Pub Date : 2025-01-23DOI: 10.1016/j.compositesb.2025.112176
Yu Tian , Shuran Li , Weidong Zhu , Keping Yan , Yinglin Ke
This study explores the development of a tactile sensor utilizing reclaimed carbon fibers (rCFs) arranged as a biomimetic tilted microhair array (TMA), offering a sustainable approach to reduce carbon footprints and promote circular economy principles. The TMA-based sensor, inspired by the structure of animal fur, demonstrates notable sensitivity to both pressure and shear forces, key to replicating skin-like tactile sensing. Through an innovative fabrication process, rCFs were aligned and pressed into a tilted array on a flexible substrate, forming a highly ordered structure with anisotropic properties. The sensor exhibited a wide pressure detection range from 0.02 kPa to 13 kPa, with a maximum sensitivity of 24.00% kPa⁻1. Additionally, its response to shear forces reveals distinct anisotropic properties, enabling precise differentiation between axial and radial directions. The underlying sensing mechanism, driven by changes in intrinsic and contact resistance, was analyzed to elucidate the sensor's response to mechanical stimuli. Overall, the functionality of sensor is closely linked to its innovative use of rCFs, which addresses common challenges in recycling by transforming these fibers into a valuable sensing technology.
{"title":"Direct and simple upcycling of reclaimed carbon fiber into flexible tactile sensor with tilted microhair arrays","authors":"Yu Tian , Shuran Li , Weidong Zhu , Keping Yan , Yinglin Ke","doi":"10.1016/j.compositesb.2025.112176","DOIUrl":"10.1016/j.compositesb.2025.112176","url":null,"abstract":"<div><div>This study explores the development of a tactile sensor utilizing reclaimed carbon fibers (rCFs) arranged as a biomimetic tilted microhair array (TMA), offering a sustainable approach to reduce carbon footprints and promote circular economy principles. The TMA-based sensor, inspired by the structure of animal fur, demonstrates notable sensitivity to both pressure and shear forces, key to replicating skin-like tactile sensing. Through an innovative fabrication process, rCFs were aligned and pressed into a tilted array on a flexible substrate, forming a highly ordered structure with anisotropic properties. The sensor exhibited a wide pressure detection range from 0.02 kPa to 13 kPa, with a maximum sensitivity of 24.00% kPa⁻<sup>1</sup>. Additionally, its response to shear forces reveals distinct anisotropic properties, enabling precise differentiation between axial and radial directions. The underlying sensing mechanism, driven by changes in intrinsic and contact resistance, was analyzed to elucidate the sensor's response to mechanical stimuli. Overall, the functionality of sensor is closely linked to its innovative use of rCFs, which addresses common challenges in recycling by transforming these fibers into a valuable sensing technology.</div></div>","PeriodicalId":10660,"journal":{"name":"Composites Part B: Engineering","volume":"294 ","pages":"Article 112176"},"PeriodicalIF":12.7,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143169549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-22DOI: 10.1016/j.compositesb.2025.112168
Xiu-Zhen Zhang , Ya-Xing Li , Yan-Lin Jiang , Ming-Hui Fan , Long-Mei Zhao , Yun-Jin Bai , Chen-Yu Zou , Ji-Ye Zhang , Yu-Ting Song , Yue-Qi Zhang , Rui Wang , Wen-Qian Zhang , Qian-Jin Li , Jia-Wei Wang , Jesse Li-Ling , Hui-Qi Xie
Bladder reconstruction is one of the most challenging issues for urological surgery. Currently available scaffolds have limitations such as inefficient smooth muscle regeneration, graft contracture, and stone formation. Here, inspired by the native bladder, we have designed a functional universal sandwich biomimetic scaffold (PSP) with both repair effect and drug delivery system utilizing a membrane-hydrogel-membrane structure. The hydrogel and responsive microspheres acted as a dual-controlled release system for succinate (SA), an effective small molecule which can block the occurrence and growth of crystal. The double-sided membrane was made from a novel decellularized matrix-based procyanidin-crosslinked small intestine submucosa (PC–SIS) material, which has shown a great promise for bladder smooth muscle regeneration. While the luminal side of the membrane was modified with a femtosecond laser micro-machining system for the release of SA. In vitro assays showed that the scaffolds have superior biocompatibility and anti-calcification properties. Animal studies shown that the PSP scaffolds could facilitate early epithelial reconstruction and reduce the risk for stones by regulating immunological, osteogenic, and ion transport processes. Toward the end of treatment, the volume of regenerated bladder and compliance of the PSP group were much greater compared with those sandwich hydrogel. The multifunctional universal sandwich biomimetic scaffolds therefore can provide a promising strategy for the reconstruction of urinary bladders.
