Science in One Health最新文献_第2页

Global, regional, and national temporal trend and patterns of change in the burden of leishmaniasis from 1990 to 2021: an analysis of the Global Burden of Disease Study 2021 1990年至2021年利什曼病负担的全球、区域和国家时间趋势和变化模式：对2021年全球疾病负担研究的分析

Science in One Health

Pub Date : 2025-01-01 DOI: 10.1016/j.soh.2025.100123

Shunxian Zhang , Guobing Yang , Shan Lv , Lei Duan , Muxin Chen , Qin Liu , Liguang Tian , Shizhu Li , Jinxin Zheng

Background

Leishmaniasis is a globally prevalent parasitic disease caused by protozoa of the genus Leishmania. This study utilizes Global Burden of Disease Study 2021 (GBD 2021) data to systematically evaluate the global, regional, and national epidemiological trends, thereby providing a scientific basis for optimizing the prevention and control strategies for leishmania infections.

Methods

Data from the GBD 2021 database were analyzed to evaluate trends in age-standardized incidence rate (ASIR), age-standardized prevalence rate (ASPR), age-standardized mortality rate (ASMR), and age-standardized disability-adjusted life-years rate (ASDR) for leishmaniasis across global, regional, and national levels, stratified by age, sex, and sociodemographic index (SDI). A Bayesian age-period-cohort (BAPC) model was employed to project future burden. Analyses included the slope index of inequality and the concentration index to assess health disparities, frontier analysis to estimate achievable outcomes based on development levels, and decomposition analysis to identify the drivers of changes in DALYs number.

Results

From 1990 to 2021, the ASIR of leishmaniasis decreased from 17.82 to 14.34 per 100,000 population, while the ASPR increased from 62.94 to 76.96 per 100,000 population. Most strikingly, the ASMR showed a dramatic reduction from 1.05 to 0.07 per 100,000 population. However, concerning increases were observed in absolute case numbers, with incident cases rising from 1.01 to 1.10 million and prevalent cases nearly doubling from 3.18 to 6.21 million. Notably, Syria exhibited the most severe deterioration in ASDR (average annual percentage change [AAPC] = 4.78 %, 95 % confidence interval [CI]: 4.67–4.89). Frontier analysis identified several high-burden countries including South Sudan, the Syrian Arab Republic, Afghanistan, Suriname, and Sudan as persistent hotspots requiring targeted interventions. A robust inverse correlation was observed between all disease metrics (ASIR, ASPR, ASMR, ASDR, and case counts) and the SDI, with all associations demonstrating high statistical significance (P < 0.001).

Conclusions

Leishmaniasis continues to pose significant public health challenges in Southeast Asia, North Africa, and Middle East. Strengthening public health interventions, optimizing resource distribution, and focusing on health governance in low- and middle-income countries are key to addressing the ongoing burden. One Health-based integrated strategies, particularly in vector control, host management, and environmental sanitation, are essential for reducing the disease burden and achieving long-term control.

背景：利什曼病是由利什曼原虫引起的一种全球流行的寄生虫病。本研究利用全球疾病负担研究2021 （GBD 2021）数据，系统评估全球、区域和国家流行病学趋势，为优化利什曼原虫感染防控策略提供科学依据。方法分析来自GBD 2021数据库的数据，以评估全球、地区和国家各级利什曼病的年龄标准化发病率（ASIR）、年龄标准化患病率（ASPR）、年龄标准化死亡率（ASMR）和年龄标准化残疾调整生命年率（ASDR）的趋势，并按年龄、性别和社会人口指数（SDI）分层。采用贝叶斯年龄-时期-队列（BAPC）模型预测未来负担。分析包括评估健康差距的不平等斜率指数和集中指数，根据发展水平估计可实现的结果的前沿分析，以及确定DALYs数量变化驱动因素的分解分析。结果1990 - 2021年，利什曼病ASIR由17.82 / 10万人下降至14.34 / 10万人，而ASPR由62.94 / 10万人上升至76.96 / 10万人。最引人注目的是，ASMR显示了从每10万人1.05人到0.07人的急剧下降。然而，绝对病例数却出现了令人担忧的增长，发病病例从101万例增加到110万例，流行病例从318万例增加到621万例，几乎翻了一番。值得注意的是，叙利亚的ASDR恶化最为严重（年均百分比变化[AAPC] = 4.78%， 95%置信区间[CI]: 4.67-4.89）。前沿分析确定了几个高负担国家，包括南苏丹、阿拉伯叙利亚共和国、阿富汗、苏里南和苏丹，它们是需要有针对性干预的持续热点。观察到所有疾病指标（ASIR、ASPR、ASMR、ASDR和病例数）与SDI之间存在显著的负相关，且所有相关性均具有高度统计学意义（P < 0.001）。结论利什曼病在东南亚、北非和中东地区继续构成重大公共卫生挑战。加强公共卫生干预措施、优化资源分配以及注重低收入和中等收入国家的卫生治理是解决当前负担的关键。以健康为基础的综合战略，特别是在病媒控制、宿主管理和环境卫生方面，对于减轻疾病负担和实现长期控制至关重要。

