Pub Date : 2022-07-21DOI: 10.37290/ctnr2641-452x.20:666-668
Chun-Hsien Yu, Ya-Hsuan Lin, Ching-Feng Cheng, C. Kuo
Fibrosis in the liver can result in portal hypertension and structural changes, eventually progressing to cirrhosis or hepatocellular carcinoma. Liver fibrosis is caused by the activation of liver hepatic stellate cells. Treatment of liver fibrosis may involve the induction of apoptosis or prevention of activation of activated hepatic stellate cells. A novel therapeutic strategy for treating liver fibrosis caused by hepatic stellate cells may be developed through complementary and alternative therapies. Therefore, in this article, we discuss recent investigations into the complementary and alternative medicine as a means of preventing and treating liver fibrosis.
{"title":"Complementary and Alternative Medicine for Liver Diseases","authors":"Chun-Hsien Yu, Ya-Hsuan Lin, Ching-Feng Cheng, C. Kuo","doi":"10.37290/ctnr2641-452x.20:666-668","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.20:666-668","url":null,"abstract":"Fibrosis in the liver can result in portal hypertension and structural changes, eventually progressing to cirrhosis or hepatocellular carcinoma. Liver fibrosis is caused by the activation of liver hepatic stellate cells. Treatment of liver fibrosis may involve the induction of apoptosis or prevention of activation of activated hepatic stellate cells. A novel therapeutic strategy for treating liver fibrosis caused by hepatic stellate cells may be developed through complementary and alternative therapies. Therefore, in this article, we discuss recent investigations into the complementary and alternative medicine as a means of preventing and treating liver fibrosis.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47991004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-15DOI: 10.37290/ctnr2641-452x.20:705-709
Yu Dong, Xiaoran Shen, Yifeng Zhang
To evaluate the efficacy of probiotics combined with quadruple therapy in treating Helicobacter pylori infection, 240 elderly H. pylori-infected patients were recruited and divided equally into control and treatment groups. The control group received quadruple therapy (rabeprazole sodium + colloidal bismuth pectin dry suspension + amoxicillin + clarithromycin), and the treatment group was given additional bifid-triple viable (probiotics composed of Enterococcus, Lactobacillus acidophilus, and Bifidobacterium) capsules orally. The gastric function, inflammatory cytokine levels, gastric mucosa histopathological change scores, clinical symptom scores, clinical efficacy, and adverse reactions were compared between the two groups. Total curative effect rate was higher in the treatment group than the control group. The symptom scores of acid reflux and belching, nausea and vomiting, and epigastric pain were also lower in the treatment group than the control group. Also, the incidence of adverse reactions was lower in the treatment group (20.00%) than the control group (36.67%). Furthermore, the treatment group had higher decrease in gastric mucosa histopathological change scores, gastrin and motilin levels, and interleukin-8, and tumor necrosis factor levels than the control group. In conclusion, probiotics combined with quadruple therapy can suppress release of serum inflammatory cytokines, facilitate digestive function improvement and mucosal healing, elevate H. pylori eradication rate, and reduce therapy-related adverse reactions in H. pylori-infected patients.
{"title":"Efficacy Evaluation of Probiotics Combined with Quadruple Therapy in Treating Helicobacter pylori Infection","authors":"Yu Dong, Xiaoran Shen, Yifeng Zhang","doi":"10.37290/ctnr2641-452x.20:705-709","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.20:705-709","url":null,"abstract":"To evaluate the efficacy of probiotics combined with quadruple therapy in treating Helicobacter pylori infection, 240 elderly H. pylori-infected patients were recruited and divided equally into control and treatment groups. The control group received quadruple therapy (rabeprazole sodium + colloidal bismuth pectin dry suspension + amoxicillin + clarithromycin), and the treatment group was given additional bifid-triple viable (probiotics composed of Enterococcus, Lactobacillus acidophilus, and Bifidobacterium) capsules orally. The gastric function, inflammatory cytokine levels, gastric mucosa histopathological change scores, clinical symptom scores, clinical efficacy, and adverse reactions were compared between the two groups. Total curative effect rate was higher in the treatment group than the control group. The symptom scores of acid reflux and belching, nausea and vomiting, and epigastric pain were also lower in the treatment group than the control group. Also, the incidence of adverse reactions was lower in the treatment group (20.00%) than the control group (36.67%). Furthermore, the treatment group had higher decrease in gastric mucosa histopathological change scores, gastrin and motilin levels, and interleukin-8, and tumor necrosis factor levels than the control group. In conclusion, probiotics combined with quadruple therapy can suppress release of serum inflammatory cytokines, facilitate digestive function improvement and mucosal healing, elevate H. pylori eradication rate, and reduce therapy-related adverse reactions in H. pylori-infected patients.