International Journal of Biomaterials最新文献

SPR-based technology has emerged as one of the most versatile optical tools for analyzing the binding mechanism of molecular interaction due to its inherent advantages in sensing applications, such as real-time, label-free, and high sensitivity characteristics. SPR is widely used in various fields, including healthcare, environmental management, and food-borne illness analysis. Meanwhile, kidney disease has grown to be one of the world's most serious public health problems in recent decades, resulting in physical degeneration and even death. As a result, several studies have published their findings regarding developing of reliable sensor technology based on the SPR phenomenon. However, an integrated and comprehensive discussion regarding the application of SPR-based sensors for detecting of kidney disease has not yet been found. Therefore, this review will discuss the recent advancements in the development of SPR-based sensors for monitoring kidney-related diseases. Numerous SPR configurations will be discussed, including Kretschmann, Otto, optical fiber-based SPR, and LSPR, which are all used to detect analytes associated with kidney disease, including urea, creatinine, glucose, uric acid, and dopamine. This review aims to show the broad application of SPR sensors which encouraged the development of SPR sensors for kidney problems monitoring.

Maxillofacial prostheses are used in rehabilitation of patients with facial defects. Typically, these prostheses are fabricated with medical grade silicone and are tinted corresponding to the patients' natural skin color. However, exposure to environment and disinfectants can result in color changes. This study aimed to evaluate the effects of four different disinfection methods on the color stability of precolored and hand-colored maxillofacial silicones. Forty specimens each of precolored and hand-colored silicone were prepared. The specimens were randomly divided into eight groups (n = 10) and cleansed with four different disinfection methods. Disinfection was carried out six times/day for 60 days, simulating once-a-day disinfection for a year. Color evaluation was carried out at day 0 and day 60 using a UV-vis spectrophotometer. Color alterations were calculated by the CIE L ^∗ a ^∗ b ^∗ system. Data were analyzed by two-way ANOVA with post hoc Tukey HSD and t-tests (α = 0.05). Disinfectants can affect the color stability of maxillofacial silicone. In our study, chlorhexidine solution and liquid soap resulted in the highest color change. Precolored silicone showed higher color stability than its hand-colored counterpart.

The growing use of biomaterials with different therapeutic purposes increases the need for their physiological understanding as well as to seek its integration with the human body. Chronic inflammatory local pathologies, generally associated with infectious or autoimmunity processes, have been a current therapeutic target due to the difficulty in their treatment. The recent development of biomaterials with immunomodulatory capacity would then become one of the possible strategies for their management in local pathologies, by intervening in situ, without generating alterations in the systemic immune response. The treatment of periodontal disease as an inflammatory entity has involved the use of different approaches and biomaterials. There is no conclusive, high evidence about the use of these biomaterials in the regeneration of periodontitis sequelae, so the profession keeps looking for other different strategies. The use of biomaterials with immunomodulatory properties could be one, with a promising future. This review of the literature summarizes the scientific evidence about biomaterials used in the treatment of periodontal disease.

The appropriate capability of handling several forces exerted inside the mouth, and preventing the adhesion and proliferation of oral microorganisms are among the most vital factors for achieving effective alternative dental materials to the damaged native. Nevertheless, lack of mechanical and antimicrobial properties of dental resins hinders their use in most clinical applications in dentistry. In the present study, the main aim was to provide bioepoxy composite biomaterials that could meet the required mechanical and antibacterial properties for dental related fields. Herein, highly biocompatible epoxy and hybrid reinforcing materials were utilised to produce a composite material, which could have features resembling those of original dental parts. Various weight fractions of nanosilver/nano-alumina particles at 1, 2, and 3 wt% were incorporated into the bioepoxy for improving the mechanical and antibacterial characteristics of the biocompatible epoxy resin. Three-point bending and Izod impact tests were performed to evaluate the flexure and impact strengths of the obtained nanocomposites. The morphology of pristine bioepoxy and nanoparticle reinforced bioepoxy composites was characterized by scanning electron microscopy. The influence of these fillers on the bioepoxy resin antibacterial sensitivity was assessed using the agar diffusion technique. Nanofiller contents have been revealed to have a remarkable role to play in tuning the mechanical properties of the nanocomposites; the flexure strength and modulus were higher when the total ratio of hybrid reinforcement was 2 wt%. In contrast, the addition of higher percentage of hybrid nanoparticles could cause deterioration in the flexure characteristics of nanocomposites, yet they were better than those of pristine epoxy. Regarding the impact strength, the enhancement in this property was only observed for the composite containing 1 wt% of AgNps-Al₂O₃; the impact strength was dropped gradually beyond this ratio. The antibacterial effectiveness of the nanocomposites was demonstrated to positively depend on the increase in AgNps mass fraction. Among all evaluated unmodified and modified bioepoxy, the nanocomposite containing 2.5 wt% of AgNps had the higher antibacterial activity against Escherichia coli and Staphylococcus aureus. Based on the attainable outcomes, the prepared composites, particularly at moderate levels of Al₂O₃-AgNps, could provide biocomposites having the potential to be utilised in several biomedical fields, particularly in dental technology.