Pub Date : 2024-04-04DOI: 10.2174/0115734110295420240314052821
Maroj Bharati, Vikram Singh, Ram Kripal
Background: The zero-field splitting parameters of Mn2+ doped L-histidine-4- nitrophenolate 4-nitrophenol single crystals are evaluated Methods: The superposition model and perturbation theory are used to obtain zero-field splitting parameters for Mn2+ ion-doped LHPP single crystals. The optical spectra of the system are computed using the crystal field parameters from the superposition model as input into the crystal field analysis program. Results: The evaluated zero field splitting parameters are in good match with the experimental values when local distortion is taken into account. The experimental finding that the Mn2+ ion enters the L-histidine-4-nitrophenolate 4-nitrophenol lattice at the interstitial position is supported by the theoretical result. Conclusion: It is found that the calculated and experimental band positions agree fairly well. Thus, the theoretical study supports the experimental observation.
背景：评估掺杂 Mn2+ 离子的 L 组氨酸-4-硝基酚单晶的零场分裂参数：利用叠加模型和扰动理论获得掺杂 Mn2+离子的 LHPP 单晶的零场分裂参数。将叠加模型中的晶体场参数输入晶体场分析程序，计算出系统的光学光谱。结果：在考虑了局部畸变的情况下，所评估的零场分裂参数与实验值非常吻合。Mn2+ 离子在间隙位置进入 L 组氨酸-4-硝基苯酚-4-硝基酚晶格的实验结果得到了理论结果的支持。结论研究发现，计算带位置与实验带位置相当吻合。因此，理论研究支持了实验观察结果。
{"title":"Local Structure and Optical Studies of Mn2+ Doped L-histidine-4-nitrophenolate 4-nitrophenol Single Crystal","authors":"Maroj Bharati, Vikram Singh, Ram Kripal","doi":"10.2174/0115734110295420240314052821","DOIUrl":"https://doi.org/10.2174/0115734110295420240314052821","url":null,"abstract":"Background: The zero-field splitting parameters of Mn2+ doped L-histidine-4- nitrophenolate 4-nitrophenol single crystals are evaluated Methods: The superposition model and perturbation theory are used to obtain zero-field splitting parameters for Mn2+ ion-doped LHPP single crystals. The optical spectra of the system are computed using the crystal field parameters from the superposition model as input into the crystal field analysis program. Results: The evaluated zero field splitting parameters are in good match with the experimental values when local distortion is taken into account. The experimental finding that the Mn2+ ion enters the L-histidine-4-nitrophenolate 4-nitrophenol lattice at the interstitial position is supported by the theoretical result. Conclusion: It is found that the calculated and experimental band positions agree fairly well. Thus, the theoretical study supports the experimental observation.","PeriodicalId":10742,"journal":{"name":"Current Analytical Chemistry","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140561711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-28DOI: 10.2174/0115734110293837240320042928
Feng Yin, Diana Adhikari, Xiaodong F. Liu, Jianxin Wang, Wensheng Yang, Gabriela A. Balogh, Teri Simon, Wenji Lei, Mariana Squicciarini, Lisa Bruce, Yan Ke, Mike Dyszel, Shawn Harriman, Jan Pinkas
Background:: PYX-106 is a novel monoclonal antibody (mAb), targeting the sialic acidbinding immunoglobulin-like lectin 15 (Siglec-15) in the Tumor Microenvironment (TME). Precise measurement of PYX-106 is essential for the thorough assessment of PYX-106 pharmacokinetics in clinical investigations. Methods:: A novel Electrochemiluminescence (ECL) immunoassay for the quantitation of PYX- 106 in human serum was developed and validated. Biotinylated anti-PYX-106 antibody Bio-A1A1 was employed as the capture antibody, and ruthenylated anti-PYX-106 antibody Ru-A3G10 was utilized as the detection antibody in the ECL immunoassay on Meso Scale Discovery (MSD) platform. Results:: This assay was fully validated in terms of selectivity, accuracy, precision, hook effect, stability, etc., with a dynamic range from 50.0 to 2,500 ng/mL in human serum under the 2018 U.S. Food and Drug Administration (FDA) guidance and the 2022 U.S. FDA ICH M10 guidance. Conclusion:: PYX-106 bioanalytical assay validation was reported for the first time in a biological matrix, and this assay has been successfully applied to support a clinical trial PYX-106-101.
