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Comparative Effect of Incorporation of ZrO2, TiO2, and SiO2 Nanoparticles on the Strength and Surface Properties of PMMA Denture Base Material: An In Vitro Study ZrO2、TiO2和SiO2纳米颗粒掺入对PMMA义齿基托材料强度和表面性能的比较研究
IF 3.1 Q3 MATERIALS SCIENCE, BIOMATERIALS Pub Date : 2022-04-28 DOI: 10.1155/2022/5856545
Emad Azmy, M. R. Al-kholy, Ahmad M. Al-Thobity, M. Gad, M. A. Helal
Objective This study aimed to investigate the effects of nanoparticles (zirconium dioxide (ZrO2), titanium dioxide (TiO2), and silicon dioxide (SiO2)) on the flexural strength, impact strength, hardness, and wear resistance of the acrylic resin denture base material. Materials and Methods Acrylic resin specimens were fabricated in dimensions according to American Dental Association (ADA) specifications per test. Specimens were divided according to nanofiller into four groups; unmodified as control, ZrO2 (Z), TiO2, (T), and SiO2 (S) groups. Each one was subdivided into two subgroups according to nanoparticle concentrations; 3% and 7% (Z3, Z7, T3, T7, S3, and S7). A 3-point bending test, Charpy impact test, and Vickers hardness test were used for flexural strength, impact strength, and hardness measurements, respectively. Wear resistance was measured by the differences in surface roughness of tested specimens before and after the wear test. A scanning electron microscope was used to assess nanoparticle specifications and distributions and for fracture surfaces analysis. ANOVA, Bonferroni's post hoc test, and the Kruskal–Wallis test were applied for data analysis (α = 0.05). Results Regarding the flexural and impact strength, there was a statistically remarkable increase for all tested groups compared with the control group, except for the T7 and S7 groups (P value <0.001, effect size = 0.893) and (P value <0.001, effect size = 0.759), respectively. There was a statistically significant improvement in the hardness of all tested groups compared with the control group (P value <0.001, effect size = 0.67) except T3 and S3. Regarding wear, a statistically significant enhancement was noticed in the wear resistance of all tested groups (P value <0.001, effect size = 0.685), except for the T7 and S7 groups. Conclusion The flexural strength, impact strength, and wear resistance improved with both concentrations of ZrO2 and low TiO2 and SiO2 concentrations. The hardness increased with both concentrations of ZrO2 and high TiO2 and SiO2 concentrations.
目的研究纳米二氧化锆(ZrO2)、二氧化钛(TiO2)和二氧化硅(SiO2)对丙烯酸树脂义齿基托材料抗弯强度、冲击强度、硬度和耐磨性的影响。材料和方法根据美国牙科协会(ADA)每次试验的规格尺寸制作丙烯酸树脂样品。根据纳米填料的不同,将标本分为四组;作为对照,ZrO2 (Z), TiO2, (T)和SiO2 (S)基团。根据纳米颗粒浓度,每组又分为两个亚组;3%和7% (Z3, Z7, T3, T7, S3和S7)。弯曲强度、冲击强度和硬度测量分别采用三点弯曲试验、夏比冲击试验和维氏硬度试验。通过磨损试验前后试样表面粗糙度的差异来测定耐磨性。使用扫描电子显微镜评估纳米颗粒的规格和分布,并进行断口分析。数据分析采用方差分析、Bonferroni事后检验和Kruskal-Wallis检验(α = 0.05)。结果除T7组和S7组(P值<0.001,效应量= 0.893)和(P值<0.001,效应量= 0.759)外,各试验组的抗折和冲击强度均较对照组有显著提高,差异均有统计学意义。除T3、S3组外,各试验组硬度均较对照组有显著提高(P值<0.001,效应量= 0.67)。在磨损方面,除T7和S7组外,所有测试组的耐磨性均有统计学意义的增强(P值<0.001,效应值= 0.685)。结论ZrO2浓度和低TiO2、SiO2浓度均能提高材料的抗弯强度、冲击强度和耐磨性。随着ZrO2浓度的增加以及TiO2和SiO2浓度的增加,材料的硬度均有所增加。
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引用次数: 12
Investigation of CO2 Extract of Portulaca oleracea for Antioxidant Activity from Raw Material Cultivated in Kazakhstan 哈萨克马齿苋CO2萃取物抗氧化活性研究
IF 3.1 Q3 MATERIALS SCIENCE, BIOMATERIALS Pub Date : 2022-04-22 DOI: 10.1155/2022/6478977
Meruyert I Tleubayeva, R. Abdullabekova, U. Datkhayev, M. Ishmuratova, M. Alimzhanova, K. Kozhanova, Aida M. Seitaliyeva, K. Zhakipbekov, Zhanar Iskakova, E. Serikbayeva, E. Flisyuk
