Pub Date : 2023-01-06DOI: 10.37290/ctnr2641-452x.21:94-101
Zunping Wu, Yanzhe Xu, Ruoyu Zhou, Hao Liu, Hua Ling, Yimei Du, Yanliu Lu, Yuqi He
We have examined the effect of gypenosides on hepatic lipid metabolism in hyperlipidemic mice. To this end, male mice were placed on a high-fat diet and then administered gypenosides. Compared to the mice on the high-fat diet, the levels of liver index, total cholesterol, and low-density lipoprotein cholesterol in the serum were significantly reduced by gypenoside treatment. Gypenosides influenced the overall profile of 22 hepatic fatty acid metabolism genes significantly. Three genes, Cyp4a10, Cyp4a14, and Cyp4a31, had their mRNA expression altered by about tenfold. As a possible mechanism, the findings suggest that gypenosides regulate lipid homeostasis by influencing fatty acid metabolism and promoting fatty acid ω-oxidation.
{"title":"Gypenosides Improve Lipid Homeostasis by Regulating Fatty Acid Metabolism in the Liver","authors":"Zunping Wu, Yanzhe Xu, Ruoyu Zhou, Hao Liu, Hua Ling, Yimei Du, Yanliu Lu, Yuqi He","doi":"10.37290/ctnr2641-452x.21:94-101","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:94-101","url":null,"abstract":"We have examined the effect of gypenosides on hepatic lipid metabolism in hyperlipidemic mice. To this end, male mice were placed on a high-fat diet and then administered gypenosides. Compared to the mice on the high-fat diet, the levels of liver index, total cholesterol, and low-density lipoprotein cholesterol in the serum were significantly reduced by gypenoside treatment. Gypenosides influenced the overall profile of 22 hepatic fatty acid metabolism genes significantly. Three genes, Cyp4a10, Cyp4a14, and Cyp4a31, had their mRNA expression altered by about tenfold. As a possible mechanism, the findings suggest that gypenosides regulate lipid homeostasis by influencing fatty acid metabolism and promoting fatty acid ω-oxidation.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46861564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-06DOI: 10.37290/ctnr2641-452x.21:86-93
Lina Wu, Zhen Chen
Glaucoma is a progressive neurodegenerative eye disease characterized by raised intraocular pressure and a loss of retinal ganglion cells, resulting in partial or total vision loss. We have investigated whether paeoniflorin could reduce intraocular pressure and improve retinal ganglion cell survival in glaucoma-induced rats. In rats with raised intraocular pressure induced by injecting hypertonic saline solution into the limbal veins, oral paeoniflorin markedly brought down the elevated intraocular pressure and significantly prevented retinal ganglion cell loss, as determined by the terminal deoxynucleotidyl transferase dUTP nick end labeling assay and Fluoro-Gold labeling. The expression of the transforming growth factor β protein was effectively diminished by paeoniflorin administration. Also, the expression of extracellular matrix components matrix metalloproteinase 9 a tissue inhibitor of metalloproteinase 1—laminin, collagen I, and collagen IV in the optic nerve head and retinal ganglion cell layer were effectively diminished. Paeoniflorin substantially upregulated the activation of Janus kinase-2/signal transducer and activator of transcription proteins-3 signaling, which plays a crucial role in retinal ganglion cell survival. These results illustrate a protective effect of paeoniflorin through reduction of intraocular pressure, retinal ganglion cell loss, and changes in the extracellular matrix by regulating transforming growth factor β2 signaling and Janus kinase-2/signal transducer and activator of transcription protein-3 signaling. The present work demonstrates that paeoniflorin may be a promising therapeutic agent for glaucoma.
