Advanced Materials最新文献_第2页

Facet-Selective Electrostatic Assembling of 2D Mxene onto Anisotropic Single-Crystal Metal Oxides for Enhanced Photocatalysis 二维Mxene在各向异性单晶金属氧化物上的面选择性静电组装用于增强光催化

IF 29.4 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Advanced Materials

Pub Date : 2026-02-09 DOI: 10.1002/adma.202519087

Shun Kashiwaya, Stephen Nagaraju Myakala, Sho Nekita, Yuta Tsuji, Yuran Niu, Xianjie Liu, Leiqiang Qin, Manisha Sharma, Alexei Zakharov, Lars Hultman, Dominik Eder, Hikaru Saito, Alexey Cherevan, Johanna Rosen

Designing composite photocatalytic systems with nanoscale precision is crucial. While conventional facet-selective photo-deposition successfully utilizes spherical co-catalysts, the directed deposition of pre-synthesized two-dimensional (2D) materials onto specific facets remains extremely challenging. This work demonstrates an electrostatic assembly strategy for the precise deposition of 2D transition metal carbides (MXenes) onto anisotropic single-crystal semiconducting metal oxides. By precisely controlling the solution pH, we modulated the surface charge of the MXenes and the distinct crystallographic facets of the metal oxides, enabling selective deposition driven by electrostatic attraction. Negatively charged Mo_4/3C MXenes were selectively deposited on the electron-rich (101) surface of TiO₂ at pH 3, the (100) surface of Cu₂O exposed at pH 11, and the (010) surface of BiVO₄ at pH 1.5. The high facet selectivity was confirmed through a combination of advanced techniques, including electron microscopy, electron spectroscopy, and synchrotron-based spectromicroscopy. This selective interfacial engineering promotes spatially separated charge carrier migration toward distinct facets, while Schottky barriers form at the MXenes/oxides interfaces. The MXenes act as efficient reduction co-catalysts, facilitating the rapid consumption of electrons, thereby enhancing photocatalytic hydrogen evolution. This work establishes a generalizable, non-photolytic method for integrating challenging 2D co-catalysts with facet-engineered semiconductors for designing composite photocatalysts.

设计纳米级精度的复合光催化系统至关重要。虽然传统的面选择性光沉积技术成功地利用了球形共催化剂，但将预先合成的二维（2D）材料定向沉积到特定的面上仍然极具挑战性。这项工作展示了一种静电组装策略，用于在各向异性单晶半导体金属氧化物上精确沉积二维过渡金属碳化物（MXenes）。通过精确控制溶液的pH值，我们调节了MXenes的表面电荷和金属氧化物的不同晶体学方面，使静电吸引驱动的选择性沉积成为可能。带负电荷的Mo4/3C MXenes选择性沉积在pH为3时富电子的TiO2（101）表面、pH为11时暴露的Cu2O（100）表面和pH为1.5时暴露的BiVO4（010）表面。通过结合先进技术，包括电子显微镜、电子能谱和基于同步加速器的光谱显微镜，证实了高面选择性。这种选择性界面工程促进了空间分离的载流子向不同面的迁移，同时在MXenes/氧化物界面形成肖特基势垒。MXenes作为高效的还原共催化剂，促进电子的快速消耗，从而增强光催化析氢。这项工作建立了一种可推广的非光解方法，将具有挑战性的2D共催化剂与面工程半导体集成在一起，用于设计复合光催化剂。

{"title":"Facet-Selective Electrostatic Assembling of 2D Mxene onto Anisotropic Single-Crystal Metal Oxides for Enhanced Photocatalysis","authors":"Shun Kashiwaya, Stephen Nagaraju Myakala, Sho Nekita, Yuta Tsuji, Yuran Niu, Xianjie Liu, Leiqiang Qin, Manisha Sharma, Alexei Zakharov, Lars Hultman, Dominik Eder, Hikaru Saito, Alexey Cherevan, Johanna Rosen","doi":"10.1002/adma.202519087","DOIUrl":"https://doi.org/10.1002/adma.202519087","url":null,"abstract":"Designing composite photocatalytic systems with nanoscale precision is crucial. While conventional facet-selective photo-deposition successfully utilizes spherical co-catalysts, the directed deposition of pre-synthesized two-dimensional (2D) materials onto specific facets remains extremely challenging. This work demonstrates an electrostatic assembly strategy for the precise deposition of 2D transition metal carbides (MXenes) onto anisotropic single-crystal semiconducting metal oxides. By precisely controlling the solution pH, we modulated the surface charge of the MXenes and the distinct crystallographic facets of the metal oxides, enabling selective deposition driven by electrostatic attraction. Negatively charged Mo4/3C MXenes were selectively deposited on the electron-rich (101) surface of TiO2 at pH 3, the (100) surface of Cu2O exposed at pH 11, and the (010) surface of BiVO4 at pH 1.5. The high facet selectivity was confirmed through a combination of advanced techniques, including electron microscopy, electron spectroscopy, and synchrotron-based spectromicroscopy. This selective interfacial engineering promotes spatially separated charge carrier migration toward distinct facets, while Schottky barriers form at the MXenes/oxides interfaces. The MXenes act as efficient reduction co-catalysts, facilitating the rapid consumption of electrons, thereby enhancing photocatalytic hydrogen evolution. This work establishes a generalizable, non-photolytic method for integrating challenging 2D co-catalysts with facet-engineered semiconductors for designing composite photocatalysts.","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"18 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146139090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bulk Passivation of Molybdenum Trioxide Enables Inverted Organic Photovoltaics with Significantly Enhanced Stability under Extreme Conditions 三氧化钼的体钝化使倒置有机光伏电池在极端条件下具有显著增强的稳定性

