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Intestinal Microflora of BALB/c-Mice and Function of Local Immune Cells BALB/c小鼠肠道菌群与局部免疫细胞功能的关系
K. Roszkowski , H.L. Ko , J. Beuth , Y. Ohshima , W. Roszkowski , J. Jeljaszewicz , G. Pulverer

BALB/c-mice were treated for 7 days with oral nonabsorbable dosages of mezlocillin to achieve digestive tract decontamination. Such a procedure resulted in rapid eradication of most species of aerobic and anaerobic intestinal microflora. Various functions of peritoneal macrophages (e. g. chemiluminescence response, chemotactic motility, bactericidal and cytostatic ability) and lymphocyte proliferation were decreased in decontaminated animals as compared to non-treated controls.

BALB/c-Mäuse wurden sieben Tage oral mit Mezlocillin behandelt, um eine Elimination der aeroben und anaeroben Mikroflora des Gastrointestinaltraktes herbeizuführen und deren Auswirkungen zu studieren. Verglichen mit Kontrolltieren zeigten Mezlocillin-behandelte Mäuse mit dekontaminiertem Gastrointestinaltrakt eine Einschränkung der Phagozytose-Aktivität (Chemilumineszenz-Test), der chemotaktischen Beweglichkeit (Chemotaxis-Test), des direkten Abtötungseffektes (Bakterienabtötungstest) und des zytostatischen Effektes (Thymidin-Inkorporationstest) von Peritonealmakrophagen sowie Reduktion der Lymphozytenproliferation.

每天用嘴角吸血魔尾矿该表格的结果是快速消除有氧运动和纳米菌的定律。化学反应、化学反应、淋巴细胞转移和淋巴细胞扩散在违反接触动物的非制约中死亡。BALB/c老鼠被放入口腔7天的梅波西琳治疗,试图建立尾矿库的种植能力和进化性细菌,研究产生的效果。而Kontrolltieren Mezlocillin-behandelte老鼠表现出与dekontaminiertem Gastrointestinaltrakt限制Phagozytose-Aktivität (Chemilumineszenz-Test) chemotaktischen肌肉(Chemotaxis-Test),直接Abtötungseffektes (Bakterienabtötungstest)和zytostatischen Effektes Peritonealmakrophagen (Thymidin-Inkorporationstest)以及减少Lymphozytenproliferation .
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引用次数: 24
CAMP-like Phenomena of Vibrios 弧菌的camp样现象
Werner Köhler

The CAMP test was proposed by Lesmana and Rockhill (11) as a method to differentiate between classical V. cholerae (negative) and V. cholerae biotype El Tor (positive). Typical CAMP phenomena with a crescent-like zone of complete hemolysis were observed also with some strains of V. metschnikovii, V. parahaemolyticus, and V. anguillarum when the cultures were incubated anaerobically (mostly also at aerobic conditions). No CAMP reaction was seen with V. harveyi and V. costicola.

CAMP测试由Lesmana和Rockhill(11)提出,作为区分经典霍乱弧菌(阴性)和霍乱弧菌El - Tor(阳性)的方法。当培养物在厌氧条件下(大多数也在好氧条件下)孵育时,在某些菌株的梅茨尼科夫弧菌、副溶血性弧菌和安古拉弧菌中也观察到典型的CAMP现象,具有月牙状完全溶血带。哈维氏弧菌和costicola弧菌均未见CAMP反应。
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引用次数: 9
Species Identification and Serotyping (Capsular Antigen) of Pasteurella Strains from Sheep Flocks in South Germany and in Syria 德国南部和叙利亚羊群巴氏杆菌菌种鉴定及血清分型(荚膜抗原
Mario Younan, Hans Schmid, Ernst Hellmann

135 Pasteurella strains were cultivated from nasal swabs of sheep as well as pneumonic lungs of dead and slaughtered sheep. The specimen originated from 41 flocks in South Germany and from 15 flocks and 60 slaughter sheep in Syria (Hama region).

Serovariety A2 prevailed amongst P. haemolytica strains (6) isolated in South Germany (53 strains) and in Syria (41 strains). In addition 10 further serovarieties were identified in South Germany (next frequent were A8, A1 and A6) and 7 in Syria. Untypable strains appeared to be more frequent in Syria.

