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Nutrition-sensitive agricultural interventions and maternal and child nutrition outcomes in arid and semi-arid lands of Kenya.
IF 4 2区 农林科学 Q2 NUTRITION & DIETETICS Pub Date : 2025-02-18 eCollection Date: 2025-01-01 DOI: 10.3389/fnut.2025.1465650
Frederick K E Grant, Dorcas Amunga, Chalmers K Mulwa, Mukani Moyo, Norman Kwikiriza, Jack Malit, Lucy Mwaura, Joyce Maru, Simon Heck
<p><strong>Background: </strong>In regions facing chronic stress such as the arid and semi-arid lands (ASALs) of Kenya, there is poor quality of diet among women and children in humanitarian situations, mainly due to multiple climatic shocks that exacerbate local food systems. The objective of this study was to assess the effect of household participation in climate smart nutrition-sensitive agriculture (NSA) interventions on maternal and young child nutrition outcomes in Makueni, Garissa and Tana River counties.</p><p><strong>Methods: </strong>From March 2020 to October 2023, the International Potato Center and partners (World Food Program, Ministries of Agriculture and Health) implemented an NSA intervention in Makueni, Garissa and Tana River counties. The intervention comprised of household participating in three main activities: (1) access to orange fleshed sweetpotato (OFSP) vines; (2) participation in nutrition education activities and (3) receiving and utilizing infant feeding toolkits (Healthy Baby Toolkit/HBT). Approximately 3 months after intervention activities, we conducted a cross-sectional survey in intervention communities to assess effect of particpation in the interventions on maternal and child nutrition outcomes. The study utilized the doubly robust <i>inverse probability weighting regression adjustment</i> (IPWRA) estimator to evaluate the impact of participation in the project intervention on nutrition outcomes. Caregivers' knowledge of nutrition, health and childcare, women (MDD-W) and young child dietary diversity (MDD-C), vitamin A (VA) intakes, minimum meal frequency (MMF), and minimum acceptable diet (MAD) for children 6-23 months were analyzed. The comparison of means and proportions was assessed using Student's t-test and the Chi-square test, respectively, between the caregivers participating in NSA interventions and non-participants. The impact of the level of participation in NSA interventions and information on how to utilize these to improve infant and maternal feeding in the household on caregiver knowledge and practices scores was examined using regression analysis.</p><p><strong>Results: </strong>Of 494 caregivers surveyed, 72% indicated to have participated in at least one study intervention. In adjusted analyses, participation in at least one of the study interventions was significantly associated with improved caregiver nutrition [<i>β</i>: 0.943, <i>p</i> < 0.05], and VA [0.613, <i>p</i> < 0.05] knowledge scores and young child MMF [0.202, <i>p</i> < 0.05] and MAD [0.111, <i>p</i> < 0.05]. Participation in all three interventions (nutrition training, use of infant feeding toolkit and access to OFSP vines) significantly increased VA knowledge among caregivers (<i>p</i> ≤ 0.05) and infant MMF (<i>p</i> ≤ 0.05). While the use of infant feeding toolkit and access to OFSP vines alone had a significant positive effect on MDD-W and MDD-C (<i>p</i> ≤ 0.05).</p><p><strong>Conclusion: </strong>The findings show the ne
{"title":"Nutrition-sensitive agricultural interventions and maternal and child nutrition outcomes in arid and semi-arid lands of Kenya.","authors":"Frederick K E Grant, Dorcas Amunga, Chalmers K Mulwa, Mukani Moyo, Norman Kwikiriza, Jack Malit, Lucy Mwaura, Joyce Maru, Simon Heck","doi":"10.3389/fnut.2025.1465650","DOIUrl":"10.3389/fnut.2025.1465650","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;In regions facing chronic stress such as the arid and semi-arid lands (ASALs) of Kenya, there is poor quality of diet among women and children in humanitarian situations, mainly due to multiple climatic shocks that exacerbate local food systems. The objective of this study was to assess the effect of household participation in climate smart nutrition-sensitive agriculture (NSA) interventions on maternal and young child nutrition outcomes in Makueni, Garissa and Tana River counties.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;From March 2020 to October 2023, the International Potato Center and partners (World Food Program, Ministries of Agriculture and Health) implemented an NSA intervention in Makueni, Garissa and Tana River counties. The intervention comprised of household participating in three main activities: (1) access to orange fleshed sweetpotato (OFSP) vines; (2) participation in nutrition education activities and (3) receiving and utilizing infant feeding toolkits (Healthy Baby Toolkit/HBT). Approximately 3 months after intervention activities, we conducted a cross-sectional survey in intervention communities to assess effect of particpation in the interventions on maternal and child nutrition outcomes. The study utilized the doubly robust &lt;i&gt;inverse probability weighting regression adjustment&lt;/i&gt; (IPWRA) estimator to evaluate the impact of participation in the project intervention on nutrition outcomes. Caregivers' knowledge of nutrition, health and childcare, women (MDD-W) and young child dietary diversity (MDD-C), vitamin A (VA) intakes, minimum meal frequency (MMF), and minimum acceptable diet (MAD) for children 6-23 months were analyzed. The comparison of means and proportions was assessed using Student's t-test and the Chi-square test, respectively, between the caregivers participating in NSA interventions and non-participants. The impact of the level of participation in NSA interventions and information on how to utilize these to improve infant and maternal feeding in the household on caregiver knowledge and practices scores was examined using regression analysis.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Of 494 caregivers surveyed, 72% indicated to have participated in at least one study intervention. In adjusted analyses, participation in at least one of the study interventions was significantly associated with improved caregiver nutrition [&lt;i&gt;β&lt;/i&gt;: 0.943, &lt;i&gt;p&lt;/i&gt; &lt; 0.05], and VA [0.613, &lt;i&gt;p&lt;/i&gt; &lt; 0.05] knowledge scores and young child MMF [0.202, &lt;i&gt;p&lt;/i&gt; &lt; 0.05] and MAD [0.111, &lt;i&gt;p&lt;/i&gt; &lt; 0.05]. Participation in all three interventions (nutrition training, use of infant feeding toolkit and access to OFSP vines) significantly increased VA knowledge among caregivers (&lt;i&gt;p&lt;/i&gt; ≤ 0.05) and infant MMF (&lt;i&gt;p&lt;/i&gt; ≤ 0.05). While the use of infant feeding toolkit and access to OFSP vines alone had a significant positive effect on MDD-W and MDD-C (&lt;i&gt;p&lt;/i&gt; ≤ 0.05).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;The findings show the ne","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1465650"},"PeriodicalIF":4.0,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11876023/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biochemical and agro-morphological traits-based mining for Malt Barley Germplasm.
IF 4 2区 农林科学 Q2 NUTRITION & DIETETICS Pub Date : 2025-02-18 eCollection Date: 2025-01-01 DOI: 10.3389/fnut.2025.1480708
Shakti Khera, Prakash Kumar, Shashi Bhushan Tripathi, Sherry Racheal Jacob, Dinesh Kumar, Charan Singh, Rakesh Bhardwaj, Sudhir Pal Ahlawat, Jai Chand Rana, Amritbir Riar

