.</div></div><div><h3>Conclusion</h3><div>To advance its One Health governance, China must focus on creating a unified strategy, enhancing interdepartmental coordination, and deepening stakeholder engagement, ensuring its alignment with international standards and improving public health outcomes.</div></div>","PeriodicalId":101146,"journal":{"name":"Science in One Health","volume":"4 ","pages":"Article 100098"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11786842/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143081889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk assessment of emerging infectious diseases in China under the One Health framework

Science in One Health

Pub Date : 2025-01-01 DOI: 10.1016/j.soh.2025.100104

Ne Qiang , Tianyun Li , Lijun Jia , Zelin Zhu , Xinyu Feng , Jinjun Ran , Xiaoxi Zhang , Lefei Han

Background

Emerging infectious diseases (EIDs) pose significant public health challenges due to increasing interactions between humans, animals, and the environment. The One Health framework, an interdisciplinary and collaborative approach, plays a critical role in the risk assessment of EIDs. The study aims to systematically review the risk assessment of EIDs in China under the One Health framework, covering policy support, monitoring and assessment systems, and implementation methods.

Methods

Relevant literature and official documents between 1997 and 2024 were retrieved from Web of Science, PubMed, Scopus, China National Knowledge Infrastructure, Wan Fang, China Science and Technology Journal Database, and government websites. Data were synthesized to analyze progress, challenges, and gaps.

Results

There were 43 academic studies and 31 official documents included in this review. The study found that risk assessment systems existed across human, animal, and environmental health sectors in China, and the government was advancing intelligent monitoring and fostering inter-departmental cooperation. However, several challenges remain in risk assessment of EIDs, including inadequate monitoring systems for unknown EIDs, limited capacity building for risk assessment in ecosystems and environmental systems, insufficiently detailed risk assessment guidance at the county level, and barriers to cross-sectoral information sharing at the international and county levels.

Conclusion

The findings highlighted the need to enhance risk assessment of EIDs at the local level, expand the scope of disease surveillance including aquatic and wild animals, and strengthen inter-departmental data sharing to improve early warning capabilities under the One Health framework.

{"title":"Risk assessment of emerging infectious diseases in China under the One Health framework","authors":"Ne Qiang , Tianyun Li , Lijun Jia , Zelin Zhu , Xinyu Feng , Jinjun Ran , Xiaoxi Zhang , Lefei Han","doi":"10.1016/j.soh.2025.100104","DOIUrl":"10.1016/j.soh.2025.100104","url":null,"abstract":"<div><h3>Background</h3><div>Emerging infectious diseases (EIDs) pose significant public health challenges due to increasing interactions between humans, animals, and the environment. The One Health framework, an interdisciplinary and collaborative approach, plays a critical role in the risk assessment of EIDs. The study aims to systematically review the risk assessment of EIDs in China under the One Health framework, covering policy support, monitoring and assessment systems, and implementation methods.</div></div><div><h3>Methods</h3><div>Relevant literature and official documents between 1997 and 2024 were retrieved from Web of Science, PubMed, Scopus, China National Knowledge Infrastructure, Wan Fang, China Science and Technology Journal Database, and government websites. Data were synthesized to analyze progress, challenges, and gaps.</div></div><div><h3>Results</h3><div>There were 43 academic studies and 31 official documents included in this review. The study found that risk assessment systems existed across human, animal, and environmental health sectors in China, and the government was advancing intelligent monitoring and fostering inter-departmental cooperation. However, several challenges remain in risk assessment of EIDs, including inadequate monitoring systems for unknown EIDs, limited capacity building for risk assessment in ecosystems and environmental systems, insufficiently detailed risk assessment guidance at the county level, and barriers to cross-sectoral information sharing at the international and county levels.</div></div><div><h3>Conclusion</h3><div>The findings highlighted the need to enhance risk assessment of EIDs at the local level, expand the scope of disease surveillance including aquatic and wild animals, and strengthen inter-departmental data sharing to improve early warning capabilities under the One Health framework.</div></div>","PeriodicalId":101146,"journal":{"name":"Science in One Health","volume":"4 ","pages":"Article 100104"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143403471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence and antibiotic resistance patterns of Pseudomonas aeruginosa and Acinetobacter baumannii strains isolated from chicken droppings on poultry farms in Gondar city, Northwest Ethiopia

