Yang Guo, Shenghong Liu, Tao Hu, Xiang Lin, Lintao Du, Zhuo Diao, Gaohang Huo, Decai Ouyang, Wei Si, Zhen Cui, Huiqiao Li, Yuan Li, Tianyou Zhai
Ultrafast and reliable visual perception is essential for obstacle avoidance in autonomous driving, where split-second decisions must be made in complex, high-speed environments, yet remains constrained by the limited temporal resolution and processing latency of conventional devices. Here, inspired by the exceptional temporal resolution of falcon vision systems (>150 Hz), we develop a neuromorphic vision sensor capable of ultrafast, edge-selective perception for dynamic traffic scenarios. The sensor leverages vertically stacked, edge-rich SnS2/MoS2 van der Waals heterostructures, in which a high density of atomic-scale interfaces and defective edges enables enhanced light-matter interactions and rapid carrier dynamics. These structural advantages endow the Falcon Vision Sensor (FVS) with synaptic plasticity (PPF = 201%, LTP = 1300s), high refresh rate (250 Hz), and intrinsic erasure behaviors, closely mimicking the temporal precision and motion discrimination features of falcon vision. When the synaptic devices are integrated with computing modules, the system achieves real-time obstacle detection, along with a directional motion recognition accuracy of 98.89%. This work demonstrates a robust biologically inspired visual intelligence, offering a compact, low-latency solution for next-generation autonomous vehicles and edge AI applications requiring rapid environmental responsiveness.
{"title":"Falcon Vision-Inspired Ultrafast Traffic Obstacle Avoidance Based on 2D Edge-Rich van de Waals Heterostructures","authors":"Yang Guo, Shenghong Liu, Tao Hu, Xiang Lin, Lintao Du, Zhuo Diao, Gaohang Huo, Decai Ouyang, Wei Si, Zhen Cui, Huiqiao Li, Yuan Li, Tianyou Zhai","doi":"10.1002/adma.202512548","DOIUrl":"https://doi.org/10.1002/adma.202512548","url":null,"abstract":"Ultrafast and reliable visual perception is essential for obstacle avoidance in autonomous driving, where split-second decisions must be made in complex, high-speed environments, yet remains constrained by the limited temporal resolution and processing latency of conventional devices. Here, inspired by the exceptional temporal resolution of falcon vision systems (>150 Hz), we develop a neuromorphic vision sensor capable of ultrafast, edge-selective perception for dynamic traffic scenarios. The sensor leverages vertically stacked, edge-rich SnS<sub>2</sub>/MoS<sub>2</sub> van der Waals heterostructures, in which a high density of atomic-scale interfaces and defective edges enables enhanced light-matter interactions and rapid carrier dynamics. These structural advantages endow the Falcon Vision Sensor (FVS) with synaptic plasticity (PPF = 201%, LTP = 1300s), high refresh rate (250 Hz), and intrinsic erasure behaviors, closely mimicking the temporal precision and motion discrimination features of falcon vision. When the synaptic devices are integrated with computing modules, the system achieves real-time obstacle detection, along with a directional motion recognition accuracy of 98.89%. This work demonstrates a robust biologically inspired visual intelligence, offering a compact, low-latency solution for next-generation autonomous vehicles and edge AI applications requiring rapid environmental responsiveness.","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"5 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2026-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146139025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The construction and integration of curvature govern the structure and function of materials based on 2D sheets, yet achieving ultrafast and scalable curvature programming remains a major challenge. We rapidly generate large stress mismatches by combining an ultrafast stress-relaxing diselenide-containing polyurethane with an ultraslow stress-relaxing disulfide-containing polyurethane. Coupled with modular components and compression, this mismatch enables localized, directional loading of high stress with excellent scalability. Using this strategy, 2D polymer sheets achieve 180° bending within 10 s of UV irradiation, yielding a curvature-programming rate 15-fold faster than state-of-the-art methods. Furthermore, origami modules, which display a 37-fold enhancement in compressive performance, can be obtained through mass production and assembled into complex 3D architectures. This rapid, high-curvature programming approach offers efficiency, mechanical robustness, and scalability, advancing the practical deployment of origami-based metamaterials.