{"title":"A functional universal sandwich biomimetic scaffold with both repair effect and drug delivery system effectively facilitates bladder regeneration","authors":"Xiu-Zhen Zhang , Ya-Xing Li , Yan-Lin Jiang , Ming-Hui Fan , Long-Mei Zhao , Yun-Jin Bai , Chen-Yu Zou , Ji-Ye Zhang , Yu-Ting Song , Yue-Qi Zhang , Rui Wang , Wen-Qian Zhang , Qian-Jin Li , Jia-Wei Wang , Jesse Li-Ling , Hui-Qi Xie","doi":"10.1016/j.compositesb.2025.112168","DOIUrl":"10.1016/j.compositesb.2025.112168","url":null,"abstract":"<div><div>Bladder reconstruction is one of the most challenging issues for urological surgery. Currently available scaffolds have limitations such as inefficient smooth muscle regeneration, graft contracture, and stone formation. Here, inspired by the native bladder, we have designed a functional universal sandwich biomimetic scaffold (PSP) with both repair effect and drug delivery system utilizing a membrane-hydrogel-membrane structure. The hydrogel and responsive microspheres acted as a dual-controlled release system for succinate (SA), an effective small molecule which can block the occurrence and growth of crystal. The double-sided membrane was made from a novel decellularized matrix-based procyanidin-crosslinked small intestine submucosa (PC–SIS) material, which has shown a great promise for bladder smooth muscle regeneration. While the luminal side of the membrane was modified with a femtosecond laser micro-machining system for the release of SA. In vitro assays showed that the scaffolds have superior biocompatibility and anti-calcification properties. Animal studies shown that the PSP scaffolds could facilitate early epithelial reconstruction and reduce the risk for stones by regulating immunological, osteogenic, and ion transport processes. Toward the end of treatment, the volume of regenerated bladder and compliance of the PSP group were much greater compared with those sandwich hydrogel. The multifunctional universal sandwich biomimetic scaffolds therefore can provide a promising strategy for the reconstruction of urinary bladders.</div></div>","PeriodicalId":10660,"journal":{"name":"Composites Part B: Engineering","volume":"295 ","pages":"Article 112168"},"PeriodicalIF":12.7,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143102200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-22DOI: 10.1016/j.compositesb.2025.112165
Tianqi Wang , Xuan Fang , Hongqi Zhao , Yi Zhang , Yuanquan Li , Zhong Li , Wei Seong Toh , James HP. Hui , Jiyuan Yan
Chronic low back pain, typically managed through lumbar fusion, demands innovative approaches to enhance therapeutic outcomes. This study investigated the efficacy of small extracellular vesicles (sEVs) derived from bone marrow mesenchymal stem cells (BMSCs) cultured in three-dimensional (3D) scaffolds concurrently under electromagnetic fields (EMF) stimulation, aiming to enhance osteogenesis and angiogenesis in a rat lumbar fusion model. We utilized a composite of polycaprolactone (PCL) and hydroxyapatite (HA), engineered via 3D printing, to create the scaffolds. sEVs were harvested from BMSCs under three distinct conditions: standard 2D cultures, 3D scaffolds, and 3D scaffolds with EMF stimulation. Specifically, the sEVs from the EMF-stimulated 3D cultures (3D/E-sEVs) were incorporated into these scaffolds before being implanted into rat spines. Therapeutic effectiveness was evaluated in vitro through assays for cell proliferation, migration, and angiogenesis, and in vivo via X-ray imaging, micro-computed tomography (micro-CT), and histological analyses. Results revealed that 3D/E-sEVs markedly enhanced both osteogenesis and angiogenesis. Further mechanistic investigations identified the PTEN/PI3K/AKT signalling pathway as essential in mediating these regenerative effects. Moreover, 3D PCL/HA scaffold loaded with 3D/E-sEVs promote lumbar fusion in a rat model. Conclusively, our findings demonstrated that 3D-printed PCL/HA scaffolds engineered with 3D/E-sEVs significantly promoted bone regeneration and vascular formation, thereby improving lumbar fusion outcomes. This study highlights the profound potential of integrating advanced tissue engineering techniques with cellular therapies to revolutionize the treatment of chronic low back pain and enhance surgical success rates.