{"title":"Paeoniflorin Protects Retinal Ganglion Cells in Experimental Glaucoma","authors":"Lina Wu, Zhen Chen","doi":"10.37290/ctnr2641-452x.21:86-93","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:86-93","url":null,"abstract":"Glaucoma is a progressive neurodegenerative eye disease characterized by raised intraocular pressure and a loss of retinal ganglion cells, resulting in partial or total vision loss. We have investigated whether paeoniflorin could reduce intraocular pressure and improve retinal ganglion cell survival in glaucoma-induced rats. In rats with raised intraocular pressure induced by injecting hypertonic saline solution into the limbal veins, oral paeoniflorin markedly brought down the elevated intraocular pressure and significantly prevented retinal ganglion cell loss, as determined by the terminal deoxynucleotidyl transferase dUTP nick end labeling assay and Fluoro-Gold labeling. The expression of the transforming growth factor β protein was effectively diminished by paeoniflorin administration. Also, the expression of extracellular matrix components matrix metalloproteinase 9 a tissue inhibitor of metalloproteinase 1—laminin, collagen I, and collagen IV in the optic nerve head and retinal ganglion cell layer were effectively diminished. Paeoniflorin substantially upregulated the activation of Janus kinase-2/signal transducer and activator of transcription proteins-3 signaling, which plays a crucial role in retinal ganglion cell survival. These results illustrate a protective effect of paeoniflorin through reduction of intraocular pressure, retinal ganglion cell loss, and changes in the extracellular matrix by regulating transforming growth factor β2 signaling and Janus kinase-2/signal transducer and activator of transcription protein-3 signaling. The present work demonstrates that paeoniflorin may be a promising therapeutic agent for glaucoma.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48366650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-01-06DOI: 10.37290/ctnr2641-452x.21:80-85
Yi Zhang, Xu Wang, Yiwen Yang, Ya-qin Wei, Li Sheng, Lu Yu
Diabetic gastroparesis is a common complication of diabetes that may lead to poor nutrition, problems managing blood glucose, and a reduced quality of life. Jiawei Sijunzi soup has been shown to benefit patients with amyotrophic lateral sclerosis while causing no serious side effects. In this study, we investigated the possible effects of Jiawei Sijunzi soup on the progression of diabetic gastroparesis in a rat model induced by streptozotocin. The results show that Jiawei Sijunzi soup reduced inflammation and oxidative stress and improved the pathological features of gastric tissue in diabetic gastroparesis. The target of Jiawei Sijunzi soup in diabetic gastroparesis was analyzed based on network pharmacology and molecular docking techniques. The results show activation of the PI3K/AKT pathway by Jiawei Sijunzi soup in the rat model of diabetic gastroparesis.
{"title":"Jiawei Sijunzi Soup Inhibits Inflammation and Oxidative Stress in the Rat Model of Diabetic Gastroparesis","authors":"Yi Zhang, Xu Wang, Yiwen Yang, Ya-qin Wei, Li Sheng, Lu Yu","doi":"10.37290/ctnr2641-452x.21:80-85","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:80-85","url":null,"abstract":"Diabetic gastroparesis is a common complication of diabetes that may lead to poor nutrition, problems managing blood glucose, and a reduced quality of life. Jiawei Sijunzi soup has been shown to benefit patients with amyotrophic lateral sclerosis while causing no serious side effects. In this study, we investigated the possible effects of Jiawei Sijunzi soup on the progression of diabetic gastroparesis in a rat model induced by streptozotocin. The results show that Jiawei Sijunzi soup reduced inflammation and oxidative stress and improved the pathological features of gastric tissue in diabetic gastroparesis. The target of Jiawei Sijunzi soup in diabetic gastroparesis was analyzed based on network pharmacology and molecular docking techniques. The results show activation of the PI3K/AKT pathway by Jiawei Sijunzi soup in the rat model of diabetic gastroparesis.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44708247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-26DOI: 10.37290/ctnr2641-452x.21:47-52
Lin Kong, Jie Kong, Zhihong Chai, Guo‐Xian Tao, Xianli Cai, Lingxiao Ying, Jinmei Shi
This study was performed to investigate the effects of Lactobacillus vaginal capsules combined with recombinant human interferon α-2b gel on clinical efficacy, vaginal microbial function indicators, vaginal microecological balance, inflammation levels, and drug safety in patients with persistent cervical high-risk human papillomavirus infection. Patients with human papillomavirus infection (n = 128) were randomly divided into control and observation groups of equal size. Patients in the control group were treated with recombinant human interferon α-2b gel alone. Patients in the observation group were treated with Lactobacillus vaginal capsules and human interferon α-2b gel. After treatment, the clinical efficiency, microbial function index, and human papillomavirus-DNA conversion rate of patients in the observation group were significantly higher than those in the control group. Further, pH, Nugent scores, human papillomavirus-DNA viral load, vaginal microecological dysregulation rate, and inflammation level were significantly lower than those in the control group. Lactobacillus vaginal capsules in combination with recombinant human interferon α-2b gel improved clinical outcomes and disease regression rates in patients with human papillomavirus infection, while also improving vaginal microecological balance and suppressing inflammatory responses.
