Science in One Health最新文献

Seasonal dynamics, antimicrobial resistance, and genetic lineages of thermotolerant Campylobacter isolates from South American camelids 季节动态，抗菌素耐药性，以及从南美骆驼中分离的耐热弯曲杆菌的遗传谱系

Science in One Health

Pub Date : 2026-01-01 DOI: 10.1016/j.soh.2026.100147

Aung Zaw Moe , Carsten Heydel , Henrik Wagner , Lisa Ulrich , Torsten Semmler , Kerstin Stingl , Priyanshu Singh Raikwar , Samuel K. Sheppard , Christa Ewers

Background

South American camelids (SACs) are increasingly kept as companion animals, but their role in zoonotic transmission is poorly understood. Thermotolerant Campylobacter spp. are a leading cause of bacterial zoonoses globally. This study investigated the occurrence and zoonotic potential of thermotolerant Campylobacter spp. in SACs on German farms.

Methods

Fecal swabs from up to 20 animals on 10 farms were collected across four seasons. Campylobacter spp. were isolated, and genomes were typed to assess multilocus sequence types (STs), virulence, and antimicrobial resistance.

Results

Campylobacter spp. were detected in 23/717 samples (3.2 %), including 16 Campylobacter jejuni from seven farms and seven Campylobacter coli from two farms. Detection was higher in alpacas (4.9 %, 21/427) than in llamas (0.7 %, 2/288), with higher rates in summer. Molecular typing revealed high genetic heterogeneity, though some STs recurred across timepoints, animals, and farms, suggesting potential endemic colonization. Nine distinct C. jejuni STs and two C. coli STs were identified, many belonging to clonal complexes (CCs) common in livestock and humans. All isolates carried virulence-associated genes for motility, adhesion, invasion, and toxin production, while several from CC21 harbored genes linked to Guillain-Barré syndrome. Antimicrobial susceptibility testing showed wild-type phenotypes for erythromycin, gentamicin, and chloramphenicol. Ciprofloxacin resistance, with T86I mutation in gyrA, was found in three isolates; one C. jejuni isolate carried tet(O) conferring tetracycline resistance.

Conclusion

SACs harbor Campylobacter strains related to human and livestock lineages, with virulence and resistance traits relevant for zoonotic transmission. Their presence on German farms highlights the need targeted surveillance and biosecurity within a One Health framework.

越来越多的人将南美骆驼作为伴侣动物饲养，但人们对它们在人畜共患疾病传播中的作用知之甚少。耐热弯曲杆菌是全球细菌性人畜共患病的主要原因。本研究调查了德国农场SACs中耐热弯曲杆菌的发生情况和人畜共患的可能性。方法收集10个农场4个季节20只动物的粪便拭子。分离出弯曲杆菌，并对其基因组进行分型，以评估多位点序列类型（STs）、毒力和耐药性。结果717份样品中检出弧菌23株（3.2%），其中7个农场检出空肠弯曲菌16株，2个农场检出大肠弯曲菌7株。羊驼检出率（4.9%,21/427）高于大羊驼（0.7%,2/288），夏季检出率较高。分子分型显示出较高的遗传异质性，尽管一些STs在不同时间点、动物和农场中复发，表明可能存在地方性定植。鉴定出9个不同的空肠C. STs和2个大肠C. STs，其中许多属于牲畜和人类常见的克隆复合体（CCs）。所有分离株都携带与运动性、粘附性、侵袭性和毒素产生相关的毒力基因，而来自CC21的一些分离株携带与格林-巴罗综合征相关的基因。抗生素敏感性试验显示红霉素、庆大霉素和氯霉素为野生型表型。在3株分离株中发现环丙沙星耐药，gyrA中存在T86I突变；一株空肠梭菌携带tet(O)，具有四环素抗性。结论sacs携带的弯曲杆菌与人畜谱系有关，具有与人畜共患传播相关的毒力和耐药性状。它们在德国农场的出现凸显了在“同一个健康”框架下有针对性的监测和生物安全的必要性。