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44148205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-06DOI: 10.37290/ctnr2641-452x.20:698-704
Xian Guan, Shanmai Guo
Uremia is associated with kidney injury and contributes to chronic renal failure. Ligustrazine, a bioactive alkaloid from traditional Chinese herb Ligusticum wallichii Franchat, exerts renal-protective effect against acute kidney injury. The role of ligustrazine in uremia-associated kidney injury was investigated. To induce uremia, rats were subjected to 5/6 nephrectomy and intravenously administered with saline. Survival rate of rats was decreased by 5/6 nephrectomy, and levels of blood urea nitrogen, serum creatinine, and 24 h urine protein were elevated. Daily administration of ligustrazine to these rats increased the survival rate and reduced levels of blood urea nitrogen, serum creatinine, and 24 h urine protein output. Moreover, analysis of kidney histology showed that ligustrazine also ameliorated pathological changes in kidney. Finally, ligustrazine reduced levels of proinflammatory cytokines and suppressed renal apoptosis in the kidney tissues of uremic rats. In addition, ligustrazine downregulated protein expression of Wnt1 and β-catenin and inhibited nuclear distribution of β-catenin in uremic rats. In conclusion, ligustrazine protects rats against uremia-associated kidney injury and renal inflammation through inactivation of Wnt1/β-catenin pathway.
{"title":"Ligustrazine Alleviates Kidney Injury in a Rat Model of Uremia via Attenuation of Wnt/β-Catenin Signaling Pathway","authors":"Xian Guan, Shanmai Guo","doi":"10.37290/ctnr2641-452x.20:698-704","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.20:698-704","url":null,"abstract":"Uremia is associated with kidney injury and contributes to chronic renal failure. Ligustrazine, a bioactive alkaloid from traditional Chinese herb Ligusticum wallichii Franchat, exerts renal-protective effect against acute kidney injury. The role of ligustrazine in uremia-associated kidney injury was investigated. To induce uremia, rats were subjected to 5/6 nephrectomy and intravenously administered with saline. Survival rate of rats was decreased by 5/6 nephrectomy, and levels of blood urea nitrogen, serum creatinine, and 24 h urine protein were elevated. Daily administration of ligustrazine to these rats increased the survival rate and reduced levels of blood urea nitrogen, serum creatinine, and 24 h urine protein output. Moreover, analysis of kidney histology showed that ligustrazine also ameliorated pathological changes in kidney. Finally, ligustrazine reduced levels of proinflammatory cytokines and suppressed renal apoptosis in the kidney tissues of uremic rats. In addition, ligustrazine downregulated protein expression of Wnt1 and β-catenin and inhibited nuclear distribution of β-catenin in uremic rats. In conclusion, ligustrazine protects rats against uremia-associated kidney injury and renal inflammation through inactivation of Wnt1/β-catenin pathway.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47174129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-06DOI: 10.37290/ctnr2641-452x.21:40-46
Juan Wang, Jianyong Zhang, Yan Zhao
Calycosin is an isoflavone isolated from the roots of Astragalus membranaceus. Due to its antioxidant and anti-inflammatory activities, it has been extensively used in traditional Chinese medicine formulations. Herein, we have evaluated the mechanism of action of calycosin using high glucose induced HRCEC cells as a model. The observed effects of calycosin include alleviation of oxidative stress induced by high glucose through promotion of SOD, GSH-Px and inhibition of ROS expression. Moreover, calycosin relieved HG-induced inflammation and pyroptosis by upregulating IL-1β, IL-18 and downregulating NLRP3, ASC, and cleaving caspase-1/procaspase-1. Calycosin also inhibited HMGB1/NF-κB pathway activation by promoting p-P65/P65, p-IκBα, HMGB1 and decreasing IκBα. All of these results support the notion that calycosin alleviates oxidative stress and pyroptosis of HRCEC cells induced by high glucose by inhibiting activation of the HMGB1/NF-κB pathway.