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引用次数: 0

Modeling the distribution of the invasive snail Physella acuta in China: Implications for ecological and economic impact 入侵蜗牛尖藻（Physella acuta）在中国的分布及其生态和经济影响

Science in One Health

Pub Date : 2025-01-01 DOI: 10.1016/j.soh.2025.100107

Yingxuan Yin , Anyuan Xu , Xiaowen Pan , Qing He , Aoxun Wu , Linya Huang , Yinjuan Wu , Xuerong Li

Background

The invasive freshwater snail Physella acuta poses significant threats to the ecological environment, public health safety, and the agricultural and forestry economy. Gaining insight into their geographical spread in China under current and future climate scenarios is crucial for effective monitoring and control strategies against this invasive species.

Methods

Global distribution data of P. acuta were collected and screened using “ENMtool”; environmental variables were screened based on contribution of environmental variables, jackknife test and variable correlation analysis using MaxEnt 3.4.1 and GraphPad Prism 8; “kuenm” package in R 4.0.4 software was used to calculate and adjust model parameters; the optimized MaxEnt model was used to predict the potential distribution range of P. acuta in China under different climate scenarios; ArcGIS 10.7 was used to process and visualize the results.

Results

A total of 2012 P. acuta distribution points were screened, and the warmest quarter, mean temperature of the coldest season, precipitation in March and November were used to construct the MaxEnt model with an area under the curve (AUC) value of 0.918. According to the prediction, P. acuta is currently widely spread across the Guangxi Zhuang Autonomous Region, Guizhou Province, Yunnan Province, Chongqing Municipality, and areas proximate to the Yangtze River Basin in the middle-lower Yangtze Plain, which encompass 10.22 % of China's terrestrial area. Under future climate projections, the suitable habitats for P. acuta in southern regions are expected to contract, whereas those in northern regions are anticipated to remain relatively stable. As a result, the overall distribution center is likely to shift marginally northward.

Conclusion

With the future climate change, the total suitable habitats of P. acuta in China showed a shrinking trend, and the shrinkage was more significant in the southern low-latitude suitable habitats. To mitigate its impact on China's ecosystem and the loss caused by P. acuta invasion, relevant departments should increase monitoring and prompt control, and implement efficient preventive and eradication measures.

