Pub Date : 2025-04-01Epub Date: 2025-05-29DOI: 10.1016/j.vacune.2025.500391
Uddalak Das , Soupayan Banerjee , Meghna Sarkar
Circular RNA (circRNA) vaccines are emerging as a revolutionary strategy in cancer immunotherapy, offering novel mechanisms for inducing robust and durable immune responses. Unlike traditional linear mRNA vaccines, circRNAs exhibit exceptional stability, enhanced translational efficiency, and resistance to exonuclease degradation, making them ideal candidates for vaccine development. Recent studies have shown that circRNA vaccines play an important and specialized role in cancer treatment. However, there are currently no relevant bibliometric studies. This study aimed to apply bibliometrics and scientometrics to summarize the knowledge structure and research hotspots regarding the role of circRNA vaccines in cancer. Publications related to circRNA vaccines in cancer were searched on the Scopus database. VOSviewer and Scopus were used to conduct the analyses. This study summarizes the research trends and development of circRNA vaccines for cancer and also a comparative analysis between mRNA cancer vaccine and circRNA cancer vaccine identifying potential areas of focus, innovation and growth. This information will provide a reference for researchers to studying circRNA vaccines against cancer due to its increasing trends over recent times.
{"title":"Bibliometric analysis of circular RNA cancer vaccines and their emerging impact","authors":"Uddalak Das , Soupayan Banerjee , Meghna Sarkar","doi":"10.1016/j.vacune.2025.500391","DOIUrl":"10.1016/j.vacune.2025.500391","url":null,"abstract":"<div><div>Circular RNA (circRNA) vaccines are emerging as a revolutionary strategy in cancer immunotherapy, offering novel mechanisms for inducing robust and durable immune responses. Unlike traditional linear mRNA vaccines, circRNAs exhibit exceptional stability, enhanced translational efficiency, and resistance to exonuclease degradation, making them ideal candidates for vaccine development. Recent studies have shown that circRNA vaccines play an important and specialized role in cancer treatment. However, there are currently no relevant bibliometric studies. This study aimed to apply bibliometrics and scientometrics to summarize the knowledge structure and research hotspots regarding the role of circRNA vaccines in cancer. Publications related to circRNA vaccines in cancer were searched on the Scopus database. VOSviewer and Scopus were used to conduct the analyses. This study summarizes the research trends and development of circRNA vaccines for cancer and also a comparative analysis between mRNA cancer vaccine and circRNA cancer vaccine identifying potential areas of focus, innovation and growth. This information will provide a reference for researchers to studying circRNA vaccines against cancer due to its increasing trends over recent times.</div></div>","PeriodicalId":101272,"journal":{"name":"Vacunas (English Edition)","volume":"26 2","pages":"Article 500391"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144167190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-04-01Epub Date: 2025-05-29DOI: 10.1016/j.vacune.2025.500390
Z. Nafiah , A. Atha , A.I. Rizkita , N.S.O. Ujiantari , A. Hermawan
Breast cancer (BC) remains one of the leading causes of cancer-related morbidity and mortality, owing to genetic mutations and various nongenetic factors. Traditional treatments often induce severe side effects and recurrence risk. Recently, immunotherapy has emerged as a promising alternative, offering prolonged survival and improved quality of life. Multi-epitope vaccines have shown promise by inducing strong immune responses through multiple epitopes, targeting various tumor antigens, and minimizing adverse effects. Advancements in genomic and proteomic technologies have enabled the identification of key antigens for targeted vaccine design. Immunoinformatics and reverse vaccinology have improved epitope mapping, allowing the selection of epitopes that prompt robust immune responses. Synthetic peptide vaccines combining multiple antigens, along with potent adjuvants, have demonstrated enhanced immunogenicity and stronger antitumor responses. This review provides an overview of the development of the multi-epitope vaccine for treating BC, identifying over 18 studies from 2019 to 2024: 9 are in the in silico design stage, 4 in preclinical testing, 2 in phase I clinical trials, and 3 in phase II clinical trials. These studies evaluated 28 immunogenic target antigens, showing promising results in efficacy and safety. Continued research and collaboration will accelerate the development of effective cancer immunotherapies.