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引用次数: 0

One Health antimicrobial resistance modelling: from science to policy One Health抗菌素耐药性建模：从科学到政策。

Science in One Health

Pub Date : 2026-01-01 DOI: 10.1016/j.soh.2026.100146

Carys J. Redman-White , Gwen Knight , Cristina Lanzas , Rodolphe Mader , Bram van Bunnik , Fernando O. Mardones , Adrian Muwonge , Guillaume Lhermie , Andrew R. Peters , Dominic Moran

Modern human and veterinary medical interventions to combat infectious diseases depend on the continued efficacy of antimicrobial drugs. Antimicrobial resistance (AMR) is the quintessential One Health challenge threatening human and animal health and welfare and has environmental effects on ecological communities in soil and water. Policy guidance on AMR needs to anticipate the likely outcomes of different interventions and courses of action. For that, transdisciplinary collaboration to understand the development, spread, and impacts of AMR is crucial. We report the outcomes of an international workshop that explored the challenges and opportunities for modelling AMR across One Health settings. They include the disparity of data quality and availability, the broader knowledge gaps in key areas such as the relationship between antimicrobial use (AMU) and AMR, and the difficulty of defining AMR as a single outcome given its heterogeneity. Differences between microbial species, resistance genes, environments (i.e., terrestrial vs. aquatic) and practical settings (e.g., human clinical vs. veterinary, or individual vs. population) complicate the generalizability of model applications. However, synoptic AMR metrics are necessary to cut through the complexity for policymaking. We discuss the status of AMR modelling with respect to a hierarchy of modelling evidence for decision-making. Finally, we consider learnings from modelling other wicked environmental challenges to develop a pragmatic approach to inform policy.

现代人类和兽医防治传染病的干预措施依赖于抗微生物药物的持续功效。抗菌素耐药性（AMR）是威胁人类和动物健康和福利的典型健康挑战，并对土壤和水的生态群落产生环境影响。关于抗微生物药物耐药性的政策指导需要预测不同干预措施和行动方针可能产生的结果。为此，跨学科合作以了解抗菌素耐药性的发展、传播和影响至关重要。我们报告了一个国际研讨会的结果，该研讨会探讨了在单一健康环境中模拟抗菌素耐药性的挑战和机遇。它们包括数据质量和可用性的差异，在关键领域（如抗菌素使用（AMU）和抗菌素耐药性之间的关系）存在更广泛的知识差距，以及由于抗菌素耐药性的异质性，难以将其定义为单一结果。微生物种类、耐药基因、环境（如陆生vs水生）和实际环境（如人类临床vs兽医，或个体vs群体）之间的差异使模型应用的普遍性复杂化。然而，概括性的AMR指标是必要的，以减少政策制定的复杂性。我们讨论了相对于决策的建模证据层次的AMR建模的地位。最后，我们考虑从其他恶劣环境挑战的建模中学习，以制定一种实用的方法来为政策提供信息。

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引用次数: 0

Navigating the challenges in implementing financial incentives for behavior change at the intersection of human, animal, and ecosystem health: a case study 在人类、动物和生态系统健康的交叉点实施行为改变财政激励的挑战：一个案例研究

Science in One Health

Pub Date : 2026-01-01 DOI: 10.1016/j.soh.2025.100144

John M. Kerr , Maryann G. Delea , Minwoong Chung , Jinhua Zhao , Jesse Crawford , Maria Knight Lapinski

