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Un “boxing” the reality: Knowledge, attitude, and perception of orthodontists, dental practitioners, and orthodontic patients toward mouthguards' wear during contact sports—A cross-sectional study 不 "拳击 "现实:正畸医生、牙科医生和正畸患者对接触性运动中佩戴护齿的认识、态度和看法--横断面研究
IF 1.8 Q3 Dentistry Pub Date : 2024-06-04 DOI: 10.1002/cre2.904
Shailaja Raghavan, Elham S. Abu Alhaija, Yousef Nasrawi, Susan Al- Khateeb, Samer Sunna

Introduction

Mouthguards (MGs) have the potential to prevent contact sport-related dental injuries. However, varying perceptions of their effectiveness persist, influencing recommendations by dental professionals.

Aim

To assess the attitudes, knowledge, and perceptions of orthodontists, other dental practitioners (general dentists and other dental specialists), and orthodontic patients involved in contact sports regarding the use of MGs.

Methodology

A cross-sectional survey was designed to collect information from dental clinicians (orthodontists and other dental practitioners) and their orthodontic patients about using MGs during sports participation. A convenience sampling technique was used to recruit the participants for an online survey. A total of 107 (32 males/75 females) dental clinicians and 147 (75 males/72 females) orthodontic patients (mean age 17.5 ± 5.84 years) participated in the study. Pre-validated questionnaires, specifically designed for dental clinicians and orthodontic patients, were used. Data were analyzed using SPSS software (version 28.0; SPSS).

Results

Nearly 50% of dental clinicians have recently recommended MGs to their patients in their clinical practice out of which 59% preferred the stock type; 33% of dental clinicians enquired their patients about involvement in contact sports during initial visits. The majority of orthodontic patients acquired knowledge about MGs through the Internet. More than half of orthodontic patients expressed unwillingness to pay for MGs, and 89% of orthodontic patients found using MGs during contact sports uncomfortable.

Conclusion

The findings provide valuable insights into the practices and attitudes of dental clinicians and orthodontic patients regarding MGs, their recommendations, and the comfort levels associated with using them during contact sports.

导言 护齿器(MGs)具有预防与接触性运动相关的牙科损伤的潜力。然而,人们对其有效性的不同认识一直影响着牙科专业人员的建议。 目的 评估正畸医师、其他牙科从业人员(普通牙医和其他牙科专家)以及参与接触性运动的正畸患者对使用护齿的态度、知识和看法。 方法 设计了一项横断面调查,以收集牙科临床医生(正畸医生和其他牙科从业人员)及其正畸患者关于在参加体育运动时使用制动喷雾器的信息。调查采用方便抽样技术,招募参与者参与在线调查。共有 107 名(32 名男性/75 名女性)牙科临床医师和 147 名(75 名男性/72 名女性)正畸患者(平均年龄为 17.5 ± 5.84 岁)参与了研究。研究采用了专门为牙科临床医生和正畸患者设计的、经过预先验证的问卷。数据使用 SPSS 软件(28.0 版;SPSS)进行分析。 结果 近 50%的牙科临床医生最近在临床实践中向患者推荐了MGs,其中59%的人更喜欢股票型MGs;33%的牙科临床医生在初次就诊时询问了患者参与接触性运动的情况。大多数正畸患者都是通过互联网获得有关制粒剂的知识的。超过半数的正畸患者表示不愿意支付制粒剂的费用,89%的正畸患者认为在接触性运动中使用制粒剂不舒服。 结论 这些研究结果为了解牙科临床医生和正畸患者对制导喷雾剂的做法和态度、对制导喷雾剂的建议以及在接触性运动中使用制导喷雾剂的舒适度提供了宝贵的见解。
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引用次数: 0
Comparative assessment of flexural strength of monolithic zirconia with different thicknesses and two sintering techniques 不同厚度和两种烧结技术的整体氧化锆抗弯强度比较评估
IF 1.8 Q3 Dentistry Pub Date : 2024-05-31 DOI: 10.1002/cre2.856
Nilofar Karbasian, Amirhossein Fathi, Pirooz Givehchian, Saeed Nosouhian, Mohammad Jamshidian, Farhad Almassi, Ali Fazeli

Objectives

This study aimed to compare the flexural strength of monolithic zirconia with different thicknesses and two sintering techniques.