Barley serves as a crucial feed crop and is also utilized for baking, malting, and brewing purposes. In India, the consistent demand for malting-type barley has not been met due to the lack of suitable varieties. This study evaluated 136 barley germplasm accessions for diversity in biochemical and agro-morphological traits. The accessions were grown in Augmented Block Design and biochemical estimations were carried out using official and standard methods. The accessions exhibited substantial biochemical diversity with protein content (PC) ranging from 8.6 to 17.4%, starch content (SC) from 32.4 to 60.3%, amylose content (AC) from 13.3 to 19.3%, β-glucan content (βgC) from 1.31 to 6.06%, and total phenol content (TPC) from 8.6 to 17.4%. The agro-morphological traits also displayed considerable variation, with days to spike emergence (DSE) ranging from 74 to 124 days, days to physiological maturity (DPM) from 119 to 147 days, plant height (PH) from 82 to 165 cm, spike length (SL) from 5 to 11 cm, spikelet triplet groups (STG) per spike from 13 to 35, grain number per spike (GNS) from 15 to 71, hundred-grain weight (HGW) from 2 to 6.7 grams, and grain yield per meter row (GY) from 13.7 to 236.3 grams. Multivariate analyses, including the Mantel test, Pearson's correlation, principal component analysis (PCA), and hierarchical cluster analysis (HCA), were conducted. No significant correlation was observed between biochemical and agro-morphological traits. However, significant positive correlations were found between SC and AC (r = 0.48) and βgC with PC (r = 0.2). Significant negative correlations were observed between SC and PC (r = -0.41) and AC with PC (r = -0.4). Highly significant positive correlations were observed between DSE and DPM (r = 0.55), GY and PH (r = 0.29), PH and DPM (r = 0.2), and HGW and SL (r = 0.25). The GWL was significantly positively correlated with βgC (r = 0.257) and significantly negatively correlated with TPC (r = -0.235). Apart from Grain Width to Length Ratio (GWL), no other agro-morphological trait was significantly correlated with any biochemical trait. Various accessions suitable for malting, human food, and cattle feed applications were identified.