With the global expansion of financial incentives to promote behavior change, they are being considered in One Health contexts characterized by the interdependence of human, animal, and ecosystem health. Little specific evidence exists about how to maximize the effectiveness of financial incentives and minimize negative outcomes in these complex settings. We review over two decades of research on financial incentives for behavior change to examine their potential effects on improved practices related to water, sanitation and hygiene, food safety, and animal and ecosystem health. We apply lessons from the literature to the case of Guinea worm disease, a neglected tropical disease for which financial incentives have been utilized or considered to motivate the uptake of various preventive behaviors. Guinea worm disease prevention is a useful example for considering the advantages, disadvantages, and unknowns of incorporating financial incentives into behavior change interventions because such an approach calls for changes in multiple behaviors with diverse attributes, and the use of incentives may have implications for other disease control, elimination, and eradication programs. Further, Guinea worm disease represents a classic One Health challenge with interventions necessary in human, animal, and ecological systems to reduce disease incidence. We present evidence-based recommendations for the design and use of incentives that may further facilitate effective behavior change. We also discuss potential negative outcomes from incentives, and critical unknowns such as how to design incentives for collective behavior and what happens when incentives end. We stress that financial incentives are not always appropriate; they must be considered carefully and coupled with proper communication efforts that are driven by a deep understanding of community social norms, motivations, and practices.

随着促进行为改变的财政激励在全球范围内的扩大，它们正在以人类、动物和生态系统健康相互依存为特征的“同一个健康”背景下被考虑。关于如何在这些复杂的环境中最大化财政激励的有效性并最小化负面结果，几乎没有具体的证据存在。我们回顾了二十多年来关于行为改变的财政激励的研究，以检查其对改善与水、环境卫生和个人卫生、食品安全以及动物和生态系统健康有关的做法的潜在影响。我们将文献中的经验教训应用于麦地那龙线虫病的病例，这是一种被忽视的热带病，财政激励已被利用或被认为是为了激励采取各种预防行为。麦地那龙线虫病的预防是一个有用的例子，可以考虑将财政激励纳入行为改变干预措施的优点、缺点和未知因素，因为这种方法需要改变具有不同属性的多种行为，并且激励的使用可能对其他疾病控制、消除和根除计划有影响。此外，麦地那龙线虫病是典型的“同一个健康”挑战，需要在人类、动物和生态系统中采取必要的干预措施，以减少疾病发病率。我们提出了基于证据的建议，以设计和使用激励措施，进一步促进有效的行为改变。我们还讨论了激励的潜在负面结果，以及关键的未知因素，如如何设计集体行为的激励，以及激励结束时会发生什么。我们强调，财政激励并不总是适当的；必须仔细考虑这些问题，并结合对社区社会规范、动机和实践的深刻理解所驱动的适当沟通努力。

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引用次数: 0

Assessing risk perception and knowledge gaps of tick-borne diseases in Nei Mongol Zizhiqu and Northeast China 内蒙古自治区及东北地区蜱传疾病风险认知及知识缺口评估

Science in One Health

Pub Date : 2026-01-01 DOI: 10.1016/j.soh.2026.100149

Tingting Wang , Sen Li

Background

Ticks are key vectors of zoonotic diseases in the Northern Hemisphere, including China, yet surveillance and public awareness remain limited. While global studies address risk perception, similar research in China, especially with spatial or longitudinal detail, is scarce. This study assesses tick-borne disease risk perception, influencing factors, and spatial variation in Northeast China and Nei Mongol Zizhiqu (also known as Inner Mongolia Autonomous Region) to inform targeted interventions.

Methods

In 2019, a cross-sectional questionnaire surveyed 4000 adults in Heilongjiang, Jilin, Liaoning, and Nei Mongol Zizhiqu using multi-stage sampling. Knowledge was assessed in four domains: tick biology/ecology, bite treatment, tick-borne diseases, and bite prevention, alongside socio-demographic and behavioral data. Descriptive statistics and multiple logistic regression identified knowledge levels and associated factors.

Results

Knowledge of tick biology was relatively high (1830/4000, 45.8% with high knowledge), but awareness of bite treatment, diseases, and especially prevention was low (31.5% with high tick-borne disease knowledge; 21.6% with high prevention knowledge), even among high-risk groups. Urban residents had higher knowledge than those in rural or remote areas. Frequent woodland visits and prior tick bites increased knowledge of tick biology (regression coefficients: 0.311 and 0.387, both P < 0.001) but not prevention. Education and outdoor activity showed mixed associations with knowledge domains.