{"title":"Recombinant Interferon α-2B Gel Combined with Lactobacillus as a Vaginal Capsule in Patients with Cervical High-Risk Human Papillomavirus","authors":"Lin Kong, Jie Kong, Zhihong Chai, Guo‐Xian Tao, Xianli Cai, Lingxiao Ying, Jinmei Shi","doi":"10.37290/ctnr2641-452x.21:47-52","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:47-52","url":null,"abstract":"This study was performed to investigate the effects of Lactobacillus vaginal capsules combined with recombinant human interferon α-2b gel on clinical efficacy, vaginal microbial function indicators, vaginal microecological balance, inflammation levels, and drug safety in patients with persistent cervical high-risk human papillomavirus infection. Patients with human papillomavirus infection (n = 128) were randomly divided into control and observation groups of equal size. Patients in the control group were treated with recombinant human interferon α-2b gel alone. Patients in the observation group were treated with Lactobacillus vaginal capsules and human interferon α-2b gel. After treatment, the clinical efficiency, microbial function index, and human papillomavirus-DNA conversion rate of patients in the observation group were significantly higher than those in the control group. Further, pH, Nugent scores, human papillomavirus-DNA viral load, vaginal microecological dysregulation rate, and inflammation level were significantly lower than those in the control group. Lactobacillus vaginal capsules in combination with recombinant human interferon α-2b gel improved clinical outcomes and disease regression rates in patients with human papillomavirus infection, while also improving vaginal microecological balance and suppressing inflammatory responses.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48252207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-10-06DOI: 10.37290/ctnr2641-452x.21:38-39
Chih-Hung Lin, Han-Fang Tseng, Chang-Ti Lee, C. Kuo
6-MSITC (Methylsulfinyl hexyl isothiocyanate) is a bioactive compound found in wasabi that contains anti-inflammatory, anti-carcinogenic, and antioxidative properties. In this article, we summarize and discuss the current studies on the role of 6-MSITC on inflammatory diseases and carcinogenesis.
{"title":"6-(Methylsulfinyl) Hexyl Isothiocyanate from Wasabia Japonica for Inflammatory Diseases and Carcinogenesis","authors":"Chih-Hung Lin, Han-Fang Tseng, Chang-Ti Lee, C. Kuo","doi":"10.37290/ctnr2641-452x.21:38-39","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:38-39","url":null,"abstract":"6-MSITC (Methylsulfinyl hexyl isothiocyanate) is a bioactive compound found in wasabi that contains anti-inflammatory, anti-carcinogenic, and antioxidative properties. In this article, we summarize and discuss the current studies on the role of 6-MSITC on inflammatory diseases and carcinogenesis.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43402750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-09-06DOI: 10.37290/ctnr2641-452x.21:31-37
Chuanyang Dai, Guofeng Wu
Ligustilide is a bioactive component of the traditional Chinese herb Angelica sinensis that exhibits analgesic, anti-inflammatory, anticancer, neuroprotection, and anti-atherosclerosis pharmacological activities. Herein, the role of ligustilide in intracerebral hemorrhage-induced cardiac damage has been assessed. An autologous blood injection was used to induce intracerebral hemorrhage in CD-1 mice that resulted in an increase in systolic and diastolic blood pressure. Intraperitoneal administration of ligustilide reduced systolic and diastolic blood pressure, decreased plasma levels of adrenaline and noradrenaline in mice with intracerebral hemorrhage. Also, cardiac injury was observed in mice with intracerebral hemorrhage, as demonstrated by the upregulation of creatine kinase-MB, lactic dehydrogenase, and aspartate transaminase. Moreover, Picrosirius red staining showed cardiac fibrosis in intracerebral hemorrhage mice that was attenuated by ligustilide. Lastly, ligustilide reduced levels of interleukin-1β, tumor necrosis factor-α, interleukin-6, and reactive oxygen species in mice with intracerebral hemorrhage. Cardiac apoptosis in mice with intracerebral hemorrhage was also inhibited by ligustilide, as shown by reduced protein expression of phospho-p65, enhanced nuclear factor erythroid 2-related factor 2, and heme oxygenase-1 expression.
