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Microleakage Evaluation of Two Methacrylate-Based Composites (GC Kalore and Luna SDI) in Class II Restorations: A Laboratory Study. 两种甲基丙烯酸酯基复合材料(GC Kalore和Luna SDI)在II类修复体中的微泄漏评价:实验室研究。
IF 3.1 Q3 MATERIALS SCIENCE, BIOMATERIALS Pub Date : 2022-01-01 DOI: 10.1155/2022/3835694
Kooshan Moradi, Sadaf Sadat Mahmoudinezhad, Mehran Mapar

Objective: In recent years, dental composite resins such as tooth-colored restoration are frequently used to restore dental cavities, coronal fractures, and congenital defects. This study aimed to evaluate the microleakage of two methacrylate-based composites (GC Kalore and Luna SDI) in class II restorations.

Materials and methods: In this experimental study, a total of 18 intact human premolars previously extracted for periodontal and orthodontic reasons were randomly divided into two groups. Similar class II cavities (box only) were prepared on all teeth and restored with two different composites. In group 1, a bonding agent (Single Bond 2-SB2; 3M ESPE) and Luna SDI composite in mesial cavities and GC Kalore composite in distal cavities were used. In group 2, Single Bond 2 and GC Kalore composite in mesial cavities and Luna SDI composite in distal cavities were applied. They were then subjected to 2000 thermal cycles in a water bath between 5-55°C (dwell time: 30 seconds in every bath and transfer time: 10 seconds). Then, they were immersed in a 2% basic fuchsin dye solution for 24 hours. After rinsing with water, they were sectioned mesiodistally and evaluated for microleakage using a stereomicroscope.

Results: Independent t-test (Mann-Whitney test) showed no statistically significant difference for microleakage in mesial and distal class II restorations between GC Kalore composite and Luna SDI composite (p = 1.000) (p= 0.852). A total of 83.4% of the Luna SDI composite samples and 66.6% of the GC Kalore composite had a microleakage score of ≤3 in class II cavities.

Conclusion: In the present study, marginal microleakage was found mainly at the gingival floor extending to 1/3 of the axial wall for the Luna SDI composite and GC Kalore composite. Furthermore, no statistically significant difference was found between the microleakage of the Class II cavities restored with Luna SDI composite and GC Kalore composite.

目的:近年来,牙色修复等牙科复合树脂被广泛应用于口腔、冠状面骨折和先天性缺损的修复。本研究旨在评价两种甲基丙烯酸酯基复合材料(GC Kalore和Luna SDI)在II类修复体中的微渗漏。材料和方法:本实验选取18颗因牙周和正畸原因拔出的完整人前磨牙,随机分为两组。在所有牙齿上制备类似的II类空腔(仅盒子),并使用两种不同的复合材料修复。第1组为键合剂(单键2-SB2;中腔采用3M ESPE和Luna SDI复合材料,远腔采用GC Kalore复合材料。第2组中腔采用Single Bond 2和GC Kalore复合材料,远腔采用Luna SDI复合材料。然后在5-55°C的水浴中进行2000次热循环(每次水浴停留时间:30秒,转移时间:10秒)。然后,将它们浸泡在2%的碱性品红染料溶液中24小时。用水冲洗后,对其进行中间距切片,并用立体显微镜评估微渗漏情况。结果:独立t检验(Mann-Whitney检验)显示GC Kalore复合材料与Luna SDI复合材料中、远端II类修复体的微渗漏差异无统计学意义(p= 1.000) (p= 0.852)。Luna SDI复合材料中83.4%的样品和GC Kalore复合材料中66.6%的样品在II类空腔中微泄漏评分≤3。结论:在本研究中,Luna SDI复合材料和GC Kalore复合材料的边缘微漏主要发生在牙龈底,延伸至轴壁的1/3处。Luna SDI复合材料与GC Kalore复合材料修复的II类空腔微渗漏无统计学差异。
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引用次数: 0
Comparative Analysis of the Efficiency of Medicinal Plants for the Treatment and Prevention of COVID-19. 几种药用植物治疗和预防新型冠状病毒病疗效的比较分析。
IF 3.1 Q3 MATERIALS SCIENCE, BIOMATERIALS Pub Date : 2022-01-01 DOI: 10.1155/2022/5943649
Viktor Kamkin, Aidana Kamarova, Baurzhan Shalabayev, Assyltas Kussainov, Marat Anuarbekov, Serik Abeuov