{"title":"Calycosin Alleviates Oxidative Stress and Pyroptosis Induced by High Glucose in Human Retinal Capillary Endothelial Cells Induced by High Glucose","authors":"Juan Wang, Jianyong Zhang, Yan Zhao","doi":"10.37290/ctnr2641-452x.21:40-46","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:40-46","url":null,"abstract":"Calycosin is an isoflavone isolated from the roots of Astragalus membranaceus. Due to its antioxidant and anti-inflammatory activities, it has been extensively used in traditional Chinese medicine formulations. Herein, we have evaluated the mechanism of action of calycosin using high glucose induced HRCEC cells as a model. The observed effects of calycosin include alleviation of oxidative stress induced by high glucose through promotion of SOD, GSH-Px and inhibition of ROS expression. Moreover, calycosin relieved HG-induced inflammation and pyroptosis by upregulating IL-1β, IL-18 and downregulating NLRP3, ASC, and cleaving caspase-1/procaspase-1. Calycosin also inhibited HMGB1/NF-κB pathway activation by promoting p-P65/P65, p-IκBα, HMGB1 and decreasing IκBα. All of these results support the notion that calycosin alleviates oxidative stress and pyroptosis of HRCEC cells induced by high glucose by inhibiting activation of the HMGB1/NF-κB pathway.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44221844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-04DOI: 10.37290/ctnr2641-452x.20:669-674
Lianyou Wang, Cuixia Yang, Nanning Lv, Lantao Zhao, Liang Wang
We have evaluated the effect of Feiji recipe on efficacy of docetaxel plus cisplatin treatment on the quality of life of the elderly with lung cancer. To this end, 186 lung cancer patients receiving treatment at the Second People’s Hospital of Lianyungang, Lianyungang City, Jiangsu Province were recruited between January 2017 and December 2021 and randomly divided into control (receiving docetaxel + cisplatin) and treatment (receiving docetaxel + cisplatin + Feiji recipe) groups of 93 patients. Both groups received hydration on the day of cisplatin use and received preventive treatment for emesis, liver protection, acid suppression, and mucosal protection. Post-treatment depletion of cluster of differentiation 3 protein, cluster of differentiation 4 protein, and cluster of differentiation 4 protein/cluster of differentiation 8 protein levels in the treatment group were significantly (P < 0.05) ameliorated/enhanced compared to the control group. Cluster of differentiation 3 protein and cluster of differentiation 4 protein/cluster of differentiation 8 protein levels in the treatment group were upregulated relative to controls (P < 0.05), whereas cytokeratin 19 fragment antigen, cancer antigen 125, and carcinoembryonic antigen levels in the treatment group were depleted relative to controls after treatment (P < 0.05). However, there was no significant difference in natural killer cell counts in the two groups before and after treatment (P > 0.05). The overall treatment effectiveness (74.18% and 90.32%) and the progressive disease rates (25.82% and 9.68%) in the control and treatment groups, respectively (P < 0.05). The physical/emotional/cognitive/role function scores in the treatment group were markedly increased compared to the control group (P < 0.05). In conclusion, Feiji recipe markedly enhanced efficacy of all measures of treating lung cancer by docetaxel + cisplatin.
{"title":"Feiji Recipe Elevates the Quality of Life of the Elderly with Lung Cancer on Docetaxel Plus Cisplatin Chemotherapy","authors":"Lianyou Wang, Cuixia Yang, Nanning Lv, Lantao Zhao, Liang Wang","doi":"10.37290/ctnr2641-452x.20:669-674","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.20:669-674","url":null,"abstract":"We have evaluated the effect of Feiji recipe on efficacy of docetaxel plus cisplatin treatment on the quality of life of the elderly with lung cancer. To this end, 186 lung cancer patients receiving treatment at the Second People’s Hospital of Lianyungang, Lianyungang City, Jiangsu Province were recruited between January 2017 and December 2021 and randomly divided into control (receiving docetaxel + cisplatin) and treatment (receiving docetaxel + cisplatin + Feiji recipe) groups of 93 patients. Both groups received hydration on the day of cisplatin use and received preventive treatment for emesis, liver protection, acid suppression, and mucosal protection. Post-treatment depletion of cluster of differentiation 3 protein, cluster of differentiation 4 protein, and cluster of differentiation 4 protein/cluster of differentiation 8 protein levels in the treatment group were significantly (P < 0.05) ameliorated/enhanced compared to the control group. Cluster of differentiation 3 protein and cluster of differentiation 4 protein/cluster of differentiation 8 protein levels in the treatment group were upregulated relative to controls (P < 0.05), whereas cytokeratin 19 fragment antigen, cancer antigen 125, and carcinoembryonic antigen levels in the treatment group were depleted relative to controls after treatment (P < 0.05). However, there was no significant difference in natural killer cell counts in the two groups before and after treatment (P > 0.05). The overall treatment effectiveness (74.18% and 90.32%) and the progressive disease rates (25.82% and 9.68%) in the control and treatment groups, respectively (P < 0.05). The physical/emotional/cognitive/role function scores in the treatment group were markedly increased compared to the control group (P < 0.05). In conclusion, Feiji recipe markedly enhanced efficacy of all measures of treating lung cancer by docetaxel + cisplatin.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42637315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-06-23DOI: 10.37290/ctnr2641-452x.20:685-690
