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Preparation and In Vitro Evaluation of Alginate Microparticles Containing Amphotericin B for the Treatment of Candida Infections. 含两性霉素B藻酸盐微粒治疗念珠菌感染的制备及体外评价。
IF 3.1 Q3 MATERIALS SCIENCE, BIOMATERIALS Pub Date : 2020-08-01 eCollection Date: 2020-01-01 DOI: 10.1155/2020/2514387
Merlis P Alvarez-Berrios, Lisa M Aponte-Reyes, Lourdes Diaz-Figueroa, Juan Vivero-Escoto, Alexis Johnston, David Sanchez-Rodriguez

Invasive candidiasis (IC) remains as a major cause of morbidity and mortality in critically ill patients. Amphotericin B (AmB) is one of the most effective antifungal agents commonly used to treat this infection. However, it induces severe side effects such as nephrotoxicity, cardiac alterations, nausea, fever, and liver damage. The utilization of drug delivery systems has been explored to overcome these limitations. Several AmB lipid formulations have been developed and are currently available in the market. Although they have the ability to reduce the main side effects of free AmB, their high cost, necessity of repeated intravenous injections for successful treatment, and incidence of pulmonary toxicity have limited their use. In the last decades, alginate has gained significant interest in drug delivery applications as a cost-effective strategy to improve the safety and therapeutic effect of toxic drugs. In this work, the clinically relevant drug AmB was encapsulated into alginate microparticles using the emulsification/external gelation method. We hypothesize that this synthesis strategy may positively impact the antifungal efficacy of AmB-loaded MCPs toward Candida albicans cells while reducing the toxicity in human lung cells. To prove this hypothesis, the ability of the microplatform to disrupt the cellular membrane potential was tested and its antifungal effectiveness toward Candida albicans cells was evaluated using the cell counting and plate count methods. Moreover, the toxicity of the microplatform in human lung cells was evaluated using CellTiter 96® AQueous cell viability assay and qualitative diffusion analysis of acridine orange. Our results demonstrated that the platform developed in this work was able to induce antifungal toxicity against Candida albicans yeast cells at the same level of free AmB with minimal toxicity to lung cells, which is one of the main side effects induced by commercial drug delivery systems containing AmB. Overall, our data provides convincing evidence about the effectiveness of the alginate-based microplatform toward Candida albicans cells. In addition, this vehicle may not require several infusions for a successful treatment while reducing the pulmonary toxic effect induced by commercial lipid formulations.

侵袭性念珠菌病(IC)仍然是危重病人发病和死亡的主要原因。两性霉素B (AmB)是最有效的抗真菌药物之一,通常用于治疗这种感染。然而,它会引起严重的副作用,如肾毒性、心脏改变、恶心、发烧和肝损伤。利用药物输送系统已经被探索以克服这些限制。已经开发了几种AmB脂质配方,目前在市场上可用。虽然它们有能力减少游离AmB的主要副作用,但它们的高成本、成功治疗需要反复静脉注射以及肺毒性的发生率限制了它们的使用。在过去的几十年里,海藻酸盐作为一种提高毒性药物安全性和治疗效果的成本效益策略,在药物递送应用中获得了极大的兴趣。本研究采用乳化/外凝胶法将临床相关药物AmB包封在海藻酸盐微颗粒中。我们假设这种合成策略可能会积极影响amb负载的MCPs对白色念珠菌细胞的抗真菌功效,同时降低对人肺细胞的毒性。为了证明这一假设,我们测试了微平台破坏细胞膜电位的能力,并利用细胞计数和平板计数方法评估了微平台对白色念珠菌细胞的抗真菌效果。此外,采用CellTiter 96®水细胞活力测定和吖啶橙定性扩散分析评估微平台对人肺细胞的毒性。我们的研究结果表明,本研究开发的平台能够在相同水平的游离AmB下诱导对白色念珠菌酵母细胞的抗真菌毒性,同时对肺细胞的毒性最小,这是含有AmB的商业药物递送系统诱导的主要副作用之一。总的来说,我们的数据为基于海藻酸盐的微平台对白色念珠菌细胞的有效性提供了令人信服的证据。此外,这种载体可能不需要多次输注即可成功治疗,同时减少由商业脂质制剂引起的肺毒性作用。
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引用次数: 4
Influence of Titanium Alloy Scaffolds on Enzymatic Defense against Oxidative Stress and Bone Marrow Cell Differentiation. 钛合金支架对氧化应激酶防御及骨髓细胞分化的影响。
IF 3.1 Q3 MATERIALS SCIENCE, BIOMATERIALS Pub Date : 2020-07-29 eCollection Date: 2020-01-01 DOI: 10.1155/2020/1708214
Lais Morandini Rodrigues, Elis Andrade Lima Zutin, Elisa Mattias Sartori, Daniela Baccelli Silveira Mendonça, Gustavo Mendonça, Yasmin Rodarte Carvalho, Luana Marotta Reis de Vasconcellos