The COVID-19 pandemic has once again prompted people to resort to the remedies of folk and alternative medicine. Medicinal plants, because of their chemical composition, pharmacological properties, and the action of biologically active substances, can stop and relieve the symptoms of the disease. The purpose of the work is a comparative flora analysis of medicinal plants to identify the most prospective plant and further production of a remedy for the avoidance, treatment, and rehabilitation of COVID-19. The search for prospective medicinal plants was performed by analyzing the literature in online databases: Web of Science, Scopus, Google Scholar, and PubMed, including official WHO media sites. According to recent studies related to COVID-19, a significant number of medicinal plants with anti-inflammatory, antiviral, and immunostimulatory effects have been identified. A comparative study of nine medicinal plants was conducted to determine the most suitable medicinal plant to treat coronavirus infection. According to the results of the comparative analysis, Chamaenerion angustifolium Seg. showed itself as the most prospective medicinal plant with the greatest pharmacological effect compared with other types of medicinal plants. Its therapeutic properties allow physiological relief of 18 symptoms of coronavirus infection. It is advisable to conduct further clinical trials for the treatment and rehabilitation of COVID-19 using preparations from this plant.

新冠肺炎疫情再次促使人们求助于民间疗法和替代医学。药用植物由于其化学成分、药理特性和生物活性物质的作用,可以阻止和缓解疾病的症状。这项工作的目的是对药用植物进行比较菌群分析,以确定最有前景的植物和进一步生产用于预防、治疗和康复COVID-19的药物。通过分析在线数据库(Web of Science、Scopus、Google Scholar和PubMed)中的文献,包括世卫组织官方媒体网站,进行了潜在药用植物的搜索。根据最近与COVID-19相关的研究,已经发现了大量具有抗炎、抗病毒和免疫刺激作用的药用植物。通过对9种药用植物的比较研究,确定了最适合治疗冠状病毒感染的药用植物。根据比较分析的结果,长沙锦绣菇属植物。与其他类型的药用植物相比,其药理作用最大,是最有发展前景的药用植物。它的治疗特性可以从生理上缓解冠状病毒感染的18种症状。建议进一步开展利用该植物制剂治疗和康复COVID-19的临床试验。
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引用次数: 1
The Optimal Timing of Platelet-Rich Plasma (PRP) Injection for Nerve Lesion Recovery: A Preliminary Study. 富血小板血浆(PRP)注射用于神经损伤恢复的最佳时机:初步研究。
IF 3.1 Q3 MATERIALS SCIENCE, BIOMATERIALS Pub Date : 2022-01-01 DOI: 10.1155/2022/9601547
Muhammad Pandunugrahadi, Komang Agung Irianto, Oen Sindrawati

Introduction: Without appropriate treatment, nerve injuries may result in permanent loss of function. Platelet-rich plasma (PRP) injection is found to help in nerve regeneration. PRP is a concentrated platelet derived from autologous blood with the potential to release various growth factors (GF) to promote nerve regeneration. This study aims to know the best time for PRP injection to promote nerve regeneration.

Methods: This is an experimental in vivo research using male New Zealand white rabbits in the randomized control group posttest only design. Samples were divided into 5 groups (1 control group and 4 treatment groups). The control group without PRP injection and treated groups injected immediately after nerve injury, 3 days, 7 days, and 14 days afterward. Nerve regeneration was evaluated by the histology specimen sacrificed on day 21. Inflammation cells and endoneurium vacuoles were counted as mean percentage of five nerve fragments in each injured nerve sample specimen.

Result: Inflammation cells and vacuole cells increased significantly when PRP was administered 3 days after injury (group 2) (respectively, 14 ± 6.7 and 56.6 ± 11.6) compared to all treatment groups (p < 0.005) (control group, respectively, 6 ± 2.6 and 15.7 ± 9.5). On the other hand, significantly lower endoneurium vacuoles and inflammation cells were found on "the day 14" sample group (respectively, 5 ± 1.3 and 5.2 ± 1.6) compared to all other groups (p < 0.005).

Conclusion: This study found that the best time for injecting PRP for nerve regeneration is 14 days after injury.