{"title":"Ligustilide Attenuates Intracerebral Hemorrhage-Induced Cardiac Damage via Nuclear Factor-Kappa B and Nuclear-Factor Erythroid 2-Related Factor 2 Pathways","authors":"Chuanyang Dai, Guofeng Wu","doi":"10.37290/ctnr2641-452x.21:31-37","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:31-37","url":null,"abstract":"Ligustilide is a bioactive component of the traditional Chinese herb Angelica sinensis that exhibits analgesic, anti-inflammatory, anticancer, neuroprotection, and anti-atherosclerosis pharmacological activities. Herein, the role of ligustilide in intracerebral hemorrhage-induced cardiac damage has been assessed. An autologous blood injection was used to induce intracerebral hemorrhage in CD-1 mice that resulted in an increase in systolic and diastolic blood pressure. Intraperitoneal administration of ligustilide reduced systolic and diastolic blood pressure, decreased plasma levels of adrenaline and noradrenaline in mice with intracerebral hemorrhage. Also, cardiac injury was observed in mice with intracerebral hemorrhage, as demonstrated by the upregulation of creatine kinase-MB, lactic dehydrogenase, and aspartate transaminase. Moreover, Picrosirius red staining showed cardiac fibrosis in intracerebral hemorrhage mice that was attenuated by ligustilide. Lastly, ligustilide reduced levels of interleukin-1β, tumor necrosis factor-α, interleukin-6, and reactive oxygen species in mice with intracerebral hemorrhage. Cardiac apoptosis in mice with intracerebral hemorrhage was also inhibited by ligustilide, as shown by reduced protein expression of phospho-p65, enhanced nuclear factor erythroid 2-related factor 2, and heme oxygenase-1 expression.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41816058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-23DOI: 10.37290/ctnr2641-452x.21:53-59
Ying-Li Dong, Weiqian Hou, Chong Zhang, Xiaozhong Cao, Zhen-Yu Li
While radiotherapy remains the cornerstone of head and neck cancer treatment, oral mucositis is a very serious side effect, especially grade III/IV oral mucositis. Oral mucositis not only seriously reduces the quality of life of patients, but also affects the ongoing treatment of patients. Use of honey for the remediation of oral mucositis promising, but clinically controversial. Therefore, to further ascertain its role in oral mucositis, an extensive literature search was performed in the Pubmed, Embase and Cochrane databases. Thirteen randomized controlled trials with 899 patients were included in the analysis. Pooled Odds ratio with 95% confidence intervals was analyzed. The results show that a significantly fewer number of patients treated with honey experienced grade III/IV oral mucositis after radiotherapy (OR 0.24, 95% CI 0.13–0.44, p < 0.001). The administration of honey concurrently with radiotherapy decreased the rate of graded III/IV oral mucositis. Thus, the use of honey during radiotherapy may represent a feasible strategy for preserving tolerance.