背景PYX-106是一种新型单克隆抗体（mAb），其靶点是肿瘤微环境（TME）中的硅铝酸结合免疫球蛋白样凝集素15（Siglec-15）。PYX-106的精确测量对于在临床研究中全面评估PYX-106的药代动力学至关重要。方法开发并验证了一种新型电化学发光（ECL）免疫测定法，用于定量检测人血清中的PYX- 106。采用生物素化的抗PYX-106抗体Bio-A1A1作为捕获抗体，以钌化的抗PYX-106抗体Ru-A3G10作为检测抗体，在中观尺度发现（MSD）平台上进行ECL免疫测定。结果根据2018年美国食品药品管理局（FDA）指南和2022年美国FDA ICH M10指南，该检测方法在选择性、准确性、精密度、钩效应、稳定性等方面得到了充分验证，在人血清中的动态范围为50.0至2,500 ng/mL。结论：：首次报道了PYX-106在生物基质中的生物分析测定验证，该测定已成功应用于支持临床试验PYX-106-101。
{"title":"A Novel Electrochemiluminescence (ECL) Immunoassay for the Quantitation of Monoclonal Antibody (mAb) PYX-106 in Human Serum","authors":"Feng Yin, Diana Adhikari, Xiaodong F. Liu, Jianxin Wang, Wensheng Yang, Gabriela A. Balogh, Teri Simon, Wenji Lei, Mariana Squicciarini, Lisa Bruce, Yan Ke, Mike Dyszel, Shawn Harriman, Jan Pinkas","doi":"10.2174/0115734110293837240320042928","DOIUrl":"https://doi.org/10.2174/0115734110293837240320042928","url":null,"abstract":"Background:: PYX-106 is a novel monoclonal antibody (mAb), targeting the sialic acidbinding immunoglobulin-like lectin 15 (Siglec-15) in the Tumor Microenvironment (TME). Precise measurement of PYX-106 is essential for the thorough assessment of PYX-106 pharmacokinetics in clinical investigations. Methods:: A novel Electrochemiluminescence (ECL) immunoassay for the quantitation of PYX- 106 in human serum was developed and validated. Biotinylated anti-PYX-106 antibody Bio-A1A1 was employed as the capture antibody, and ruthenylated anti-PYX-106 antibody Ru-A3G10 was utilized as the detection antibody in the ECL immunoassay on Meso Scale Discovery (MSD) platform. Results:: This assay was fully validated in terms of selectivity, accuracy, precision, hook effect, stability, etc., with a dynamic range from 50.0 to 2,500 ng/mL in human serum under the 2018 U.S. Food and Drug Administration (FDA) guidance and the 2022 U.S. FDA ICH M10 guidance. Conclusion:: PYX-106 bioanalytical assay validation was reported for the first time in a biological matrix, and this assay has been successfully applied to support a clinical trial PYX-106-101.","PeriodicalId":10742,"journal":{"name":"Current Analytical Chemistry","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140324804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-28DOI: 10.2174/0115734110286586240222100116
Naman Deep Raj, Dilpreet Singh
Introduction:: A simple, precise, and sensitive UV spectrophotometric method was developed to estimate Imipramine and Ferulic acid in bulk and polymeric micelles formulation. Moreover, imipramine and ferulic acid showed maximum absorbance at 237 nm and 216 nm. Method:: The method was validated for linearity, accuracy, precision, robustness, and ruggedness. The detector response for the imipramine and ferulic acid was linear over the selected range of 2 to 12 μg/ml with a correlation coefficient of 0.996 and 0.997. The accuracy was 99.4 and 101.02%. The precision (RSD) among six sample preparations was 0.68% and 0.85%. The method was validated as per the ICH guidelines. A polymeric micelle formulation was developed containing Vitamin E TPGS and F-127 as a surfactant and block co-polymer using different solvents. The optimized formulation containing 40 mg of F-127 and 30 mg of TPGS yielded the desired attributes of the optimized formulation. Result:: The optimized formulation was subjected to freeze-drying and yielded nanoparticulate size and excellent flowability. In vitro, the release of both drugs from the polymeric micelles was evaluated using dissolution, and multi-fold enhancement in release behavior was demonstrated compared to pure drugs. Both drugs were simultaneously detected successfully with accuracy and precision in bulk form and during in vitro analysis Conclusion:: The developed method can be adopted in routine analysis of imipramine and ferulic acid in bulk, and it involves relatively low-cost solvents with no complex extraction techniques.