Materials and Methods

This in vitro, experimental study was conducted on 28 monolithic zirconia discs with 10 mm diameter and 0.5 (n = 14) and 1.2 mm (n = 14) thickness. Each group was divided into two subgroups (n = 7) for fast (60 min) and conventional (120 min) sintering at 1450°C. After sintering, the specimens were thermocycled and their flexural strength was measured by piston-on-3-balls technique in a universal testing machine (0.5 mm/min, 1.2 mm pin diameter). Data were analyzed by the Weibull test, one-way analysis of variance, and Tukey's test (α = .05).

Results

The flexural strength of specimens with 1.2 mm thickness was significantly higher than that of specimens with 0.5 mm thickness (p < .05). The flexural strength of 1.2 mm/120-min group was slightly, but not significantly, higher than that of 1.2 mm/60-min group (p > .05). The flexural strength of 0.5 mm/120-min group was slightly, but not significantly, higher than that of 0.5 mm/60-min group (p > .05).

Conclusion

The increase in thickness of monolithic zirconia increases its flexural strength; however, increasing the sintering time appears to have no significant effect on the flexural strength of monolithic zirconia.

研究目的本研究旨在比较不同厚度和两种烧结技术的整体氧化锆的抗弯强度:这项体外实验研究的对象是 28 个直径为 10 毫米、厚度为 0.5 毫米(n = 14)和 1.2 毫米(n = 14)的整体氧化锆盘。每组分为两个子组(n = 7),分别在 1450°C 下进行快速(60 分钟)和传统(120 分钟)烧结。烧结后,对试样进行热循环,并在万能试验机(0.5 毫米/分钟,针直径 1.2 毫米)上采用活塞对 3 球技术测量其抗弯强度。数据分析采用 Weibull 检验、单因素方差分析和 Tukey 检验(α = .05):结果:厚度为 1.2 毫米的试样的抗弯强度明显高于厚度为 0.5 毫米的试样(p .05)。0.5 毫米/120 分钟组的抗折强度略高于 0.5 毫米/60 分钟组,但不明显(p > .05):结论:增加整体氧化锆的厚度可提高其抗弯强度;但增加烧结时间似乎对整体氧化锆的抗弯强度没有明显影响。
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引用次数: 0
The relationship between oral frailty and oral dysbiosis among hospitalized patients aged older than 50 years 50 岁以上住院病人口腔虚弱与口腔菌群失调之间的关系。
IF 1.8 Q3 Dentistry Pub Date : 2024-05-30 DOI: 10.1002/cre2.890
Yen-Chin Chen, En-Ni Ku, Pei-Fang Tsai, Che-Wei Lin, Nai-Ying Ko, Shun-Te Huang, Jiun-Ling Wang, Yi-Ching Yang

Objective

This study aimed to clarify the relationship between oral frailty and oral dysbiosis among hospitalized patients aged ≥ 50 years.

Methods

A prospective observational study was conducted. Number of teeth, masticatory ability, articulatory oral motor skill, tongue pressure, swallowing pressure, and choking were used to assess oral frailty. Saliva samples were collected from the oral cavity for bacterial culture.

Results

A total 103 in patients enrolled and 53.4% suffered from oral frailty. Oral frailty was found to have a 3.07-fold correlation with the presence of Enterobacterales in the oral cavity (p = 0.037), especially in poor articulatory oral motor skill, which showed at greater risk of Enterobacterales isolated from the oral cavity by 5.58-fold (p = 0.01).

Conclusion

Half of hospitalized patients was found to have oral frailty that was related to more Enterobacterales in the oral cavity. This evidence suggests that the enhancement of articulatory oral motor skills may serve as a potential strategy for mitigating the presence of Enterobacterales within the oral cavity.

研究目的本研究旨在阐明年龄≥50 岁的住院患者口腔虚弱与口腔菌群失调之间的关系:方法:进行前瞻性观察研究。采用牙齿数量、咀嚼能力、发音口腔运动技能、舌压、吞咽压力和呛咳来评估口腔虚弱程度。从口腔采集唾液样本进行细菌培养:结果:共有 103 名患者入选,其中 53.4% 患有口腔虚弱症。发现口腔虚弱与口腔中肠杆菌的存在有 3.07 倍的相关性(p = 0.037),尤其是发音口腔运动技能差的患者,从口腔中分离出肠杆菌的风险更高,达到 5.58 倍(p = 0.01):结论:半数住院病人的口腔功能虚弱与口腔中更多的肠杆菌有关。这些证据表明,提高口腔运动技能可能是减少口腔中肠杆菌的潜在策略。
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引用次数: 0
Assessing the suitability of fused deposition modeling to produce acrylic removable denture bases 评估熔融沉积模型是否适用于制作丙烯酸活动义齿基托。
IF 1.8 Q3 Dentistry Pub Date : 2024-05-27 DOI: 10.1002/cre2.880
Khalid K. Alanazi, Duncan Wood, Joanna Shepherd, Christopher W. Stokes, Ilida Ortega Asencio

Objective

To study the feasibility of using poly methyl methacrylate (PMMA) filament and fused deposition modeling (FDM) to manufacture denture bases via the development of a study that considers both conventional and additive-based manufacturing techniques.