{"title":"Ultrafast Programming of Large Curvature Based on Selenium-Sulfur Dynamic Metathesis","authors":"Ruiyang Wen, Chenglin Zhang, Chaozheng Miao, Wanting Huang, Rui Quan, Ruohan Huang, Han Wu, Zehuan Huang, Yizheng Tan, Huaping Xu","doi":"10.1002/adma.202523642","DOIUrl":"https://doi.org/10.1002/adma.202523642","url":null,"abstract":"The construction and integration of curvature govern the structure and function of materials based on 2D sheets, yet achieving ultrafast and scalable curvature programming remains a major challenge. We rapidly generate large stress mismatches by combining an ultrafast stress-relaxing diselenide-containing polyurethane with an ultraslow stress-relaxing disulfide-containing polyurethane. Coupled with modular components and compression, this mismatch enables localized, directional loading of high stress with excellent scalability. Using this strategy, 2D polymer sheets achieve 180° bending within 10 s of UV irradiation, yielding a curvature-programming rate 15-fold faster than state-of-the-art methods. Furthermore, origami modules, which display a 37-fold enhancement in compressive performance, can be obtained through mass production and assembled into complex 3D architectures. This rapid, high-curvature programming approach offers efficiency, mechanical robustness, and scalability, advancing the practical deployment of origami-based metamaterials.","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"30 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2026-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146138747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abdul Rahim Chethikkattuveli Salih, Arne Peirsman, Danial Khorsandi, Rafaela Ferrao, Lino Ferreira, Meenakshi Kamaraj, Johnson V. John, Angeles Baquerizo, Vadim Jucaud
The lack of physiologically relevant in vitro models remains a limitation in liver transplantation research. Progress in organ-on-a-chip technologies enables the generation of clinically translatable data in vitro. A vascularized liver tissueoid-on-a-chip (LToC) model is engineered to replicate human liver tissue's structural and functional features for modeling liver regeneration and allograft rejection. The LToC comprises a microfluidic device containing donor-matched human hepatic progenitor cells and intrahepatic portal vein endothelial cells embedded in a fibrin matrix and maintained in dynamic culture for 49 days. The system supports self-assembly into a perfusable microvascular network and liver lobule-like architecture, with >95% cell viability, stable vascular integrity, and active hepatic function (albumin, urea, complement factors, and hepatocyte growth factor secretion). The mature tissueoid includes hepatocytes (CK18+, albumin+, CYP2D6+), cholangiocytes (CK19+, EPCAM+), Kupffer cells (CD68+), stellate cells (PDGFR-β+), and endothelial cells (CD31+). Perfusion with allogeneic T cells induces cellular rejection, characterized by decreased viability, endothelial disruption, hepatic marker loss, HLA-I upregulation, and a proinflammatory cytokine response (IL-6, TNF-α, IL-1β, IFN-γ, granzyme A and B, and perforin). The LToC provides a physiologically relevant platform for studying immune-mediated liver injury, tissue regeneration, and allograft rejection, with potential applications in immunosuppressive drug testing and personalized transplant medicine.
{"title":"Liver Tissueoid on-a-Chip Modeling Liver Regeneration and Allograft Rejection","authors":"Abdul Rahim Chethikkattuveli Salih, Arne Peirsman, Danial Khorsandi, Rafaela Ferrao, Lino Ferreira, Meenakshi Kamaraj, Johnson V. John, Angeles Baquerizo, Vadim Jucaud","doi":"10.1002/adma.202521178","DOIUrl":"https://doi.org/10.1002/adma.202521178","url":null,"abstract":"The lack of physiologically relevant in vitro models remains a limitation in liver transplantation research. Progress in organ-on-a-chip technologies enables the generation of clinically translatable data in vitro. A vascularized liver tissueoid-on-a-chip (LToC) model is engineered to replicate human liver tissue's structural and functional features for modeling liver regeneration and allograft rejection. The LToC comprises a microfluidic device containing donor-matched human hepatic progenitor cells and intrahepatic portal vein endothelial cells embedded in a fibrin matrix and maintained in dynamic culture for 49 days. The system supports self-assembly into a perfusable microvascular network and liver lobule-like architecture, with >95% cell viability, stable vascular integrity, and active hepatic function (albumin, urea, complement factors, and hepatocyte growth factor secretion). The mature tissueoid includes hepatocytes (CK18<sup>+</sup>, albumin<sup>+</sup>, CYP2D6<sup>+</sup>), cholangiocytes (CK19<sup>+</sup>, EPCAM<sup>+</sup>), Kupffer cells (CD68<sup>+</sup>), stellate cells (PDGFR-β<sup>+</sup>), and endothelial cells (CD31<sup>+</sup>). Perfusion with allogeneic T cells induces cellular rejection, characterized by decreased viability, endothelial