Pub Date : 2024-07-11DOI: 10.2174/0115734137294302240625045852
Laila A. Elsayed, Abdullah M. Saif, Shrouk E. Elghol, Maha N. Zayed, Yomna M. Amin, Mohamed H. Omran, Mahmoud A. Ragab, Randa A. Althobiti, Gomaa A.M. Ali
: Cancer, claiming approximately 10 million lives annually, remains a leading cause of global mortality. Conventional cancer treatments, notably chemotherapy and radiotherapy, often entail adverse effects, such as cytotoxicity and the development of resistance, posing significant challenges in cancer management. While natural products have historically served medicinal purposes for various ailments, their recent prominence in combating cancer-related manifestations has surged. Utilizing natural products either alone as antineoplastic agents or in conjunction with conventional chemotherapies presents a promising approach to mitigate these adverse effects. The appeal of natural products lies in their accessibility, versatility, reduced cytotoxic potential, and capacity to counteract drug resistance. Various natural sources offer a diverse range of bioactive compounds capable of influencing various cancer types, modulating signaling pathways, and altering the cancer microenvironment. Notably, many bioactive compounds impact crucial cellular processes like metastasis, angiogenesis, metabolism, proliferation, and viability by targeting specific signaling pathways, particularly those involved in cellular apoptosis. Consequently, the modulation of these factors by natural products significantly affects cancer cell behavior. This comprehensive review explores the application of the promising phytoconstituents as anti-cancer agents across prevalent cancer types, including liver, lung, bladder, breast, leukemia, and colon cancer. In addition, it explores the anti-cancer properties of natural compounds, focusing on their mechanisms and effectiveness against diverse cancers, aiming to improve cancer management.
{"title":"A Comprehensive Review of Promising Phytoconstituents as Anti-Cancer Agents: Biological Mechanisms and Applications Across Different Cancers","authors":"Laila A. Elsayed, Abdullah M. Saif, Shrouk E. Elghol, Maha N. Zayed, Yomna M. Amin, Mohamed H. Omran, Mahmoud A. Ragab, Randa A. Althobiti, Gomaa A.M. Ali","doi":"10.2174/0115734137294302240625045852","DOIUrl":"https://doi.org/10.2174/0115734137294302240625045852","url":null,"abstract":": Cancer, claiming approximately 10 million lives annually, remains a leading cause of global mortality. Conventional cancer treatments, notably chemotherapy and radiotherapy, often entail adverse effects, such as cytotoxicity and the development of resistance, posing significant challenges in cancer management. While natural products have historically served medicinal purposes for various ailments, their recent prominence in combating cancer-related manifestations has surged. Utilizing natural products either alone as antineoplastic agents or in conjunction with conventional chemotherapies presents a promising approach to mitigate these adverse effects. The appeal of natural products lies in their accessibility, versatility, reduced cytotoxic potential, and capacity to counteract drug resistance. Various natural sources offer a diverse range of bioactive compounds capable of influencing various cancer types, modulating signaling pathways, and altering the cancer microenvironment. Notably, many bioactive compounds impact crucial cellular processes like metastasis, angiogenesis, metabolism, proliferation, and viability by targeting specific signaling pathways, particularly those involved in cellular apoptosis. Consequently, the modulation of these factors by natural products significantly affects cancer cell behavior. This comprehensive review explores the application of the promising phytoconstituents as anti-cancer agents across prevalent cancer types, including liver, lung, bladder, breast, leukemia, and colon cancer. In addition, it explores the anti-cancer properties of natural compounds, focusing on their mechanisms and effectiveness against diverse cancers, aiming to improve cancer management.","PeriodicalId":10827,"journal":{"name":"Current Nanoscience","volume":"39 1","pages":""},"PeriodicalIF":1.5,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141613253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Titanium Dioxide (TiO2) is popular in the scientific community due to its wide variety of applications in optoelectronic devices, solar cells, gas sensors, photocatalytic reagents, and the biomedical industry. It is a wide band gap semiconductor with a band gap of 3.2eV. Usually, it shows three different phases, like anatase, rutile, and brookite, based on the synthesis method and annealing temperature. Method: Here, we report a simple chemical process to synthesize TiO2 nanostructures (NSs) at low temperatures to study the impact of growth time on structural and morphological properties. During synthesis, we permitted the samples to grow for 5 hr (sample-T5) and 7 hr (sample-T7) and continued the stirring process accordingly. We performed XRD, UV-Vis, and FESEM analysis with the samples. Result: XRD confirmed the effect of growth time on the size of the structures, and a shift in the absorption edge was observed in UV-Vis spectra, which indicated a change in the band gap. FESEM confirmed the change in nanostructures’ size in both samples. Conclusion: The tuning in band gap due to growth time variation may be an interesting phenomenon to explore for modern scientific applications.