如果不进行适当的治疗,神经损伤可能导致永久性的功能丧失。富血小板血浆(PRP)注射被发现有助于神经再生。PRP是来源于自体血液的浓缩血小板,具有释放各种生长因子(GF)促进神经再生的潜力。本研究旨在了解PRP注射促进神经再生的最佳时机。方法:本实验采用体内实验研究,以雄性新西兰大白兔为随机对照组,后验单设计。将样品分为5组(1个对照组和4个治疗组)。对照组不注射PRP,治疗组在神经损伤后立即、3 d、7 d、14 d注射PRP。第21天处死组织学标本评价神经再生情况。炎症细胞和神经内膜空泡计数为每个损伤神经样本标本中5个神经碎片的平均百分比。结果:损伤后3 d给予PRP组(2组)炎症细胞和液泡细胞(分别为14±6.7和56.6±11.6)明显高于各治疗组(对照组,分别为6±2.6和15.7±9.5)(p < 0.005)。另一方面,“第14天”样品组的神经内膜液泡和炎症细胞数量分别为5±1.3个和5.2±1.6个,显著低于其他各组(p < 0.005)。结论:本研究发现在损伤后14天注射PRP进行神经再生的最佳时间。
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引用次数: 0
Influence of Breast Implant Surface Finishing on Physicochemical and Mechanical Properties before and after Extreme Degradation Studies. 极端降解研究前后乳房植入物表面处理对物理化学和机械性能的影响
IF 3 Q3 MATERIALS SCIENCE, BIOMATERIALS Pub Date : 2021-06-29 eCollection Date: 2021-01-01 DOI: 10.1155/2021/8850577
Izabelle de Mello Gindri, Lucas Kuth de Azambuja, Michele da Silva Barreto, Dionatha José do Prado, Gean Vitor Salmoria, Carlos Rodrigo de Mello Roesler

The influence of the surface finishing of breast implants on physicochemical and mechanical properties, before and after extreme degradation experiments, was investigated in this study. Removal of superficial layers after degradation was verified for both smooth and rough membranes, in which local erosion was verified. FTIR results demonstrated the generation of low-molecular-weight structures in all samples due to exposure to acidic and basic environments. Furthermore, smooth samples presented higher degrees of crosslinking than rough samples. Considering the mechanical properties, no difference was verified between smooth and rough samples as received and after degradation studies. However, the pH of the degradation solution had an influence on mechanical properties of the material and a basic environment caused greater deterioration of the mechanical properties compared to acidic conditions.

本研究调查了乳房植入物在极端降解实验前后的表面处理对物理化学和机械性能的影响。光滑膜和粗糙膜在降解后的表层脱落都得到了验证,其中局部侵蚀也得到了验证。傅立叶变换红外光谱(FTIR)结果表明,由于暴露在酸性和碱性环境中,所有样品都产生了低分子量结构。此外,光滑样品的交联度高于粗糙样品。在机械性能方面,光滑样品和粗糙样品在收到时和降解研究后没有差异。不过,降解溶液的 pH 值对材料的机械性能有影响,与酸性环境相比,碱性环境导致的机械性能恶化程度更大。
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引用次数: 0
Characterization and Inhibitory Effects of Magnetic Iron Oxide Nanoparticles Synthesized from Plant Extracts on HeLa Cells. 植物提取物制备的磁性氧化铁纳米颗粒的表征及对HeLa细胞的抑制作用
IF 3.1 Q3 MATERIALS SCIENCE, BIOMATERIALS Pub Date : 2020-12-10 eCollection Date: 2020-01-01 DOI: 10.1155/2020/2630735
Bernard Owusu Asimeng, Emmanuel Nyankson, Johnson Kwame Efavi, Amartey Nii Amarkai, Gloria Pokuaa Manu, Elvis Tiburu

Magnetic Fe3O4 nanoparticles were synthesized from maize leaves and plantain peels extract mediators. Particles were characterized, and the inhibitory effects were studied on HeLa cells in vitro using cyclic voltammetry (CV). Voltammograms from the CV show that Fe3O4 NPs interaction with HeLa cells affected their electrochemical behavior. The nanoparticles formed with higher Fe3+/Fe2+ molar ratio (2.8 : 1) resulted in smaller crystallite sizes compared to those formed with lower Fe3+/Fe2+ molar ratio (1.4 : 1). The particles with the smallest crystallite size showed higher anodic peak currents, whereas the larger crystallite sizes resulted in lower anodic peak currents. The peak currents relate to cell inhibition and are confirmed by the half-maximum inhibitory concentration (IC50). The findings show that the particles have a different inhibitory mechanism on HeLa cells ion transfer and are promising to be further exploited for cancer treatment.