{"title":"Development of UV Method for Simultaneous Estimation of Imipramine and Ferulic Acid in Bulk and Developed Freeze-Dried Mixed Micelles","authors":"Naman Deep Raj, Dilpreet Singh","doi":"10.2174/0115734110286586240222100116","DOIUrl":"https://doi.org/10.2174/0115734110286586240222100116","url":null,"abstract":"Introduction:: A simple, precise, and sensitive UV spectrophotometric method was developed to estimate Imipramine and Ferulic acid in bulk and polymeric micelles formulation. Moreover, imipramine and ferulic acid showed maximum absorbance at 237 nm and 216 nm. Method:: The method was validated for linearity, accuracy, precision, robustness, and ruggedness. The detector response for the imipramine and ferulic acid was linear over the selected range of 2 to 12 μg/ml with a correlation coefficient of 0.996 and 0.997. The accuracy was 99.4 and 101.02%. The precision (RSD) among six sample preparations was 0.68% and 0.85%. The method was validated as per the ICH guidelines. A polymeric micelle formulation was developed containing Vitamin E TPGS and F-127 as a surfactant and block co-polymer using different solvents. The optimized formulation containing 40 mg of F-127 and 30 mg of TPGS yielded the desired attributes of the optimized formulation. Result:: The optimized formulation was subjected to freeze-drying and yielded nanoparticulate size and excellent flowability. In vitro, the release of both drugs from the polymeric micelles was evaluated using dissolution, and multi-fold enhancement in release behavior was demonstrated compared to pure drugs. Both drugs were simultaneously detected successfully with accuracy and precision in bulk form and during in vitro analysis Conclusion:: The developed method can be adopted in routine analysis of imipramine and ferulic acid in bulk, and it involves relatively low-cost solvents with no complex extraction techniques.","PeriodicalId":10742,"journal":{"name":"Current Analytical Chemistry","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140324916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-28DOI: 10.2174/0115734110294187240315082239
A. Kumaravel, S. Aishwarya, S. Sathiyamoorthi
: The use of organophosphate pesticides (OPPs) in agricultural practices improves crop yield and controls pests, but their indiscriminate use and persistence in the environment pose significant health risks. Therefore, it has become increasingly important to develop reliable and efficient detection methods for OPPs to ensure food safety and monitor their presence. In recent years, OPP detection methods have undergone significant advancements. Sensors such as colorimetric, fluorescence, electrochemical, and impedometric offer several advantages over traditional methods, such as high sensitivity, selectivity, and portability. The purpose of this review paper is to provide an overview of recent developments in OPP detection methods. The paper discusses the different types of sensors that are available for the detection of OPPs, as well as their advantages and disadvantages. Many electrochemical methods have been employed to investigate OPP detection, including voltammetry, impedance spectroscopy, and amperometry. The integration of nanomaterials, such as carbon nanotubes, graphene, and metal nanoparticles, has significantly enhanced the performance of electrochemical sensors by providing high surface area, enhanced electron transfer, and specific analyte interactions. Furthermore, the review discusses the utilization of biomolecules, such as enzymes and aptamers, as recognition elements in sensor platforms for selective and sensitive OPP detection. The incorporation of these biomolecules offers high specificity and enables real-time monitoring of OPP residues in food samples and environmental matrices. It emphasizes the importance of continued research and development to optimize detection methods, improve sensor performance, and make these technologies more widely accessible for effective monitoring and control of OPP contamination in various domains.
:在农业实践中使用有机磷农药（OPPs）可提高作物产量并控制害虫，但其滥用和在环境中的持久性对健康构成了重大风险。因此，开发可靠有效的 OPPs 检测方法以确保食品安全和监测其存在变得越来越重要。近年来，OPP 检测方法取得了重大进展。与传统方法相比，比色法、荧光法、电化学法和阻抗法等传感器具有灵敏度高、选择性强和便于携带等优点。本文旨在概述 OPP 检测方法的最新进展。本文讨论了可用于检测 OPP 的不同类型传感器及其优缺点。研究 OPP 检测的电化学方法有很多，包括伏安法、阻抗光谱法和安培法。纳米材料（如碳纳米管、石墨烯和金属纳米颗粒）通过提供高表面积、增强电子传递和特定分析物相互作用，大大提高了电化学传感器的性能。此外，该综述还讨论了在传感器平台中利用酶和适配体等生物大分子作为识别元件，进行选择性和灵敏度 OPP 检测的问题。这些生物大分子的加入具有高度特异性，可对食品样品和环境基质中的 OPP 残留进行实时监测。报告强调了继续研究和开发的重要性，以优化检测方法，提高传感器性能，并使这些技术更广泛地用于有效监测和控制各领域的 OPP 污染。
{"title":"Emerging Technologies for Sensitive Detection of Organophosphate Pesticides: A Review","authors":"A. Kumaravel, S. Aishwarya, S. Sathiyamoorthi","doi":"10.2174/0115734110294187240315082239","DOIUrl":"https://doi.org/10.2174/0115734110294187240315082239","url":null,"abstract":": The use of organophosphate pesticides (OPPs) in agricultural practices improves crop yield and controls pests, but their indiscriminate use and persistence in the environment pose significant health risks. Therefore, it has become increasingly important to develop reliable and efficient detection methods for OPPs to ensure food safety and monitor their presence. In recent years, OPP detection methods have undergone significant advancements. Sensors such as colorimetric, fluorescence, electrochemical, and impedometric offer several advantages over traditional methods, such as high sensitivity, selectivity, and portability. The purpose of this review paper is to provide an overview of recent developments in OPP detection methods. The paper discusses the different types of sensors that are available for the detection of OPPs, as well as their advantages and disadvantages. Many electrochemical methods have been employed to investigate OPP detection, including voltammetry, impedance spectroscopy, and amperometry. The integration of nanomaterials, such as carbon nanotubes, graphene, and metal nanoparticles, has significantly enhanced the performance of electrochemical sensors by providing high surface area, enhanced electron transfer, and specific analyte interactions. Furthermore, the review discusses the utilization of biomolecules, such as enzymes and aptamers, as recognition elements in sensor platforms for selective and sensitive OPP detection. The incorporation of these biomolecules offers high specificity and enables real-time monitoring of OPP residues in food samples and environmental matrices. It emphasizes the importance of continued research and development to optimize detection methods, improve sensor performance, and make these technologies more widely accessible for effective monitoring and control of OPP contamination in various domains.","PeriodicalId":10742,"journal":{"name":"Current Analytical Chemistry","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140324780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-26DOI: 10.2174/0115734110298095240320083449