{"title":"Effect of Growth Time on Structural and Optical Properties of Chemically Synthesized TiO2 Nanostructures","authors":"Payal Paul, Dewakar Sharma, Joydeep Biswas, Kamakhya Prakash Misra, Sanjib Kabi, Saikat Chattopadhyay","doi":"10.2174/0115734137306442240630051459","DOIUrl":"https://doi.org/10.2174/0115734137306442240630051459","url":null,"abstract":"Introduction: Titanium Dioxide (TiO2) is popular in the scientific community due to its wide variety of applications in optoelectronic devices, solar cells, gas sensors, photocatalytic reagents, and the biomedical industry. It is a wide band gap semiconductor with a band gap of 3.2eV. Usually, it shows three different phases, like anatase, rutile, and brookite, based on the synthesis method and annealing temperature. Method: Here, we report a simple chemical process to synthesize TiO2 nanostructures (NSs) at low temperatures to study the impact of growth time on structural and morphological properties. During synthesis, we permitted the samples to grow for 5 hr (sample-T5) and 7 hr (sample-T7) and continued the stirring process accordingly. We performed XRD, UV-Vis, and FESEM analysis with the samples. Result: XRD confirmed the effect of growth time on the size of the structures, and a shift in the absorption edge was observed in UV-Vis spectra, which indicated a change in the band gap. FESEM confirmed the change in nanostructures’ size in both samples. Conclusion: The tuning in band gap due to growth time variation may be an interesting phenomenon to explore for modern scientific applications.","PeriodicalId":10827,"journal":{"name":"Current Nanoscience","volume":"32 1","pages":""},"PeriodicalIF":1.5,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141613309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: It has become essential to look into alternatives that effectively stop bacterial infections due to the exponential rise in antibiotic resistance. The field of nanotechnology has made significant strides in development by surmounting obstacles that have impeded success and advancement in other fields. Nanoparticles (NPs) are the key component in the burgeoning field of nanotechnology. Objective: Cyclamen libanoticum leaf extract (CLE) was used as a reducing and capping agent, with silver nitrate (AgNO3) solution as a precursor for synthesizing silver nanoparticles (CLEAgNPs). This study aimed to generate green silver nanoparticles (AgNPs) and assess their antioxidant and antibacterial capacities. Methods: CLE-AgNPs were characterized utilizing UV–vis spectrometry, X-ray diffraction (XRD), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), Fourier transform infrared spectroscopy (FTIR), and photoluminescence (PL). Using the radical scavenging assay 2,2-diphenyl-1-picrylhydrazyl (DPPH), the antioxidant activity of CLEAgNPs was evaluated. Several assays were employed to examine the antibacterial effect of CLE-AgNPs against various gram-positive and negative bacteria. Results: Upon analysis, the synthesis revealed 17 nm face-centered cubic CLE-AgNPs (λmax= 431 nm). CLE-AgNPs manifested noticeable antioxidant activity and prominent inhibitory effects on the tested bacteria. The minimum inhibitory concentration (MIC) of the CLE-AgNPs was 31.25 μg/mL for the eight bacterial species. Besides, the results revealed that CLE-AgNPs effectively suppressed the development of bacterial biofilms and could eradicate them. Conclusion: The present investigation introduced Cyclamen libanoticum as a novel bioresource into green chemistry to produce AgNPs with antibacterial and antioxidant capabilities.
