Pub Date : 2024-05-03DOI: 10.2174/0115734110294079240424103357
Hamed M. Al-Saidia, Sikandar Khan
: Heavy metal pollution is one of the most serious environmental problems, because of the non-degradable nature of heavy metals and their accumulation in the food chain, which poses a severe threat to the environment and human health even at low concentrations. Most of these metal ions can coordinate with biological molecules and disturb their function. Exposure to heavy metals can cause different health threats such as endothelial dysfunction, allergy, infant mortality, cancer, neurological diseases, respiratory diseases, oxidative stress, cardiovascular disorders and kidney diseases. Therefore the detection and removal of these toxic species are very important. Deep eutectic solvents (DESs) are green solvents and have excellent applications in many fields. They contain nonsymmetrical ions that have low lattice energy, low vapor pressure, dipolar nature, nonflammability, low volatility, low melting points, excellent thermal and chemical stability and high solubility. DESs are also better in terms of the availability of raw materials, easy synthetic procedure, low cost of their starting materials and their easy storage. DESs have an excellent ability for the detection and removal of heavy metal ions. In this review, we discussed various DES-based spectrophotometric and fluorimetric chemosensors for the detection of heavy metal ions in different matrixes. Additionally, we have also explored the capabilities of different DESs in removing heavy metals.
:重金属污染是最严重的环境问题之一，因为重金属具有不可降解的特性，而且会在食物链中积累，即使浓度很低，也会对环境和人类健康构成严重威胁。这些金属离子大多能与生物分子配位，干扰它们的功能。接触重金属会导致不同的健康威胁，如内皮功能障碍、过敏、婴儿死亡、癌症、神经系统疾病、呼吸系统疾病、氧化应激、心血管疾病和肾脏疾病。因此，检测和清除这些有毒物质非常重要。深共晶溶剂（DES）是一种绿色溶剂，在许多领域都有出色的应用。它们含有非对称离子，具有低晶格能、低蒸气压、双极性、不可燃、低挥发性、低熔点、优异的热稳定性和化学稳定性以及高溶解性。此外，DES 还具有原料易得、合成过程简单、起始原料成本低和易于储存等优点。DES 具有出色的重金属离子检测和去除能力。在本综述中，我们讨论了各种基于 DES 的分光光度法和荧光化学传感器，用于检测不同基质中的重金属离子。此外，我们还探讨了不同 DES 在去除重金属方面的能力。
{"title":"Recent Advancement in the Development of Detection and Removal of Heavy Metal Ions by Deep Eutectic Solvents: A Review","authors":"Hamed M. Al-Saidia, Sikandar Khan","doi":"10.2174/0115734110294079240424103357","DOIUrl":"https://doi.org/10.2174/0115734110294079240424103357","url":null,"abstract":": Heavy metal pollution is one of the most serious environmental problems, because of the non-degradable nature of heavy metals and their accumulation in the food chain, which poses a severe threat to the environment and human health even at low concentrations. Most of these metal ions can coordinate with biological molecules and disturb their function. Exposure to heavy metals can cause different health threats such as endothelial dysfunction, allergy, infant mortality, cancer, neurological diseases, respiratory diseases, oxidative stress, cardiovascular disorders and kidney diseases. Therefore the detection and removal of these toxic species are very important. Deep eutectic solvents (DESs) are green solvents and have excellent applications in many fields. They contain nonsymmetrical ions that have low lattice energy, low vapor pressure, dipolar nature, nonflammability, low volatility, low melting points, excellent thermal and chemical stability and high solubility. DESs are also better in terms of the availability of raw materials, easy synthetic procedure, low cost of their starting materials and their easy storage. DESs have an excellent ability for the detection and removal of heavy metal ions. In this review, we discussed various DES-based spectrophotometric and fluorimetric chemosensors for the detection of heavy metal ions in different matrixes. Additionally, we have also explored the capabilities of different DESs in removing heavy metals.","PeriodicalId":10742,"journal":{"name":"Current Analytical Chemistry","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140834026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Camptothecin (CPT) is pivotal in cancer treatment, derived from various CPT-producing plant species, and is a fundamental component in synthesizing valuable cancer drugs like Irnotican and Topotecan. Sourcing from nature poses conservation issues, fostering interest in the herbaceous Ophiorrhiza plant as a more sustainable alternative. Ophiorrhiza species in Sri Lanka lack comprehensive study, warranting exploration for echo-friendly anticancer compound production. Objectives: This study examines CPT and analog content in Ophiorrhiza mungos, O. pectinata, and O. rugosa across diverse Sri Lankan regions. Methods: The study employs Thin Layer Chromatography (TLC), High-Performance Liquid Chromatography-DAD (HPLC-DAD), and Liquid Chromatography-Mass Spectrometry (LC-MS) to quantify and confirm CPT and its analogs. Results: Significant variations in the content of CPT and its analogs were observed among plant parts and regions. O. mungos from Deraniyagala and Bibile regions notably exhibited elevated CPT levels in fruits and roots. O. rugosa var. Angustifolia and O. pectinata also exhibited a considerable content of CPT in their roots, though it was significantly lower (p < 0.005) than O. mungos. Conclusion: The study validates analytical methods for specificity, linearity, precision, accuracy, and sensitivity per ICH guidelines. The results indicate that Ophiorrhiza species, especially O. mungos and O. rugosa var. Angustifolia holds the potential to be a sustainable source of CPT. Optimizing cultivation practices offers an eco-friendly solution for anticancer compound production, alleviating species threats and conserving biodiversity.