Other Pasteurellae (17) represented ¼ of isolates in Syria and ⅓ of isolates in South Germany. Species identification resulted in P. multocida ssp. multocida (25), P. multocida ssp. septica (4 strains, Syria only), P. canis (3 strains, South Germany only) and Pasteurella-like strains (9 strains). Twelve P. multocida ssp. multocida strains carried capsular antigen D and 7 capsular antigen A.

In most cases where multiple samples were examined from one flock, strains with different capsular antigens and/or belonging to different Pasteurella species were isolated (max. 8).

从羊鼻拭子以及死羊和屠宰羊的肺炎肺中培养出135株巴氏杆菌。该标本来自德国南部的41只羊和叙利亚(哈马地区)的15只羊和60只屠宰羊。在德国南部(53株)和叙利亚(41株)分离的溶血假单胞菌(6株)中,血清变异A2占主导地位。此外,在德国南部发现了10个血清变种(其次是A8、A1和A6),在叙利亚发现了7个。不可描述的菌株似乎在叙利亚更为频繁。其他巴氏杆菌(17)占叙利亚分离株的四分之一和德国南部分离株的三分之一。物种鉴定结果为多杀线虫。multocida (25);脓毒杆菌(4株,仅叙利亚),犬链球菌(3株,仅德国南部)和巴斯德氏杆菌样菌株(9株)。12多杀性p.a。多杀菌株携带荚膜抗原D和7荚膜抗原a。在大多数情况下,从一个群体中检测多个样本,分离出具有不同荚膜抗原和/或属于不同的巴氏杆菌种的菌株(最大。8)。
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引用次数: 3
In vitro-bakterizidieeffekte von ofloxacin bei S. aureus 奥吕斯s
H.C. Korting , W. Maier , M. Schäfer-Korting

Two Staphylococcus aureus (S. aureus) strains with differing susceptibility to penicillin G as expressed by the minimum inhibitory concentration were exposed in vitro over a period of 8 h to the continuously changing concentrations of ofloxacin achieved in human serum and cantharides blister fluid (CBF) after the single oral application of 600 mg. In both strains bacterial density was rapidly, but not totally reduced: a reduction by 99 percent took no longer than about 1 and 1.5 h resp. facing the serum level profile and about 1.5 h facing the tissue level profile. The maximum reduction of staphylococcal density in percent (kn) amounted to 0.0007 and 0.0034 and to 0.0038 and 0.0047 resp. Thus not only the serum level profiles but also the skin tissue level profiles obtainable in man proved highly effective in vitro against S. aureus irrespective of the bacterial suspectibility against penicillin G. Therefore oral ofloxacin should prove useful in staphylococcal diseases especially in so far as cutaneous tissue is involved.

Zwei Staphylococcus aureus (S. aureus)-Stämme mit unterschiedlicher Penicillin G-Empfindlichkeit gemessen an der minimalen Hemmkonzentration (MHK) wurden in vitro über 8 h hinweg den ständig schwankenden Ofloxacin-Konzentrationen ausgesetzt, die beim Menschen in Serum- und Kantharidinblasenflüssigkeit (CBF) nach der einmaligen peroralen Gabe von 600 mg erreicht werden. Bei beiden Stämmen wurde die Bakteriendichte rasch, wenn auch nicht vollständig verringert: eine Reduktion um 99% beanspruchte in Gegenwart des Serumspiegelprofils nur etwa 1 bis 1,5 h.

In Gegenwart des Gewebsspiegelprofils lag dieser Wert bei etwa 1,5 h. Die maximale Verringerung der Staphylokokkendichte in Prozent (kn) belief sich auf 0,0007 und 0,0034, bzw. 0,0038 und 0,0047.

Somit erwies sich nicht nur das beim Menschen erreichbare Serumspiegelprofil, sondern auch das entsprechende Gewebsspiegelprofil als in vitro gegenüber S. aureus überaus wirksam. Dabei spielte die Penicillinempfindlichkeit der Erreger keine wesentliche Rolle. Die orale Anwendung von Ofloxacin bei Staphylokokkenerkrankungen dürfte sich demzufolge als nützlich erweisen, nicht zuletzt, was Hautinfektionen anbetrifft.