{"title":"Small extracellular vesicles from 3D PCL/HA scaffold-cultured and EMF-stimulated BMSCs promote lumbar fusion via PTEN/PI3K/AKT pathway","authors":"Tianqi Wang , Xuan Fang , Hongqi Zhao , Yi Zhang , Yuanquan Li , Zhong Li , Wei Seong Toh , James HP. Hui , Jiyuan Yan","doi":"10.1016/j.compositesb.2025.112165","DOIUrl":"10.1016/j.compositesb.2025.112165","url":null,"abstract":"<div><div>Chronic low back pain, typically managed through lumbar fusion, demands innovative approaches to enhance therapeutic outcomes. This study investigated the efficacy of small extracellular vesicles (sEVs) derived from bone marrow mesenchymal stem cells (BMSCs) cultured in three-dimensional (3D) scaffolds concurrently under electromagnetic fields (EMF) stimulation, aiming to enhance osteogenesis and angiogenesis in a rat lumbar fusion model. We utilized a composite of polycaprolactone (PCL) and hydroxyapatite (HA), engineered via 3D printing, to create the scaffolds. sEVs were harvested from BMSCs under three distinct conditions: standard 2D cultures, 3D scaffolds, and 3D scaffolds with EMF stimulation. Specifically, the sEVs from the EMF-stimulated 3D cultures (3D/E-sEVs) were incorporated into these scaffolds before being implanted into rat spines. Therapeutic effectiveness was evaluated <em>in vitro</em> through assays for cell proliferation, migration, and angiogenesis, and <em>in vivo</em> via X-ray imaging, micro-computed tomography (micro-CT), and histological analyses. Results revealed that 3D/E-sEVs markedly enhanced both osteogenesis and angiogenesis. Further mechanistic investigations identified the PTEN/PI3K/AKT signalling pathway as essential in mediating these regenerative effects. Moreover, 3D PCL/HA scaffold loaded with 3D/E-sEVs promote lumbar fusion in a rat model. Conclusively, our findings demonstrated that 3D-printed PCL/HA scaffolds engineered with 3D/E-sEVs significantly promoted bone regeneration and vascular formation, thereby improving lumbar fusion outcomes. This study highlights the profound potential of integrating advanced tissue engineering techniques with cellular therapies to revolutionize the treatment of chronic low back pain and enhance surgical success rates.</div></div>","PeriodicalId":10660,"journal":{"name":"Composites Part B: Engineering","volume":"294 ","pages":"Article 112165"},"PeriodicalIF":12.7,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143170021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-22DOI: 10.1016/j.compositesb.2025.112169
Hao Tu, Bolin Xie, Shuai Zhao, Fang Yao, Jian Wang
Zero-energy and environmentally favorable passive radiative cooling and heating (PRC/PRH) materials do not function satisfactorily under atmospheric back-radiation (cloudy, humid, reduced clarity) or for all-season building thermal management requirements. A biphasic honeycomb Janus foam (CF/HF) that exhibits superhydrophilic properties for cooling and superhydrophobic characteristics for heating is proposed to achieve superior radiative thermal management under various weather conditions. CF/HF exhibits an exceptionally rapid wicking time of 0.233 s, which facilitates straightforward, expedient, and efficient rehydration of the system. Concurrently, the honeycomb configuration of CF/HF enables efficient solar reflection (∼91%), and the intrinsic molecular oscillation within the PAAS + PDMS polymer chains aids in the dispersal of emitted heat through the atmospheric window (∼96.1%). Due to the combined cooling action, it is possible to attain a temperature reduction of 5.6 °C even under overcast conditions with an average solar irradiance of 410.7 W/m2. Furthermore, exceptional capabilities in both solar and electrothermal (joule) heating of the HF/CF foam serve as a potent supplementary strategy for the thermal management of buildings amidst unpredictable weather scenarios, especially in the extreme weather of icing, which is crucial for preserving the structural integrity of buildings and alleviating energy demands, among other benefits.