{"title":"Cyclamen libanoticum is a Novel Bioresource for Green Silver Nanoparticles with Antibacterial and Antioxidant Capabilities","authors":"Zeinab Hachem, Rayan Kashmar, Alaa Abdallah, Ramadan Awad, Mahmoud Khalil","doi":"10.2174/0115734137310446240616164456","DOIUrl":"https://doi.org/10.2174/0115734137310446240616164456","url":null,"abstract":"Background: It has become essential to look into alternatives that effectively stop bacterial infections due to the exponential rise in antibiotic resistance. The field of nanotechnology has made significant strides in development by surmounting obstacles that have impeded success and advancement in other fields. Nanoparticles (NPs) are the key component in the burgeoning field of nanotechnology. Objective: Cyclamen libanoticum leaf extract (CLE) was used as a reducing and capping agent, with silver nitrate (AgNO3) solution as a precursor for synthesizing silver nanoparticles (CLEAgNPs). This study aimed to generate green silver nanoparticles (AgNPs) and assess their antioxidant and antibacterial capacities. Methods: CLE-AgNPs were characterized utilizing UV–vis spectrometry, X-ray diffraction (XRD), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), Fourier transform infrared spectroscopy (FTIR), and photoluminescence (PL). Using the radical scavenging assay 2,2-diphenyl-1-picrylhydrazyl (DPPH), the antioxidant activity of CLEAgNPs was evaluated. Several assays were employed to examine the antibacterial effect of CLE-AgNPs against various gram-positive and negative bacteria. Results: Upon analysis, the synthesis revealed 17 nm face-centered cubic CLE-AgNPs (λmax= 431 nm). CLE-AgNPs manifested noticeable antioxidant activity and prominent inhibitory effects on the tested bacteria. The minimum inhibitory concentration (MIC) of the CLE-AgNPs was 31.25 μg/mL for the eight bacterial species. Besides, the results revealed that CLE-AgNPs effectively suppressed the development of bacterial biofilms and could eradicate them. Conclusion: The present investigation introduced Cyclamen libanoticum as a novel bioresource into green chemistry to produce AgNPs with antibacterial and antioxidant capabilities.","PeriodicalId":10827,"journal":{"name":"Current Nanoscience","volume":"24 1","pages":""},"PeriodicalIF":1.5,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141587102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-10DOI: 10.2174/0115734137319139240614103935
Li Meng, Jidong Zhang, Cheng Chen, Shihao Dai, Qiong Li, Kun Xiang
Introduction: The development of cost-effective and efficient catalysts plays a pivotal role in the realization of hydrogen production through electrochemical water splitting. Method: In this study, two-dimensional NiCo2S4 nanosheets weresynthesized usinga hydrothermal method followed by a sulfidation process. Results: The resulting materials were thoroughly characterized to understand their morphology and structure. The findings indicate that the NiCo2S4 nanosheets exhibit exceptional electrical conductivity and a high density of pores, which facilitate electrolyte infiltration and interfacial charge transfer during electrochemical reactions. Furthermore, the incorporation of S2− modulates the electronic structure of metal ions, reducing the oxidation potential of metal sites and promoting the surface reconstruction of the electrode to form active species. Electrochemical tests conducted in a 1 M KOH solution using the synthesized catalyst as the working electrode demonstrate an overpotential of merely 280 mV and 300 mV at a current density of 20 mA cm−2 and 40 mA cm−2 , respectively, which are much lower than those of NiCo-LDH electrodes (360 mV and 410 mV). Conclusion: Furthermore, the NiCo2S4 electrode delivers a remarkably low Tafel slope of 47.9 mV dec−1 . This investigation presents a novel approach to the development of efficient transition metal-based electrocatalysts.
{"title":"Two-Dimensional NiCo2S4 Nanosheets Deliver Efficient Oxygen Evolution Reaction","authors":"Li Meng, Jidong Zhang, Cheng Chen, Shihao Dai, Qiong Li, Kun Xiang","doi":"10.2174/0115734137319139240614103935","DOIUrl":"https://doi.org/10.2174/0115734137319139240614103935","url":null,"abstract":"Introduction: The development of cost-effective and efficient catalysts plays a pivotal role in the realization of hydrogen production through electrochemical water splitting. Method: In this study, two-dimensional NiCo2S4 nanosheets weresynthesized usinga hydrothermal method followed by a sulfidation process. Results: The resulting materials were thoroughly characterized to understand their morphology and structure. The findings indicate that the NiCo2S4 nanosheets exhibit exceptional electrical conductivity and a high density of pores, which facilitate electrolyte infiltration and interfacial charge transfer during electrochemical reactions. Furthermore, the incorporation of S2− modulates the electronic structure of metal ions, reducing the oxidation potential of metal sites and promoting the surface reconstruction of the electrode to form active species. Electrochemical tests conducted in a 1 M KOH solution using the synthesized catalyst as the working electrode demonstrate an overpotential of merely 280 mV and 300 mV at a current density of 20 mA cm−2 and 40 mA cm−2 , respectively, which are much lower than those of NiCo-LDH electrodes (360 mV and 410 mV). Conclusion: Furthermore, the NiCo2S4 electrode delivers a remarkably low Tafel slope of 47.9 mV dec−1 . This investigation presents a novel approach to the development of efficient transition metal-based electrocatalysts.","PeriodicalId":10827,"journal":{"name":"Current Nanoscience","volume":"88 1","pages":""},"PeriodicalIF":1.5,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141587103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-10DOI: 10.2174/0115734137296780240529172003
Shaojun Wu, Xianglai Xu
: Carbon nanotube films are utilized in various fields, particularly electric heating, owing to their exceptional thermal and electrical properties. However, quantitative research on the electrothermal characteristics of carbon nanotube film is insufficient, and glass fiberreinforced epoxy-resin composites prepared through the electrothermal method of carbon nanotube films (i.e., the out-of-autoclave technique) have not yet been reported. Herein, according to a mathematical model and experimental demonstration, a quantitative relationship, T = T0 + (t/L2)·(V2σ)·(1/αw), was proposed to explain the electrothermal properties of carbon nanotube films. Glass fiber-reinforced composites with an outstanding tensile strength of 535.6 MPa and an elongation-at-break of 1.6% were prepared through the out-of-autoclave technique using the designed carbon nanotube film. The composites outperformed previous mechanical composites in terms of energy consumption. Experimental investigations and molecular simulations revealed the mechanical mechanisms of the composites. These findings quantitatively revealed the electrothermal properties of carbon nanotube films, advancing their application in the out-ofautoclave manufacturing of high-performance resin-matrix composites.