简介喜树碱（CPT）在癌症治疗中起着关键作用，它来源于各种生产喜树碱的植物物种，是合成伊诺替康和托泊替康等珍贵抗癌药物的基本成分。从大自然中获取资源会带来保护问题，因此人们对草本植物 Ophiorrhiza 产生了兴趣，认为这是一种更具可持续性的替代品。斯里兰卡的草本植物缺乏全面的研究，因此有必要对其进行探索，以生产对环境友好的抗癌化合物。研究目的：本研究考察了斯里兰卡不同地区的 Ophiorrhiza mungos、O. pectinata 和 O. rugosa 中的 CPT 和类似物含量。研究方法：研究采用薄层色谱法（TLC）、高效液相色谱法（HPLC-DAD）和液相色谱-质谱法（LC-MS）对 CPT 及其类似物进行定量和确认。结果：在不同植物部位和地区，CPT 及其类似物的含量存在显著差异。来自 Deraniyagala 和 Bibile 地区的 O. mungos 果实和根部的 CPT 含量明显升高。O. rugosa var. Angustifolia 和 O. pectinata 的根中也显示出相当高的 CPT 含量，但明显低于 O. mungos（p < 0.005）。结论该研究验证了符合 ICH 指南的特异性、线性、精确性、准确性和灵敏度分析方法。结果表明，Ophiorrhiza 物种，尤其是 O. mungos 和 O. rugosa var. Angustifolia 有潜力成为 CPT 的可持续来源。优化栽培方法可为抗癌化合物的生产提供生态友好型解决方案，减轻物种威胁并保护生物多样性。
{"title":"Camptothecin and its Analogs: High-Yielding Ophiorrhiza Species from Sri Lanka for Sustainable Anticancer Compound Production","authors":"Hewagamage Dona Gihani Asmeer Ranasinghe, Peramune Arachchilage Amila Saman Prasad Kumara, Koonara Mudiyanselage Thilini Dinesha Weerasekara, Poruthotage Pradeep Rasika Perera, Nazeera Salim, Chandrika Udumalagala Gamage","doi":"10.2174/0115734110285332240424093539","DOIUrl":"https://doi.org/10.2174/0115734110285332240424093539","url":null,"abstract":"Introduction: Camptothecin (CPT) is pivotal in cancer treatment, derived from various CPT-producing plant species, and is a fundamental component in synthesizing valuable cancer drugs like Irnotican and Topotecan. Sourcing from nature poses conservation issues, fostering interest in the herbaceous Ophiorrhiza plant as a more sustainable alternative. Ophiorrhiza species in Sri Lanka lack comprehensive study, warranting exploration for echo-friendly anticancer compound production. Objectives: This study examines CPT and analog content in Ophiorrhiza mungos, O. pectinata, and O. rugosa across diverse Sri Lankan regions. Methods: The study employs Thin Layer Chromatography (TLC), High-Performance Liquid Chromatography-DAD (HPLC-DAD), and Liquid Chromatography-Mass Spectrometry (LC-MS) to quantify and confirm CPT and its analogs. Results: Significant variations in the content of CPT and its analogs were observed among plant parts and regions. O. mungos from Deraniyagala and Bibile regions notably exhibited elevated CPT levels in fruits and roots. O. rugosa var. Angustifolia and O. pectinata also exhibited a considerable content of CPT in their roots, though it was significantly lower (p < 0.005) than O. mungos. Conclusion: The study validates analytical methods for specificity, linearity, precision, accuracy, and sensitivity per ICH guidelines. The results indicate that Ophiorrhiza species, especially O. mungos and O. rugosa var. Angustifolia holds the potential to be a sustainable source of CPT. Optimizing cultivation practices offers an eco-friendly solution for anticancer compound production, alleviating species threats and conserving biodiversity.","PeriodicalId":10742,"journal":{"name":"Current Analytical Chemistry","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140834147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Therefore, the development of reliable analytical techniques with high selectivity and sensitivity to detect hydrazine is required for the protection of human health and safety. Objectives: Traditional methods for detecting N2H4 are frequently time-consuming, less accurate, and unsuitable for the analysis of living systems. Numerous fluorescent probes for hydrazine have been produced and gained some valuable results recently. The creation of a simple fluorescent probe for hydrazine detection is the goal of this project Method: In this study, 300 µL of probe 3-methyl-2-oxo-2H-chromen-7-yl propionate (MOCP) was mixed with an equivalent amount of the solution of each analyte to obtain the measurement solution. Following a 10-minute room temperature incubation period, the fluorescence spectra of the resultant solution were recorded. Results: The fluorescence intensity of the probe was noticeably enhanced when N2H4 was added to the probe, but almost no fluorescence enhancement was observed when other competitive ions were added. Conclusion: A hydrazine fluorescent probe based on 4-hydroxycoumarin fluorophore was developed. The probe MOCP displayed high sensitivity and selectivity for hydrazine, with a color change from colourless to blue for detection by the naked eye. Moreover, it demonstrated a low detection limit of 20 nM and a fast reaction time of 30 s.