Science in One Health

Pub Date : 2025-01-01 DOI: 10.1016/j.soh.2024.100099

Mitkie Tigabie , Muluneh Assefa , Yalewayker Gashaw , Azanaw Amare , Aklilu Ambachew , Sirak Biset , Feleke Moges

<div><h3>Background</h3><div><em>Pseudomonas aeruginosa</em> and <em>Acinetobacter baumannii</em> are common nosocomial pathogens in hospital settings. Recently, they have also been found in non-hospital environments, such as poultry farms. While most studies in Ethiopia have focused on these bacteria's antibiotic resistance patterns in hospitals, information regarding their prevalence and resistance in veterinary settings, particularly poultry farms, is limited. This study aimed to assess the prevalence and antibiotic resistance patterns of <em>P. aeruginosa</em> and <em>A. baumannii</em> isolated from chicken droppings on poultry farms.</div></div><div><h3>Methods</h3><div>A cross-sectional study was conducted from March 2022 to June 2022. A total of 87 poultry farms were included in this study, and pooled chicken dropping samples were collected. The samples were subsequently transferred to buffered peptone water and cultured on MacConkey agar. Species of the isolates were identified via routine biochemical tests, including oxidase, catalase, urease, Simon's citrate, sulfide indole motility medium, triple sugar iron agar and growth at temperatures of 37 °C and 42 °C. The Kirby–Bauer disk diffusion technique was used for antibiotic susceptibility testing. The data were entered into <em>EpiData</em> version 4.6 and then exported to <em>SPSS</em> version 26 for analysis. Fisher's exact test was used to observe an appropriate association between independent variables and the occurrence of isolates. The results are presented in the text, figures and tables.</div></div><div><h3>Results</h3><div>Among the 87 poultry farms, 41 (47.1 %) were positive for <em>Pseudomonas</em> and <em>Acinetobacter</em>. Among these strains, 24 (27.6 %) <em>P. aeruginosa</em> strains and 13 (14.9 %) <em>A. baumannii</em> strains were recovered. <em>P. aeruginosa</em> showed complete resistance to tetracycline (24, 100.0 %) and trimethoprim-sulfamethoxazole (24, 100.0 %). Additionally, there was a high rate of resistance to ciprofloxacin (13, 54.2 %) and amikacin (12, 50.0 %). Similarly, 13 (100.0 %) <em>A. baumannii</em> isolates were resistant to tetracycline, and 12 (92.3 %) were resistant to trimethoprim-sulfamethoxazole. However, both isolates presented lower resistance rates to piperacillin-tazobactam (4, 9.8 %) and cefepime (7, 17.1 %). Both <em>A. baumannii</em> and <em>P. aeruginosa</em> exhibited multidrug resistance in 10/13 (76.9 %) and 16/24 (66.7 %) of the strains, respectively. The overall prevalence of multidrug resistance in this study was 28/41 (68.3 %).</div></div><div><h3>Conclusion</h3><div>This study demonstrated that poultry farms may be potential reservoirs for <em>P. aeruginosa</em> and <em>A. baumannii,</em> including antibiotic-resistant strains. This is a significant concern to public health because poultry farmers may be contaminated, increasing their dissemination to the community. Therefore, poultry farmers should improve sanitation and reduc