Conclusion

Major gaps exist in public knowledge of tick-borne diseases, particularly regarding prevention, with notable disparities across regions and risk groups. Targeted, region-specific interventions are urgently needed to improve awareness and protection, especially in high-risk and low-awareness areas.

蜱是包括中国在内的北半球人畜共患疾病的主要媒介，但监测和公众意识仍然有限。虽然全球研究关注风险认知，但中国的类似研究，特别是空间或纵向细节的研究，很少。本研究旨在评估中国东北和内蒙古自治区蜱传疾病的风险认知、影响因素和空间变异，为有针对性的干预提供依据。方法2019年采用横断面问卷法，对黑龙江、吉林、辽宁、内蒙古、紫治区的4000名成人进行多阶段抽样调查。知识评估在四个领域：蜱生物学/生态学，咬伤治疗，蜱传疾病和咬伤预防，以及社会人口和行为数据。描述性统计和多元逻辑回归确定了知识水平和相关因素。结果蜱生物学知识知知率较高（1830/4000,45.8%知知率高），但对咬伤治疗、疾病特别是预防的知知率较低（31.5%知知率高，21.6%知知率高），高危人群也是如此。城市居民的知识水平高于农村和偏远地区的居民。频繁的林地访问和之前的蜱叮咬增加了蜱生物学的知识（回归系数：0.311和0.387,P < 0.001），但没有预防作用。教育和户外活动显示出与知识领域的混合关联。结论公众对蜱传疾病的认知存在较大差距，特别是对蜱传疾病预防的认知存在较大差距，不同地区和危险人群之间存在显著差异。迫切需要有针对性的、针对特定区域的干预措施，以提高认识和保护，特别是在高风险和低认识地区。

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引用次数: 0

Tick threats in the context of climate change: One Health response strategies in the Middle East and North Africa region 气候变化背景下的蜱虫威胁：中东和北非区域的一种卫生应对战略

Science in One Health

Pub Date : 2026-01-01 DOI: 10.1016/j.soh.2026.100148

Nighat Perveen , Olivier Sparagano , Mohamed Gharbi , Gulfaraz Khan , Moneeb Qablan , Daniil Iliashevich , Uday Kishore , Arve Lee Willingham

The Middle East and North Africa (MENA) region faces considerable challenges from ticks and tick-borne diseases (TBDs), exacerbated by climate change and its impact on human and animal health, as well as overall productivity. To address these interconnected issues, the United Arab Emirates University, located in Al Ain, Abu Dhabi Emirate, United Arab Emirates (UAE), hosted a multinational, transdisciplinary One Health symposium on climate change, ticks, and tick-borne diseases. The event brought together experts from across the region and beyond, featuring seven invited speakers who explored a wide range of topics, including climate change, TBDs of humans and animals, tick research in the UAE, and the One Health approach. The symposium highlighted major knowledge and research gaps, particularly in underexplored areas such as acaricide resistance, tick vaccine development, tick–pathogen interactions, wildlife–livestock interfaces, and the circulation and movement of tick-borne pathogens across the region. Discussions underscored the heavy burden of ticks and TBDs in the MENA region and their complex economic and public health implications. Participants emphasized the need for regional collaboration, enhanced tick surveillance, pathogen detection, and integrated management strategies. The symposium also encouraged the establishment of future alliances and partnerships among universities, government departments, and research institutions to foster joint research projects, resource sharing, and knowledge exchange. Within the One Health paradigm, participants concluded that regional priorities should focus on identifying and understanding tick-related problems, strengthening cross-sectoral cooperation, utilizing regional expertise and infrastructure, and engaging all stakeholders including the public in sustainable tick and TBD management. This collaborative approach is essential to mitigate the multifaceted challenges posed by ticks, tick-borne pathogens, and a changing climate in the MENA region.