Medicinal plants remain as an important resource in the fight against many diseases, especially in developing countries. Antioxidants are substances capable of delaying, retarding, and preventing the oxidation of lipids or substances that delay or prevent free radical reactions during lipid oxidation. Natural antioxidants such as ascorbic acid, tocopherol, phenolic compounds, and flavonoids are a safe alternative to chemical antioxidants. In present work, results of antioxidant activity of raw materials from the cultivated plant Portulaca oleracea are presented. The extraction time was optimized to 780 minutes; the yield of extractive substances was 1.25% in the production of CO2 extract under subcritical conditions. For the first time, the antioxidant activity of Portulaca oleracea CO2 extract was determined by the amperometric method. Gas chromatography-mass spectrometry (GC-MS) chemical analysis of Portulaca oleracea CO2 extract dissolved in hexane revealed 37 components, including a complex mixture of aldehydes, alkanes, alkenes, esters, diterpenes, steroids, vitamin E, and carbohydrates. The investigation results showed that the Portulaca oleracea CO2 extract was promising for pharmaceutical, cosmetic, and food industries and had great potential for the prevention and treatment of diseases caused by oxidative stress.
药用植物仍然是防治许多疾病的重要资源,特别是在发展中国家。抗氧化剂是能够延缓、延缓和防止脂质氧化的物质,或者是在脂质氧化过程中延缓或防止自由基反应的物质。抗坏血酸、生育酚、酚类化合物和类黄酮等天然抗氧化剂是化学抗氧化剂的安全替代品。本文对马齿苋原料的抗氧化活性进行了研究。优化提取时间为780 min;在亚临界条件下生产CO2萃取物,萃取物得率为1.25%。首次采用安培法测定马齿苋CO2提取物的抗氧化活性。气相色谱-质谱联用(GC-MS)对马齿苋CO2萃取物进行化学分析,发现37种成分,包括醛类、烷烃、烯烃、酯类、二萜、类固醇、维生素E和碳水化合物的复杂混合物。研究结果表明,马齿苋CO2提取物在医药、化妆品、食品等行业具有广阔的应用前景,在防治氧化应激引起的疾病方面具有很大的潜力。
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引用次数: 1
Development of Novel Antimicrobial Dental Composite Resin with Nano Cerium Oxide Fillers 纳米氧化铈复合树脂的研制
IF 3.1 Q3 MATERIALS SCIENCE, BIOMATERIALS Pub Date : 2022-04-12 DOI: 10.1155/2022/3912290
E. Varghese, Dhanasekaran Sihivahanan, K. Venkatesh
Objectives To assess the antibacterial efficacy of experimental dental composite resin with cerium oxide nanoparticles as fillers. Methods The cerium oxide nanoparticles were prepared by the coprecipitation procedure. Synthesized 3wt% CeO2 nanoparticles were added to the composite resin as antibacterial filler. Experimental composite resin was manually prepared by adding ingredients. The resin matrix consisted of two mixed monomers, bisphenol A-glycidyl methacrylate and triethylene glycol dimethacrylate, diketone as the photo initiator, and N, N-dimethylaminoethyl methacrylate as a coinitiator. The antibacterial efficacy against Streptococcus mutans, Streptococcus mitis, Streptococcus aureus, and Lactobacillus spp. bacterial strains was tested using the microdilution method keeping commercially available 3M Filtek Z250 restorative composite as control. Results The experimental dental composite demonstrated 99.503% efficacy against Streptococcus mutans, 99.441% efficacy against Streptococcus mitis, 99.416% efficacy against Streptococcus aureus, and 99.233% efficacy against Lactobacillus spp. Conclusion Integrating cerium oxide nanoparticles as fillers into dental composite resin can be promising in terms of antibacterial activity, provided furthermore study has to be conducted to examine other properties. Clinical Significance. Previous studies attempted adding CeO2 nanoparticles into acrylic resins that showed improvement in mechanical properties, but literature is nil on the dental composite resin and cerium oxide nanoparticles. This study demonstrates the development of an experimental antibacterial dental composite resin that can resolve most of the problems related to secondary caries around dental composite restorations.