Aiany Maria Queiroz Felix, S. Alves Júnior, A. G. S. Silva Júnior, Michelly Cristiny Pereira, Maria Danielly Lima Oliveira, César Augusto Souza de Andrade
Lung carcinoma presents an aggressive evolution, with its carriers having reduced survival. Late diagnosis is one of the main factors of death. In the neoplasia in question, there is an established correlation with increases in Alpha-Fetoprotein (AFP) serum concentrations. Commonly used diagnostic methods are invasive or inaccessible. Therefore, a low-cost, non-invasive method would be extremely promising, and biomarkers can be used to achieve this goal. Electrochemical biosensors are a promising approach for detecting analytes of clinical interest using innovative bioreceptors. In this work, we obtained an electrochemical biosensor based on a hybrid ligand metal-organic structure (ZIF-8-905%) and functionalized carbon nanotubes (MWCNTs- COOH) in association with the lectin Concanavalin A (ConA), as a biorecognition element for detecting AFP in human serum from patients with lung carcinoma. Cyclic Voltammetry (CV), Square Wave Voltammetry (SWV), and Electrochemical Impedance Spectroscopy (EIS) were used to characterize the development of this biosensor. Microscopic analysis through Atomic Force Microscopy (AFM) revealed the formation of ConA-AFP complexes, pointing out the sensor's ability to identify the target analyte. The blocking electron transfer effect in the electrode-redox pair interface assessed AFP detection. The ZIF-8-905%/MWCNTs-COOH/ConA platform exhibited a limit of detection (LOD) of 7.98 ng/mL, and a limit of quantification (LOQ) of 23.78ng/mL was also estimated. In addition, the biosensor showed excellent selectivity towards interfering biomolecules. Therefore, the biosensor represents an efficient form of detection, contributing to research that aims to detect tumor biomarkers and ensure better prognoses.
{"title":"Biosensor Based on Zif-8-905% Metal-organic Nanocomposite and\u0000Carbon Nanotubes Associated with Concanavalin a for Detection of\u0000Alpha-fetoprotein","authors":"Aiany Maria Queiroz Felix, S. Alves Júnior, A. G. S. Silva Júnior, Michelly Cristiny Pereira, Maria Danielly Lima Oliveira, César Augusto Souza de Andrade","doi":"10.2174/0115734110298095240320083449","DOIUrl":"https://doi.org/10.2174/0115734110298095240320083449","url":null,"abstract":"\u0000\u0000Lung carcinoma presents an aggressive evolution, with its carriers having\u0000reduced survival. Late diagnosis is one of the main factors of death. In the neoplasia in question,\u0000there is an established correlation with increases in Alpha-Fetoprotein (AFP) serum concentrations.\u0000\u0000\u0000\u0000Commonly used diagnostic methods are invasive or inaccessible. Therefore, a low-cost,\u0000non-invasive method would be extremely promising, and biomarkers can be used to achieve this\u0000goal. Electrochemical biosensors are a promising approach for detecting analytes of clinical interest\u0000using innovative bioreceptors. In this work, we obtained an electrochemical biosensor based on a\u0000hybrid ligand metal-organic structure (ZIF-8-905%) and functionalized carbon nanotubes (MWCNTs-\u0000COOH) in association with the lectin Concanavalin A (ConA), as a biorecognition element for detecting\u0000AFP in human serum from patients with lung carcinoma. Cyclic Voltammetry (CV), Square\u0000Wave Voltammetry (SWV), and Electrochemical Impedance Spectroscopy (EIS) were used to characterize\u0000the development of this biosensor. Microscopic analysis through Atomic Force Microscopy\u0000(AFM) revealed the formation of ConA-AFP complexes, pointing out the sensor's ability to identify\u0000the target analyte.\u0000\u0000\u0000\u0000The blocking electron transfer effect in the electrode-redox pair interface assessed AFP detection.\u0000The ZIF-8-905%/MWCNTs-COOH/ConA platform exhibited a limit of detection (LOD) of\u00007.98 ng/mL, and a limit of quantification (LOQ) of 23.78ng/mL was also estimated. In addition, the\u0000biosensor showed excellent selectivity towards interfering biomolecules.\u0000\u0000\u0000\u0000Therefore, the biosensor represents an efficient form of detection, contributing to research\u0000that aims to detect tumor biomarkers and ensure better prognoses.\u0000","PeriodicalId":10742,"journal":{"name":"Current Analytical Chemistry","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140378554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-26DOI: 10.2174/0115734110286724240318051113
Akshay Verma, Gaurav Sharma, Amit Kumar, Pooja Dhiman, F. J. Stadler
: Biochar has garnered considerable attention in recent times due to its potential uses in the environmental field. In this study, we comprehensively examine and condense information on biochar production, characteristics, and adsorption mechanisms, with a focus on its economic applications for remediating hazardous contaminants. Our assessment is based on over 200 publications from the past decade. Biochar, a carbon-rich material, can be derived from various organic waste sources, such as food waste and urban sewage sludge. Researchers are particularly interested in biochar due to its high carbon content, cation exchange capacity, substantial specific surface area, and stable structure. We investigate how the physical and chemical properties of biochar may vary based on the feedstock used, providing a comprehensive overview of biochar and its composition for pollution remediation. The review also discusses common techniques such as gasification, hydrothermal carbonization, and pyrolysis used to produce biochar. We analyze current research on the mechanisms involved in pollutant treatment using biochar and its composites while also addressing future directions in biochar research.