{"title":"Recent update on multi-epitope vaccine development for treating breast cancer","authors":"Z. Nafiah , A. Atha , A.I. Rizkita , N.S.O. Ujiantari , A. Hermawan","doi":"10.1016/j.vacune.2025.500390","DOIUrl":"10.1016/j.vacune.2025.500390","url":null,"abstract":"<div><div>Breast cancer (BC) remains one of the leading causes of cancer-related morbidity and mortality, owing to genetic mutations and various nongenetic factors. Traditional treatments often induce severe side effects and recurrence risk. Recently, immunotherapy has emerged as a promising alternative, offering prolonged survival and improved quality of life. Multi-epitope vaccines have shown promise by inducing strong immune responses through multiple epitopes, targeting various tumor antigens, and minimizing adverse effects. Advancements in genomic and proteomic technologies have enabled the identification of key antigens for targeted vaccine design. Immunoinformatics and reverse vaccinology have improved epitope mapping, allowing the selection of epitopes that prompt robust immune responses. Synthetic peptide vaccines combining multiple antigens, along with potent adjuvants, have demonstrated enhanced immunogenicity and stronger antitumor responses. This review provides an overview of the development of the multi-epitope vaccine for treating BC, identifying over 18 studies from 2019 to 2024: 9 are in the <em>in silico</em> design stage, 4 in preclinical testing, 2 in phase I clinical trials, and 3 in phase II clinical trials. These studies evaluated 28 immunogenic target antigens, showing promising results in efficacy and safety. Continued research and collaboration will accelerate the development of effective cancer immunotherapies.</div></div>","PeriodicalId":101272,"journal":{"name":"Vacunas (English Edition)","volume":"26 2","pages":"Article 500390"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144167189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-04-01Epub Date: 2025-05-29DOI: 10.1016/j.vacune.2025.500387
Muhammad Saud , Irfan Wahyudi
Background
The role of media is not only to give information about social matters but it also has a significant role in educating health concerns during the COVID-19 pandemic in Indonesia.
Purpose
The present study investigated how media networks in Indonesia responded to the COVID-19 by providing adaptation strategies to prevent its effects. The current research aims were not only to foster awareness of health issues but also to analyze the role of media in changing public behavior and health concerns.
Methods
The study employs a qualitative research design and interviews were conducted with the general public, including those who were infected with COVID-19, students, and staff working in hospitals, educational institutions, and public service departments. The interviews were analyzed through thematic analysis.
Results
The study's findings reveal that the participants of the study adopted multiple adaptation strategies for the prevention of COVID-19 that have been introduced, including media accessibility for updates, online media engagement for social connectedness, highlighting public health issues, developing trust among communities, and providing social support through media.
Conclusion
The pandemic has brought certain changes in the living patterns of people in Indonesia, and the media has played a greater role by fostering public health information. Furthermore, there has been a significant increase in the usage of media communication channels to disseminate information about the virus and to provide guidance on how the spread can be prevented. The study concludes that media has expectedly contributed to shaping public behavior.