背景入侵淡水蜗牛尖螺（Physella acuta）对生态环境、公共卫生安全和农林经济构成重大威胁。了解其在当前和未来气候情景下在中国的地理分布对有效监测和控制该入侵物种至关重要。方法采用“ENMtool”软件收集和筛选全球尖尖尖沙鼠分布资料；采用MaxEnt 3.4.1软件和GraphPad Prism 8软件进行环境变量贡献、折刀检验和变量相关分析，筛选环境变量；采用r4.0.4软件中的“kuenm”包对模型参数进行计算和调整；利用优化后的MaxEnt模型预测了不同气候情景下中国尖尖叶茅的潜在分布范围；使用ArcGIS 10.7对结果进行处理和可视化。结果共筛选了2012个尖尖沙鼠分布点，利用最暖季、最冷季平均气温、3月和11月降水量构建了MaxEnt模型，曲线下面积（AUC）值为0.918。预测结果表明，目前，该植物主要分布在广西壮族自治区、贵州省、云南省、重庆市以及长江中下游平原的长江流域附近地区，占中国陆地面积的10.22%。在未来的气候预测下，南方地区的适宜生境将会缩小，而北方地区的适宜生境将保持相对稳定。因此，整个配送中心可能会略微向北转移。结论随着未来气候的变化，中国尖尖胡杨的适宜生境总体呈缩小趋势，其中南部低纬度适宜生境的缩小更为明显。为减轻其对中国生态系统的影响，减轻其入侵造成的损失，有关部门应加强监测和及时控制，并采取有效的预防和根除措施。

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引用次数: 0

Incorporating oral health into the One Health agenda: contributions and implications 将口腔健康纳入“同一个健康”议程：贡献和影响

Science in One Health

Pub Date : 2025-01-01 DOI: 10.1016/j.soh.2025.100111

Lara G. Moussa , Omer Faruk Sonmez , Raman Bedi

The One Health (OH) approach emphasises the relationship between human, animal, and environmental health, underscoring the necessity of cross-sectoral collaboration to address global health challenges. This paper explores the integration of oral health within the OH framework, mainly focusing on its relationship to antimicrobial resistance, zoonotic and vector-borne diseases, and climate change. Furthermore, this paper highlights how dental practices impact environmental sustainability and discusses the role of sustainable dentistry in reducing plastic waste, managing mercury disposal, and minimising pesticide exposure. Lastly, the paper offers actionable recommendations to support oral health professionals in adopting environmentally friendly practices, ultimately promoting a comprehensive OH approach to improve population health and resilience against future health threats.

“同一个健康”方针强调人类、动物和环境卫生之间的关系，强调跨部门合作应对全球卫生挑战的必要性。本文探讨了口腔健康在OH框架内的整合，主要关注其与抗菌素耐药性、人畜共患病和媒介传播疾病以及气候变化的关系。此外，本文强调了牙科实践如何影响环境可持续性，并讨论了可持续牙科在减少塑料废物，管理汞处置和尽量减少农药暴露方面的作用。最后，本文提供了可操作的建议，以支持口腔卫生专业人员采用环境友好的做法，最终促进全面的口腔卫生方法，以改善人口健康和抵御未来健康威胁的能力。

引用次数: 0

Air pollution might contribute to antimicrobial resistance: a One Health perspective 空气污染可能有助于抗菌素耐药性：同一个健康的观点

Science in One Health

Pub Date : 2025-01-01 DOI: 10.1016/j.soh.2025.100118

Leshan Xiu , Shuangqing Hu

Air pollution and antimicrobial resistance (AMR) are two critical challenges that threaten global health and sustainability. Emerging research suggests a significant connection between these phenomena, with air pollution potentially acting as a driver for the development, dissemination, and persistence of antimicrobial resistance genes (ARGs). Drawing on evidence from recent studies, we highlight the mechanisms through which air pollution contributes to AMR, including the role of particulate matter, atmospheric transport, and co-selection pressure. We advocate for a comprehensive One Health approach to address the intertwined threats of air pollution and AMR, emphasizing the need for integrated policies, surveillance, and interdisciplinary research.

空气污染和抗菌素耐药性（AMR）是威胁全球健康和可持续性的两大关键挑战。新兴研究表明，这些现象之间存在重要联系，空气污染可能是抗微生物药物耐药性基因（ARGs）发展、传播和持续存在的驱动因素。根据最近研究的证据，我们强调了空气污染导致抗菌素耐药性的机制，包括颗粒物、大气运输和共同选择压力的作用。我们提倡采用一种全面的“同一个健康”方法来解决空气污染和抗生素耐药性交织在一起的威胁，强调需要采取综合政策、监测和跨学科研究。

引用次数: 0

AI tools accelerating One Health advancement: insights from the Global Public Health Week 2025 Webinar 人工智能工具加速“同一个健康”进程：来自2025年全球公共卫生周网络研讨会的见解