{"title":"Recent Advancements in Biochar and its Composite for the Remediation of Hazardous Pollutants","authors":"Akshay Verma, Gaurav Sharma, Amit Kumar, Pooja Dhiman, F. J. Stadler","doi":"10.2174/0115734110286724240318051113","DOIUrl":"https://doi.org/10.2174/0115734110286724240318051113","url":null,"abstract":": Biochar has garnered considerable attention in recent times due to its potential uses in the environmental field. In this study, we comprehensively examine and condense information on biochar production, characteristics, and adsorption mechanisms, with a focus on its economic applications for remediating hazardous contaminants. Our assessment is based on over 200 publications from the past decade. Biochar, a carbon-rich material, can be derived from various organic waste sources, such as food waste and urban sewage sludge. Researchers are particularly interested in biochar due to its high carbon content, cation exchange capacity, substantial specific surface area, and stable structure. We investigate how the physical and chemical properties of biochar may vary based on the feedstock used, providing a comprehensive overview of biochar and its composition for pollution remediation. The review also discusses common techniques such as gasification, hydrothermal carbonization, and pyrolysis used to produce biochar. We analyze current research on the mechanisms involved in pollutant treatment using biochar and its composites while also addressing future directions in biochar research.","PeriodicalId":10742,"journal":{"name":"Current Analytical Chemistry","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140314219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-26DOI: 10.2174/0115734110288767240318063641
Hamidreza Haghgoo Qezelje, M. Rajabi, Erfan Parsa, Sayeh Ghanbari Adivi, Mehrnaz Shahi, Alireza Asghari, M. Bazregar, Ahmad Hosseini-Bandegharaei
Determination of environmental pollutants is important due to their harmful effects on the health of living organisms. However, direct measurement of many of these pollutants is not possible due to their low concentrations, which necessitates the need for sample preparation methods. One of the rapid and simple sample preparation methods is the Air-Agitated Liquid-Liquid Microextraction (AALLME) method, which requires toxic organic solvents that can lead to environmental pollution. Therefore, finding green solvents like Deep Eutectic Solvents (DESs) to replace them can be investigated. A novel Deep Eutectic Solvent (DES) was synthesized from a combination of choline chloride and 2-phenylethanol with a molar ratio of 1:4, and it was examined using FT-IR analysis. This solvent was used in an AALLME method for measuring copper and cadmium heavy metal ions in complex real samples with Flame Atomic Absorption Spectroscopy (FAAS). The influential parameters of this method, such as solution pH (5.4), extraction cycles (12), and extraction solvent volume (440 μL), were optimized utilizing central composite design (CCD). Underneath the optimized circumstances, the detection limits for Cu2+ and Cd2+ were 0.14 and 0.09 ng mL-1, and the linear dynamic range was 0.47-50.0 and 0.32-22.5 ng mL-1, respectively. The preconcentration factors for these cations were 139.7 and 133.4, respectively. Combining this novel green solvent and rapid sample preparation method for the preconcentration and determination of the studied heavy metal ions has shown promising results in terms of enrichment factors and detection limit values.