{"title":"Shaping health behavior and social connectedness during COVID-19 through media adaptation strategies in Indonesia","authors":"Muhammad Saud , Irfan Wahyudi","doi":"10.1016/j.vacune.2025.500387","DOIUrl":"10.1016/j.vacune.2025.500387","url":null,"abstract":"<div><h3>Background</h3><div>The role of media is not only to give information about social matters but it also has a significant role in educating health concerns during the COVID-19 pandemic in Indonesia.</div></div><div><h3>Purpose</h3><div>The present study investigated how media networks in Indonesia responded to the COVID-19 by providing adaptation strategies to prevent its effects. The current research aims were not only to foster awareness of health issues but also to analyze the role of media in changing public behavior and health concerns.</div></div><div><h3>Methods</h3><div>The study employs a qualitative research design and interviews were conducted with the general public, including those who were infected with COVID-19, students, and staff working in hospitals, educational institutions, and public service departments. The interviews were analyzed through thematic analysis.</div></div><div><h3>Results</h3><div>The study's findings reveal that the participants of the study adopted multiple adaptation strategies for the prevention of COVID-19 that have been introduced, including media accessibility for updates, online media engagement for social connectedness, highlighting public health issues, developing trust among communities, and providing social support through media.</div></div><div><h3>Conclusion</h3><div>The pandemic has brought certain changes in the living patterns of people in Indonesia, and the media has played a greater role by fostering public health information. Furthermore, there has been a significant increase in the usage of media communication channels to disseminate information about the virus and to provide guidance on how the spread can be prevented. The study concludes that media has expectedly contributed to shaping public behavior.</div></div>","PeriodicalId":101272,"journal":{"name":"Vacunas (English Edition)","volume":"26 2","pages":"Article 500387"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144167289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In recent years, public awareness of the risks posed by zoonotic diseases has significantly increased. Nipah virus (NiV) and Coronavirus are known to cause serious respiratory and neurological effects, while Lassa virus is a hemorrhagic virus. The current study employs an immunoinformatics approach to predict antigenic epitopes against NiV, Lassa virus (LASV), and Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) for the development of multi-epitope vaccines (MEV) and to identify the potential drug molecules using molecular docking approaches.
Results
Thirteen Cytotoxic T lymphocyte (CTL) epitopes for SARS-CoV-2, three for NiV, and three for LASV were selected. Additionally, eight Helper T lymphocyte (HTL) epitopes for NiV, seven for SARS-CoV-2, and five for LASV, all of which demonstrated antigenicity, non-allergenicity, and non-toxicity were identified and included. Molecular docking and subsequent construction of the 3D structure for the best epitopes from each virus revealed stable and strong binding affinities between the MEV and human pathogenic Toll-like receptors (TLRs), specifically TLR3 and TLR8.
Conclusion
This work presents evidence of in silico research on vaccine design and molecular docking against the Nipah, Lassa viruses and SARS-CoV-2 target proteins. It highlights the computational approaches used for drug repurposing and the exploration of natural drug compounds. These findings suggest that the plant-derived or naturally sourced drugs exhibit significant potential in combating viral diseases in humans.
{"title":"Exploring structural proteins of Nipah, Lassa, and coronaviruses for multi-epitope vaccine design using immuno-informatics and in silico studies","authors":"Ananya Saji , Sagaya Jansi Rozario , Balamurugan Shanmugaraj , Praveen Kumar Panthagani","doi":"10.1016/j.vacune.2025.500424","DOIUrl":"10.1016/j.vacune.2025.500424","url":null,"abstract":"<div><h3>Objective</h3><div>In recent years, public awareness of the risks posed by zoonotic diseases has significantly increased. Nipah virus (NiV) and Coronavirus are known to cause serious respiratory and neurological effects, while Lassa virus is a hemorrhagic virus. The current study employs an immunoinformatics approach to predict antigenic epitopes against NiV, Lassa virus (LASV), and Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) for the development of multi-epitope vaccines (MEV) and to identify the potential drug molecules using molecular docking approaches.</div></div><div><h3>Results</h3><div>Thirteen Cytotoxic T lymphocyte (CTL) epitopes for SARS-CoV-2, three for NiV, and three for LASV were selected. Additionally, eight Helper T lymphocyte (HTL) epitopes for NiV, seven for SARS-CoV-2, and five for LASV, all of which demonstrated antigenicity, non-allergenicity, and non-toxicity were identified and included. Molecular docking and subsequent construction of the 3D structure for the best epitopes from each virus revealed stable and strong binding affinities between the MEV and human pathogenic Toll-like receptors (TLRs), specifically TLR3 and TLR8.</div></div><div><h3>Conclusion</h3><div>This work presents evidence of <em>in silico</em> research on vaccine design and molecular docking against the Nipah, Lassa viruses and SARS-CoV-2 target proteins. It highlights the computational approaches used for drug repurposing and the exploration of natural drug compounds. These findings suggest that the plant-derived or naturally sourced drugs exhibit significant potential in combating viral diseases in humans.</div></div>","PeriodicalId":101272,"journal":{"name":"Vacunas (English Edition)","volume":"26 2","pages":"Article 500424"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144167290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-04-01Epub Date: 2025-05-29DOI: 10.1016/j.vacune.2025.500388
A. Hosseingholian , P. Jafari , A. Abedini , H. Jooya , J.D. Gross , M. Beyranvand , A. Samadi , S. Khoshnood
Nanomedicine offers innovative solutions for healthcare, particularly in cancer diagnosis and treatment. Among these, nanoparticles (NPs) synthesized by microbes have gained attention for their unique properties and potential applications. This review explores the methods for microbial nanoparticle (NP) synthesis, their physicochemical characteristics, and their role in cancer therapies, such as targeted drug delivery and imaging. By analyzing their advantages, limitations, and biological interactions, we highlight the impact of biologically derived NPs in advancing cancer treatment and discuss their future prospects in nanomedicine.