Studies have been directed towards the production of new titanium alloys, aiming for the replacement of Ti-6 Aluminium-4 Vanadium (TiAlV) alloy in the future. Many mechanisms related to biocompatibility and chemical characteristics have been studied in the field of implantology, but enzymatic defenses against oxidative stress remain underexplored. Bone marrow stromal cells have been explored as source of cells, which have the potential to differentiate into osteoblasts and therefore could be used as cells-based therapy. The objective of this study was to evaluate the activity of the antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT) in porous scaffolds of Ti-6 Aluminium-4 Vanadium (TiAlV), Ti-35 Niobium (TiNb), and Ti-35 Niobium-7 Zirconium-5 Tantalum (TiNbZrTa) on mouse bone marrow stromal cells. Porous titanium alloy scaffolds were prepared by powder metallurgy. After 24 hours, cells plated on the scaffolds were analyzed by scanning electron microscopy (SEM). The antioxidant enzyme activity was measured 72 hours after cell plating. Quantitative real time PCR (qRT-PCR) was performed after 3, 7, and 14 days, and Runx2 (Runt-related transcription factor2) expression was evaluated. The SEM images showed the presence of interconnected pores and growth, adhesion, and cell spreading in the 3 scaffolds. Although differences were noted for SOD and CAT activity for all scaffolds analyzed, no statistical differences were observed (p > 0.05). The osteogenic gene Runx2 presented high expression levels for TiNbZrTa at day 7, compared to the control group (TiAlV day 3). At day 14, all scaffolds had more than 2-fold induction for Runx2 mRNA levels, with statistically significant differences compared to the control group. Even though we were not able to confirm statistically significant differences to justify the replacement of TiAlV regarding antioxidant enzymes, TiNbZrTa was able to induce faster bone formation at early time points, making it a good choice for biomedical and tissue bioengineering applications.

研究方向是生产新型钛合金,旨在未来替代Ti-6铝-4钒(TiAlV)合金。许多与生物相容性和化学特性相关的机制已经在种植领域得到了研究,但酶对氧化应激的防御仍未得到充分的探索。骨髓基质细胞作为细胞的来源,具有向成骨细胞分化的潜力,可作为细胞治疗的基础。本研究旨在评价Ti-6铝-4钒(TiAlV)、Ti-35铌(TiNb)和Ti-35铌-7锆-5钽(TiNbZrTa)多孔支架对小鼠骨髓基质细胞的抗氧化酶超氧化物歧化酶(SOD)和过氧化氢酶(CAT)活性。采用粉末冶金法制备多孔钛合金支架。24h后,对支架上的细胞进行扫描电镜(SEM)分析。细胞镀后72h测定抗氧化酶活性。3、7、14天后进行实时荧光定量PCR (qRT-PCR)检测,检测Runx2 (runt相关转录因子2)表达情况。扫描电镜(SEM)显示,3种支架均存在相互连接的孔隙和生长、粘附、细胞扩散。各支架间SOD、CAT活性虽有差异,但差异无统计学意义(p > 0.05)。与对照组(TiAlV第3天)相比,成骨基因Runx2在第7天呈现高表达水平。在第14天,所有支架的Runx2 mRNA水平均诱导2倍以上,与对照组相比差异有统计学意义。尽管在抗氧化酶方面,我们无法证实统计学上的显著差异来证明替代TiAlV的合理性,但TiNbZrTa能够在早期时间点诱导更快的骨形成,使其成为生物医学和组织生物工程应用的良好选择。
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引用次数: 2
Physical and Tensile Properties of Handmade Sida rhombifolia Paper. 手工司达双叶桦纸的物理和拉伸性能。
IF 3.1 Q3 MATERIALS SCIENCE, BIOMATERIALS Pub Date : 2020-07-14 eCollection Date: 2020-01-01 DOI: 10.1155/2020/3967641
P W Huisken Mejouyo, E Dydimus Nkemaja, O R Beching, N R Sikame Tagne, T Kana'a, E Njeugna

This study focuses on the production and characterization of biodegradable handmade paper from the Sida rhombifolia plant (SRP) cellulose. Sida rhombifolia plant is a seasonal plant that grows in the equatorial and tropical climates. The studies carried out on this SRP were aimed at investigating the methods required for the production of handmade paper from SRP plant and also at determining the tensile strength. Four specimens of SRP paper of different additive labels S0 (no additive), S1 (starch and KOH), S2 (starch), and S3 (Foska liquid glue) were produced using the Kraft method. Tensile properties (stress at break, elongation at break, and Young's modulus), the rate of water absorption, and the rate of moisture absorption were carried out. Results showed that the addition of potassium hydroxide considerably reduces Young's modulus of SRP handmade paper (S1) while the Foska liquid glue (S3) significantly improves it. In addition, the addition of potassium hydroxide and Foska liquid substantially improves the water absorption properties of the paper S2 and S3, respectively. The adhesive liquid creates more porosity and consequently increases the absorption of water. The addition of potassium hydroxide and Foska liquid significantly embedded the rate of moisture absorption. From the results obtained, it can be concluded that the paper S3 can be used as packaging paper since it has better mechanical properties and moisture absorption.

