Food Science and Human Wellness最新文献_第7页

Maternal dietary patterns associated with bone density in Chinese lactating women and infants at 6 months postpartum: a prospective study using data from 2018–2019 母亲膳食模式与中国哺乳期妇女和产后6个月婴儿骨密度的相关性：利用2018-2019年数据进行的前瞻性研究

IF 5.6 1区农林科学 Q1 FOOD SCIENCE & TECHNOLOGY

Food Science and Human Wellness

Pub Date : 2024-09-01 DOI: 10.26599/FSHW.2022.9250214

This cohort study was designed to explore the relationship between maternal dietary patterns (DPs) and bone health in Chinese lactating mothers and infants. We recruited 150 lactating women at 1-month postpartum. The estimated bone mineral density (eBMD) of subjects’ calcanei and the information on dietary intake were collected. After 5-month follow-up, the eBMD of mothers and their infants were measured again. Factor analysis was applied to determine maternal DPs. General linear models were used to evaluate the association between maternal DPs and maternal eBMD loss or infants’ eBMD. With all potential covariates adjusted, Factor 2 (high intake of whole grains, tubers, mixed beans, soybeans and soybean products, seaweeds, and nuts) showed a positive association with the changes of maternal eBMD (β = 0.16, 95 % CI: 0.005, 0.310). Factor 3 (high intake of soft drinks, fried foods, and puffed foods) was inversely correlated with the changes of maternal eBMD (β = –0. 22, 95 % CI: -0.44, 0.00). The changes of maternal eBMD were positively associated with 6-month infants’ eBMD (β = 0.34, 95 % CI: 0.017, 0.652). In conclusion, Factor 2 might contribute to the maintenance of eBMD in lactating women, while Factor 3 could exacerbate maternal eBMD loss. Additionally, the changes of maternal eBMD presented a positive correlation with 6-month infants’ eBMD.

这项队列研究旨在探讨中国哺乳期母婴的母亲膳食模式（DPs）与骨骼健康之间的关系。我们招募了 150 名产后 1 个月的哺乳期妇女。我们收集了受试者钙骨的估计骨矿物质密度（eBMD）和膳食摄入信息。随访 5 个月后，再次测量母亲及其婴儿的 eBMD。采用因子分析来确定母亲的DP。一般线性模型用于评估母体DP与母体eBMD损失或婴儿eBMD之间的关系。在调整了所有潜在的协变量后，因子 2（全谷物、块茎类、杂豆、大豆和大豆制品、海藻类和坚果的高摄入量）与母体 eBMD 的变化呈正相关（β = 0.16，95 % CI：0.005，0.310）。因子 3（软饮料、油炸食品和膨化食品的高摄入量）与产妇 eBMD 的变化呈反向关系（β = -0.22，95 % CI：-0.44，0.00）。母体 eBMD 的变化与 6 个月婴儿的 eBMD 呈正相关（β = 0.34，95 % CI：0.017，0.652）。总之，因子 2 可能有助于维持哺乳期妇女的 eBMD，而因子 3 则可能加剧母体 eBMD 的损失。此外，母体 eBMD 的变化与 6 个月婴儿的 eBMD 呈正相关。

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引用次数: 0

Effects of a xylitol-casein complex on insulin resistance and gut microbiota composition in high-fat-diet + streptozotocin-induced type 2 diabetes mellitus mice 木糖醇-酪蛋白复合物对高脂饮食+链脲佐菌素诱导的 2 型糖尿病小鼠胰岛素抵抗和肠道微生物群组成的影响