{"title":"A Fluorescent Probe for Hydrazine Based on 4-hydroxycoumarin with High Selectivity and Sensitivity","authors":"Fang Fang, Wen-Di Han, Fang Ke, Shun Liu, Li-Peng Li, Mei Wu","doi":"10.2174/0115734110281725231218043256","DOIUrl":"https://doi.org/10.2174/0115734110281725231218043256","url":null,"abstract":"Background: Therefore, the development of reliable analytical techniques with high selectivity and sensitivity to detect hydrazine is required for the protection of human health and safety. Objectives: Traditional methods for detecting N2H4 are frequently time-consuming, less accurate, and unsuitable for the analysis of living systems. Numerous fluorescent probes for hydrazine have been produced and gained some valuable results recently. The creation of a simple fluorescent probe for hydrazine detection is the goal of this project Method: In this study, 300 µL of probe 3-methyl-2-oxo-2H-chromen-7-yl propionate (MOCP) was mixed with an equivalent amount of the solution of each analyte to obtain the measurement solution. Following a 10-minute room temperature incubation period, the fluorescence spectra of the resultant solution were recorded. Results: The fluorescence intensity of the probe was noticeably enhanced when N2H4 was added to the probe, but almost no fluorescence enhancement was observed when other competitive ions were added. Conclusion: A hydrazine fluorescent probe based on 4-hydroxycoumarin fluorophore was developed. The probe MOCP displayed high sensitivity and selectivity for hydrazine, with a color change from colourless to blue for detection by the naked eye. Moreover, it demonstrated a low detection limit of 20 nM and a fast reaction time of 30 s.","PeriodicalId":10742,"journal":{"name":"Current Analytical Chemistry","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140834025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-30DOI: 10.2174/0115734110299035240422114008
Pengwei Li, Xiaoning Xia
: Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS) is becoming a powerful tool in the Lithium-Ion Batteries (LIBs) field due to its excellent resolution and sensitivity, as well as its ability to provide spectrally and depth-resolved information. The perspective comprehensively delves into the application of ToF-SIMS in two major areas of LIBs research. Firstly, the article elucidates how ToF-SIMS has been instrumental in deciphering the Solid Electrolyte Interphase (SEI) composition and analyzing electrolyte aging. The insights gleaned from such studies have paved the way for enhancing the longevity and safety of LIBs. Secondly, we explore the role of ToF-SIMS in scrutinizing the distribution of interface reactions, which are critical for understanding charge and discharge mechanisms. The analysis aids in optimizing the interface properties, thereby improving battery performance. Such detections are paramount in ensuring the safety and operational stability of batteries. Overall, the integration of ToF-SIMS in LIBs research offers a promising avenue for the development of advanced and safer energy storage systems.
{"title":"Application of Time-of-flight Secondary Ion Mass Spectrometry in Lithium-ion Batteries","authors":"Pengwei Li, Xiaoning Xia","doi":"10.2174/0115734110299035240422114008","DOIUrl":"https://doi.org/10.2174/0115734110299035240422114008","url":null,"abstract":": Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS) is becoming a powerful tool in the Lithium-Ion Batteries (LIBs) field due to its excellent resolution and sensitivity, as well as its ability to provide spectrally and depth-resolved information. The perspective comprehensively delves into the application of ToF-SIMS in two major areas of LIBs research. Firstly, the article elucidates how ToF-SIMS has been instrumental in deciphering the Solid Electrolyte Interphase (SEI) composition and analyzing electrolyte aging. The insights gleaned from such studies have paved the way for enhancing the longevity and safety of LIBs. Secondly, we explore the role of ToF-SIMS in scrutinizing the distribution of interface reactions, which are critical for understanding charge and discharge mechanisms. The analysis aids in optimizing the interface properties, thereby improving battery performance. Such detections are paramount in ensuring the safety and operational stability of batteries. Overall, the integration of ToF-SIMS in LIBs research offers a promising avenue for the development of advanced and safer energy storage systems.","PeriodicalId":10742,"journal":{"name":"Current Analytical Chemistry","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140834146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Essential oils are utilized in various food applications and are a rich source of naturally occurring volatile components. The extraction of essential oils has used conventional techniques for several years, but these methods require a long duration of time, more solvent, and high energy. However, recent advancements have led to novel and eco-friendly techniques that significantly enhance the essential oil yield while minimizing the use of resources. Method: This study describes the recent research on the extraction of essential oils and their components, focusing on microwave-assisted extraction (MAE) and ultrasound-assisted extraction (UAE). Result: This review explores the instrumentation, mechanism, and applications behind MAE and UAE. It also describes the emerging technologies for the extraction of essential oils, along with their optimized conditions. Conclusion: These techniques represent a more sustainable and efficient approach for the extraction of essential oil from various plant sources, aligning with the principles of green chemistry.