以玉米叶和车前草皮提取物为介质合成了磁性纳米Fe3O4。采用循环伏安法(CV)对颗粒进行了表征,并研究了其对体外HeLa细胞的抑制作用。伏安图显示Fe3O4 NPs与HeLa细胞的相互作用影响了它们的电化学行为。高Fe3+/Fe2+摩尔比(2.8:1)形成的纳米颗粒晶粒尺寸小于低Fe3+/Fe2+摩尔比(1.4:1)形成的纳米颗粒。晶粒尺寸越小,阳极峰值电流越高,晶粒尺寸越大,阳极峰值电流越低。峰值电流与细胞抑制有关,并由半最大抑制浓度(IC50)证实。研究结果表明,该颗粒对HeLa细胞离子转移具有不同的抑制机制,有望进一步开发用于癌症治疗。
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引用次数: 4
Green Synthesis and Antibacterial Activity of HAp@Ag Nanocomposite Using Centella asiatica (L.) Urban Extract and Eggshell. 利用积雪草(L.)城市提取物和蛋壳绿色合成 HAp@Ag 纳米复合材料并提高其抗菌活性
IF 3.1 Q3 MATERIALS SCIENCE, BIOMATERIALS Pub Date : 2020-10-01 eCollection Date: 2020-01-01 DOI: 10.1155/2020/8841221
Xuan Nui Pham, Hoa Thi Nguyen, Ngan Thi Pham

In recent years, the green synthesis of nanoparticles via biological processes has attracted considerable attention. Herein, we introduce a facile and green approach for the synthesis of poriferous silver nanoparticles (Ag-NPs) decorated hydroxylapatite (HAp@Ag) nanoparticles with excellent antibacterial properties. All the nanocomposites were fully characterized in the solid state via various techniques such as X-ray powder diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), and energy-dispersive X-ray spectrometer (EDX), in which the synthesized Ag-NPs (24 nm in diameter) and their homogeneous incorporation on HAp have been studied by ultraviolet-visible (UV-vis) technique, transmission electron microscopy (TEM), and dynamic light scattering (DLS) analysis. The obtained results indicate that the structure and morphology of HAp have no significant changes after the incorporation of Ag-NPs on its surface. Moreover, an impressive antibacterial activity of HAp@Ag nanocomposite against Gram-positive bacterium Staphylococcus aureus and Gram-negative bacteria Escherichia coli and Pseudomonas aeruginosa has been recorded by using the agar well diffusion method. As a result, the HAp@Ag nanocomposite promises to be a great biomedical material with high antibacterial properties.

近年来,通过生物过程绿色合成纳米粒子引起了广泛关注。在此,我们介绍了一种简便、绿色的方法,用于合成具有优异抗菌性能的多孔银纳米颗粒(Ag-NPs)装饰羟基磷灰石(HAp@Ag)纳米颗粒。通过 X 射线粉末衍射(XRD)、傅立叶变换红外光谱(FT-IR)、扫描电子显微镜(SEM)和能量色散 X 射线光谱仪(EDX)等多种技术,对所有纳米复合材料的固态特性进行了充分表征、其中,紫外可见光(UV-vis)技术、透射电子显微镜(TEM)和动态光散射(DLS)分析研究了合成的 Ag-NPs(直径 24 nm)及其在 HAp 上的均匀结合。结果表明,在 HAp 表面掺入 Ag-NPs 后,其结构和形态没有发生显著变化。此外,利用琼脂井扩散法记录了 HAp@Ag 纳米复合材料对革兰氏阳性菌金黄色葡萄球菌、革兰氏阴性菌大肠杆菌和绿脓杆菌的抗菌活性。因此,HAp@Ag 纳米复合材料有望成为一种具有高度抗菌性能的生物医学材料。
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引用次数: 0
Response to: Comment on "The Use of Pulsed Electromagnetic Fields to Promote Bone Responses to Biomaterials In Vitro and In Vivo". 回复:对“利用脉冲电磁场促进骨对体外和体内生物材料的反应”的评论。
IF 3.1 Q3 MATERIALS SCIENCE, BIOMATERIALS Pub Date : 2020-09-29 eCollection Date: 2020-01-01 DOI: 10.1155/2020/9801420
G Pedrazzi, C Galli, M Mattioli-Belmonte, S Guizzardi

