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Effects of Garlicin on Proliferation and Differentiation of HL-60 Cells 大蒜素对HL-60细胞增殖和分化的影响
IF 0.5 4区 医学 Q4 Medicine Pub Date : 2023-04-07 DOI: 10.37290/ctnr2641-452x.21:109-116
Jinshen Wang, Chun-qing Bu, Yanyan Wang, Haiyan Ye, Yue Han, Daogang Qin
We have explored the effect of garlicin, a biologically active compound isolated from garlic, on the proliferation and differentiation of HL-60 leukemia cells. To this end, we measured the effect of garlicin on cell proliferation, cell morphology, cell cycle, and the expression cluster of differentiation molecules 11b and 15, B-cell lymphoma 2 protein, and BCL2-associated X proteins. All-trans retinoic acid and arsenic trioxide treatments served as positive controls for comparison. Results show that garlicin significantly inhibited the proliferation of HL-60 cells and blocked most cells in the G0/G1 phase, with an effect stronger than all-trans retinoic acid or arsenic trioxide treatments. The ability to induce cell maturation and differentiation was like that of all-trans retinoic acid, which may play a role by downregulating the expression of B-cell lymphoma 2 protein and upregulating the expression of BCL2-associated X protein. In conclusion, garlicin significantly inhibits the proliferation and induces differentiation of HL-60 cells, and thus it may become a new clinically viable differentiation-inducing agent.
我们研究了大蒜素对HL-60白血病细胞增殖和分化的影响。为此,我们测量了大蒜素对细胞增殖、细胞形态、细胞周期以及分化分子11b和15、b细胞淋巴瘤2蛋白和bcl2相关X蛋白表达簇的影响。全反式维甲酸和三氧化二砷处理作为阳性对照进行比较。结果表明,大蒜素显著抑制HL-60细胞的增殖,并在G0/G1期阻断大部分细胞,其作用强于全反式维甲酸和三氧化二砷处理。其诱导细胞成熟和分化的能力与全反式维甲酸相似,可能通过下调b细胞淋巴瘤2蛋白的表达和上调bcl2相关X蛋白的表达来发挥作用。综上所述,大蒜素能显著抑制HL-60细胞的增殖并诱导其分化,可能成为一种新的临床可行的分化诱导剂。
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引用次数: 0
The Effect of Gum Arabic on Cholesterol Synthesis and Serum Lipids in Atherogenic Rats 阿拉伯胶对动脉粥样硬化大鼠胆固醇合成和血脂的影响
IF 0.5 4区 医学 Q4 Medicine Pub Date : 2023-04-07 DOI: 10.37290/ctnr2641-452x.21:163-168
Abuelgassim Omer Abuelgassim, Abeer Al-Otaibi, Seema Zargar
In the current study, we have evaluated the effect of gum Arabic on cholesterol homeostasis in atherogenic rats. To this end, adult male Wistar rats were treated orally with increasing concentrations of gum Arabic for 6 consecutive weeks, and serum concentrations of markers of cholesterol homeostasis (total cholesterol, low-density lipoprotein, and 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase activity) were evaluated. Treatment of atherogenic rats with gum Arabic improved serum levels of markers of cholesterol homeostasis. Also, gum Arabic did not reveal any harmful effect on the liver tissue of normal control rats, whereas the liver tissue of atherogenic-treated rats showed improvements in healing, inflammation, and necrosis. In conclusion, gum Arabic may serve to improve cholesterol homeostasis in patients with hypercholesterolemia.