disruption, hepatic marker loss, HLA-I upregulation, and a proinflammatory cytokine response (IL-6, TNF-α, IL-1β, IFN-γ, granzyme A and B, and perforin). The LToC provides a physiologically relevant platform for studying immune-mediated liver injury, tissue regeneration, and allograft rejection, with potential applications in immunosuppressive drug testing and personalized transplant medicine.","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"5 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2026-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146138749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shuang Hong, Yun Cao, Jiangshan Qi, Chuannan Geng, Ruiqing Ye, Lingjing Wei, Yanyan Wang, Boya Zhang, Yu Long, Jiwei Shi, Li Wang, Chen Zhang, Wei Lv, Quan-Hong Yang
The practical deployment of lithium sulfide (Li2S) cathodes in all-solid-state lithium-sulfur batteries (ASSLSBs) is challenged by their poor innate conductivities and high activation barriers. Here, we demonstrate a lattice engineering strategy using Zr4+ substitution to fundamentally activate Li2S. The introduced Zr4+ expands the lattice, creating lithium vacancies that enhance ionic conductivity by two orders of magnitude. Simultaneously, Zr─S orbital hybridization narrows the bandgap for superior electronic conductivity and weakens Li─S bonds to lower the activation energy. This synergistic effect enables a highly reversible solid-state sulfur conversion. As a result, our ASSLSB delivers an ultrahigh energy density of 996.2 Wh kg−1 based on the cathode with a record 65 wt.% electrode-level Li2S content and maintains stability for over 100 cycles, far exceeding the conventional configuration of ∼40 wt.% loading. This strategy establishes a viable pathway toward practical high-energy-density ASSLSBs by fundamentally activating Li2S electrochemistry.
{"title":"High-Valence-Cation-Induced Lattice Expansion for Activating Li2S Cathode in All-Solid-State Lithium-Sulfur Batteries","authors":"Shuang Hong, Yun Cao, Jiangshan Qi, Chuannan Geng, Ruiqing Ye, Lingjing Wei, Yanyan Wang, Boya Zhang, Yu Long, Jiwei Shi, Li Wang, Chen Zhang, Wei Lv, Quan-Hong Yang","doi":"10.1002/adma.72513","DOIUrl":"https://doi.org/10.1002/adma.72513","url":null,"abstract":"The practical deployment of lithium sulfide (Li<sub>2</sub>S) cathodes in all-solid-state lithium-sulfur batteries (ASSLSBs) is challenged by their poor innate conductivities and high activation barriers. Here, we demonstrate a lattice engineering strategy using Zr<sup>4+</sup> substitution to fundamentally activate Li<sub>2</sub>S. The introduced Zr<sup>4</sup><sup>+</sup> expands the lattice, creating lithium vacancies that enhance ionic conductivity by two orders of magnitude. Simultaneously, Zr─S orbital hybridization narrows the bandgap for superior electronic conductivity and weakens Li─S bonds to lower the activation energy. This synergistic effect enables a highly reversible solid-state sulfur conversion. As a result, our ASSLSB delivers an ultrahigh energy density of 996.2 Wh kg<sup>−1</sup> based on the cathode with a record 65 wt.% electrode-level Li<sub>2</sub>S content and maintains stability for over 100 cycles, far exceeding the conventional configuration of ∼40 wt.% loading. This strategy establishes a viable pathway toward practical high-energy-density ASSLSBs by fundamentally activating Li<sub>2</sub>S electrochemistry.","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"45 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2026-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146139097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Shui Liu, Qi Xie, Yongye Xia, Dun Hu, Jingxia Qiang, Yamei Zhang, Bao Zhang, Ce Zhang, Feng Xu
Electromagnetic metasurface integrated microfluidic chips enable a real-time, label-free platform for terahertz trace analysis of volume-limited biomedical samples with suppressed water absorption noise. However, conventional metal-insulator-metal (MIM) metasurface resonators exhibit inherently limited Q-factor and sensitivity due to radiative leakage through open side boundaries. Here, a lattice slot waveguide based on MIM configuration is designed to effectively confine energy within the microfluidic channel and mitigate radiative loss. This trapped mode achieves enhanced sensitivity and Q-factor through synergistic excitation of surface lattice resonance and guided mode resonance under propagation constant matching conditions. Leveraging this platform, an anisotropic detection strategy incorporating a patterned lattice structure is devised to achieve simultaneous polarization multiplexed responses, exhibiting a figure of merit of 135 in both polarizations. Experimental validation demonstrates a limit of detection of 625 pmol mL−1 and a Q-factor of 189 for this polarization multiplexing microfluidic platform. This work offers a unique avenue for enhanced accuracy and efficiency in terahertz biomedical trace analyzing via multidimensional sensing capabilities.
