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Diagnosis of influenza A virus: current molecular tools 甲型流感病毒的诊断：当前的分子工具
IF 3.1 4区 医学 Q3 VIROLOGY
Future Virology
Pub Date : 2023-08-16 DOI: 10.2217/fvl-2023-0091
Sanjit Boora, Anishkumar Khan, S. Kaushik
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引用次数: 0
Evaluation of CLOCK and CSNK1D function in circadian rhythm signaling pathways in HTLV-1 carriers HTLV-1携带者昼夜节律信号通路中CLOCK和CSNK1D功能的评估
IF 3.1 4区 医学 Q3 VIROLOGY
Future Virology
Pub Date : 2023-08-16 DOI: 10.2217/fvl-2023-0050
Mohadeseh Ekhtiari, Fatemeh Bastan, Maryam Rashidian, Mahshid Safavi, Somayeh Yaslianifard, Jafar Ashrafi, F. Kermanian, Sayed-Hamidreza Mozhgani
Aim: Disruption of the internal circadian rhythm pathway could lead to a range of diseases. In this study, we aim to evaluate the circadian rhythm pathway by assessing the interaction between CLOCK and CSNK1D genes in HTLV-1 carriers in comparison with healthy individuals. Materials & methods: CLOCK and CSNK1D gene expression was assessed using the RT-qPCR. Pathogenesis-related signaling networks were designed and analyzed using the obtained results. Results: There was no significant difference in age between the groups. CLOCK and CSNK1D gene expression levels were significantly higher in carriers than in healthy individuals (p = 0.04, p = 0.03, respectively). Conclusion: In addition to introducing potential biological markers, obtained results could be a good idea to further investigate this signaling pathway in the future.
目的：内部昼夜节律途径的破坏可能导致一系列疾病。在这项研究中，我们的目的是通过评估HTLV-1携带者中CLOCK和CSNK1D基因与健康个体之间的相互作用来评估昼夜节律途径。材料与方法：采用RT-qPCR技术检测CLOCK和CSNK1D基因的表达。利用获得的结果设计并分析了与发病机制相关的信号网络。结果：两组患者的年龄差异无统计学意义。携带者的CLOCK和CSNK1D基因表达水平显著高于健康个体（分别为p=0.04和p=0.03）。结论：除了引入潜在的生物标志物外，所获得的结果可能是未来进一步研究该信号通路的好主意。
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引用次数: 0
LMP1 encoded by Epstein–Barr virus may activate AHR through the ERK pathway in nasopharyngeal carcinoma cells EB病毒编码的LMP1可能通过ERK途径激活鼻咽癌细胞的AHR
IF 3.1 4区 医学 Q3 VIROLOGY
Future Virology
Pub Date : 2023-08-08 DOI: 10.2217/fvl-2023-0093
Huifang Jin, Duo Shi, Wen Liu, Yan Zhang, Shuzhen Liu, B. Luo
Aim: To investigate the role of AHR in nasopharyngeal carcinoma (NPC) and explore the relationship between Epstein–Barr virus (EBV) infection and the AHR pathway. Methods: The effect of LMP1 on the expression of AHR was analyzed using real-time PCR and western blot. Proliferation and migration of cells were assessed using CCK8 and Transwell analysis. Results: EBV infection downregulated the expression of AHR in NPC cells, possibly through activation of the ERK pathway by LMP1 thereby accelerating AHR proteasomal degradation following translocation to the nucleus. Cell proliferation, migration and autophagy are promoted by activating the AHR pathway. Conclusion: In NPC cells, LMP1 increases the phosphorylation of ERK, which may activate the AHR pathway.