:碳纳米管薄膜因其优异的热学和电学特性被广泛应用于各个领域，尤其是电加热领域。然而，有关碳纳米管薄膜电热特性的定量研究尚不充分，通过碳纳米管薄膜电热法（即釜外技术）制备玻璃纤维增强环氧树脂复合材料的研究也尚未见报道。本文根据数学模型和实验证明，提出了一个定量关系 T = T0 + (t/L2)-(V2σ)-(1/αw) 来解释碳纳米管薄膜的电热特性。利用所设计的碳纳米管薄膜，通过釜外技术制备了玻璃纤维增强复合材料，其拉伸强度达到 535.6 兆帕，断裂伸长率为 1.6%。该复合材料在能耗方面优于以往的机械复合材料。实验研究和分子模拟揭示了复合材料的机械机理。这些发现定量揭示了碳纳米管薄膜的电热特性，推动了其在高压釜外制造高性能树脂基复合材料中的应用。
{"title":"Quantitative Study on the Electrothermal Properties of Carbon Nanotube Film and its Out-of-Autoclave-Manufactured Glass Fiber-Reinforced Epoxy-Resin Composites","authors":"Shaojun Wu, Xianglai Xu","doi":"10.2174/0115734137296780240529172003","DOIUrl":"https://doi.org/10.2174/0115734137296780240529172003","url":null,"abstract":": Carbon nanotube films are utilized in various fields, particularly electric heating, owing to their exceptional thermal and electrical properties. However, quantitative research on the electrothermal characteristics of carbon nanotube film is insufficient, and glass fiberreinforced epoxy-resin composites prepared through the electrothermal method of carbon nanotube films (i.e., the out-of-autoclave technique) have not yet been reported. Herein, according to a mathematical model and experimental demonstration, a quantitative relationship, T = T0 + (t/L2)·(V2σ)·(1/αw), was proposed to explain the electrothermal properties of carbon nanotube films. Glass fiber-reinforced composites with an outstanding tensile strength of 535.6 MPa and an elongation-at-break of 1.6% were prepared through the out-of-autoclave technique using the designed carbon nanotube film. The composites outperformed previous mechanical composites in terms of energy consumption. Experimental investigations and molecular simulations revealed the mechanical mechanisms of the composites. These findings quantitatively revealed the electrothermal properties of carbon nanotube films, advancing their application in the out-ofautoclave manufacturing of high-performance resin-matrix composites.","PeriodicalId":10827,"journal":{"name":"Current Nanoscience","volume":"26 1","pages":""},"PeriodicalIF":1.5,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141587104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Rice husk is an important agricultural waste that contains organic mass and bio-silica. Although some rice husks have been used as fuel, animal food, filler for wine fermentation, and fertilizer, the majority are discarded as agricultural waste, which does great harm to the environment. The conversion of rice husk to silicon carbide (SiC)-based materials satisfies the demand for the reutilization of solid wastes. Methods: The article reviews recent progress and patents on the SiC-based materials from rice husk. The possible development directions of the SiC-based materials from rice husks are also analyzed. Results: SiC materials with different morphologies, including microscale and nanoscale particles, nanoscale whiskers, and nanowires, can be prepared by high-temperature carbothermal reduction reaction from rice husk at the temperature of 1200-1800 °C, reaction time of 0.5-8 h, respectively. SiC-based composites, including SiC nanowires/C, Al/SiC, SiC/Si3N4, and SiC/Al2O3, can be obtained using rice husk as main source materials at 800-1800 °C. SiC-based materials exhibit great application potential in the fields of absorbents, optical devices, mechanical products, photocatalysts, semiconductors, and Li-ion batteries. Conclusion: The low cost of preparing SiC-based materials from rice husk, combining them with different compositions, and exploring new applications are important research directions in the future.