Science in One Health

Pub Date : 2025-01-01 DOI: 10.1016/j.soh.2025.100127

Jingshu Liu , Shenning Lu , Jiming Liu , Huaiyu Tian , Md. Tanvir Rahman , Issam Bennis , Somphou Sayasone , Daniela Polessa , Khaja Mohteshamuddin , Quanle Li , Heya Yi , Mayumi Wakimoto , Arve Lee Willingham , Raman Bedi , Xiao-Nong Zhou

This commentary emerges from a webinar titled “AI Tools Accelerating One Health Advancement for a Public Health Perspective,” held on World Health Day 2025. The event convened global experts to explore how artificial intelligence (AI) reshapes One Health initiatives. Key discussions addressed AI applications in data integration, risk assessment, and real-time public health responses. Major outcomes included strategies for incorporating AI into public health research, fostering multi-sectoral partnerships, addressing ethical and privacy concerns, and improving AI literacy. This commentary proposes six core recommendations: (1) establish robust governance frameworks; (2) develop a global AI ethics charter; (3) mandate transparency in training data and algorithms; (4) expand open-data access and AI literacy programs; (5) create interdisciplinary One Health innovation hubs; and (6) ensure AI solutions are both cutting-edge and equitable. These proposals aim to guide responsible and inclusive AI implementation to safeguard human, animal, and environmental health.

这篇评论来自于2025年世界卫生日举行的题为“人工智能工具从公共卫生角度加速健康进步”的网络研讨会。该活动召集了全球专家，探讨人工智能（AI）如何重塑“同一个健康”倡议。重点讨论了人工智能在数据整合、风险评估和实时公共卫生应对方面的应用。主要成果包括将人工智能纳入公共卫生研究、促进多部门伙伴关系、解决道德和隐私问题以及提高人工智能素养的战略。本评论提出了六个核心建议：(1)建立健全的治理框架；(2)制定全球人工智能伦理章程；(3)要求训练数据和算法透明化；(4)扩大开放数据获取和人工智能扫盲项目；(5)创建跨学科的“同一个健康”创新中心；(6)确保人工智能解决方案既前沿又公平。这些建议旨在指导负责任和包容性的人工智能实施，以保护人类、动物和环境健康。

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引用次数: 0

Integrated health surveillance and early warning systems in China under the One Health perspective: progress and challenges “一个健康”视角下的中国综合卫生监测与预警系统：进展与挑战

Science in One Health

Pub Date : 2025-01-01 DOI: 10.1016/j.soh.2025.100132

Zhichao Li , Dongliang Li , Jinwei Dong , Qixu Zhu , Youyi Zuo , Juan Pu , Lu Wang , Weipan Lei , Jun Cai , Qu Cheng , Yuzhe Li , Jing Yang , Yang Ju , Zhirui Wu

Emerging infectious diseases (EIDs), whether newly identified or re-emerging in human and animal populations, pose significant threats to global public health. China has experienced multiple EIDs outbreaks in recent years, underscoring the need for robust surveillance and early warning systems. Although China has established surveillance systems for events affecting climate, wildlife, livestock and poultry, and humans, the current systems remain inadequate for the early detection, monitoring, and prevention of zoonotic spillover events. The “One Health” approach, which integrates human, animal, and environmental health, offers a comprehensive strategy for mitigating EIDs risks. This study reviews China's national-level surveillance and early warning systems from a “One Health” perspective, highlighting key limitations and proposing future directions to enhance preparedness and response capabilities. The findings are intended to inform policy improvements and strengthen interdisciplinary collaboration for effective EIDs management.