{"title":"Biochemical and agro-morphological traits-based mining for Malt Barley Germplasm.","authors":"Shakti Khera, Prakash Kumar, Shashi Bhushan Tripathi, Sherry Racheal Jacob, Dinesh Kumar, Charan Singh, Rakesh Bhardwaj, Sudhir Pal Ahlawat, Jai Chand Rana, Amritbir Riar","doi":"10.3389/fnut.2025.1480708","DOIUrl":"10.3389/fnut.2025.1480708","url":null,"abstract":"<p><p>Barley serves as a crucial feed crop and is also utilized for baking, malting, and brewing purposes. In India, the consistent demand for malting-type barley has not been met due to the lack of suitable varieties. This study evaluated 136 barley germplasm accessions for diversity in biochemical and agro-morphological traits. The accessions were grown in Augmented Block Design and biochemical estimations were carried out using official and standard methods. The accessions exhibited substantial biochemical diversity with protein content (PC) ranging from 8.6 to 17.4%, starch content (SC) from 32.4 to 60.3%, amylose content (AC) from 13.3 to 19.3%, <i>β</i>-glucan content (βgC) from 1.31 to 6.06%, and total phenol content (TPC) from 8.6 to 17.4%. The agro-morphological traits also displayed considerable variation, with days to spike emergence (DSE) ranging from 74 to 124 days, days to physiological maturity (DPM) from 119 to 147 days, plant height (PH) from 82 to 165 cm, spike length (SL) from 5 to 11 cm, spikelet triplet groups (STG) per spike from 13 to 35, grain number per spike (GNS) from 15 to 71, hundred-grain weight (HGW) from 2 to 6.7 grams, and grain yield per meter row (GY) from 13.7 to 236.3 grams. Multivariate analyses, including the Mantel test, Pearson's correlation, principal component analysis (PCA), and hierarchical cluster analysis (HCA), were conducted. No significant correlation was observed between biochemical and agro-morphological traits. However, significant positive correlations were found between SC and AC (<i>r</i> = 0.48) and βgC with PC (<i>r</i> = 0.2). Significant negative correlations were observed between SC and PC (<i>r</i> = -0.41) and AC with PC (<i>r</i> = -0.4). Highly significant positive correlations were observed between DSE and DPM (<i>r</i> = 0.55), GY and PH (<i>r</i> = 0.29), PH and DPM (<i>r</i> = 0.2), and HGW and SL (<i>r</i> = 0.25). The GWL was significantly positively correlated with βgC (<i>r</i> = 0.257) and significantly negatively correlated with TPC (<i>r</i> = -0.235). Apart from Grain Width to Length Ratio (GWL), no other agro-morphological trait was significantly correlated with any biochemical trait. Various accessions suitable for malting, human food, and cattle feed applications were identified.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1480708"},"PeriodicalIF":4.0,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11877615/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multi-omics revealed that the postbiotic of hawthorn-probiotic alleviated constipation caused by loperamide in elderly mice.
IF 4 2区 农林科学 Q2 NUTRITION & DIETETICS Pub Date : 2025-02-18 eCollection Date: 2025-01-01 DOI: 10.3389/fnut.2025.1498004
Yu Wei, Shuai Chen, Ying Ling, Wei Wang, Yali Huang
{"title":"Multi-omics revealed that the postbiotic of hawthorn-probiotic alleviated constipation caused by loperamide in elderly mice.","authors":"Yu Wei, Shuai Chen, Ying Ling, Wei Wang, Yali Huang","doi":"10.3389/fnut.2025.1498004","DOIUrl":"10.3389/fnut.2025.1498004","url":null,"abstract":"","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1498004"},"PeriodicalIF":4.0,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11895004/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Successful application of dietary ketogenic metabolic therapy in patients with glioblastoma: a clinical study.
IF 4 2区 农林科学 Q2 NUTRITION & DIETETICS Pub Date : 2025-02-18 eCollection Date: 2024-01-01 DOI: 10.3389/fnut.2024.1489812
Andreas Kiryttopoulos, Athanasios E Evangeliou, Irene Katsanika, Ioannis Boukovinas, Nikolaos Foroglou, Basilios Zountsas, Angeliki Cheva, Vaios Nikolopoulos, Thomas Zaramboukas, Tomas Duraj, Thomas N Seyfried, Martha Spilioti

Introduction: Glioblastoma multiforme (GBM) ranks as one of the most aggressive primary malignant tumor affecting the brain. The persistent challenge of treatment failure and high relapse rates in GBM highlights the need for new treatment approaches. Recent research has pivoted toward exploring alternative therapeutic methods, such as the ketogenic diet, for GBM.

Methods: A total of 18 patients with GBM, 8 women and 10 men, aged between 34 and 75 years participated in a prospective study, examining the impact of ketogenic diet on tumor progression. The pool of patients originated from our hospital during the period from January 2016 until July 2021 and were followed until January 2024. As an assessment criterion, we set an optimistic target for adherence to the ketogenic diet beyond 6 months. We considered the therapeutic combination successful if the survival reached at least 3 years.