R. Mallaci Bocchio, M. Lo Monaco, G. Natoli, S. Scibetta, S. Corrao
Despite their gastrointestinal side effects, oral iron supplements are the first-line therapy in iron deficiency anemia. This study aims to compare different iron formulations in anemic outpatients. One-hundred and six outpatients with sideropenic microcytic hypochromic anemia (Hb < 12 g/dL for women, Hb < 13 g/dL for men) were enrolled and divided into two groups (Hb > 10 g/dL and Hb < 10 g/dL). One group was randomized (1:1) to receive sucrosomal ferric pyrophosphate or micronized microencapsulated ferric pyrophosphate, while the other group was randomized (1:1:1) to receive sucrosomal ferric pyrophosphate, micronized microencapsulated ferric pyrophosphate or intravenous ferric gluconate. After 3 months of follow-up, hemoglobin was significantly higher in the micronized microencapsulated ferric pyrophosphate group than in the sucrosomal ferric pyrophosphate group (1.87 vs 1.10; P = 0.04). No significant difference in adverse events was registered between the two groups. In patients with Hb > 10 g/dL, the pyrophosphate or micronized microencapsulated ferric pyrophosphate (30 mg/day) treatment in combination with folic acid (400 mcg), lactoferrin (10 mg), and vitamin C (180 mg) we found out to bring in a significant increase in hemoglobin, without any significant side effects. The reason for this effectiveness is probably due to its favorable bioavailability. Further comparative studies are needed with other forms of iron.
{"title":"A Randomized Controlled Pilot Study to Compare the Efficacy of Different Iron Formulations: Sucrosomal Ferric Pyrophosphate, Micronized Microencapsulated Ferric Pyrophosphate, and Intravenous Ferric Gluconate","authors":"R. Mallaci Bocchio, M. Lo Monaco, G. Natoli, S. Scibetta, S. Corrao","doi":"10.37290/ctnr2641-452x.20:685-690","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.20:685-690","url":null,"abstract":"Despite their gastrointestinal side effects, oral iron supplements are the first-line therapy in iron deficiency anemia. This study aims to compare different iron formulations in anemic outpatients. One-hundred and six outpatients with sideropenic microcytic hypochromic anemia (Hb < 12 g/dL for women, Hb < 13 g/dL for men) were enrolled and divided into two groups (Hb > 10 g/dL and Hb < 10 g/dL). One group was randomized (1:1) to receive sucrosomal ferric pyrophosphate or micronized microencapsulated ferric pyrophosphate, while the other group was randomized (1:1:1) to receive sucrosomal ferric pyrophosphate, micronized microencapsulated ferric pyrophosphate or intravenous ferric gluconate. After 3 months of follow-up, hemoglobin was significantly higher in the micronized microencapsulated ferric pyrophosphate group than in the sucrosomal ferric pyrophosphate group (1.87 vs 1.10; P = 0.04). No significant difference in adverse events was registered between the two groups. In patients with Hb > 10 g/dL, the pyrophosphate or micronized microencapsulated ferric pyrophosphate (30 mg/day) treatment in combination with folic acid (400 mcg), lactoferrin (10 mg), and vitamin C (180 mg) we found out to bring in a significant increase in hemoglobin, without any significant side effects. The reason for this effectiveness is probably due to its favorable bioavailability. Further comparative studies are needed with other forms of iron.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42454880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-18DOI: 10.37290/ctnr2641-452x.20m:m24-m29
Sehad Al-Arifi, M. Alharbi
An online semistructured survey assessing probiotics knowledge and perception of health care providers in Saudi Arabia was conducted in Riyadh city between March and December 2020. A total of 333 participants were randomly sampled from King Khaled University Hospital and the Saudi Health Commission database. The mean, standard deviation, frequency, and percentages were used to present the demographic features of the participating professionals. Analysis of variance and Tukey multiple comparison tests were used to evaluate probiotic knowledge considering the demography of more than two subcategories. From the initial group, 95.7% of health professionals participated in this study. The group was made up of 52.3% female, aged 30–44 (62.8%), mostly nurses (46.8%). A total of 85.3% of participants were familiar with the term “probiotic” and 64% considered probiotics safe for general health; beneficial to gut health and irritable bowel syndrome (42.6% and 32.4%, respectively). However, only 25.5% and 24.6% of participants thought probiotics could moderately benefit ulcerative colitis and Crohn’s disease, respectively. A great majority of participants have no concerns about probiotics use (77.5%), and only minor concerns about safety (22.5%). This research concluded that health professionals were better aware of probiotic knowledge despite their limited understanding of the probiotics used for inflammatory bowel disease. In Saudi Arabia, building new guidelines for probiotics, their types, and their uses in the health sector is needed.