Materials and Methods

Five sample groups were compared: heat and cold cured acrylic resins, CAD/CAM milled PMMA, 3D-printed PMMA (via FDM), and 3D-printed methacrylate resin (via stereolithography, SLA). All groups were subjected to mechanical testing (flexural strength, impact strength, and hardness), water sorption and solubility tests, a tooth bonding test, microbiological assessment, and accuracy of fit measurements. The performance of sample groups was referred to ISO 20795-1 and ISO/TS 19736. The data was analyzed using one-way ANOVA.

Results

Samples manufactured using FDM performed within ISO specifications for mechanical testing, water sorption, and solubility tests. However, the FDM group failed to achieve the ISO requirements for the tooth bonding test. FDM samples presented a rough surface finish which could ultimately encourage an undesirable high level of microbial adhesion. For accuracy of fit, FDM samples showed a lower degree of accuracy than existing materials.

Conclusions

Although FDM samples were a cost-effective option and were able to be quickly manufactured in a reproducible manner, the results demonstrated that current recommended testing regimes for conventionally manufactured denture-based polymers are not directly applicable to additive-manufactured denture base polymers. Therefore, new standards should be developed to ensure the correct implementation of additive manufacturing techniques within denture-based fabrication workflow.

目的:研究使用聚甲基丙烯酸甲酯(PMMA)长丝和熔融沉积建模(FDM)制造义齿基托的可行性,同时考虑传统制造技术和增材制造技术:比较了五组样品:热固化和冷固化丙烯酸树脂、CAD/CAM 铣削 PMMA、3D 打印 PMMA(通过 FDM)和 3D 打印甲基丙烯酸酯树脂(通过立体光刻,SLA)。所有样品组都接受了机械测试(抗弯强度、冲击强度和硬度)、吸水性和溶解性测试、牙齿粘合测试、微生物评估和配合精度测量。样品组的性能参照了 ISO 20795-1 和 ISO/TS 19736 标准。数据采用单因素方差分析:结果:使用 FDM 制造的样品在机械测试、吸水性和溶解性测试中均符合 ISO 规范。但是,FDM 组在牙齿粘合测试中未能达到 ISO 的要求。FDM 制成的样品表面粗糙,最终可能会助长微生物的大量附着。在贴合精度方面,FDM 样品的精度低于现有材料:尽管 FDM 样品是一种具有成本效益的选择,而且能够以可重复的方式快速制造,但结果表明,目前针对传统制造的义齿基底聚合物所推荐的测试制度并不能直接适用于添加剂制造的义齿基底聚合物。因此,应制定新的标准,以确保在义齿基托制造工作流程中正确使用添加剂制造技术。
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引用次数: 0
Frequency of apical periodontitis in root-filled teeth restored with post and core: A 5-year retrospective study 使用桩核修复根充牙的根尖牙周炎发病率:一项为期 5 年的回顾性研究。
IF 1.8 Q3 Dentistry Pub Date : 2024-05-26 DOI: 10.1002/cre2.881
Louise Johansson, Jakob Jonsson Sjögren, Anders Wirén, Alf Eliasson, Fredrik Frisk

Background

In conjunction with post placement in root-filled teeth with periapical healthy conditions, root canal retreatment may be performed to improve the seal of the root canal. Whether root canal retreatment for technical reasons (retreatments in teeth without apical periodontitis (AP)) results in lower frequency of AP is unknown.

Objective

To examine whether there is a difference in frequency of AP between roots with root canals retreated for technical reasons, and roots with root canals not retreated before post placement, with a minimum follow-up of 5 years. Also, to examine changes in root filling quality following root canal retreatment for technical reasons.

Methods

This retrospective study included radiographs of 441 root-filled roots without periapical radiolucencies at baseline, scheduled for post and core treatment. Follow-up data for a minimum of 5 years were available for 305 roots (loss to follow-up 30.8%), 46 of which were retreated for technical reasons. Two calibrated observers assessed root filling sealing quality and length, respectively, and periapical status according to the Periapical Index. The main outcome of the study, AP, was used as the dependent variable and all analyses were performed at root level.