新发传染病，无论是在人类和动物群体中新发现的还是重新出现的，都对全球公共卫生构成重大威胁。近年来，中国爆发了多起eid疫情，这凸显了建立强有力的监测和预警系统的必要性。虽然中国已经建立了影响气候、野生动物、畜禽和人类事件的监测系统，但目前的系统在早期发现、监测和预防人畜共患病溢出事件方面仍然不足。“同一个健康”办法综合了人类、动物和环境卫生，提供了一项减轻eid风险的全面战略。本研究从“一个健康”的角度回顾了中国国家级的监测和预警系统，强调了主要的局限性，并提出了加强准备和响应能力的未来方向。研究结果旨在为政策改进和加强跨学科合作提供信息，以实现有效的eid管理。

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引用次数: 0

Nipah virus outbreak trends in Bangladesh during the period 2001 to 2024: a brief review 2001年至2024年期间孟加拉国尼帕病毒暴发趋势：简要回顾

Science in One Health

Pub Date : 2025-01-01 DOI: 10.1016/j.soh.2024.100103

Awnon Bhowmik , Mahmudul Hasan , Md. Mehedi Hasan Redoy , Goutam Saha

Nipah virus (NiV) is a zoonotic threat that has caused recurrent outbreaks in Bangladesh since 2001, raising significant public health concerns. This study provides a descriptive analysis of NiV outbreaks from 2001 to 2024, examining trends in infection and death rates and their correlation with climatic factors such as temperature, humidity, and rainfall. The findings highlight significant spikes in NiV cases during specific years, with environmental factors, particularly temperature and precipitation, showing solid correlations with outbreak patterns. The study also explores the impact of population dynamics on transmission risks, including urbanization and density. By focusing on these factors, this research supports the development of targeted public health interventions in high-risk areas, particularly in Bangladesh's northwestern and central districts, where recurrent outbreaks have been observed. These insights improve surveillance and preventive strategies for mitigating future NiV outbreaks.

尼帕病毒是一种人畜共患威胁，自2001年以来在孟加拉国多次暴发，引起了重大的公共卫生关切。本研究对2001年至2024年的NiV疫情进行了描述性分析，研究了感染和死亡率的趋势及其与温度、湿度和降雨量等气候因素的相关性。研究结果强调了在特定年份NiV病例的显著高峰，环境因素，特别是温度和降水，显示出与疫情模式的牢固相关性。该研究还探讨了人口动态对传播风险的影响，包括城市化和密度。通过关注这些因素，这项研究支持在高风险地区，特别是在观察到反复暴发的孟加拉国西北部和中部地区制定有针对性的公共卫生干预措施。这些见解改善了监测和预防战略，以减轻未来的NiV疫情。

引用次数: 0

Fieldwork on animals living in extreme conditions as a source of biomedical innovation 对生活在极端条件下的动物进行实地考察，作为生物医学创新的来源。

Science in One Health

Pub Date : 2025-01-01 DOI: 10.1016/j.soh.2024.100096

Yvon Le Maho , Aurélie Tasiemski , Fabrice Bertile , Philippe Bulet

Most biomedical research on animals is based on the handful of the so-called standard model organisms, i.e. laboratory mice, rats or Drosophila, but the keys to some important biomedical questions may simply not be found in these. However, compared with the high number of molecules originating from plants in clinical use, and with the countless unique adaption mechanisms that animals have developed over the course of evolution to cope with environmental constrains, there is still few investigations on wild animals with biomedical objectives, and field studies are far fewer. A major limitation is insufficient funding, the main causes of which we analyze. We argue, however, that fieldwork is a key driver in generating new scientific knowledge as part of a One Health approach, by observing/documenting and understanding the diverse and largely unexplored biological processes evolved by animals adapted to unusual environmental conditions, which would be extreme conditions for humans. These conditions do not only refer to extreme temperatures, since lack of food or water, high pressures or lack of oxygen, are clearly extreme constraints. To conduct this research, there are serious limitations we propose to address. Specific techniques and methods are requested, not only to work in extreme environments, but also to minimize the ecological footprint of field work. The erosion of biodiversity is a major threat. The reduction of animal disturbance, a key issue, requires specific technologies and expertise. An ethical approach is requested, for the sake of transparency and to comply with the Nagoya Protocol on genetic resources. An interdisciplinary expertise and a meticulous planning are requested to overcome the field constraints and interface the associated laboratory work. We recommend focusing on the major threats to global human health today, which wild animals appear to resist particularly well, such as antibioresistance and diseases associated with lifestyle and senescence.