{"title":"Superhydrophilic cooling and superhydrophobic heating honeycomb Janus foam for all-weather thermal management in complex environments","authors":"Hao Tu, Bolin Xie, Shuai Zhao, Fang Yao, Jian Wang","doi":"10.1016/j.compositesb.2025.112169","DOIUrl":"10.1016/j.compositesb.2025.112169","url":null,"abstract":"<div><div>Zero-energy and environmentally favorable passive radiative cooling and heating (PRC/PRH) materials do not function satisfactorily under atmospheric back-radiation (cloudy, humid, reduced clarity) or for all-season building thermal management requirements. A biphasic honeycomb Janus foam (CF/HF) that exhibits superhydrophilic properties for cooling and superhydrophobic characteristics for heating is proposed to achieve superior radiative thermal management under various weather conditions. CF/HF exhibits an exceptionally rapid wicking time of 0.233 s, which facilitates straightforward, expedient, and efficient rehydration of the system. Concurrently, the honeycomb configuration of CF/HF enables efficient solar reflection (∼91%), and the intrinsic molecular oscillation within the PAAS + PDMS polymer chains aids in the dispersal of emitted heat through the atmospheric window (∼96.1%). Due to the combined cooling action, it is possible to attain a temperature reduction of 5.6 °C even under overcast conditions with an average solar irradiance of 410.7 W/m<sup>2</sup>. Furthermore, exceptional capabilities in both solar and electrothermal (joule) heating of the HF/CF foam serve as a potent supplementary strategy for the thermal management of buildings amidst unpredictable weather scenarios, especially in the extreme weather of icing, which is crucial for preserving the structural integrity of buildings and alleviating energy demands, among other benefits.</div></div>","PeriodicalId":10660,"journal":{"name":"Composites Part B: Engineering","volume":"294 ","pages":"Article 112169"},"PeriodicalIF":12.7,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143169551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-22DOI: 10.1016/j.compositesb.2025.112156
Joseph G. Kirchhoff , Nathaniel T. Heathman , Timothy Yap , Pratik Koirala , Tyler B. Hudson , Mehran Tehrani
In-situ consolidation automated fiber placement of thermoplastic composites (ICAT) offers a promising alternative to traditional manufacturing methods, potentially reducing both cost and energy consumption. This study investigates the interlaminar bonding of carbon fiber/low-melt Polyaryletherketone (CF/LM-PAEK) composites using four routes: (1) ICAT at slow speed, (2) ICAT at fast speed, (3) annealing after fast ICAT above the matrix's cold crystallization temperature, and (4) compression molding (CM) after fast ICAT above the matrix's melting temperature. Rapid cooling and crystal formation during ICAT hindered polymer chain interdiffusion, resulting in suboptimal interlaminar properties (mode I and II fracture toughness, and short beam shear). Annealing after fast ICAT reduced voids and cold crystallized the quenched amorphous regions, thereby producing behavior similar to that of slow ICAT. Meanwhile, CM significantly reduced voids, redistributed fibers, and—due to slow cooling from the melt—enhanced fiber-matrix adhesion, albeit rendering the matrix more brittle. In contrast, ICAT samples displayed a more ductile matrix behavior but poorer fiber-matrix adhesion, leading to comparable mode I values yet reduced mode II and short beam shear properties. This study also incorporates ultrasonic inspection, density measurements, X-ray micro-computed tomography (μCT), and cross-sectional microscopy to statistically analyze void content and morphology, and their effects of interlaminar properties. Ultimately, these findings offer new insights into the interplay between processing and bonding—a key factor in optimizing interlaminar properties in thermoplastic composites.
{"title":"Interlaminar bonding in thermoplastic composites: A comparative analysis of laser AFP and post-processing","authors":"Joseph G. Kirchhoff , Nathaniel T. Heathman , Timothy Yap , Pratik Koirala , Tyler B. Hudson , Mehran Tehrani","doi":"10.1016/j.compositesb.2025.112156","DOIUrl":"10.1016/j.compositesb.2025.112156","url":null,"abstract":"<div><div>In-situ consolidation automated fiber placement of thermoplastic composites (ICAT) offers a promising alternative to traditional manufacturing methods, potentially reducing both cost and energy consumption. This study investigates the interlaminar bonding of carbon fiber/low-melt Polyaryletherketone (CF/LM-PAEK) composites using four routes: (1) ICAT at slow speed, (2) ICAT at fast speed, (3) annealing after fast ICAT above the matrix's cold crystallization temperature, and (4) compression molding (CM) after fast ICAT above the matrix's melting temperature. Rapid cooling and crystal formation during ICAT hindered polymer chain interdiffusion, resulting in suboptimal interlaminar properties (mode I and II fracture toughness, and short beam shear). Annealing after fast ICAT reduced voids and cold crystallized the quenched amorphous regions, thereby producing behavior similar to that of slow ICAT. Meanwhile, CM significantly reduced voids, redistributed fibers, and—due to slow cooling from the melt—enhanced fiber-matrix adhesion, albeit rendering the matrix more brittle. In contrast, ICAT samples displayed a more ductile matrix behavior but poorer fiber-matrix adhesion, leading to comparable mode I values yet reduced mode II and short beam shear properties. This study also incorporates ultrasonic inspection, density measurements, X-ray micro-computed tomography (μCT), and cross-sectional microscopy to statistically analyze void content and morphology, and their effects of interlaminar properties. Ultimately, these findings offer new insights into the interplay between processing and bonding—a key factor in optimizing interlaminar properties in thermoplastic composites.</div></div>","PeriodicalId":10660,"journal":{"name":"Composites Part B: Engineering","volume":"294 ","pages":"Article 112156"},"PeriodicalIF":12.7,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143169030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-22DOI: 10.1016/j.compositesb.2025.112164
