Current Developments in Nutrition最新文献

{"title":"Food Waste among Young Adults: Behaviors, Barriers, and Opportunities for Intervention","authors":"Sara E Vandersip ,&nbsp;Lindsey Smith Taillie ,&nbsp;Anna H Grummon ,&nbsp;Carmen E Prestemon ,&nbsp;Alexandria E Reimold","doi":"10.1016/j.cdnut.2025.107541","DOIUrl":"10.1016/j.cdnut.2025.107541","url":null,"abstract":"<div><h3>Background</h3><div>Reducing food waste is critical for protecting planetary and human health. Given that young adulthood is often a formative period for learning food management skills, young adults are a key demographic to study to better understand and intervene on food waste-related behaviors.</div></div><div><h3>Objectives</h3><div>To describe food waste behaviors and barriers to reducing food waste among young adults.</div></div><div><h3>Methods</h3><div>A cross-sectional online survey with a convenience sample (<em>n</em> = 2132) of United States young adults was conducted between November 2023 and December 2023. The survey measured self-reported food waste, difficulty reducing food waste, food waste-related behaviors, perceptions, intentions, and sociodemographic characteristics using items adapted from previous studies. Logistic regression was used to examine correlates of food waste.</div></div><div><h3>Results</h3><div>Roughly 1-quarter (26%) of participants reported high food waste (≥30% of food wasted). Three-quarters of participants (77%) reported concern with food waste, and half (45%) reported being likely to reduce their food waste in the next 30 days. Non-Hispanic Black participants reported higher food waste than non-Hispanic White participants, whereas participants meeting financial needs with a little left over reported less food waste than those reporting comfortable financial situations (all <em>P</em> &lt; 0.05). Barriers to reducing food waste included the inability to save food for later (25%), limited motivation to avoid food waste (18%), and not knowing how to avoid food waste (17%).</div></div><div><h3>Conclusions</h3><div>Food waste varied by race and perceived financial situation. Barriers to reducing food waste could be addressed with environmental interventions that make it easier to save food for later and educational campaigns on why and how to reduce food waste.</div></div>","PeriodicalId":10756,"journal":{"name":"Current Developments in Nutrition","volume":"9 10","pages":"Article 107541"},"PeriodicalIF":3.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145263392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Micronutrient Biomarker Selection and Assay Methods and Performance in Double-Blind, Randomized, Controlled Micronutrient Dose Response (MiNDR) Trials among Women of Reproductive Age and Pregnant Women in Rural Bangladesh","authors":"Sulagna Bandyopadhyay ,&nbsp;Anjan Kumar Roy ,&nbsp;Sarah Baker ,&nbsp;Katherine K. Stephenson ,&nbsp;Ximing Ge ,&nbsp;Yuwei Wang ,&nbsp;Khalid Bin Ahsan ,&nbsp;Eleonor Zavala ,&nbsp;Hasmot Ali ,&nbsp;Rezwanul Haque ,&nbsp;Lee Shu Fune Wu ,&nbsp;Brooke Langevin ,&nbsp;Mathangi Gopalakrishnan ,&nbsp;Towfida Jahan Siddiqua ,&nbsp;S.M. Tafsir Hasan ,&nbsp;Parul Christian ,&nbsp;Kerry J Schulze","doi":"10.1016/j.cdnut.2025.107546","DOIUrl":"10.1016/j.cdnut.2025.107546","url":null,"abstract":"<div><h3>Background</h3><div>Comprehensive documentation of micronutrient biomarker assessments, capturing status from deficiency to excess, remains limited, specifically in the context of multiple micronutrient supplementation (MMS) trials.</div></div><div><h3>Objectives</h3><div>We document biomarker selection, preanalytical and analytical methods, assay performance evaluation, and biomarker interpretation for modeling the dose–response effects of MMS in 2 parallel bioefficacy trials among women of reproductive age and pregnant women in rural Bangladesh.