目的：探讨AHR在鼻咽癌中的作用，探讨EB病毒感染与AHR通路的关系。方法：应用实时聚合酶链反应和蛋白质印迹分析LMP1对AHR表达的影响。使用CCK8和Transwell分析来评估细胞的增殖和迁移。结果：EBV感染下调了NPC细胞中AHR的表达，可能是通过LMP1激活ERK途径，从而加速AHR蛋白酶体移位到细胞核后的降解。细胞增殖、迁移和自噬是通过激活AHR途径来促进的。结论：在NPC细胞中，LMP1增加ERK的磷酸化，可能激活AHR通路。
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引用次数: 0
Screening and identification of dominant B-cell epitopes of human cytomegalovirus UL138 and its clinical applications 人巨细胞病毒UL138显性b细胞表位的筛选鉴定及其临床应用
4区 医学 Q3 VIROLOGY
Future Virology
Pub Date : 2023-08-01 DOI: 10.2217/fvl-2023-0052
Hua Zhu, Xuanlu Xu, Jing Jiang, Xiangyang Xue, Wenmiao Zhang, Ruanmin Zou
Aim: To predict the dominant B-cell epitope of the human cytomegalovirus UL138 gene and to provide a new assay for its latent infection. Methods: Recombinant plasmids were constructed with the predicted dominant epitopes, induced to be expressed and immunized in mice as a way to identify peptide antigenicity, immunogenicity and human serum. Results: Five potentially dominant B-cell epitopes were obtained. The positive rate of detection was found to be significantly higher in neonatal, adult and mouse serum specimens than in human cytomegalovirus (HCMV) (IgG, IgM) and UL138 gene DNA and cDNA assays (p < 0.05). Conclusion: The predicted dominant B-cell epitope is highly sensitive for the detection of human serum HCMV latent infection and can replace the traditional HCMV IgG assay.
目的:预测人巨细胞病毒UL138基因的显性b细胞表位，为其潜伏感染提供新的检测方法。方法:利用预测的优势表位构建重组质粒，诱导其在小鼠体内表达和免疫，鉴定多肽抗原性、免疫原性和人血清。结果:获得5个潜在显性b细胞表位。新生儿、成人和小鼠血清标本的检出率明显高于人巨细胞病毒(HCMV) (IgG、IgM)和UL138基因DNA和cDNA检测(p <0.05)。结论:预测的显性b细胞表位对检测人血清HCMV潜伏感染具有较高的敏感性，可替代传统的HCMV IgG检测方法。
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引用次数: 0
Vertical transmission and maternal passive immunity post-SARS-CoV-2. 严重急性呼吸系统综合征冠状病毒2型后的垂直传播和母体被动免疫。
IF 3.1 4区 医学 Q3 VIROLOGY
Future Virology
Pub Date : 2023-08-01 Epub Date: 2023-10-04 DOI: 10.2217/fvl-2023-0089
Hanie Karimi, Vahid Mansouri, Nima Rezaei

Since 2020, the highly contagious nature and various transmission routes of SARS-CoV-2 have rendered the pandemic interminable. Vertical transmission (VT) through the placenta and breast milk, which is frequent for certain virus types, is thought to exist for SARS-CoV-2 and is hypothesized by many researchers. Conversely, antibodies are produced to counteract the effect of viruses. Since newborns' immunologic system cannot produce proper antibodies, maternal antibodies are usually transferred from mother to infant/fetus to meet the need. This theory leads to the hypothesis of transmission of antibodies through the placenta and breast milk following SARS-CoV-2 infection or vaccination. This paper further discusses these hypotheses, considering consequences of fetus/infant harm versus benefit.