Results: Among the 18 patients participating in the study, 6 adhered to the ketogenic diet for more than 6 months. Of these patients, one patient passed away 43 months after diagnosis, achieving a survival of 3 years; another passed away at 36 months, narrowly missing the 3-year survival mark; and one is still alive at 33 months post-diagnosis but has yet to reach the 3-year milestone and is, therefore, not included in the final survival rate calculation. The remaining 3 are also still alive, completing 84,43 and 44 months of life, respectively. Consequently, the survival rate among these patients is 4 out of 6, or 66.7%. Of the 12 patients who did not adhere to the diet, only one reached 36 months of survival, while the rest have died in an average time of 15.7 ± 6.7 months, with a 3-year survival rate of 8.3%. Comparing the survival rates of the two groups, we see that the difference is 58.3% (66.7% versus 8.3%) and is statistically significant with p < 0.05 (0.0114) and X2 = 6.409.

Discussion: The outcomes observed in these patients offer promising insights into the potential benefits of the ketogenic diet on the progression of glioblastoma multiforme when compared to those who did not follow the diet consistently.

{"title":"Successful application of dietary ketogenic metabolic therapy in patients with glioblastoma: a clinical study.","authors":"Andreas Kiryttopoulos, Athanasios E Evangeliou, Irene Katsanika, Ioannis Boukovinas, Nikolaos Foroglou, Basilios Zountsas, Angeliki Cheva, Vaios Nikolopoulos, Thomas Zaramboukas, Tomas Duraj, Thomas N Seyfried, Martha Spilioti","doi":"10.3389/fnut.2024.1489812","DOIUrl":"10.3389/fnut.2024.1489812","url":null,"abstract":"<p><strong>Introduction: </strong>Glioblastoma multiforme (GBM) ranks as one of the most aggressive primary malignant tumor affecting the brain. The persistent challenge of treatment failure and high relapse rates in GBM highlights the need for new treatment approaches. Recent research has pivoted toward exploring alternative therapeutic methods, such as the ketogenic diet, for GBM.</p><p><strong>Methods: </strong>A total of 18 patients with GBM, 8 women and 10 men, aged between 34 and 75 years participated in a prospective study, examining the impact of ketogenic diet on tumor progression. The pool of patients originated from our hospital during the period from January 2016 until July 2021 and were followed until January 2024. As an assessment criterion, we set an optimistic target for adherence to the ketogenic diet beyond 6 months. We considered the therapeutic combination successful if the survival reached at least 3 years.</p><p><strong>Results: </strong>Among the 18 patients participating in the study, 6 adhered to the ketogenic diet for more than 6 months. Of these patients, one patient passed away 43 months after diagnosis, achieving a survival of 3 years; another passed away at 36 months, narrowly missing the 3-year survival mark; and one is still alive at 33 months post-diagnosis but has yet to reach the 3-year milestone and is, therefore, not included in the final survival rate calculation. The remaining 3 are also still alive, completing 84,43 and 44 months of life, respectively. Consequently, the survival rate among these patients is 4 out of 6, or 66.7%. Of the 12 patients who did not adhere to the diet, only one reached 36 months of survival, while the rest have died in an average time of 15.7 ± 6.7 months, with a 3-year survival rate of 8.3%. Comparing the survival rates of the two groups, we see that the difference is 58.3% (66.7% versus 8.3%) and is statistically significant with <i>p</i> < 0.05 (0.0114) and X<sup>2</sup> = 6.409.</p><p><strong>Discussion: </strong>The outcomes observed in these patients offer promising insights into the potential benefits of the ketogenic diet on the progression of glioblastoma multiforme when compared to those who did not follow the diet consistently.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"11 ","pages":"1489812"},"PeriodicalIF":4.0,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11876051/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between constipation and the urine albumin-to-creatinine ratio in adults: the NHANES 2009-2010.
IF 4 2区 农林科学 Q2 NUTRITION & DIETETICS Pub Date : 2025-02-17 eCollection Date: 2025-01-01 DOI: 10.3389/fnut.2025.1477148
Yuying Yang, Siyi Rao, Yongjie Zhuo, Yuan Fang, Jianxin Wan, Danyu You

Objective: This study aimed to analyze the association between constipation and the urine albumin-to-creatinine ratio (ACR) using data from the National Health and Nutrition Examination Survey (NHANES) 2009-2010.