</div></div><div><h3>Methods</h3><div>Blinded analysis of biomarker assays is being performed in the field and at 2 laboratories. Automated clinical chemistry analyzers are used to measure conventional serum and plasma biomarkers of vitamin D, B12, folate, iron, inflammation, iodine, and bone turnover. Plasma vitamers of A, E, B2, and B6, and urinary B1, B2, and B3 are measured by ultra-performance liquid chromatography (UPLC). A serum mineral panel is analyzed by inductively coupled plasma mass spectrometry (ICP-MS). Urinary iodine and functional assays for vitamin B1, B2, and B12, iron, and selenium are measured using 96-well plate methods. Point-of-care tests are performed for hemoglobin in venous blood, whereas liver and kidney function, glucose, and a lipid panel are performed in plasma.</div></div><div><h3>Results</h3><div>Limits of detection and quantitation for biomarker assays are reported. Interassay coefficient of variations of quality control (QC) materials for primary outcome biomarkers are 4%–10% for automated analyzers, ICP-MS, and 96-well plate, and 2%–11% for UPLC assays, where available. Measurements of two-thirds of the primary outcome biomarkers could be evaluated using established external QC materials to ensure assay performance.</div></div><div><h3>Conclusions</h3><div>The detailed account of micronutrient biomarker assays in the dose–response MMS trials provides a useful framework for designing future research involving comprehensive assessments of micronutrient status in vulnerable populations. External quality assurance tools are warranted for UPLC-based B1, B2, and B3 vitamers, and for kinetic assays of B1, B2, and selenium.</div></div>","PeriodicalId":10756,"journal":{"name":"Current Developments in Nutrition","volume":"9 10","pages":"Article 107546"},"PeriodicalIF":3.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145325771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Invitation for Nominations for 2026","authors":"","doi":"10.1016/j.cdnut.2025.107586","DOIUrl":"10.1016/j.cdnut.2025.107586","url":null,"abstract":"","PeriodicalId":10756,"journal":{"name":"Current Developments in Nutrition","volume":"9 10","pages":"Article 107586"},"PeriodicalIF":3.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145412572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Effects of Dietary Intake on Gut Microbiome Diversity and Composition of Older Adults with Type 1 Diabetes: A Pilot Study","authors":"Aastha S Dubal ,&nbsp;Angelica Cristello Sarteau ,&nbsp;Maria Andrea Azcarate-Peril ,&nbsp;Zorka Djukic ,&nbsp;Gabriella Ercolino ,&nbsp;Angela Fruik ,&nbsp;Julia Ho ,&nbsp;Zoe Lee ,&nbsp;Jeffrey Roach ,&nbsp;Michael Valancius ,&nbsp;Laura A Young ,&nbsp;Ian M Carroll ,&nbsp;Anna R Kahkoska","doi":"10.1016/j.cdnut.2025.107550","DOIUrl":"10.1016/j.cdnut.2025.107550","url":null,"abstract":"<div><h3>Background</h3><div>Gut microbiome diversity and composition have been associated with type 1 diabetes (T1D) onset and progression. These features have not been explored among the growing number of older adults with T1D, including how they may differ by diet.</div></div><div><h3>Objectives</h3><div>In the present observational study, we investigated differences in gut microbiome diversity and composition across quantiles of high and low macronutrient, fiber, and simple sugar intake.</div></div><div><h3>Methods</h3><div>We collected observational data on routine diabetes management, diet, and other health indicators from older adults with T1D over 7–9 d, including 2 24-h dietary recall interviews, diabetes technology, and medical record data. Stool samples were collected for gut microbiome characterization using high-throughput sequencing of the 16S ribosomal RNA gene. Gut microbiome characteristics were assessed by Analysis of Compositions of Microbiomes with Bias Correction (ANCOM-BC2), Shannon index, and Bray–Curtis distances.