中东和北非（MENA）地区面临着来自蜱虫和蜱媒疾病（tbd）的巨大挑战，气候变化及其对人类和动物健康以及整体生产力的影响加剧了这一挑战。为了解决这些相互关联的问题，位于阿拉伯联合酋长国（UAE）阿布扎比酋长国Al Ain的阿拉伯联合酋长国大学主办了一次关于气候变化、蜱虫和蜱媒疾病的多国、跨学科“同一个健康”研讨会。该活动汇集了来自该地区及其他地区的专家，邀请了7位演讲者，他们探讨了广泛的主题，包括气候变化、人类和动物的tbd、阿联酋的蜱虫研究和“同一个健康”方法。研讨会强调了主要的知识和研究差距，特别是在未充分开发的领域，如杀螨剂耐药性、蜱疫苗开发、蜱-病原体相互作用、野生动物-牲畜界面以及蜱传病原体在整个区域的传播和移动。讨论强调了中东和北非地区蜱虫和TBDs的沉重负担及其复杂的经济和公共卫生影响。与会者强调需要开展区域合作，加强蜱虫监测、病原体检测和综合管理战略。研讨会亦鼓励大学、政府部门和研究机构在未来建立联盟和伙伴关系，以促进联合研究项目、资源共享和知识交流。在同一个健康模式下，与会者得出结论，区域优先事项应侧重于确定和了解与蜱虫有关的问题，加强跨部门合作，利用区域专门知识和基础设施，并使包括公众在内的所有利益攸关方参与可持续的蜱虫和TBD管理。这种合作方法对于缓解蜱虫、蜱传病原体和中东和北非地区气候变化带来的多方面挑战至关重要。

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引用次数: 0

The 2024 WHO bacterial priority pathogens list: a critical evolution from a global One Health perspective 2024年世卫组织细菌重点病原体清单：从全球“同一个健康”的角度来看的重要演变

Science in One Health

Pub Date : 2026-01-01 DOI: 10.1016/j.soh.2025.100145

Subhankar Mukhopadhyay , Ye Peng , Hein Min Tun

The 2024 WHO Bacterial Priority Pathogens List (WHO BPPL) is a critical tool for refining global antimicrobial resistance (AMR) strategy, prioritizing 24 bacteria with a focus on Gram-negatives and community threats like Salmonella Typhi. This perspective examines its One Health implications. While the 2024 WHO BPPL effectively guides research and development (R&D), policy, and infection control through vaccines and water, sanitation and hygiene (WASH) programs, its human-centric approach underrepresents critical agricultural and environmental AMR drivers. Surveillance biases towards high-income countries and the inherent challenges of cross-sectoral monitoring—given the distinct niches of pathogens like Enterococcus faecium and Shigella—further limit its scope. We call for integrating zoonotic and environmental metrics, strengthening global surveillance (e.g., Global Antimicrobial Resistance and Use Surveillance System [GLASS]), and accelerating development of novel therapies to advance a more equitable and holistic AMR response.

2024年世卫组织细菌重点病原体清单（世卫组织BPPL）是完善全球抗菌素耐药性（AMR）战略的重要工具，对24种细菌进行了优先排序，重点关注革兰氏阴性菌和伤寒沙门氏菌等社区威胁。这一观点考察了其“同一个健康”的含义。虽然2024年世卫组织基本方案清单通过疫苗和水、环境卫生和个人卫生（WASH）规划有效地指导了研发、政策和感染控制，但其以人为本的方法未能充分代表抗生素耐药性的关键农业和环境驱动因素。鉴于粪肠球菌和志贺氏菌等病原体的独特生态位，监测偏向于高收入国家以及跨部门监测的固有挑战进一步限制了其范围。我们呼吁整合人畜共患病和环境指标，加强全球监测（例如，全球抗菌素耐药性和使用监测系统[GLASS]），并加快新疗法的开发，以促进更公平和全面的抗菌素耐药性应对。

引用次数: 0

Emerging zoonotic risk: molecular detection of Trichobilharzia franki in Western Europe's largest artificial lake, Alqueva, Portugal 新出现的人畜共患风险：在西欧最大的人工湖，葡萄牙Alqueva，弗兰基毛叉菌的分子检测。