{"title":"Prevalence and antibiotic resistance patterns of Pseudomonas aeruginosa and Acinetobacter baumannii strains isolated from chicken droppings on poultry farms in Gondar city, Northwest Ethiopia","authors":"Mitkie Tigabie , Muluneh Assefa , Yalewayker Gashaw , Azanaw Amare , Aklilu Ambachew , Sirak Biset , Feleke Moges","doi":"10.1016/j.soh.2024.100099","DOIUrl":"10.1016/j.soh.2024.100099","url":null,"abstract":"<div><h3>Background</h3><div><em>Pseudomonas aeruginosa</em> and <em>Acinetobacter baumannii</em> are common nosocomial pathogens in hospital settings. Recently, they have also been found in non-hospital environments, such as poultry farms. While most studies in Ethiopia have focused on these bacteria's antibiotic resistance patterns in hospitals, information regarding their prevalence and resistance in veterinary settings, particularly poultry farms, is limited. This study aimed to assess the prevalence and antibiotic resistance patterns of <em>P. aeruginosa</em> and <em>A. baumannii</em> isolated from chicken droppings on poultry farms.</div></div><div><h3>Methods</h3><div>A cross-sectional study was conducted from March 2022 to June 2022. A total of 87 poultry farms were included in this study, and pooled chicken dropping samples were collected. The samples were subsequently transferred to buffered peptone water and cultured on MacConkey agar. Species of the isolates were identified via routine biochemical tests, including oxidase, catalase, urease, Simon's citrate, sulfide indole motility medium, triple sugar iron agar and growth at temperatures of 37 °C and 42 °C. The Kirby–Bauer disk diffusion technique was used for antibiotic susceptibility testing. The data were entered into <em>EpiData</em> version 4.6 and then exported to <em>SPSS</em> version 26 for analysis. Fisher's exact test was used to observe an appropriate association between independent variables and the occurrence of isolates. The results are presented in the text, figures and tables.</div></div><div><h3>Results</h3><div>Among the 87 poultry farms, 41 (47.1 %) were positive for <em>Pseudomonas</em> and <em>Acinetobacter</em>. Among these strains, 24 (27.6 %) <em>P. aeruginosa</em> strains and 13 (14.9 %) <em>A. baumannii</em> strains were recovered. <em>P. aeruginosa</em> showed complete resistance to tetracycline (24, 100.0 %) and trimethoprim-sulfamethoxazole (24, 100.0 %). Additionally, there was a high rate of resistance to ciprofloxacin (13, 54.2 %) and amikacin (12, 50.0 %). Similarly, 13 (100.0 %) <em>A. baumannii</em> isolates were resistant to tetracycline, and 12 (92.3 %) were resistant to trimethoprim-sulfamethoxazole. However, both isolates presented lower resistance rates to piperacillin-tazobactam (4, 9.8 %) and cefepime (7, 17.1 %). Both <em>A. baumannii</em> and <em>P. aeruginosa</em> exhibited multidrug resistance in 10/13 (76.9 %) and 16/24 (66.7 %) of the strains, respectively. The overall prevalence of multidrug resistance in this study was 28/41 (68.3 %).</div></div><div><h3>Conclusion</h3><div>This study demonstrated that poultry farms may be potential reservoirs for <em>P. aeruginosa</em> and <em>A. baumannii,</em> including antibiotic-resistant strains. This is a significant concern to public health because poultry farmers may be contaminated, increasing their dissemination to the community. Therefore, poultry farmers should improve sanitation and reduc","PeriodicalId":101146,"journal":{"name":"Science in One Health","volume":"4 ","pages":"Article 100099"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143163118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrated surveillance and early warning system of emerging infectious diseases in China at community level: current status, gaps and perspectives

Science in One Health

Pub Date : 2025-01-01 DOI: 10.1016/j.soh.2024.100102

Chenjia Zhou , Suping Wang , Chenxi Wang , Ne Qiang , Leshan Xiu , Qinqin Hu , Wenyu Wu , Xiaoxi Zhang , Lefei Han , Xinyu Feng , Zelin Zhu , Leilei Shi , Peng Zhang , Kun Yin

Emerging infectious diseases (EIDs) pose a significant threat to public health. Effective surveillance and early warning systems that monitor EIDs in a timely manner are crucial for their control. Given that more than half of EIDs are zoonotic, traditional integrated surveillance systems remain inadequate. Despite recent advances in integrated systems in China, there are few systemic reviews on the integrated surveillance and early warning system of EIDs at community level, particularly under the One Health framework. Here, this systematic review summarizes the current status of surveillance advances in China, including the multi-trigger integrated monitor system. It also highlights the mechanisms for embedding the One Health approach into local policy and practice, while identifying challenges and opportunities for improvement. Additionally, guidelines and recommendations are proposed to optimize the integration of multi-sectoral, multi-level and interdisciplinary cooperation at the human–animal–environment interface.