IF 29.4 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Advanced Materials

Pub Date : 2026-02-09 DOI: 10.1002/adma.202522299

Qianqian Qi, Jiaming Huang, Cenqi Yan, Jiayu Wang, Jiehao Fu, Kaifeng Jing, Guang Yang, Yakun He, Yufei Gong, Jie Lv, Xiaokang Sun, Xian He, Qiang Yang, Xiancheng Ren, Ke Zeng, Hanlin Hu, Hua Tang, Frédéric Laquai, Lei Meng, Yongfang Li, Gang Li, Pei Cheng

While organic photovoltaics (OPVs) have achieved remarkable efficiencies, their practical deployment remains hindered by insufficient stability. Herein, we find that degradation is strongly associated with diffusion-driven intermixing and redox chemistry at the buried molybdenum trioxide (MoO₃)/photoactive materials contact region. To address this issue, we incorporate 1H-isoindole-1,3(2H)-dione, 2,2’-(oxydi-4,1-phenylene) bis[3a,4,7,7a-tetrahydro-(9CI)] (IPE) into the bulk heterojunction as a bulk passivator that interacts with diffusing MoO₃ species by passivating oxygen vacancies in MoO₃, thereby suppressing redox reactions between MoO₃ and photoactive materials. The IPE-containing devices achieve a champion efficiency of 19.06% alongside exceptional thermal robustness, retaining 87.5% of their initial efficiency after thermal aging at 170°C for 5 h (vs. 48.8% for control devices). Critically, under harsh environmental stressors, these devices maintain >80% of their initial efficiency after 500 thermal cycles (−40°C to 85°C, ∼60% relative humidity, ISOS-T-3) and over 1150-h continuous maximum power point tracking under 1 Sun illumination (65°C, ∼50% relative humidity, ISOS-L-3). This represents one of the highest stability levels reported for OPVs under the stringent ISOS-T-3 and ISOS-L-3 protocols. This work provides a generalizable bulk modification strategy to mitigate diffusion- and redox-driven degradation at buried contacts, paving the way for the practical deployment of stable, high-efficiency OPVs.

虽然有机光伏发电（opv）已经取得了显著的效率，但其实际部署仍然受到稳定性不足的阻碍。在此，我们发现降解与埋藏的三氧化钼(MoO3)/光活性材料接触区域的扩散驱动混合和氧化还原化学密切相关。为了解决这一问题，我们将1h -异吲哚-1,3(2H)-二酮，2,2 ' -（氧-4,1-苯基）双[3a，4,7,7a-四氢-(9CI)] （IPE）加入到本体异质结中，作为本体钝化剂，通过钝化MoO3中的氧空位与扩散的MoO3相互作用，从而抑制MoO3与光活性材料之间的氧化还原反应。含有ipe的器件具有19.06%的冠军效率以及出色的热鲁棒性，在170°C热老化5小时后保持其初始效率的87.5%（相比之下，控制器件为48.8%）。至关重要的是，在恶劣的环境压力下，这些设备在500个热循环（- 40°C至85°C，相对湿度为60%，iso - t -3）和在1个太阳照射（65°C，相对湿度为50%，iso - l -3）下超过1150小时的连续最大功率点跟踪后保持80%的初始效率。这是在严格的iso - t -3和iso - l -3协议下报道的opv的最高稳定性水平之一。这项工作提供了一种通用的整体改性策略，以减轻埋藏触点处的扩散和氧化还原驱动的降解，为稳定、高效的opv的实际部署铺平了道路。

{"title":"Bulk Passivation of Molybdenum Trioxide Enables Inverted Organic Photovoltaics with Significantly Enhanced Stability under Extreme Conditions","authors":"Qianqian Qi, Jiaming Huang, Cenqi Yan, Jiayu Wang, Jiehao Fu, Kaifeng Jing, Guang Yang, Yakun He, Yufei Gong, Jie Lv, Xiaokang Sun, Xian He, Qiang Yang, Xiancheng Ren, Ke Zeng, Hanlin Hu, Hua Tang, Frédéric Laquai, Lei Meng, Yongfang Li, Gang Li, Pei Cheng","doi":"10.1002/adma.202522299","DOIUrl":"https://doi.org/10.1002/adma.202522299","url":null,"abstract":"While organic photovoltaics (OPVs) have achieved remarkable efficiencies, their practical deployment remains hindered by insufficient stability. Herein, we find that degradation is strongly associated with diffusion-driven intermixing and redox chemistry at the buried molybdenum trioxide (MoO3)/photoactive materials contact region. To address this issue, we incorporate 1H-isoindole-1,3(2H)-dione, 2,2’-(oxydi-4,1-phenylene) bis[3a,4,7,7a-tetrahydro-(9CI)] (IPE) into the bulk heterojunction as a bulk passivator that interacts with diffusing MoO3 species by passivating oxygen vacancies in MoO3, thereby suppressing redox reactions between MoO3 and photoactive materials. The IPE-containing devices achieve a champion efficiency of 19.06% alongside exceptional thermal robustness, retaining 87.5% of their initial efficiency after thermal aging at 170°C for 5 h (vs. 48.8% for control devices). Critically, under harsh environmental stressors, these devices maintain >80% of their initial efficiency after 500 thermal cycles (−40°C to 85°C, ∼60% relative humidity, ISOS-T-3) and over 1150-h continuous maximum power point tracking under 1 Sun illumination (65°C, ∼50% relative humidity, ISOS-L-3). This represents one of the highest stability levels reported for OPVs under the stringent ISOS-T-3 and ISOS-L-3 protocols. This work provides a generalizable bulk modification strategy to mitigate diffusion- and redox-driven degradation at buried contacts, paving the way for the practical deployment of stable, high-efficiency OPVs.","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"46 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146146374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Construction of Quinazoline-Bridged Donor-Acceptor Covalent Organic Frameworks for Photocatalytic Sulfoxide Synthesis from Alkenes and Thiols 烯、硫醇光催化合成亚砜用喹唑啉桥接供受体共价有机框架的构建