</div></div><div><h3>Results</h3><div>Among 17 older adults [mean (SD) age 73.5 (6.2) y; diabetes duration: 34.0 (16.0) y, and glycated hemoglobin: 7.0 (0.9) %], increased fat intake was associated with enriched genus <em>Lactococcus</em>, increased fiber intake was associated with enriched genus <em>Hemophilus</em> and unclassified <em>Clostridium</em> within family <em>CAG:508</em>, and increased fructose intake was associated with enrichment of unclassified genus <em>SFMI01</em> within family <em>Christensenellaceae</em>. Greater carbohydrate intake was associated with depletion of the family <em>Enterobacteriaceae</em>. Microbial diversity differed significantly with greater fiber and fructose intake.</div></div><div><h3>Conclusions</h3><div>We found statistically significant evidence suggesting that the gut microbiome of older adults with T1D may be modulated by macronutrient, fiber, and fructose intake. Similar trends between fiber intake differences and significantly different microbial community structure have been found in younger populations. Together with the literature, our other findings suggest that macronutrient, fiber, and fructose intakes may impact the gut microbiome differently in older adults with T1D.</div></div>","PeriodicalId":10756,"journal":{"name":"Current Developments in Nutrition","volume":"9 10","pages":"Article 107550"},"PeriodicalIF":3.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145263393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Hitchhiker Story? Exploring HDL as an Overlooked Vitamin D Carrier","authors":"Jennifer D Bean,&nbsp;Catherine A Peterson","doi":"10.1016/j.cdnut.2025.107499","DOIUrl":"10.1016/j.cdnut.2025.107499","url":null,"abstract":"<div><h3>Background</h3><div>Twenty-five-hydroxyvitamin D, used to assess vitamin status, is the primary circulating form of vitamin D having a half-life measured in weeks, and 1,25-dihydroxyvitamin D is the active metabolite having a half-life measured in hours. Although there has been a preponderance of research on the roles of the active metabolite in health, there remains a limited understanding of the transport of the true vitamin forms, ergocalciferol and cholecalciferol.</div></div><div><h3>Objective</h3><div>This study proposes an alternative mechanism for vitamin D transport, hypothesizing that high-density lipoprotein (HDL) facilitates its movement from the intestine to the liver using cholesterol transporters.</div></div><div><h3>Methods</h3><div>This perspective challenges the sole reliance on the classical chylomicron pathway, proposing an alternative mechanism based on vitamin D's striking structural similarity to cholesterol. Both are steroids sharing key features, suggesting analogous intestinal absorption and transport routes. Evidence indicates vitamin D utilizes known enteric cholesterol transporters for uptake. We hypothesize that high-density lipoprotein (HDL) functions as an important interorgan carrier, facilitating vitamin D's movement from the intestine to the liver, using shared cholesterol transporters. This proposed HDL-mediated delivery is particularly relevant given vitamin D-binding protein's lower affinity for vitamin D compared with 25-hydroxyvitamin D.</div></div><div><h3>Results</h3><div>This mechanism offers a plausible explanation for observed correlations between vitamin D status (plasma 25-hydroxyvitamin D concentrations) and factors affecting HDL cholesterol concentration (HDLc). Modulators that increase HDLc (e.g., fibrates, oral contraceptives, and exercise) are associated with improved vitamin D status, whereas those that decrease HDLc or inhibit vitamin D absorption (e.g., smoking and ezetimibe) are linked to lower vitamin D status. Although current human data are largely correlative and confounded by numerous factors affecting vitamin D status, the consistent associations warrant further investigation into vitamin D’s precise trafficking among lipoprotein fractions.</div></div><div><h3>Conclusions</h3><div>Re-evaluating vitamin D’s absorption and transport to include a role for HDL holds implications for optimizing vitamin D status.