在目前的研究中,我们评估了阿拉伯树胶对致动脉粥样硬化大鼠胆固醇稳态的影响。为此,成年雄性Wistar大鼠连续6周口服浓度增加的阿拉伯树胶,并评估胆固醇稳态标志物(总胆固醇、低密度脂蛋白和3-羟基-3-甲基戊二酰辅酶A还原酶活性)的血清浓度。用阿拉伯树胶治疗致动脉粥样硬化大鼠可提高胆固醇稳态标志物的血清水平。此外,阿拉伯树胶对正常对照大鼠的肝组织没有任何有害影响,而动脉粥样硬化治疗大鼠的肝脏组织在愈合、炎症和坏死方面有所改善。总之,阿拉伯树胶可能有助于改善高胆固醇血症患者的胆固醇稳态。
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引用次数: 0
Prevalence and Determinants of Dietary Supplements Use Among Saudi Infants and Toddlers 沙特婴幼儿膳食补充剂使用的患病率和决定因素
IF 0.5 4区 医学 Q4 Medicine Pub Date : 2023-04-07 DOI: 10.37290/ctnr2641-452x.21:117-122
W. A. Mumena, May A. Alsayb
This study aimed to investigate the prevalence and determinants of dietary supplement use in Saudi infants and toddlers. A cross-sectional sample of 156 Saudi infants and toddlers and their mothers who reside in Saudi Arabia was recruited via an online survey that was distributed on multiple social media platforms. Data collected include sociodemographic, maternal height and weight, feeding practices, types, initiation, and frequency of supplements use in infants and toddlers. Sixty-three percent of the infants and toddlers included in this study were using dietary supplements. Over three-quarters of the breastfed infants and toddlers were on dietary supplements. All infants and toddlers who were taking dietary supplements used vitamin D; yet, the use of multivitamins and minerals, iron, and vitamin C supplements was not frequently reported. The use of supplements was significantly higher among infants and toddlers who were the only children in the family and had younger and unemployed mothers. Interventions that target increasing maternal awareness concerning the importance of supplement use among young children in Saudi Arabia are needed.
本研究旨在调查沙特婴幼儿膳食补充剂使用的患病率和决定因素。通过在多个社交媒体平台上发布的在线调查,对居住在沙特阿拉伯的156名沙特婴幼儿及其母亲进行了横断面抽样调查。收集的数据包括社会人口统计、母亲的身高和体重、喂养方法、类型、开始以及婴幼儿使用补充剂的频率。在这项研究中,63%的婴幼儿正在服用膳食补充剂。超过四分之三的母乳喂养的婴幼儿服用膳食补充剂。所有服用膳食补充剂的婴幼儿都服用维生素D;然而,复合维生素和矿物质、铁和维生素C补充剂的使用却很少被报道。在家庭中独生子女的婴儿和学步儿童中,服用补品的比例明显更高,这些孩子的母亲年龄更小,也没有工作。干预措施的目标是提高孕产妇对沙特阿拉伯幼儿服用补充剂重要性的认识。
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引用次数: 0
Nutrition Based on the Traditional Chinese Medicine and Complications of Subclinical Gestational Hypothyroidism 中医营养与亚临床妊娠甲状腺功能减退症并发症
IF 0.5 4区 医学 Q4 Medicine Pub Date : 2023-04-07 DOI: 10.37290/ctnr2641-452x.21:144-149
Mingyue Shen, M. Wu, Jing Gu
We have explored the effect of nutrition management based on the principles of traditional Chinese medicine nutrition on the complications of subclinical gestational hypothyroidism. A total of 228 pregnant women from the Affiliated Hospital of Jiangnan University and the Wuxi Xishan People’s Hospital who were diagnosed with subclinical hypothyroidism between June 2020 and April 2022 were recruited. The patients were divided into the control group (n = 120) and intervention group (n = 108) using the historical control method. The intervention group adopted the traditional Chinese medicine nutrition management model, while the control group was given conventional gestational nutrition management. Iodine nutritional status, maternal and neonatal outcomes, pregnancy complications, pregnancy stress, and social support were compared between the two groups before intervention, at 20 weeks of pregnancy, and before labor. The intervention group had significantly lower iodine nutritional status, better postpartum nutritional status, better pregnancy outcome, lower incidences of pregnancy complications, and better pregnancy stress and social support than in the control group (P < 0.05). In conclusion, traditional Chinese medicine-based nutrition management can effectively control iodine nutritional status, improve maternal and neonatal outcomes, reduce pregnancy complications, and decrease pregnancy stress in postpartum women.