IF 29.4 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Advanced Materials

Pub Date : 2026-02-09 DOI: 10.1002/adma.202523654

Xiaohu Li, Yanjing Wang, Liang Cheng, Li Liu

As an emerging class of crystalline porous materials, COFs have attracted increasing attention in fields such as photocatalysis. Understanding how the linkage chemistry of COFs influences their construction and photoelectrochemical properties and photocatalytic performance remains a significant challenge. Herein, two quinazoline-linked COFs are assembled by the condensation of 1,3,6,8-tetra (4-formylphenyl) pyrene (TFPPy) with 3,3'-dibenzoyl-[1,1'-biphenyl]-4,4'-diamine (BD(Bz)) and 3,3'-dibenzoyl-4,4'-terphenyl diamine (BT(Bz)) respectively through a three-component reaction in the presence of an ammonia source. By integrating quinazoline linkage with pyrene structural unit, BD(Bz)-TFPPy-COF (COF-1b) and BT(Bz)-TFPPy-COF (COF-2b) exhibit electron donor-acceptor properties and possess high chemical stability as well, which demonstrated excellent photocatalytic performance for the selective synthesis of sulfoxides from alkenes and thiols. Incorporation of linkage chemistry and building blocks selection of COFs provides effective strategies for modulating its optoelectronic properties to improve photocatalytic performance.

COFs作为一类新兴的晶体多孔材料，在光催化等领域受到越来越多的关注。了解COFs的连锁化学如何影响其结构、光电化学性质和光催化性能仍然是一个重大挑战。本文在氨源存在的情况下，通过三组分反应分别将1,3,6,8-四（4-甲苯基苯基）芘（TFPPy）与3,3'-二苯甲酰-[1,1'-联苯]-4,4'-三苯二胺（BD(Bz)）和3,3'-二苯甲酰-4,4'-三苯二胺（BT(Bz)）缩合成两个喹唑啉连接的COFs。BD(Bz)-TFPPy-COF （COF-1b）和BT(Bz)-TFPPy-COF （COF-2b）通过整合喹唑啉键和芘结构单元，表现出电子给受体性质和较高的化学稳定性，在烯烃和硫醇选择性合成亚砜方面表现出优异的光催化性能。结合链接化学和构建块选择的COFs提供了有效的策略来调节其光电性能，以提高光催化性能。

{"title":"Construction of Quinazoline-Bridged Donor-Acceptor Covalent Organic Frameworks for Photocatalytic Sulfoxide Synthesis from Alkenes and Thiols","authors":"Xiaohu Li, Yanjing Wang, Liang Cheng, Li Liu","doi":"10.1002/adma.202523654","DOIUrl":"https://doi.org/10.1002/adma.202523654","url":null,"abstract":"As an emerging class of crystalline porous materials, COFs have attracted increasing attention in fields such as photocatalysis. Understanding how the linkage chemistry of COFs influences their construction and photoelectrochemical properties and photocatalytic performance remains a significant challenge. Herein, two quinazoline-linked COFs are assembled by the condensation of 1,3,6,8-tetra (4-formylphenyl) pyrene (TFPPy) with 3,3'-dibenzoyl-[1,1'-biphenyl]-4,4'-diamine (BD(Bz)) and 3,3'-dibenzoyl-4,4'-terphenyl diamine (BT(Bz)) respectively through a three-component reaction in the presence of an ammonia source. By integrating quinazoline linkage with pyrene structural unit, BD(Bz)-TFPPy-COF (COF-1b) and BT(Bz)-TFPPy-COF (COF-2b) exhibit electron donor-acceptor properties and possess high chemical stability as well, which demonstrated excellent photocatalytic performance for the selective synthesis of sulfoxides from alkenes and thiols. Incorporation of linkage chemistry and building blocks selection of COFs provides effective strategies for modulating its optoelectronic properties to improve photocatalytic performance.","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"39 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146146375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structural Modulation Enables Bright and Efficient Cs–Cu–Cl Electroluminescence 结构调制实现明亮高效的Cs-Cu-Cl电致发光

IF 29.4 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Advanced Materials

Pub Date : 2026-02-09 DOI: 10.1002/adma.202522256

Yongqiang Ji, Yuquan Wang, Zexing Yuan, Yufan Zhou, Poen Hsueh, Zhiqiang Chen, Yue Zhang, Hailong Wang, Qingqian Wang, Zhenwei Li, Peng Chen, Xiaobo He, Xinpeng Wang, Jiang Wu, Yi Tong, Xiaoyu Yang, Rui Zhu, Xinqiang Wang

Cesium–copper–halide (Cs–Cu–X) perovskites are potential substitutes to lead-halide perovskites for broadband electroluminescence (EL) in white light-emitting diodes (LED) due to their non-toxicity and unique self-trapped exciton (STE) characters. Many efforts have been devoted to pushing up EL efficiencies of Cs–Cu–I LED devices, while there is no report of EL based on their Cl-based counterparts yet. In this work, the EL of the Cs–Cu–Cl nanocrystals (NCs) was first demonstrated by a holistic structural modulation, whose champion device reached an external quantum efficiency of 2.02% and a high luminance of 3345 cd m⁻². The efficient bluish-white EL was explored to collectively derive from the smooth film morphology, exciton inter-band transition, triplet STE behavior, and promising electron transport ability of the Cs–Cu–Cl NC film. Additionally, the potential photophysical process for the broadband emission was proposed, collectively expanding the Cu-based perovskite EL family for displays and lighting applications.

