Cortex最新文献

{"title":"Speech perception and language comprehension in primary progressive aphasia","authors":"Heather R. Dial ,&nbsp;Rachel Tessmer ,&nbsp;Maya L. Henry","doi":"10.1016/j.cortex.2024.10.010","DOIUrl":"10.1016/j.cortex.2024.10.010","url":null,"abstract":"<div><div>Primary progressive aphasia (PPA) is a neurodegenerative disorder characterized by progressive loss of speech and language. Although speech perception and language comprehension deficits are observed in individuals with PPA, these deficits have been understudied relative to production deficits. Recent work has examined receptive language processing at sublexical, lexical, and semantic levels in PPA; however, systematic investigation of these levels of processing within a single PPA cohort is lacking. The current study sought to fill this gap. Individuals with logopenic, nonfluent, and semantic variants of PPA and healthy, age-matched controls completed minimal pairs syllable discrimination, auditory lexical decision, and picture-word verification tasks to assess sublexical, lexical, and semantic processing. Distinct profiles were observed across PPA variants. Individuals with logopenic variant PPA had impaired performance on auditory lexical decision and picture-word verification tasks, with a trend toward impaired performance on the syllable discrimination task. Individuals with nonfluent and semantic variant PPA had impaired performance only on auditory lexical decision and picture-word verification. Evaluation of the types of errors made on the picture-word verification task (phonological and semantic) provided further insight into levels of deficits across the variants. Overall, the results indicate deficits in receptive processing at the lexical-phonological, lexical-semantic, and semantic levels in logopenic variant PPA, with a trend toward impaired sublexical processing. Deficits were observed at the lexical-semantic and semantic levels in semantic variant PPA, and lexical-phonological deficits were observed in nonfluent PPA, likely reflecting changes both in lexical-phonological processing as well as changes in predictive coding during perception. This study provides a more precise characterization of the linguistic profile of each PPA subtype for speech perception and language comprehension. The constellation of deficits observed in each PPA subtype holds promise for differential diagnosis and for informing models of intervention.</div></div>","PeriodicalId":10758,"journal":{"name":"Cortex","volume":"181 ","pages":"Pages 272-289"},"PeriodicalIF":3.2,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142692302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do total hippocampus and hippocampal subfield volumes relate to navigation ability? A call towards methodological consistency","authors":"Alina S. Tu,&nbsp;Nicholas A. Krohn,&nbsp;Olivia C. Cooper,&nbsp;Vaisakh Puthusseryppady,&nbsp;Caitlin McIntyre,&nbsp;Elizabeth R. Chrastil","doi":"10.1016/j.cortex.2024.08.011","DOIUrl":"10.1016/j.cortex.2024.08.011","url":null,"abstract":"<div><div>Despite the need for successful navigation, humans vary greatly in their ability to navigate, and these individual differences may relate to variation in brain structure. While prior research provides support for a correlation between hippocampal volume and navigation ability in both navigation experts and in older individuals, this relationship is under scrutiny for healthy, young adults. We assessed 99 healthy young adults' ability to navigate in a virtual, desktop maze and correlated their performance with total hippocampal gray matter volume. For a subset of these individuals, we further segmented the medial temporal lobe—including regions of the hippocampus—into anatomically-distinct subregions to uniquely examine the association between volumes of hippocampal subfields and navigation. Given the need to distinguish between similar-looking maze hallways and partially overlapping routes, young adults with stronger pattern separation ability may perform better in this task. Thus, we theorized that successful navigation would positively correlate with hippocampal CA3 and dentate gyrus (DG) subfield volumes due to these regions' role in pattern separation. CA1 and entorhinal cortex (ERC) are both associated with rodent spatial memory, too, suggesting a possible relationship between their volumes and navigation performance. Consistent with our hypotheses, we observed a positive relationship between volumes of hippocampal subfields and wayfinding accuracy, while ERC and parahippocampal cortex volumes correlated with navigation efficiency. However, when analyzing total hippocampal volume, a nuanced interpretation is warranted. We found evidence of Simpson's Paradox, where total hippocampal volume and navigation accuracy displayed no