{"title":"Knowledge and Perception of Health Care Providers About Probiotics in Saudi Arabia","authors":"Sehad Al-Arifi, M. Alharbi","doi":"10.37290/ctnr2641-452x.20m:m24-m29","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.20m:m24-m29","url":null,"abstract":"An online semistructured survey assessing probiotics knowledge and perception of health care providers in Saudi Arabia was conducted in Riyadh city between March and December 2020. A total of 333 participants were randomly sampled from King Khaled University Hospital and the Saudi Health Commission database. The mean, standard deviation, frequency, and percentages were used to present the demographic features of the participating professionals. Analysis of variance and Tukey multiple comparison tests were used to evaluate probiotic knowledge considering the demography of more than two subcategories. From the initial group, 95.7% of health professionals participated in this study. The group was made up of 52.3% female, aged 30–44 (62.8%), mostly nurses (46.8%). A total of 85.3% of participants were familiar with the term “probiotic” and 64% considered probiotics safe for general health; beneficial to gut health and irritable bowel syndrome (42.6% and 32.4%, respectively). However, only 25.5% and 24.6% of participants thought probiotics could moderately benefit ulcerative colitis and Crohn’s disease, respectively. A great majority of participants have no concerns about probiotics use (77.5%), and only minor concerns about safety (22.5%). This research concluded that health professionals were better aware of probiotic knowledge despite their limited understanding of the probiotics used for inflammatory bowel disease. In Saudi Arabia, building new guidelines for probiotics, their types, and their uses in the health sector is needed.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41856813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-05-04DOI: 10.37290/ctnr2641-452x.20m:m30-m37
H. Althubaiti
The relationship between snack preferences/healthiness and health parameters is still poorly defined. Most children choose snacks low in nutritional value, which may contribute to the rise in childhood obesity. This study has examined children’s snack preferences and healthiness by age and gender and correlated them with their health parameters. Scottish Nursery and Primary children aged 3–12 years (n = 472) performed snack card sorting exercises in which they were presented with 18 different colored snack images, which counted as one portion, followed by two main snack questions related to snack healthiness and preferences. Health parameters were measured. Older children were better able to determine which snacks were healthier based on their energy content. Children with a higher body mass index percentile were not found to have a specific preference for unhealthy snacks based on the four nutritional components. However, snacks high in fat and sugar (and low in energy and salt) were preferred by children with higher body fat. A positive relationship was observed between the energy content of the children’s top five snacks selected for healthiness and their weight, waist circumference, hip circumference, waist-to-hip ratio, and waist-to-height ratio. There was only a negative relationship with height and body fat. The relationship between children’s perceptions of snack preferences and healthiness and their health parameters is still unclear and needs further investigation.