{"title":"Effectiveness of Honey on Radiation-Induced Oral Mucositis Among Patients with Head and Neck Malignancies: A Systematic Review and Meta-Analysis","authors":"Ying-Li Dong, Weiqian Hou, Chong Zhang, Xiaozhong Cao, Zhen-Yu Li","doi":"10.37290/ctnr2641-452x.21:53-59","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:53-59","url":null,"abstract":"While radiotherapy remains the cornerstone of head and neck cancer treatment, oral mucositis is a very serious side effect, especially grade III/IV oral mucositis. Oral mucositis not only seriously reduces the quality of life of patients, but also affects the ongoing treatment of patients. Use of honey for the remediation of oral mucositis promising, but clinically controversial. Therefore, to further ascertain its role in oral mucositis, an extensive literature search was performed in the Pubmed, Embase and Cochrane databases. Thirteen randomized controlled trials with 899 patients were included in the analysis. Pooled Odds ratio with 95% confidence intervals was analyzed. The results show that a significantly fewer number of patients treated with honey experienced grade III/IV oral mucositis after radiotherapy (OR 0.24, 95% CI 0.13–0.44, p < 0.001). The administration of honey concurrently with radiotherapy decreased the rate of graded III/IV oral mucositis. Thus, the use of honey during radiotherapy may represent a feasible strategy for preserving tolerance.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43998822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-10DOI: 10.37290/ctnr2641-452x.21:18-24
Yaping Zhao, Xia Gao
The regulatory role of coptisine on autophagy in cervical cancer cells (in HcerEpic, HeLa, and SiHa) was examined by assessment of cell viability, colony formation, and apoptosis. Coptisine, in a dose-dependent fashion, significantly inhibited cervical cancer cell viability as measured by cell proliferation, transwell, and TUNEL assays. Coptisine inhibited the levels of p62 and Bcl-2, whilst it promoted the accumulation of Atg5, LC3Ⅱ/LC3Ⅰ and Bax. These data taken together suggest that coptisine inhibits the progression of cervical cancer cells by enhancing autophagy through suppression of the PI3K/AKT/mTOR pathway. This represents a theoretical foundation for developing novel cervical cancer treatments.
{"title":"Coptisine Reduces the Progression of Cervical Cancer Through Induction of Autophagy","authors":"Yaping Zhao, Xia Gao","doi":"10.37290/ctnr2641-452x.21:18-24","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:18-24","url":null,"abstract":"The regulatory role of coptisine on autophagy in cervical cancer cells (in HcerEpic, HeLa, and SiHa) was examined by assessment of cell viability, colony formation, and apoptosis. Coptisine, in a dose-dependent fashion, significantly inhibited cervical cancer cell viability as measured by cell proliferation, transwell, and TUNEL assays. Coptisine inhibited the levels of p62 and Bcl-2, whilst it promoted the accumulation of Atg5, LC3Ⅱ/LC3Ⅰ and Bax. These data taken together suggest that coptisine inhibits the progression of cervical cancer cells by enhancing autophagy through suppression of the PI3K/AKT/mTOR pathway. This represents a theoretical foundation for developing novel cervical cancer treatments.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42678785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-08-08DOI: 10.37290/ctnr2641-452x.20:662-665
M-Y Sung, Kuo-Hung Liao, Jiunn-Sheng Wu, I-Shing Tzeng, Lou Sun, C. Kuo
Interactions of platelets with circulating cells and vessel walls are implicated in various inflammatory processes. In certain circumstances, the hemostatic and inflammatory functions of platelets may overlap. Platelet–lymphocyte/leukocyte interactions can effectively regulate chronic inflammatory conditions. Platelet extracellular vesicles play a prominent role in thrombosis. In this review, we provide an overview of the molecules associated with platelet–cell interaction and the role of platelet extracellular vesicles in cardiovascular disorders and coronavirus disease 2019, which has posed a significant threat to global health due to infection with severe acute respiratory syndrome coronavirus 2. In addition to recruiting leukocytes to resolve inflammation associated with inflammatory diseases, such as coronavirus disease 2019, nutrients may also play a significant role in human metabolism.