本研究主要研究了以西达双歧树(SRP)纤维素为原料的可生物降解手工纸的生产和表征。白玉兰是一种生长在赤道和热带气候中的季节性植物。对该SRP进行的研究旨在调查SRP工厂生产手工纸所需的方法,并确定抗拉强度。采用Kraft法制备了4种不同添加剂标签的SRP纸样品,分别为S0(无添加剂)、S1(淀粉和KOH)、S2(淀粉)和S3 (Foska液胶)。拉伸性能(断裂应力、断裂伸长率和杨氏模量)、吸水率和吸湿率进行了测试。结果表明,氢氧化钾的加入显著降低了SRP手工纸的杨氏模量(S1),而Foska液体胶(S3)的加入则显著提高了SRP手工纸的杨氏模量。此外,氢氧化钾和Foska液的加入分别显著提高了纸张S2和S3的吸水性能。粘接剂液体产生更多的孔隙,从而增加水的吸收率。氢氧化钾和Foska液的加入显著提高了吸湿率。结果表明,S3纸具有较好的机械性能和吸湿性,可作为包装纸使用。
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引用次数: 7
Comparative Evaluation of Bone Repair with Four Different Bone Substitutes in Critical Size Defects. 四种不同骨替代物修复临界尺寸骨缺损的比较评价。
IF 3.1 Q3 MATERIALS SCIENCE, BIOMATERIALS Pub Date : 2020-05-23 eCollection Date: 2020-01-01 DOI: 10.1155/2020/5182845
Gustavo Grossi-Oliveira, Leonardo P Faverani, Bruno Coelho Mendes, Tárik Ocon Braga Polo, Gabriel Cury Batista Mendes, Valthierre Nunes de Lima, Paulo Domingos Ribeiro Júnior, Roberta Okamoto, Osvaldo Magro-Filho

This study evaluated the osteoconductive potential of four biomaterials used to fill bone defects. For this, 24 male Albino rabbits were submitted to the creation of a bilateral 8 mm calvarial bone defect. The animals were divided into four groups-bovine hydroxyapatite, Bio-Oss® (BIO); Lumina-Bone Porous® (LBP); Bonefill® (BFL); and an alloplastic material, Clonos® (CLN)-and were euthanized at 14 and 40 days. The samples were subjected to histological and histometric analysis for newly formed bone area. Immunohistochemical analysis for Runt-related transcription factor 2 (Runx2), vascular endothelial growth factor (VEGF), and osteocalcin (OC) was performed. After statistical analysis, the CLN group showed greater new bone formation (NB) in both periods analyzed (p < 0.05). At 14 days, the NB showed greater values in BIO in relation to LBP and BFL groups; however, after 40 days, the LBP group surpassed the results of BIO (p < 0.001). The immunostaining showed a decrease in Runx2 intensity in BIO after 40 days, while it increased for LBP (p < 0.05). The CLN showed increased OC compared to the other groups in both periods analyzed (p < 0.05). Therefore, CLN showed the best osteoconductive behavior in critical defects in rabbit calvaria, and BFL showed the lowest osteoconductive property.

本研究评估了四种用于骨缺损填充的生物材料的骨传导潜能。为此,24只雄性白化兔被提交到双侧8毫米颅骨骨缺损的创建。动物分为四组:牛羟基磷灰石,BIO - oss®(BIO);Lumina-Bone Porous®(LBP);Bonefill®(BFL);和同种异体材料Clonos®(CLN),并在第14天和第40天实施安乐死。对新生骨区进行组织学和组织计量学分析。对runt相关转录因子2 (Runx2)、血管内皮生长因子(VEGF)和骨钙素(OC)进行免疫组化分析。经统计学分析,两期CLN组新骨形成(NB)均高于对照组(p < 0.05)。在第14天,与LBP和BFL组相比,BIO组的NB值更高;然而,40天后,LBP组优于BIO组(p < 0.001)。免疫染色显示,40天后BIO组Runx2强度降低,LBP组Runx2强度升高(p < 0.05)。与其他组相比,CLN组在两个时间段均显示OC升高(p < 0.05)。因此,CLN在兔颅骨关键缺损中表现出最好的骨导电性,BFL表现出最低的骨导电性。
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引用次数: 3
Does Modification of Amalgomer with Propolis Alter Its Physicomechanical Properties? An In Vitro Study. 蜂胶改性汞合金会改变其物理力学性能吗?一项体外研究
IF 3.1 Q3 MATERIALS SCIENCE, BIOMATERIALS Pub Date : 2020-05-11 eCollection Date: 2020-01-01 DOI: 10.1155/2020/3180879
Reham M Abdallah, Amr M Abdelghany, Neven S Aref

Objective: To assess if incorporating ethanolic extract of propolis into ceramic-reinforced glass ionomer (Amalgomer CR) might have an influence on its physicomechanical properties.

