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Artificial Intelligence And Precision Medicine For Oncology 肿瘤领域的人工智能和精准医学
Pub Date : 2020-04-02 DOI: 10.2139/ssrn.3566788
Ojaswini Singh, Rishabh Singh, Ankur Saxena
AI can help to essentially accelerate the process of analysis of vast amounts of data, anchoring patterns in the data, resulting in faster and recommended decision-making. Sophisticated prescient models are produced using algorithms that extract the patterns from data and predict results. AI is categorized into three stages namely, artificial narrow intelligence (ANI), artificial general intelligence(AGI), and artificial super intelligence(ASI). Precision medicine is a rising methodology for disease prevention and treatment based on the specific hereditary, environment conditions, and lifestyle choices of an individual patient. AI algorithms have been found to be compelling in streamlining malignant growth screening and discovery. AI frameworks are able to recognize singular drug-response variability, making recommendations based on patterns learned from vast amounts of public and exclusive information, and can help expand the frontier of precision medicine, specially of cancer genomics.
人工智能可以帮助加速对大量数据的分析过程,在数据中锚定模式,从而更快地做出建议性决策。复杂的先见之明模型是通过从数据中提取模式并预测结果的算法产生的。人工智能分为人工狭义智能(ANI)、人工通用智能(AGI)和人工超级智能(ASI)三个阶段。精准医学是一种新兴的疾病预防和治疗方法,基于特定的遗传、环境条件和个体患者的生活方式选择。人工智能算法已被发现在简化恶性生长筛选和发现方面具有引人注目的作用。人工智能框架能够识别单一的药物反应变异性,根据从大量公开和独家信息中学习到的模式提出建议,并有助于扩大精准医学的前沿,特别是癌症基因组学。
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引用次数: 1
Technological Change and Inequality in the Very Long Run 长期的技术变革和不平等
Pub Date : 2020-04-01 DOI: 10.2139/ssrn.3582603
J. Madsen, H. Strulik
In this paper we investigate the impact of technological change on inequalityin the presence of a landed elite using a standard unified growth model. We measure inequality by the ratio between land rent and wages and show that, before the onset of the fertility transition, technological progress increased inequality directly through land-biased technological change and indirectly through increasing population growth. Thefertility transition and the child quantity-quality trade-off eventually disabled the Malthusian mechanism, and technological progress triggered education and benefited workers. If the elasticity of substitution between land and labor is sufficiently high, the rent-wage ratio declines such that inequality is hump-shaped in the very long run. We use the publication of new farming book titles as a measure of technological progress in agriculture, and provide evidence for technology-driven inequality in Britain between 1525 and 1895. We confirm these results for a panel of European countries over the period 1265-1850 using agricultural productivity as a measure of technology. Finally, using patents in the period 1800-1980, we find a technology-driven inequality reversal around the onset of the fertility transition.
在本文中,我们使用一个标准的统一增长模型来研究技术变革对有地精英存在的不平等的影响。我们通过地租和工资之间的比率来衡量不平等,并表明,在生育率转变开始之前,技术进步通过土地倾斜的技术变革直接加剧了不平等,并通过人口增长间接加剧了不平等。生育率的转变和孩子数量-质量的权衡最终使马尔萨斯机制失效,而技术进步引发了教育并使工人受益。如果土地和劳动力之间的替代弹性足够高,租金-工资比率下降,使得不平等在很长一段时间内呈驼峰状。我们使用新农业书籍书名的出版作为农业技术进步的衡量标准,并为1525年至1895年间英国技术驱动的不平等提供证据。我们对1265年至1850年期间的欧洲国家面板进行了验证,使用农业生产率作为技术的衡量标准。最后,利用1800-1980年期间的专利数据,我们发现,在生育过渡开始前后,技术驱动的不平等出现了逆转。
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引用次数: 10
Range of web Crawling from HTTP Parse and HTML Requests as Static Digreph and Web Pages 从HTTP解析和HTML请求作为静态Digreph和网页的网络爬行范围
Pub Date : 2020-03-30 DOI: 10.2139/ssrn.3669657
Dr. Pradeep Ghantasala G S, VenkataSai Chinnam, Raju Karukuri, Sharath Sripad
This paper presents the Shark look calculation utilizing the refined form of PageRank calculation, "PageRank look" and Shark look, one of the primary energetic web look calculations. Shark search has a comprehensive database mapping system that makes it easy for users to customize online maps to suit their needs. Preparatory tests appear significant improvements over the initial calculation of page rank. Recently, the internet has grown a lot. By using different hypertext connections, users can find their tools. This Internet use led to web crawlers being invented. Web-based crawlers are full text search engines that support web browsers. Such web crawlers can be used for further study. For example, the broken information can be utilized in complex systems to discover lost connections, population identification. In this paper we discussed web crew members: their design, styles and different challenges when the Web crawlers are used by search engines.