由于环境污染物会对生物体的健康造成危害，因此环境污染物的测定非常重要。然而，由于许多污染物的浓度较低，因此无法对其进行直接测量，这就需要采用样品制备方法。其中一种快速简便的样品制备方法是空气沉积液-液微萃取（AALLME）法，这种方法需要使用有毒的有机溶剂，会造成环境污染。利用火焰原子吸收光谱（FAAS）将该溶剂用于 AALLME 法测量复杂实际样品中的铜和镉重金属离子。在优化的条件下，Cu2+和Cd2+的检出限分别为0.14和0.09 ng mL-1，线性范围分别为0.47～50.0和0.32～22.5 ng mL-1。结合这种新型绿色溶剂和快速样品制备方法对所研究的重金属离子进行预富集和测定，在富集因子和检测限值方面都显示出良好的结果。
{"title":"Application of a Green Deep Eutectic Solvent for Preconcentration and\u0000Determination of Copper and Cadmium in Food, Cosmetic, and Water\u0000Samples","authors":"Hamidreza Haghgoo Qezelje, M. Rajabi, Erfan Parsa, Sayeh Ghanbari Adivi, Mehrnaz Shahi, Alireza Asghari, M. Bazregar, Ahmad Hosseini-Bandegharaei","doi":"10.2174/0115734110288767240318063641","DOIUrl":"https://doi.org/10.2174/0115734110288767240318063641","url":null,"abstract":"\u0000\u0000Determination of environmental pollutants is important due to their harmful\u0000effects on the health of living organisms. However, direct measurement of many of these pollutants\u0000is not possible due to their low concentrations, which necessitates the need for sample preparation\u0000methods. One of the rapid and simple sample preparation methods is the Air-Agitated Liquid-Liquid\u0000Microextraction (AALLME) method, which requires toxic organic solvents that can lead to environmental\u0000pollution. Therefore, finding green solvents like Deep Eutectic Solvents (DESs) to replace\u0000them can be investigated.\u0000\u0000\u0000\u0000A novel Deep Eutectic Solvent (DES) was synthesized from a combination of choline\u0000chloride and 2-phenylethanol with a molar ratio of 1:4, and it was examined using FT-IR analysis.\u0000This solvent was used in an AALLME method for measuring copper and cadmium heavy metal ions\u0000in complex real samples with Flame Atomic Absorption Spectroscopy (FAAS).\u0000\u0000\u0000\u0000The influential parameters of this method, such as solution pH (5.4), extraction cycles (12),\u0000and extraction solvent volume (440 μL), were optimized utilizing central composite design (CCD).\u0000Underneath the optimized circumstances, the detection limits for Cu2+ and Cd2+ were 0.14 and 0.09\u0000ng mL-1, and the linear dynamic range was 0.47-50.0 and 0.32-22.5 ng mL-1, respectively. The preconcentration\u0000factors for these cations were 139.7 and 133.4, respectively.\u0000\u0000\u0000\u0000Combining this novel green solvent and rapid sample preparation method for the preconcentration\u0000and determination of the studied heavy metal ions has shown promising results in\u0000terms of enrichment factors and detection limit values.\u0000","PeriodicalId":10742,"journal":{"name":"Current Analytical Chemistry","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140379830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-21DOI: 10.2174/0115734110300566240314051129
Qirui Wang, Xian Liu, Ziqi Qin, Xiang Ge, Chengcheng Li, Lei Zhu, Xun Wang
Background: Tetracycline (TC), a commonly used antibiotic, is extensively utilized in the medical sector, leading to a significant annual discharge of tetracycline effluent into the water system, which harms both human health and the environment. background: Tetracycline (TC), a commonly used antibiotic, is extensively utilized in the medical sector, leading to a significant annual discharge of tetracycline effluent into the water system. This harms both human health and the environment. Objective: A novel technique was developed to address the issues of photogenerated carrier complexation and photocatalyst immobilization. Compared to traditional photocatalytic photoelectrodes, the suspended catalyst used in the photovoltaic synergy field is more stable and increases the solidliquid contact area between the catalyst and the pollutant. objective: This paper uses sol-gel-prepared Ag-doped-TiO2 materials for the photoelectrocatalytic degradation of TC. Methods: This paper uses sol-gel-prepared Ag-doped-TiO2 materials for the photoelectric synergistic field-catalyzed degradation of TC. The study examined how the Ag doping ratio, calcination conditions, catalyst injection, pH, electrolytes, and electrolyte injection affected photoelectric synergistic field-catalyzed degradation. The experiments were performed in a photocomposite field with a constant 50 mA current and a 357 nm UV lamp for 60 minutes. The composites underwent characterization using XRD, TEM, and XPS techniques. method: The study examined how the Ag doping ratio, calcination conditions, catalyst injection, pH, electrolytes, and electrolyte injection affected photoelectrocatalytic activity. The experiments were done in a photocomposite field with a constant 50 mA current and a 357 nm UV lamp for 60 minutes. The composites underwent characterization using XRD, TEM, and XPS techniques. Results: Ag-TiO2 photoelectric synergistic field-catalyzed reaction with 357 nm ultraviolet lamp irradiation for 60 min and a constant current of 50 mA degraded 5 mg/LTC under preparation conditions of molar doping ratio of Ti: Ag=100:0.5, roasting temperature of 500 °C, and roasting time of 2 h. The photoelectric synergistic field-catalyzed degradation process achieved a degradation rate of 90.49% for 5 mg/L TC, surpassing the combined degradation rates of electrocatalysis and photocatalysis. The quenching experiments demonstrated that the degradation rate of TC decreased from 90.49% in the absence of a quencher to 53.23%, 42.58%, and 74.52%. The presence of •OH had a more significant impact than h+ and •O2-. Conclusion: The findings suggest that Ag-TiO2 significantly enhanced the efficacy of photoelectric synergistic field-catalyzed degradation and can be employed to treat high-saline and lowconcentration TC. This establishes a benchmark for using photoelectrocatalytic materials based on titanium in treating organic wastewater. result: Ag-TiO2 photoelectrocatalytic reaction with 357 nm ultraviolet lamp irr