铯-铜-卤化（Cs-Cu-X）钙钛矿由于其无毒和独特的自捕获激子（STE）特性，是替代卤化铅钙钛矿用于白光二极管（LED）宽带电致发光（EL）的潜在替代品。许多人致力于提高Cs-Cu-I LED器件的EL效率，而基于cl - i LED器件的EL还没有报道。本文首次通过整体结构调制证明了Cs-Cu-Cl纳米晶体（nc）的EL，其champion器件达到了2.02%的外量子效率和3345 cd m−2的高亮度。有效的蓝白色电致发光是由Cs-Cu-Cl NC膜的光滑膜形态、激子带间跃迁、三重态电致发光行为和有前途的电子传输能力共同产生的。此外，还提出了宽带发射的潜在光物理过程，共同扩展了用于显示和照明应用的cu基钙钛矿EL家族。

{"title":"Structural Modulation Enables Bright and Efficient Cs–Cu–Cl Electroluminescence","authors":"Yongqiang Ji, Yuquan Wang, Zexing Yuan, Yufan Zhou, Poen Hsueh, Zhiqiang Chen, Yue Zhang, Hailong Wang, Qingqian Wang, Zhenwei Li, Peng Chen, Xiaobo He, Xinpeng Wang, Jiang Wu, Yi Tong, Xiaoyu Yang, Rui Zhu, Xinqiang Wang","doi":"10.1002/adma.202522256","DOIUrl":"https://doi.org/10.1002/adma.202522256","url":null,"abstract":"Cesium–copper–halide (Cs–Cu–X) perovskites are potential substitutes to lead-halide perovskites for broadband electroluminescence (EL) in white light-emitting diodes (LED) due to their non-toxicity and unique self-trapped exciton (STE) characters. Many efforts have been devoted to pushing up EL efficiencies of Cs–Cu–I LED devices, while there is no report of EL based on their Cl-based counterparts yet. In this work, the EL of the Cs–Cu–Cl nanocrystals (NCs) was first demonstrated by a holistic structural modulation, whose champion device reached an external quantum efficiency of 2.02% and a high luminance of 3345 cd m−2. The efficient bluish-white EL was explored to collectively derive from the smooth film morphology, exciton inter-band transition, triplet STE behavior, and promising electron transport ability of the Cs–Cu–Cl NC film. Additionally, the potential photophysical process for the broadband emission was proposed, collectively expanding the Cu-based perovskite EL family for displays and lighting applications.","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"1 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146146378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A 3D-Printed Piezoelectric Scaffold With Bio-Inspired Gradient and Dynamic Adaptation for Tendon Regeneration. 具有仿生梯度和动态自适应的3d打印肌腱再生压电支架。

IF 26.8 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Advanced Materials

Pub Date : 2026-02-09 DOI: 10.1002/adma.202517298

Xinyue Huang, Jiachen Liang, Qing Jia, Kaiqi Qin, Jiakai Shi, Zengjie Fan

Tendon regeneration requires materials that dynamically adapt to the healing stages, offering mechanical support, adhesion prevention, inflammation control, and collagen remodeling. We introduce a novel, dynamically adaptive piezoelectric hydrogel designed to address these requirements. The hydrogel features a bioinspired, anti-adhesive lotus structure to minimize fibroblast and protein adhesion, preventing postoperative complications. Furthermore, it incorporates rationally designed gradients in piezoelectricity, mechanical properties, and degradation rate. These gradients allow the hydrogel to dynamically match the evolving needs of tendon healing, providing adjustable mechanical, electrical stimulation, and controllable degradation. The hydrogel demonstrably reduces inflammation (downregulating TNF-α), promotes M2 macrophage polarization, inhibits bacterial growth, and stimulates endogenous tendon regeneration. This regeneration is characterized by increased collagen I deposition, improved fiber alignment, and enhanced biomechanical properties. Transcriptomic analysis revealed upregulation of genes associated with mechanotransduction, tissue remodeling, and anti-inflammatory responses, alongside downregulation of fibrotic and oxidative stress pathways. This self-powered, multi-gradient scaffold represents a significant advancement in tendon tissue engineering, offering a promising strategy for tendinopathy treatment.

肌腱再生需要动态适应愈合阶段的材料，提供机械支持、预防粘连、炎症控制和胶原蛋白重塑。我们介绍了一种新颖的、动态自适应的压电水凝胶，旨在满足这些要求。这种水凝胶具有生物启发的抗粘连莲花结构，可以最大限度地减少成纤维细胞和蛋白质的粘连，防止术后并发症。此外，它还包含了合理设计的压电性、力学性能和降解率梯度。这些梯度允许水凝胶动态匹配肌腱愈合的不断变化的需求，提供可调节的机械、电刺激和可控的降解。水凝胶可明显减轻炎症（下调TNF-α），促进M2巨噬细胞极化，抑制细菌生长，刺激内源性肌腱再生。这种再生的特点是胶原I沉积增加，纤维排列改善，生物力学性能增强。转录组学分析显示，与机械转导、组织重塑和抗炎反应相关的基因上调，以及纤维化和氧化应激途径的下调。这种自供电的多梯度支架代表了肌腱组织工程的重大进步，为肌腱病变的治疗提供了一种有前途的策略。