背景：稻壳是一种重要的农业废弃物，含有有机质和生物硅。虽然有些稻壳被用作燃料、动物食品、葡萄酒发酵的填充物和肥料，但大部分稻壳都作为农业废弃物被丢弃，对环境造成了极大的危害。将稻壳转化为碳化硅（SiC）基材料，满足了固体废弃物再利用的需求。方法：文章回顾了稻壳制碳化硅基材料的最新进展和专利。还分析了稻壳碳化硅基材料可能的发展方向。结果：在温度为 1200-1800 ℃、反应时间为 0.5-8 h 的条件下，利用稻壳的高温碳热还原反应可以制备出不同形貌的 SiC 材料，包括微米级和纳米级颗粒、纳米级晶须和纳米线。以稻壳为主要原料，在 800-1800 ℃下可制备出 SiC 基复合材料，包括 SiC 纳米线/C、Al/SiC、SiC/Si3N4 和 SiC/Al2O3。SiC 基材料在吸附剂、光学器件、机械产品、光催化剂、半导体和锂离子电池等领域具有巨大的应用潜力。结论从稻壳中低成本制备 SiC 基材料，并将其与不同成分相结合，探索新的应用领域，是未来的重要研究方向。
{"title":"Silicon Carbide-based Materials from Rice Husk","authors":"Qianmin Cong, Xingxing Zhu, Zhangjie Ban, Junzhe Li, Zhengyu Cai, Lizhai Pei","doi":"10.2174/0115734137316974240620095136","DOIUrl":"https://doi.org/10.2174/0115734137316974240620095136","url":null,"abstract":"Background: Rice husk is an important agricultural waste that contains organic mass and bio-silica. Although some rice husks have been used as fuel, animal food, filler for wine fermentation, and fertilizer, the majority are discarded as agricultural waste, which does great harm to the environment. The conversion of rice husk to silicon carbide (SiC)-based materials satisfies the demand for the reutilization of solid wastes. Methods: The article reviews recent progress and patents on the SiC-based materials from rice husk. The possible development directions of the SiC-based materials from rice husks are also analyzed. Results: SiC materials with different morphologies, including microscale and nanoscale particles, nanoscale whiskers, and nanowires, can be prepared by high-temperature carbothermal reduction reaction from rice husk at the temperature of 1200-1800 °C, reaction time of 0.5-8 h, respectively. SiC-based composites, including SiC nanowires/C, Al/SiC, SiC/Si3N4, and SiC/Al2O3, can be obtained using rice husk as main source materials at 800-1800 °C. SiC-based materials exhibit great application potential in the fields of absorbents, optical devices, mechanical products, photocatalysts, semiconductors, and Li-ion batteries. Conclusion: The low cost of preparing SiC-based materials from rice husk, combining them with different compositions, and exploring new applications are important research directions in the future.","PeriodicalId":10827,"journal":{"name":"Current Nanoscience","volume":"18 1","pages":""},"PeriodicalIF":1.5,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141587106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-31DOI: 10.2174/0115734137308989240520053704
Maryam Saadat, Sevda Jafari, Mohammad Mahmoudian, Muhammad Sarfraz, Farnaz Khaleseh, Parvin Zakeri-Milani, Javid Shahbazi-Mojarrad, Hadi Valizadeh
Aims:: The aim of this study was to synthesize two positively charged surfactants Stearoylcholine and Oleoylcholine from choline or vitamin B4, saturated and mono-unsaturated fatty acids to modify solid lipid nanoparticles (SLNs) in order to enhance cancer cell uptake. Methods:: These surfactants were synthesized by using the esterification method and then SLN formulations of unmodified and modified SLNs containing docetaxel were prepared by emulsification technique. Cytotoxicity of the SLNs was investigated in A549 and MCF7 cancer cells and their cell uptake was assessed by using fluorescent microscope and flow cytometry Results:: The results of our study revealed that SLNs pose a mean particle size range of 69-133 nm with spherical morphology. In vitro release study demonstrated a slow-release pattern for all three kinds of DTX-loaded SLNs. Stearoylcholine-containing SLNs showed the highest cytotoxic effect on both cells while cytotoxicity of Oleoylcholine SLNs exhibited a dose-dependent manner which may be due to the effect of saturated and mono-unsaturated parts of surfactants. According to flow cytometric analysis, OC and SC containing SLNs showed the highest uptake into A549 and MCF7 cells, respectively. Conclusion:: In conclusion, choline-based surfactants could effectively increase the A549 and MCF7 uptake of modified SLNs, which may be due to cationic surface, choline transporters, and special receptors and mediators.