两株金黄色葡萄球菌(S. aureus)对青霉素G有不同的敏感性(以最小抑制浓度表示),在体外暴露于单次口服600mg氧氟沙星后,人血清和cantharides水泡液(CBF)中氧氟沙星浓度的连续变化中,时间为8小时。在这两种菌株中,细菌密度迅速下降,但不是完全下降:减少99%的时间分别不超过1和1.5小时。面向血清水平曲线,约1.5 h面向组织水平曲线。葡萄球菌密度最大降低百分比(kn)分别为0.0007和0.0034,0.0038和0.0047。因此,不仅血清水平谱,而且人体皮肤组织水平谱在体外证明对金黄色葡萄球菌非常有效,而不考虑细菌对青霉素g的怀疑。因此,口服氧氟沙星应该证明对葡萄球菌疾病有用,特别是在涉及皮肤组织的情况下。金黄色葡萄球菌(S. aureus)-Stämme体外培养青霉素G-Empfindlichkeit gemessen和der minimalen hemmkonconcentration (MHK) wurden, 8 h体外培养ständig schwankenden Ofloxacin-Konzentrationen ausgesetzt,血清中die beim Menschen -和kantharidinblasenflsigkeit (CBF) nach der inmaligen peroralen Gabe 600 mg erreicht werden。德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国德国0,0038和0,0047。一些研究表明,在体外培养金黄色葡萄球菌 (S. aureus berus)的研究中,有一些研究表明,在体外培养金黄色葡萄球菌 (S. aureus berus berirksam)。dabbei spielte die Penicillinempfindlichkeit der ergerine wesentliche Rolle。Die orale Anwendung von oflo沙星bei Staphylokokkenerkrankungen d rfte siich demzufolge als n tzlich erweisen, nicht zulezt,是Hautinfektionen anbetrifft。
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引用次数: 0
New Inhibitors for Aminoglycoside-Adenylyltransferase 氨基糖苷-腺苷基转移酶新抑制剂
N.A. Saleh , A. Zwiefak , W. Peczyńska-Czoch , M. Mordarski , G. Pulverer

Two hydroxymethyltropolones and two tropolone acetate derivatives were found to inhibit an aminoglycoside-adenylyltranferase in a gentamicin-resistant Escherichia coli strain. The inhibitory effect of tropolones depends on the nature of the aminoglycoside antibiotic subject to adenylation.

Combinations of hydroxymethyltropolones with tobramycin were more active compared with tropolone acetates against gentamicin-resistant strains displaying adenylyltransferase activity. On the contrary a combination of the investigated acetate with gentamicin was of lower activity.

It could be shown that these inhibitors inhibit, to a varying degree, the transfer of radioactive ATP to different aminoglycoside molecules.

Zwei Hydroxymethyltropolone und zwei Tropolonacetat-Verbindungen hemmten die Aminoglykosid-Adenylyl-Transferase eines Gentamycin-resistenten Escherichia coli Stammes. Dieser Hemmeffekt der Tropolone hängt auch ab vom Aminoglykosid-Antibiotikum. Die Kombinationen von Hydroxymethyltropolonen mit Tobramycin waren aktiver als Tropolonazetate gegen Gentamycin-resistente Stämme mit Adenylyltransferase-Aktivität. Demgegenüber erwies sich die Kombination der untersuchten Azetate mit Gentamycin als schwächer wirksam. Es konnte gezeigt Verden, daß diese Hemmsubstanzen den Transfer der radioaktiven ATP auf verschiedene Aminoglykosid-Moleküle im wechselnden Ausmaß hemmten.

发现两种羟甲基曲洛酮和两种醋酸曲洛酮衍生物抑制庆大霉素耐药大肠杆菌菌株的氨基糖苷-腺苷转移酶。tropolones的抑制作用取决于氨基糖苷类抗生素受腺苷化作用的性质。羟甲基曲洛酮与妥布霉素联合使用对庆大霉素耐药菌株具有腺苷基转移酶活性,效果优于醋酸曲洛酮。相反,所研究的醋酸酯与庆大霉素的组合活性较低。可以证明,这些抑制剂在不同程度上抑制放射性ATP向不同氨基糖苷分子的转移。对庆大霉素耐药的大肠杆菌Stammes。氨基糖苷-抗菌素。羟基甲基tropolonen与妥布霉素的结合,也与tropolonazeten与庆大霉素耐药的结合Stämme mit Adenylyltransferase-Aktivität。demgegen,她的研究表明,在异丙二酸与庆大霉素的组合下,也可以schwächer工作。[2] [3] [1] [3] [3] [3] [3] [3] [3] [3] [4] [3] [4] [4]
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引用次数: 2
Numerical classification of campylobacters by DNA-restriction endonuclease analysis 弯曲杆菌的dna限制性内切酶数值分类
D. Bruce , J.V. Hookey , Sheena A. Waitkins