Jialin Bai , Zhuocheng Xie , Pengfei Zhang , Shichao Wang , Zehua Liu , Xiumin Yao , Xuejian Liu , Zhengren Huang
Ceramic–based electromagnetic wave (EMW) absorbing materials with lightweight characteristics and strong absorption properties can effectively reduce EMW pollution and interference. A simple technique for introducing wave–absorbing phases with multi–component and multi–microstructure in wave–transmitting ceramic matrices is essential for practical applications. Herein, porous SiCNnw/C/Si3N4 ceramics comprising a two–component absorbing phase with a heterogeneous interface and nanowire structure have been prepared via simple vacuum impregnation and heat treatment. Porous Si3N4 ceramics with low permittivity are used as the impedance matching matrix, while carbon layer and SiCN nanowires are used as wave loss phases. The heterogeneous interface between the carbon layer and Si3N4 and the nanowire structure of SiCN can enhance the polarization relaxation behavior and electron transport capacity in the material. The conversion of carbon into SiCN nanowires can be promoted by elevating the heat treatment temperature, which can effectively regulate the ratio of the two wave–absorbing phases, thus optimizing the impedance matching and realizing efficient EMW absorption. The prepared C1400/20 sample has a minimum reflection loss of −61.24 dB at a thickness of 2.77 mm and an effective absorption bandwidth (EAB) of 6.30 GHz at a thickness of 2.63 mm. The C1400/25 realizes an EAB of 5.61 GHz at a smaller thickness of 2.09 mm. Overall, this study provides new ideas for designing ceramic–based materials with excellent EMW absorption performance.
{"title":"Porous SiCNnw/C/Si3N4 ceramics with controlled component and structure for electromagnetic wave absorption","authors":"Jialin Bai , Zhuocheng Xie , Pengfei Zhang , Shichao Wang , Zehua Liu , Xiumin Yao , Xuejian Liu , Zhengren Huang","doi":"10.1016/j.compositesb.2025.112164","DOIUrl":"10.1016/j.compositesb.2025.112164","url":null,"abstract":"<div><div>Ceramic–based electromagnetic wave (EMW) absorbing materials with lightweight characteristics and strong absorption properties can effectively reduce EMW pollution and interference. A simple technique for introducing wave–absorbing phases with multi–component and multi–microstructure in wave–transmitting ceramic matrices is essential for practical applications. Herein, porous SiCN<sub>nw</sub>/C/Si<sub>3</sub>N<sub>4</sub> ceramics comprising a two–component absorbing phase with a heterogeneous interface and nanowire structure have been prepared via simple vacuum impregnation and heat treatment. Porous Si<sub>3</sub>N<sub>4</sub> ceramics with low permittivity are used as the impedance matching matrix, while carbon layer and SiCN nanowires are used as wave loss phases. The heterogeneous interface between the carbon layer and Si<sub>3</sub>N<sub>4</sub> and the nanowire structure of SiCN can enhance the polarization relaxation behavior and electron transport capacity in the material. The conversion of carbon into SiCN nanowires can be promoted by elevating the heat treatment temperature, which can effectively regulate the ratio of the two wave–absorbing phases, thus optimizing the impedance matching and realizing efficient EMW absorption. The prepared C1400/20 sample has a minimum reflection loss of −61.24 dB at a thickness of 2.77 mm and an effective absorption bandwidth (EAB) of 6.30 GHz at a thickness of 2.63 mm. The C1400/25 realizes an EAB of 5.61 GHz at a smaller thickness of 2.09 mm. Overall, this study provides new ideas for designing ceramic–based materials with excellent EMW absorption performance.</div></div>","PeriodicalId":10660,"journal":{"name":"Composites Part B: Engineering","volume":"294 ","pages":"Article 112164"},"PeriodicalIF":12.7,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143169546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-22DOI: 10.1016/j.compositesb.2025.112151
Hua Zhang , Yang Luo , Guanrong Li , Zeming Hu , Rong Xu , Tong Zhu , Xu Cao , Yudong Yao , Wei Jian , Jun Chen , Gordon G. Wallace , Jun Fu
Engineered tissues created through cell-laden hydrogel bioprinting offer a promising therapeutic approach for tissue regeneration. However, considerable challenges persist in the development of hydrogels that possess optimal gelling kinetics and viscoelastic properties, and sufficient stability to facilitate both the printing of biomimetic structures and the formation of engineered tissues. Herein, we present a rapidly gelling and long-term dynamic hyaluronate hydrogel achieved through the introduction of self-assembled F127 diacrylate (F127DA) micelles to modulate the kinetics of hydrazone crosslinking and the extent of dual-crosslinking network formation. The investigation demonstrates that the introduction of F127DA strengthens the interactions among the hyaluronate components, significantly accelerating gelation and increasing the mechanical stability of the optimal hydrogels. The rapidly formed ink permits low-shear mixing-injection printing, facilitating the construction of precise structures with high cell viability. The viscoelastic microenvironment fosters fibroblast spreading within the bioprinted matrices and supports the development of a biomimetic skin construct characterized by multilayer keratinocytes on the surface. Application of this dynamic hydrogel in a full-thickness mouse skin wound model accelerates tissue healing by inflammation suppression, angiogenesis and extracellular matrix promotion. This study demonstrates innovative modulation of gelation kinetics and viscoelasticity of dynamic hyaluronic hydrogels using block copolymer micelles for tissue engineering.