IF 5.6 1区农林科学 Q1 FOOD SCIENCE & TECHNOLOGY

Food Science and Human Wellness

Pub Date : 2024-09-01 DOI: 10.26599/FSHW.2022.9250221

This study investigated the effects of a xylitol-casein non-covalent complex (XC) on parameters related to type 2 diabetes mellitus (T2DM), in addition to related changes in gut microbiome composition and functions. High-fat-diet (HFD) + streptozotocin (STZ)-induced T2DM mice were treated with xylitol (XY), casein (CN), and XC, after which fecal samples were collected for gut microbiota composition and diversity analyses based on 16S rRNA high-throughput sequencing and multivariate statistics. XC decreased body weight and improved glucose tolerance, insulin sensitivity, pancreas impairment, blood lipid levels, and liver function in T2DM mice compared to XY- and CN-treated mice. Furthermore, XC modulated the α-diversity, β-diversity and gut microbiota composition. Based on Spearman’s correlation analysis, the relative abundances of Alistipes, Bacteroides, and Faecalibaculum were positively correlated and those of Akkermansia, Lactobacillus, Bifidobacterium, and Turicibacter were negatively correlated with the phenotypes related to the improvement of T2DM. In conclusion, we found that XC alleviated insulin resistance by restoring the gut microbiota of T2DM mice. Our results provide strong evidence for the beneficial effects of XC on T2DM and motivation for further investigation in animal models and, eventually, human trials.

本研究调查了木糖醇-酪蛋白非共价复合物（XC）对2型糖尿病（T2DM）相关参数的影响，以及肠道微生物组组成和功能的相关变化。用木糖醇（XY）、酪蛋白（CN）和XC治疗高脂饮食（HFD）+链脲佐菌素（STZ）诱导的T2DM小鼠，然后收集粪便样本，根据16S rRNA高通量测序和多元统计分析肠道微生物群的组成和多样性。与 XY 和 CN 处理的小鼠相比，XC 降低了 T2DM 小鼠的体重，改善了葡萄糖耐量、胰岛素敏感性、胰腺损伤、血脂水平和肝功能。此外，XC 还能调节α-多样性、β-多样性和肠道微生物群的组成。根据斯皮尔曼相关分析，Alistipes、Bacteroides和Faecalibaculum的相对丰度与T2DM改善相关的表型呈正相关，而Akkermansia、乳酸杆菌、双歧杆菌和Toricibacter的相对丰度与T2DM改善相关的表型呈负相关。总之，我们发现 XC 通过恢复 T2DM 小鼠的肠道微生物群缓解了胰岛素抵抗。我们的研究结果为 XC 对 T2DM 的有益作用提供了强有力的证据，也为在动物模型中进行进一步研究以及最终进行人体试验提供了动力。

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引用次数: 0

Improvement of glucose metabolism in middle-aged mice on a high-fat diet by whole-grain highland barley is related to low methionine levels 全麦高原大麦对高脂饮食中年小鼠糖代谢的改善与低蛋氨酸水平有关

IF 5.6 1区农林科学 Q1 FOOD SCIENCE & TECHNOLOGY

Food Science and Human Wellness

Pub Date : 2024-09-01 DOI: 10.26599/FSHW.2022.9250235

Methionine restriction (MR) is an effective dietary strategy to regulate energy metabolism and alleviate oxidative stress and inflammation in the body, especially in the middle-aged and elderly population. However, the high methionine content of meat products makes this dietary strategy impossible to combine with protein supplementation and MR. Highland barley (HB), a low-methionine cereal, not only provides the body with protein but also has improved glucose metabolism and antioxidant and anti-inflammatory properties. Therefore, this study evaluated the feasibility of HB as a source of methionine-restricted dietary protein and the potential mechanisms. Middle-aged C57BL/6J mice were fed a control diet (CON), a high-fat diet (HFD), a whole-grain HB high-fat diet (HBHF), or a HBHF + methionine diet (HBHFmet) for 25 weeks. The results showed that the HBHF could keep the body weight, fasting glucose, insulin, homeostasis model assessment of insulin resistance (HOMA-IR), blood lipids, inflammation, and oxidative stress of HFD mice at normal levels. Compared with the HFD groups, HBHF inhibited pancreatic cell apoptosis and improved insulin secretion while improving hepatic and skeletal muscle glucose metabolism. However, these efficacies were attenuated in HBHFmet group mice. These findings suggest that HBHF has an MR strategy.