本文利用PageRank计算的改进形式“PageRank look”和主要的高能网页外观计算之一的Shark look,提出了Shark look计算方法。Shark search有一个全面的数据库地图系统,用户可以很容易地定制在线地图来满足他们的需求。与初始页面排名计算相比,预备测试显示出显著的改进。最近,互联网发展迅速。通过使用不同的超文本连接,用户可以找到他们的工具。这种互联网的使用导致了网络爬虫的发明。基于web的爬虫是支持web浏览器的全文搜索引擎。这样的网络爬虫可以用于进一步的研究。例如,破碎的信息可以在复杂系统中用于发现丢失的连接,种群识别。在本文中,我们讨论了网络工作人员:他们的设计,风格和不同的挑战,当网络爬虫被搜索引擎使用。
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引用次数: 0
Comparative Analysis of Chatbots 聊天机器人的比较分析
Pub Date : 2020-03-29 DOI: 10.2139/ssrn.3563674
Shivang Verma, Lakshay Sahni, Moolchand Sharma
A chatbot is computer software that employs Natural Language Processing and Pattern Recognition techniques to provide appropriate answers to questions posed by humans. In this paper, we are analyzing and comparing the total accuracy score of the following chatbots: Rose, Google Assistant, Siri, Machine Comprehension Chatbot, Mitsuku, Jabberwacky, ALICE and Eliza based on the answers provided by them to a set of predefined questions. The chatbots were broadly analyzed on three focal parameters: 1. Assessment of Factual Questions, 2. Assessment of Conversational Attributes, and 3. Evaluation of Exceptional queries. The paper produces conclusive comparisons and conclusions and then ranks these chatbots according to their performance in the above-mentioned focal points. These focal points help in assessing the chatbots according to their responses by assigning a rank to each chatbot concerning others. The final level is evaluated by averaging grades attained in the three parameters above.
聊天机器人是一种计算机软件,它采用自然语言处理和模式识别技术,为人类提出的问题提供适当的答案。在本文中,我们基于以下聊天机器人:Rose、Google Assistant、Siri、Machine Comprehension Chatbot、Mitsuku、Jabberwacky、ALICE和Eliza提供的一组预定义问题的答案,对它们的总准确率进行了分析和比较。从三个焦点参数对聊天机器人进行了广泛的分析:事实性问题的评估,2。2 .会话属性评估;异常查询的评估。本文得出结论性的比较和结论,然后根据这些聊天机器人在上述焦点上的表现对它们进行排名。这些焦点通过为每个聊天机器人分配与其他人相关的等级来帮助根据它们的反应评估聊天机器人。最后的水平是通过上述三个参数的平均成绩来评估的。
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引用次数: 3
Is There Reliable Evidence of Biodegradable Metals Achieving Bone Fracture Repair in Animal Models: A Systematic Review 生物可降解金属在动物模型中实现骨折修复是否有可靠证据:系统综述
Pub Date : 2020-03-26 DOI: 10.2139/ssrn.3559931
Jiazhen Zhang, Zhizhong Shang, Yanbiao Jiang, Xing-gang Li, M. Ma, Yongjun Li, Bin Ma
Biodegradable metals hold promises in orthopedic applications such as fracture repair. Their clinical translation requires pre-clinical evaluations including animal studies, which demonstrate the safety and performance of such materials prior to clinical trials. This evidence-based study investigates and analyzes the performance of bone fractures repair as well as degradation properties of biodegradable metals in animal models. Data was carefully collected after identification of population, interventions, comparisons, outcomes, and study design (PICOS), as well as inclusion criteria combining biodegradable metals and animal study. 12 publications on pure Mg, Mg alloys and Zn alloys were finally included and reviewed after extraction from a collected database of 2122 publications. Compared to controls of traditional non-degradable metals or resorbable polymers, biodegradable metals showed mixed or contradictory outcomes of fracture repair and degradation in animal models. Although quantitative meta-analysis cannot be conducted because of the data heterogenicity, this systematic review revealed that the quality of evidence for biodegradable metals to repair bone fractures in animal models is "very low". Recommendations to standardize the animal studies of biodegradable metals were proposed. Based on current findings, there is no reliable evidence of bone fracture repair in animal models to ensure future clinical translation of biodegradable metals.