correlation in males, a negative correlation in females, yet a positive correlation when considering the full sample of males and females combined. Furthermore, no significant relationship was observed between total hippocampal volume and path efficiency. Given these findings, we urge caution in interpreting the results because these associations differ by analysis techniques (including voxel-based morphometry), after sex stratification, and with anterior and posterior hippocampal subdivisions. Overall, this study enhances our understanding of the relationship between brain volume and navigation ability for young adults but also emphasizes the need for methodological consistency across studies with respect to boundary definitions, neuroimaging techniques, statistical methods, and factors that give rise to individual differences.</div></div>","PeriodicalId":10758,"journal":{"name":"Cortex","volume":"181 ","pages":"Pages 233-257"},"PeriodicalIF":3.2,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142681269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Following in Luria's footsteps: The first training booklet for the neuropsychological assessment of patients with brain lesions.","authors":"Marco Catani, Luciano Mecacci","doi":"10.1016/j.cortex.2024.10.006","DOIUrl":"https://doi.org/10.1016/j.cortex.2024.10.006","url":null,"abstract":"","PeriodicalId":10758,"journal":{"name":"Cortex","volume":"183 ","pages":"146-166"},"PeriodicalIF":3.2,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vertical neglect towards the lower space after bilateral parietal strokes – A case study","authors":"Noëlle Schwendinger ,&nbsp;Brigitte Charlotte Kaufmann ,&nbsp;Dario Cazzoli ,&nbsp;Thomas Nyffeler","doi":"10.1016/j.cortex.2024.10.012","DOIUrl":"10.1016/j.cortex.2024.10.012","url":null,"abstract":"<div><div>While considerable knowledge has been acquired concerning the involvement of the parietal cortex in <em>horizontal</em> visuo-spatial attention, the understanding of its specific contribution to the <em>vertical</em> dimension remains limited. Here we present the exceptional case of a patient, who suffered from two consecutive ischemic strokes at the same location within the left and right Middle Cerebral Artery (MCA) territory, involving the superior parietal lobule, the supramarginal gyrus, and the angular gyrus. While the first left-hemispheric stroke led to a right-sided neglect, the consecutive stroke in the right hemisphere led to a left-sided neglect. In both cases, the horizontal visuo-spatial attentional bias resolved after a short time period. However, after the second stroke, the patient displayed a notable manifestation of vertical neglect for the right and the left lower visual space, as shown by means of a neuropsychological assessment with the Sensitive Neglect Test. Furthermore, video-oculography during Free Visual Exploration (FVE), comparing the patient’s exploration behaviour against twenty age-matched healthy controls, confirmed the significant visuo-spatial attentional deficits for the lower visual space. In conclusion, the present case study illustrates that the parietal cortex controls visuo-spatial attention deployment towards the contralateral and, more prominently, towards the lower visual space. Therefore, the clinical evaluation of neglect symptoms should also take the vertical dimension into account.</div></div>","PeriodicalId":10758,"journal":{"name":"Cortex","volume":"181 ","pages":"Pages 155-164"},"PeriodicalIF":3.2,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142638637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diminished sense of agency inhibits paretic upper-limb use in patients with post-stroke motor deficits","authors":"Yu Miyawaki ,&nbsp;Takeshi Otani ,&nbsp;Masaki Yamamoto ,&nbsp;Shu Morioka ,&nbsp;Akihiko Murai","doi":"10.1016/j.cortex.2024.10.009","DOIUrl":"10.1016/j.cortex.2024.10.009","url":null,"abstract":"<div><div>Post-stroke motor deficits often disrupt the voluntary control of body movements, leading to abnormal feelings. Among these, alterations in the sense of agency (SoA), the feeling of controlling one’s movement, are notable because SoA facilitates actions. However, whether patients with more severe motor deficits experience poorer SoA and SoA’s clinical impact on motor activity remain unclear. To address these questions, this longitudinal study quantified SoA in 156 post-stroke patients through factor analyses with multiple question items to differentiate SoA from potentially confounding discomfort. Structural equation modeling revealed that SoA decreased significantly with upper-limb motor deficit severity and that reduced SoA correlated significantly with decreased paretic upper-limb use. Notably, this effect persisted after controlling for motor deficit severity, suggesting a direct clinical impact of SoA on motor activity. Further, improvements in SoA were significantly associated with increased upper-limb use in patients with moderate or severe motor deficits, emphasizing the role of SoA in maintaining or increasing paretic upper-limb activity. These findings highlight the importance of rehabilitation treatments that consider patients' subjective experiences, particularly agency attribution.