Engineering最新文献

英文中文

Vision Sensing for Intelligent Driving: Technical Challenges and Innovative Solutions 智能驾驶的视觉传感：技术挑战和创新解决方案

IF 11.6 1区工程技术 Q1 ENGINEERING, MULTIDISCIPLINARY

Engineering

Pub Date : 2026-02-01 Epub Date: 2025-07-14 DOI: 10.1016/j.eng.2025.06.038

Xinle Gong , Zhihua Zhong

引用次数: 0

Can DNA Be Glycosylated? DNA可以糖基化吗？

IF 11.6 1区工程技术 Q1 ENGINEERING, MULTIDISCIPLINARY

Engineering

Pub Date : 2026-02-01 Epub Date: 2025-04-16 DOI: 10.1016/j.eng.2025.04.006

Wei Wang

引用次数: 0

From Flu to Therapy: Development of Influenza Viruses as Platforms for Combating Infections and Cancer 从流感到治疗：流感病毒作为对抗感染和癌症平台的发展

IF 11.6 1区工程技术 Q1 ENGINEERING, MULTIDISCIPLINARY

Engineering

Pub Date : 2026-02-01 Epub Date: 2025-12-18 DOI: 10.1016/j.eng.2025.12.007

Demin Zhou , Dezhong Ji , Jiandong Jiang

引用次数: 0

Multi-Frequency Dual-Echo Magnetic Resonance Imaging for Real-Time and Artifact-Free Magnetic Robot Navigation 实时无伪影磁机器人导航的多频双回波磁共振成像

IF 11.6 1区工程技术 Q1 ENGINEERING, MULTIDISCIPLINARY

Engineering

Pub Date : 2026-02-01 Epub Date: 2025-07-01 DOI: 10.1016/j.eng.2025.04.027

Renkuan Zhai , Zhangqi Pan , Yuanshi Kou , Chuang Yang , Yang Ruan , Chenli Xu , Linjie He , Jianfeng Zang

Magnetic resonance imaging (MRI) systems, outfitted with internal gradient coils capable of manipulating magnetic gradients in three-dimensional (3D) space, offer an intriguing platform for the navigation of medical magnetic robots. These robots offer considerable promise for applications in minimally invasive therapy, targeted drug delivery, and theranostic interventions. However, an MRI-driven robot presents a challenging contradiction between real-time control and image resolution, resulting in suboptimal tracking accuracy—attributed to the inefficiency of conventional signal acquisition and the presence of metal artifacts. In this paper, we report a multi-frequency excitation sequence with dual-echo (MFDE) that reduces the repetition time (TR) to 30 ms, allowing the precise tracking of magnetic particles (relative error < 1%) without artifacts. The duty cycle of the driving gradient is as high as 77%, and perturbations from the imaging gradients are eliminated. Expanding on these foundations, we adapted our technique to 3D operations. We established an integrated platform for imaging and motion control by creating a three-view window and developing a control joystick to be used in conjunction with the platform. Demonstrations of navigation in a maze, in a phantom vessel, and in vivo animal trials validate its feasibility and effectiveness, providing a significant advancement in the field of MRI-guided magnetic robot control.

磁共振成像（MRI）系统配备了内部梯度线圈，能够在三维（3D）空间中操纵磁梯度，为医用磁性机器人的导航提供了一个有趣的平台。这些机器人在微创治疗、靶向药物输送和治疗干预方面的应用前景可观。然而，mri驱动的机器人在实时控制和图像分辨率之间存在一个具有挑战性的矛盾，由于传统信号采集效率低下和金属伪影的存在，导致跟踪精度不理想。在本文中，我们报告了一种具有双回波（MFDE）的多频率激励序列，该序列将重复时间（TR）减少到30 ms，允许精确跟踪磁颗粒（相对误差<；1%）而不会产生伪影。驱动梯度占空比高达77%，消除了成像梯度的扰动。在这些基础上进行扩展，我们将我们的技术应用于3D操作。我们通过创建一个三视图窗口和开发一个与该平台结合使用的控制操纵杆，建立了一个集成的成像和运动控制平台。迷宫导航演示、幻船导航演示和活体动物实验验证了该方法的可行性和有效性，为mri引导磁机器人控制领域提供了重大进展。