{"title":"Choline Based Surfactants Promote Cellular Uptake of Solid Lipid Nanoparticles into Lung and Breast Cancer Cells","authors":"Maryam Saadat, Sevda Jafari, Mohammad Mahmoudian, Muhammad Sarfraz, Farnaz Khaleseh, Parvin Zakeri-Milani, Javid Shahbazi-Mojarrad, Hadi Valizadeh","doi":"10.2174/0115734137308989240520053704","DOIUrl":"https://doi.org/10.2174/0115734137308989240520053704","url":null,"abstract":"Aims:: The aim of this study was to synthesize two positively charged surfactants Stearoylcholine and Oleoylcholine from choline or vitamin B4, saturated and mono-unsaturated fatty acids to modify solid lipid nanoparticles (SLNs) in order to enhance cancer cell uptake. Methods:: These surfactants were synthesized by using the esterification method and then SLN formulations of unmodified and modified SLNs containing docetaxel were prepared by emulsification technique. Cytotoxicity of the SLNs was investigated in A549 and MCF7 cancer cells and their cell uptake was assessed by using fluorescent microscope and flow cytometry Results:: The results of our study revealed that SLNs pose a mean particle size range of 69-133 nm with spherical morphology. In vitro release study demonstrated a slow-release pattern for all three kinds of DTX-loaded SLNs. Stearoylcholine-containing SLNs showed the highest cytotoxic effect on both cells while cytotoxicity of Oleoylcholine SLNs exhibited a dose-dependent manner which may be due to the effect of saturated and mono-unsaturated parts of surfactants. According to flow cytometric analysis, OC and SC containing SLNs showed the highest uptake into A549 and MCF7 cells, respectively. Conclusion:: In conclusion, choline-based surfactants could effectively increase the A549 and MCF7 uptake of modified SLNs, which may be due to cationic surface, choline transporters, and special receptors and mediators.","PeriodicalId":10827,"journal":{"name":"Current Nanoscience","volume":"32 1","pages":""},"PeriodicalIF":1.5,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141198193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-27DOI: 10.2174/0115734137301010240507101533
Denise Yancey-Gray, Rogers Nyamwihura, Zikri Arslan, Ifedayo Victor Ogungbe
:: Nanoparticles derived from copper (Cu), zinc (Zn), and silver (Ag) have bactericidal activities, are biocompatible, and are malleable to different structural designs/shapes, making them attractive as antibacterial agents. The development of new antibacterial agents is particularly important because the emergence of multidrug-resistant (MDR) bacteria driven by overuse, misuse, and abuse of antibiotics has become a global problem. Drug resistance results in higher mortality and morbidity, increase in treatment cost, and longer hospital stays. Unfortunately, over the past three decades, the lack of adequate investments in developing new drugs to replace current and ineffective ones has compounded the problem. This review provides a comprehensive insight into the investigation of nanoparticles derived from Cu, Zn, and Ag as antibacterial agents, especially when combined with antibiotics. It provides mechanistic details about the activities of the nanoparticles and their limited structure-activity relationships. In addition, the effect of doping and its impact on the antibacterial activity of the nanomaterials is discussed, as well as the nanoparticles’ ability to inhibit or reduce bacterial growth on surfaces and prevent the development of antibiotic resistance by biofilms.