Materials and methods: Three groups were assessed; group I: Amalgomer CR (control) and two experimental groups (II and III) of propolis added to the liquid of Amalgomer CR with 25 and 50 v/v %, respectively. Evaluation parameters were color stability, compressive strength, microhardness, and surface roughness. Representative specimens of each group were analyzed by Fourier-transform infrared spectroscopy, energy-dispersive X-ray, X-ray diffraction, and scanning electron microscopy. Analysis of variance (ANOVA) was used to compare the results, followed by a Tukey post hoc test (p < 0.05).

Results: Nonsignificant color change for both groups of modified Amalgomer CR. Meanwhile, the two experimental groups exhibited a significant increase in both compressive strength and microhardness. Simultaneously, there was a significant difference in roughness values among groups with the lowest roughness values exhibited by the 50 v/v % propolis concentration.

Conclusions: Modification of Amalgomer CR with 50 v/v % propolis may increase its mechanical properties without compromising its esthetic. Clinical Significance. Modification of Amalgomer CR by 50 v/v % propolis is supposed to be a hopeful restorative material with favorable characteristics.

目的:探讨蜂胶乙醇提取物对陶瓷增强玻璃离子聚合物(汞合金CR)物理力学性能的影响。材料与方法:分为三组;第一组:汞汞合金CR(对照),第二、三组实验组:蜂胶分别以25、50 v/v %加入汞汞合金CR液中。评价参数为颜色稳定性、抗压强度、显微硬度和表面粗糙度。采用傅里叶变换红外光谱、能量色散x射线、x射线衍射、扫描电镜等方法对各组代表性标本进行分析。采用方差分析(ANOVA)对结果进行比较,并进行Tukey事后检验(p < 0.05)。结果:两组改性铬汞合金的颜色变化不明显,同时两组的抗压强度和显微硬度均有显著提高。同时,蜂胶浓度为50 v/v %时粗糙度值最低,各组间粗糙度值差异显著。结论:用50v /v %蜂胶改性铬汞合金可提高其力学性能,但不影响其美观性。临床意义。用50v /v的蜂胶改性汞合金CR是一种具有良好性能的有希望的修复材料。
{"title":"Does Modification of Amalgomer with Propolis Alter Its Physicomechanical Properties? An In Vitro Study.","authors":"Reham M Abdallah,&nbsp;Amr M Abdelghany,&nbsp;Neven S Aref","doi":"10.1155/2020/3180879","DOIUrl":"https://doi.org/10.1155/2020/3180879","url":null,"abstract":"<p><strong>Objective: </strong>To assess if incorporating ethanolic extract of propolis into ceramic-reinforced glass ionomer (Amalgomer CR) might have an influence on its physicomechanical properties.</p><p><strong>Materials and methods: </strong>Three groups were assessed; group I: Amalgomer CR (control) and two experimental groups (II and III) of propolis added to the liquid of Amalgomer CR with 25 and 50 v/v %, respectively. Evaluation parameters were color stability, compressive strength, microhardness, and surface roughness. Representative specimens of each group were analyzed by Fourier-transform infrared spectroscopy, energy-dispersive X-ray, X-ray diffraction, and scanning electron microscopy. Analysis of variance (ANOVA) was used to compare the results, followed by a Tukey post hoc test (<i>p</i> < 0.05).</p><p><strong>Results: </strong>Nonsignificant color change for both groups of modified Amalgomer CR. Meanwhile, the two experimental groups exhibited a significant increase in both compressive strength and microhardness. Simultaneously, there was a significant difference in roughness values among groups with the lowest roughness values exhibited by the 50 v/v % propolis concentration.</p><p><strong>Conclusions: </strong>Modification of Amalgomer CR with 50 v/v % propolis may increase its mechanical properties without compromising its esthetic. <i>Clinical Significance</i>. Modification of Amalgomer CR by 50 v/v % propolis is supposed to be a hopeful restorative material with favorable characteristics.</p>","PeriodicalId":13704,"journal":{"name":"International Journal of Biomaterials","volume":"2020 ","pages":"3180879"},"PeriodicalIF":3.1,"publicationDate":"2020-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/3180879","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37976500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Synthesis of Silica-Coated Fe3O4 Nanoparticles by Microemulsion Method: Characterization and Evaluation of Antimicrobial Activity. 微乳液法制备二氧化硅包覆的纳米Fe3O4:表征及抗菌活性评价。
IF 3.1 Q3 MATERIALS SCIENCE, BIOMATERIALS Pub Date : 2020-04-12 eCollection Date: 2020-01-01 DOI: 10.1155/2020/4783612
Goshu Asab, Enyew Amare Zereffa, Teshome Abdo Seghne