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引用次数: 1
Functionalized Glutathione on Chitosan-Genipin Cross-Linked Beads Used for the Removal of Trace Metals from Water. 壳聚糖-吉尼平交联珠上的功能化谷胱甘肽用于去除水中的微量金属。
IF 3.1 Q3 MATERIALS SCIENCE, BIOMATERIALS Pub Date : 2020-09-14 eCollection Date: 2020-01-01 DOI: 10.1155/2020/4158086
Samira R Akaji, David Dewez

Functionalized glutathione on chitosan-genipin cross-linked beads (CS-GG) was synthesized and tested as an adsorbent for the removal of Fe(II) and Cu(II) from aqueous solution. The beads were characterized by several techniques, including Fourier-transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), CNS elementary analysis, scanning electron microscopy (SEM), and atomic force microscopy (AFM). The effect of several parameters such as the pH, the temperature, and the contact time was tested to optimize the condition for the adsorption reaction. The beads were incubated in aqueous solutions contaminated with different concentrations of Fe(II) and Cu(II) (under the range concentration from 10 to 400 mg·L-1), and the adsorption capacity was evaluated by inductively coupled plasma optical emission spectrometry (ICP-OES). The adsorption equilibrium was reached after 120 min of incubation under optimal pH 5 for Fe(II) and after 180 min under optimal pH 6 for Cu(II). According to the Langmuir isotherm, the maximum adsorption capacities (q max) for Fe(II) and Cu(II) were 208 mg·g-1 and 217 mg·g-1, respectively. Our results showed that the adsorption efficiency of both metals on CS-GG beads was correlated with the degree of temperature. In addition, the adsorption reaction was spontaneous and endothermic, indicated by the positive values of ΔG 0 and ΔH 0. Therefore, the present study demonstrated that the new synthesized CS-GG beads had a strong adsorption capacity for Fe(II) and Cu(II) and were efficient to remove these trace metals from aqueous solution.

合成了壳聚糖-基因蛋白交联珠(CS-GG)上的功能化谷胱甘肽,并将其作为一种吸附剂用于去除水溶液中的铁(II)和铜(II)。研究采用了多种技术对珠子进行了表征,包括傅立叶变换红外光谱(FTIR)、热重分析(TGA)、CNS 基本分析、扫描电子显微镜(SEM)和原子力显微镜(AFM)。测试了 pH 值、温度和接触时间等几个参数的影响,以优化吸附反应的条件。在不同浓度的铁(II)和铜(II)(浓度范围为 10 至 400 mg-L-1)污染的水溶液中培养珠子,并用电感耦合等离子体光发射光谱法(ICP-OES)评估其吸附能力。在最佳 pH 值为 5 的条件下,铁(II)在培养 120 分钟后达到吸附平衡;在最佳 pH 值为 6 的条件下,铜(II)在培养 180 分钟后达到吸附平衡。根据 Langmuir 等温线,Fe(II) 和 Cu(II) 的最大吸附容量(q max)分别为 208 mg-g-1 和 217 mg-g-1。结果表明,两种金属在 CS-GG 微珠上的吸附效率与温度的高低有关。因此,本研究表明新合成的 CS-GG 珠子对铁(II)和铜(II)具有很强的吸附能力,能有效地去除水溶液中的这些痕量金属。
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引用次数: 0
Extraction and Characterization of Novel Natural Hydroxyapatite Bioceramic by Thermal Decomposition of Waste Ostrich Bone. 废鸵鸟骨热分解提取新型天然羟基磷灰石生物陶瓷及其表征。
IF 3.1 Q3 MATERIALS SCIENCE, BIOMATERIALS Pub Date : 2020-08-28 eCollection Date: 2020-01-01 DOI: 10.1155/2020/1690178
Komal Prasad Malla, Sagar Regmi, Achyut Nepal, Sitaram Bhattarai, Ram Jeewan Yadav, Shinichi Sakurai, Rameshwar Adhikari