我们探讨了基于中医营养原则的营养管理对亚临床妊娠期甲状腺功能减退症并发症的影响。共招募了228名来自江南大学附属医院和无锡市锡山人民医院的孕妇,她们在2020年6月至2022年4月期间被诊断为亚临床甲状腺功能减退症。采用历史对照法将患者分为对照组(n=120)和干预组(n=108)。干预组采用中药营养管理模式,对照组给予常规妊娠期营养管理。在干预前、妊娠20周和临产前比较两组的碘营养状况、孕产妇和新生儿结局、妊娠并发症、妊娠压力和社会支持。干预组的碘营养状况、产后营养状况、妊娠结局、妊娠并发症发生率、妊娠压力和社会支持均明显低于对照组(P<0.05),改善产妇和新生儿的预后,减少妊娠并发症,减少产后妇女的妊娠压力。
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引用次数: 0
Network Pharmacology-Based Prediction and Experimental Validation of the Targets and Mechanism of Tilianin Action Against Myocardial Infarction 基于网络药理学的Tilianin抗心肌梗死靶点及机制预测与实验验证
IF 0.5 4区 医学 Q4 Medicine Pub Date : 2023-04-07 DOI: 10.37290/ctnr2641-452x.21:150-158
Xiaojing Li, Ning Li, Xiaoyi Yang, Cheng Zeng
Tilianin is a flavonoid glycoside with potential applications in the prevention and treatment of myocardial infarction, but its specific targets and pharmacological mechanisms are unclear. Therefore, in this study, a reverse screening and molecular docking approach was used to predict the pharmacological targets and mechanisms of tilianin on myocardial infarction based on network pharmacology and experimental validation. Firstly, we screened various databases to obtain potential core targets of tilianin. Secondly, we used protein–protein interaction, gene ontology, Kyoto Encyclopedia of Genes and Genomes, and ClueGO to correlate the key targets before molecular docking of new target genes. Finally, the gene expression of tilianin in HL-1 cells was experimentally validated with quantitative real-time polymerase chain reaction and immunofluorescence. The result showed that tilianin may significantly modulate pro-inflammatory effects in the tumor necrosis factor-α signaling pathway, which activates and regulates various cellular activities. Molecular docking revealed that protein kinase B1, proto-oncogene cellular sarcoma, tumor necrosis factor-α, matrix metalloproteinase-9, nitric oxide synthetase 2, mitogen-activated protein kinase 14 and phosphatase and tensin homolog-induced kinase 1 may be the key targets for the systematic regulatory effect of tilianin against myocardial infarction. Finally, quantitative real-time polymerase chain reaction and immunofluorescence results showed that tilianin significantly influences the expression of the key genes in myocardial infarction. Using network bioinformatic analysis, molecular docking techniques, and experimental validation, we predicted and preliminarily validated potential target sites for tilianin. These findings provide a new perspective for further exploration of the mechanism of action of tilianin in myocardial infarction therapy. Meanwhile, this study provides an objective basis for further experimental studies in the future.