{"title":"Integrated surveillance and early warning system of emerging infectious diseases in China at community level: current status, gaps and perspectives","authors":"Chenjia Zhou , Suping Wang , Chenxi Wang , Ne Qiang , Leshan Xiu , Qinqin Hu , Wenyu Wu , Xiaoxi Zhang , Lefei Han , Xinyu Feng , Zelin Zhu , Leilei Shi , Peng Zhang , Kun Yin","doi":"10.1016/j.soh.2024.100102","DOIUrl":"10.1016/j.soh.2024.100102","url":null,"abstract":"<div><div>Emerging infectious diseases (EIDs) pose a significant threat to public health. Effective surveillance and early warning systems that monitor EIDs in a timely manner are crucial for their control. Given that more than half of EIDs are zoonotic, traditional integrated surveillance systems remain inadequate. Despite recent advances in integrated systems in China, there are few systemic reviews on the integrated surveillance and early warning system of EIDs at community level, particularly under the One Health framework. Here, this systematic review summarizes the current status of surveillance advances in China, including the multi-trigger integrated monitor system. It also highlights the mechanisms for embedding the One Health approach into local policy and practice, while identifying challenges and opportunities for improvement. Additionally, guidelines and recommendations are proposed to optimize the integration of multi-sectoral, multi-level and interdisciplinary cooperation at the human–animal–environment interface.</div></div>","PeriodicalId":101146,"journal":{"name":"Science in One Health","volume":"4 ","pages":"Article 100102"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143454718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mismatched online public concern and tick-borne disease risk in China

Science in One Health

Pub Date : 2025-01-01 DOI: 10.1016/j.soh.2024.100101

Yuxin Li , Tengfei Hu , Tingting Wang , Sen Li

Introduction

Ticks and tick-borne diseases are increasing public health concerns in China. This study examines public awareness and concern using data from the People Cloud, a national public opinion data platform.

Methods

We analyzed 358,862 posts related to ticks, tick bites, Lyme disease, and tick-borne encephalitis from October 2022 to November 2023. Temporal trends and geographic distribution were assessed to identify patterns of public interest.

Results

Public concern peaked in April, coinciding with tick season, with “ticks” being the most mentioned term, particularly on social media platforms, such as WeChat. High search activity was concentrated in southeastern and northern provinces, especially Zhejiang, Guangdong, and Jiangsu. Lyme disease posts were more dispersed, while tick-borne encephalitis posts clustered in southern areas.

Conclusion

Public interest in ticks follows seasonal and regional trends, reflecting tick activity but not always matching disease risk or tick distribution. Monitoring public opinion data can guide targeted health interventions and improve disease prevention efforts.

{"title":"Mismatched online public concern and tick-borne disease risk in China","authors":"Yuxin Li , Tengfei Hu , Tingting Wang , Sen Li","doi":"10.1016/j.soh.2024.100101","DOIUrl":"10.1016/j.soh.2024.100101","url":null,"abstract":"<div><h3>Introduction</h3><div>Ticks and tick-borne diseases are increasing public health concerns in China. This study examines public awareness and concern using data from the People Cloud, a national public opinion data platform.</div></div><div><h3>Methods</h3><div>We analyzed 358,862 posts related to ticks, tick bites, Lyme disease, and tick-borne encephalitis from October 2022 to November 2023. Temporal trends and geographic distribution were assessed to identify patterns of public interest.</div></div><div><h3>Results</h3><div>Public concern peaked in April, coinciding with tick season, with “ticks” being the most mentioned term, particularly on social media platforms, such as WeChat. High search activity was concentrated in southeastern and northern provinces, especially Zhejiang, Guangdong, and Jiangsu. Lyme disease posts were more dispersed, while tick-borne encephalitis posts clustered in southern areas.</div></div><div><h3>Conclusion</h3><div>Public interest in ticks follows seasonal and regional trends, reflecting tick activity but not always matching disease risk or tick distribution. Monitoring public opinion data can guide targeted health interventions and improve disease prevention efforts.</div></div>","PeriodicalId":101146,"journal":{"name":"Science in One Health","volume":"4 ","pages":"Article 100101"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143163016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Global burden of HIV-negative multidrug- and extensively drug-resistant tuberculosis based on Global Burden of Disease Study 2021 基于 2021 年全球疾病负担研究的艾滋病毒阴性耐多药和广泛耐药结核病的全球负担