可生物降解金属在骨折修复等骨科应用中前景光明。它们的临床转化需要临床前评估,包括动物研究,在临床试验之前证明这些材料的安全性和性能。这项基于证据的研究调查和分析了动物模型中可生物降解金属的骨折修复性能和降解性能。在确定人群、干预措施、比较、结果和研究设计(PICOS)以及结合生物可降解金属和动物研究的纳入标准后,仔细收集数据。从2122篇文献数据库中提取纯Mg、Mg合金和Zn合金的文献12篇,并进行综述。与传统的不可降解金属或可吸收聚合物的对照组相比,生物可降解金属在动物模型中显示出混合或矛盾的骨折修复和降解结果。虽然由于数据的异质性无法进行定量荟萃分析,但本系统综述显示,生物可降解金属在动物模型中修复骨折的证据质量“非常低”。提出了规范生物可降解金属动物实验的建议。根据目前的研究结果,在动物模型中没有可靠的骨折修复证据来确保未来生物可降解金属的临床翻译。
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引用次数: 0
'Fundamental Criticism' of the White Paper and Data Strategy Paper of the EU Commission from 19 February 2020 对2020年2月19日欧盟委员会白皮书和数据战略文件的“基本批评”
Pub Date : 2020-03-17 DOI: 10.2139/ssrn.3675486
GOAL-Projekt Itm
On 19th February 2020, the European Commission published the long-awaited and pre-announced White Paper on artificial intelligence. In addition, the Commission published a document shaping Europe's digital future, a document on the European data strategy and a report on the impact of artificial intelligence, the Internet of Things and robotics on security and liability .

Commission President Ursula von der Leyen said in her presentation of the new EU digital strategy that the objectives for shaping Europe's digital future cover “everything from cyber-security to critical infrastructures, digital education to skills, democracy to media" . Whether this promise has been fulfilled and to what extent it has been possible to focus on content will be examined below. For this purpose, the following article will discuss individual proposals from selected documents and address newly emerging liability issues arising in connection with the use of AI.
2020年2月19日,欧盟委员会发布了期待已久的人工智能白皮书。此外,欧盟委员会还发布了一份塑造欧洲数字未来的文件,一份关于欧洲数据战略的文件,以及一份关于人工智能、物联网和机器人技术对安全和责任影响的报告。欧盟委员会主席乌苏拉·冯德莱恩在介绍新的欧盟数字战略时表示,塑造欧洲数字未来的目标涵盖“从网络安全到关键基础设施,从数字教育到技能,从民主到媒体”。这一承诺是否已经实现,以及在多大程度上可以关注内容,将在下文进行审查。为此,以下文章将讨论选定文件中的个别建议,并解决与使用人工智能有关的新出现的责任问题。
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引用次数: 0
New Infinite Series for Calculating the Circumference of an Ellipse 计算椭圆周长的新无穷级数
Pub Date : 2020-03-06 DOI: 10.2139/ssrn.3549861
Cetin Hakimoglu
In this paper a new formula for the circumference is derived which is faster than existing formulas and is based off of a cubic hypergeometric transformation.