Results

The overall frequency of AP at follow-up was 13.8%. The difference in frequency of AP between retreated (4.3%) and nonretreated (15.4%) root canals was not statistically significant, p = .061. Analyses including only roots with preoperatively inadequate root filling quality showed a statistically significant difference (p = .017) between the two treatment groups (2.4% vs. 22.9%).

Conclusions

Root canal retreatment for technical reasons before post and core placement significantly reduces the frequency of AP in roots with inadequate root filling quality.

背景:在根尖周健康的根充盈牙齿上放置根管柱的同时,可以进行根管再治疗以改善根管的密封性。由于技术原因进行根管再治疗(在没有根尖牙周炎(AP)的牙齿上进行根管再治疗)是否会降低 AP 的发生频率,目前尚不清楚:目的:在至少 5 年的随访中,研究因技术原因进行根管再治疗的牙根与在植入支架前未进行根管再治疗的牙根之间发生 AP 的频率是否存在差异。同时,研究因技术原因进行根管再治疗后根管充填质量的变化:这项回顾性研究包括对 441 个基线时无根尖周放射状突起、计划进行根管治疗和核心治疗的根充根进行放射摄影。对 305 根牙根进行了至少 5 年的随访(随访损失率为 30.8%),其中 46 根因技术原因进行了根管治疗。两名经过校准的观察员分别评估了牙根充填密封的质量和长度,并根据根尖周指数评估了根尖周状况。研究的主要结果 AP 为因变量,所有分析均在牙根水平上进行:随访中出现 AP 的总频率为 13.8%。经修复的根管(4.3%)和未经修复的根管(15.4%)之间的 AP 频率差异无统计学意义,P = 0.061。仅对术前根充质量不合格的根进行分析,结果显示两组根管治疗之间的差异有统计学意义(p = .017)(2.4% 对 22.9%):结论:在桩核置入前因技术原因进行根管再治疗可显著降低根充质量不合格的牙根发生 AP 的频率。
{"title":"Frequency of apical periodontitis in root-filled teeth restored with post and core: A 5-year retrospective study","authors":"Louise Johansson,&nbsp;Jakob Jonsson Sjögren,&nbsp;Anders Wirén,&nbsp;Alf Eliasson,&nbsp;Fredrik Frisk","doi":"10.1002/cre2.881","DOIUrl":"10.1002/cre2.881","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>In conjunction with post placement in root-filled teeth with periapical healthy conditions, root canal retreatment may be performed to improve the seal of the root canal. Whether root canal retreatment for technical reasons (retreatments in teeth without apical periodontitis (AP)) results in lower frequency of AP is unknown.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To examine whether there is a difference in frequency of AP between roots with root canals retreated for technical reasons, and roots with root canals not retreated before post placement, with a minimum follow-up of 5 years. Also, to examine changes in root filling quality following root canal retreatment for technical reasons.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective study included radiographs of 441 root-filled roots without periapical radiolucencies at baseline, scheduled for post and core treatment. Follow-up data for a minimum of 5 years were available for 305 roots (loss to follow-up 30.8%), 46 of which were retreated for technical reasons. Two calibrated observers assessed root filling sealing quality and length, respectively, and periapical status according to the Periapical Index. The main outcome of the study, AP, was used as the dependent variable and all analyses were performed at root level.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The overall frequency of AP at follow-up was 13.8%. The difference in frequency of AP between retreated (4.3%) and nonretreated (15.4%) root canals was not statistically significant, <i>p</i> = .061. Analyses including only roots with preoperatively inadequate root filling quality showed a statistically significant difference (<i>p</i> = .017) between the two treatment groups (2.4% <i>vs</i>. 22.9%).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Root canal retreatment for technical reasons before post and core placement significantly reduces the frequency of AP in roots with inadequate root filling quality.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.881","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141154069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Green synthesis of silver nanoparticles and evaluation of their effects on the Porphyromonas gingivalis bacterial biofilm formation 银纳米粒子的绿色合成及其对牙龈卟啉单胞菌生物膜形成影响的评估。
IF 1.8 Q3 Dentistry Pub Date : 2024-05-26 DOI: 10.1002/cre2.887
Morad Hedayatipanah, Leila Gholami, Abbas Farmany, Mohammad Yusef Alikhani, Amirarsalan Hooshyarfard, Fahime Sadat Hashemiyan

Objective

This study aimed to evaluate the impact of silver nanoparticles (AgNPs) synthesized from propolis on the formation of Porphyromonas gingivalis biofilms.