限制蛋氨酸摄入（MR）是一种有效的膳食策略，可调节能量代谢，缓解体内氧化应激和炎症，尤其适用于中老年人群。然而，由于肉制品中蛋氨酸含量较高，因此这种饮食策略无法与补充蛋白质和MR相结合。高地大麦（HB）是一种低蛋氨酸谷物，不仅能为人体提供蛋白质，还能改善葡萄糖代谢，具有抗氧化和抗炎特性。因此，本研究评估了 HB 作为蛋氨酸限制膳食蛋白质来源的可行性及其潜在机制。研究人员给中年 C57BL/6J 小鼠喂食对照组饮食（CON）、高脂饮食（HFD）、全谷物 HB 高脂饮食（HBHF）或 HBHF + 蛋氨酸饮食（HBHFmet）25 周。结果显示，HBHF能使HFD小鼠的体重、空腹血糖、胰岛素、胰岛素抵抗平衡模型评估（HOMA-IR）、血脂、炎症和氧化应激保持在正常水平。与高脂饮食组相比，HBHF能抑制胰腺细胞凋亡，改善胰岛素分泌，同时改善肝脏和骨骼肌的葡萄糖代谢。然而，这些功效在 HBHFmet 组小鼠中有所减弱。这些研究结果表明，HBHF 具有一种 MR 策略。

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引用次数: 0

Effects of salt and rice flour concentration on microbial diversity and the quality of sour meat, a Chinese traditional meat 盐和米粉浓度对中国传统肉类--酸肉的微生物多样性和质量的影响

IF 5.6 1区农林科学 Q1 FOOD SCIENCE & TECHNOLOGY

Food Science and Human Wellness

Pub Date : 2024-09-01 DOI: 10.26599/FSHW.2022.9250226

This study investigated the effects of salt (3 % and 6 %, m/m) and rice flour (10 % and 20 %, m/m) addition in sour meat, a traditional Chinese fermented meat. It was found that salt has greater effect than rice flour addition in spontaneous fermentation. Low-salt groups had lower pH and higher titratable total acid. In the low-salt groups, the dominant genera were Lactobacillus and Lactococcus, whereas Staphylococcus, Weissella, and Tetragenococcus were dominant in the high-salt groups. Higher total free amino acids and essential amino acids, organic acids, hexanoic acid ethyl ester and octanoic acid ethyl ester were found in the low-salt groups. The RDA analysis revealed that Lactococcus was closely related to product quality, with the S3F10 (3 % salt and 10 % rice flour) group outperforming the others in the sensory evaluation. Therefore, 3 % salt and 10 % rice flour were considered more appropriate for the production of healthy and tasty fermented sour meats.

本研究调查了在中国传统发酵肉类酸肉中添加盐（3 % 和 6 %，m/m）和米粉（10 % 和 20 %，m/m）的效果。研究发现，在自发发酵过程中，食盐的作用大于米粉。低盐组的 pH 值较低，可滴定总酸较高。低盐组的优势菌属是乳酸杆菌和乳球菌，而高盐组的优势菌属是葡萄球菌、魏氏菌和四源球菌。低盐组中游离氨基酸和必需氨基酸总量、有机酸、己酸乙酯和辛酸乙酯含量较高。RDA 分析表明，乳球菌与产品质量密切相关，S3F10（3 % 盐和 10 % 米粉）组在感官评价中优于其他组。因此，3 % 盐和 10 % 米粉被认为更适合用于生产健康美味的发酵酸肉。

引用次数: 0

Sulforaphane ameliorates non-alcoholic steatohepatitis by KLF4-mediated macrophage M2 polarization 绿藻素通过 KLF4 介导的巨噬细胞 M2 极化改善非酒精性脂肪性肝炎