Magnetite and silica-coated magnetite (Fe3O4) nanoparticles (NPs) were synthesized by water-in-oil (W/O) microemulsion method from hydrated ferric nitrate, ferrous sulfate precursors and ammonia a precipitating agent with the assistance of Tween-80 and SDS surfactants. The synthesized materials were characterized by X-ray diffraction, scanning electron microscopy, thermal analyzer, and infrared spectroscopy. X-ray diffraction pattern of Fe3O4 showed that particles were phase pure with a cubic inverse spinel structure and FT-infrared spectra confirmed the presence of Fe-O bond in tetrahedral and octahedral interstitial sites. The crystallite size determined from powder XRD data with Scherer's equation was in the range of 7.3 ± 0.05 nm-10.83 ± 0.02 nm for uncoated Fe3O4 and 16 ± 0.14 nm for silica-coated Fe3O4 NPs. The SEM micrographs of the uncoated Fe3O4 oxide revealed the agglomeration of the magnetite (Fe3O4) particles. But the silica-coated Fe3O4 oxide exhibited homogeneous distribution of particles with relatively less agglomerate of the particles. The particle size of Fe3O4 NPs slightly increased with the temperature and precursor concentration. The antimicrobial activities of Fe3O4 and silica-coated Fe3O4 nanoparticles were tested against Gram-negative (Escherichia coli and Pseudomonas aeruginosa) and Gram-positive (Staphylococcus aureus and Bacillus subtilis) bacteria. Both Fe3O4 and silica-coated Fe3O4 NPs demonstrated better antimicrobial activities.

以水合硝酸铁、硫酸亚铁前驱体和沉淀剂氨为原料,在Tween-80和SDS表面活性剂的辅助下,采用油包水(W/O)微乳液法制备了磁铁矿和二氧化硅包覆磁铁矿(Fe3O4)纳米颗粒(NPs)。通过x射线衍射、扫描电镜、热分析仪和红外光谱对合成材料进行了表征。Fe3O4的x射线衍射图表明,颗粒物相纯净,具有立方反尖晶石结构,ft -红外光谱证实在四面体和八面体间隙位置存在Fe-O键。采用Scherer方程测定的粉末XRD数据表明,未包覆Fe3O4的晶粒尺寸为7.3±0.05 nm ~ 10.83±0.02 nm,包覆二氧化硅的Fe3O4 NPs的晶粒尺寸为16±0.14 nm。未包覆的Fe3O4氧化物的SEM显微照片显示了磁铁矿(Fe3O4)颗粒的团聚。而二氧化硅包覆的氧化三铁颗粒分布均匀,颗粒结块相对较少。Fe3O4 NPs的粒径随温度和前驱体浓度的增加而略有增加。研究了二氧化硅包覆的Fe3O4纳米颗粒对革兰氏阴性菌(大肠杆菌和铜绿假单胞菌)和革兰氏阳性菌(金黄色葡萄球菌和枯草芽孢杆菌)的抑菌活性。Fe3O4和二氧化硅包覆的Fe3O4 NPs均表现出较好的抗菌活性。
{"title":"Synthesis of Silica-Coated Fe<sub>3</sub>O<sub>4</sub> Nanoparticles by Microemulsion Method: Characterization and Evaluation of Antimicrobial Activity.","authors":"Goshu Asab,&nbsp;Enyew Amare Zereffa,&nbsp;Teshome Abdo Seghne","doi":"10.1155/2020/4783612","DOIUrl":"https://doi.org/10.1155/2020/4783612","url":null,"abstract":"<p><p>Magnetite and silica-coated magnetite (Fe<sub>3</sub>O<sub>4</sub>) nanoparticles (NPs) were synthesized by water-in-oil (W/O) microemulsion method from hydrated ferric nitrate, ferrous sulfate precursors and ammonia a precipitating agent with the assistance of Tween-80 and SDS surfactants. The synthesized materials were characterized by X-ray diffraction, scanning electron microscopy, thermal analyzer, and infrared spectroscopy. X-ray diffraction pattern of Fe<sub>3</sub>O<sub>4</sub> showed that particles were phase pure with a cubic inverse spinel structure and FT-infrared spectra confirmed the presence of Fe-O bond in tetrahedral and octahedral interstitial sites. The crystallite size determined from powder XRD data with Scherer's equation was in the range of 7.3 ± 0.05 nm-10.83 ± 0.02 nm for uncoated Fe<sub>3</sub>O<sub>4</sub> and 16 ± 0.14 nm for silica-coated Fe<sub>3</sub>O<sub>4</sub> NPs. The SEM micrographs of the uncoated Fe<sub>3</sub>O<sub>4</sub> oxide revealed the agglomeration of the magnetite (Fe<sub>3</sub>O<sub>4</sub>) particles. But the silica-coated Fe<sub>3</sub>O<sub>4</sub> oxide exhibited homogeneous distribution of particles with relatively less agglomerate of the particles. The particle size of Fe<sub>3</sub>O<sub>4</sub> NPs slightly increased with the temperature and precursor concentration. The antimicrobial activities of Fe<sub>3</sub>O<sub>4</sub> and silica-coated Fe<sub>3</sub>O<sub>4</sub> nanoparticles were tested against Gram-negative (<i>Escherichia coli</i> and <i>Pseudomonas aeruginosa</i>) and Gram-positive (<i>Staphylococcus aureus</i> and <i>Bacillus subtilis</i>) bacteria. Both Fe<sub>3</sub>O<sub>4</sub> and silica-coated Fe<sub>3</sub>O<sub>4</sub> NPs demonstrated better antimicrobial activities.</p>","PeriodicalId":13704,"journal":{"name":"International Journal of Biomaterials","volume":"2020 ","pages":"4783612"},"PeriodicalIF":3.1,"publicationDate":"2020-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2020/4783612","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37851283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 65
Osteopromotion Capacity of Bovine Cortical Membranes in Critical Defects of Rat Calvaria: Histological and Immunohistochemical Analysis. 牛皮质膜在大鼠颅骨严重缺损中的骨促进能力:组织学和免疫组织化学分析。
IF 3.1 Q3 MATERIALS SCIENCE, BIOMATERIALS Pub Date : 2020-02-18 eCollection Date: 2020-01-01 DOI: 10.1155/2020/6426702
Carolina Ferrairo Danieletto-Zanna, Vinícius Ferreira Bizelli, Guilherme André Del Arco Ramires, Tamires Melo Francatti, Paulo Sérgio Perri de Carvalho, Ana Paula Farnezi Bassi