大多数动物生物医学研究都是基于少数所谓的标准模式生物，即实验室小鼠、大鼠或果蝇，但一些重要生物医学问题的关键可能根本不在这些生物医学研究中找到。然而，与临床应用的大量源自植物的分子相比，与动物在进化过程中发展出的无数独特的适应机制相比，以生物医学为目的的野生动物研究仍然很少，实地研究也少得多。一个主要的限制是资金不足，我们分析了其主要原因。然而，我们认为，实地考察是产生新科学知识的关键驱动因素，是“同一个健康”方法的一部分，通过观察/记录和理解动物适应不寻常环境条件（对人类来说是极端条件）而进化出的多样性和很大程度上未被探索的生物过程。这些条件不仅指极端温度，因为缺乏食物或水、高压或缺氧显然是极端的限制条件。为了进行这项研究，我们提出要解决一些严重的限制。需要特定的技术和方法，不仅要在极端环境中工作，还要尽量减少野外工作的生态足迹。生物多样性的侵蚀是一个主要威胁。减少动物干扰是一个关键问题，需要具体的技术和专门知识。为了透明度和遵守关于遗传资源的《名古屋议定书》，要求采取合乎道德的办法。需要跨学科的专业知识和细致的规划来克服现场限制并与相关的实验室工作相结合。我们建议把重点放在当今全球人类健康面临的主要威胁上，野生动物似乎特别能抵御这些威胁，例如抗生素耐药性以及与生活方式和衰老有关的疾病。

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引用次数: 0

Integration of sentinel surveillance and climate factors to accelerate malaria elimination in a changing climate of Senegal 将哨点监测和气候因素结合起来，在塞内加尔不断变化的气候中加速消除疟疾

Science in One Health

Pub Date : 2025-01-01 DOI: 10.1016/j.soh.2025.100112

Ibrahima Mamby Keita , Mariama Diouf , Medoune Ndiop , Boly Diop , Khaly Gueye , Marianne Kouawo , Ousmane Ndiaye , Doudou Sene , Elhadji Mamadou Ndiaye , Marie Khemesse Ngom Ndiaye

Background

Senegal is located in a malaria-endemic zone. Malaria is a highly climate-sensitive vector-borne disease, yet its sentinel surveillance shows a weak integration of malaria morbidity data with climatic factors. Therefore, it is useful to analyse the correlation between these factors in Senegal from 2012 to 2019.

Methods

An analytical cross-sectional study of malaria incidence rate (MIR) with its climatic factors from 2012 to 2019 was carried out. This was followed by predictive modelling of MIR and its climatic factors from 2020 to 2023. A reconstituted database, incorporating data from National Malaria Control Program (initiated by Ministry of Health) and National Agency for Civil Aviation and Meteorology, enabled a multi-variate analysis through a vector auto regression approach using Microsoft Excel 2010 and R 3.6.1 software.

Results

MIR evolved in three phases: initially almost zero from January to May, then gradually increases with an accentuation in August–September, and finally gradually decreases from November to December. However, unlike Podor (0.11 ‰), MIR heterogeneity was seen in Kédougou (12.55 ‰) and Bakel (7.34 ‰). Apart from wind strength and mean temperature which moved in the opposite directions, all other climatic factors evolved in the same dynamics as MIR. MIR followed changes in rainfall and hygrometry with an average lag of (2.5 ± 1.0) months and (1.0 ± 0.5) months, respectively. The causal links between MIR and rainfall showed a decreasing trend in Dakar (P = 4.18 × 10⁻⁶), Ziguinchor (P = 7.95 × 10⁻⁴), Diourbel (P = 1.91 × 10⁻³), Kédougou (P = 4.03 × 10⁻³), and Bakel (P = 3.32 × 10⁻²). In Bakel, additional associations were observed between MIR and both minimum temperature (P = 5.87 × 10⁻³) and maximum temperature (P = 1.22 × 10⁻²) temperatures. Predictive modelling shows an overall downward trend for MIR from 2020 to 2023, with its climatic factors preceding MIR by an average of two months.