Methods: In this cross-sectional study, a sample of 4,282 adults aged 20 and older was selected from the NHANES 2009-2010. Constipation was defined as having fewer than three bowel movements per week. The average of the two ACR measurements was used as the outcome variable. Logistic regression models (non-adjusted and multivariate adjusted models) were used to examine the relationship between constipation and ACR. Subgroup and interaction analyses related to gender, age, smoking, alcohol consumption, body mass index (BMI), hypertension, and diabetes were also conducted to assess the stability of the association between constipation and ACR.

Results: In this study population of 4,282 individuals, 352 individuals with an ACR of 30 mg/g or higher were considered to have albuminuria. The prevalence of constipation was higher in the albuminuria group compared to the non-albuminuric group (6.4% vs. 3.5%, p = 0.002). The unadjusted model (Model I) showed an increased risk of ACR associated with constipation (OR 1.81, 95% CI 1.13-2.91, p = 0.014). After controlling for gender, age, race/ethnicity, marital status, and education level in Model II, the association between constipation and ACR remained significant (OR 2.20, 95% CI 1.34-3.60, p = 0.002). Upon further adjustment for BMI, smoking status, alcohol consumption, diabetes, hypertension, arthritis, asthma, coronary heart disease, liver disease, cancer, blood urea nitrogen (BUN), serum creatinine (Scr), uric acid (UA) and estimated glomerular filtration rate (eGFR) in Model III, the positive association between constipation and ACR was still significant (OR 1.88, 95% CI 1.09-3.23, p = 0.023). Subgroup analyses, stratified by gender, age, smoking status, alcohol consumption, BMI, hypertension, and diabetes, showed no statistically significant interactions (p > 0.05).

Conclusion: In summary, this study found a positive association between constipation and urinary albumin excretion rate. The significant association between constipation and ACR highlights the need for clinicians to monitor urinary albumin levels in patients with constipation.

{"title":"Association between constipation and the urine albumin-to-creatinine ratio in adults: the NHANES 2009-2010.","authors":"Yuying Yang, Siyi Rao, Yongjie Zhuo, Yuan Fang, Jianxin Wan, Danyu You","doi":"10.3389/fnut.2025.1477148","DOIUrl":"10.3389/fnut.2025.1477148","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to analyze the association between constipation and the urine albumin-to-creatinine ratio (ACR) using data from the National Health and Nutrition Examination Survey (NHANES) 2009-2010.</p><p><strong>Methods: </strong>In this cross-sectional study, a sample of 4,282 adults aged 20 and older was selected from the NHANES 2009-2010. Constipation was defined as having fewer than three bowel movements per week. The average of the two ACR measurements was used as the outcome variable. Logistic regression models (non-adjusted and multivariate adjusted models) were used to examine the relationship between constipation and ACR. Subgroup and interaction analyses related to gender, age, smoking, alcohol consumption, body mass index (BMI), hypertension, and diabetes were also conducted to assess the stability of the association between constipation and ACR.</p><p><strong>Results: </strong>In this study population of 4,282 individuals, 352 individuals with an ACR of 30 mg/g or higher were considered to have albuminuria. The prevalence of constipation was higher in the albuminuria group compared to the non-albuminuric group (6.4% vs. 3.5%, <i>p</i> = 0.002). The unadjusted model (Model I) showed an increased risk of ACR associated with constipation (OR 1.81, 95% CI 1.13-2.91, <i>p</i> = 0.014). After controlling for gender, age, race/ethnicity, marital status, and education level in Model II, the association between constipation and ACR remained significant (OR 2.20, 95% CI 1.34-3.60, <i>p</i> = 0.002). Upon further adjustment for BMI, smoking status, alcohol consumption, diabetes, hypertension, arthritis, asthma, coronary heart disease, liver disease, cancer, blood urea nitrogen (BUN), serum creatinine (Scr), uric acid (UA) and estimated glomerular filtration rate (eGFR) in Model III, the positive association between constipation and ACR was still significant (OR 1.88, 95% CI 1.09-3.23, <i>p</i> = 0.023). Subgroup analyses, stratified by gender, age, smoking status, alcohol consumption, BMI, hypertension, and diabetes, showed no statistically significant interactions (<i>p</i> > 0.05).</p><p><strong>Conclusion: </strong>In summary, this study found a positive association between constipation and urinary albumin excretion rate. The significant association between constipation and ACR highlights the need for clinicians to monitor urinary albumin levels in patients with constipation.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1477148"},"PeriodicalIF":4.0,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11872728/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrigendum: The effects of creatine supplementation on cognitive function in adults: a systematic review and meta-analysis.
IF 4 2区 农林科学 Q2 NUTRITION & DIETETICS Pub Date : 2025-02-17 eCollection Date: 2025-01-01 DOI: 10.3389/fnut.2025.1570800
Chen Xu, Siyuan Bi, Wenxin Zhang, Lin Luo

[This corrects the article DOI: 10.3389/fnut.2024.1424972.].