Membranes that aid the guided bone regeneration (GBR) process have been the subject of studies of compatible biomaterials that contribute to this repair process. The present study compared different membranes used in critical-size defects of rat calvaria by assessing GBR as well as histological, histomorphometric, and immunohistochemical reactions. Forty-eight male albino Wistar rats were randomly allocated into four groups (n = 12 each), namely, C: membrane-free control group (only blood clot, negative control group); BG: porcine collagen membrane group (Bio-Gide®, positive control group); GD: bovine cortical membrane group (first experimental group); and GDF: thicker bovine cortical membrane group (second experimental group). Rats were euthanized at 30 and 60 days postoperatively. Quantitative data from the histometric analysis were submitted to two-way ANOVA and Tukey's posttest when p < 0.05. Histomorphometric results of the thicker bovine cortical membrane at 30 and 60 days were promising, showing improved new bone formation values (p < 0.05), and the CD group presented similar results in both analysis periods, being surpassed only by the GDF group (p < 0.05). The immunohistochemical results were associated with the histomorphometric data. A less-thick membrane also assisted in GBR. All membranes promoted GBR, especially the positive control and experimental groups.

有助于引导骨再生(GBR)过程的膜一直是促进这一修复过程的相容性生物材料研究的主题。本研究通过评估GBR以及组织学、组织形态计量学和免疫组织化学反应,比较了用于大鼠颅骨临界尺寸缺陷的不同膜。48只雄性白化Wistar大鼠随机分为4组,每组n = 12,即C:无膜对照组(仅血凝块,阴性对照组);BG:猪胶原膜组(Bio-Gide®,阳性对照组);GD:牛皮质膜组(第一实验组);GDF:较厚牛皮质膜组(第二实验组)。大鼠分别于术后30天和60天实施安乐死。组织计量分析的定量数据在p < 0.05时采用双向方差分析和Tukey后验。较厚的牛皮质膜在第30天和第60天的组织形态测量结果是有希望的,显示出更好的新骨形成值(p < 0.05), CD组在两个分析周期的结果相似,仅GDF组超过(p < 0.05)。免疫组化结果与组织形态学数据相关联。较薄的膜也有助于GBR。所有膜均促进GBR,尤其是阳性对照组和实验组。
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引用次数: 12
Potentials of Biochars Derived from Bamboo Leaf Biomass as Energy Sources: Effect of Temperature and Time of Heating. 竹叶生物质生物炭作为能源的潜力:温度和加热时间的影响。
IF 3.1 Q3 MATERIALS SCIENCE, BIOMATERIALS Pub Date : 2019-12-14 eCollection Date: 2019-01-01 DOI: 10.1155/2019/3526145
Bidayatul Armynah, Dahlang Tahir, Monalisa Tandilayuk, Zuryati Djafar, Wahyu H Piarah

Biochars from bamboo leaves as a potential energy resource were synthesized by annealing in the oxygen-free environment. Samples were characterized using proximate analysis, Fourier-transform infrared (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), and energy-dispersive spectroscopy (EDS). Heating temperatures are 250°C, 300°C, and 350°C and for each temperature, the time was varied between 30, 60, and 90 minutes. The heating time for 30 minutes results in FC 30.777% and calorific value 15 MJ/Kg at temperature 250°C and decreased to 4.004% and 6 MJ/Kg at temperature 350°C, respectively. EDS shows the time of heating is an important parameter which shows the carbon and nitrogen contents were decreasing with the increase in the heating time, and silicon and oxygen contents were increasing with increase in the heating time. XRD shows broad (002) reflections between 20° and 30°, which indicated disordered carbon with small domains of coherent and parallel stacking of the graphene sheets, which is consistent with surface morphology of the SEM image. The experimental results indicated that heating at 300°C for 30 minutes is an effective and efficient parameter for fabrication of low-cost carbon from bamboo leaves which is a source of useful energy.