{"title":"Micelle-facilitated gelation kinetics and viscoelasticity of dynamic hyaluronan hydrogels for bioprinting of mimetic constructs and tissue repair","authors":"Hua Zhang , Yang Luo , Guanrong Li , Zeming Hu , Rong Xu , Tong Zhu , Xu Cao , Yudong Yao , Wei Jian , Jun Chen , Gordon G. Wallace , Jun Fu","doi":"10.1016/j.compositesb.2025.112151","DOIUrl":"10.1016/j.compositesb.2025.112151","url":null,"abstract":"<div><div>Engineered tissues created through cell-laden hydrogel bioprinting offer a promising therapeutic approach for tissue regeneration. However, considerable challenges persist in the development of hydrogels that possess optimal gelling kinetics and viscoelastic properties, and sufficient stability to facilitate both the printing of biomimetic structures and the formation of engineered tissues. Herein, we present a rapidly gelling and long-term dynamic hyaluronate hydrogel achieved through the introduction of self-assembled F127 diacrylate (F127DA) micelles to modulate the kinetics of hydrazone crosslinking and the extent of dual-crosslinking network formation. The investigation demonstrates that the introduction of F127DA strengthens the interactions among the hyaluronate components, significantly accelerating gelation and increasing the mechanical stability of the optimal hydrogels. The rapidly formed ink permits low-shear mixing-injection printing, facilitating the construction of precise structures with high cell viability. The viscoelastic microenvironment fosters fibroblast spreading within the bioprinted matrices and supports the development of a biomimetic skin construct characterized by multilayer keratinocytes on the surface. Application of this dynamic hydrogel in a full-thickness mouse skin wound model accelerates tissue healing by inflammation suppression, angiogenesis and extracellular matrix promotion. This study demonstrates innovative modulation of gelation kinetics and viscoelasticity of dynamic hyaluronic hydrogels using block copolymer micelles for tissue engineering.</div></div>","PeriodicalId":10660,"journal":{"name":"Composites Part B: Engineering","volume":"294 ","pages":"Article 112151"},"PeriodicalIF":12.7,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143170014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-22DOI: 10.1016/j.compositesb.2025.112174
Zhenghao Chen , Wangcheng Liu , Mustapha Boukhair , Muhammad Khusairy Bin Bakri , Hui Li , Shuangbao Zhang
The conflict between mechanical strength and toughness of polyhydroxybutyrate (PHB) based composites remains challenging for its advancing development and application. We report a straightforward and effective synergistic modification approach for preparing WF/PHB bio-composites with optimal multiple performances. Mixture design of experiments and characterizations were employed to investigate the positive synergistic effect of the poly(hydroxybutyrate-grafted-maleic anhydride) (PHB-g-MA) and poly(butylene succinate) (PBS) throughout the process of modification of the bio-composites. Three optimized formulations, the maximum strength formulation (MSF), the maximum toughness formulation (MTF), and the optimal formulation (OPTF) were selected based on the design criteria. Mechanistic analysis reveals that PHB-g-MA not only improves the interface compatibility between WF and the matrix but also promotes the uniformity dispersion of PBS toughener within the WF/PHB bio-composite. However, exceeding or imbalanced proportions of PHB-g-MA and PBS adversely affect the synergistic modification of multiple performances in the WF/PHB bio-composites. The OPTF yielded WF/PHB bio-composites with significantly improved mechanical properties, reflected in impact strength (+210.7 %), bending toughness (+165.6 %), and elongation at break (+110.8 %), along with gains in modulus of rupture (+25.6 %) and tensile strength (+22.4 %). Furthermore, compared to MSF and MTF, the OPTF effectively balances the conflict of enhancing strength and toughness while also exhibiting superior performance in processability, water resistance, dynamic elastic properties, and thermal stability. This work reveals the synergistic mechanism of PHB-g-MA and PBS modification in enhancing WF/PHB bio-composites, providing an easy and promising pathway for high-performance, eco-friendly, and sustainable WF/PHB bio-composite development.