Conclusion

This study highlights the importance of synchronous, multi-sectoral, and integrated surveillance of malaria alongside climatic factors to more effectively meet pre-elimination requirements in Senegal.

塞内加尔位于疟疾流行区。疟疾是一种对气候高度敏感的病媒传播疾病，但其哨点监测显示，疟疾发病率数据与气候因素的结合很弱。因此，分析2012年至2019年塞内加尔这些因素之间的相关性是有用的。方法对2012 - 2019年云南省疟疾发病率及其气候因素进行分析研究。随后对2020年至2023年的MIR及其气候因子进行了预测建模。利用由卫生部发起的国家疟疾控制规划和国家民用航空和气象局提供的数据重建数据库，利用Microsoft Excel 2010和r3.6.1软件，通过向量自动回归方法进行多变量分析。结果smir在1 - 5月基本为零，8 - 9月逐渐增大，11 - 12月逐渐减小；然而，与Podor（0.11‰）不同，ksamdodou（12.55‰）和Bakel（7.34‰）的MIR存在异质性。除了风速和平均气温的变化方向相反外，其他气候因子的变化都与MIR相同。MIR随降雨和湿度变化而变化，平均滞后时间分别为（2.5±1.0）个月和（1.0±0.5）个月。达喀尔（P = 4.18 × 10−6）、ziiguinchor （P = 7.95 × 10−4）、Diourbel （P = 1.91 × 10−3）、ksamoudou （P = 4.03 × 10−3）和Bakel （P = 3.32 × 10−2）的MIR与降雨量的因果关系呈下降趋势。在Bakel， MIR与最低温度（P = 5.87 × 10−3）和最高温度（P = 1.22 × 10−2）之间存在额外的关联。预测模型显示，从2020年到2023年，MIR总体呈下降趋势，其气候因子平均比MIR早两个月。结论本研究强调了同步、多部门和综合监测疟疾与气候因素的重要性，以更有效地满足塞内加尔消除疟疾前的要求。

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引用次数: 0

Tackling antimicrobial resistance in the food chain under the One Health umbrella: a systems thinking approach with a focus on Jordan 在同一个健康保护伞下应对食物链中的抗菌素耐药性：以约旦为重点的系统思考方法

Science in One Health

Pub Date : 2025-01-01 DOI: 10.1016/j.soh.2025.100115

Ala'a B. Al-Tammemi , Salam Momani , Hanan Hasan , Amal Obeidat , Muna Horabi

Antimicrobial resistance (AMR) has emerged as a critical public health threat and one of the most complicated global challenges due to its multi-faceted nature. In addition to health burden, AMR also drives up healthcare costs and imposes substantial indirect economic impacts. Despite the ongoing global efforts, the burden of drug-resistant infections is still growing and alarming. Although AMR has been well addressed pertaining to human health, AMR linked to pathogens in other pillars of the food chain has been a hidden menace and a growing public health concern. AMR may arise in the food chain through various pathways, with foodborne drug-resistant pathogens being reported in the literature. Tackling and combatting AMR in the food chain requires a multi-faceted comprehensive approach under the One Health umbrella. This approach is crucial not only to protect public health but also to ensure the sustainability and safety of all components of the food chain.

抗菌素耐药性（AMR）已成为一个重大的公共卫生威胁，也是最复杂的全球挑战之一，因为它具有多方面的性质。除了健康负担外，抗菌素耐药性还推高了医疗成本，并对经济造成重大间接影响。尽管全球正在作出努力，但耐药感染的负担仍在增加，令人震惊。尽管与人类健康有关的抗微生物药物耐药性已经得到了很好的解决，但与食物链其他支柱中的病原体有关的抗微生物药物耐药性一直是一个隐藏的威胁，也是一个日益严重的公共卫生问题。抗生素耐药性可能通过各种途径在食物链中产生，文献中报道了食源性耐药病原体。应对和打击食物链中的抗菌素耐药性需要在“同一个健康”框架下采取多方面的综合办法。这种做法不仅对保护公众健康至关重要，而且对确保食物链所有组成部分的可持续性和安全性也至关重要。

引用次数: 0