Pub Date : 1900-01-01DOI: 10.1364/boda.2023.jtu4b.28
Rodrigo Itzamná Becerra Deana, R. Maltais-Tariant, Simon Brais-Brunet, S. Virally, N. Godbout, C. Boudoux
Few-mode optical coherence tomography collects and exploits higher-order modes for added signal and contrast. A new photonics lantern at 1300 nm highlights structural differences between the head and tail regions of a zebrafish in vivo.
{"title":"Few-Mode Optical Coherence Tomography at 1300 nm for in vivo Imaging","authors":"Rodrigo Itzamná Becerra Deana, R. Maltais-Tariant, Simon Brais-Brunet, S. Virally, N. Godbout, C. Boudoux","doi":"10.1364/boda.2023.jtu4b.28","DOIUrl":"https://doi.org/10.1364/boda.2023.jtu4b.28","url":null,"abstract":"Few-mode optical coherence tomography collects and exploits higher-order modes for added signal and contrast. A new photonics lantern at 1300 nm highlights structural differences between the head and tail regions of a zebrafish in vivo.","PeriodicalId":111173,"journal":{"name":"Biophotonics Congress: Optics in the Life Sciences 2023 (OMA, NTM, BODA, OMP, BRAIN)","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132890895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.1364/boda.2023.dth2a.2
D. Borycki, P. Węgrzyn, Auksorius Egidijus, Wiktor M. Kulesza, S. Tomczewski, A. Curatolo, M. Wojtkowski
We developed and applied spatio-temporal optical coherence tomography (STOC-T), which supported by computational aberration correction enables high resolution imaging of the human and mouse retina in vivo.
{"title":"Spatio-temporal optical coherence tomography (STOC-T) for high-resolution imaging of the human and mouse retina in vivo","authors":"D. Borycki, P. Węgrzyn, Auksorius Egidijus, Wiktor M. Kulesza, S. Tomczewski, A. Curatolo, M. Wojtkowski","doi":"10.1364/boda.2023.dth2a.2","DOIUrl":"https://doi.org/10.1364/boda.2023.dth2a.2","url":null,"abstract":"We developed and applied spatio-temporal optical coherence tomography (STOC-T), which supported by computational aberration correction enables high resolution imaging of the human and mouse retina in vivo.","PeriodicalId":111173,"journal":{"name":"Biophotonics Congress: Optics in the Life Sciences 2023 (OMA, NTM, BODA, OMP, BRAIN)","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134638707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.1364/ntm.2023.ntu2c.5
Yuxiao Wei, I. Pence, Conor L. Evans
Pharmaceutical development of solid-state formulations requires testing for uniformity and active pharmaceutical ingredient stability. We demonstrate fast chemical imaging by epi-detected sparse spectral sampling stimulated Raman scattering to quantify API and excipient degradation and distribution.
{"title":"Quantitative analysis of drug tablet aging by fast hyperspectral stimulated Raman scattering microscopy","authors":"Yuxiao Wei, I. Pence, Conor L. Evans","doi":"10.1364/ntm.2023.ntu2c.5","DOIUrl":"https://doi.org/10.1364/ntm.2023.ntu2c.5","url":null,"abstract":"Pharmaceutical development of solid-state formulations requires testing for uniformity and active pharmaceutical ingredient stability. We demonstrate fast chemical imaging by epi-detected sparse spectral sampling stimulated Raman scattering to quantify API and excipient degradation and distribution.","PeriodicalId":111173,"journal":{"name":"Biophotonics Congress: Optics in the Life Sciences 2023 (OMA, NTM, BODA, OMP, BRAIN)","volume":"31 7-8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134461627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
We improve imaging performance of light sheet microscopy with laser illumination by applying a frosted glass scatter to realize decoherence so that avoiding laser speckle effect and using the Kohler illumination to improve light uniformity.