Tilianin是一种具有预防和治疗心肌梗死潜力的黄酮类苷类化合物,但其具体作用靶点和药理机制尚不清楚。因此,本研究在网络药理学和实验验证的基础上,采用逆向筛选和分子对接的方法,预测tilianin对心肌梗死的药理靶点和作用机制。首先,我们筛选了各种数据库,获得了tilianin潜在的核心靶点。其次,利用蛋白-蛋白互作、基因本体、京都基因与基因组百科全书、ClueGO等工具,对关键靶点进行关联,然后进行新靶基因的分子对接;最后,采用实时定量聚合酶链反应和免疫荧光技术对HL-1细胞中tilianin基因的表达进行实验验证。结果表明,天青素可显著调节肿瘤坏死因子-α信号通路的促炎作用,激活和调节多种细胞活性。分子对接发现,蛋白激酶B1、原癌细胞肉瘤、肿瘤坏死因子-α、基质金属蛋白酶-9、一氧化氮合成酶2、丝裂原活化蛋白激酶14、磷酸酶和张力素同源诱导激酶1可能是tilianin对心肌梗死系统性调控作用的关键靶点。最后,定量实时聚合酶链反应和免疫荧光结果显示,天青素显著影响心肌梗死关键基因的表达。通过网络生物信息学分析、分子对接技术和实验验证,我们预测并初步验证了tilianin的潜在靶点。这些发现为进一步探索tilianin在心肌梗死治疗中的作用机制提供了新的视角。同时为今后进一步的实验研究提供了客观基础。
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引用次数: 0
Lactobacillus acidophilus Enhances Relief from Clinical Symptoms of Helicobacter pylori Infection in Patients on Quadruple Therapy 嗜酸乳杆菌增强四联疗法患者幽门螺杆菌感染临床症状的缓解
IF 0.5 4区 医学 Q4 Medicine Pub Date : 2023-04-07 DOI: 10.37290/ctnr2641-452x.21:125-130
Hongyan Cai, X. Si
The relief from clinical symptoms of Helicobacter pylori infection caused by Lactobacillus acidophilus treatment was analyzed by a 13C-urea breath test. To this end, 200 patients diagnosed with Helicobacter pylori infection were divided into two equal groups of 100 patients, designated as the control and study groups, respectively. The control group received conventional quadruple therapy that included enteric-coated esomeprazole magnesium tablets, amoxicillin, clarithromycin, and colloidal pectin bismuth for 2 weeks. The study group, in addition to the conventional quadruple therapy, received Lactobacillus acidophilus tablets orally for 2 weeks. The Helicobacter pylori eradication rate (P < 0.05) and total effective rate (P < 0.05) of the study group were higher than the control group. The incidence of adverse reactions including acid reflux, upper abdom¬inal pain, abdominal fullness, and vomiting in the study group was lower (P < 0.05) than the control group. There was no statistically significant difference (P > 0.05) in the levels of tumor nuclear factor-α, high sensitivity C-reaction protein, and interlukin-6 between two groups before treatment. However, the level of these indicators in the study group after treatment was lower than that in the control group. Similarly, there was no statistically significant difference in CD3+, CD4+, CD8+, or CD4+/CD8+ between the two groups before treatment. However, the level of CD3+, CD4+, and CD4+/CD8+ after treatment was significantly higher, while CD8+ was significantly lower in the study group. In conclusion, Lactobacillus acidophilus treat¬ment exhibits a high eradication rate of Helicobacter pylori with good safety and relief from Helicobacter pylori-associated clinical symptoms.