IF 5.6 1区农林科学 Q1 FOOD SCIENCE & TECHNOLOGY

Food Science and Human Wellness

Pub Date : 2024-09-01 DOI: 10.26599/FSHW.2022.9250220

Non-alcoholic fatty liver disease (NAFLD) has become a global issue and a severe threat to public health. However, to date, no approved therapeutic drugs have been developed. Dietary interventions with natural products have shown promise in preventing and treating NAFLD. Sulforaphane (SFN) is a phytocompound with antioxidant and anti-inflammatory properties, and previous research has demonstrated that SFN can ameliorate hepatic lipid accumulation and inflammation. However, the molecular mechanisms underlying these beneficial effects remain unclear. In this study, we confirmed the protective effects of SFN on excessive lipid accumulation and inflammatory injury in a high-fat, high-fructose diet-induced non-alcoholic steatohepatitis (NASH) mouse model. We found that SFN attenuates the inflammatory injury in a macrophage cell line and the liver of NASH mice, owing to the promotion of M1-type macrophage polarization toward the M2-type and the regulation of inflammatory mediators. Further analysis demonstrated that this SFN-induced macrophage M2-type polarization occurs in a Krüppel-like factor 4 (KLF4)-dependent manner. In summary, we uncovered a new mechanism of action underlying SFN activity and provide evidence that dietary intervention with SFN might be protective against NASH.

非酒精性脂肪肝（NAFLD）已成为一个全球性问题，对公众健康构成严重威胁。然而，迄今为止，尚未开发出任何获得批准的治疗药物。利用天然产品进行膳食干预已显示出预防和治疗非酒精性脂肪肝的前景。红豆杉（SFN）是一种具有抗氧化和抗炎特性的植物化合物，以往的研究表明，红豆杉可改善肝脏脂质积累和炎症。然而，这些有益作用的分子机制仍不清楚。在本研究中，我们证实了 SFN 对高脂肪、高果糖饮食诱导的非酒精性脂肪性肝炎（NASH）小鼠模型中过度脂质积累和炎症损伤的保护作用。我们发现，SFN 可减轻巨噬细胞系和 NASH 小鼠肝脏的炎症损伤，这是由于它促进了 M1 型巨噬细胞向 M2 型极化，并调节了炎症介质。进一步的分析表明，SFN诱导的巨噬细胞M2型极化是以Krüppel样因子4（KLF4）依赖的方式发生的。总之，我们揭示了 SFN 活性的新作用机制，并提供了用 SFN 进行膳食干预可预防 NASH 的证据。

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引用次数: 0

Quercetin inhibits truncated isoform of dopamine- and cAMP-regulated phosphoprotein as adjuvant treatment for trastuzumab therapy resistance in HER2-positive breast cancer 槲皮素可抑制多巴胺和 cAMP 调节磷酸蛋白的截短异构体，作为曲妥珠单抗治疗 HER2 阳性乳腺癌耐药性的辅助疗法

IF 5.6 1区农林科学 Q1 FOOD SCIENCE & TECHNOLOGY

Food Science and Human Wellness

Pub Date : 2024-09-01 DOI: 10.26599/FSHW.2022.9250213

Trastuzumab resistance is one of the causes of poor prognosis in patients with human epidermal growth factor receptor 2 (HER2)-positive (HER2+) breast cancer (BC). The truncated isoform of dopamine- and cAMP-regulated phosphoprotein (t-DARPP) has been reported to be involved in trastuzumab therapy resistance and promoting tumor progression. To evaluate the t-DARPP expression in BC, paired tumors and surrounding normal tissues were analyzed by real-time polymerase chain reaction and confirmed higher DARPP-32 kDa family mRNA expression in HER2+ BC tumor tissues. We established 2 patient-derived xenografts (PDX) mice models to test the efficacy of trastuzumab, named model 1 (non-responder) and model 2 (responder). t-DARPP and p95-HER2 protein-protein interactions were detected in PDX tumor tissue from non-responders using Förster resonance energy transfer assays. Instead, there is no response from the responder. Furthermore, mechanistic studies using transwell and Western blot assays demonstrated that t-DARPP could upregulate epithelial-mesenchymal transition signaling proteins, enhance p95-HER2 expression and promote cell migration. We found that quercetin effectively reduced t-DARPP expression in HER2+ BC cells. In t-DARPP ShRNA-suppressed cells, quercetin synergistically enhanced trastuzumab-induced apoptotic cell death and G2/M phase arrest. In conclusion, the combination of quercetin and trastuzumab treatment by targeting t-DARPP in HER2+ BC patients has the potential as a biomarker for mitigating drug resistance.