{"title":"A 3D-Printed Piezoelectric Scaffold With Bio-Inspired Gradient and Dynamic Adaptation for Tendon Regeneration.","authors":"Xinyue Huang, Jiachen Liang, Qing Jia, Kaiqi Qin, Jiakai Shi, Zengjie Fan","doi":"10.1002/adma.202517298","DOIUrl":"https://doi.org/10.1002/adma.202517298","url":null,"abstract":"Tendon regeneration requires materials that dynamically adapt to the healing stages, offering mechanical support, adhesion prevention, inflammation control, and collagen remodeling. We introduce a novel, dynamically adaptive piezoelectric hydrogel designed to address these requirements. The hydrogel features a bioinspired, anti-adhesive lotus structure to minimize fibroblast and protein adhesion, preventing postoperative complications. Furthermore, it incorporates rationally designed gradients in piezoelectricity, mechanical properties, and degradation rate. These gradients allow the hydrogel to dynamically match the evolving needs of tendon healing, providing adjustable mechanical, electrical stimulation, and controllable degradation. The hydrogel demonstrably reduces inflammation (downregulating TNF-α), promotes M2 macrophage polarization, inhibits bacterial growth, and stimulates endogenous tendon regeneration. This regeneration is characterized by increased collagen I deposition, improved fiber alignment, and enhanced biomechanical properties. Transcriptomic analysis revealed upregulation of genes associated with mechanotransduction, tissue remodeling, and anti-inflammatory responses, alongside downregulation of fibrotic and oxidative stress pathways. This self-powered, multi-gradient scaffold represents a significant advancement in tendon tissue engineering, offering a promising strategy for tendinopathy treatment.","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":" ","pages":"e17298"},"PeriodicalIF":26.8,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146140315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Strain-Tunable Thermal Conductivity in Largely Amorphous Polyolefin Fibers via Alignment-Induced Vibrational Delocalization. 非晶态聚烯烃纤维的应变可调热导率研究。

IF 26.8 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Advanced Materials

Pub Date : 2026-02-09 DOI: 10.1002/adma.202520371

Duo Xu, Buxuan Li, You Lyu, Vivian J Santamaria-Garcia, Yuan Zhu, Svetlana V Boriskina

Developing fast, reversible, and recyclable thermal switches is essential to advance adaptive thermal management. Here, we present a strain-tunable thermal switch based on largely amorphous olefin block copolymer (OBC) fibers, achieving a continuous switching ratio above 2 over 1000 cycles, as well as very short response times below 0.22 s. Using Raman spectroscopy, we quantify vibrational delocalization with increasing strain and demonstrate its direct connection to the observed thermal conductivity changes. We show that unlike prior assumptions linking propagating heat carriers primarily to crystalline domains, alignment in amorphous systems can enable phonon-like modes that dominate transport. To our best knowledge, this work is the first to experimentally probe vibrational delocalization using Raman spectroscopy and to demonstrate that alignment alone can govern the dominant carrier in disordered polymers. These findings establish design strategies for fatigue-resistant, high-performance, and recyclable polymer thermal switches for advanced thermal energy transport applications.

开发快速、可逆和可回收的热开关对于推进自适应热管理至关重要。在这里，我们提出了一种基于非晶烯烃嵌段共聚物（OBC）纤维的应变可调热开关，在1000次循环中实现了超过2的连续开关比，以及低于0.22 s的极短响应时间。利用拉曼光谱，我们量化了随应变增加的振动离域，并证明了它与观察到的热导率变化的直接联系。我们表明，与先前的假设不同，将传播的热载体主要与晶体域联系起来，非晶系统中的对齐可以使主导传输的声子模式成为可能。据我们所知，这项工作是第一次利用拉曼光谱实验探测振动离域，并证明了排列本身可以控制无序聚合物中的主导载流子。这些发现建立了用于先进热能传输应用的抗疲劳、高性能和可回收聚合物热开关的设计策略。

{"title":"Strain-Tunable Thermal Conductivity in Largely Amorphous Polyolefin Fibers via Alignment-Induced Vibrational Delocalization.","authors":"Duo Xu, Buxuan Li, You Lyu, Vivian J Santamaria-Garcia, Yuan Zhu, Svetlana V Boriskina","doi":"10.1002/adma.202520371","DOIUrl":"https://doi.org/10.1002/adma.202520371","url":null,"abstract":"Developing fast, reversible, and recyclable thermal switches is essential to advance adaptive thermal management. Here, we present a strain-tunable thermal switch based on largely amorphous olefin block copolymer (OBC) fibers, achieving a continuous switching ratio above 2 over 1000 cycles, as well as very short response times below 0.22 s. Using Raman spectroscopy, we quantify vibrational delocalization with increasing strain and demonstrate its direct connection to the observed thermal conductivity changes. We show that unlike prior assumptions linking propagating heat carriers primarily to crystalline domains, alignment in amorphous systems can enable phonon-like modes that dominate transport. To our best knowledge, this work is the first to experimentally probe vibrational delocalization using Raman spectroscopy and to demonstrate that alignment alone can govern the dominant carrier in disordered polymers. These findings establish design strategies for fatigue-resistant, high-performance, and recyclable polymer thermal switches for advanced thermal energy transport applications.","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":" ","pages":"e20371"},"PeriodicalIF":26.8,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146140349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Falcon Vision-Inspired Ultrafast Traffic Obstacle Avoidance Based on 2D Edge-Rich van de Waals Heterostructures 基于二维富边van de Waals异质结构的猎鹰视觉超快速交通避障

IF 29.4 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Advanced Materials

Pub Date : 2026-02-09 DOI: 10.1002/adma.202512548

Yang Guo, Shenghong Liu, Tao Hu, Xiang Lin, Lintao Du, Zhuo Diao, Gaohang Huo, Decai Ouyang, Wei Si, Zhen Cui, Huiqiao Li, Yuan Li, Tianyou Zhai