{"title":"Role of Nutrients on Platelets Participation in Leukocyte Recruitment and Inflammation Resolution in Inflammatory Diseases, Including Covid-19","authors":"M-Y Sung, Kuo-Hung Liao, Jiunn-Sheng Wu, I-Shing Tzeng, Lou Sun, C. Kuo","doi":"10.37290/ctnr2641-452x.20:662-665","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.20:662-665","url":null,"abstract":"Interactions of platelets with circulating cells and vessel walls are implicated in various inflammatory processes. In certain circumstances, the hemostatic and inflammatory functions of platelets may overlap. Platelet–lymphocyte/leukocyte interactions can effectively regulate chronic inflammatory conditions. Platelet extracellular vesicles play a prominent role in thrombosis. In this review, we provide an overview of the molecules associated with platelet–cell interaction and the role of platelet extracellular vesicles in cardiovascular disorders and coronavirus disease 2019, which has posed a significant threat to global health due to infection with severe acute respiratory syndrome coronavirus 2. In addition to recruiting leukocytes to resolve inflammation associated with inflammatory diseases, such as coronavirus disease 2019, nutrients may also play a significant role in human metabolism.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49358756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-25DOI: 10.37290/ctnr2641-452x.21:1-9
Jingyuan Zhang, Dongqing Yang, Juan Zhao, Yun Ling, Chunxiang Zhou
Alzheimer’s disease is a common neurodegenerative disorder. Ling-Gui-Zhu-Gan decoction has anti-inflammatory, anti-tumor, and immune-regulating effects and is a representative agent for strengthening the spleen and promoting water retention. The present study aimed to investigate the underlying mechanism of Ling-Gui-Zhu-Gan decoction in alleviating Alzheimer’s disease. Alzheimer’s disease in vitro and in vivo models were constructed by exposing SH-SY5Y cells to β-amyloid 1-42 and injecting β-amyloid 1-42 into Sprague-Dawley rats, respectively. The Morris water maze test was used to assess cognitive decline in rats. Cell counting kit-8, flow cytometry analysis, and enzyme-linked immunosorbent assay were conducted to determine cell viability, apoptosis, and inflammation. β-amyloid 1-42 treatment induced SH-SY5Y cell apoptosis, evoked inflammation response and oxidative stress while hindering cell proliferation. Ling-Gui-Zhu-Gan decoction antagonized the effect of β-amyloid 1-42 on SH-SY5Y cells by activating the nuclear factor erythroid 2-related factor 2/antioxidant response element signaling pathway. In addition, Ling-Gui-Zhu-Gan decoction improved memory and learning abilities and alleviated neuropathologic lesions, inflammation response, and neurotoxicity in Alzheimer’s disease rats in a dose-dependent manner by upregulating nuclear factor erythroid 2-related factor 2/antioxidant response element pathway. The Ling-Gui-Zhu-Gan decoction improved the spatial learning and memory ability of Alzheimer’s disease rats by upregulating the nuclear factor erythroid 2-related factor 2/antioxidant response element signaling pathway to counteract the imbalance in the body’s oxidative stress levels and the damage caused by neuroinflammation.
{"title":"Ling-Gui-Zhu-Gan Decoction Alleviates Cognitive Deficits in Alzheimer’s Disease by Activating the Nuclear Factor-Erythroid Factor 2-Related Factor 2/The Antioxidant Responsive Element Signaling Pathway","authors":"Jingyuan Zhang, Dongqing Yang, Juan Zhao, Yun Ling, Chunxiang Zhou","doi":"10.37290/ctnr2641-452x.21:1-9","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:1-9","url":null,"abstract":"Alzheimer’s disease is a common neurodegenerative disorder. Ling-Gui-Zhu-Gan decoction has anti-inflammatory, anti-tumor, and immune-regulating effects and is a representative agent for strengthening the spleen and promoting water retention. The present study aimed to investigate the underlying mechanism of Ling-Gui-Zhu-Gan decoction in alleviating Alzheimer’s disease. Alzheimer’s disease in vitro and in vivo models were constructed by exposing SH-SY5Y cells to β-amyloid 1-42 and injecting β-amyloid 1-42 into Sprague-Dawley rats, respectively. The Morris water maze test was used to assess cognitive decline in rats. Cell counting kit-8, flow cytometry analysis, and enzyme-linked immunosorbent assay were conducted to determine cell viability, apoptosis, and inflammation. β-amyloid 1-42 treatment induced SH-SY5Y cell apoptosis, evoked inflammation response and oxidative stress while hindering cell proliferation. Ling-Gui-Zhu-Gan decoction antagonized the effect of β-amyloid 1-42 on SH-SY5Y cells by activating the nuclear factor erythroid 2-related factor 2/antioxidant response element signaling pathway. In addition, Ling-Gui-Zhu-Gan decoction improved memory and learning abilities and alleviated neuropathologic lesions, inflammation response, and neurotoxicity in Alzheimer’s disease rats in a dose-dependent manner by upregulating nuclear factor erythroid 2-related factor 2/antioxidant response element pathway. The Ling-Gui-Zhu-Gan decoction improved the spatial learning and memory ability of Alzheimer’s disease rats by upregulating the nuclear factor erythroid 2-related factor 2/antioxidant response element signaling pathway to counteract the imbalance in the body’s oxidative stress levels and the damage caused by neuroinflammation.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2022-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44115203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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