Science in One Health

Pub Date : 2024-01-01 DOI: 10.1016/j.soh.2024.100072

Yiming Chen , Weiye Chen , Zile Cheng , Yiwen Chen , Min Li , Lingchao Ma , Nan Zhou , Jing Qian , Yongzhang Zhu , Chang Liu

Background

Tuberculosis (TB), caused by Mycobacterium tuberculosis, remains the second leading cause of death from a single infectious disease globally and poses a significant economic and clinical burden in the world in 2022. Of particular concern is the emergence of drug-resistant TB, accounting for 15%–20% of TB deaths. It is imperative to delve into the global trends of incidence and death rate for multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB), drawing upon the comprehensive Global Burden of Disease (GBD) 2021 drug-resistant tuberculosis dataset.

Methods

From the GBD 2021, data on incidence, prevalence, disability-adjusted life years (DALYs), and death of MDR-TB and XDR-TB from 1990 to 2021 were collected. We calculated the estimated annual percentage changes in age standardized incidence rate (ASIR) and age-standardized death rate (ASDR), segmented by age, sex, and Socio-demographic Index (SDI). The impacts of various risk factors on MDR-TB and XDR-TB were also analyzed.

Results

In 2021, there were an estimated 443,680 (95% uncertainty interval [UI]: 259,196–766,545) incident cases of MDR-TB, and an estimated 106,818 (95% UI: 41,612–211,854) death cases of MDR-TB, while there were an estimated 24,036 (95% UI: 17,144–34,587) incident cases of XDR-TB and 7,946 (95% UI: 3,326–14,859) death cases of XDR-TB. The incidence and death cases of MDR-TB were lowest in high SDI regions, whereas the incidence rates of XDR-TB in high-middle SDI regions were higher than those in middle SDI and high SDI regions.

Conclusion

This study reported the disease burden of drug-resistant TB from 1990 to 2021. Until 2021, drug-resistant TB is still a serious problem in low SDI countries, especially for high-risk age populations with high-risk factors. Controlling drug-resistant TB requires effective control strategies and healthcare systems.

背景由结核分枝杆菌引起的结核病（TB）仍然是全球单一传染病的第二大死因，并将在 2022 年对世界造成巨大的经济和临床负担。耐药性结核病的出现尤其令人担忧，它占结核病死亡人数的 15%-20%。当务之急是利用 2021 年全球疾病负担（GBD）耐药结核病综合数据集，深入研究耐多药结核病（MDR-TB）和广泛耐药结核病（XDR-TB）的全球发病率和死亡率趋势。我们计算了按年龄、性别和社会人口指数（SDI）划分的年龄标准化发病率（ASIR）和年龄标准化死亡率（ASDR）的估计年度百分比变化。还分析了各种风险因素对 MDR-TB 和 XDR-TB 的影响。结果 2021 年，估计有 443,680 例（95% 不确定区间 [UI]：259,196-766,545）MDR-TB 发病病例和 106,818 例（95% 不确定区间 [UI]：41,612-211,854）MDR-TB 死亡病例，而估计有 24,036 例（95% 不确定区间 [UI]：17,144-34,587）XDR-TB 发病病例和 7,946 例（95% 不确定区间 [UI]：3,326-14,859）XDR-TB 死亡病例。MDR-TB 的发病率和死亡病例在高 SDI 地区最低，而 XDR-TB 在中高 SDI 地区的发病率高于中 SDI 和高 SDI 地区。直到 2021 年，耐药结核病在低 SDI 国家仍然是一个严重的问题，尤其是在具有高危因素的高危年龄人群中。控制耐药结核病需要有效的控制策略和医疗保健系统。