Ultrafast and reliable visual perception is essential for obstacle avoidance in autonomous driving, where split-second decisions must be made in complex, high-speed environments, yet remains constrained by the limited temporal resolution and processing latency of conventional devices. Here, inspired by the exceptional temporal resolution of falcon vision systems (>150 Hz), we develop a neuromorphic vision sensor capable of ultrafast, edge-selective perception for dynamic traffic scenarios. The sensor leverages vertically stacked, edge-rich SnS₂/MoS₂ van der Waals heterostructures, in which a high density of atomic-scale interfaces and defective edges enables enhanced light-matter interactions and rapid carrier dynamics. These structural advantages endow the Falcon Vision Sensor (FVS) with synaptic plasticity (PPF = 201%, LTP = 1300s), high refresh rate (250 Hz), and intrinsic erasure behaviors, closely mimicking the temporal precision and motion discrimination features of falcon vision. When the synaptic devices are integrated with computing modules, the system achieves real-time obstacle detection, along with a directional motion recognition accuracy of 98.89%. This work demonstrates a robust biologically inspired visual intelligence, offering a compact, low-latency solution for next-generation autonomous vehicles and edge AI applications requiring rapid environmental responsiveness.

超快速和可靠的视觉感知对于自动驾驶中的避障至关重要，因为自动驾驶必须在复杂的高速环境中瞬间做出决策，但仍然受到传统设备有限的时间分辨率和处理延迟的限制。在这里，受猎鹰视觉系统卓越的时间分辨率（150 Hz）的启发，我们开发了一种神经形态视觉传感器，能够为动态交通场景提供超快，边缘选择性感知。该传感器利用垂直堆叠，富边的SnS2/MoS2范德华异质结构，其中高密度的原子尺度界面和缺陷边缘能够增强光-物质相互作用和快速载流子动力学。这些结构优势赋予了猎鹰视觉传感器（Falcon Vision Sensor， FVS）突触可塑性（PPF = 201%, LTP = 1300s）、高刷新率（250 Hz）和固有擦除行为，与猎鹰视觉的时间精度和运动识别特性非常相似。当突触装置与计算模块集成时，系统实现了实时障碍物检测，方向运动识别准确率达到98.89%。这项工作展示了一种强大的受生物启发的视觉智能，为需要快速环境响应的下一代自动驾驶汽车和边缘人工智能应用提供了紧凑、低延迟的解决方案。

{"title":"Falcon Vision-Inspired Ultrafast Traffic Obstacle Avoidance Based on 2D Edge-Rich van de Waals Heterostructures","authors":"Yang Guo, Shenghong Liu, Tao Hu, Xiang Lin, Lintao Du, Zhuo Diao, Gaohang Huo, Decai Ouyang, Wei Si, Zhen Cui, Huiqiao Li, Yuan Li, Tianyou Zhai","doi":"10.1002/adma.202512548","DOIUrl":"https://doi.org/10.1002/adma.202512548","url":null,"abstract":"Ultrafast and reliable visual perception is essential for obstacle avoidance in autonomous driving, where split-second decisions must be made in complex, high-speed environments, yet remains constrained by the limited temporal resolution and processing latency of conventional devices. Here, inspired by the exceptional temporal resolution of falcon vision systems (>150 Hz), we develop a neuromorphic vision sensor capable of ultrafast, edge-selective perception for dynamic traffic scenarios. The sensor leverages vertically stacked, edge-rich SnS2/MoS2 van der Waals heterostructures, in which a high density of atomic-scale interfaces and defective edges enables enhanced light-matter interactions and rapid carrier dynamics. These structural advantages endow the Falcon Vision Sensor (FVS) with synaptic plasticity (PPF = 201%, LTP = 1300s), high refresh rate (250 Hz), and intrinsic erasure behaviors, closely mimicking the temporal precision and motion discrimination features of falcon vision. When the synaptic devices are integrated with computing modules, the system achieves real-time obstacle detection, along with a directional motion recognition accuracy of 98.89%. This work demonstrates a robust biologically inspired visual intelligence, offering a compact, low-latency solution for next-generation autonomous vehicles and edge AI applications requiring rapid environmental responsiveness.","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"5 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146139025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Biomimetic Urethra-on-a-Chip Platform for Modelling Fibrosis: 3D-Printing and Near-Field Electrospinning in BAM-Functionalized Microenvironment 模拟纤维化的仿生尿道芯片平台：在bam功能化微环境中3d打印和近场静电纺丝

IF 29.4 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Advanced Materials

Pub Date : 2026-02-09 DOI: 10.1002/adma.202521431

Jiafu Liu, Wenzhuo Fang, Kai Wang, Zhidong Ma, Jie Yan, Ming Yang, Yangwang Jin, Meng Liu, Xi Yang, Wenyao Li, Qiang Fu, Yaopeng Zhang, Kaile Zhang

Urethral stricture, a prevalent urological disorder characterized by fibrosis of periurethral tissues, severely compromises urinary function and patient quality of life. Despite various clinical interventions, recurrence remains frequent, largely due to the lack of physiologically relevant in vitro models for mechanistic investigation and drug screening. Here, we present a biomimetic urethra-on-a-chip platform that integrates microfluidics, three-dimensional (3D) printing, and near-field electrospinning to recapitulate the structural and biochemical complexity of the native urethra. The device features polydimethylsiloxane (PDMS) microchannels coupled with a multilayered polycaprolactone (PCL) membrane, functionalized using a bladder acellular matrix (BAM)–gelatin bioink to emulate the extracellular matrix (ECM) microenvironment. A bilayer microchamber configuration supports spatially organized coculture of fibroblasts and urothelial cells under dynamic perfusion, reproducing physiological shear stress and nutrient gradients. Under fibrotic stimulation by transforming growth factor beta 1 (TGF-β1), the system faithfully mimicked fibroblast activation and epithelial injury, while rapamycin treatment effectively attenuated fibrotic responses, validating its potential for pharmacological testing. This urethra-on-a-chip provides a robust, reproducible, and cost-efficient platform for modeling urethral fibrosis and evaluating antifibrotic therapeutics. By bridging biofabrication, microfluidics, and tissue pathophysiology, this work establishes a versatile organ-on-a-chip model with significant implications for translational research and personalized regenerative medicine.