{"title":"Antibacterial Activities of Copper, Silver, and Zinc-Derived Nanoparticles and Their Capacity to Enhance the Antimicrobial Activities of Antibiotics","authors":"Denise Yancey-Gray, Rogers Nyamwihura, Zikri Arslan, Ifedayo Victor Ogungbe","doi":"10.2174/0115734137301010240507101533","DOIUrl":"https://doi.org/10.2174/0115734137301010240507101533","url":null,"abstract":":: Nanoparticles derived from copper (Cu), zinc (Zn), and silver (Ag) have bactericidal activities, are biocompatible, and are malleable to different structural designs/shapes, making them attractive as antibacterial agents. The development of new antibacterial agents is particularly important because the emergence of multidrug-resistant (MDR) bacteria driven by overuse, misuse, and abuse of antibiotics has become a global problem. Drug resistance results in higher mortality and morbidity, increase in treatment cost, and longer hospital stays. Unfortunately, over the past three decades, the lack of adequate investments in developing new drugs to replace current and ineffective ones has compounded the problem. This review provides a comprehensive insight into the investigation of nanoparticles derived from Cu, Zn, and Ag as antibacterial agents, especially when combined with antibiotics. It provides mechanistic details about the activities of the nanoparticles and their limited structure-activity relationships. In addition, the effect of doping and its impact on the antibacterial activity of the nanomaterials is discussed, as well as the nanoparticles’ ability to inhibit or reduce bacterial growth on surfaces and prevent the development of antibiotic resistance by biofilms.","PeriodicalId":10827,"journal":{"name":"Current Nanoscience","volume":"73 1","pages":""},"PeriodicalIF":1.5,"publicationDate":"2024-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141172079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background:: Carbon quantum dot synthesis, characterization, and applications have drawn a lot of attention lately. The most effective carbon precursors for creating carbon dots with intriguing chemical and physical characteristics are found in natural materials. Objectives:: In this study, we introduced a new approach using a carbon dot system that possesses both absorption and emission capabilities, allowing for the development of a fluorometric assay to detect Fe3+ metal ions. Method:: Hydrothermally, the Damask rose Carbon Quantum Dots (DRCQDs) were synthesized using Damask rose flower petals and various characterisations were performed, such as UV-Vis, FE-SEM, EDS, and Elemental mapping. The fluorescence intensity of CQDs varies depending on the particular metal ion present in the medium, and the blue fluorescence was selectively quenched. Results:: For the purpose of detecting Fe3+ ions at an excitation of 330 nm, CQDs were employed, which produced an extensive emission spectrum between 280 and 400 nm by varying the excitation wavelengths. More than other heavy metals, Fe3+ ions were observed to have a stronger fluorescence quenching effect for the CQDs. According to spectroscopic measurements, the generated carbon dots have a detection limit of 1.11 μM and could determine Fe3+ ions in the range of concentrations from 0–80 μM. Conclusion:: This new fluorescent carbon dot technology offers a promising method for the quick and effective identification of Fe3+ ions, particularly in real-world samples.
{"title":"Fluorometric Determination of Fe3+ Ions Using Green Synthesized Carbon Quantum Dots from Damask Rose flowers","authors":"Ridhu Varshini Murugan, Gokul Sridharan, Raji Atchudan, Sandeep Arya, Dhanraj Ganapathy, Ashok k. Sundramoorthy","doi":"10.2174/0115734137300899240509100717","DOIUrl":"https://doi.org/10.2174/0115734137300899240509100717","url":null,"abstract":"Background:: Carbon quantum dot synthesis, characterization, and applications have drawn a lot of attention lately. The most effective carbon precursors for creating carbon dots with intriguing chemical and physical characteristics are found in natural materials. Objectives:: In this study, we introduced a new approach using a carbon dot system that possesses both absorption and emission capabilities, allowing for the development of a fluorometric assay to detect Fe3+ metal ions. Method:: Hydrothermally, the Damask rose Carbon Quantum Dots (DRCQDs) were synthesized using Damask rose flower petals and various characterisations were performed, such as UV-Vis, FE-SEM, EDS, and Elemental mapping. The fluorescence intensity of CQDs varies depending on the particular metal ion present in the medium, and the blue fluorescence was selectively quenched. Results:: For the purpose of detecting Fe3+ ions at an excitation of 330 nm, CQDs were employed, which produced an extensive emission spectrum between 280 and 400 nm by varying the excitation wavelengths. More than other heavy metals, Fe3+ ions were observed to have a stronger fluorescence quenching effect for the CQDs. According to spectroscopic measurements, the generated carbon dots have a detection limit of 1.11 μM and could determine Fe3+ ions in the range of concentrations from 0–80 μM. Conclusion:: This new fluorescent carbon dot technology offers a promising method for the quick and effective identification of Fe3+ ions, particularly in real-world samples.","PeriodicalId":10827,"journal":{"name":"Current Nanoscience","volume":"98 1","pages":""},"PeriodicalIF":1.5,"publicationDate":"2024-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141172218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-27DOI: 10.2174/0115734137310581240513070742
Dilpreet Singh
: This mini-review article focuses on the recent advancements in nano-biosensors for the detection of epigenetic changes, a burgeoning field at the intersection of nanotechnology and cancer diagnostics. Epigenetic modifications, including DNA methylation, histone modification, and non-coding RNA expression, play a crucial role in cancer progression and drug resistance. The advent of nano-biosensors has introduced highly sensitive and specific methods for detecting these changes, surpassing the capabilities of traditional diagnostic tools. This article delves into various nano-biosensors, such as gold nanoparticles, quantum dots, carbon nanotubes, and graphene oxide sensors, highlighting their unique properties and applications in detecting epigenetic markers. It emphasizes the significance of early and accurate detection of epigenetic alterations in cancer, which opens new pathways for early diagnosis, monitoring treatment efficacy, and developing personalized therapeutic strategies. The review also addresses the technical challenges and limitations of current nano-biosensor technologies, including issues related to sensitivity, specificity, and biocompatibility. Furthermore, it explores the ethical and safety considerations in the clinical application of these nanotechnologies. The discussion extends to the potential future developments in this field, emphasizing interdisciplinary research and the integration of artificial intelligence for data analysis. This comprehensive overview of nano-biosensors for epigenetic change detection underscores their transformative potential in cancer research, offering insights into their current state, challenges, and future prospects in advancing personalized cancer care.