曲妥珠单抗耐药是人类表皮生长因子受体2（HER2）阳性（HER2+）乳腺癌（BC）患者预后不良的原因之一。有报道称，多巴胺和cAMP调控磷酸蛋白（t-DARPP）的截短异构体参与了曲妥珠单抗耐药和促进肿瘤进展的过程。为了评估 t-DARPP 在 BC 中的表达，我们用实时聚合酶链反应分析了配对肿瘤和周围正常组织，结果证实在 HER2+ BC 肿瘤组织中 DARPP-32 kDa 家族 mRNA 表达较高。我们建立了两个患者衍生异种移植（PDX）小鼠模型来测试曲妥珠单抗的疗效，分别命名为模型1（无应答者）和模型2（有应答者）。相反，应答者没有任何反应。此外，利用透孔法和 Western 印迹法进行的机理研究表明，t-DARPP 可上调上皮-间质转化信号蛋白，增强 p95-HER2 的表达并促进细胞迁移。我们发现，槲皮素能有效降低 t-DARPP 在 HER2+ BC 细胞中的表达。在t-DARPP ShRNA抑制的细胞中，槲皮素能协同增强曲妥珠单抗诱导的细胞凋亡和G2/M期停滞。总之，在HER2+ BC患者中通过靶向t-DARPP联合使用槲皮素和曲妥珠单抗治疗有可能成为减轻耐药性的生物标记物。

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引用次数: 0

High β-sitosterol-D-glucoside content in sweet potato varieties and its anti-breast cancer potential through multiple metastasis-associated signals 甘薯品种中的高β-谷甾醇-D-葡萄糖苷含量及其通过多种转移相关信号抗乳腺癌的潜力

IF 5.6 1区农林科学 Q1 FOOD SCIENCE & TECHNOLOGY

Food Science and Human Wellness

Pub Date : 2024-09-01 DOI: 10.26599/FSHW.2022.9250225

β-Sitosterol-D-glucoside (β-SDG) is a phytosterol compound whose antitumor activity has been confirmed by previous studies. However, its suppression on breast cancer remains unclear. To that purpose, we isolated β-SDG from sweet potato and investigated the breast-cancer-inhibiting mechanism using proteomic analysis. The sweet potato species S6 with high β-SDG content were chosen form 36 species and β-SDG was isolated by HPLC. Afterwards, an in situ animal model of breast cancer was established, and β-SDG significantly reduced the tumor volume of MCF-7 xenograft mice. Proteomic analysis of tumor tissues revealed that 127 of these proteins were upregulated and 80 were downregulated. Gene ontology and network analysis showed that regulatory proteins were mainly associated with epithelial-mesenchymal transition (EMT), myogenesis, cholesterol homeostasis, oxidative phosphorylation and reactive oxygen pathways, while Vimentin, NDUF, VDAC1, PPP2CA and SNX9 were the most significant 5 node degree genes. Meanwhile, in vitro and in vivo results showed that the protein expression of PPP2CA and Vimentin, which are markers of EMT, were involved in breast cancer cell metastasis and could be reversed by β-SDG. This work highlights β-SDG as a bioactive compound in sweet potato and the potential therapeutic effect of β-SDG for the treatment of breast cancer by inhibiting metastasis.