目的评价氧化铈纳米颗粒填充牙用复合树脂的抗菌效果。方法采用共沉淀法制备氧化铈纳米颗粒。将合成的3wt% CeO2纳米颗粒作为抗菌填料加入到复合树脂中。通过添加原料手工制备实验用复合树脂。树脂基体由两种混合单体组成,双酚a -甲基丙烯酸甘油酯和三甘醇二甲基丙烯酸酯,二酮为光引发剂,N, N-二甲氨基乙基甲基丙烯酸酯为助引发剂。以市售的3M Filtek Z250恢复性复合材料为对照,采用微量稀释法检测对变形链球菌、炎链球菌、金黄色链球菌和乳杆菌菌株的抑菌效果。结果该口腔复合材料对变形链球菌的抗菌效果为99.503%,对螨虫链球菌的抗菌效果为99.441%,对金黄色链球菌的抗菌效果为99.416%,对乳酸菌的抗菌效果为99.233%。结论将氧化铈纳米颗粒作为填充剂应用于口腔复合树脂中,具有良好的抗菌活性,其他性能有待进一步研究。临床意义。先前的研究尝试在丙烯酸树脂中加入CeO2纳米颗粒,显示出力学性能的改善,但文献中没有关于牙科复合树脂和氧化铈纳米颗粒的研究。本研究展示了一种实验性抗菌牙科复合树脂的开发,可以解决牙科复合修复体周围继发龋的大部分问题。
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引用次数: 1
Bioconversion of Keratin Wastes Using Keratinolytic Microorganisms to Generate Value-Added Products. 利用角蛋白溶解微生物对角蛋白废料进行生物转化,生产增值产品。
IF 3 Q3 MATERIALS SCIENCE, BIOMATERIALS Pub Date : 2022-03-22 eCollection Date: 2022-01-01 DOI: 10.1155/2022/2048031
Muhammed Seid Anbesaw

The management of keratinous wastes generated from different industries is becoming a major concern across the world. In each year, more than a billion tons of keratin waste is released into the environment. Despite some trials that have been performed and utilize this waste into valuable products, still a huge amount of keratin waste from different sources is a less explored biomaterial for making valuable products. This indicates that the huge amount of keratin waste is neither disposed properly nor converted into usable products rather thrown away to the environment that causes environmental pollution. Due to the introduction of this waste associated with different pathogenic organisms into soil and water bodies, human beings and other small and large animals are affected by different diseases. Therefore, there is a need for modern and ecofriendly approaches to dispose and convert this waste into usable products. Hence, the objective of this review is to give a concise overview regarding the degradation of keratin waste by biological approaches using keratinase producing microorganisms. The review also focuses on the practical use of keratinases and the economical importance of bioconverted products of keratinous wastes for different applications. Various researches have been studied about the source, disposal mechanisms, techniques of hydrolysis, potential use, and physical and chemical properties of keratin wastes. However, there is negligible information with regard to the use of keratin wastes as media supplements for the growth of keratinolytic microorganisms and silver retrieval from photographic and used X-ray films. Hence, this review differs from other similar reviews in the literature in that it discusses these neglected concerns.