{"title":"Light Sheet Microscope with Incoherent Uniform Illumination","authors":"Jingran Dong, Zhenzhen Lu, Hongyi Pan, Jihong Feng","doi":"10.1364/ntm.2023.nm3c.4","DOIUrl":"https://doi.org/10.1364/ntm.2023.nm3c.4","url":null,"abstract":"We improve imaging performance of light sheet microscopy with laser illumination by applying a frosted glass scatter to realize decoherence so that avoiding laser speckle effect and using the Kohler illumination to improve light uniformity.","PeriodicalId":111173,"journal":{"name":"Biophotonics Congress: Optics in the Life Sciences 2023 (OMA, NTM, BODA, OMP, BRAIN)","volume":"97 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132055170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
V. Svak, O. Brzobohatý, V. Liska, Y. Arita, M. Šiler, P. Jákl, J. Kaňka, SH Simpson, Emily S Wright, G. Bruce, K. Dholakia, P. Zemánek
We describe the general stochastic motion of linearly non-conservative optomechanical systems, levitated in vacuum. Theoretical results are illustrated with experiments revealing rich dynamical behaviour, including stochastic bifurcations and synchronization. Applications to sensing are discussed.
{"title":"Non-conservative Levitational Optomechanics: From stochastic bifurcations to synchronization","authors":"V. Svak, O. Brzobohatý, V. Liska, Y. Arita, M. Šiler, P. Jákl, J. Kaňka, SH Simpson, Emily S Wright, G. Bruce, K. Dholakia, P. Zemánek","doi":"10.1364/oma.2023.aw1d.4","DOIUrl":"https://doi.org/10.1364/oma.2023.aw1d.4","url":null,"abstract":"We describe the general stochastic motion of linearly non-conservative optomechanical systems, levitated in vacuum. Theoretical results are illustrated with experiments revealing rich dynamical behaviour, including stochastic bifurcations and synchronization. Applications to sensing are discussed.","PeriodicalId":111173,"journal":{"name":"Biophotonics Congress: Optics in the Life Sciences 2023 (OMA, NTM, BODA, OMP, BRAIN)","volume":"74 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132228932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
We demonstrate a mobile system for large-scale neuron recording with simultaneous deep nucleus stimulation. With the device, cortical-wide Ca2+ activity under vagus nerve stimulation was recorded in freely behaving mice.
{"title":"Large Scale Neuron Recording under Deep Nucleus Stimulation in Freely Behaving Mice","authors":"Lekang Yuan, Yuanlong Zhang, Hanyun Xu, Jiamin Wu, Guihua Xiao, Hao Xie, Qionghai Dai","doi":"10.1364/brain.2023.bm3b.5","DOIUrl":"https://doi.org/10.1364/brain.2023.bm3b.5","url":null,"abstract":"We demonstrate a mobile system for large-scale neuron recording with simultaneous deep nucleus stimulation. With the device, cortical-wide Ca2+ activity under vagus nerve stimulation was recorded in freely behaving mice.","PeriodicalId":111173,"journal":{"name":"Biophotonics Congress: Optics in the Life Sciences 2023 (OMA, NTM, BODA, OMP, BRAIN)","volume":"3 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131874213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.1364/boda.2023.dm4a.5
A. Orlova, K. Akhmedzhanova, A. Kurnikov, D. Khochenkov, Y. Khochenkova, A. Glyavina, I. Turchin, P. Subochev
Differences in the vessel fraction, hemoglobin content and oxygenation level of tumor xenografts are revealed by optoacoustic microscopy and diffuse optical spectroscopy.
利用光声显微镜和漫射光谱学研究异种肿瘤移植血管分数、血红蛋白含量和氧合水平的差异。
{"title":"Comparison of Vascularity and Oxygen State of Experimental Tumors Using Optoacoustic Angiography and Diffuse Optical Spectroscopy","authors":"A. Orlova, K. Akhmedzhanova, A. Kurnikov, D. Khochenkov, Y. Khochenkova, A. Glyavina, I. Turchin, P. Subochev","doi":"10.1364/boda.2023.dm4a.5","DOIUrl":"https://doi.org/10.1364/boda.2023.dm4a.5","url":null,"abstract":"Differences in the vessel fraction, hemoglobin content and oxygenation level of tumor xenografts are revealed by optoacoustic microscopy and diffuse optical spectroscopy.","PeriodicalId":111173,"journal":{"name":"Biophotonics Congress: Optics in the Life Sciences 2023 (OMA, NTM, BODA, OMP, BRAIN)","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132106939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.1364/brain.2023.bw4b.4
C. Nardin, Andrea Sattin, I. Reddy, C. Liberale, Tommaso Fellin
We compensated optical aberrations in 6.4 mm-long and 8.8 mm-long GRIN-based endoscopes using 3D microprinted polymer lenses. Corrected microendoscopes exhibit improved axial resolution and extended field-of-view in two-photon fluorescence imaging experiments.