β-谷甾醇-D-葡萄糖苷（β-SDG）是一种植物甾醇化合物，其抗肿瘤活性已被先前的研究证实。然而，其对乳腺癌的抑制作用仍不明确。为此，我们从甘薯中分离出了β-SDG，并利用蛋白质组分析研究了其抑制乳腺癌的机制。我们从36个甘薯品种中选出了β-SDG含量较高的甘薯品种S6，并通过高效液相色谱法分离了β-SDG。随后，建立了乳腺癌原位动物模型，β-SDG能显著减少MCF-7异种移植小鼠的肿瘤体积。肿瘤组织的蛋白质组学分析表明，其中127种蛋白质上调，80种蛋白质下调。基因本体和网络分析显示，调控蛋白主要与上皮-间质转化（EMT）、肌生成、胆固醇稳态、氧化磷酸化和活性氧通路相关，而Vimentin、NDUF、VDAC1、PPP2CA和SNX9是最重要的5个节点度基因。同时，体外和体内研究结果表明，作为EMT标志物的PPP2CA和Vimentin的蛋白表达参与了乳腺癌细胞的转移，并能被β-SDG逆转。这项研究强调了β-SDG作为甘薯中的一种生物活性化合物，以及β-SDG通过抑制转移来治疗乳腺癌的潜在疗效。

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引用次数: 0

Maillard reaction affecting immunobinding activity and digestibility of tropomyosin in Alectryonella plicatula food matrix 马氏反应影响栉水母食物基质中肌球蛋白的免疫结合活性和消化率

IF 5.6 1区农林科学 Q1 FOOD SCIENCE & TECHNOLOGY

Food Science and Human Wellness

Pub Date : 2024-09-01 DOI: 10.26599/FSHW.2022.9250239

In recent years, the allergy rate of oysters has surged, and daily food processing methods make it hard to reduce heat resistance and digestive allergy such as tropomyosin (TM). In this study, the Maillard reaction with xylose (Xyl) significantly reduced the IgE binding capacity of Alectryonella plicatula food matrix (AFM), that reduced by (77.81 ± 2.68)%. The study found the Maillard reaction changes the structure of the AFM, in which the content of α-helix decreased by (24.64 ± 1.46)%. Structural transformation further explains why the Maillard reaction alters the immunobinding activity of AFM. In addition, the Maillard reaction reduces the digestive stability of the AFM and makes TM in the A. plicatula food matrix Maillard reaction products (AFM-MRPs) more easily digested. Based on the above research, 10 amino acids on the 7 IgE epitopes of TM were modified. This result indicates that the Maillard reaction reduces the immunobinding activity of the AFM by changing the structure and modifying the amino acids on the epitope.

近年来，牡蛎过敏率激增，日常食品加工方法难以降低耐热性和消化道过敏性，如滋养肌肽（TM）。在这项研究中，木糖（Xyl）的马氏反应显著降低了Alectryonella plicatula食物基质（AFM）的IgE结合能力，降低了（77.81 ± 2.68）%。研究发现，马氏反应改变了 AFM 的结构，其中 α-螺旋的含量减少了（24.64 ± 1.46）%。结构转变进一步解释了为什么马氏反应会改变 AFM 的免疫结合活性。此外，马氏反应降低了 AFM 的消化稳定性，使 A. plicatula 食物基质马氏反应产物（AFM-MRPs）中的 TM 更容易被消化。根据上述研究，TM 的 7 个 IgE 表位上有 10 个氨基酸被修饰。这一结果表明，马氏反应通过改变结构和修饰表位上的氨基酸，降低了 AFM 的免疫结合活性。

引用次数: 0

Adjuvant postbiotic administration improves dental caries prognosis by restoring the oral microbiota 通过恢复口腔微生物群，辅助使用后益生菌可改善龋齿预后