{"title":"Engineering strong and tough wood fiber/polyhydroxybutyrate bio-composite: Synergistic modification, performance optimization, and mechanistic insights","authors":"Zhenghao Chen , Wangcheng Liu , Mustapha Boukhair , Muhammad Khusairy Bin Bakri , Hui Li , Shuangbao Zhang","doi":"10.1016/j.compositesb.2025.112174","DOIUrl":"10.1016/j.compositesb.2025.112174","url":null,"abstract":"<div><div>The conflict between mechanical strength and toughness of polyhydroxybutyrate (PHB) based composites remains challenging for its advancing development and application. We report a straightforward and effective synergistic modification approach for preparing WF/PHB bio-composites with optimal multiple performances. Mixture design of experiments and characterizations were employed to investigate the positive synergistic effect of the poly(hydroxybutyrate-grafted-maleic anhydride) (PHB-g-MA) and poly(butylene succinate) (PBS) throughout the process of modification of the bio-composites. Three optimized formulations, the maximum strength formulation (MSF), the maximum toughness formulation (MTF), and the optimal formulation (OPTF) were selected based on the design criteria. Mechanistic analysis reveals that PHB-g-MA not only improves the interface compatibility between WF and the matrix but also promotes the uniformity dispersion of PBS toughener within the WF/PHB bio-composite. However, exceeding or imbalanced proportions of PHB-g-MA and PBS adversely affect the synergistic modification of multiple performances in the WF/PHB bio-composites. The OPTF yielded WF/PHB bio-composites with significantly improved mechanical properties, reflected in impact strength (+210.7 %), bending toughness (+165.6 %), and elongation at break (+110.8 %), along with gains in modulus of rupture (+25.6 %) and tensile strength (+22.4 %). Furthermore, compared to MSF and MTF, the OPTF effectively balances the conflict of enhancing strength and toughness while also exhibiting superior performance in processability, water resistance, dynamic elastic properties, and thermal stability. This work reveals the synergistic mechanism of PHB-g-MA and PBS modification in enhancing WF/PHB bio-composites, providing an easy and promising pathway for high-performance, eco-friendly, and sustainable WF/PHB bio-composite development.</div></div>","PeriodicalId":10660,"journal":{"name":"Composites Part B: Engineering","volume":"295 ","pages":"Article 112174"},"PeriodicalIF":12.7,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143102199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The introduction of fiber-reinforced thermoplastic polymers in additive manufacturing has marked a significant turning point for this technology, offering the opportunity to extend its inherent flexibility to industrial sectors traditionally reliant on thermosetting composites. This innovation opens new applicative scenarios, such as the creation of more complex assemblies or the repair of damaged composite structures, where intricate-shape, functional 3D-printed parts can be implemented into pre-existing composite ones. Building on this premise, this experimental study explores design solutions for the fabrication of adhesive joints between dissimilar composite materials, specifically a polyamide-matrix composite reinforced with short carbon fibers (Onyx by Markforged), produced via Fused Deposition Modeling (FDM), and a thermoset Carbon Fiber Reinforced Polymer (CFRP) laminate, fabricated through vacuum-assisted resin infusion technique. Two sets of joints – each comprising six joint series configured according to both single overlap and more complex (''multi-layer'') geometries – are evaluated in parallel, employing two commercial adhesives (acrylic and epoxy), and specific surface-preparation procedures (solvent cleaning, abrasion, or low-pressure plasma), tailored to the substrate-adhesive combination. A comparison between the cases is proposed based on the results of tensile shear tests, focusing on the mechanical and failure behavior of the joints as a function of the geometry and the adhesive system used, as well as on process-related aspects and application implications.