本文在三次超几何变换的基础上,导出了一个比现有公式更快的周长计算公式。
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引用次数: 0
Quantification of the Influence of Thin Film Microstructure on Adhesion for a Model Brittle-Ductile Interface 薄膜微观结构对脆性-韧性模型界面附着力影响的定量分析
Pub Date : 2020-03-02 DOI: 10.2139/ssrn.3542921
A. Lassnig, V. L. Terziyska, J. Zalesak, T. Jörg, D. Többens, C. Mitterer, R. Pippan, M. Cordill
The influence of film microstructure on interface adhesion was studied on a model brittle-ductile interface consisting of thin Cu films on brittle glass substrates. Therefore, 110 nm thin Cu films were deposited on glass substrates using magnetron sputtering. While film thickness, residual stresses, and texture of the Cu films were maintained comparable in the sputtering processes, the film microstructure was varied during deposition and via isothermal annealing resulting in four different Cu films with bimodal grain size distributions. The interface adhesion of each Cu film was determined using stressed Mo overlayers, which triggered delamination of the Cu film from the glass substrates in the shape of straight spontaneous buckles. The model of Hutchinson and Suo for spontaneous buckles was applied to quantify the mixed mode adhesion energy for each film system ranging from 2.35 J/m² for the films with the highest amount of large grains to 4.90 J/m² for the films with the highest amount of nanosized grains. This surprising result could be clarified using an additional study of the buckles using focused ion beam cutting and quantification via confocal laser scanning microscopy to decouple and quantify the amount of elastic and plastic deformation stored in the buckled thin film. It could be shown that the films with smallest grains exhibit the possibility to absorb a higher amount of energy during delamination, which explains their improved adhesion.
在脆性玻璃基板上研究了由Cu薄膜组成的脆-韧界面模型,研究了薄膜微观结构对界面附着力的影响。因此,采用磁控溅射技术在玻璃衬底上沉积了110 nm的Cu薄膜。在溅射过程中,Cu薄膜的厚度、残余应力和织构保持相当,但在沉积和等温退火过程中,薄膜的微观结构发生了变化,导致四种不同的Cu薄膜具有双峰的晶粒尺寸分布。利用应力Mo包层测定了各Cu膜的界面附着力,这触发了Cu膜以直自发屈曲的形式从玻璃基板上分层。采用Hutchinson和Suo的自发屈曲模型,量化了各膜体系的混合模式粘附能,从大晶粒数量最多的膜的2.35 J/m²到纳米晶粒数量最多的膜的4.90 J/m²。这一惊人的结果可以通过使用聚焦离子束切割和通过共聚焦激光扫描显微镜对屈曲进行量化的额外研究来澄清,以解耦并量化屈曲薄膜中存储的弹性和塑性变形量。结果表明,颗粒最小的薄膜在分层过程中有可能吸收更多的能量,这就解释了其附着力的提高。
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引用次数: 0
Researches on the Influence of Geometric and Functional Parameters on the Flow Rate of a Rotating Machine with Profiled Rotors 几何参数和功能参数对异形转子旋转机械流量影响的研究
Pub Date : 2020-03-01 DOI: 10.38177/ajast.2020.4112
A. Almaslamani
The purpose of the paper is to find a solution to increase the fluid flow rate in a designed and built rotating machine. The increase of the flow rate can take place by modifying the following parameters: The geometrical parameters of the profiled rotors, The functional parameters of the machine, namely its speed. Constructive solutions of the machine that lead to the increase of the flow rate carried by it are presented; the influence of the speed of the machine on the flow rate is exposed, in the case of the analyzed constructive solutions.
本文的目的是找到一个解决方案,以提高流体流量的旋转机械设计和制造。可以通过修改以下参数来增加流量:异形转子的几何参数,机器的功能参数,即其转速。提出了导致其所载流量增大的构造解决方案;在分析构造解的情况下,揭示了机器转速对流量的影响。
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引用次数: 1
On Some Geometrical Properties of Proximal Sets and Existence of Best Proximity Points 关于邻近集的一些几何性质及最佳邻近点的存在性
Pub Date : 2020-03-01 DOI: 10.22377/AJMS.V4I1.253
Dr. S. Arul Ravi, A. Eldred
The notion of proximal intersection property and diagonal property is introduced and used to establish some existence of the best proximity point for mappings satisfying contractive conditions.
引入了近交性质和对角性质的概念,并利用它们建立了满足收缩条件的映射的最佳接近点的存在性。
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引用次数: 0
期刊
Other Topics Engineering Research eJournal
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