{"title":"A New Revolutionary Green Technology for the Extraction of Essential Oil Using Microwave and Ultrasound-assisted Techniques","authors":"Pallavi Barik, komal Dagar, Rahul Makhija, Alamjot Singh, Vivek Asati","doi":"10.2174/0115734110296570240422063010","DOIUrl":"https://doi.org/10.2174/0115734110296570240422063010","url":null,"abstract":"Background: Essential oils are utilized in various food applications and are a rich source of naturally occurring volatile components. The extraction of essential oils has used conventional techniques for several years, but these methods require a long duration of time, more solvent, and high energy. However, recent advancements have led to novel and eco-friendly techniques that significantly enhance the essential oil yield while minimizing the use of resources. Method: This study describes the recent research on the extraction of essential oils and their components, focusing on microwave-assisted extraction (MAE) and ultrasound-assisted extraction (UAE). Result: This review explores the instrumentation, mechanism, and applications behind MAE and UAE. It also describes the emerging technologies for the extraction of essential oils, along with their optimized conditions. Conclusion: These techniques represent a more sustainable and efficient approach for the extraction of essential oil from various plant sources, aligning with the principles of green chemistry.","PeriodicalId":10742,"journal":{"name":"Current Analytical Chemistry","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140834021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-19DOI: 10.2174/0115734110301664240409055056
Min Yen Yeh, Ruei Ying You, Po Wen Cheng, Shih-Syuan Hwang, Gui-Cheng Hu, S. Chang
Polystyrene nanospheres are used as a substrate for the hydrothermal coating of tungsten trioxide (WO3) to form a core-shell composite of PS@WO3. The core-shell structure is used for the next sintering step. This produces porous WO3. The focus of this study is on the role of porous WO3 in enhancing photocatalytic performance. The hydrothermal method was employed for coating, and the surface morphology, as well as the structural properties of WO3-coated PS spheres, were systematically investigated using SEM and XRD analyses. Additionally, the sintering process was introduced to enhance the material by inducing rupture in the PS sphere core, creating voids that significantly increased the material's surface area. The primary objective is to elucidate the correlation between sintering temperatures, crystallographic structures, and the resulting degradation efficiency of WO3-coated PS spheres. Specific attention is given to the role of hexagonal and orthorhombic structures and their impact on photocatalytic performance. The evaluation of the effect of sintering temperature on photodegradation efficiency highlighted the crucial role of sintering temperature. Un-sintered and 300°C sintered WO3, both having a hexagonal crystalline structure, exhibited superior degradation efficiencies compared to samples sintered at higher temperatures (400°C and 500°C). In particular, the 300°C sintered WO3 outperformed its un-sintered counterpart despite identical crystalline structures. The performance of the PS@WO3 composite was assessed to determine the enhanced role of porous WO3. The porous WO3 obtained, in particular by the sintering of the core-shell PS@WO3 composites at 300°C, showed a remarkable improvement in the degradation efficiency. These composite demonstrated over 95% efficiency within 10 minutes and achieved near complete (100%) degradation for a further 10 minutes, surpassing the performance of pure WO3. It is important to clarify that while the final product was predominantly WO3 after the sintering process, the inclusion of PS served a critical purpose in creating voids during sintering. The PS@WO3 composite structure used as a resource for the preparation of porous WO3, even with a potentially reduced PS composition, has been found to play a significant role in influencing the surface area of the material, and consequently the photocatalytic performance. The study has highlighted the importance of crystalline structure and sintering conditions in optimizing the efficiency of photocatalytic materials. The porous WO3 obtained, in particular by the sintering of the core-shell PS@WO3 composites at 300°C, showed promising potential for applications under UV and visible LED light irradiation. These results provide valuable insights for the development of advanced photocatalytic materials with improved performance, highlighting WO3 as the key contributor to the observed improvements.