</div></div>","PeriodicalId":10756,"journal":{"name":"Current Developments in Nutrition","volume":"9 10","pages":"Article 107499"},"PeriodicalIF":3.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145263391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current Guidelines on Dietary Protein Intake for Patients with Diabetic Kidney Disease: A Scoping Review","authors":"Siyanga Ravi,&nbsp;Alexandra Fahrner,&nbsp;Frank Rühli,&nbsp;Nicole Bender","doi":"10.1016/j.cdnut.2025.107551","DOIUrl":"10.1016/j.cdnut.2025.107551","url":null,"abstract":"<div><h3>Background</h3><div>International nutritional guidelines vary in their recommendations, as well as in the reporting quality of the underlying evidence. An underreported recommendation in guidelines for people with type II diabetes concerns the optimal protein intake in the case of chronic kidney disease (CKD).</div></div><div><h3>Objectives</h3><div>In this review, we analyze the protein intake recommendations from worldwide practice guidelines for type II diabetes and CKD.</div></div><div><h3>Methods</h3><div>We conducted a systematic search in the online databases PubMed, Embase, and Cochrane Database of Systematic Reviews, as well as websites, according to Preferred Reporting Items for Systematic reviews and Meta-Analyses guidelines, and up to 31 January, 2023. We included nutritional and clinical practice guidelines on protein intake in patients with type II diabetes and CKD of different stages. We assessed the quality of the guidelines using the instruments Appraisal of Guidelines for Research &amp; Evaluation Instrument (AGREE II) and AGREE Recommendation Excellence. We assessed the quality of the underlying scientific evidence using the evidence pyramid and the level of evidence categorization.</div></div><div><h3>Results</h3><div>Of 24 included guidelines, 5 met the quality assessment of all instruments. Their evidence was based on an overlapping number of randomized controlled trials (RCTs). Nevertheless, their protein intake recommendations differed, ranging from no restriction to restriction to 0.8 g/kg body weight/d.</div></div><div><h3>Conclusions</h3><div>The reason for the discrepancy of protein intake recommendations between different guidelines could not be determined conclusively, as the methodology of evidence assessment was often insufficiently reported. More long-term and good-quality RCTs are needed. We recommend the use of rigorous development and quality assessment tools in the development of clinical practice guidelines for patients with CKD and type II diabetes.</div></div>","PeriodicalId":10756,"journal":{"name":"Current Developments in Nutrition","volume":"9 10","pages":"Article 107551"},"PeriodicalIF":3.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145263396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Beyond Hunger: Uncovering the Link between Food Insecurity and Depression, Anxiety, and Stress in Adolescents [Current Developments in Nutrition 9 (2025) 107453]","authors":"Emily Cisneros-Vásquez ,&nbsp;Lee Smith ,&nbsp;Rodrigo Yañéz-Sepúlveda ,&nbsp;Jorge Olivares-Arancibia ,&nbsp;Héctor Gutiérrez-Espinoza ,&nbsp;Dong Keon Yon ,&nbsp;Jae Il Shin ,&nbsp;José Francisco López-Gil","doi":"10.1016/j.cdnut.2025.107570","DOIUrl":"10.1016/j.cdnut.2025.107570","url":null,"abstract":"","PeriodicalId":10756,"journal":{"name":"Current Developments in Nutrition","volume":"9 10","pages":"Article 107570"},"PeriodicalIF":3.2,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145326389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Federal Nutrition Assistance Programs and UltraProcessed Food Intake among Preschool-Aged Children","authors":"Ashley Drengler ,&nbsp;Evan C Sommer ,&nbsp;Nadia M Sneed ,&nbsp;Ellen McMahon ,&nbsp;Kimberly P Truesdale ,&nbsp;Donna Matheson ,&nbsp;Tracy E Noerper ,&nbsp;Lauren R Samuels ,&nbsp;Shari L Barkin ,&nbsp;William J Heerman","doi":"10.1016/j.cdnut.2025.107564","DOIUrl":"10.1016/j.cdnut.2025.107564","url":null,"abstract":"<div><h3>Background</h3><div>Among children in the United States, ultraprocessed foods (UPFs) account for ∼67% of daily calories, reflecting a low-quality diet. Among low-income preschool-aged children whose families participate in the Supplemental Nutrition Assistance Program (SNAP) or Special Supplemental Nutrition Program for Women, Infants, and Children (WIC), UPF consumption patterns have been understudied.