管理不同行业产生的角质废料正成为全世界关注的一个主要问题。每年有超过 10 亿吨的角蛋白废物被排放到环境中。尽管已经进行了一些试验,将这些废料转化为有价值的产品,但来自不同来源的大量角蛋白废料仍然是一种较少被开发用于制造有价值产品的生物材料。这表明,大量的角蛋白废料既没有得到妥善处理,也没有转化为可用产品,而是被丢弃到环境中,造成环境污染。由于这些废物与不同的病原生物一起进入土壤和水体,人类和其他大小动物受到不同疾病的影响。因此,有必要采用现代和生态友好的方法来处理这些废物并将其转化为可用产品。因此,本综述旨在简要概述利用产生角蛋白酶的微生物,通过生物方法降解角蛋白废物的情况。综述还重点介绍了角蛋白酶的实际用途,以及角质废料生物转化产品在不同应用领域的经济重要性。关于角蛋白废物的来源、处置机制、水解技术、潜在用途以及物理和化学性质,已经开展了多项研究。然而,关于将角蛋白废料用作角蛋白溶解微生物生长和从照相胶片和用过的 X 射线胶片中提取银的介质补充剂的信息却微乎其微。因此,本综述与其他类似的文献综述不同,它讨论了这些被忽视的问题。
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引用次数: 0
Effectiveness of Combination of Chitosan Gel and Hydroxyapatite from Crabs Shells (Portunus pelagicus) Waste as Bonegraft on Periodontal Network Regeneration through IL-1 and BMP-2 Analysis 白细胞介素1和骨形成蛋白-2分析壳聚糖凝胶和废弃蟹壳羟基磷灰石复合骨痂对牙周网络再生的影响
IF 3.1 Q3 MATERIALS SCIENCE, BIOMATERIALS Pub Date : 2022-03-20 DOI: 10.1155/2022/1817236
Asdar Gani, R. Yulianty, Supiaty Supiaty, Machirah Rusdy, Gustivanny Dwipa Asri, Dian Eka Satya, Ayu Rahayu Feblina, H. Achmad
Background Periodontitis can be treated by regenerating periodontal tissue using a bone graft. Several natural materials such as chitosan and minerals such as hydroxyapatite can be developed to increase periodontal tissue regeneration. Chitosan has a high potential in healing wounds. Hydroxyapatite has excellent properties such as biocompatibility, osteoconductive, osteoinductive, and osteogenesis, making it an ideal material for soft and hard tissue regeneration. Chitosan and hydroxyapatite can be obtained from the shells of crustaceans, such as crabs shells (Portunus pelagicus). Objective To assess the effectiveness of the combination of chitosan gel and hydroxyapatite powder as a bone graft on periodontal tissue regeneration in experimental animals. Periodontal tissue regeneration was assessed by expressing inflammatory cytokine gene indicators IL-1 and BMP-2. Methods Experimental laboratory research and clinical trials with posttest only control group design. Twenty-seven Wistar rats were divided into three groups. Then the femoral bone defect was made, the positive control group was given placebo gel, the positive control group was given BATAN hydroxyapatite, and the test group was given a combination of chitosan gel and hydroxyapatite crab shells. Wistar rats were sacrificed on days 7, 14, and 21, and the femur bone was then taken for immunohistochemical analysis to determine the levels of IL-1 and BMP-2. The Kolmogorov–Smirnov test, Levene test, and one-way ANOVA analyzed the data. Results On days 7, 14, and 21, the expression levels of IL-1 and BMP2 were significantly different between the three groups. The group added with chitosan gel and crab shell HA showed a faster decrease in IL-1 expression than the control group. BMP-2 expression increased in the test group compared to the control group. Conclusion The combination of chitosan gel and hydroxyapatite inhibited the production of proinflammatory cytokines and increased the production of BMP-2.