{"title":"The Perception of Snack Healthiness and Preferences in Children is Related to Health Parameter Measures","authors":"H. Althubaiti","doi":"10.37290/ctnr2641-452x.20m:m30-m37","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.20m:m30-m37","url":null,"abstract":"The relationship between snack preferences/healthiness and health parameters is still poorly defined. Most children choose snacks low in nutritional value, which may contribute to the rise in childhood obesity. This study has examined children’s snack preferences and healthiness by age and gender and correlated them with their health parameters. Scottish Nursery and Primary children aged 3–12 years (n = 472) performed snack card sorting exercises in which they were presented with 18 different colored snack images, which counted as one portion, followed by two main snack questions related to snack healthiness and preferences. Health parameters were measured. Older children were better able to determine which snacks were healthier based on their energy content. Children with a higher body mass index percentile were not found to have a specific preference for unhealthy snacks based on the four nutritional components. However, snacks high in fat and sugar (and low in energy and salt) were preferred by children with higher body fat. A positive relationship was observed between the energy content of the children’s top five snacks selected for healthiness and their weight, waist circumference, hip circumference, waist-to-hip ratio, and waist-to-height ratio. There was only a negative relationship with height and body fat. The relationship between children’s perceptions of snack preferences and healthiness and their health parameters is still unclear and needs further investigation.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47255456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-26DOI: 10.37290/ctnr2641-452x.20:603-609
F. Zhou, Binxin Cai, Shaojiang Ruan, L. He, Weiqing Huang, Qi Wei
Acute saline stress can cause death of Phasolosma esculenta, an important aquaculture species in China. Hence, investigating the sensitivity and physiological responses of P. esculenta to saline stress is important. The molecular, physiological, and immune responses of the intestine and body wall of P. esculenta upon saline stress were investigated in this study. The mortality rate of P. esculenta increased with the decreasing salinity. The Na+/K+-ATPase and acid phosphatase activity peaked at 6 h and 12 h, respectively, in the intestine and body wall, and subsequently stabilized at a higher level than control group. Further, superoxide dismutase activity significantly decreased within 12 h and then increased slowly, while its genes expression decreased and reached its lowest level at 6 h. In the intestine and body wall of P. esculenta, saline stress induced the transcription of Heat Shock Protein-70, Heat Shock Protein-90, and ferritin, along with the enlargement and loosening of connective tissue cells. Moreover, saline stress induced a more prominent adaptive response in the intestine than body wall. This research indicated that the enzymatic system, nonenzymatic system, and gene expressions of P. esculenta changed under low saline stress and provided references for the further research on the low saline stress response in P. esculenta.
{"title":"Effects of Low Salinity on the Physiological Indices, Stress-Related Gene Expression, and Histological Changes in Phasolosma Esculenta","authors":"F. Zhou, Binxin Cai, Shaojiang Ruan, L. He, Weiqing Huang, Qi Wei","doi":"10.37290/ctnr2641-452x.20:603-609","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.20:603-609","url":null,"abstract":"Acute saline stress can cause death of Phasolosma esculenta, an important aquaculture species in China. Hence, investigating the sensitivity and physiological responses of P. esculenta to saline stress is important. The molecular, physiological, and immune responses of the intestine and body wall of P. esculenta upon saline stress were investigated in this study. The mortality rate of P. esculenta increased with the decreasing salinity. The Na+/K+-ATPase and acid phosphatase activity peaked at 6 h and 12 h, respectively, in the intestine and body wall, and subsequently stabilized at a higher level than control group. Further, superoxide dismutase activity significantly decreased within 12 h and then increased slowly, while its genes expression decreased and reached its lowest level at 6 h. In the intestine and body wall of P. esculenta, saline stress induced the transcription of Heat Shock Protein-70, Heat Shock Protein-90, and ferritin, along with the enlargement and loosening of connective tissue cells. Moreover, saline stress induced a more prominent adaptive response in the intestine than body wall. This research indicated that the enzymatic system, nonenzymatic system, and gene expressions of P. esculenta changed under low saline stress and provided references for the further research on the low saline stress response in P. esculenta.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45266387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-04-26DOI: 10.37290/ctnr2641-452x.20:635-640
H. Du, Shidong Duan, Rui Lei, Xiao-Yu Liu
Insulin resistance is an element of metabolic syndrome, manifested as a decrease in glucose uptake, which often leads to a variety of complications, including type 2 diabetes. Astragalin is a natural flavonoid, isolated from traditional medicinal plants, such as Cuscuta chinensis, that has been shown to exhibit a variety of pharmacological activities with anti-inflammatory, antioxidant, neuroprotective, cardioprotective, antiobesity, antiosteoporotic, anticancer, antiulcer, and antidiabetic properties. However, the mechanism of astragalin on insulin resistance has not yet been elucidated. To this end, we examined the effect of astragalin on palmitic acid-induced insulin resistance in HepG2 cells. The effects of the co-incubation of PA and astragalin on the cell viability, superoxide dismutase, fat content, and markers of oxidative stress in HepG2 cells were measured. The results show that astragalin restored the cell viability, reduced oxidative stress, and insulin resistance in palmitic acid treated HepG2 cells. The protective effect of astragalin on palmitic acid-induced lipotoxicity in HepG2 cells was through inhibition of NF-was through inhibition of NF-κ and JNK signaling pathways.
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