采用13c -尿素呼气试验分析嗜酸乳杆菌治疗幽门螺杆菌感染后临床症状的缓解情况。为此,将200例诊断为幽门螺杆菌感染的患者平均分为两组,每组100例,分别为对照组和研究组。对照组给予肠溶埃索美拉唑镁片、阿莫西林、克拉霉素、胶体果胶铋等常规四联治疗,疗程2周。研究组在常规四联治疗的基础上,口服嗜酸乳杆菌片2周。研究组幽门螺杆菌根除率(P < 0.05)和总有效率(P < 0.05)均高于对照组。研究组胃酸反流、上腹痛、腹胀、呕吐等不良反应发生率低于对照组(P < 0.05)。两组患者治疗前肿瘤核因子-α、高敏c反应蛋白、白介素-6水平比较,差异均无统计学意义(P < 0.05)。但研究组治疗后这些指标水平均低于对照组。同样,两组治疗前CD3+、CD4+、CD8+、CD4+/CD8+比较,差异均无统计学意义。但实验组治疗后CD3+、CD4+、CD4+/CD8+水平明显升高,CD8+水平明显降低。总之,嗜酸乳杆菌治疗幽门螺杆菌根除率高,安全性好,可缓解幽门螺杆菌相关临床症状。
{"title":"Lactobacillus acidophilus Enhances Relief from Clinical Symptoms of Helicobacter pylori Infection in Patients on Quadruple Therapy","authors":"Hongyan Cai, X. Si","doi":"10.37290/ctnr2641-452x.21:125-130","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:125-130","url":null,"abstract":"The relief from clinical symptoms of Helicobacter pylori infection caused by Lactobacillus acidophilus treatment was analyzed by a 13C-urea breath test. To this end, 200 patients diagnosed with Helicobacter pylori infection were divided into two equal groups of 100 patients, designated as the control and study groups, respectively. The control group received conventional quadruple therapy that included enteric-coated esomeprazole magnesium tablets, amoxicillin, clarithromycin, and colloidal pectin bismuth for 2 weeks. The study group, in addition to the conventional quadruple therapy, received Lactobacillus acidophilus tablets orally for 2 weeks. The Helicobacter pylori eradication rate (P < 0.05) and total effective rate (P < 0.05) of the study group were higher than the control group. The incidence of adverse reactions including acid reflux, upper abdom¬inal pain, abdominal fullness, and vomiting in the study group was lower (P < 0.05) than the control group. There was no statistically significant difference (P > 0.05) in the levels of tumor nuclear factor-α, high sensitivity C-reaction protein, and interlukin-6 between two groups before treatment. However, the level of these indicators in the study group after treatment was lower than that in the control group. Similarly, there was no statistically significant difference in CD3+, CD4+, CD8+, or CD4+/CD8+ between the two groups before treatment. However, the level of CD3+, CD4+, and CD4+/CD8+ after treatment was significantly higher, while CD8+ was significantly lower in the study group. In conclusion, Lactobacillus acidophilus treat¬ment exhibits a high eradication rate of Helicobacter pylori with good safety and relief from Helicobacter pylori-associated clinical symptoms.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46112294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Strategies for Cancer Treatment: Anti-Angiogenesis, Exosomes, and micro-RNAs 癌症治疗策略:抗血管生成、外泌体和微rna
IF 0.5 4区 医学 Q4 Medicine Pub Date : 2023-04-07 DOI: 10.37290/ctnr2641-452x.21:123-124
Huangfu Chao, Han-Fang Tseng, Ya-Hsuan Lin, C. Kuo
In this short letter to the editor, we have introduced and summarized the role of anti-angiogenesis, microRNA, and exosomes in cancer treatment strategies.
在这封致编辑的短文中,我们介绍并总结了抗血管生成、microRNA和外泌体在癌症治疗策略中的作用。
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引用次数: 0
Sequential Enteral and Parenteral Nutrition Support Assisted by Nutritional Risk Screening Improves Outcome in the Colorectal Cancer Patients Undergoing Radical Surgery 营养风险筛查辅助的连续性肠外营养支持改善癌症大肠癌根治术患者的预后
IF 0.5 4区 医学 Q4 Medicine Pub Date : 2023-04-07 DOI: 10.37290/ctnr2641-452x.21:159-162
Jing Gao, Tiansheng Xu, Li’an Xu, C-W Mao, Yujin Feng
We have examined the influence of sequential enteral and parenteral nutrition support, assisted by nutritional risk screening, on colorectal cancer patients undergoing radical surgery. This cohort included 100 colorectal cancer patients receiving radical surgery in Zhejiang Quzhou People’s Hospital between May 2021 and April 2022. The control group received treat¬ment with early enteral nutrition support only. The experimental group, however, received sequential enteral and parenteral nutrition support, assisted by nutritional risk screening. The indicators of nutrition adequacy, gastrointestinal function, early postoperative complications, and quality of life were compared. The albumin, hemoglobin, and albumin levels presented no difference between the two groups before treatment. After treatment, these indicators in the experimental group were elevated relative to those in the control group. The time of bowel sound recovery, the time of first anal exhaustion, time of first defecation, and the incidence of surgical complications in the experimental group decreased relative to those in the control group. A 36-item short-form health survey showed an elevation in the experimental group relative to the control group. Application of sequential enteral and parenteral nutritional support assisted by nutritional risk screening in colorectal cancer patients has a significant effect, which helps improve postoperative nutritional status, facilitate gastrointestinal function recovery, reduce incidence of complications, and accelerate postoperative recovery.