{"title":"Sintering Driven Void Formation in PS@WO3 Core-Shell Composites: A Photodegradation Enhancement Strategy","authors":"Min Yen Yeh, Ruei Ying You, Po Wen Cheng, Shih-Syuan Hwang, Gui-Cheng Hu, S. Chang","doi":"10.2174/0115734110301664240409055056","DOIUrl":"https://doi.org/10.2174/0115734110301664240409055056","url":null,"abstract":"\u0000\u0000Polystyrene nanospheres are used as a substrate for the hydrothermal coating\u0000of tungsten trioxide (WO3) to form a core-shell composite of PS@WO3. The core-shell structure\u0000is used for the next sintering step. This produces porous WO3. The focus of this study is on the role\u0000of porous WO3 in enhancing photocatalytic performance.\u0000\u0000\u0000\u0000The hydrothermal method was employed for coating, and the surface morphology, as well\u0000as the structural properties of WO3-coated PS spheres, were systematically investigated using SEM\u0000and XRD analyses. Additionally, the sintering process was introduced to enhance the material by\u0000inducing rupture in the PS sphere core, creating voids that significantly increased the material's surface\u0000area.\u0000\u0000\u0000\u0000The primary objective is to elucidate the correlation between sintering temperatures, crystallographic structures, and the resulting degradation efficiency of WO3-coated PS spheres. Specific attention is given to the role of hexagonal and orthorhombic structures and their impact on photocatalytic performance.\u0000\u0000\u0000\u0000The evaluation of the effect of sintering temperature on photodegradation efficiency highlighted\u0000the crucial role of sintering temperature. Un-sintered and 300°C sintered WO3, both having a\u0000hexagonal crystalline structure, exhibited superior degradation efficiencies compared to samples\u0000sintered at higher temperatures (400°C and 500°C). In particular, the 300°C sintered WO3 outperformed\u0000its un-sintered counterpart despite identical crystalline structures. The performance of the\u0000PS@WO3 composite was assessed to determine the enhanced role of porous WO3. The porous WO3\u0000obtained, in particular by the sintering of the core-shell PS@WO3 composites at 300°C, showed a\u0000remarkable improvement in the degradation efficiency. These composite demonstrated over 95%\u0000efficiency within 10 minutes and achieved near complete (100%) degradation for a further 10\u0000minutes, surpassing the performance of pure WO3. It is important to clarify that while the final product\u0000was predominantly WO3 after the sintering process, the inclusion of PS served a critical purpose\u0000in creating voids during sintering. The PS@WO3 composite structure used as a resource for the preparation\u0000of porous WO3, even with a potentially reduced PS composition, has been found to play a\u0000significant role in influencing the surface area of the material, and consequently the photocatalytic\u0000performance.\u0000\u0000\u0000\u0000The study has highlighted the importance of crystalline structure and sintering conditions\u0000in optimizing the efficiency of photocatalytic materials. The porous WO3 obtained, in particular\u0000by the sintering of the core-shell PS@WO3 composites at 300°C, showed promising potential for\u0000applications under UV and visible LED light irradiation. These results provide valuable insights for\u0000the development of advanced photocatalytic materials with improved performance, highlighting\u0000WO3 as the key contributor to the observed improvements.\u0000","PeriodicalId":10742,"journal":{"name":"Current Analytical Chemistry","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140683059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-16DOI: 10.2174/0115734110302106240404105903
Sa’adatu Eri Mohammed, Hamza Badamasi, Augustine A. Unimke, Naseer Inuwa Durumin Iya, Aderibigbe Deborah Olubunmi, Chinyere Okoro, Onyemaechi Okezie, Abdul Ademola Olaleye
: Access to clean air, a vital necessity for life, faces severe constraints globally due to industrialization and urbanization, leading to widespread air quality deterioration. To safeguard human health and the environment from detrimental effects, the essential components of proper monitoring, assessment, and management of air quality are paramount. Conventional air quality analytical techniques such as gas chromatography/ mass spectrometry, selected ion flow tube mass spectrometry, thermal desorption/ gas chromatography, and mass spectrometry are widely used for air quality analysis. These methods, however, are laborious, necessitate sample preparation, require expansive and hazardous reagents, and have a high cost of equipment and maintenance. As such, more rapid, sensitive, specific, cost-effective, portable, user-friendly, and environmentally friendly analytical tools are required for efficient air quality monitoring and control. Over the years, various techniques have emerged to address these challenges, including mobile sensors, microbial monitoring, the Internet of Things (IoT), biomonitoring, and bio- and nanosensors in both indoor and outdoor settings. This paper offers an overview of recent advancements in air quality monitoring and assessment methods. The review encompasses sample preparations for air pollutants, data analysis methodologies, and monitoring strategies. It also delves into the crucial role of microorganisms in air quality analysis. Additionally, the paper explores the applications of the Internet of Things (IoT) and biosensors in air quality monitoring and assessment, elucidating their roles in advancing these endeavors. The paper concludes by presenting insightful perspectives on the current state of air quality monitoring techniques and outlining future directions for research and development in this critical field.