以竹叶为原料,在无氧环境下通过退火法制备了生物炭。采用近似分析、傅里叶变换红外(FTIR)、x射线衍射(XRD)、扫描电镜(SEM)和能量色散光谱(EDS)对样品进行了表征。加热温度为250°C、300°C和350°C,每种温度下,时间在30分钟、60分钟和90分钟之间变化。加热30分钟,温度为250℃时FC为30.777%,热值为15 MJ/Kg,温度为350℃时FC为4.004%,热值为6 MJ/Kg。能谱分析表明,加热时间是一个重要的参数,随着加热时间的延长,碳、氮含量逐渐减少,硅、氧含量逐渐增加。XRD在20°~ 30°范围内显示出宽的(002)反射,表明石墨烯片具有小域的相干和平行堆叠,这与SEM图像的表面形貌一致。实验结果表明,在300℃下加热30分钟是竹叶制备低成本碳的有效参数,竹叶是一种有用的能源。
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引用次数: 21
Indigo Carmine and 2,6-Dichlorophenolindophenol Removal Using Cetyltrimethylammonium Bromide-Modified Palm Oil Fiber: Adsorption Isotherms and Mass Transfer Kinetics. 十六烷基三甲基溴化铵改性棕榈油纤维去除靛蓝胭脂红和2,6-二氯酚:吸附等温线和传质动力学。
IF 3.1 Q3 MATERIALS SCIENCE, BIOMATERIALS Pub Date : 2019-12-13 eCollection Date: 2019-01-01 DOI: 10.1155/2019/6862825
Marcel Cédric Deussi Ngaha, Evangéline Njanja, Giscard Doungmo, Arnaud Tamo Kamdem, Ignas Kenfack Tonle

In the present work, the usefulness of cetyltrimethylammonium bromide-modified palm oil fiber (CTAB-modified POF) for the removal of indigo carmine (IC) and 2,6-dichlorophenolindophenol (2,6-DCPIP) from aqueous solutions was investigated. Raw, NaOH-treated, and CTAB-modified POF were characterized by Fourier-transform infrared (FT-IR) spectroscopy, elemental analysis, thermogravimetric-hyperdifferential scanning calorimetric (TG-HDSC) analysis, X-ray diffraction (XRD), and scanning electron microscopy (SEM). The adsorption studies of IC and 2,6-DCPIP were performed in batch mode using CTAB-modified POF. The results showed that equilibrium was attained after a contact time of 30 minutes for IC and 20 minutes for 2,6-DCPIP. The maximum capacity of adsorption was obtained at pH = 2. The capacity of adsorption considerably increased with modified biosorbents and with increasing initial concentration of dyes. The ionic strength favors the increasing adsorption capacity of IC and does not affect the adsorption capacity of 2,6-DCPIP. The percentage of adsorption increased with increasing mass of the biosorbents. The nonlinear regression of adsorption isotherms showed that Freundlich (r 2 = 0.953; χ 2 = 4.398) and Temkin (r 2 = 0.986; χ 2 = 1.196) isotherms are most appropriate to describe the adsorption of IC and 2,6-DCPIP on CTAB-modified POF, respectively. The maximum adsorption capacities determined by the Langmuir isotherm were 275.426 and 230.423 μmol·g-1 for IC and 2,6-DCPIP, respectively. The linear regression of adsorption kinetics was best described by the pseudo-second-order model (R 2 ≥ 0.998). The diffusion mechanism showed that external mass transfer is the main rate controlling step. Desorption of the two dyes is favorable in the alkaline medium.