</div></div><div><h3>Objectives</h3><div>This study evaluated the association between SNAP and/or WIC enrollment and child UPF consumption and characterized the relationship between SNAP and WIC participation, food insecurity, and UPF intake among low-income, preschool-aged children.</div></div><div><h3>Methods</h3><div>We conducted a secondary cohort analysis of an RCT for childhood obesity prevention that enrolled 610 predominantly Latino parent-child pairs from low-income families. The exposure was baseline participation in SNAP only, WIC only, both, or neither. The outcome was percentage of child caloric intake from UPFs. A linear mixed-effects model assessed the relationship between baseline assistance program participation and UPF intake over time, adjusting for sociodemographic covariates.</div></div><div><h3>Results</h3><div>Among 582 eligible participants, median child age at baseline was 4.3 y (Q1, 3.6 y; Q3, 5.0 y); 91.4% (<em>n</em> = 532) of parents identified as Latino, 55.8% (<em>n</em> = 325) had household income &lt;$25,000/y, and 42.8% (<em>n</em> = 249) had food insecurity. Approximately 21% (<em>n</em> = 124) of families used SNAP only, 12% (<em>n</em> = 68) of families used WIC only, and 54% (<em>n</em> = 316) used both. Median caloric intake of UPFs was 62.5% (Q1, 53.1%; Q3, 71.0%) at baseline. Neither assistance program use nor the interaction between assistance program use and household food insecurity was statistically significantly related to UPF intake.</div></div><div><h3>Conclusions</h3><div>Among predominantly Latino preschoolers from low-income families, UPF intake is high (&gt;60% of calories). The percentage of caloric intake from UPFs does not significantly differ by SNAP and/or WIC participation, regardless of food insecurity status.</div><div>This trial was registered at <span><span>clinicaltrials.gov</span><svg><path></path></svg></span> as NCT01316653.</div></div>","PeriodicalId":10756,"journal":{"name":"Current Developments in Nutrition","volume":"9 11","pages":"Article 107564"},"PeriodicalIF":3.2,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145340921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sumac (Rhus coriaria L.) Supplementation on High-Sensitivity C-Reactive Protein Concentrations in Adults: A Systematic Review and Dose-Response Meta-Analysis","authors":"Mostafa Shahraki Jazinaki ,&nbsp;Hossein Bahari ,&nbsp;Iman Rahnama ,&nbsp;Mohammad Safarian ,&nbsp;Mahsa Malekahmadi","doi":"10.1016/j.cdnut.2025.107555","DOIUrl":"10.1016/j.cdnut.2025.107555","url":null,"abstract":"<div><h3>Background</h3><div>Chronic low-grade inflammation is implicated in the development of various metabolic and cardiovascular disorders. Sumac (<em>Rhus coriaria</em> L.) is a medicinal plant with potential anti-inflammatory properties. However, the effects of sumac supplementation on inflammatory biomarkers, particularly high-sensitivity C-reactive protein (hs-CRP), remain controversial.</div></div><div><h3>Objectives</h3><div>This systematic review and meta-analysis aimed to evaluate the effect of sumac supplementation on hs-CRP concentrations in adults.</div></div><div><h3>Methods</h3><div>A systematic search was performed in PubMed, Scopus, Web of Science, and the Cochrane Library databases up to February 2025 to identify RCTs examining the impact of sumac supplementation on hs-CRP concentrations. Screening, data extraction, and risk of bias assessment were conducted independently. A random-effects model was used to calculate the overall effect size as the SMD with 95% CIs.