牙周炎可以通过骨移植再生牙周组织来治疗。几种天然材料,如壳聚糖和矿物质,如羟基磷灰石,可以开发促进牙周组织再生。壳聚糖在伤口愈合方面具有很高的潜力。羟基磷灰石具有生物相容性、骨导电性、骨诱导性和成骨性等优良性能,是软硬组织再生的理想材料。壳聚糖和羟基磷灰石可以从甲壳类动物的壳中获得,如蟹壳(Portunus pelagicus)。目的探讨壳聚糖凝胶与羟基磷灰石粉复合植骨对实验性动物牙周组织再生的影响。通过表达炎症细胞因子基因指标IL-1和BMP-2来评估牙周组织再生。方法采用单纯后测对照组设计,进行实验室实验研究和临床试验。将27只Wistar大鼠分为三组。然后制作股骨缺损,阳性对照组给予安慰剂凝胶,阳性对照组给予巴丹羟基磷灰石,试验组给予壳聚糖凝胶与羟基磷灰石蟹壳的联合治疗。Wistar大鼠于第7、14、21天处死,取股骨进行免疫组化分析,测定IL-1和BMP-2水平。采用Kolmogorov-Smirnov检验、Levene检验和单因素方差分析对数据进行分析。结果在第7、14、21天,三组间IL-1、BMP2的表达水平均有显著差异。壳聚糖凝胶组和蟹壳HA组IL-1表达下降速度明显快于对照组。与对照组相比,试验组BMP-2表达升高。结论壳聚糖凝胶与羟基磷灰石联合使用可抑制促炎细胞因子的产生,增加BMP-2的产生。
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引用次数: 4
Cotton Cellulose-Derived Hydrogel and Electrospun Fiber as Alternative Material for Wound Dressing Application 棉纤维素水凝胶和静电纺丝纤维作为伤口敷料的替代材料
IF 3.1 Q3 MATERIALS SCIENCE, BIOMATERIALS Pub Date : 2022-03-07 DOI: 10.1155/2022/2502658
Supidcha Jirawitchalert, Samon Mitaim, Ching-Yi Chen, N. Patikarnmonthon
Cotton has been recognized as a useful biomaterial over decades, and it has been widely applied in the textile industry. However, a large amount of cotton waste is generated during the manufacturing processes, but it has been considered as a low-value product. With high content of cellulose remaining in cotton waste, our study focuses on transforming cotton cellulose into a valuable product. Cellulose was extracted from cotton waste and modified into two main materials for wound dressing application: hydrogel-based water absorbent materials and electrospun composite nanofibers. In order to enhance the water absorption, carboxymethyl cellulose (CMC), the modified cellulose with functional group prone to interact with water molecules, has been developed in this study. The hydrogel-based CMC was created by using the chemical cross-linking reaction of epichlorohydrin (ECH). The hydrogel demonstrated the swelling and reswelling ability by 1718 ± 137% and 97.95 ± 9.76%, respectively. Meanwhile, cellulose/PEG in trifluoroacetic acid (TFA) was successfully fabricated as nonwoven composite by a conventional electrospinning technique. The fabrics provided highly appropriated properties as wound dressing, including the following: water absorption was up to 1300 times and water vapor permeability controlled in the range of 2163–2285 g·m−2·day−1. This showed the preliminary information for recovering cotton waste into valuable products.
几十年来,棉花作为一种有用的生物材料已被公认,并在纺织工业中得到了广泛的应用。然而,在生产过程中产生了大量的棉花废料,但它一直被认为是低价值产品。由于棉花废料中纤维素的含量很高,我们的研究重点是将棉花纤维素转化为有价值的产品。从废棉中提取纤维素并对其进行改性,制备了两种主要的伤口敷料材料:水凝胶基吸水材料和静电纺复合纳米纤维。为了提高纤维素的吸水性,本研究开发了羧甲基纤维素(carboxymethyl cellulose, CMC),这是一种具有易于与水分子相互作用的官能团的改性纤维素。利用环氧氯丙烷(ECH)的化学交联反应制备了水凝胶基CMC。水凝胶的溶胀性和溶胀性分别为1718±137%和97.95±9.76%。同时,采用静电纺丝技术成功制备了三氟乙酸(TFA)中纤维素/聚乙二醇(PEG)的非织造复合材料。织物具有良好的伤口敷料性能,吸水率可达1300倍,水蒸气渗透性控制在2163-2285 g·m−2·day−1。这为棉废资源化利用提供了初步信息。
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引用次数: 4
A Comparative Evaluation of the Radiopacity of Contemporary Restorative CAD/CAM Blocks Using Digital Radiography Based on the Impact of Material Composition 基于材料组成影响的当代CAD/CAM修复体数字x线摄影放射不透明度的比较评价
IF 3.1 Q3 MATERIALS SCIENCE, BIOMATERIALS Pub Date : 2022-02-21 DOI: 10.1155/2022/4131176
N. Elhelbawy, Rehab F Ghouraba, Fatma A Hasaneen