{"title":"Lattice Slot Waveguide for Terahertz Microfluidics Biomedical Trace Analysis","authors":"Shui Liu, Qi Xie, Yongye Xia, Dun Hu, Jingxia Qiang, Yamei Zhang, Bao Zhang, Ce Zhang, Feng Xu","doi":"10.1002/adma.202521964","DOIUrl":"https://doi.org/10.1002/adma.202521964","url":null,"abstract":"Electromagnetic metasurface integrated microfluidic chips enable a real-time, label-free platform for terahertz trace analysis of volume-limited biomedical samples with suppressed water absorption noise. However, conventional metal-insulator-metal (MIM) metasurface resonators exhibit inherently limited Q-factor and sensitivity due to radiative leakage through open side boundaries. Here, a lattice slot waveguide based on MIM configuration is designed to effectively confine energy within the microfluidic channel and mitigate radiative loss. This trapped mode achieves enhanced sensitivity and Q-factor through synergistic excitation of surface lattice resonance and guided mode resonance under propagation constant matching conditions. Leveraging this platform, an anisotropic detection strategy incorporating a patterned lattice structure is devised to achieve simultaneous polarization multiplexed responses, exhibiting a figure of merit of 135 in both polarizations. Experimental validation demonstrates a limit of detection of 625 pmol mL<sup>−1</sup> and a Q-factor of 189 for this polarization multiplexing microfluidic platform. This work offers a unique avenue for enhanced accuracy and efficiency in terahertz biomedical trace analyzing via multidimensional sensing capabilities.","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"161 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2026-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146139091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yousang Won, Boesung Kwon, Pongphak Chidchob, Jeongwoo Lee, Seoyoung Kim, Joon Hak Oh
Neuromorphic computing, which emulates the energy-efficient processing of the human brain, has emerged as a key technology for next-generation artificial intelligence. Integrating sensitivity to circularly polarized light (CPL) provides an additional degree of freedom for optical data encoding, yet practical implementation remains limited by material instability and complex, non-scalable fabrication. This work introduces a chiropto-neuromorphic device that addresses these challenges through a polarized light-induced charge transfer doping mechanism. The system employs a solution-processed bulk heterojunction (BHJ) composed of a chiral boron dipyrromethene (BODIPY) dye and a polymer semiconductor (PBTTT-C12) to translate CPL handedness into a stable nonvolatile memory state. Chirality-dependent charge transfer modulates the polymer's doping level, enabling precise control of synaptic weight. The device emulates key biological synaptic functions, including short- and long-term plasticity, paired-pulse facilitation, and stimulus-dependent plasticity governed by light number, duration, and intensity, while maintaining distinct chiroptical selectivity. Notably, its energy consumption remains at the picojoule (pJ) level per synaptic event, comparable to biological synapses. By introducing chirality as a new control dimension for synaptic modulation, this study demonstrates a scalable and powerful platform for polarization-encoded neuromorphic information processing and establishes a foundation for advanced artificial sensory systems capable of handling complex chiral optical signals.