A novel natural hydroxyapatite (HAp) bioceramic was extracted from the ostrich cortical bone by the thermal decomposition method. HAp was characterized by different analytical tools such as thermogravimetric analysis (TGA), Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) analysis, and scanning electron microscopy (SEM). Removal of organic impurities from the bone powder was confirmed by TGA analysis. FTIR spectra of HAp confirmed the presence of the major functional groups such as phosphate (PO4 3-), hydroxyl (OH-), and carbonate (CO3 2-) in the bioceramic. The XRD data revealed that the HAp was the crystalline phase obtained by calcination of the bone powder at 950°C, and the SEM analyses confirmed the typical plate-like texture of the nanosized HAp crystals.

采用热分解法从鸵鸟皮质骨中提取一种新型天然羟基磷灰石(HAp)生物陶瓷。利用热重分析(TGA)、傅里叶变换红外光谱(FTIR)、x射线衍射(XRD)和扫描电镜(SEM)等分析工具对HAp进行了表征。通过热重分析证实了骨粉中有机杂质的去除。羟基磷灰石的FTIR光谱证实了生物陶瓷中主要官能团如磷酸(po43 -)、羟基(OH-)和碳酸盐(co32 -)的存在。XRD分析表明HAp为骨粉950℃煅烧后的结晶相,SEM分析证实HAp具有典型的片状结构。
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引用次数: 29
Nonirritant and Cytocompatible Tinospora cordifolia Nanoparticles for Topical Antioxidant Treatments. 用于局部抗氧化治疗的无刺激性和细胞相容性堇叶Tinospora cordifolia纳米颗粒。
IF 3 Q3 MATERIALS SCIENCE, BIOMATERIALS Pub Date : 2020-08-21 eCollection Date: 2020-01-01 DOI: 10.1155/2020/3637098
Jeimmy González-Masís, Jorge M Cubero-Sesin, Yendry Regina Corrales-Ureña, Sara González-Camacho, Nohelia Mora-Ugalde, José Roberto Vega-Baudrit, Klaus Rischka, Virendra Verma, Rodolfo J Gonzalez-Paz

Tinospora cordifolia extract contains antioxidants such as polyphenols, and thus, it has been used as a natural phytochemical antioxidant therapeutic agent. Many of these compounds are insoluble or only partially soluble in water. In this study, we produced a novel aqueous nanoparticle formulation, with an average particle size of 182.9 ± 3.8 nm, to improve the dispersion of the bioactive compounds in water and to increment its bioavailability. The nanoparticles are composed of polyphenols, alkaloids, and glycosides. We studied the effect of this nanoparticle formulation on mouse 3T3 fibroblast cell viability and New Zealand rabbit dermal irritability tests. Concentrations of 2.5, 25, and 250 µg/mL resulted in similar cell viability to cells in culture media. An intermediate concentration of 12.45 mg/ml was used for the acute dermal irritability test. There were no severe alterations that compromised animal health. These results represent a precedent for application of such nanoparticles derived from plant stems, such as Tinospora cordifolia, in biomedicine and in antiaging cosmetic treatments.

堇青花提取物中含有多酚类抗氧化剂,是一种天然的植物化学抗氧化治疗剂。这些化合物中有许多不溶于水或仅部分溶于水。在本研究中,我们制备了一种平均粒径为182.9±3.8 nm的新型水相纳米颗粒配方,以改善生物活性化合物在水中的分散,提高其生物利用度。纳米颗粒由多酚、生物碱和糖苷组成。我们研究了该纳米颗粒制剂对小鼠3T3成纤维细胞活力和新西兰兔皮肤过敏性试验的影响。2.5、25和250µg/mL浓度的细胞活力与培养基中的细胞相似。急性皮肤刺激试验采用中间浓度12.45 mg/ml。没有严重影响动物健康的变化。这些结果为从植物茎中提取的纳米颗粒(如Tinospora cordifolia)应用于生物医学和抗衰老美容治疗提供了先例。
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引用次数: 0
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International Journal of Biomaterials
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