{"title":"An overview of anticancer roles of nanoparticles synthesized by microbes","authors":"A. Hosseingholian , P. Jafari , A. Abedini , H. Jooya , J.D. Gross , M. Beyranvand , A. Samadi , S. Khoshnood","doi":"10.1016/j.vacune.2025.500388","DOIUrl":"10.1016/j.vacune.2025.500388","url":null,"abstract":"<div><div>Nanomedicine offers innovative solutions for healthcare, particularly in cancer diagnosis and treatment. Among these, nanoparticles (NPs) synthesized by microbes have gained attention for their unique properties and potential applications. This review explores the methods for microbial nanoparticle (NP) synthesis, their physicochemical characteristics, and their role in cancer therapies, such as targeted drug delivery and imaging. By analyzing their advantages, limitations, and biological interactions, we highlight the impact of biologically derived NPs in advancing cancer treatment and discuss their future prospects in nanomedicine.</div></div>","PeriodicalId":101272,"journal":{"name":"Vacunas (English Edition)","volume":"26 2","pages":"Article 500388"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144167291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-01Epub Date: 2025-03-31DOI: 10.1016/j.vacune.2025.100384
Mohammad Abu-Ghosh , Dareen Saleh , Joud Al-Haddad , Leen Sabbah , Raghad Alnusairat , Muna Barakat , Malik Sallam
Objective
To assess the attitude of senior citizens towards the newly approved respiratory syncytial virus (RSV) vaccines using a novel survey instrument specifically tailored for this purpose.
Material and methods
Based on a literature review on vaccination attitude towards respiratory viruses (SARS-CoV-2 and influenza), 15 items were tested for content, face, and construct validity. Data collection nvolved face-to-face interviews among individuals aged 50 years or older in Jordan during May–June 2024. Construct validity was assessed using exploratory factor analysis (EFA) based on principal component analysis.
Results
A total of 231 respondents formed the final sample. The EFA showed that 5 constructs explained 71.9% of the variance in attitude to RSV vaccination. These constructs were labeled Fear, Information, Accessibility, Benefit, and Conspiracy. The acceptance of a safe and effective RSV vaccine if provided free-of-charge was observed among 55.4% of the participants (n = 128), while 16.0% were hesitant (n = 37), and 28.6% were resistant (n = 66). Applying the 5 RSV vaccine attitude constructs, demographic data, and vaccination history into the multivariate analysis, a higher RSV vaccine acceptance was found among elderly individuals with lower monthly incomes, a history of higher vaccine uptake, agreement with the Benefit construct, and disagreement with the Fear construct.
Conclusions
This study developed an initial survey instrument to assess the attitudes of senior citizens towards the newly approved RSV vaccines. Further testing across diverse settings is necessary to evaluate the barriers and motivators influencing attitude to RSV vaccination. This effort is crucial to reduce the burden of RSV disease among the elderly.