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引用次数: 0

Neural Network-Based Switching Output Regulation Control for High-Speed Nano-Positioning Stages 基于神经网络的高速纳米定位平台开关输出调节控制

IF 11.6 1区工程技术 Q1 ENGINEERING, MULTIDISCIPLINARY

Engineering

Pub Date : 2026-02-01 Epub Date: 2025-07-26 DOI: 10.1016/j.eng.2025.07.023

Hongwei Sun , Ning Xing , Jiayu Zou , Yuqi Rong , Yang Shi , Han Ding , Hai-Tao Zhang

This study establishes a high-speed nano-positioning stage composed of a symmetrically driven structure with multiple parallel-bonded thin piezoelectric ceramic layers capable of performing micro- or nano-scale manipulations. Accordingly, a neural-network-based switching output regulation controller (NN-SORC) was developed to compensate for the associated hysteresis nonlinearity. To address the challenges of slow floating-point computation speeds and low compilation efficiency, a closed-loop control system with a field-programmable gate array–central processing unit (FPGA–CPU) dual-layer data-processing framework was developed. A feedback linearization method was designed to linearize the hysteresis nonlinearity of the framework, resulting in a switching-tracking error system. With the assistance of Lyapunov theory and an average dwell time technique, sufficient conditions were derived to ensure the asymptotic stability of the NN-SORC governing closed-loop system using the switching reference signals often encountered in realistic micro-/nano-scale detection and manufacturing processes. Finally, extensive comparative experiments were conducted to verify the effectiveness and superiority of the proposed NN-SORC scheme.

本研究建立了一种高速纳米定位平台，该平台由对称驱动结构和多个平行键合的薄压电陶瓷层组成，能够进行微纳米级的操作。为此，开发了一种基于神经网络的开关输出调节控制器（NN-SORC）来补偿相关的滞后非线性。针对浮点运算速度慢、编译效率低的问题，设计了一种采用现场可编程门阵列-中央处理器（FPGA-CPU）双层数据处理框架的闭环控制系统。设计了一种反馈线性化方法，对框架的滞后非线性进行线性化处理，得到了切换跟踪误差系统。利用李雅普诺夫理论和平均停留时间技术，推导了利用实际微/纳米尺度检测和制造过程中经常遇到的开关参考信号，保证NN-SORC控制闭环系统渐近稳定的充分条件。最后，进行了大量的对比实验，验证了所提出的NN-SORC方案的有效性和优越性。

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引用次数: 0

Moving Beyond a Zero Tolerance Mindset: Embracing Action Errors in Construction 超越零容忍心态：拥抱施工中的行动错误

IF 11.6 1区工程技术 Q1 ENGINEERING, MULTIDISCIPLINARY

Engineering

Pub Date : 2026-02-01 Epub Date: 2025-10-30 DOI: 10.1016/j.eng.2025.10.018

Peter E.D. Love , Jane Matthews , Weili Fang

Action errors—unintentional deviations from goals, rules, or standards—are an inevitable part of work in construction. Understanding how individuals and organizations can embrace and “learn through errors” (i.e., how to handle them effectively) is crucial for contributing to project success. However, within construction, a prevailing belief persists that errors can and should be eliminated, fostering a zero-tolerance mindset. Organizations that adopt this mindset risk stifling their capacity to learn, innovate, and improve profitability. While errors can indeed have negative consequences, they also play a vital role in enabling learning and innovation. Given the limited empirical research on action errors in construction, this paper aims to stimulate inquiry into this promising area of study. It briefly outlines different forms of error orientation and proposes directions for future research relevant to construction organizations. The contributions of this paper are twofold, as it: ① advocates for construction organizations to broaden their understanding of errors to enhance their learning capability and ② identifies ways in which organizations can improve their capacity to learn and innovate through error management.