</div></div>","PeriodicalId":10758,"journal":{"name":"Cortex","volume":"181 ","pages":"Pages 165-178"},"PeriodicalIF":3.2,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142643441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outgroup homogeneity perception as a precursor to the generalization of threat across racial outgroup individuals","authors":"Niclas Willscheid,&nbsp;Florian Bublatzky","doi":"10.1016/j.cortex.2024.09.017","DOIUrl":"10.1016/j.cortex.2024.09.017","url":null,"abstract":"<div><div>People who look different from oneself are often categorized as homogeneous members of another racial group. We examined whether the relationship between such categorization and the tendency to generalize across outgroup individuals is explained by perceived visual similarity, leading to an all-look-alike misperception. To address this question at the neural level, White participants perceived sequences of White and Black faces while event-related electrocortical activity was recorded. Prior to each face sequence, one specific ingroup or outgroup face was instructed as a cue for receiving unpleasant electric shocks (threat cue), and we were interested in the extent to which such threat effects generalize to other non-instructed faces (safety cues). Face stimuli were presented in adaptor-target pairs, consisting of two ingroup faces or two outgroup faces, which could depict either the same or different identities. Results show less identity processing of outgroup compared to ingroup faces in early visual processing, i.e., N170 repetition suppression was sensitive only to ingroup face identities. Subsequently, as indicated by enhanced Late Positive Potentials to both threat and safety faces, instructed threat generalized stronger across outgroup compared to ingroup faces. These findings and their interaction suggest that the misperception of outgroup homogeneity may be an early precursor to the tendency to generalize threat associations across outgroup individuals.</div></div>","PeriodicalId":10758,"journal":{"name":"Cortex","volume":"181 ","pages":"Pages 258-271"},"PeriodicalIF":3.2,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142686353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EEG frequency tagging reveals the integration of dissimilar observed actions","authors":"Silvia Formica ,&nbsp;Anna Chaiken ,&nbsp;Jan R. Wiersema ,&nbsp;Emiel Cracco","doi":"10.1016/j.cortex.2024.10.015","DOIUrl":"10.1016/j.cortex.2024.10.015","url":null,"abstract":"<div><div>Extensive research has demonstrated that visual and motor cortices can simultaneously represent multiple observed actions. This ability undoubtedly constitutes a crucial ingredient for the understanding of complex visual scenes involving different agents. However, it is still unclear how these distinct representations are integrated into coherent and meaningful percepts. In line with studies of perceptual binding, we hypothesized that similar movements would be more easily integrated. To test this hypothesis, we developed an EEG frequency tagging experiment in which two hand movements were displayed simultaneously at two different presentation rates. Crucially, the degree of similarity between the two movements varied along two dimensions, namely action identity (i.e., same or different performed movement), and agent identity (i.e., one agent performing a bimanual movement, or two agents moving each one hand). Contrary to our predictions, we found a larger intermodulation oscillatory component, indexing the integrated processing of the two individual movements, when they were less similar. We propose that integration-by-dissimilarity might serve as a top-down process to solve conflict caused by incongruent movements, thus contributing to the global understanding of distinct moving individuals in a complex social scene.