Science in One Health

Pub Date : 2026-01-01 DOI: 10.1016/j.soh.2025.100143

Maria Teresa Bispo, Isabel Larguinho Maurício, Pedro Manuel Ferreira, Silvana Belo, Manuela Calado

Background

Emerging parasites pose increasing challenges at the interface of human, animal, and ecosystem health. Among these, Trichobilharzia spp., schistosomatid of migratory and resident waterfowl, can cause cercarial dermatitis (CD) when its larval stage (cercaria) accidentally penetrate human skin. While this parasite has been documented in several European countries, its presence in Portugal has remained unreported, leaving a critical gap in understanding potential zoonotic risks in local freshwater ecosystems. Therefore, this study aimed to investigate the presence of Trichobilharzia spp. in freshwater snails from Lake Alqueva, providing the first insights into its potential ecological and public health implications in Portugal.

Methods

Fieldwork was carried out on Lake Alqueva, considered the largest artificial reservoir in Western Europe, with ecological and public health relevance. Freshwater snails from shore locations in Lake Alqueva were examined for cercarial shedding, and molecular identification was performed by PCR amplification of the cytochrome c oxidase subunit 1 (COX1) gene and internal transcribed spacer (ITS) regions.

Results

Morphological and genetic analyses confirmed Trichobilharzia franki from Radix auricularia, showing high homology with European and Asian lineages. Moreover, human infections compatible with CD were also reported in the region.

Conclusions

These findings highlight the need for continued malacological surveillance, particularly in recreational freshwater bodies, to assess risk areas and implement mitigation strategies. Furthermore, this study expands the known geographical distribution of T. franki in Europe and underscores the importance of integrating ecological and public health approaches to monitor emerging zoonotic parasites.

背景：新出现的寄生虫对人类、动物和生态系统健康构成越来越大的挑战。其中，迁徙和滞留水禽的血吸虫Trichobilharzia spp.，当其幼虫期（尾蚴）不小心穿透人体皮肤时，可引起子宫颈皮炎（CD）。虽然这种寄生虫在几个欧洲国家都有记录，但在葡萄牙仍未报告，这在了解当地淡水生态系统中潜在的人畜共患风险方面留下了重大空白。因此，本研究旨在调查Alqueva湖淡水蜗牛中Trichobilharzia spp.的存在，为其在葡萄牙潜在的生态和公共卫生影响提供首次见解。方法：在Alqueva湖进行实地调查，该湖被认为是西欧最大的人工水库，具有生态和公共卫生相关性。研究了Alqueva湖沿岸淡水蜗牛的尾蚴脱落情况，并通过PCR扩增细胞色素c氧化酶亚基1 （COX1）基因和内部转录间隔区（ITS）进行了分子鉴定。结果：形态学和遗传分析均证实来自木耳的franki毛叉菌与欧洲和亚洲血统具有较高的同源性。此外，该区域还报告了与乳糜泻相容的人感染。结论：这些发现突出了持续进行线虫学监测的必要性，特别是在休闲淡水水体中，以评估风险区域并实施缓解战略。此外，这项研究扩大了已知的法兰氏弓形虫在欧洲的地理分布，并强调了将生态和公共卫生方法结合起来监测新出现的人畜共患寄生虫的重要性。

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引用次数: 0

One Health showcase from Asia: the Lawa model—a community-based approach to liver fluke control in Thailand 一个来自亚洲的健康展示：Lawa模式——泰国以社区为基础的肝吸虫控制方法