{"title":"Chiropto-Neuromorphic Devices Based on a Photocatalytic Dye/Polymer Semiconductor Bulk Heterojunction for Circularly Polarized Light Detection and Memorization","authors":"Yousang Won, Boesung Kwon, Pongphak Chidchob, Jeongwoo Lee, Seoyoung Kim, Joon Hak Oh","doi":"10.1002/adma.202523436","DOIUrl":"https://doi.org/10.1002/adma.202523436","url":null,"abstract":"Neuromorphic computing, which emulates the energy-efficient processing of the human brain, has emerged as a key technology for next-generation artificial intelligence. Integrating sensitivity to circularly polarized light (CPL) provides an additional degree of freedom for optical data encoding, yet practical implementation remains limited by material instability and complex, non-scalable fabrication. This work introduces a chiropto-neuromorphic device that addresses these challenges through a polarized light-induced charge transfer doping mechanism. The system employs a solution-processed bulk heterojunction (BHJ) composed of a chiral boron dipyrromethene (BODIPY) dye and a polymer semiconductor (PBTTT-C12) to translate CPL handedness into a stable nonvolatile memory state. Chirality-dependent charge transfer modulates the polymer's doping level, enabling precise control of synaptic weight. The device emulates key biological synaptic functions, including short- and long-term plasticity, paired-pulse facilitation, and stimulus-dependent plasticity governed by light number, duration, and intensity, while maintaining distinct chiroptical selectivity. Notably, its energy consumption remains at the picojoule (pJ) level per synaptic event, comparable to biological synapses. By introducing chirality as a new control dimension for synaptic modulation, this study demonstrates a scalable and powerful platform for polarization-encoded neuromorphic information processing and establishes a foundation for advanced artificial sensory systems capable of handling complex chiral optical signals.","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"241 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2026-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146139100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bihao Hu, Yifan Zhou, Xiaoyuan Zhang, Shibo Xi, Qian He, Lei Wang
With the continuously decreasing levelized cost of renewable electricity, electrocatalytic waste treatment and valorizations have attracted increasing attention as sustainable routes for converting waste molecules into valuable chemicals. Here, we report an energy-efficient strategy that couples nitrate-reduction (NO3R) with sulfide-oxidation reaction (SOR) to simultaneously remediate pollutants and produce value-added chemicals. By utilizing a dual-catalyst composite in which cobalt polyphthalocyanine (CoPc) and copper polyphthalocyanine (CuPc) are co-anchored on carbon nanotubes, we achieve enhanced cathodic ammonia (NH3) production that is well matched with efficient anodic thiosulfate formation. This paired NO3R-SOR system enables the direct synthesis of ammonium thiosulfate, a valuable fertilizer feedstock, via simple mixing of the anolyte and catholyte. Kinetic analysis reveals that the improved NH3 production originates from a relay of the *NO2 from Cu- to Co-sites, allowing both active-sites to bypass their respective rate-limiting steps. Based on these insights, we demonstrate an integrated NO3R||SOR system that substantially lowers the required cell voltage compared with conventional NO3R||OER (oxygen evolution reaction) systems, achieving a 64% reduction in energy consumption at 200 mA cm−2. Preliminary techno-economic analysis further suggests a substantial increase in energy-normalized product value, highlighting a sustainable approach for coupled waste treatment and chemical production.
随着可再生电力平准化成本的不断降低，电催化废物处理和增值作为将废物分子转化为有价值化学品的可持续途径越来越受到关注。在这里，我们报告了一种节能策略，将硝酸盐还原（NO3R）与硫化物氧化反应（SOR）结合起来，同时修复污染物并产生增值化学品。通过使用双催化剂复合材料，其中钴聚酞菁（CoPc）和铜聚酞菁（CuPc）共锚定在碳纳米管上，我们实现了阴极氨（NH3）的增强生产，这与高效的阳极硫代硫酸盐形成很好地匹配。这种配对的NO3R-SOR系统可以通过简单的阳极液和阴极液混合直接合成硫代硫酸铵，这是一种有价值的肥料原料。动力学分析表明，NH3的生成源于*NO2从Cu-到co -位点的接力反应，从而使两个活性位点绕过各自的限速步骤。基于这些见解，我们展示了一个集成的NO3R b| |SOR系统，与传统的NO3R||OER（氧释放反应）系统相比，该系统大大降低了所需的电池电压，在200 mA cm - 2时实现了64%的能耗降低。初步的技术经济分析进一步表明，能源标准化产品价值大幅增加，突出了废物处理和化学品生产相结合的可持续办法。