动作错误——无意中偏离目标、规则或标准——是构建工作中不可避免的一部分。了解个人和组织如何接受并“从错误中学习”（即，如何有效地处理错误）对于项目成功至关重要。然而，在建设中，一种普遍的信念坚持认为错误可以而且应该被消除，形成了一种零容忍的心态。采用这种思维方式的组织可能会扼杀他们学习、创新和提高盈利能力的能力。虽然错误确实会产生负面影响，但它们也在促进学习和创新方面发挥着至关重要的作用。鉴于建构行为错误的实证研究有限，本文旨在激发对这一有前景的研究领域的探索。简要概述了错误导向的不同形式，并提出了与施工组织相关的未来研究方向。本文的贡献是双重的，因为它：①倡导建筑组织拓宽他们对错误的理解，以提高他们的学习能力；②确定了组织可以通过错误管理来提高他们的学习和创新能力的方法。

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引用次数: 0

Absolute Quantification of Aging-Associated Glycans in IgG for Biological Age Prediction: Insights from Glycomics and Transcriptomics 用于生物年龄预测的IgG中衰老相关聚糖的绝对定量：糖组学和转录组学的见解

IF 11.6 1区工程技术 Q1 ENGINEERING, MULTIDISCIPLINARY

Engineering

Pub Date : 2026-02-01 Epub Date: 2025-08-27 DOI: 10.1016/j.eng.2025.07.042

Huijuan Zhao , Jiteng Fan , Jing Han, Wenjun Qin, Jichen Sha, Weilong Zhang, Yong Gu, Xiaonan Ma, Jianxin Gu, Shifang Ren

Immunoglobulin G (IgG) N-glycans are associated with aging. In this study, we introduce a novel strategy for discovering aging-associated IgG glycans and establish a prediction model on the basis of their absolute concentration alterations. We employed glycomic quantification technology to identify alterations in the amount of IgG glycan in natural aging and antiaging (caloric restriction (CR)) models and discovered aging-related glycans. The glycomic analysis revealed key features: downregulation of the bisected glycan GP3 (F(6)A2B) and upregulation of the digalactosylated glycan GP8 (F(6)A2G2). These glycan changes showed significant fold changes from an early stage. Using external standards of these two glycans, we subsequently measured their absolute concentrations, allowing for us to establish a predictive model, abGlycoAge, for biological aging. The abGlycoAge index suggested a younger state under CR, with an average age reduction of 3.9–14.0 weeks. Additionally, RNA sequencing of splenic B cells revealed that Derl3, Smarcb1, Ankrd55, Tbkbp1, and Slc38a10 may contribute to alterations in GP3 and GP8 during the aging process. In a preliminary therapeutic study, we tested IgG modified with young signature N-glycans (IgG-Ny). High-dose IgG-Ny showed promising results, alleviating aging-related physiological declines, including reductions in inflammatory markers and improvements in organ senescence, particularly in the brain, kidney, and lungs. This research provides new insights into glycan changes during aging and lays the groundwork for potential antiaging therapies. GP3 and GP8 may serve as biomarkers for aging, offering new perspectives on aging mechanisms and therapeutic approaches.

免疫球蛋白G (IgG) n -聚糖与衰老有关。在这项研究中，我们引入了一种发现衰老相关IgG聚糖的新策略，并建立了基于其绝对浓度变化的预测模型。我们采用糖糖定量技术鉴定了自然衰老和抗衰老（热量限制（CR））模型中IgG聚糖的数量变化，并发现了与衰老相关的聚糖。糖糖分析揭示了关键特征：分切聚糖GP3 （F(6)A2B）下调，双半乳糖化聚糖GP8 （F(6)A2G2）上调。这些聚糖变化从早期就表现出明显的褶皱变化。利用这两种聚糖的外部标准，我们随后测量了它们的绝对浓度，使我们能够建立一个预测模型，abGlycoAge，用于生物老化。CR下abGlycoAge指数呈年轻化状态，平均年龄降低3.9 ~ 14周。此外，脾B细胞的RNA测序显示，在衰老过程中，Derl3、Smarcb1、Ankrd55、Tbkbp1和Slc38a10可能导致GP3和GP8的改变。在初步的治疗研究中，我们检测了用年轻特征n -聚糖修饰的IgG （IgG- ny）。高剂量IgG-Ny显示出令人满意的结果，减轻了与衰老相关的生理衰退，包括炎症标志物的减少和器官衰老的改善，特别是在脑、肾和肺中。这项研究为衰老过程中多糖的变化提供了新的见解，并为潜在的抗衰老疗法奠定了基础。GP3和GP8可能作为衰老的生物标志物，为研究衰老机制和治疗方法提供了新的视角。

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引用次数: 0

Optimizing Cholesterol Management Strategies Based on Cholesterol–Mortality Associations 基于胆固醇-死亡率关联的胆固醇管理策略优化