:这篇微型综述文章重点介绍了用于检测表观遗传变化的纳米生物传感器的最新进展，这是纳米技术和癌症诊断学交叉领域的一个新兴领域。表观遗传修饰（包括 DNA 甲基化、组蛋白修饰和非编码 RNA 表达）在癌症进展和耐药性方面发挥着至关重要的作用。纳米生物传感器的出现为检测这些变化提供了高灵敏度和特异性的方法，超越了传统诊断工具的能力。本文深入探讨了各种纳米生物传感器，如金纳米粒子、量子点、碳纳米管和氧化石墨烯传感器，重点介绍了它们在检测表观遗传标记方面的独特性能和应用。报告强调了早期准确检测癌症表观遗传学改变的重要意义，这为早期诊断、监测疗效和开发个性化治疗策略开辟了新途径。该综述还探讨了当前纳米生物传感器技术面临的技术挑战和局限性，包括与灵敏度、特异性和生物相容性有关的问题。此外，它还探讨了这些纳米技术临床应用中的伦理和安全问题。讨论延伸到这一领域未来的潜在发展，强调跨学科研究和数据分析中的人工智能整合。这篇关于用于表观遗传变化检测的纳米生物传感器的综述强调了它们在癌症研究中的变革潜力，并深入探讨了它们在推进个性化癌症治疗方面的现状、挑战和未来前景。
{"title":"A Short Appraisal on Nano-biosensors for Epigenetic Changes Detection: A Transformative Innovation","authors":"Dilpreet Singh","doi":"10.2174/0115734137310581240513070742","DOIUrl":"https://doi.org/10.2174/0115734137310581240513070742","url":null,"abstract":": This mini-review article focuses on the recent advancements in nano-biosensors for the detection of epigenetic changes, a burgeoning field at the intersection of nanotechnology and cancer diagnostics. Epigenetic modifications, including DNA methylation, histone modification, and non-coding RNA expression, play a crucial role in cancer progression and drug resistance. The advent of nano-biosensors has introduced highly sensitive and specific methods for detecting these changes, surpassing the capabilities of traditional diagnostic tools. This article delves into various nano-biosensors, such as gold nanoparticles, quantum dots, carbon nanotubes, and graphene oxide sensors, highlighting their unique properties and applications in detecting epigenetic markers. It emphasizes the significance of early and accurate detection of epigenetic alterations in cancer, which opens new pathways for early diagnosis, monitoring treatment efficacy, and developing personalized therapeutic strategies. The review also addresses the technical challenges and limitations of current nano-biosensor technologies, including issues related to sensitivity, specificity, and biocompatibility. Furthermore, it explores the ethical and safety considerations in the clinical application of these nanotechnologies. The discussion extends to the potential future developments in this field, emphasizing interdisciplinary research and the integration of artificial intelligence for data analysis. This comprehensive overview of nano-biosensors for epigenetic change detection underscores their transformative potential in cancer research, offering insights into their current state, challenges, and future prospects in advancing personalized cancer care.","PeriodicalId":10827,"journal":{"name":"Current Nanoscience","volume":"70 1","pages":""},"PeriodicalIF":1.5,"publicationDate":"2024-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141172221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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