{"title":"Global burden of HIV-negative multidrug- and extensively drug-resistant tuberculosis based on Global Burden of Disease Study 2021","authors":"Yiming Chen , Weiye Chen , Zile Cheng , Yiwen Chen , Min Li , Lingchao Ma , Nan Zhou , Jing Qian , Yongzhang Zhu , Chang Liu","doi":"10.1016/j.soh.2024.100072","DOIUrl":"10.1016/j.soh.2024.100072","url":null,"abstract":"<div><h3>Background</h3><p>Tuberculosis (TB), caused by <em>Mycobacterium tuberculosis</em>, remains the second leading cause of death from a single infectious disease globally and poses a significant economic and clinical burden in the world in 2022. Of particular concern is the emergence of drug-resistant TB, accounting for 15%–20% of TB deaths. It is imperative to delve into the global trends of incidence and death rate for multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB), drawing upon the comprehensive Global Burden of Disease (GBD) 2021 drug-resistant tuberculosis dataset.</p></div><div><h3>Methods</h3><p>From the GBD 2021, data on incidence, prevalence, disability-adjusted life years (DALYs), and death of MDR-TB and XDR-TB from 1990 to 2021 were collected. We calculated the estimated annual percentage changes in age standardized incidence rate (ASIR) and age-standardized death rate (ASDR), segmented by age, sex, and Socio-demographic Index (SDI). The impacts of various risk factors on MDR-TB and XDR-TB were also analyzed.</p></div><div><h3>Results</h3><p>In 2021, there were an estimated 443,680 (95% uncertainty interval [<em>UI</em>]: 259,196–766,545) incident cases of MDR-TB, and an estimated 106,818 (95% <em>UI</em>: 41,612–211,854) death cases of MDR-TB, while there were an estimated 24,036 (95% <em>UI</em>: 17,144–34,587) incident cases of XDR-TB and 7,946 (95% <em>UI</em>: 3,326–14,859) death cases of XDR-TB. The incidence and death cases of MDR-TB were lowest in high SDI regions, whereas the incidence rates of XDR-TB in high-middle SDI regions were higher than those in middle SDI and high SDI regions.</p></div><div><h3>Conclusion</h3><p>This study reported the disease burden of drug-resistant TB from 1990 to 2021. Until 2021, drug-resistant TB is still a serious problem in low SDI countries, especially for high-risk age populations with high-risk factors. Controlling drug-resistant TB requires effective control strategies and healthcare systems.</p></div>","PeriodicalId":101146,"journal":{"name":"Science in One Health","volume":"3 ","pages":"Article 100072"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949704324000118/pdfft?md5=521aef4f703bbd32d1a1bd9b547f2d92&pid=1-s2.0-S2949704324000118-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141693978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dietary exposure assessment of perchlorate and chlorate in infant formulas marketed in Shanghai, China 中国上海市场上销售的婴儿配方奶粉中高氯酸盐和氯酸盐的膳食暴露评估

Science in One Health

Pub Date : 2024-01-01 DOI: 10.1016/j.soh.2024.100062

Shenghao Yu , Yonghui Ge , Lujing Zhang , Yiqi Li , Wen Zhang , Chang Liu , Shaojie Peng

Perchlorate and chlorate are ubiquitous pollutants that can adversely affect the thyroid function in humans. This study assessed the potential health risks associated with the dietary exposure of infants and young children to perchlorate and chlorate present in infant formulas available in Shanghai. The assessment was based on risk monitoring data from 150 samples of infant formulas in Shanghai between 2020 and 2022, along with the dietary consumption data of infants and young children. The detection rates of perchlorate and chlorate in infant formulas were 46.0% and 98.7%, with mean contents of 9.98 μg/kg and 112.01 μg/kg, and the maximum values of 151.00 μg/kg and 1475.00 μg/kg, respectively. The mean and 95th percentile (P₉₅) values of daily perchlorate exposure of 0–36-month-old infant and young children via infant formulas were 0.07 and 0.17 μg/kg body weight (bw) per day, respectively, which were lower than the tolerable daily intake (TDI) of perchlorate (0.3 μg/kg bw per day). The mean and P₉₅ values of chlorate exposure via infant formulas in 0–36-month-old infants and young children were 0.83 and 1.89 μg/kg bw per day, which were lower than the TDI of chlorate (3 μg/kg bw per day). The P₉₅ exposure of different age groups (0–6 months, 7–12 months and 13–36 months) of infants and young children to perchlorate and chlorate in infant formulas was below the TDI. Therefore, the risk associated with the exposure of 0–36-month-old infants and young children to perchlorate and chlorate from infant formulas in Shanghai is considered acceptable. Prioritizing environmental pollution control efforts to reduce the levels of perchlorate and chlorate in food products is important to safeguard the health of the infants and children under the One Health concept.