Science in One Health

Pub Date : 2025-01-01 DOI: 10.1016/j.soh.2025.100108

Banchob Sripa , Sirikachorn Tangkawattana

Liver fluke infection caused by Opisthorchis viverrini is a significant public health challenge in the Lower Mekong Basin, affecting over 10 million people and leading to cholangiocarcinoma, a fatal bile duct cancer. Traditional control efforts often fail due to complex socio-cultural and ecological factors. The Lawa model, implemented in the Lawa Lake region of Khon Kaen, Thailand, adopts a One Health framework to integrate human health interventions, environmental modifications, and animal reservoir management, addressing the transmission cycle comprehensively. This approach respects the cultural context of Isan communities and leverages evidence-based, community-driven strategies. Over 15 years, the model has achieved remarkable success, reducing human infection rates from 60 % to below 5 % and eliminating infections in intermediate hosts. Key lessons include the importance of systems thinking, transdisciplinary collaboration, and community engagement in achieving sustainable health outcomes, despite challenges like cultural dietary practices and environmental disruptions such as flooding.

由 Opisthorchis viverrini 引起的肝吸虫感染是湄公河下游流域面临的一项重大公共卫生挑战，影响到 1,000 多万人，并导致胆管癌（一种致命的胆管癌）。由于复杂的社会文化和生态因素，传统的防治工作往往以失败告终。在泰国孔敬省拉瓦湖地区实施的 "拉瓦模式 "采用 "一个健康 "框架，将人类健康干预、环境改造和动物水库管理结合起来，全面解决传播循环问题。这种方法尊重伊桑社区的文化背景，并利用以证据为基础的社区驱动战略。15 年来，该模式取得了显著成功，将人类感染率从 60% 降至 5% 以下，并消除了中间宿主的感染。主要经验包括：尽管存在文化饮食习惯和洪水等环境干扰等挑战，但系统思考、跨学科合作和社区参与在实现可持续健康成果方面的重要性。

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引用次数: 0

One Health and planetary health research landscapes in the Arab world “同一个健康”和阿拉伯世界的全球健康研究景观

Science in One Health

Pub Date : 2025-01-01 DOI: 10.1016/j.soh.2025.100105

Shaher Zyoud , Sa'ed H. Zyoud

This review explored research trends in One Health and planetary health in the Arab world, a region confronting major sustainability challenges. These fields are crucial in combating global pressing concerns like infectious diseases, biodiversity loss, antimicrobial resistance, climate change, and air pollution. The COVID-19 pandemic stressed their significance to global health and sustainable development. This analysis assessed the Arab world's contributions to these concepts applying performance analysis and visualization mapping, revealing that One Health outperformed planetary health in terms of productivity and number of contributed countries. Egypt, Saudi Arabia, and the United Arab Emirates have emerged as leading contributors to One Health and planetary health research in the Arab world. Meanwhile, the United States and the United Kingdom, as non-Arab nations, play a pivotal role in fostering collaborative efforts with the region. The trajectory of One Health research has indeed shown remarkable exponential growth, especially since the beginning of the COVID-19 pandemic in 2019, which is an indication of increasing relevance in the address of global health challenges. Conversely, planetary health presents an irregular growth pattern, with a strong point in the development of this area standing out in 2023. The unique set of social, cultural, governance, and agricultural attributes of the Arab region are joined by major environmental challenges that define the focus of both One Health and planetary health research efforts. Climate change, environmental contexts, and public health feature prominently in both One Health and planetary health, with One Health focusing mainly on infectious diseases and planetary health addressing the implications of climate change on human health. Advancing these concepts demands the establishment of a regional governing body to oversee an integrated One Health and planetary health strategy, foster regional research communities and alliances, secure political will and funding, and ensure the integration of these concepts into policy and academic frameworks.