</div></div><div><h3>Results</h3><div>Seven RCTs were eligible for inclusion in this review. The pooled analysis demonstrated a significant reduction in hs-CRP concentrations following sumac supplementation compared with that in the control groups (SMD: −0.33; 95% CI: −0.64, −0.02; <em>P</em> = 0.03). Moreover, a significant heterogeneity was detected among the pooled effect sizes (<em>P</em> = 0.02; <em>I</em>² = 60.2%). Subgroup analyses revealed that sumac supplementation led to a significant reduction in hs-CRP concentrations in trials that included both genders or in studies conducted on patients with nonalcoholic fatty liver disease, individuals with overweight, or those aged ≥45 y.</div></div><div><h3>Conclusions</h3><div>Sumac supplementation may significantly reduce hs-CRP concentrations in adults. Further high-quality, large-scale trials in various populations in terms of areas or health conditions are required to confirm these findings and determine the optimal dosage and duration for sumac supplementation to reduce inflammation.</div><div>This trial is registered at PROSPERO database as CRD420251016622.</div></div>","PeriodicalId":10756,"journal":{"name":"Current Developments in Nutrition","volume":"9 10","pages":"Article 107555"},"PeriodicalIF":3.2,"publicationDate":"2025-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145156744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship Between Blood Lipidomics and Cardiotoxic Injury Following Acute Exposure to Anthracycline Chemotherapy in Women With Breast Cancer: A Feasibility Study","authors":"Kate E Marris ,&nbsp;Rachel M Cole ,&nbsp;Daniel Addison ,&nbsp;Patrick Ruz ,&nbsp;Genevieve Sparagna ,&nbsp;Ai Ni ,&nbsp;Martha A Belury","doi":"10.1016/j.cdnut.2025.107552","DOIUrl":"10.1016/j.cdnut.2025.107552","url":null,"abstract":"<div><h3>Background</h3><div>Anthracycline chemotherapy (AC) leads to cardiotoxicity in many patients with breast cancer by inducing inner mitochondrial damage and disrupting the electron transport chain. It is unclear why some, but not all, women who undergo AC develop chronic cardiac dysfunction.</div></div><div><h3>Objectives</h3><div>The aim of this prospective feasibility study was to determine accrual rate and estimate the effect size of 1 cycle of AC on myocardial injury and blood lipidome changes in women with breast cancer.</div></div><div><h3>Methods</h3><div>Fourteen women with breast cancer planning to undergo AC enrolled and underwent cardiac magnetic resonance (CMR) imaging and blood sampling across 2 visits, before and after any 1 cycle of AC in the treatment regimen. Fatty acid composition of red blood cells (RBCs) and cardiolipin (CL) in peripheral blood mononuclear cells were measured. Exploratory analyses were conducted.</div></div><div><h3>Results</h3><div>Myocardial edema, obtained via T2 mapping using CMR, increased after 1 cycle of AC in women with breast cancer. The ratio of tetralinoleoyl (LA₄) to tetraoleoyl (OA₄) CL correlated negatively with myocardial fibrosis, obtained via T1 mapping using CMR. OA₄CL correlated positively with myocardial fibrosis, and OA content in RBCs correlated positively with myocardial edema.</div></div><div><h3>Conclusions</h3><div>OA₄CL and OA in RBCs appear to be related to subclinical markers of cardiotoxicity in women with breast cancer undergoing AC. Larger studies are needed to investigate potential cardioprotective effects of dietary linoleic acid and LA₄CL against AC.</div><div>This trial was registered at <span><span>clinicaltrials.gov</span><svg><path></path></svg></span> as NCT03961685</div></div>","PeriodicalId":10756,"journal":{"name":"Current Developments in Nutrition","volume":"9 10","pages":"Article 107552"},"PeriodicalIF":3.2,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145156809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}