自2020年以来，严重急性呼吸系统综合征冠状病毒2型的高度传染性和各种传播途径使疫情无休止。通过胎盘和母乳的垂直传播（VT）在某些病毒类型中很常见，被认为存在严重急性呼吸系统综合征冠状病毒2型，许多研究人员对此进行了假设。相反，产生抗体是为了抵消病毒的影响。由于新生儿的免疫系统不能产生适当的抗体，母体抗体通常会从母亲转移到婴儿/胎儿身上以满足需求。这一理论导致了严重急性呼吸系统综合征冠状病毒2型感染或接种疫苗后抗体通过胎盘和母乳传播的假设。本文进一步讨论了这些假设，考虑到胎儿/婴儿伤害与利益的后果。
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引用次数: 0
Targeting host calcium channels and viroporins: a promising strategy for SARS-CoV-2 therapy. 靶向宿主钙通道和病毒蛋白:一种有前途的SARS-CoV-2治疗策略
IF 3.1 4区 医学 Q3 VIROLOGY
Future Virology
Pub Date : 2023-08-01 DOI: 10.2217/fvl-2022-0203
Mona Fani, Maryam Moossavi, Hasan Bakhshi, Abozar Nasiri Jahrodi, Mohammad Reza Khazdair, Amir Hossein Zardast, Shokouh Ghafari

Despite passing the pandemic phase of the COVID-19, researchers are still investigating various drugs. Previous evidence suggests that blocking the calcium channels may be a suitable treatment option. Ca2+ is required to enhance the fusion process of Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Also, some important inflammatory factors during SARS-CoV-2 infection are dependent on Ca2+ level. On the other hand, viroporins have emerged as attractive targets for antiviral therapy due to their essential role in viral replication and pathogenesis. By inhibiting the host calcium channels and viroporins, it is possible to limit the spread of infection. Therefore, calcium channel blockers (CCBs) and drugs targeting Viroporins can be considered an effective option in the fight against SARS-CoV-2.

虽然已经度过了大流行阶段，但研究人员仍在研究各种药物。先前的证据表明，阻断钙通道可能是一种合适的治疗选择。Ca2+是增强严重急性呼吸综合征冠状病毒2 (SARS-CoV-2)融合过程所必需的。此外，SARS-CoV-2感染过程中的一些重要炎症因子依赖于Ca2+水平。另一方面，由于病毒孔蛋白在病毒复制和发病机制中的重要作用，它们已成为抗病毒治疗的有吸引力的靶点。通过抑制宿主钙通道和病毒孔蛋白，可以限制感染的传播。因此，钙通道阻滞剂(CCBs)和靶向病毒蛋白的药物可以被认为是对抗SARS-CoV-2的有效选择。
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引用次数: 0
A single antiviral for a triple epidemic: is it possible? 一种抗病毒药物对付三种流行病:可能吗?
IF 3.1 4区 医学 Q3 VIROLOGY
Future Virology
Pub Date : 2023-07-29 DOI: 10.2217/fvl-2023-0048
N. Sultanoglu, E. Erdag, Cenk Serhan Ozverel
Aim: A triple epidemic of respiratory syncytial virus (RSV), SARS-CoV-2 and influenza variants is on the rise worldwide. It is crucial to identify antiviral agents that can be used against all three viruses associatd with this triple epidemic. Materials & methods: A total of ten antiviral agents were investigated in this study. Using molecular docking and the molecular mechanics/position-Boltzmann surface area technique, an examination of the binding affinity and protein–ligand interactions was conducted. Results: Out of the ten ligands that were compared, three showed the highest affinity for the docking site related to three the viral infections in descending order: AVG-388, remdesivir and nirmatrelvir. Conclusion: In conclusion, AVG-388, remdesivir and nirmatrelvir could be recommended as effective antiviral agents during the triple epidemic.