{"title":"An Overview of Recent Analytical Techniques for Air Quality Monitoring and Assessment","authors":"Sa’adatu Eri Mohammed, Hamza Badamasi, Augustine A. Unimke, Naseer Inuwa Durumin Iya, Aderibigbe Deborah Olubunmi, Chinyere Okoro, Onyemaechi Okezie, Abdul Ademola Olaleye","doi":"10.2174/0115734110302106240404105903","DOIUrl":"https://doi.org/10.2174/0115734110302106240404105903","url":null,"abstract":": Access to clean air, a vital necessity for life, faces severe constraints globally due to industrialization and urbanization, leading to widespread air quality deterioration. To safeguard human health and the environment from detrimental effects, the essential components of proper monitoring, assessment, and management of air quality are paramount. Conventional air quality analytical techniques such as gas chromatography/ mass spectrometry, selected ion flow tube mass spectrometry, thermal desorption/ gas chromatography, and mass spectrometry are widely used for air quality analysis. These methods, however, are laborious, necessitate sample preparation, require expansive and hazardous reagents, and have a high cost of equipment and maintenance. As such, more rapid, sensitive, specific, cost-effective, portable, user-friendly, and environmentally friendly analytical tools are required for efficient air quality monitoring and control. Over the years, various techniques have emerged to address these challenges, including mobile sensors, microbial monitoring, the Internet of Things (IoT), biomonitoring, and bio- and nanosensors in both indoor and outdoor settings. This paper offers an overview of recent advancements in air quality monitoring and assessment methods. The review encompasses sample preparations for air pollutants, data analysis methodologies, and monitoring strategies. It also delves into the crucial role of microorganisms in air quality analysis. Additionally, the paper explores the applications of the Internet of Things (IoT) and biosensors in air quality monitoring and assessment, elucidating their roles in advancing these endeavors. The paper concludes by presenting insightful perspectives on the current state of air quality monitoring techniques and outlining future directions for research and development in this critical field.","PeriodicalId":10742,"journal":{"name":"Current Analytical Chemistry","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140561709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-15DOI: 10.2174/0115734110297757240317065850
Parina Kumari, Sarwar Beg, Kamalinder K Singh, Vandita Kakkar
Aims:: Applicability of QbD-assisted analytical method for simultaneous detection of tetrahydrocurcumin and folic acid in developed nanostructured. background: Background: Diabetic foot ulcer (DFU), a multifactorial disorder involves chronic inflammation, oxidative stress and neuropathy. Current treatment therapies, involving the use of growth factors and skin substitutes being costly, are out of reach for the majority of patients. The present research explored the usefulness of (5929IN008, application number 202211045937) a combination of tetrahydrocurcumin and folic acid loaded nanostructured lipidic carriers. Background:: Diabetic foot ulcer (DFU) is a multifactorial disorder that involves chronic inflammation, oxidative stress and neuropathy. Current treatment therapies involving the use of growth factors and skin substitutes being costly, are out of reach for the majority of patients. The present research explored the usefulness of (5929IN008, application number 202211045937), a combination of tetrahydrocurcumin and folic acid-loaded nanostructured lipidic carriers. Objectives:: To develop and validate a QbD-assisted method for simultaneous analysis of tetrahydrocurcumin (THC) and folic acid (FA). Applicability of the above method to determine total drug content (TDC) and entrapment efficiency (EE) of nanostructured lipid carriers (NLCs) loaded THC and FA. Methods:: A high-performance liquid chromatographic (HPLC) method was developed, optimized and validated using Box-Behnken design for improved method performance. Chromatographic separation was conducted on a Supelco 250 x 4.6 mm (5 μm) column with optimized mobile phase composition containing tetrahydrofuran: citric acid buffer pH 3.5 (50:50) at a flow rate of 0.4 mL.min-1 and diode array detection between 210 and 360 nm. Results:: The method developed in a concentration range of 1 to 100 μg.mL-1 was found to be linear (R2 0.999, p≤0.001), accurate (99.10-101.70%) and precise with high recovery values in intra and inter-day results. The system adaptability and robustness evaluation revealed that the percent recovery ranged from 96.90 to 102.80%, and the percent relative standard deviation (%RSD) values were less than 2%. Moreover, the method was further applied for the determination of TDC (86±6% and 96±8%) and drug EE (81±21% and 73±13%) for THC and FA, respectively. Conclusion:: The investigation indicated the applicability of the developed and validated method for the estimation of THC and FA in the developed nanostructured lipidic carriers.
目的在开发的纳米结构中同时检测四氢姜黄素和叶酸的 QbD 辅助分析方法的适用性：背景：背景：糖尿病足溃疡（DFU）是一种多因素疾病，涉及慢性炎症、氧化应激和神经病变。目前的治疗方法包括使用生长因子和皮肤替代品，但这些方法成本高昂，大多数患者无法负担。本研究探讨了（5929IN008，申请号：202211045937）四氢姜黄素和叶酸组合纳米结构脂质载体的实用性。背景：：糖尿病足溃疡（DFU）是一种多因素疾病，涉及慢性炎症、氧化应激和神经病变。目前的治疗方法包括使用生长因子和皮肤替代品，但由于成本高昂，大多数患者无法负担。本研究探讨了四氢姜黄素和叶酸组合的纳米结构脂质载体（5929IN008，申请号 202211045937）的实用性。目标：：开发并验证同时分析四氢姜黄素（THC）和叶酸（FA）的 QbD 辅助方法。上述方法是否适用于测定负载四氢姜黄素和叶酸的纳米结构脂质载体（NLCs）的总药物含量（TDC）和包埋效率（EE）。方法：：采用方框-贝肯设计法开发、优化和验证了高效液相色谱（HPLC）方法，以提高方法的性能。色谱分离采用 Supelco 250 x 4.6 mm (5 μm)色谱柱，优化流动相组成为四氢呋喃：柠檬酸缓冲液 pH 3.5 (50:50)，流速为 0.4 mL.min-1，二极管阵列检测波长为 210 至 360 nm。结果该方法的线性（R2 0.999，p≤0.001）、准确度（99.10%-101.70%）和精密度高，日内和日间结果的回收率高，浓度范围为 1-100 μg.mL-1。系统适应性和稳健性评价表明，回收率在96.90%至102.80%之间，相对标准偏差（%RSD）小于2%。此外，该方法还可进一步用于 THC 和 FA 的 TDC 测定（86±6% 和 96±8%）和药物 EE 测定（81±21% 和 73±13%）。结论该研究表明，所开发和验证的方法适用于所开发的纳米结构脂质载体中四氢大麻酚和FA的测定。