尿道狭窄是一种常见的泌尿系统疾病，以尿道周围组织纤维化为特征，严重影响泌尿功能和患者的生活质量。尽管有各种临床干预措施，复发仍然频繁，主要是由于缺乏生理相关的体外模型来进行机制研究和药物筛选。在这里，我们提出了一个集成了微流体、三维（3D）打印和近场静电纺丝的仿生尿道芯片平台，以概括天然尿道的结构和生化复杂性。该装置的特点是聚二甲基硅氧烷（PDMS）微通道与多层聚己内酯（PCL）膜耦合，使用膀胱脱细胞基质(BAM) -明胶生物链接进行功能化，以模拟细胞外基质（ECM）微环境。双层微室结构支持成纤维细胞和尿路上皮细胞在动态灌注下的空间组织共培养，再现生理剪切应力和营养梯度。在转化生长因子β1 （TGF-β1）的纤维化刺激下，该系统忠实地模拟成纤维细胞激活和上皮损伤，而雷帕霉素治疗有效地减弱了纤维化反应，验证了其药理学测试的潜力。这种尿道芯片为模拟尿道纤维化和评估抗纤维化治疗提供了一个强大的、可重复的、经济高效的平台。通过连接生物制造、微流体学和组织病理生理学，这项工作建立了一个多功能器官芯片模型，对转化研究和个性化再生医学具有重要意义。

{"title":"Biomimetic Urethra-on-a-Chip Platform for Modelling Fibrosis: 3D-Printing and Near-Field Electrospinning in BAM-Functionalized Microenvironment","authors":"Jiafu Liu, Wenzhuo Fang, Kai Wang, Zhidong Ma, Jie Yan, Ming Yang, Yangwang Jin, Meng Liu, Xi Yang, Wenyao Li, Qiang Fu, Yaopeng Zhang, Kaile Zhang","doi":"10.1002/adma.202521431","DOIUrl":"https://doi.org/10.1002/adma.202521431","url":null,"abstract":"Urethral stricture, a prevalent urological disorder characterized by fibrosis of periurethral tissues, severely compromises urinary function and patient quality of life. Despite various clinical interventions, recurrence remains frequent, largely due to the lack of physiologically relevant in vitro models for mechanistic investigation and drug screening. Here, we present a biomimetic urethra-on-a-chip platform that integrates microfluidics, three-dimensional (3D) printing, and near-field electrospinning to recapitulate the structural and biochemical complexity of the native urethra. The device features polydimethylsiloxane (PDMS) microchannels coupled with a multilayered polycaprolactone (PCL) membrane, functionalized using a bladder acellular matrix (BAM)–gelatin bioink to emulate the extracellular matrix (ECM) microenvironment. A bilayer microchamber configuration supports spatially organized coculture of fibroblasts and urothelial cells under dynamic perfusion, reproducing physiological shear stress and nutrient gradients. Under fibrotic stimulation by transforming growth factor beta 1 (TGF-β1), the system faithfully mimicked fibroblast activation and epithelial injury, while rapamycin treatment effectively attenuated fibrotic responses, validating its potential for pharmacological testing. This urethra-on-a-chip provides a robust, reproducible, and cost-efficient platform for modeling urethral fibrosis and evaluating antifibrotic therapeutics. By bridging biofabrication, microfluidics, and tissue pathophysiology, this work establishes a versatile organ-on-a-chip model with significant implications for translational research and personalized regenerative medicine.","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"16 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146146377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultrafast Programming of Large Curvature Based on Selenium-Sulfur Dynamic Metathesis 基于硒-硫动态分解的大曲率超快规划

IF 29.4 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Advanced Materials

Pub Date : 2026-02-08 DOI: 10.1002/adma.202523642

Ruiyang Wen, Chenglin Zhang, Chaozheng Miao, Wanting Huang, Rui Quan, Ruohan Huang, Han Wu, Zehuan Huang, Yizheng Tan, Huaping Xu

The construction and integration of curvature govern the structure and function of materials based on 2D sheets, yet achieving ultrafast and scalable curvature programming remains a major challenge. We rapidly generate large stress mismatches by combining an ultrafast stress-relaxing diselenide-containing polyurethane with an ultraslow stress-relaxing disulfide-containing polyurethane. Coupled with modular components and compression, this mismatch enables localized, directional loading of high stress with excellent scalability. Using this strategy, 2D polymer sheets achieve 180° bending within 10 s of UV irradiation, yielding a curvature-programming rate 15-fold faster than state-of-the-art methods. Furthermore, origami modules, which display a 37-fold enhancement in compressive performance, can be obtained through mass production and assembled into complex 3D architectures. This rapid, high-curvature programming approach offers efficiency, mechanical robustness, and scalability, advancing the practical deployment of origami-based metamaterials.