{"title":"Ag-TiO2 Photovoltaic Synergistic Field-catalyzed Degradation Performance of Tetracycline","authors":"Qirui Wang, Xian Liu, Ziqi Qin, Xiang Ge, Chengcheng Li, Lei Zhu, Xun Wang","doi":"10.2174/0115734110300566240314051129","DOIUrl":"https://doi.org/10.2174/0115734110300566240314051129","url":null,"abstract":"Background: Tetracycline (TC), a commonly used antibiotic, is extensively utilized in the medical sector, leading to a significant annual discharge of tetracycline effluent into the water system, which harms both human health and the environment. background: Tetracycline (TC), a commonly used antibiotic, is extensively utilized in the medical sector, leading to a significant annual discharge of tetracycline effluent into the water system. This harms both human health and the environment. Objective: A novel technique was developed to address the issues of photogenerated carrier complexation and photocatalyst immobilization. Compared to traditional photocatalytic photoelectrodes, the suspended catalyst used in the photovoltaic synergy field is more stable and increases the solidliquid contact area between the catalyst and the pollutant. objective: This paper uses sol-gel-prepared Ag-doped-TiO2 materials for the photoelectrocatalytic degradation of TC. Methods: This paper uses sol-gel-prepared Ag-doped-TiO2 materials for the photoelectric synergistic field-catalyzed degradation of TC. The study examined how the Ag doping ratio, calcination conditions, catalyst injection, pH, electrolytes, and electrolyte injection affected photoelectric synergistic field-catalyzed degradation. The experiments were performed in a photocomposite field with a constant 50 mA current and a 357 nm UV lamp for 60 minutes. The composites underwent characterization using XRD, TEM, and XPS techniques. method: The study examined how the Ag doping ratio, calcination conditions, catalyst injection, pH, electrolytes, and electrolyte injection affected photoelectrocatalytic activity. The experiments were done in a photocomposite field with a constant 50 mA current and a 357 nm UV lamp for 60 minutes. The composites underwent characterization using XRD, TEM, and XPS techniques. Results: Ag-TiO2 photoelectric synergistic field-catalyzed reaction with 357 nm ultraviolet lamp irradiation for 60 min and a constant current of 50 mA degraded 5 mg/LTC under preparation conditions of molar doping ratio of Ti: Ag=100:0.5, roasting temperature of 500 °C, and roasting time of 2 h. The photoelectric synergistic field-catalyzed degradation process achieved a degradation rate of 90.49% for 5 mg/L TC, surpassing the combined degradation rates of electrocatalysis and photocatalysis. The quenching experiments demonstrated that the degradation rate of TC decreased from 90.49% in the absence of a quencher to 53.23%, 42.58%, and 74.52%. The presence of •OH had a more significant impact than h+ and •O2-. Conclusion: The findings suggest that Ag-TiO2 significantly enhanced the efficacy of photoelectric synergistic field-catalyzed degradation and can be employed to treat high-saline and lowconcentration TC. This establishes a benchmark for using photoelectrocatalytic materials based on titanium in treating organic wastewater. result: Ag-TiO2 photoelectrocatalytic reaction with 357 nm ultraviolet lamp irr","PeriodicalId":10742,"journal":{"name":"Current Analytical Chemistry","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140204045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: This paper describes a new, digital image colourimetry-based format for the quantification of analytes in an aqueous solution. Method: The proposed method is based on analyte pre-concentration by adsorption onto Bentone LT. Bentone LT pellet isolation comes after adsorption, followed by in-situ application of an analyteselective chromogenic reaction. The resulting pellet colouration is captured by the phone’s integrated camera and assessed using the free open-source image processing software, ImageJ. Responses are calibrated and quantified. Results: We tested the applicability of the proposed methodology for the quantification of specific model analytes which are of concern in environmental matrices (methyl red, Co(II), uric acid, topotecan). The smartphone-based assay was proven reliable in quantifying the model analytes (standard recovery of 82-116%), alone or in mixture, from dilute aqueous solutions and was found to depict accurately the adsorption behaviour followed photometrically in solution. Lower limit of linearity was calculated at 0.05, 0.11, 0.85 and 0.20 μg/mL for methyl red, Co(II), uric acid, and topotecan, respectively. The proposed format was found superior when compared to alternative published photometric/ colourimetric assays in terms of the lower limit of linearity. In the presence of possible adsorption interferents, the lower limit of linear response was shifted to slightly higher concentrations for topotecan i.e. from 0.2 μg/mL to 0.5 μg/mL. Conclusion: We here demonstrate the extended applicability of the proposed methodology for the smartphone-based quantification of the specific model analytes. The applicability of this analysis format likely extends to other analytes, where analyte-specific colour formation is feasible.