</div></div>","PeriodicalId":10758,"journal":{"name":"Cortex","volume":"181 ","pages":"Pages 204-215"},"PeriodicalIF":3.2,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142675111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cover figure","authors":"","doi":"10.1016/S0010-9452(24)00277-6","DOIUrl":"10.1016/S0010-9452(24)00277-6","url":null,"abstract":"","PeriodicalId":10758,"journal":{"name":"Cortex","volume":"180 ","pages":"Page e1"},"PeriodicalIF":3.2,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142573015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lack of visual experience leads to severe distortions in the hand representation of the body model","authors":"Srisai Rakesh Kottu,&nbsp;Leslee Lazar","doi":"10.1016/j.cortex.2024.09.015","DOIUrl":"10.1016/j.cortex.2024.09.015","url":null,"abstract":"<div><div>This study investigates the impact of vision on the maintenance of hand representation in the implicit body model, particularly focusing on congenitally blind individuals. To address this, we performed a hand landmark localization task on blind individuals who lacked visual experience of their bodies and compared their performance to normally sighted and normally sighted but blindfolded participants. Through measurements of finger lengths, hand width, and shape index, we demonstrate that blind participants exhibit significantly greater distortions in their hand representation compared to sighted and blindfolded controls. Notably, blind individuals displayed a marked overestimation of hand width and an underestimation of finger lengths, particularly in digits D2, D3, and D4. Surprisingly, blind subjects with partial vision displayed more severe distortions than those with no residual vision. Furthermore, our findings reveal that late-blind participants exhibit similar levels of distortion as congenitally blind individuals, suggesting an extended period of susceptibility to the lack of visual input in shaping body representations. The Reverse Distortion (RD) hypothesis provides a plausible explanation for these distortions, suggesting that compensatory mechanisms occur within the body model to counteract the anisotropic cortical representations. Our results support this hypothesis: blind individuals have expanded cortical representations processing tactile information, so this could lead to more pronounced distortions in their hand representation of the body model. This underscores the importance of visual input in modulating body representations. Overall, our study highlights the malleability of body representations and the intricate interplay between sensory inputs and cortical processing in shaping the implicit body model.</div></div>","PeriodicalId":10758,"journal":{"name":"Cortex","volume":"183 ","pages":"Pages 38-52"},"PeriodicalIF":3.2,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142745001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MEG evidence for left temporal and orbitofrontal involvement in breaking down inflected words and putting the pieces back together","authors":"Dave Kenneth Tayao Cayado ,&nbsp;Samantha Wray ,&nbsp;Dustin Alfonso Chacón ,&nbsp;Marco Chia-Ho Lai ,&nbsp;Suhail Matar ,&nbsp;Linnaea Stockall","doi":"10.1016/j.cortex.2024.08.010","DOIUrl":"10.1016/j.cortex.2024.08.010","url":null,"abstract":"<div><div>A major puzzle in the visual word recognition literature is how the human brain deals with complex words (e.g., <em>presuppose</em>). Prior work has shown that a multi-stage process is involved, starting with <span>the early, form-based decomposition stage</span> where a word is broken down into smaller pieces called morphemes {pre-}+{suppose} and ending with <span>the recombination stages</span> where the pieces are put back together to access the word’s full meaning. However, most neurolinguistic studies have focused on the first stage, and/or on derivational morphology, which inherently carries both syntactic and semantic information, and this research has overwhelmingly investigated Indo-European languages. Here, we investigate visual word recognition of Tagalog complex words, focusing on inflectional prefixes which allows us to zero in on the contribution of syntactic information during the recombination stage, where both syntactic and semantic information are expected to be analyzed. Using MEG, we replicate previous findings implicating the left fusiform gyrus in segmenting complex words into pieces. We also show that the recombination stages, where the morphological pieces are put back together, activate the left posterior temporal lobe and left orbitofrontal cortex. Although our results support a multi-stage comprehension model of complex words and confirm that these distinct stages are associated with distinct spatiotemporal profiles, we also observed some spatiotemporal differences compared to previous studies on derivational morphology. For the first time, we show that inflected words activate the same core processing profile as derived words in the early (decomposition) stage, while later (recombination) stages of morphological processing point to an earlier and faster recombination of inflected words.</div></div>","PeriodicalId":10758,"journal":{"name":"Cortex","volume":"181 ","pages":"Pages 101-118"},"PeriodicalIF":3.2,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142603475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}