我们研究了在营养风险筛查的辅助下,顺序肠内和肠外营养支持对癌症根治性手术患者的影响。该队列包括2021年5月至2022年4月在浙江省衢州市人民医院接受根治性手术的100名癌症患者。对照组仅接受早期肠内营养支持治疗。然而,实验组接受了连续的肠内和肠外营养支持,并辅以营养风险筛查。比较营养充足率、胃肠功能、术后早期并发症和生活质量等指标。治疗前两组的白蛋白、血红蛋白和白蛋白水平无差异。治疗后,实验组的这些指标相对于对照组有所升高。与对照组相比,实验组的肠鸣音恢复时间、首次肛门衰竭时间、首次排便时间和手术并发症发生率均有所下降。一项36项的简短健康调查显示,与对照组相比,实验组的健康状况有所改善。营养风险筛查辅助肠外营养支持在癌症大肠癌患者中的应用效果显著,有助于改善术后营养状况,促进胃肠功能恢复,降低并发症发生率,加快术后恢复。
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引用次数: 0
Extraction and Compositional Analysis of Anthocyanins and Polysaccharides from Aronia Melanocarpa Fruit 黑桫椤果实中花青素和多糖的提取及成分分析
4区 医学 Q4 Medicine Pub Date : 2023-03-30 DOI: 10.37290/ctnr2641-452x.21:495-501
Chu-yan Wang, Dong-sheng Wang, Jie Wu, Xia-wei Yin, Ze-hui Wang, Ye-xian Hu, Yan Zhang, Rong-an Zhu, Hong Mei
We have examined the basic composition of anthocyanins and polysaccharides, the active components in Aronia melanocarpa fruit. To this end, microwave-assisted ethanol extraction and cellulase enzymatic hydrolysis were employed to extract anthocyanins and crude polysaccharides, respectively. Aronia melanocarpa fruit polysaccharides were separated and purified by DEAE-52 cellulose and Sephadex G-100 glucan gel column chromatography, followed by high-performance liquid chromatography. The results demonstrated that the optimal extraction parameters of anthocyanin from Aronia melanocarpa fruit were a 60% ethanol volume fraction, a liquid-to-solid ratio of 30:1, a microwave time of 60 s, and a microwave power of 210 W. The extracted anthocyanins reached 200.47 mg/100 g, while the yield of polysaccharides was 3.82%. Anthocyanins in Aronia melanocarpa fruit were mainly composed of cyanidin, delphinidin, and mallow pigment, among which cyanidin was the main component, with a content as high as 90.79%. There were two distinct fractions of polysaccharides. The fraction-I polysaccharides were mainly composed of rhamnose, galacturonic acid, glucose, galactose, and arabinose, with a molar ratio of 8.80: 8.97: 2.38: 27.46: 47.94. In contrast, the fraction-II polysaccharides were primarily composed of rhamnose, glucuronic acid, galactose, xylose, and arabinose, with a molar ratio of 1.67: 9.22: 8.47: 70.69: 6.16. The results of this study can provide a reference for the in-depth development of Aronia melanocarpa resources