IF 11.6 1区工程技术 Q1 ENGINEERING, MULTIDISCIPLINARY

Engineering

Pub Date : 2026-02-01 Epub Date: 2025-10-17 DOI: 10.1016/j.eng.2025.10.004

Jianxin Li, Xiangfeng Lu

引用次数: 0

Ablation of ST6Gal-I Downregulates BACE1 Expression and Suppresses Production of Aβ42 Plaques in Alzheimer’s Disease ST6Gal-I的消融下调阿尔茨海默病中BACE1的表达并抑制Aβ42斑块的产生

IF 11.6 1区工程技术 Q1 ENGINEERING, MULTIDISCIPLINARY

Engineering

Pub Date : 2026-02-01 Epub Date: 2025-03-07 DOI: 10.1016/j.eng.2025.02.016

Kangkang Yang , Xueying Li , Minchao Lai , Weiwei Zhao , Wanli Song , Shaobin Chen , Wenzhe Li

Recent studies indicate the involvement of glycosylation in the pathogenesis of Alzheimer’s disease (AD). α2,6-Sialylation, catalyzed by α2,6-sialyltransferase-I (ST6Gal-I), corresponds to the development of the infant brain and nervous system, however the mechanism of aberrant α2,6-sialylation affects multiple physiological and pathological conditions remains unclear. The present study, in vitro and in vivo, showed that expression of ST6Gal-I and α2,6-sialylation levels were up-regulated in cerebrospinal fluid and sera of AD patients. In addition, levels of α2,6-sialylation were also increased in brain and sera of AD model mice. Furthermore, deletion of ST6Gal-I reduced β-site amyloid precursor protein cleaving enzyme 1 (BACE1) levels and alleviated the impairment of learning and memory induced by scopolamine in rats. BACE1, a hyper-sialylated protein, plays a critical role in amyloid-β₄₂ (Aβ₄₂) production. ST6Gal-I knockdown in Neuro-2a neuroblastoma cells (ST6Gal-I-KD-N2a) reduced the expression of BACE1 via promoting its ubiquitination. Deletion of ST6Gal-I suppressed amyloid precursor protein (APP) cleaved by BACE1, followed by a decrease in Aβ₄₂ production, while alleviated Aβ₄₂-induced apoptosis. This study first reveals a significant role of α2,6-sialylation in development and progression of AD, suggesting that ST6Gal-I is a novel glycan therapeutic target for AD diagnosis and treatment.

最近的研究表明糖基化参与阿尔茨海默病（AD）的发病机制。α2,6-唾液酰转移酶i （ST6Gal-I）催化的α2,6-唾液酰化反应与婴儿大脑和神经系统的发育有关，但α2,6-唾液酰化异常影响多种生理病理状况的机制尚不清楚。本研究通过体外和体内实验发现，AD患者脑脊液和血清中ST6Gal-I和α2,6-唾液化水平表达上调。此外，α2,6-唾液酰化在AD模型小鼠脑和血清中的水平也升高。此外，st6gal - 1的缺失降低了β-位点淀粉样蛋白前体蛋白切割酶1 （BACE1）的水平，减轻了东莨菪碱对大鼠学习记忆的损害。BACE1是一种高唾液化蛋白，在淀粉样蛋白-β42 （a -β42）的产生中起关键作用。neuro2a神经母细胞瘤细胞（ST6Gal-I- kd - n2a）中ST6Gal-I的下调通过促进BACE1的泛素化来降低BACE1的表达。ST6Gal-I的缺失抑制了BACE1切割淀粉样蛋白前体蛋白（APP），导致a β42的产生减少，同时减轻了a β42诱导的细胞凋亡。本研究首次揭示了α2,6-唾液酰化在AD发生进展中的重要作用，提示ST6Gal-I是AD诊断和治疗的一个新的糖基治疗靶点。

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引用次数: 0

Glycomedicine: Unveiling the Paracentral Dogma 糖医学：揭示中心旁教条

IF 11.6 1区工程技术 Q1 ENGINEERING, MULTIDISCIPLINARY

Engineering

Pub Date : 2026-02-01 Epub Date: 2025-12-27 DOI: 10.1016/j.eng.2025.12.021

Wei Wang , Gordan Lauc

引用次数: 0

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