本文研究了十六烷基三甲基溴化铵改性棕榈油纤维(ctab -改性POF)对水中靛蓝胭脂红(IC)和2,6-二氯酚吲哚酚(2,6- dcpip)的去除效果。采用傅里叶变换红外(FT-IR)光谱、元素分析、热重-高差扫描量热(TG-HDSC)分析、x射线衍射(XRD)和扫描电子显微镜(SEM)对未经加工、naoh处理和ctab改性的POF进行了表征。采用ctab改性POF对IC和2,6- dcpip进行了批量吸附研究。结果表明,IC的接触时间为30分钟,2,6- dcpip的接触时间为20分钟,达到了平衡。pH = 2时吸附量最大。随着改性的生物吸附剂和染料初始浓度的增加,吸附能力显著提高。离子强度有利于提高IC的吸附容量,不影响2,6- dcpip的吸附容量。吸附率随生物吸附剂质量的增加而增加。吸附等温线的非线性回归表明:Freundlich (r 2 = 0.953;χ 2 = 4.398)和Temkin (r 2 = 0.986;χ 2 = 1.196)等温线最适合描述IC和2,6- dcpip在ctab修饰的POF上的吸附。通过Langmuir等温线测定,IC和2,6- dcpip的最大吸附量分别为275.426和230.423 μmol·g-1。拟二阶模型最能描述吸附动力学的线性回归(r2≥0.998)。扩散机理表明,外传质是主要的速率控制步骤。这两种染料在碱性介质中有利于解吸。
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引用次数: 11
Modulus of Elasticity of Two Ceramic Materials and Stress-Inducing Mechanical Deformation following Fabrication Techniques and Adhesive Cementation Procedures of a Dental Ceramic. 两种陶瓷材料的弹性模量以及牙科陶瓷的制造技术和粘接固结程序导致的应力诱发机械变形。
IF 3 Q3 MATERIALS SCIENCE, BIOMATERIALS Pub Date : 2019-11-19 eCollection Date: 2019-01-01 DOI: 10.1155/2019/4325845
G Isgrò, D Rodi, A Sachs, M Hashimoto

Statement of problem: Fabrication technique, precementation, and cementation operative procedures can induce significant modification of the stressing patterns throughout the thickness of some classes of dental ceramic materials.

Objectives: To estimate, by means of the deflection test, residual stress in restorative dental ceramic following fabrication technique, precementation, and resin cement coating procedures and to relate it to the elastic property of the ceramic material tested.

Materials and methods: From IPS e.max® Press, lithium disilicate heat-pressed glass-ceramic (elastic modulus of 95 ± 5 GPa) disc-shaped specimens (n = 10) were made according to the manufacturer's instructions. One surface of the specimens was polished to provide accurate baseline profilometric measurements (reference surface). Deflection measurements were performed after polishing and annealing alumina air-particle abrasion of the unpolished surface followed by resin cement coating of the alumina air-particle abraded surface. The specimens were reprofiled at 24, 48, and 168 hrs after coating. The Friedman test followed by Dunn's multiple comparison test was employed to identify significant differences (p < 0.05). To compare the difference in mean of maximum mechanical deflection, after cement coating at 0 hr, between two different ceramic materials (IPS e.max Press and Vitadur Alpha (result from another study)), Student's t-test for unpaired data was performed.

Results: Baseline profilometric measurements identified a convex form on the polished surface of the ceramic discs with a mean of maximum mechanical deflection of 4.45 ± 0.87 μm. A significant reduction in convexity of the polished specimens was characterized after alumina air-particle abrasion of the unpolished surface. The mean deflection significantly increased after resin cement coating and did not change over the time investigated.

Conclusions: The precementation treatment, namely, alumina air-particle abrasion and cementation procedure of IPS e.max® Press glass-ceramic disc-shaped specimens generates stress that induced mechanical deformation. However, a dental ceramic material with higher elastic modulus (stiffer) would minimize stress-inducing mechanical deformation.

问题陈述:制作技术、预固化和粘接操作程序会导致某些类别的牙科陶瓷材料在整个厚度上的应力模式发生显著变化:目的:通过挠度测试估算牙科陶瓷修复体在经过制作技术、预处理和树脂粘结剂涂层程序后的残余应力,并将其与受测陶瓷材料的弹性属性联系起来:根据制造商的说明,用 IPS e.max® Press 制作二硅酸锂热压玻璃陶瓷(弹性模量为 95 ± 5 GPa)圆盘状试样(n = 10)。对试样的一个表面进行抛光,以提供精确的基线轮廓测量(参考表面)。在对未抛光表面进行抛光和退火氧化铝气粒研磨后,再对氧化铝气粒研磨表面进行树脂胶结涂层,然后进行挠度测量。在涂覆后的 24、48 和 168 小时对试样进行重新测定。采用弗里德曼检验和邓恩多重比较检验来确定显著差异(P < 0.05)。为了比较两种不同陶瓷材料(IPS e.max Press 和 Vitadur Alpha(另一项研究结果))在 0 小时涂水泥后最大机械挠度平均值的差异,对非配对数据进行了学生 t 检验:基线轮廓测量结果表明,陶瓷盘抛光表面呈凸形,最大机械偏差平均值为 4.45 ± 0.87 μm。氧化铝气粒磨蚀未抛光表面后,抛光试样的凸度明显减小。涂抹树脂水泥后,平均挠度明显增加,但在调查时间内没有变化:对 IPS e.max® Press 玻璃陶瓷圆盘形试样进行预固化处理,即氧化铝空气颗粒磨蚀和粘结程序,会产生应力,从而引起机械变形。然而,弹性模量较高(较硬)的牙科陶瓷材料可最大限度地减少应力引起的机械变形。
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引用次数: 0
期刊
International Journal of Biomaterials
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