Material and Methods

AgNPs were synthesized from propolis, and their inhibitory effect on P. gingivalis biofilm formation was assessed. Different concentrations of AgNPs (0.1%, 0.3%, and 0.5%) were tested to determine the dose-dependent antibacterial activity.

Results

The results of this study indicated that AgNPs exhibited an inhibitory effect on P. gingivalis biofilm formation. The antibacterial activity of AgNPs was dose-dependent, with concentrations of 0.1%, 0.3%, and 0.5% showing effectiveness. Notably, the concentration of 0.5% demonstrated the most significant anti-biofilm formation activity.

Conclusion

The results of this study suggest that AgNPs synthesized from propolis have potential as an effective option for enhancing periodontal treatment outcomes. The inhibitory effect of AgNPs on P. gingivalis biofilm formation highlights their potential as alternative antimicrobial agents in the management of periodontal diseases.

研究目的本研究旨在评估由蜂胶合成的银纳米粒子(AgNPs)对牙龈卟啉单胞菌生物膜形成的影响:从蜂胶中合成 AgNPs,并评估其对牙龈卟啉单胞菌生物膜形成的抑制作用。测试了不同浓度的 AgNPs(0.1%、0.3% 和 0.5%),以确定其抗菌活性的剂量依赖性:研究结果表明,AgNPs 对牙龈脓胞生物膜的形成具有抑制作用。AgNPs 的抗菌活性呈剂量依赖性,浓度为 0.1%、0.3% 和 0.5% 时均有效。值得注意的是,0.5% 的浓度具有最显著的抗生物膜形成活性:本研究结果表明,由蜂胶合成的 AgNPs 有潜力成为提高牙周治疗效果的有效选择。AgNPs对牙龈脓胞生物膜形成的抑制作用凸显了其作为替代抗菌剂治疗牙周疾病的潜力。
{"title":"Green synthesis of silver nanoparticles and evaluation of their effects on the Porphyromonas gingivalis bacterial biofilm formation","authors":"Morad Hedayatipanah,&nbsp;Leila Gholami,&nbsp;Abbas Farmany,&nbsp;Mohammad Yusef Alikhani,&nbsp;Amirarsalan Hooshyarfard,&nbsp;Fahime Sadat Hashemiyan","doi":"10.1002/cre2.887","DOIUrl":"10.1002/cre2.887","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study aimed to evaluate the impact of silver nanoparticles (AgNPs) synthesized from propolis on the formation of <i>Porphyromonas gingivalis</i> biofilms.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>AgNPs were synthesized from propolis, and their inhibitory effect on <i>P. gingivalis</i> biofilm formation was assessed. Different concentrations of AgNPs (0.1%, 0.3%, and 0.5%) were tested to determine the dose-dependent antibacterial activity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The results of this study indicated that AgNPs exhibited an inhibitory effect on <i>P. gingivalis</i> biofilm formation. The antibacterial activity of AgNPs was dose-dependent, with concentrations of 0.1%, 0.3%, and 0.5% showing effectiveness. Notably, the concentration of 0.5% demonstrated the most significant anti-biofilm formation activity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The results of this study suggest that AgNPs synthesized from propolis have potential as an effective option for enhancing periodontal treatment outcomes. The inhibitory effect of AgNPs on <i>P. gingivalis</i> biofilm formation highlights their potential as alternative antimicrobial agents in the management of periodontal diseases.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10203,"journal":{"name":"Clinical and Experimental Dental Research","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cre2.887","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141154131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparing the effects of Bone+B® xenograft and InterOss® xenograft bone material on rabbit calvaria bone defect regeneration 比较 Bone+B® 异种移植骨材料和 InterOss® 异种移植骨材料对兔小腿骨缺损再生的影响。
IF 1.8 Q3 Dentistry Pub Date : 2024-05-26 DOI: 10.1002/cre2.875
Afshin Yadegari Naini, Sepehr Kobravi, Aida Jafari, Mohammadhassan Lotfalizadeh, Narges Lotfalizadeh, Sareh Farhadi

Background

The bone regeneration therapy is often used in patients with inadequate bone support for implants, particularly following tooth extractions. Xenografts derived from animal tissues are effective bone reconstructive options that resist resorption and pose a low risk of transmitting disease. Therefore, these implants may be a good option for enhancing and stabilizing maxillary sinuses. The purpose of this study was to compare two xenografts, Bone+B® and InterOss®, for the reconstruction of rabbit calvaria defects.