{"title":"Applicability of QbD-assisted Analytical Method for Simultaneous Detection of Tetrahydrocurcumin and Folic Acid in Developed Nanostructured","authors":"Parina Kumari, Sarwar Beg, Kamalinder K Singh, Vandita Kakkar","doi":"10.2174/0115734110297757240317065850","DOIUrl":"https://doi.org/10.2174/0115734110297757240317065850","url":null,"abstract":"Aims:: Applicability of QbD-assisted analytical method for simultaneous detection of tetrahydrocurcumin and folic acid in developed nanostructured. background: Background: Diabetic foot ulcer (DFU), a multifactorial disorder involves chronic inflammation, oxidative stress and neuropathy. Current treatment therapies, involving the use of growth factors and skin substitutes being costly, are out of reach for the majority of patients. The present research explored the usefulness of (5929IN008, application number 202211045937) a combination of tetrahydrocurcumin and folic acid loaded nanostructured lipidic carriers. Background:: Diabetic foot ulcer (DFU) is a multifactorial disorder that involves chronic inflammation, oxidative stress and neuropathy. Current treatment therapies involving the use of growth factors and skin substitutes being costly, are out of reach for the majority of patients. The present research explored the usefulness of (5929IN008, application number 202211045937), a combination of tetrahydrocurcumin and folic acid-loaded nanostructured lipidic carriers. Objectives:: To develop and validate a QbD-assisted method for simultaneous analysis of tetrahydrocurcumin (THC) and folic acid (FA). Applicability of the above method to determine total drug content (TDC) and entrapment efficiency (EE) of nanostructured lipid carriers (NLCs) loaded THC and FA. Methods:: A high-performance liquid chromatographic (HPLC) method was developed, optimized and validated using Box-Behnken design for improved method performance. Chromatographic separation was conducted on a Supelco 250 x 4.6 mm (5 μm) column with optimized mobile phase composition containing tetrahydrofuran: citric acid buffer pH 3.5 (50:50) at a flow rate of 0.4 mL.min-1 and diode array detection between 210 and 360 nm. Results:: The method developed in a concentration range of 1 to 100 μg.mL-1 was found to be linear (R2 0.999, p≤0.001), accurate (99.10-101.70%) and precise with high recovery values in intra and inter-day results. The system adaptability and robustness evaluation revealed that the percent recovery ranged from 96.90 to 102.80%, and the percent relative standard deviation (%RSD) values were less than 2%. Moreover, the method was further applied for the determination of TDC (86±6% and 96±8%) and drug EE (81±21% and 73±13%) for THC and FA, respectively. Conclusion:: The investigation indicated the applicability of the developed and validated method for the estimation of THC and FA in the developed nanostructured lipidic carriers.","PeriodicalId":10742,"journal":{"name":"Current Analytical Chemistry","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140561825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-04DOI: 10.2174/0115734110300973240325131908
Mohammed A. Al-Anber, Wala Al-Qaisi, Idrees F. Al-Momani, Ahmed K. Hijazi, Dinara Sobola, Wasim Alhalasah, Zaid A. Al-Anber
Introduction:: This study synthesizes and characterizes a novel hybrid composite, SGdpm, to capture UO2 2+ ions from water. The composite has successfully formed by hosting covalently diphenylmethane-1,3-dione (dpm) within an inorganic silica gel matrix, showing promising potential for environmental remediation and nuclear waste management. Methods:: The preparation involved the reaction of tetraethylorthosilicate (TEOS) with diphenylmethane- 1,3-dione (dpm) under acidic conditions, resulting in white solids. The doped composite was characterized by Fourier Transform Infrared Spectroscopy (FTIR), revealing the presence of siloxane and Si-O-C bonds. The application of SG-dpm for capturing UO2 2+ ions from water was investigated, showing a shift in FTIR peaks and confirming the formation of SG-dpm-UO2 2+ as inner-sphere complexes. Scanning Electron Microscopy (SEM) revealed a non-uniform distribution of particles, essential for consistent behavior in applications such as adsorption. Results and Discussion:: Batch sorption experiments demonstrated temperature-dependent sorption behavior with increased efficiency at higher temperatures (T = 55 °C). The study also explored the influence of pH and initial concentration on UO2 2+ sorption, revealing optimal conditions at pH 5 and lower initial concentrations (1.0 mg L-1). Kinetic studies using pseudo-second-order models indicated a high efficiency of UO2 2+ ion removal (99 %) as a chemisorption process. Intraparticle diffusion models highlighted three distinct sorption stages. Sorption isotherm studies favored the Langmuir model, emphasizing monolayer adsorption. The thermodynamic analysis suggested an endothermic (ΔH = + 16.120 kJ mol-1) and spontaneous (ΔG = −25.113 to − 29.2449 kJ mol-1) sorption process. Selectivity studies demonstrated high efficiency in capturing Cu2+, Co2+, and Cr3+ ions, high degree selectivity of UO2 2+ ions (74 %), moderate efficiency for Fe3+ and Zn2+, and lower efficiency for Pb2+, Ni2+, and Cd2+, and poor efficiency for Mn2+ ions. In Conclusion,: SG-dpm exhibits promising potential for selective UO2 2+ ion removal, demonstrating favorable characteristics for various applications, including environmental remediation and nuclear waste management.