本综述探讨了面临重大可持续性挑战的阿拉伯世界“同一个健康”和“地球健康”的研究趋势。这些领域对于应对传染病、生物多样性丧失、抗菌素耐药性、气候变化和空气污染等全球紧迫问题至关重要。2019冠状病毒病大流行强调了它们对全球卫生和可持续发展的重要性。这一分析利用绩效分析和可视化制图评估了阿拉伯世界对这些概念的贡献，结果显示，在生产力和贡献国数量方面，“同一个健康”的表现优于地球健康。埃及、沙特阿拉伯和阿拉伯联合酋长国已成为阿拉伯世界“同一个健康”和全球健康研究的主要贡献者。与此同时，美国和英国作为非阿拉伯国家，在促进与该地区的合作努力方面发挥着关键作用。“同一个健康”的研究轨迹确实呈现出显著的指数级增长，特别是自2019年COVID-19大流行开始以来，这表明该项目在应对全球卫生挑战方面的相关性日益增强。相反，行星健康呈现出不规则的增长模式，在2023年这一领域的发展有一个亮点。除了阿拉伯地区独特的社会、文化、治理和农业属性外，还面临着重大的环境挑战，这些挑战确定了“同一个健康”和“地球健康”研究工作的重点。气候变化、环境背景和公共卫生在“同一个健康”和“地球健康”中都具有突出特点，“同一个健康”主要侧重于传染病和地球健康，处理气候变化对人类健康的影响。推进这些概念需要建立一个区域理事机构，以监督“同一个健康”和“地球健康”综合战略，促进区域研究社区和联盟，确保政治意愿和资金，并确保将这些概念纳入政策和学术框架。

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引用次数: 0

A One Health call to re examine medical practice: going beyond strong anthropocentrism 同一个健康呼吁重新审视医疗实践：超越强烈的人类中心主义

Science in One Health

Pub Date : 2025-01-01 DOI: 10.1016/j.soh.2025.100129

Moshe Porat Wojakowski , Shir Porat-Butman

One Health discourse rightly stresses human–animal–environment interdependence, yet its normative footing can be thin and often defaults to strong anthropocentrism, valuing non-human beings and ecosystems only instrumentally. This perspective focuses on clinical decision-making and proposes a shift from strong anthropocentrism to weak anthropocentrism. weak anthropocentrism maintains the human-centered mandate that underpins medicine and public health while at the same time requiring proportionality, least harm, and intergenerational responsibility that acknowledge intrinsic—not merely instrumental—value in ecological systems and non-human life. Building on One Health's systems thinking, the framework offers a pragmatic approach rather than a radical turn to biocentrism or ecocentrism, and it recognizes ongoing debates about prudential versus radical interpretations within One Health. We illustrate feasibility with green oncology, where clinically equivalent options are selected to reduce life-cycle emissions, waste, and antimicrobial pressures—showing how ecological considerations can be integrated without compromising patient or population outcomes. The proposal aligns with contemporary regulatory strategies that recommend a One Health lens and invites a practical recalibration of public health policy: expand evaluative criteria, embed ecological reasoning in decision processes, and align clinical benefit with long-term planetary stewardship. Weak anthropocentrism thus offers a workable, ethically coherent route to extend “do no harm” beyond humans while remaining faithful to the core commitments of both clinical care and public health.

“一种健康”话语正确地强调了人-动物-环境的相互依存关系，但其规范基础可能薄弱，往往默认为强烈的人类中心主义，只重视非人类和生态系统。这一观点侧重于临床决策，并提出了从强人类中心主义到弱人类中心主义的转变。弱人类中心主义坚持以人为中心的使命，支撑着医学和公共卫生，同时要求适度、伤害最小和代际责任，承认生态系统和非人类生命的内在价值——而不仅仅是工具价值。该框架以One Health的系统思维为基础，提供了一种务实的方法，而不是激进地转向生物中心主义或生态中心主义，它承认在One Health内部正在进行的关于审慎与激进解释的辩论。我们说明了绿色肿瘤学的可行性，选择临床等效的选择来减少生命周期的排放、浪费和抗微生物压力，展示了如何在不损害患者或人群结果的情况下整合生态考虑。该提案与推荐“一个健康”镜头的当代监管战略保持一致，并邀请对公共卫生政策进行实际的重新校准：扩大评估标准，在决策过程中嵌入生态推理，并将临床效益与长期的地球管理相结合。因此，弱人类中心主义提供了一条可行的、道德上连贯的路线，将“不伤害”延伸到人类之外，同时忠实于临床护理和公共卫生的核心承诺。

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