{"title":"Toward Energy Efficient Electrochemical Valorization of Waste Nitrate and Sulfide","authors":"Bihao Hu, Yifan Zhou, Xiaoyuan Zhang, Shibo Xi, Qian He, Lei Wang","doi":"10.1002/adma.202517966","DOIUrl":"https://doi.org/10.1002/adma.202517966","url":null,"abstract":"With the continuously decreasing levelized cost of renewable electricity, electrocatalytic waste treatment and valorizations have attracted increasing attention as sustainable routes for converting waste molecules into valuable chemicals. Here, we report an energy-efficient strategy that couples nitrate-reduction (NO<sub>3</sub>R) with sulfide-oxidation reaction (SOR) to simultaneously remediate pollutants and produce value-added chemicals. By utilizing a dual-catalyst composite in which cobalt polyphthalocyanine (CoPc) and copper polyphthalocyanine (CuPc) are co-anchored on carbon nanotubes, we achieve enhanced cathodic ammonia (NH<sub>3</sub>) production that is well matched with efficient anodic thiosulfate formation. This paired NO<sub>3</sub>R-SOR system enables the direct synthesis of ammonium thiosulfate, a valuable fertilizer feedstock, via simple mixing of the anolyte and catholyte. Kinetic analysis reveals that the improved NH<sub>3</sub> production originates from a relay of the <sup>*</sup>NO<sub>2</sub> from Cu- to Co-sites, allowing both active-sites to bypass their respective rate-limiting steps. Based on these insights, we demonstrate an integrated NO<sub>3</sub>R||SOR system that substantially lowers the required cell voltage compared with conventional NO<sub>3</sub>R||OER (oxygen evolution reaction) systems, achieving a 64% reduction in energy consumption at 200 mA cm<sup>−2</sup>. Preliminary techno-economic analysis further suggests a substantial increase in energy-normalized product value, highlighting a sustainable approach for coupled waste treatment and chemical production.","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"35 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2026-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146138745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Qiaoling Xu, Lei Zhang, Xiayu Li, Weihang Xu, Linyi Ren, Mai Xu, Yingtang Zhou, Hermenegildo Garcia
Efficient oxygen reduction reaction (ORR) requires coordination of oxygen adsorption, transport, and catalysis at active sites. Yet most studies address only one step, overlooking whole-pathway O2 regulation and thus limiting performance. Here, we report a bioinspired Co-doped Fe2P on N-doped carbon featuring a hierarchical eucalyptus-like nanoarchitecture, engineered to regulate oxygen throughout the electrochemical cycle, where Fe–P–Co hetero-coordinated bridges anchored to the carbon substrate through Fe─N bonds induce strong electronic coupling and polarization. The hierarchical structure generated local electric fields that enriched OH− and O2, while multilevel porosity accelerated oxygen transport. This enabled coordinated optimization of oxygen adsorption, transfer, and active-site electronic configuration. This nanohybrid achieved a half-wave potential of 0.938 V vs. RHE, sustained discharge in Al-air batteries for 373 h, and delivered an energy density of 3487 Wh/kg. Theoretical simulations revealed that Co-doping shortened Fe─P bonds and tuned the Fe electronic environment, lowering the d-band center and weakening Fe 3d-O 2p interactions, which reduced the *OH desorption barrier and accelerated ORR kinetics. In situ Raman spectroscopy revealed that Fe–P–Co bridges served as active centers facilitating *OH release during ORR. These findings indicate that integrating hierarchical architecture, hetero-coordinated Fe–P–Co bridges, and electronic-state modulation enables whole-pathway O2 management for efficient oxygen electrocatalysis.