{"title":"Corrigendum: The effects of creatine supplementation on cognitive function in adults: a systematic review and meta-analysis.","authors":"Chen Xu, Siyuan Bi, Wenxin Zhang, Lin Luo","doi":"10.3389/fnut.2025.1570800","DOIUrl":"https://doi.org/10.3389/fnut.2025.1570800","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/fnut.2024.1424972.].</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1570800"},"PeriodicalIF":4.0,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11873458/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of dietary intake of saturated fatty acids with obstructive sleep apnea: mediating effects of Life's Crucial 9.
IF 4 2区 农林科学 Q2 NUTRITION & DIETETICS Pub Date : 2025-02-17 eCollection Date: 2025-01-01 DOI: 10.3389/fnut.2025.1503815
Ruoyu Gou, Lili Chen, Zeyi Cheng, Jiawei Cun, Guanghua Li

Introduction: Obstructive sleep apnea (OSA) is a global public health issue. Life's Crucial 9 (LC9) is recognized as a powerful tool for assessing cardiovascular health. Although the etiology of OSA remains unclear, saturated fatty acids (SFAs) and cardiovascular health are increasingly regarded as a non-negligible element. This study aims to assess the association between dietary intake of SFAs and the risk of OSA, and the mediating effect of LC9.

Methods: Based on the National Health and Nutrition Examination Survey (NHANES), dietary questionnaires of participant were collected, and the average values of 24-h dietary recall data over 2 days were obtained. A continuous cross-sectional analysis with dietary energy adjustment was employed. Weighted multivariable logistic regression models were used to estimate the weighted odds ratios (ORs) and their 95% confidence intervals (CIs) for SFAs and OSA. Evaluate the mediating role of LC9 in the relationship between SFAs and OSA.

Results: A total of 13,563 participants aged 20 years and above were included in this study. The intakes of Sfa 4.0 and LC9 among participants with OSA were significantly lower than those in the normal population. After adjusting for confounding factors, total SFAs could increase the risk of OSA [Model 1, Q3, 0.03, 1.49 (1.03, 2.15); Model 2, Q3, 0.04, 1.47 (1.01, 2.13)]. It was emphasized that dietary intake of Sfa 12.0, Sfa 14.0, and Sfa 16.0 were protective factors for OSA, especially among participants aged 45-64 years and white individuals. Moreover, Sfa 12.0 exhibited a better protective effect in female participants [Q3, 0.04, 0.66 (0.45, 0.99)]. In addition, the cardiovascular health score - LC9 had a mediating effect in Sfa4.0 on OSA [Proportion of mediation: -0.035, 95% CI: (-0.058, -0.01); p= 0.002]. There was a nonlinear relationship between dietary intake of Sfa 12.0, Sfa 16.0, and Sfa 18.0 and OSA (P-Nonlinear = 0.013).

Discussion: These findings suggest that dietary mixtures of saturated fatty acids increase the risk of OSA. Among them, SFA 4:0 can increase the risk of OSA through the level of cardiovascular health. However, contrary to traditional beliefs, long-chain saturated fatty acids can reduce the risk of OSA.