曲率的构造和集成决定着基于二维薄片的材料的结构和功能，但实现超快速和可扩展的曲率规划仍然是一个主要挑战。我们通过将一种超快速应力松弛的含二硫化物的聚氨酯与一种超低应力松弛的含二硫化物的聚氨酯相结合，迅速产生了大的应力不匹配。再加上模块化组件和压缩，这种不匹配可以实现高应力的局部定向加载，具有出色的可扩展性。使用这种策略，二维聚合物片材在紫外线照射10秒内实现180°弯曲，曲率规划速度比目前最先进的方法快15倍。此外，折纸模块的压缩性能提高了37倍，可以通过批量生产和组装成复杂的3D结构。这种快速、高曲率的编程方法提供了效率、机械稳健性和可扩展性，推进了折纸超材料的实际部署。

引用次数: 0

Liver Tissueoid on-a-Chip Modeling Liver Regeneration and Allograft Rejection 类肝组织芯片模拟肝脏再生和同种异体移植排斥反应

IF 29.4 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Advanced Materials

Pub Date : 2026-02-08 DOI: 10.1002/adma.202521178

Abdul Rahim Chethikkattuveli Salih, Arne Peirsman, Danial Khorsandi, Rafaela Ferrao, Lino Ferreira, Meenakshi Kamaraj, Johnson V. John, Angeles Baquerizo, Vadim Jucaud

The lack of physiologically relevant in vitro models remains a limitation in liver transplantation research. Progress in organ-on-a-chip technologies enables the generation of clinically translatable data in vitro. A vascularized liver tissueoid-on-a-chip (LToC) model is engineered to replicate human liver tissue's structural and functional features for modeling liver regeneration and allograft rejection. The LToC comprises a microfluidic device containing donor-matched human hepatic progenitor cells and intrahepatic portal vein endothelial cells embedded in a fibrin matrix and maintained in dynamic culture for 49 days. The system supports self-assembly into a perfusable microvascular network and liver lobule-like architecture, with >95% cell viability, stable vascular integrity, and active hepatic function (albumin, urea, complement factors, and hepatocyte growth factor secretion). The mature tissueoid includes hepatocytes (CK18⁺, albumin⁺, CYP2D6⁺), cholangiocytes (CK19⁺, EPCAM⁺), Kupffer cells (CD68⁺), stellate cells (PDGFR-β⁺), and endothelial cells (CD31⁺). Perfusion with allogeneic T cells induces cellular rejection, characterized by decreased viability, endothelial disruption, hepatic marker loss, HLA-I upregulation, and a proinflammatory cytokine response (IL-6, TNF-α, IL-1β, IFN-γ, granzyme A and B, and perforin). The LToC provides a physiologically relevant platform for studying immune-mediated liver injury, tissue regeneration, and allograft rejection, with potential applications in immunosuppressive drug testing and personalized transplant medicine.

缺乏与生理相关的体外模型仍然是肝移植研究的一个限制。器官芯片技术的进步使得在体外产生临床可翻译的数据成为可能。血管化肝类组织芯片（LToC）模型旨在复制人类肝组织的结构和功能特征，用于模拟肝脏再生和异体移植排斥反应。LToC包括一个微流体装置，其中包含供体匹配的人肝祖细胞和肝内门静脉内皮细胞，包埋在纤维蛋白基质中，并在动态培养中保持49天。该系统支持自组装成可灌注的微血管网络和肝小叶样结构，具有95%的细胞活力、稳定的血管完整性和活跃的肝功能（白蛋白、尿素、补体因子和肝细胞生长因子分泌）。成熟的类组织包括肝细胞（CK18+、白蛋白+、CYP2D6+）、胆管细胞（CK19+、EPCAM+）、库普佛细胞（CD68+）、星状细胞（PDGFR-β+）和内皮细胞（CD31+）。同种异体T细胞灌注诱导细胞排斥反应，其特征是活力降低、内皮破坏、肝脏标志物丧失、hla -1上调和促炎细胞因子反应（IL-6、TNF-α、IL-1β、IFN-γ、颗粒酶a和B和穿孔素）。LToC为研究免疫介导的肝损伤、组织再生和同种异体移植排斥提供了一个生理学相关的平台，在免疫抑制药物测试和个性化移植医学中具有潜在的应用前景。

{"title":"Liver Tissueoid on-a-Chip Modeling Liver Regeneration and Allograft Rejection","authors":"Abdul Rahim Chethikkattuveli Salih, Arne Peirsman, Danial Khorsandi, Rafaela Ferrao, Lino Ferreira, Meenakshi Kamaraj, Johnson V. John, Angeles Baquerizo, Vadim Jucaud","doi":"10.1002/adma.202521178","DOIUrl":"https://doi.org/10.1002/adma.202521178","url":null,"abstract":"The lack of physiologically relevant in vitro models remains a limitation in liver transplantation research. Progress in organ-on-a-chip technologies enables the generation of clinically translatable data in vitro. A vascularized liver tissueoid-on-a-chip (LToC) model is engineered to replicate human liver tissue's structural and functional features for modeling liver regeneration and allograft rejection. The LToC comprises a microfluidic device containing donor-matched human hepatic progenitor cells and intrahepatic portal vein endothelial cells embedded in a fibrin matrix and maintained in dynamic culture for 49 days. The system supports self-assembly into a perfusable microvascular network and liver lobule-like architecture, with >95% cell viability, stable vascular integrity, and active hepatic function (albumin, urea, complement factors, and hepatocyte growth factor secretion). The mature tissueoid includes hepatocytes (CK18+, albumin+, CYP2D6+), cholangiocytes (CK19+, EPCAM+), Kupffer cells (CD68+), stellate cells (PDGFR-β+), and endothelial cells (CD31+). Perfusion with allogeneic T cells induces cellular rejection, characterized by decreased viability, endothelial disruption, hepatic marker loss, HLA-I upregulation, and a proinflammatory cytokine response (IL-6, TNF-α, IL-1β, IFN-γ, granzyme A and B, and perforin). The LToC provides a physiologically relevant platform for studying immune-mediated liver injury, tissue regeneration, and allograft rejection, with potential applications in immunosuppressive drug testing and personalized transplant medicine.","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"5 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2026-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146138749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0