IF 5.6 1区农林科学 Q1 FOOD SCIENCE & TECHNOLOGY

Food Science and Human Wellness

Pub Date : 2024-09-01 DOI: 10.26599/FSHW.2022.9250217

Conventional filling therapy fails to fundamentally reduce oral cariogenic bacteria. Thus, oral microbiota follow-up intervention after filling would be necessary for improving dental caries prognosis. We recruited 9 caries-free individuals, and 89 dental caries subjects (5 dropouts). Eighty-nine patients were randomized into three groups: caries (n = 8; no treatment), control (n = 40; filling), and postbiotics (n = 41; filling and 14-day Probio-Eco® intervention). Salivary samples were collected at 0 day (after filling) and 14 days. Our results showed that the diversity of dental caries oral microbiota was significantly increased compared with healthy subjects, and filling could restore a healthier oral microbiota partially and temporarily. Thepostbiotics intervention keeps a low alpha-diversity. Co-occurrence network analysis showed that a more stable oral microbiota structure after postbiotics intervention. Taxonomic and functional annotation of the microbiota revealed that postbiotics co-treatment significantly: increased the relative abundance of Pseudomonas and P. reactans, decreased the relative abundance of Prevotella shahii, and enriched the energy metabolism-related pathways. BugBase-predicted phenotypes inferred to an oral microbiota with decreased potential pathogenic bacteria and increased oxidative stress-tolerant bacteria after postbiotics intervention. Collectively, it suggested that postbiotics co-treatment could be a promising strategy that restores the oral microecological balance for dental caries.

传统的充填疗法无法从根本上减少口腔致龋菌。因此，有必要在补牙后对口腔微生物群进行跟踪干预，以改善龋齿的预后。我们招募了 9 名无龋患者和 89 名龋齿患者（5 人退出）。89 名患者被随机分为三组：龋齿组（n = 8；无治疗）、对照组（n = 40；补牙）和后益生菌组（n = 41；补牙和 14 天 Probio-Eco® 干预）。在 0 天（补牙后）和 14 天收集唾液样本。我们的研究结果表明，与健康受试者相比，龋齿口腔微生物群的多样性明显增加，而补牙可以部分地、暂时地恢复更健康的口腔微生物群。后益生菌干预可保持较低的α-多样性。共现网络分析显示，后生药干预后口腔微生物群结构更加稳定。微生物群的分类和功能注释显示，联合使用益生菌后处理显著增加了假单胞菌和P. reactans的相对丰度，降低了Prevotella shahii的相对丰度，并丰富了能量代谢相关通路。根据 BugBase 预测的表型推断，口腔微生物群中潜在的致病菌减少了，耐氧化应激细菌增加了。总之，这表明益生菌后联合治疗可能是恢复龋齿口腔微生态平衡的一种有前途的策略。

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引用次数: 0

Overview on signal transduction cascades regulation roles of garlic and its bioactive constituents 大蒜及其生物活性成分的信号转导级联调控作用概述

IF 5.6 1区农林科学 Q1 FOOD SCIENCE & TECHNOLOGY

Food Science and Human Wellness

Pub Date : 2024-09-01 DOI: 10.26599/FSHW.2022.9250196

High-throughput technologies in combination with modern exciting advancements in mass spectrometry-based proteomics and data analysis pipelines have empowered comprehensive characterization of disease phenotypes and their mechanistic regulation by dietary agents and bioactive molecules at unprecedented dimensionality and resolution. Extra-ordinary breakthroughs in the field of nutrigenomics have leveraged our understanding altogether to a new level of maturity. Interdisciplinary researchers have extensively analyzed health promoting and pharmacologically significant properties of garlic (Allium sativum). Importantly, garlic and its biologically active chemicals targeted oncogenic signaling cascades. In this mini-review we have attempted to summarize how garlic and its bioactive constituents regulated signal transduction cascades in cell culture studies and tumor-bearing mice.

高通量技术与基于质谱的蛋白质组学和数据分析管道方面令人振奋的现代进步相结合，以前所未有的维度和分辨率对疾病表型及其受膳食因子和生物活性分子调控的机理进行了全面描述。营养基因组学领域的非凡突破将我们的认识提升到了一个新的成熟水平。跨学科研究人员广泛分析了大蒜（Allium sativum）促进健康和具有药理学意义的特性。重要的是，大蒜及其生物活性化学物质针对的是致癌信号级联。在这篇小型综述中，我们试图总结大蒜及其生物活性成分如何在细胞培养研究和肿瘤小鼠中调节信号转导级联。

引用次数: 0