Methods and Materials

The study involved seven male New Zealand white rabbits. In the surgical procedure, 21 spots were created on both sides of the midline calvarium by creating three 8-millimeter defects. A control group was used, as well as two treatment groups utilizing Bone+B® Grafts and InterOss® Grafts. After 3 months, the rabbits were euthanized, followed by pathological evaluation. Analysis of these samples focused on bone formation, xenograft remaining material, and inflammation levels, using Adobe Photoshop CS 8.0 and SPSS version 24.

Results

With the application of Bone+B® graft, bone formation ranged from 32% to 45%, with a mean of 37.80% (±5.63), and the remaining material ranged from 28% to 37%, with a mean of 32.60% (±3.65). Using InterOss® grafts, bone formation was 61% to 75%, the mean was 65.83% (±4.75), and the remaining material was 9% to 18%, with a mean of 13.17% (±3.06). The bone formation in the control group ranged from 10% to 25%, with a mean of 17.17% (±6.11). InterOss® had lower inflammation levels than other groups, but the difference was not statistically significant (p > .05).

Conclusion

InterOss® bone powder is the best option for maxillofacial surgery and bone reconstruction. This is due to more bone formation, less remaining material, and a lower inflammation level. Compared to the control group, Bone+B® improves healing and bone quality, thus making it an alternative to InterOss®.

背景:骨再生疗法常用于种植体骨支持不足的患者,尤其是拔牙后的患者。从动物组织中提取的异种移植物是一种有效的骨重建选择,它能抵抗吸收,传播疾病的风险也很低。因此,这些种植体可能是增强和稳定上颌窦的良好选择。本研究的目的是比较 Bone+B® 和 InterOss® 两种异种移植物在兔腭窦缺损重建中的应用:这项研究涉及七只雄性新西兰白兔。在手术过程中,通过在小腿中线两侧创建三个 8 毫米的缺损,共创建了 21 个点。分为对照组以及使用 Bone+B® 人工骨和 InterOss® 人工骨的两个治疗组。3 个月后,兔子被安乐死,然后进行病理评估。使用 Adobe Photoshop CS 8.0 和 SPSS 24.0 版对这些样本进行分析,重点关注骨形成、异种移植剩余材料和炎症水平:使用 Bone+B® 移植物时,骨形成率为 32% 至 45%,平均值为 37.80%(±5.63),剩余材料率为 28% 至 37%,平均值为 32.60%(±3.65)。使用 InterOss® 移植物时,骨形成率为 61% 至 75%,平均为 65.83%(±4.75),剩余材料为 9% 至 18%,平均为 13.17%(±3.06)。对照组的骨形成率为 10%-25%,平均为 17.17%(±6.11)。InterOss®骨粉的炎症水平低于其他组,但差异无统计学意义(P > .05):结论:InterOss® 骨粉是颌面手术和骨重建的最佳选择。结论:InterOss® 骨粉是颌面手术和骨重建的最佳选择,因为它能形成更多的骨,减少剩余材料,降低炎症水平。与对照组相比,Bone+B® 可改善愈合和骨质,因此可作为 InterOss® 的替代品。
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引用次数: 0
A preliminary study on calcifying nanoparticles in dental plaque: Isolation, characterization, and potential mineralization mechanism 牙菌斑中钙化纳米粒子的初步研究:牙菌斑中钙化纳米粒子的初步研究:分离、表征和潜在矿化机制。
IF 1.8 Q3 Dentistry Pub Date : 2024-05-26 DOI: 10.1002/cre2.885
Siwei Wang, Lan Yang, Guohui Bai, Yu Gu, Qin Fan, Xiaoyan Guan, Jie Yuan, Jianguo Liu

Objectives

Calcifying nanoparticles (CNPs), referred to as nanobacteria (NB), are recognized to be associated with ectopic calcification. This study aims to isolate and culture CNPs from the dental plaque of patients with periodontal disease and investigate their possible role in unravelling the aetiology of periodontal disease.

Material and Methods

Supragingival and subgingival plaques were sampled from 30 periodontitis patients for CNPs isolation and culture. Alkaline phosphatase (ALP) content changes were tracked over time. Positive samples underwent thorough morphological identification via hematoxylin and eosin (HE) staining, Alizarin red S (ARS), and transmission electron microscopy (TEM). The chemical composition of CNPs analysis involved calcium (Ca) and phosphorus (P) content determination, Fourier transform infrared spectroscopy (FTIR), and X-ray diffraction (XRD).