{"title":"Silica-Based 1,3-Diphenyl-1,3-Propanedione Composites: Efficient Uranium Capture for Environmental Remediation","authors":"Mohammed A. Al-Anber, Wala Al-Qaisi, Idrees F. Al-Momani, Ahmed K. Hijazi, Dinara Sobola, Wasim Alhalasah, Zaid A. Al-Anber","doi":"10.2174/0115734110300973240325131908","DOIUrl":"https://doi.org/10.2174/0115734110300973240325131908","url":null,"abstract":"Introduction:: This study synthesizes and characterizes a novel hybrid composite, SGdpm, to capture UO2 2+ ions from water. The composite has successfully formed by hosting covalently diphenylmethane-1,3-dione (dpm) within an inorganic silica gel matrix, showing promising potential for environmental remediation and nuclear waste management. Methods:: The preparation involved the reaction of tetraethylorthosilicate (TEOS) with diphenylmethane- 1,3-dione (dpm) under acidic conditions, resulting in white solids. The doped composite was characterized by Fourier Transform Infrared Spectroscopy (FTIR), revealing the presence of siloxane and Si-O-C bonds. The application of SG-dpm for capturing UO2 2+ ions from water was investigated, showing a shift in FTIR peaks and confirming the formation of SG-dpm-UO2 2+ as inner-sphere complexes. Scanning Electron Microscopy (SEM) revealed a non-uniform distribution of particles, essential for consistent behavior in applications such as adsorption. Results and Discussion:: Batch sorption experiments demonstrated temperature-dependent sorption behavior with increased efficiency at higher temperatures (T = 55 °C). The study also explored the influence of pH and initial concentration on UO2 2+ sorption, revealing optimal conditions at pH 5 and lower initial concentrations (1.0 mg L-1). Kinetic studies using pseudo-second-order models indicated a high efficiency of UO2 2+ ion removal (99 %) as a chemisorption process. Intraparticle diffusion models highlighted three distinct sorption stages. Sorption isotherm studies favored the Langmuir model, emphasizing monolayer adsorption. The thermodynamic analysis suggested an endothermic (ΔH = + 16.120 kJ mol-1) and spontaneous (ΔG = −25.113 to − 29.2449 kJ mol-1) sorption process. Selectivity studies demonstrated high efficiency in capturing Cu2+, Co2+, and Cr3+ ions, high degree selectivity of UO2 2+ ions (74 %), moderate efficiency for Fe3+ and Zn2+, and lower efficiency for Pb2+, Ni2+, and Cd2+, and poor efficiency for Mn2+ ions. In Conclusion,: SG-dpm exhibits promising potential for selective UO2 2+ ion removal, demonstrating favorable characteristics for various applications, including environmental remediation and nuclear waste management.","PeriodicalId":10742,"journal":{"name":"Current Analytical Chemistry","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140561764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
: Biophysical techniques include various methodologies applied in studying biological systems at the molecular and cellular level for the drug discovery process. Various methods like isothermal calorimetry, electron microscopy, XRD (X-ray diffraction), electron microscopy, mass spectrometry, atomic force microscopy, differential scanning calorimetry, surface plasmon resonance, and nuclear magnetic resonance are important techniques for drug discovery. Out of these techniques, XRD is widely employed in structure-based drug discovery, whereas FBDD (fragment-based drug discovery) is widely used in the different phases of drug discovery. XRD was considered one of the most important tools for structure determination of biomolecules and peptides. Consistent development and advancement in XRD improved the various aspects of data processing, collection, sample loading, and increased throughput. This advancement is crucial in obtaining highly resolved protein and other biomolecule crystal structures. The structure obtained from XRD forms the core of structure-based drug discovery and FBDD. This review article focuses on the different roles of biophysical techniques with special emphasis on advancement, data collection, and XRD's role in different drug discovery phases.
{"title":"Practical Perspectives and Roles of XRD in Drug Discovery: A Review","authors":"Ashish Mehta, Rahul Makhija, Pallavi Barik, Shubham Dhiman, Ghanshyam Das Gupta, Vivek Asati","doi":"10.2174/0115734110296435240323113938","DOIUrl":"https://doi.org/10.2174/0115734110296435240323113938","url":null,"abstract":": Biophysical techniques include various methodologies applied in studying biological systems at the molecular and cellular level for the drug discovery process. Various methods like isothermal calorimetry, electron microscopy, XRD (X-ray diffraction), electron microscopy, mass spectrometry, atomic force microscopy, differential scanning calorimetry, surface plasmon resonance, and nuclear magnetic resonance are important techniques for drug discovery. Out of these techniques, XRD is widely employed in structure-based drug discovery, whereas FBDD (fragment-based drug discovery) is widely used in the different phases of drug discovery. XRD was considered one of the most important tools for structure determination of biomolecules and peptides. Consistent development and advancement in XRD improved the various aspects of data processing, collection, sample loading, and increased throughput. This advancement is crucial in obtaining highly resolved protein and other biomolecule crystal structures. The structure obtained from XRD forms the core of structure-based drug discovery and FBDD. This review article focuses on the different roles of biophysical techniques with special emphasis on advancement, data collection, and XRD's role in different drug discovery phases.","PeriodicalId":10742,"journal":{"name":"Current Analytical Chemistry","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140561821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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