{"title":"Aberration Correction in Long GRIN-Based Microendoscopes using 3D Printed Polymer Lenses","authors":"C. Nardin, Andrea Sattin, I. Reddy, C. Liberale, Tommaso Fellin","doi":"10.1364/brain.2023.bw4b.4","DOIUrl":"https://doi.org/10.1364/brain.2023.bw4b.4","url":null,"abstract":"We compensated optical aberrations in 6.4 mm-long and 8.8 mm-long GRIN-based endoscopes using 3D microprinted polymer lenses. Corrected microendoscopes exhibit improved axial resolution and extended field-of-view in two-photon fluorescence imaging experiments.","PeriodicalId":111173,"journal":{"name":"Biophotonics Congress: Optics in the Life Sciences 2023 (OMA, NTM, BODA, OMP, BRAIN)","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133867569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
V. Torres, S. Hodge, Rachael Chacko, Joshua J. Levy, L. Vaickus, E. Chen, M. LeBoeuf, K. Samkoe
Fluorescence paired-agent imaging combined with en face margin analysis can detect positive margins in low tumor-bearing (<1% tumor volume) whole tissue samples, as demonstrated in xenograft murine models.
{"title":"Whole-tissue margin evaluation for Mohs surgery using paired-agent imaging","authors":"V. Torres, S. Hodge, Rachael Chacko, Joshua J. Levy, L. Vaickus, E. Chen, M. LeBoeuf, K. Samkoe","doi":"10.1364/omp.2023.om3e.4","DOIUrl":"https://doi.org/10.1364/omp.2023.om3e.4","url":null,"abstract":"Fluorescence paired-agent imaging combined with en face margin analysis can detect positive margins in low tumor-bearing (<1% tumor volume) whole tissue samples, as demonstrated in xenograft murine models.","PeriodicalId":111173,"journal":{"name":"Biophotonics Congress: Optics in the Life Sciences 2023 (OMA, NTM, BODA, OMP, BRAIN)","volume":"282 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134098597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 1900-01-01DOI: 10.1364/oma.2023.atu1d.5
Xuchen Shan, Lei Ding, Shihui Wen, P. Reece, Fan Wang
Nanoscale weak force sensing in aqueous solution is of great interest to researchers from broad areas, including physics and biology. Here we developed a video tracking-based optical tweezers calibration method that enables the detection of the trap stiffness for low refractive index nanoparticles. We found that under resonance conditions, doping lanthanide ions inside a nanocrystal would substantially increase its trap stiffness, achieving a maximum optical trap stiffness of 0.086 pN μm–1 mW–1 for 23.3 nm radius nanoparticles. We further use the dielectric resonance effect to modulate the scattering spectrum of single nanoparticles for multiplexed interferometric scattering microscopy.
{"title":"Lanthanide ion modulated dielectric resonance enhancement for nanoscale optical force dye and interferometric scattering microscopy","authors":"Xuchen Shan, Lei Ding, Shihui Wen, P. Reece, Fan Wang","doi":"10.1364/oma.2023.atu1d.5","DOIUrl":"https://doi.org/10.1364/oma.2023.atu1d.5","url":null,"abstract":"Nanoscale weak force sensing in aqueous solution is of great interest to researchers from broad areas, including physics and biology. Here we developed a video tracking-based optical tweezers calibration method that enables the detection of the trap stiffness for low refractive index nanoparticles. We found that under resonance conditions, doping lanthanide ions inside a nanocrystal would substantially increase its trap stiffness, achieving a maximum optical trap stiffness of 0.086 pN μm–1 mW–1 for 23.3 nm radius nanoparticles. We further use the dielectric resonance effect to modulate the scattering spectrum of single nanoparticles for multiplexed interferometric scattering microscopy.","PeriodicalId":111173,"journal":{"name":"Biophotonics Congress: Optics in the Life Sciences 2023 (OMA, NTM, BODA, OMP, BRAIN)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134100801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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