有效的氧还原反应（ORR）需要氧在活性位点的吸附、转运和催化的协调。然而，大多数研究只解决了一个步骤，忽略了全途径的氧气调节，从而限制了表现。在这里，我们报告了一种生物启发的共掺杂Fe2P在N掺杂碳上，具有层次化桉树状纳米结构，用于调节整个电化学循环中的氧气，其中Fe - p -co异质配位桥通过Fe─N键锚定在碳衬底上，诱导强电子耦合和极化。分层结构产生的局部电场富集了OH−和O2，而多层孔隙加速了氧的输运。这使得氧吸附、转移和活性位点电子构型的协调优化成为可能。与RHE相比，该纳米混合材料的半波电位为0.938 V，在铝空气电池中持续放电373 h，能量密度为3487 Wh/kg。理论模拟表明，共掺杂缩短了Fe─P键，调整了Fe电子环境，降低了d波段中心，减弱了Fe 3d-O - 2p相互作用，从而降低了*OH解吸势垒，加速了ORR动力学。原位拉曼光谱显示Fe-P-Co桥在ORR过程中作为促进*OH释放的活性中心。这些发现表明，将层次结构、Fe-P-Co异质配位桥和电子态调制集成在一起，可以实现高效氧电催化的全途径O2管理。
{"title":"Bio-Inspired Hierarchical Nanoreactor With Hetero-Coordinated Fe–P–Co Bridges for Whole-Pathway-Regulated Electrocatalytic Oxygen Reduction","authors":"Qiaoling Xu, Lei Zhang, Xiayu Li, Weihang Xu, Linyi Ren, Mai Xu, Yingtang Zhou, Hermenegildo Garcia","doi":"10.1002/adma.202522781","DOIUrl":"https://doi.org/10.1002/adma.202522781","url":null,"abstract":"Efficient oxygen reduction reaction (ORR) requires coordination of oxygen adsorption, transport, and catalysis at active sites. Yet most studies address only one step, overlooking whole-pathway O<sub>2</sub> regulation and thus limiting performance. Here, we report a bioinspired Co-doped Fe<sub>2</sub>P on N-doped carbon featuring a hierarchical eucalyptus-like nanoarchitecture, engineered to regulate oxygen throughout the electrochemical cycle, where Fe–P–Co hetero-coordinated bridges anchored to the carbon substrate through Fe─N bonds induce strong electronic coupling and polarization. The hierarchical structure generated local electric fields that enriched OH<sup>−</sup> and O<sub>2</sub>, while multilevel porosity accelerated oxygen transport. This enabled coordinated optimization of oxygen adsorption, transfer, and active-site electronic configuration. This nanohybrid achieved a half-wave potential of 0.938 V vs. RHE, sustained discharge in Al-air batteries for 373 h, and delivered an energy density of 3487 Wh/kg. Theoretical simulations revealed that Co-doping shortened Fe─P bonds and tuned the Fe electronic environment, lowering the d-band center and weakening Fe 3d-O 2p interactions, which reduced the *OH desorption barrier and accelerated ORR kinetics. In situ Raman spectroscopy revealed that Fe–P–Co bridges served as active centers facilitating *OH release during ORR. These findings indicate that integrating hierarchical architecture, hetero-coordinated Fe–P–Co bridges, and electronic-state modulation enables whole-pathway O<sub>2</sub> management for efficient oxygen electrocatalysis.","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"90 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2026-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146138748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hardik Makkar, Nghi Tran, Yu-Chang Chen, Kang I Ko, Rebecca G Wells, Kyle H Vining
Periodontal disease is characterized by inflamed gingival tissues and degradation of the gingival extracellular matrix (ECM), yet the role of mechanical cues remains poorly understood. Gingival ECM in periodontal disease showed reduced fibrillar collagen compared to healthy samples. We hypothesized that ECM softening in periodontal disease contributes to inflammation by dysregulating gingival fibroblasts (GFs). A mechanically tunable hydrogel model of the gingival ECM was developed to investigate the mechano-immune crosstalk. Stiff and soft collagen-alginate hydrogels matched the rheological properties of healthy and diseased gingival biopsies respectively. Human donor GFs encapsulated in these stiff hydrogels showed significantly suppressed toll-like receptor-mediated inflammatory responses compared to those in soft hydrogels. The non-canonical NFκB pathway and epigenetic nuclear organization directed stiffness-dependent inflammatory responses of GFs. The direct impact of mechanical cues on immune responses was investigated ex vivo by co-culture of donor-derived human GFs with myeloid cells and in human gingival explants. Myeloid progenitors co-cultured with GFs in stiff hydrogels differentiated into immunomodulatory dendritic cells. Ex vivo crosslinking of human gingival tissue increased stiffness and reduced the production of inflammatory cytokines. Gingival mechano-immune regulation offers a novel approach to biomaterial-based treatments for periodontitis.