{"title":"Smartphone-Based Colourimetric Detection of Methyl Red, Co(II), Uric Acid, and Topotecan after Pre-concentration onto a Hectorite Clay-Hydroxyethylcellulose Hybrid","authors":"Anastasios Phoebus Mazarakis, Georgia Eleni Tsotsou","doi":"10.2174/0115734110290080240314043658","DOIUrl":"https://doi.org/10.2174/0115734110290080240314043658","url":null,"abstract":"Objective: This paper describes a new, digital image colourimetry-based format for the quantification of analytes in an aqueous solution. Method: The proposed method is based on analyte pre-concentration by adsorption onto Bentone LT. Bentone LT pellet isolation comes after adsorption, followed by in-situ application of an analyteselective chromogenic reaction. The resulting pellet colouration is captured by the phone’s integrated camera and assessed using the free open-source image processing software, ImageJ. Responses are calibrated and quantified. Results: We tested the applicability of the proposed methodology for the quantification of specific model analytes which are of concern in environmental matrices (methyl red, Co(II), uric acid, topotecan). The smartphone-based assay was proven reliable in quantifying the model analytes (standard recovery of 82-116%), alone or in mixture, from dilute aqueous solutions and was found to depict accurately the adsorption behaviour followed photometrically in solution. Lower limit of linearity was calculated at 0.05, 0.11, 0.85 and 0.20 μg/mL for methyl red, Co(II), uric acid, and topotecan, respectively. The proposed format was found superior when compared to alternative published photometric/ colourimetric assays in terms of the lower limit of linearity. In the presence of possible adsorption interferents, the lower limit of linear response was shifted to slightly higher concentrations for topotecan i.e. from 0.2 μg/mL to 0.5 μg/mL. Conclusion: We here demonstrate the extended applicability of the proposed methodology for the smartphone-based quantification of the specific model analytes. The applicability of this analysis format likely extends to other analytes, where analyte-specific colour formation is feasible.","PeriodicalId":10742,"journal":{"name":"Current Analytical Chemistry","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140204043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
: In today’s era, detection of disease is utmost important for the management of disease. Early detection leads to early management of disease. Paper-based microfluidic devices are promising technologies that are cost-effective, portable and easy to use over conventional methods. In addition, paper-based microfluidics offers low reagent/sample volume, less response time and can be used in resource-limited settings. Researchers are highly fascinated by this technology as it has a lot of potential to convert into commercial monitoring devices. The present article covers the uses of paper-based microfluidic technology for the swift and sensitive detection of pathogens from diverse samples, viz. food, water and blood. In this comprehensive review, paper-based microfluidic devices are introduced, including the basic concepts, current status and applications, along with the discussion of the limitations of microfluidics for the detection of pathogens. Although paper-based microfluidic devices are being developed, their commercialization requires simplification of manufacturing processes, reduction in production costs as well as an increase in production efficiency. Nonetheless, the integration of artificial intelligence (AI) and the Internet of Things (IoT) like smartphones, digital cameras, webcam etc. with paper-associated diagnosis has transformed the point-of-care (POC) diagnostics.
{"title":"Paper-based Microfluidic Devices for the Analysis of Various Pathogens from Diverse Samples","authors":"Namita Ashish Singh, Nitish Rai, Ashish Kumar Singh, Vidhi Jain, Jagriti Narang","doi":"10.2174/0115734110292458240306055653","DOIUrl":"https://doi.org/10.2174/0115734110292458240306055653","url":null,"abstract":": In today’s era, detection of disease is utmost important for the management of disease. Early detection leads to early management of disease. Paper-based microfluidic devices are promising technologies that are cost-effective, portable and easy to use over conventional methods. In addition, paper-based microfluidics offers low reagent/sample volume, less response time and can be used in resource-limited settings. Researchers are highly fascinated by this technology as it has a lot of potential to convert into commercial monitoring devices. The present article covers the uses of paper-based microfluidic technology for the swift and sensitive detection of pathogens from diverse samples, viz. food, water and blood. In this comprehensive review, paper-based microfluidic devices are introduced, including the basic concepts, current status and applications, along with the discussion of the limitations of microfluidics for the detection of pathogens. Although paper-based microfluidic devices are being developed, their commercialization requires simplification of manufacturing processes, reduction in production costs as well as an increase in production efficiency. Nonetheless, the integration of artificial intelligence (AI) and the Internet of Things (IoT) like smartphones, digital cameras, webcam etc. with paper-associated diagnosis has transformed the point-of-care (POC) diagnostics.","PeriodicalId":10742,"journal":{"name":"Current Analytical Chemistry","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140153133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：