{"title":"Adhesive bonding of CFRP with a 3D-printed short-fiber composite: An experimental study on the effects of geometry and adhesive system on joint performance","authors":"Marco Pizzorni , Matteo Benvenuto , Enrico Lertora , Chiara Mandolfino","doi":"10.1016/j.compositesb.2025.112155","DOIUrl":"10.1016/j.compositesb.2025.112155","url":null,"abstract":"<div><div>The introduction of fiber-reinforced thermoplastic polymers in additive manufacturing has marked a significant turning point for this technology, offering the opportunity to extend its inherent flexibility to industrial sectors traditionally reliant on thermosetting composites. This innovation opens new applicative scenarios, such as the creation of more complex assemblies or the repair of damaged composite structures, where intricate-shape, functional 3D-printed parts can be implemented into pre-existing composite ones. Building on this premise, this experimental study explores design solutions for the fabrication of adhesive joints between dissimilar composite materials, specifically a polyamide-matrix composite reinforced with short carbon fibers (Onyx by Markforged), produced via Fused Deposition Modeling (FDM), and a thermoset Carbon Fiber Reinforced Polymer (CFRP) laminate, fabricated through vacuum-assisted resin infusion technique. Two sets of joints – each comprising six joint series configured according to both single overlap and more complex (''multi-layer'') geometries – are evaluated in parallel, employing two commercial adhesives (acrylic and epoxy), and specific surface-preparation procedures (solvent cleaning, abrasion, or low-pressure plasma), tailored to the substrate-adhesive combination. A comparison between the cases is proposed based on the results of tensile shear tests, focusing on the mechanical and failure behavior of the joints as a function of the geometry and the adhesive system used, as well as on process-related aspects and application implications.</div></div>","PeriodicalId":10660,"journal":{"name":"Composites Part B: Engineering","volume":"294 ","pages":"Article 112155"},"PeriodicalIF":12.7,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143169547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-21DOI: 10.1016/j.compositesb.2025.112161
Chengyuan Liu , Huan Wang , Ye Gu , Zhangqin Yuan , Qifan Yu , Changjiang Liu , Han Sun , Yuanchen Zhu , Qianping Guo , Caihong Zhu , Bin Li
Bone tissue engineering through regulation of mesenchymal stem cells (MSCs) provides a promising strategy for bone repair via intramembranous or endochondral ossification. Here, the novel approach of promoting the transformation of MSCs into osteo-chondroprogenitors to simulate the initial process in bone development to improve bone repair was proposed and validated via the use of a small-molecule drug, kartogenin (KGN). The transformation of MSCs into osteo-chondroprogenitors was effectively achieved by KGN treatment in 1 week. In the Ca2+-rich bone microenvironment in vitro, the transformation of MSCs markedly enhanced osteoblast generation by upregulating SOX9, RUNX2, and β-catenin. In vivo experiments further verified that the transformation of osteo-chondroprogenitors drove rapid bone repair within 4 weeks, through both intramembranous and endochondral ossification. This study proposes accelerating bone regeneration by inducing the transformation of MSCs into osteo-chondroprogenitors and reveals the co-existence of intramembranous and endochondral ossification during bone repair, providing new insights for bone regeneration.
{"title":"Kartogenin-mediated transformation of osteo-chondroprogenitors from stem cells facilitates bone repair via intramembranous and endochondral ossification","authors":"Chengyuan Liu , Huan Wang , Ye Gu , Zhangqin Yuan , Qifan Yu , Changjiang Liu , Han Sun , Yuanchen Zhu , Qianping Guo , Caihong Zhu , Bin Li","doi":"10.1016/j.compositesb.2025.112161","DOIUrl":"10.1016/j.compositesb.2025.112161","url":null,"abstract":"<div><div>Bone tissue engineering through regulation of mesenchymal stem cells (MSCs) provides a promising strategy for bone repair via intramembranous or endochondral ossification. Here, the novel approach of promoting the transformation of MSCs into osteo-chondroprogenitors to simulate the initial process in bone development to improve bone repair was proposed and validated via the use of a small-molecule drug, kartogenin (KGN). The transformation of MSCs into osteo-chondroprogenitors was effectively achieved by KGN treatment in 1 week. In the Ca<sup>2+</sup>-rich bone microenvironment in vitro, the transformation of MSCs markedly enhanced osteoblast generation by upregulating SOX9, RUNX2, and β-catenin. In vivo experiments further verified that the transformation of osteo-chondroprogenitors drove rapid bone repair within 4 weeks, through both intramembranous and endochondral ossification. This study proposes accelerating bone regeneration by inducing the transformation of MSCs into osteo-chondroprogenitors and reveals the co-existence of intramembranous and endochondral ossification during bone repair, providing new insights for bone regeneration.</div></div>","PeriodicalId":10660,"journal":{"name":"Composites Part B: Engineering","volume":"294 ","pages":"Article 112161"},"PeriodicalIF":12.7,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143169554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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