Results

The subgingival plaque dental group exhibited a higher CNPs isolation rate at 36.67% (11/30) compared to the supragingival dental plaque group at 66.67% (20/30). ALP activity varied among the positive, negative and control groups. Morphological observation characterized the CNPs as round, oval, and ellipsoid particles with Ca deposits. Chemical analysis revealed the Ca/P ratio was 0.6753. Hydroxyl, methyl, carbonate, phosphate, hydrogen phosphate, and dihydrogen phosphate were detected by FTIR; the main chemical components detected by XRD were hydroxyapatite and tricalcium phosphate.

Conclusion

CNPs were found in periodontitis-related dental plaque and exhibited the potential to develop calcified structures resembling dental calculus. However, the potential involvement of ALP in CNPs formation requires deeper exploration, as does the precise nature of its role and the interrelation with periodontitis demand a further comprehensive investigation.

目的:钙化纳米颗粒(CNPs)被称为纳米细菌(NB),公认与异位钙化有关。本研究旨在从牙周病患者的牙菌斑中分离和培养 CNPs,并研究它们在揭示牙周病病因方面可能发挥的作用:材料和方法:从30名牙周炎患者的龈上和龈下牙菌斑中取样,进行CNPs的分离和培养。跟踪碱性磷酸酶(ALP)含量随时间的变化。通过苏木精和伊红(HE)染色、茜素红 S(ARS)和透射电子显微镜(TEM)对阳性样本进行彻底的形态鉴定。CNPs 的化学成分分析包括钙(Ca)和磷(P)含量测定、傅立叶变换红外光谱(FTIR)和 X 射线衍射(XRD):龈下牙菌斑组的 CNPs 分离率为 36.67%(11/30),而龈上牙菌斑组为 66.67%(20/30)。阳性组、阴性组和对照组的 ALP 活性各不相同。形态观察显示,CNPs 有圆形、椭圆形和椭圆形颗粒,并有钙沉积。化学分析显示,钙/磷比率为 0.6753。傅立叶变换红外光谱检测到羟基、甲基、碳酸盐、磷酸盐、磷酸氢盐和磷酸二氢盐;X射线衍射检测到的主要化学成分是羟基磷灰石和磷酸三钙:结论:在牙周炎相关牙菌斑中发现了 CNPs,并有可能形成类似牙结石的钙化结构。然而,ALP 可能参与了 CNPs 的形成,这需要更深入的探讨,其作用的确切性质以及与牙周炎的相互关系也需要进一步的全面研究。
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引用次数: 0
Comparing the efficacy of a novel mucoadhesive patch containing Nigella sativa 10% with triamcinolone 0.1% in patients with erosive-atrophic oral lichen planus: A pilot study 在侵蚀性-萎缩性口腔扁平苔藓患者中比较含有 10%黑升麻的新型粘液贴片与 0.1% 曲安奈德的疗效:试点研究。
IF 1.8 Q3 Dentistry Pub Date : 2024-05-26 DOI: 10.1002/cre2.886
Atessa Pakfetrat, Zahra Delavarian, Mahshid Malakooti, Hossein Bagheri, Habibollah Esmaily, Mahsa Ghorbani, Pooya Saeedi

Objective

This study evaluates the efficacy of a novel mucoadhesive patch containing Nigella sativa 10% extract compared to triamcinolone 0.1% in alleviating symptoms and reducing lesion severity in patients with erosive-atrophic oral lichen planus.

Methods and Materials

A pilot study comprising two groups, each with 10 patients, was conducted. The intervention group received mucoadhesive patches containing N. sativa 10% extract, while the control group received triamcinolone acetonide 0.1% patches. Pain and burning intensity, measured through visual analog scale, and lesion severity based on the Thongprasom scale were assessed weekly for 4 weeks. Descriptive records were kept for side effects and patient satisfaction.

Results

Pain and burning intensity decreased in both groups throughout the sessions, with the N. sativa group showing a greater reduction than the triamcinolone group. The reduction in burning intensity within each group was significant (p < .001), and there was a significant difference between groups only in the second session (p = .045). The overall difference between groups was not significant (p > .05). Lesion severity also decreased significantly in both groups (p < .001), with a significant difference between groups observed in the third session (p = .043) and overall throughout the study (p = .006).

Conclusion

The use of N. sativa extract in mucoadhesive patches was as effective as corticosteroids in reducing pain, burning, and lesion severity in patients with oral lichen planus, with N. sativa showing superior results in some sessions. Notably, no significant complications were observed with N. sativa use, making it a promising treatment option for lichen planus.