目的:呼吸道合胞病毒(RSV)、SARS-CoV-2和流感变体在全球范围内呈上升趋势。至关重要的是确定可用于对抗与这三重流行病相关的所有三种病毒的抗病毒药物。材料与方法:对10种抗病毒药物进行了研究。利用分子对接和分子力学/位置-玻尔兹曼表面积技术，研究了蛋白质与配体的结合亲和力和相互作用。结果:在10个配体中，AVG-388、remdesivir和nirmatrelvir对与3种病毒感染相关的对接位点的亲和力由高到低依次为3个配体。结论:AVG-388、remdesivir和nirmatrelvir在三联流行时可推荐作为有效的抗病毒药物。
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引用次数: 0
Plasma IL-10, IL-19 and IL-32 are potential biomarkers for adenovirus-induced severe pneumonia in pediatric patients 血浆IL-10、IL-19和IL-32是腺病毒诱导的小儿重症肺炎的潜在生物标志物
IF 3.1 4区 医学 Q3 VIROLOGY
Future Virology
Pub Date : 2023-07-29 DOI: 10.2217/fvl-2023-0080
Jing Chen, Guoyun Su, Ruimu Zhang, Jikui Deng, Lifeng Qi
Aim: This study aimed to identify potential plasma biomarkers for severe pediatric adenovirus (AdV) infection. Methods: Thirty-seven inflammatory proteins were measured in the plasma of AdV-infected, influenza H3N2-infected or healthy pediatric participants and the prediction values of selected inflammatory proteins for AdV and severe AdV were assessed. Results: The expression profiles of AdV- and H3N2-infected patients were largely similar, with only IL-2, IL-10, IL-19 and IL-32 showing pathogen-dependent expression. IL-10, IL-19 and IL-32, both individually and in combination, could predict AdV and severe AdV infection. Conclusion: Plasma IL-10, IL-19 and IL-32 are potential biomarkers for AdV, especially severe AdV in pediatric patients.
目的：本研究旨在确定严重儿童腺病毒（AdV）感染的潜在血浆生物标志物。方法：测量AdV感染者、H3N2流感感染者或健康儿童参与者血浆中的37种炎症蛋白，并评估所选炎症蛋白对AdV和严重AdV的预测值。结果：AdV-和H3N2感染患者的表达谱基本相似，只有IL-2、IL-10、IL-19和IL-32表现出病原体依赖性表达。IL-10、IL-19和IL-32，无论是单独还是联合使用，都可以预测AdV和严重的AdV感染。结论：血浆IL-10、IL-19和IL-32是儿童AdV，尤其是严重AdV的潜在生物标志物。
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引用次数: 0
Respiratory syncytial virus: an overview 呼吸道合胞病毒：综述
IF 3.1 4区 医学 Q3 VIROLOGY
Future Virology
Pub Date : 2023-07-29 DOI: 10.2217/fvl-2023-0037
A. Aljabali, Mohammad A. Obeid, Mohamed El-Tanani, M. Tambuwala
Respiratory syncytial virus (RSV) is a leading cause of respiratory illnesses that primarily affects children, particularly those under 2 years old, and adults. RSV infections can lead to hospitalization and even mortality. The virus is transmitted through respiratory droplets spread by coughing or sneezing. We conducted an extensive literature search focused on RSV, pathogenicity and relevant keywords like ‘RSV treatment,’ ‘RSV vaccine,‘ and ‘RSV diagnosis’ to explore effective treatment strategies, advances in potential RSV vaccines and ongoing clinical trials, and progress in diagnostic techniques for accurate and timely detection of RSV infections. These findings are crucial for developing appropriate management and control measures.
呼吸道合胞病毒（RSV）是呼吸道疾病的主要原因，主要影响儿童，尤其是2岁以下的儿童和成年人。呼吸道合胞病毒感染可导致住院甚至死亡。病毒通过咳嗽或打喷嚏传播的呼吸道飞沫传播。我们进行了广泛的文献检索，重点关注呼吸道合胞病毒、致病性和相关关键词，如“RSV治疗”、“RSV疫苗”和“RSV诊断”，以探索有效的治疗策略、潜在RSV疫苗和正在进行的临床试验的进展，以及准确及时检测RSV感染的诊断技术的进展。这些发现对于制定适当的管理和控制措施至关重要。
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引用次数: 0
Ebola virus is nature's wake-up call 埃博拉病毒是大自然的警钟
IF 3.1 4区 医学 Q3 VIROLOGY
Future Virology
Pub Date : 2023-07-29 DOI: 10.2217/fvl-2023-0118
S. Kaushik, Ramesh Kumar, S. Kaushik
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引用次数: 0
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