高氯酸盐和氯酸盐是无处不在的污染物，会对人体的甲状腺功能产生不利影响。本研究评估了婴幼儿从膳食中暴露于上海婴幼儿配方奶粉中的高氯酸盐和氯酸盐可能带来的健康风险。该评估基于2020年至2022年期间上海150份婴幼儿配方奶粉样品的风险监测数据，以及婴幼儿的膳食消费数据。结果显示，婴幼儿配方奶粉中高氯酸盐和氯酸盐的检出率分别为46.0%和98.7%，平均含量分别为9.98微克/千克和112.01微克/千克，最大含量分别为151.00微克/千克和1475.00微克/千克。0 至 36 个月大的婴幼儿每天从婴儿配方奶粉摄入高氯酸盐的平均值和第 95 百分位数（P95）分别为每公斤体重 0.07 微克和 0.17 微克，低于高氯酸盐的每日可容忍摄入量（每日每公斤体重 0.3 微克）。0 至 36 个月大的婴幼儿从婴儿配方奶粉摄入氯酸盐的平均值和 P95 值分别为每日每公斤体重 0.83 微克和 1.89 微克，低于氯酸盐的每日可容忍摄入量（每日每公斤体重 3 微克）。不同年龄组别（0 至 6 个月、7 至 12 个月和 13 至 36 个月）的婴幼儿从婴儿配方奶粉摄入高氯酸盐和氯酸盐的 P95 分量，均低于总摄入量参考值。因此，上海 0-36 个月大的婴幼儿接触婴儿配方奶粉中的高氯酸盐和氯酸盐的风险是可以接受的。在 "同一健康 "理念下，优先开展环境污染控制工作，降低食品中的高氯酸盐和氯酸盐含量，对于保障婴幼儿健康非常重要。

{"title":"Dietary exposure assessment of perchlorate and chlorate in infant formulas marketed in Shanghai, China","authors":"Shenghao Yu , Yonghui Ge , Lujing Zhang , Yiqi Li , Wen Zhang , Chang Liu , Shaojie Peng","doi":"10.1016/j.soh.2024.100062","DOIUrl":"10.1016/j.soh.2024.100062","url":null,"abstract":"<div><p>Perchlorate and chlorate are ubiquitous pollutants that can adversely affect the thyroid function in humans. This study assessed the potential health risks associated with the dietary exposure of infants and young children to perchlorate and chlorate present in infant formulas available in Shanghai. The assessment was based on risk monitoring data from 150 samples of infant formulas in Shanghai between 2020 and 2022, along with the dietary consumption data of infants and young children. The detection rates of perchlorate and chlorate in infant formulas were 46.0% and 98.7%, with mean contents of 9.98 μg/kg and 112.01 μg/kg, and the maximum values of 151.00 μg/kg and 1475.00 μg/kg, respectively. The mean and 95th percentile (<em>P</em><sub>95</sub>) values of daily perchlorate exposure of 0–36-month-old infant and young children via infant formulas were 0.07 and 0.17 μg/kg body weight (bw) per day, respectively, which were lower than the tolerable daily intake (TDI) of perchlorate (0.3 μg/kg bw per day). The mean and <em>P</em><sub>95</sub> values of chlorate exposure via infant formulas in 0–36-month-old infants and young children were 0.83 and 1.89 μg/kg bw per day, which were lower than the TDI of chlorate (3 μg/kg bw per day). The <em>P</em><sub>95</sub> exposure of different age groups (0–6 months, 7–12 months and 13–36 months) of infants and young children to perchlorate and chlorate in infant formulas was below the TDI. Therefore, the risk associated with the exposure of 0–36-month-old infants and young children to perchlorate and chlorate from infant formulas in Shanghai is considered acceptable. Prioritizing environmental pollution control efforts to reduce the levels of perchlorate and chlorate in food products is important to safeguard the health of the infants and children under the One Health concept.</p></div>","PeriodicalId":101146,"journal":{"name":"Science in One Health","volume":"3 ","pages":"Article 100062"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2949704324000015/pdfft?md5=23155952d0e7b28f4b7a19e3fd32b52f&pid=1-s2.0-S2949704324000015-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139634859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0