{"title":"Matrix Stiffness Governs Fibroblasts' Regulation of Gingival Immune Homeostasis.","authors":"Hardik Makkar, Nghi Tran, Yu-Chang Chen, Kang I Ko, Rebecca G Wells, Kyle H Vining","doi":"10.1002/adma.202520717","DOIUrl":"https://doi.org/10.1002/adma.202520717","url":null,"abstract":"<p><p>Periodontal disease is characterized by inflamed gingival tissues and degradation of the gingival extracellular matrix (ECM), yet the role of mechanical cues remains poorly understood. Gingival ECM in periodontal disease showed reduced fibrillar collagen compared to healthy samples. We hypothesized that ECM softening in periodontal disease contributes to inflammation by dysregulating gingival fibroblasts (GFs). A mechanically tunable hydrogel model of the gingival ECM was developed to investigate the mechano-immune crosstalk. Stiff and soft collagen-alginate hydrogels matched the rheological properties of healthy and diseased gingival biopsies respectively. Human donor GFs encapsulated in these stiff hydrogels showed significantly suppressed toll-like receptor-mediated inflammatory responses compared to those in soft hydrogels. The non-canonical NFκB pathway and epigenetic nuclear organization directed stiffness-dependent inflammatory responses of GFs. The direct impact of mechanical cues on immune responses was investigated ex vivo by co-culture of donor-derived human GFs with myeloid cells and in human gingival explants. Myeloid progenitors co-cultured with GFs in stiff hydrogels differentiated into immunomodulatory dendritic cells. Ex vivo crosslinking of human gingival tissue increased stiffness and reduced the production of inflammatory cytokines. Gingival mechano-immune regulation offers a novel approach to biomaterial-based treatments for periodontitis.</p>","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":" ","pages":"e20717"},"PeriodicalIF":26.8,"publicationDate":"2026-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146140298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Repairing abnormal vessels in the complex fluidic and biological environment of blood remains challenging. Current approaches, such as non-adhesive polymeric sealants or vessel coiling, have unsatisfactory outcomes. Here, we present an injectable magnetoactive adhesive hydrogel (iMAH) for vascular repair in the challenging blood environment. Designed with biocompatible functional components, including the superparamagnetic component, a bio-inspired tissue adhesive, and quick-crosslinking agents, the catheter-deployable iMAH can be magnetically guided to a targeted site, quickly crosslink within approximately 2 s, and strongly adhere to the vessel surface in dynamic conditions with circulating and pressurized blood. Moreover, magnetic actuation enables targeted gel deployment and can drive the iMAH into a narrow and confined space, squeezing out interfacial fluid to facilitate high-strength tissue adhesion, as systematically investigated in vitro. Magnetically controlled delivery of iMAH for vascular repair has been demonstrated in a large-animal beagle dog model; branching lumbar arteries from the abdominal aorta, mimicking the opening of a ruptured artery, were successfully embolized under magnetic guidance using a 5-axis magnetic vascular robot. With these demonstrated features, magnetically controlled delivery of injectable magnetoactive adhesive hydrogel provides a promising solution for vascular repair such as sealing ruptured vessels or embolizing abnormal arteries in the challenging blood environment.
{"title":"Magnetically Controlled Delivery of Injectable Magnetoactive Adhesive Hydrogel for Vascular Repair in the Challenging Blood Environment","authors":"Donglin Xie, Zhuopeng Liu, Zuo Pu, Jing Liu, Maosen Deng, Jiang Bian, Shuang Guo, Hui Zong, Yong Jiang, Jun Yue, Chang Shu, Zhe Li","doi":"10.1002/adma.202523024","DOIUrl":"https://doi.org/10.1002/adma.202523024","url":null,"abstract":"Repairing abnormal vessels in the complex fluidic and biological environment of blood remains challenging. Current approaches, such as non-adhesive polymeric sealants or vessel coiling, have unsatisfactory outcomes. Here, we present an injectable magnetoactive adhesive hydrogel (iMAH) for vascular repair in the challenging blood environment. Designed with biocompatible functional components, including the superparamagnetic component, a bio-inspired tissue adhesive, and quick-crosslinking agents, the catheter-deployable iMAH can be magnetically guided to a targeted site, quickly crosslink within approximately 2 s, and strongly adhere to the vessel surface in dynamic conditions with circulating and pressurized blood. Moreover, magnetic actuation enables targeted gel deployment and can drive the iMAH into a narrow and confined space, squeezing out interfacial fluid to facilitate high-strength tissue adhesion, as systematically investigated in vitro. Magnetically controlled delivery of iMAH for vascular repair has been demonstrated in a large-animal beagle dog model; branching lumbar arteries from the abdominal aorta, mimicking the opening of a ruptured artery, were successfully embolized under magnetic guidance using a 5-axis magnetic vascular robot. With these demonstrated features, magnetically controlled delivery of injectable magnetoactive adhesive hydrogel provides a promising solution for vascular repair such as sealing ruptured vessels or embolizing abnormal arteries in the challenging blood environment.","PeriodicalId":114,"journal":{"name":"Advanced Materials","volume":"72 1","pages":""},"PeriodicalIF":29.4,"publicationDate":"2026-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146139099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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