Reference strains from five different species of Campylobacter were examined by DNA-restriction endonuclease analysis. The DNA profiles were resolved as absorbence peaks and converted to numerical values which were analysed by a Sirius microprocessor. The percentage similarity between each profile was calculated and the strains clustered together by the computer on shared similarities and the results displayed as an abbreviated dendrogram.

Each of the species of Campylobacter were clearly separated from each other and the different biotypes within a species could also be differentiated.

采用dna限制性内切酶法对5种弯曲杆菌的参考菌株进行了检测。DNA谱被分解为吸收峰,并转换为数值,由Sirius微处理器进行分析。计算每个剖面之间的相似性百分比,并通过计算机将菌株聚集在一起,并将结果显示为简短的树状图。弯曲杆菌的不同种之间有明显的区隔,并且可以区分同一种内的不同生物型。
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引用次数: 10
Studies on Serum Resistance in E scherichia coli 大肠杆菌血清耐药性研究
Britta S. Kubens, Wolfgang Opferkuch

Serum-sensitive mutants and their serum-resistant smooth parental E. coli strains (Wf8, Wf26, and WF 52) have been investigated in respect to their binding of different complement components. These pairs consisting of a wild-type and its mutants represent a better model for the investigation of the mechanism of serum resistance than the comparison of unrelated strains. Both strains of a pair bind equivalent amounts of C3. In binding assays using radiolabeled terminal components C6, C7, C8, and C9, the serum-sensitive strains do bind more late acting components than their resistant parental strains. An active membrane attack complex stably bound to the cell surface was found on the mutants, whereas with wild-type bacteria a complex could be isolated from the supernatant which is composed of the late acting complement components and S-protein. This complex is released from the surface of the wild-type bacteria without participation of C9.

研究了血清敏感突变体及其血清耐药平滑亲本大肠杆菌菌株(Wf8、Wf26和wf52)与不同补体成分的结合情况。这些由野生型及其突变体组成的菌株对血清耐药机制的研究比不相关菌株的比较更好。一对中的两株结合等量的C3。在使用放射标记的末端组分C6、C7、C8和C9的结合试验中,血清敏感菌株确实比它们的抗性亲本菌株结合更多的晚期作用组分。在突变体上发现了一个稳定结合在细胞表面的活性膜攻击复合物,而在野生型细菌上清中可以分离到一个由晚期补体成分和s蛋白组成的复合物。这种复合物在没有C9参与的情况下从野生型细菌表面释放出来。
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引用次数: 5
Studies on a Biological Response Modifying LYSAT from Propionibacterium avidum KP 40 禽丙酸杆菌KP 40生物反应修饰LYSAT的研究
G. Pulverer , H.L. Ko , J. Beuth , K. Roszkowski , W. Roszkowski , J. Jeljaszewicz

Propionibacterium avidum KP 40 cells were mechanically disintegrated in order to obtain the soluble immunostimulatory (antineoplastic) LYSAT. Chemiluminescence measurements of human leukocyte function yielded enhanced activation of the cells after incubation with 2.5 and 5 mg of LYSAT. As compared to non-treated controls, administration of LYSAT to BALB/c-mice (1, 2.5 and 5 mg; intraperitoneally, subcutaneously, intranasal; 7, 4 and 2 days prior to challenge) induced a significant enlargement of the spleen as well as significantly reduced sarcoma L-1 lung colonization 14 days after challenge and evidently enhanced chemiluminescence response of peritoneal macrophages.