本文研究了黑桫椤果实中有效成分花青素和多糖的基本组成。为此,采用微波辅助乙醇提取法和纤维素酶水解法分别提取花青素和粗多糖。采用DEAE-52纤维素和Sephadex G-100葡聚糖凝胶柱层析对黑桃果多糖进行分离纯化,然后采用高效液相色谱法。结果表明,提取黑果野莓果实花青素的最佳工艺参数为乙醇体积分数60%、液料比30:1、微波时间60 s、微波功率210 W。花青素提取率为200.47 mg/100 g,多糖得率为3.82%。黑果野樱草果实中的花青素主要由花青素、飞燕素和锦葵色素组成,其中花青素为主要成分,含量高达90.79%。多糖有两个不同的组分。部分i多糖主要由鼠李糖、半乳糖醛酸、葡萄糖、半乳糖和阿拉伯糖组成,摩尔比为8.80:8.97:2.38:27.46:47.94。ⅱ段多糖主要由鼠李糖、葡萄糖醛酸、半乳糖、木糖和阿拉伯糖组成,摩尔比为1.67:9.22:8.47:70.69:6.16。本研究结果可为黑檀资源的深入开发提供参考
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引用次数: 0
Polyphenols from Moringa Oleifera and Mulberry Exhibit Anti-Obesity and Anti-Hyperlipidemic Effects in Rats Fed a High-Fat Diet 辣木和桑多酚在高脂肪饮食大鼠中表现出抗肥胖和抗高脂血症的作用
IF 0.5 4区 医学 Q4 Medicine Pub Date : 2023-01-11 DOI: 10.37290/ctnr2641-452x.21:102-108
R. Alqurashi, Mariam Alholaibi
This study investigated the effects of Moringa oleifera leaf, mulberry fruit, and mulberry leaf on high-fat diet-induced changes in body weight and hyperlipidemia in rats. Healthy male rats were randomly divided into five equal-sized groups that included (i) basal diet or negative control group, (ii) high-fat diet group (basal diet + 20% fat), (iii) M. oleifera leaf-treated high-fat diet group (high-fat diet + 10% M. oleifera leaf), (iv) mulberry fruit-treated high-fat diet group (high-fat diet + 10% mulberry fruit), and (v) mulberry leaf-treated high-fat diet group (high-fat diet + 10% mulberry leaf). The rats were treated daily for 6 weeks, and body weight data and blood samples were collected for each group. At the end of the study period, body weight, total cholesterol, total triglyceride, low-density lipoprotein level, and glucose level were significantly reduced in the rats fed a high-fat diet supplemented with M. oleifera leaf, mulberry fruit, or mulberry leaf. Moreover, serum high-density lipoprotein was significantly elevated in the rats on a high-fat diet receiving M. oleifera leaf or mulberry fruit. The antiobesity and antihyperlipidemic effects of M. oleifera leaf, mulberry fruit, and mulberry leaf provide support for the use of Moringa and mulberry as potential functional food ingredients for the prevention of obesity and hyperlipidemia.
本研究探讨了辣木叶、桑葚果和桑叶对高脂肪饮食诱导的大鼠体重和高脂血症的影响。将健康雄性大鼠随机分为5个等量组,分别为:(i)基础饲粮或阴性对照组,(ii)高脂肪饲粮组(基础饲粮+ 20%脂肪),(iii)油棕叶处理高脂肪饲粮组(高脂肪饲粮+ 10%油棕叶),(iv)桑果处理高脂肪饲粮组(高脂肪饲粮+ 10%桑叶),(v)桑叶处理高脂肪饲粮组(高脂肪饲粮+ 10%桑叶)。每天给药6周,收集各组大鼠体重数据和血液样本。研究结束时,在高脂肪饮食中添加油橄榄叶、桑葚果或桑叶的大鼠体重、总胆固醇、总甘油三酯、低密度脂蛋白水平和葡萄糖水平显著降低。此外,高脂饮食中食用油叶或桑果的大鼠血清高密度脂蛋白显著升高。辣木叶、桑果和桑叶的抗肥胖和降血脂作用为辣木和桑树作为预防肥胖和高脂血症的潜在功能性食品成分提供了支持。
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引用次数: 0
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Current Topics in Nutraceutical Research
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