Purpose The main purpose of this study was to assess the radiopacity of contemporary restorative computer-aided design (CAD)/computer-aided manufacturing (CAM) materials and the impact of material composition as measured by energy-dispersive X-ray spectrophotometry (EDX) on radiopacity. Materials and Methods Ten specimens of six CAD/CAM materials with 1 mm thickness were produced and then digitally radiographed with an aluminum (Al) step-wedge (SW) and 1 mm thick tooth slice. The specimen mean gray values (MGVs) were recorded in pixels and compared to an Al-SW, dentin, and enamel of equal thickness. For the elementary analysis of the composition of the materials, EDX was performed. Results The recorded MGVs ranged between 21.20 ± 4.94 and 238.5 ± 13.61 pixels. Materials were sorted according to the MGVs descendingly, Prettau, Vita Suprinity, Vita Enamic, Shofu, Pekkton, and BioHPP. Prettau and Vita Suprinity had significantly higher MGV than dentin and 1 mm thick Al. In comparison, Vita Enamic had a slightly higher value than dentin and 1 mm thick Al. Although Pekkton and BioHPP had MGV significantly lower than dentin and 1 mm thick Al, Shofu had a significantly lower value than dentin and nonsignificantly lower than 1 mm thick Al (p < 0.05). According to EDX analysis, the examined materials contained several components in varying quantities of radiopacity. Conclusions The radiopacity of only three studied materials exceeded the International Organization for Standardization's minimum standards (ISO).
本研究的主要目的是评估当代恢复性计算机辅助设计(CAD)/计算机辅助制造(CAM)材料的放射不透明度,以及能量色散x射线分光光度法(EDX)测量的材料成分对放射不透明度的影响。材料与方法制作了6种CAD/CAM材料的10个样品,厚度为1mm,然后用铝(Al)阶梯楔(SW)和1mm厚的齿片进行数字x线摄影。以像素为单位记录样品的平均灰度值(MGVs),并与Al-SW、牙本质和等厚度的牙釉质进行比较。对材料的组成进行了初步分析。结果MGVs范围为21.20±4.94 ~ 238.5±13.61。材料按照mgv下降、Prettau、Vita Suprinity、Vita Enamic、Shofu、Pekkton和BioHPP进行分类。Prettau和Vita Suprinity的MGV显著高于牙本质和1 mm厚Al, Vita Enamic的MGV略高于牙本质和1 mm厚Al, Pekkton和BioHPP的MGV显著低于牙本质和1 mm厚Al, Shofu的MGV显著低于牙本质,不显著低于1 mm厚Al (p < 0.05)。根据EDX分析,被检测的材料含有几种不同数量的放射性成分。结论仅有3种材料的放射不透明度超过国际标准化组织(ISO)的最低标准。
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引用次数: 3
Bioactive Cellulose Acetate Electrospun Mats as Scaffolds for Bone Tissue Regeneration. 作为骨组织再生支架的生物活性醋酸纤维素电纺垫。
IF 3 Q3 MATERIALS SCIENCE, BIOMATERIALS Pub Date : 2022-02-04 eCollection Date: 2022-01-01 DOI: 10.1155/2022/3255039
Simara Laboy-López, Pedro O Méndez Fernández, Jorge G Padilla-Zayas, Eduardo Nicolau

In the last decades, cell-based approaches for bone tissue engineering (BTE) have relied on using models that cannot replicate the complexity of the bone microenvironment. There is an ongoing amount of research on scaffold development responding to the need for feasible materials that can mimic the bone extracellular matrix (ECM) and aid bone tissue regeneration (BTR). In this work, a porous cellulose acetate (CA) fiber mat was developed using the electrospinning technique and the mats were chemically modified to bioactivate their surface and promote osteoconduction and osteoinduction. The mats were characterized using FTIR and SEM/EDS to validate the chemical modifications and assess their structural integrity. By coupling adhesive peptides KRSR, RGD, and growth factor BMP-2, the fiber mats were bioactivated, and their induced biological responses were evaluated by employing immunocytochemical (ICC) techniques to study the adhesion, proliferation, and differentiation of premature osteoblast cells (hFOB 1.19). The biological assessment revealed that at short culturing periods of 48 hours and 7 days, the presence of the peptides was significant for proliferation and adhesion, whereas at longer culture times of 14 days, it had no significant effect on differentiation and maturation of the osteogenic progenitor cells. Based on the obtained results, it is thus concluded that the CA porous fiber mats provide a promising surface morphology that is both biocompatible and can be rendered bioactive upon the addition of osteogenic peptides to favor osteoconduction leading to new tissue formation.