Propionibacterium avidum KP 40 Zellen wurden in einer Zellmühle mechanisch aufgelöst und weiter verarbeitet zum Immunstimulans LYSAT. Im Chemilumineszenz-Test offenbarten menschliche Leukozyten (Granulozyten und Monozyten) nach Inkubation mit 2,5 und 5 mg LYSAT eine gesteigerte Aktivität. Im Vergleich mit einer unbehandelten Kontroll-gruppe bewirkte die dreimalige LYSAT-Gabe in BALB/c-Mäusen (1, 2,5 und 5 mg; intraperitoneal, subkutan, nasal; 7, 4 und 2 Tage vor Testbeginn) eine signifikante Gewichtszunahme der Milz sowie eine signifikant reduzierte Anzahl von Lungenmetastasen 14 Tage nach Tumorzellinokulation und eine deutlich gesteigerte Aktivität der Peritoneal-makrophagen im Chemilumineszenz-Assay.

采用机械崩解方法,获得可溶性免疫刺激(抗肿瘤)LYSAT。人白细胞功能的化学发光测量显示,在2.5和5mg LYSAT孵育后,细胞的活化增强。与未处理的对照组相比,给BALB/c小鼠LYSAT(1,2.5和5mg;腹腔内、皮下、鼻内;攻毒前7、4和2天)诱导脾脏显著增大,攻毒后14天显著减少肉瘤L-1肺定植,并明显增强腹腔巨噬细胞的化学发光反应。猪丙酸杆菌KP 40 Zellen wurden在einer zellm机制aufgelöst和weiter verarbeitet zum免疫刺激剂LYSAT。每次孵育2、5、5 mg LYSAT eine gesteigerte Aktivität。在BALB/c-Mäusen(1、2、5和5 mg)中对LYSAT-Gabe进行预处理的对照组;腹膜内,腹下,鼻;7 4 2天伏尔Testbeginn)一张signifikante Gewichtszunahme der Milz和一张signifikant reduzierte Anzahl冯Lungenmetastasen 14天Tumorzellinokulation票和一张deutlich gesteigerte Aktivitat der Peritoneal-makrophagen Chemilumineszenz-Assay化生。
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引用次数: 4
The Importance of Different Laboratory Methods in Legionella Diagnosis in Medical Care 不同实验室方法在军团菌诊断中的重要性
W. Mathys , E. Junge , Ch. Sobek-Pfeiffer , H. Bösenberg , M. von Eiff

For the outbreak of diseases caused by Legionellae an infection by contaminated water is thought to be responsible. In the environment of patients with a high risk of infection (e. g. after kidney transplantation, immunosuppression) prophylactic measures (rising the temperature of the warm water to 60 °C) should be combined with bacteriological controls. It has to be taken into account, however, that only by taking a couple of samples from the same outlet during a period of time a colonization of central installation systems (sediments, storage tanks) can be discovered. In patients with acute pneumonia of unknown origin serological tests of Legionella antibodies are not very specific. Antibody titers of not infected and with Legionella infected patients show no significant difference. Well suited for the diagnosis of a legionellosis is the use of the Direct Immunofluorescent Antibody Assay (DFA) in invasively sampled specimens. In immunocompromised pneumonia patients 18.3% of bronchoalveolar lavages and 16.0% of bronchoalveolar aspirates are Legionella positive.

Für den Ausbruch von Legionellen-Erkrankungen wird im allgemeinen die Infektion durch kontaminiertes Wasser als Ursache angenommen. In der Umgebung gefährdeter Patienten (z.B. nach Nierentransplantation, Immunsuppression) sollten deshalb vorsorgliche Maßnahmen (Erhöhung der Warmwassertemperatur auf 60 °C) mit bakteriologischen Kontrollen kombiniert werden. Dabei ist zu bedenken, daß nur durch Erfassen mehrerer Wasserproben nach dem öffnen der Wasserzapfstelle zentrale Keimreservoire (z. B. Sediment, Wassertanks) erkennbar werden. Bei akuten unklaren Lungenerkrankungen sind serologische Untersuchungen auf Legionellenantikörper wenig spezifisch. Antikörpertiter von nicht-infizierten und mit Legionella infizierten Patienten zeigen keine signifikanten Unterschiede. Als gut geeignete Methode zur Diagnose einer Legionellose erweist sich der Einsatz des Direkten Immunofluoreszenztests (DFA) bei bronchoskopisch gewonnenen Materialien. Bei immunsupprimierten Pneumonie-Patienten ergaben sich 18,3% positive Befunde in der Bronchiallavage und 16,0% im Bronchialsekret.