研究目的本研究评估了含有 10%黑升麻提取物的新型粘液贴片与 0.1% 曲安奈德相比,在缓解侵蚀性-萎缩性口腔扁平苔藓患者症状和降低皮损严重程度方面的疗效:试验研究包括两组,每组 10 名患者。干预组使用含 10%荠菜提取物的粘液贴片,对照组使用 0.1% 曲安奈德贴片。通过视觉模拟量表测量疼痛和烧灼感的强度,并根据 Thongprasom 量表评估病变的严重程度,每周评估一次,持续 4 周。对副作用和患者满意度进行描述性记录:结果:在整个疗程中,两组患者的疼痛和灼烧感都有所减轻,其中藜芦组的减轻幅度大于曲安奈德组。各组的灼烧强度均有显著降低(P .05)。两组的皮损严重程度也都明显减轻(p 结论:N.Sativa 提取物和三苯氧胺组的皮损严重程度都明显减轻:在减轻口腔扁平苔藓患者的疼痛、灼烧感和皮损严重程度方面,粘贴贴片中的荠菜提取物与皮质类固醇同样有效,而且在某些疗程中荠菜提取物的效果更好。值得注意的是,使用 N. sativa 没有观察到明显的并发症,使其成为治疗扁平苔藓的一种很有前景的选择。
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引用次数: 0
Optimizing esthetic zone periodontal regeneration in a 1–2-wall infrabony defect using recombinant human platelet-derived growth factor BB and β-tricalcium phosphate: A case report 使用重组人血小板衍生生长因子 BB 和 β-磷酸三钙优化 1-2 壁牙周缺损中的美学区牙周再生:病例报告。
IF 1.8 Q3 Dentistry Pub Date : 2024-05-26 DOI: 10.1002/cre2.908
Kantapon Rattanaprukskul, Rodrigo Neiva, Jonathan Korostoff

Objective

Periodontitis is an inflammatory condition induced by subgingival bacterial dysbiosis, resulting in inflammatory-mediated destruction of tooth-supporting structures, potentially leading to the formation of infrabony defects. This case report describes the treatment of a patient who presented with a combination 1–2-wall defect on tooth 21. To maintain the residual periodontal attachment and minimize esthetic consequences, a regenerative approach was performed using recombinant human platelet-derived growth factor-BB (rh-PDGF-BB) and β-tricalcium phosphate (β-TCP).

Materials and Methods

At the time of postscaling/root planing reevaluation, a 34-year-old Asian male initially diagnosed with molar/incisor pattern stage III grade C periodontitis exhibited a 6-mm residual probing depth on the mesiopalatal aspect of tooth 21. Periodontal regenerative surgery was performed using rh-PDGF-BB with β-TCP, without the use of a membrane.

Results

At the 1-year follow-up, a significant reduction in probing depth and radiographic evidence of bone fill were observed. Additionally, re-entry surgery for implant placement at site tooth 23 confirmed bone fill in the defect on tooth 21.

Conclusion

These results demonstrate the efficacy of rh-PDGF-BB with β-TCP in enhancing periodontal regeneration and support its use as a treatment option when treating poorly contained infrabony defects in the esthetic zone.

目的:牙周炎是由龈下细菌菌群失调引起的炎症,导致炎症介导的牙齿支持结构破坏,并可能形成牙槽骨下缺损。本病例报告描述了对一名 21 号牙 1-2 壁联合缺损患者的治疗。为了维持残余的牙周附着并尽量减少美观后果,我们使用重组人血小板衍生生长因子-BB(rh-PDGF-BB)和β-磷酸三钙(β-TCP)进行了再生治疗:一名 34 岁的亚裔男性在进行洗牙/根面平整术后复查时,初步诊断为臼齿/incisor 模式 III 期 C 级牙周炎,其第 21 号牙齿中腭侧的探诊深度残留 6 毫米。在不使用牙膜的情况下,使用 rh-PDGF-BB 和 β-TCP进行了牙周再生手术:随访 1 年后,探诊深度明显降低,X 光片显示骨填充。此外,在第 23 颗牙齿部位再次进行种植手术时,证实了第 21 颗牙齿缺损处的骨填充情况:这些结果表明,rh-PDGF-BB 和 β-TCP 能有效促进牙周再生,并支持将其作为治疗美观区内骨缺损的一种治疗方法。
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引用次数: 0
期刊
Clinical and Experimental Dental Research
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