{"title":"Association of dietary intake of saturated fatty acids with obstructive sleep apnea: mediating effects of Life's Crucial 9.","authors":"Ruoyu Gou, Lili Chen, Zeyi Cheng, Jiawei Cun, Guanghua Li","doi":"10.3389/fnut.2025.1503815","DOIUrl":"10.3389/fnut.2025.1503815","url":null,"abstract":"<p><strong>Introduction: </strong>Obstructive sleep apnea (OSA) is a global public health issue. Life's Crucial 9 (LC9) is recognized as a powerful tool for assessing cardiovascular health. Although the etiology of OSA remains unclear, saturated fatty acids (SFAs) and cardiovascular health are increasingly regarded as a non-negligible element. This study aims to assess the association between dietary intake of SFAs and the risk of OSA, and the mediating effect of LC9.</p><p><strong>Methods: </strong>Based on the National Health and Nutrition Examination Survey (NHANES), dietary questionnaires of participant were collected, and the average values of 24-h dietary recall data over 2 days were obtained. A continuous cross-sectional analysis with dietary energy adjustment was employed. Weighted multivariable logistic regression models were used to estimate the weighted odds ratios (ORs) and their 95% confidence intervals (CIs) for SFAs and OSA. Evaluate the mediating role of LC9 in the relationship between SFAs and OSA.</p><p><strong>Results: </strong>A total of 13,563 participants aged 20 years and above were included in this study. The intakes of Sfa 4.0 and LC9 among participants with OSA were significantly lower than those in the normal population. After adjusting for confounding factors, total SFAs could increase the risk of OSA [Model 1, Q3, 0.03, 1.49 (1.03, 2.15); Model 2, Q3, 0.04, 1.47 (1.01, 2.13)]. It was emphasized that dietary intake of Sfa 12.0, Sfa 14.0, and Sfa 16.0 were protective factors for OSA, especially among participants aged 45-64 years and white individuals. Moreover, Sfa 12.0 exhibited a better protective effect in female participants [Q3, 0.04, 0.66 (0.45, 0.99)]. In addition, the cardiovascular health score - LC9 had a mediating effect in Sfa4.0 on OSA [Proportion of mediation: -0.035, 95% CI: (-0.058, -0.01); <i>p</i>= 0.002]. There was a nonlinear relationship between dietary intake of Sfa 12.0, Sfa 16.0, and Sfa 18.0 and OSA (<i>P-Nonlinear</i> = 0.013).</p><p><strong>Discussion: </strong>These findings suggest that dietary mixtures of saturated fatty acids increase the risk of OSA. Among them, SFA 4:0 can increase the risk of OSA through the level of cardiovascular health. However, contrary to traditional beliefs, long-chain saturated fatty acids can reduce the risk of OSA.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1503815"},"PeriodicalIF":4.0,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11872719/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Parenteral nutritional support in surgical patients: expert consensus statements regarding intravenous lipid emulsions containing omega-3 fatty acids.
IF 4 2区 农林科学 Q2 NUTRITION & DIETETICS Pub Date : 2025-02-17 eCollection Date: 2025-01-01 DOI: 10.3389/fnut.2025.1546089
Robert G Martindale, David C Evans, Dan Waitzberg, Malissa Warren, Manpreet S Mundi, Stanislaw Klek, Paul E Wischmeyer, Martin D Rosenthal

Objectives: The International Lipids in Parenteral Nutrition (PN) Summit was convened to offer practical guidance and expert consensus opinion regarding the use of intravenous lipid emulsions (ILEs) in various clinical settings. Herein, we briefly review aspects from this summit that are of particular importance for surgical/hospitalized patients.

Methods: Summit participants identified and discussed new evidence, data, and analyses, that potentially influence the benefits and risks of ILEs in PN or their use in clinical practice. The summit meeting consisted of expert presentations that assessed recent clinical data and best practice, followed by periodic panel discussions to formulate consensus statements. Consensus statements were voted on, anonymously, by the meeting attendees.

Results: This review briefly summarizes the rationale for considering ILE choice as a central component of any PN strategy for surgical/hospitalized patients. Thereafter, special patient populations are considered, such as surgery-related intestinal failure, major trauma, and those with chronic critical illnesses. Expert consensus statements are also provided to help bridge the gaps between evidence and clinical practice, hence complementing formal PN societal guideline recommendations.

Conclusion: The choice of ILE in PN, particularly those containing fish oil, can play a vital role in improving outcomes for surgical patients.

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引用次数: 0
The evaluation of food allergy knowledge and attitude in different food sectors and the effectiveness of video-based training.
IF 4 2区 农林科学 Q2 NUTRITION & DIETETICS Pub Date : 2025-02-17 eCollection Date: 2025-01-01 DOI: 10.3389/fnut.2025.1512845
Tugce Aytulu, Beliz Su Gundogdu, Elif Yayci, Isil Ezelsoy, Betul Buyuktiryaki, Mert Veznikli, Sacide Rana Isik, Cansin Sackesen

Objective: Food allergies are common in the food industry. The knowledge and attitude of catering staff are crucial in preventing food allergy (FA)-related reactions. The study aimed to determine the knowledge of FA and evaluate the effectiveness of video-based allergy training for catering personnel in three sectors: restaurants, schools, and hospitals.

Methods: Research has been conducted on workers in three different catering industries: (i) restaurant chains, (ii) school kitchens, and (iii) hospital kitchens. The study involved administering surveys to the staff to measure their demographic data (11 questions), attitude (12 questions), and knowledge level (24 questions) about FA. After taking the pre-test, the participants who watched a 32-min video on FA were asked to fill out post-test questionnaires measuring their knowledge and attitudes.

Results: At the beginning, 619 participants took the pre-test. 45.7 and 40.9% (n = 253) had a previous food Safety Certificate and food allergy training, respectively. Sixty-four percent (n = 397) received our video-based FA training. Among the participants who completed video-based training and the post-test, some knowledge and attitude items improved, but some did not, compared to the pre-test results. Knowledge levels were similar between the previously FA-trained and those untrained individuals.

Conclusion: Our results show that the participants' baseline level of knowledge and attitude for FA needs improvement. After the video training, the level of improvement in some items of knowledge and attitude was significant, but it was lower than expected. It is essential for training to not only provide accurate information but also aim to correct any known misconceptions.