对于军团菌引起的疾病爆发,被污染的水的感染被认为是负责任的。在感染高危患者的环境中(如肾移植后、免疫抑制),应采取预防措施(将温水温度升高至60℃)并结合细菌学控制。然而,必须考虑到,只有在一段时间内从同一出口采集几个样本,才能发现中央安装系统(沉积物,储罐)的定植。在不明原因急性肺炎患者中,军团菌抗体的血清学检测不具有特异性。未感染和军团菌感染患者的抗体滴度无显著差异。在侵入性取样标本中使用直接免疫荧光抗体测定(DFA)非常适合军团菌病的诊断。在免疫功能低下的肺炎患者中,18.3%的支气管肺泡灌洗液和16.0%的支气管肺泡吸出液呈军团菌阳性。[8] [j] [j] [j] [j] [j] [j]。In der Umgebung gefährdeter Patienten (z.b.n ach Nierentransplantation, immunosuppression) sollten deshalb vorsorgliche Maßnahmen (Erhöhung der warmwassertemperature auf 60°C) mit bakteriologischen Kontrollen kombiniert werden。Dabei ist zu bedenken, dasunur durch Erfassen mehrerer Wasserproben nach dem öffnen der Wasserzapfstelle zentrale keimreservoir (z. B. Sediment, Wassertanks) erkennbar werden。北碚akuten unklaren Lungenerkrankungen sinologische Untersuchungen auf Legionellenantikörper wenig spezifisch。Antikörpertiter von nicht-infizierten and mit Legionella infizierten patientzeigen keine signalkanten Unterschiede。采用直接免疫荧光试验(DFA)诊断支气管肺组织病变的方法。免疫原性肺炎患者中,支气管灌洗液中Befunde阳性18.3%,支气管灌洗液中Befunde阳性16.0%。
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引用次数: 4
In Vitro Influence of Mycoplasma Species on the Stimulation of Human Polymorphonuclear Granulocytes 支原体对体外刺激人多形核粒细胞的影响
Rea Krausse , Uwe Ullmann , Christel Wagener

The influence of Mycoplasma species ( sp.) on the stimulation of human polymorphonuclear neutrophil granulocytes (PMNG) was determined by means of the luminol-dependent chemiluminescence (CL) method. When opsonized Mycoplasma sp. were used the CL response of PMNG was greater than in the presence of nonopsonized strains. Nonopsonized and nonspecifically opsonized Mycoplasma sp. showed a different CL response pattern. The stimulation of PMNG was with M. pneumoniae significantly weaker than with the other Mycoplasma sp. Using isolated M. hominis strains always the same CL-reaction of PMNG was observed. On the other hand, with 12 isolated U. urealyticum strains different results were obtained; 9 strains isolated from the upper urogenital tract lead to a slight PMNG stimulation comparable to that of M. pneumoniae. No correlation was found between CL response and bacterial killing. The weak stimulation of PMNG by M. pneumoniae and most of the U. urealyticum isolates suggest that this behaviour could be a factor of pathogenicity.

用鲁米诺依赖性化学发光(CL)法测定了支原体对人多形核中性粒细胞(PMNG)的刺激作用。当使用调理支原体时,PMNG的CL反应大于未调理的支原体。非调理和非特异性调理支原体表现出不同的CL反应模式。PMNG对肺炎支原体的刺激作用明显弱于对其他支原体的刺激作用。用分离的人支原体菌株观察PMNG的cl -反应始终相同。另一方面,对12株解脲酵母菌分离得到不同的结果;从上泌尿生殖道分离的9株菌株导致与肺炎支原体相当的轻微PMNG刺激。没有发现CL反应与细菌杀灭之间的相关性。肺炎分枝杆菌和大多数解脲菌分离株对PMNG的微弱刺激表明,这种行为可能是致病性的一个因素。
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引用次数: 3
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Zentralblatt für Bakteriologie, Mikrobiologie und Hygiene. Series A: Medical Microbiology, Infectious Diseases, Virology, Parasitology
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