{"title":"Would senior citizens get vaccinated against RSV? Exploratory analysis using a novel survey instrument","authors":"Mohammad Abu-Ghosh , Dareen Saleh , Joud Al-Haddad , Leen Sabbah , Raghad Alnusairat , Muna Barakat , Malik Sallam","doi":"10.1016/j.vacune.2025.100384","DOIUrl":"10.1016/j.vacune.2025.100384","url":null,"abstract":"<div><h3>Objective</h3><div>To assess the attitude of senior citizens towards the newly approved respiratory syncytial virus (RSV) vaccines using a novel survey instrument specifically tailored for this purpose.</div></div><div><h3>Material and methods</h3><div>Based on a literature review on vaccination attitude towards respiratory viruses (SARS-CoV-2 and influenza), 15 items were tested for content, face, and construct validity. Data collection nvolved face-to-face interviews among individuals aged 50 years or older in Jordan during May–June 2024. Construct validity was assessed using exploratory factor analysis (EFA) based on principal component analysis.</div></div><div><h3>Results</h3><div>A total of 231 respondents formed the final sample. The EFA showed that 5 constructs explained 71.9% of the variance in attitude to RSV vaccination. These constructs were labeled Fear, Information, Accessibility, Benefit, and Conspiracy. The acceptance of a safe and effective RSV vaccine if provided free-of-charge was observed among 55.4% of the participants (<em>n</em> = 128), while 16.0% were hesitant (<em>n</em> = 37), and 28.6% were resistant (<em>n</em> = 66). Applying the 5 RSV vaccine attitude constructs, demographic data, and vaccination history into the multivariate analysis, a higher RSV vaccine acceptance was found among elderly individuals with lower monthly incomes, a history of higher vaccine uptake, agreement with the Benefit construct, and disagreement with the Fear construct.</div></div><div><h3>Conclusions</h3><div>This study developed an initial survey instrument to assess the attitudes of senior citizens towards the newly approved RSV vaccines. Further testing across diverse settings is necessary to evaluate the barriers and motivators influencing attitude to RSV vaccination. This effort is crucial to reduce the burden of RSV disease among the elderly.</div></div>","PeriodicalId":101272,"journal":{"name":"Vacunas (English Edition)","volume":"26 1","pages":"Article 100384"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143739602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
White spot syndrome (WSS) is a contagious disease caused by the white spot syndrome virus (WSSV) affecting the shrimp industry mostly in South Asian countries. In the past decade, the incidence of WSSV infection and its prevalence has been raised drastically influencing massive economic loss in the shrimp culture industry. The key challenges in developing vaccines for aquatic organisms like shrimp include the complexity of their immune systems, the need for cost-effective mass production, and practical delivery methods in large-scale. This review explores the plant-based vaccine development as a possible approach to address these issues. Further, this review aims to present an update on the knowledge of WSSV and to explore the possibility of plant systems for the development of vaccines for aquatic organisms, especially for shrimps. This approach could be advantage for WSSV prophylaxis and contribute to the broader field of aquatic disease management.
{"title":"A narrative review on the white spot syndrome virus and the perspective of vaccine development","authors":"Susithra Priyadarshni Mugunthan , Nivetha Loganathan , Balamurugan Shanmugaraj , Harish Mani Chandra","doi":"10.1016/j.vacune.2025.100382","DOIUrl":"10.1016/j.vacune.2025.100382","url":null,"abstract":"<div><div>White spot syndrome (WSS) is a contagious disease caused by the white spot syndrome virus (WSSV) affecting the shrimp industry mostly in South Asian countries. In the past decade, the incidence of WSSV infection and its prevalence has been raised drastically influencing massive economic loss in the shrimp culture industry. The key challenges in developing vaccines for aquatic organisms like shrimp include the complexity of their immune systems, the need for cost-effective mass production, and practical delivery methods in large-scale. This review explores the plant-based vaccine development as a possible approach to address these issues. Further, this review aims to present an update on the knowledge of WSSV and to explore the possibility of plant systems for the development of vaccines for aquatic organisms, especially for shrimps. This approach could be advantage for WSSV prophylaxis and contribute to the broader field of aquatic disease management.</div></div>","PeriodicalId":101272,"journal":{"name":"Vacunas (English Edition)","volume":"26 1","pages":"Article 100382"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143739510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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