目的:食物过敏在食品行业很常见。餐饮业员工的知识和态度对于预防食物过敏(FA)相关反应至关重要。本研究旨在确定餐饮业、学校和医院这三个行业的餐饮人员对食物过敏的认识,并评估以视频为基础的过敏培训的效果:研究对象为三个不同餐饮行业的员工:(i) 连锁餐厅、(ii) 学校厨房和 (iii) 医院厨房。研究包括对员工进行问卷调查,以了解他们对 FA 的人口统计学数据(11 个问题)、态度(12 个问题)和知识水平(24 个问题)。在进行了前测之后,观看了 32 分钟有关 FA 的视频的参与者被要求填写后测问卷,测量他们的知识和态度:开始时,有 619 人参加了前测。45.7%和40.9%的参与者(n = 253)曾接受过食品安全证书和食物过敏培训。64%的参与者(n = 397)接受了我们的视频FA培训。与测试前的结果相比,在完成视频培训和测试后的参与者中,有些知识和态度项目有所改善,有些则没有。之前接受过 FA 培训的人和未接受过培训的人的知识水平相似:我们的结果表明,参与者对 FA 的基本知识和态度水平有待提高。视频培训后,某些知识和态度项目的改善程度显著,但低于预期。重要的是,培训不仅要提供准确的信息,还要纠正任何已知的错误观念。
{"title":"The evaluation of food allergy knowledge and attitude in different food sectors and the effectiveness of video-based training.","authors":"Tugce Aytulu, Beliz Su Gundogdu, Elif Yayci, Isil Ezelsoy, Betul Buyuktiryaki, Mert Veznikli, Sacide Rana Isik, Cansin Sackesen","doi":"10.3389/fnut.2025.1512845","DOIUrl":"10.3389/fnut.2025.1512845","url":null,"abstract":"<p><strong>Objective: </strong>Food allergies are common in the food industry. The knowledge and attitude of catering staff are crucial in preventing food allergy (FA)-related reactions. The study aimed to determine the knowledge of FA and evaluate the effectiveness of video-based allergy training for catering personnel in three sectors: restaurants, schools, and hospitals.</p><p><strong>Methods: </strong>Research has been conducted on workers in three different catering industries: (i) restaurant chains, (ii) school kitchens, and (iii) hospital kitchens. The study involved administering surveys to the staff to measure their demographic data (11 questions), attitude (12 questions), and knowledge level (24 questions) about FA. After taking the pre-test, the participants who watched a 32-min video on FA were asked to fill out post-test questionnaires measuring their knowledge and attitudes.</p><p><strong>Results: </strong>At the beginning, 619 participants took the pre-test. 45.7 and 40.9% (<i>n</i> = 253) had a previous food Safety Certificate and food allergy training, respectively. Sixty-four percent (<i>n</i> = 397) received our video-based FA training. Among the participants who completed video-based training and the post-test, some knowledge and attitude items improved, but some did not, compared to the pre-test results. Knowledge levels were similar between the previously FA-trained and those untrained individuals.</p><p><strong>Conclusion: </strong>Our results show that the participants' baseline level of knowledge and attitude for FA needs improvement. After the video training, the level of improvement in some items of knowledge and attitude was significant, but it was lower than expected. It is essential for training to not only provide accurate information but also aim to correct any known misconceptions.</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1512845"},"PeriodicalIF":4.0,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11884320/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143572494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrigendum: Various steaming durations alter digestion, absorption, and fermentation by human gut microbiota outcomes of Polygonatum cyrtonema Hua polysaccharides.
IF 4 2区 农林科学 Q2 NUTRITION & DIETETICS Pub Date : 2025-02-17 eCollection Date: 2025-01-01 DOI: 10.3389/fnut.2025.1561857
Weijing Wu, Yanling Wang, Ping Yi, Xufeng Su, Yan Mi, Lanlan Wu, Qianglai Tan

[This corrects the article DOI: 10.3389/fnut.2024.1466781.].

{"title":"Corrigendum: Various steaming durations alter digestion, absorption, and fermentation by human gut microbiota outcomes of <i>Polygonatum cyrtonema</i> Hua polysaccharides.","authors":"Weijing Wu, Yanling Wang, Ping Yi, Xufeng Su, Yan Mi, Lanlan Wu, Qianglai Tan","doi":"10.3389/fnut.2025.1561857","DOIUrl":"https://doi.org/10.3389/fnut.2025.1561857","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/fnut.2024.1466781.].</p>","PeriodicalId":12473,"journal":{"name":"Frontiers in Nutrition","volume":"12 ","pages":"1561857"},"PeriodicalIF":4.0,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11873460/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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Frontiers in Nutrition
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