过去几十年来,基于细胞的骨组织工程(BTE)方法一直依赖于使用无法复制骨微环境复杂性的模型。为了满足对可模拟骨细胞外基质(ECM)并有助于骨组织再生(BTR)的可行材料的需求,有关支架开发的研究一直在进行。在这项工作中,利用电纺丝技术开发了一种多孔醋酸纤维素(CA)纤维毡,并对纤维毡进行了化学改性,使其表面具有生物活性,促进骨传导和骨诱导。利用傅立叶变换红外光谱和扫描电镜/电子显微镜对纤维毡进行了表征,以验证化学修饰并评估其结构完整性。通过耦合粘附肽 KRSR、RGD 和生长因子 BMP-2,纤维毡被生物活化,并通过免疫细胞化学(ICC)技术评估了其诱导的生物反应,以研究过早成骨细胞(hFOB 1.19)的粘附、增殖和分化。生物学评估显示,在 48 小时和 7 天的短期培养中,多肽的存在对增殖和粘附有显著影响,而在 14 天的长期培养中,多肽对成骨祖细胞的分化和成熟没有显著影响。根据所获得的结果,可以得出结论:CA 多孔纤维毡提供了一种很有前景的表面形态,既具有生物相容性,又能在添加成骨肽后增强生物活性,从而促进骨传导,形成新的组织。
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引用次数: 0
Quantitative Assessment of Apically Extruded Debris after Single-Files Supplemental Retreatment considering Apical Patency Influence: In Vitro Study. 考虑根尖通畅影响的单锉补充再治疗后根尖挤压碎片的定量评估:体外研究。
IF 3.1 Q3 MATERIALS SCIENCE, BIOMATERIALS Pub Date : 2022-01-01 DOI: 10.1155/2022/7544813
Neveen Ali Shaheen, Nahla Gamaleldin Elhelbawy, Dalia Abdelhamid Sherif

Objective: This study aims to assess the impact of re-establishing apical patency on the quantity of debris extruded through the apex after three supplementary retreatment files (TruNatomy (TRN), WaveOne Gold (WOG), and XP endo Finisher R (XPFR)).

Materials and methods: Eighty single-rooted mandibular premolars were prepared with ProTaper Universal rotary systems (PTU) up to F3 and obturated. The samples were divided into two main groups according to the presence or absence of the apical patency (n = 40), GI with apical patency and GII without apical patency. Based on the file system, which was adopted to eliminate the previous filling, each group had four subgroups (n = 10). In GI PTUR and GII PTUR, ProTaper Universal retreatment files (PTUR) were utilized only to remove the most primary filling material (control groups). In the other groups (PTUR) used, it was first followed by supplementary files. The quantity of debris extruded by different retreatment file systems was determined and compared to the corresponding control group with or without apical patency. Data were analyzed using a two-way ANOVA with a post hoc Tukey's multiple comparison test at a 5% significance level.

Results: There was a statistically significant difference among the control and experimental groups. XPFR had the least quantity of extruded debris. Apical patency did not affect the debris extrusion.

Conclusion: All tested files led to a significant apical debris extrusion regardless of apical patency.

目的:本研究旨在评估重建根尖通畅对三种辅助再治疗锉(TruNatomy (TRN), WaveOne Gold (WOG)和XP endo Finisher R (XPFR))后根尖突出碎片数量的影响。材料和方法:用ProTaper通用旋转系统(PTU)制备80颗单根下颌前磨牙,达到F3并封闭。根据有无根尖通畅将样本分为有根尖通畅的GI组和无根尖通畅的GI组(n = 40)。基于消除先前填充所采用的文件系统,每组分为4个子组(n = 10)。在GI PTUR和GII PTUR中,ProTaper通用再处理锉(PTUR)仅用于去除大部分初级填充材料(对照组)。在使用的其他组(PTUR)中,首先是补充文件。测定不同再处理文件系统挤出的碎片数量,并与相应的有或无根尖开放的对照组进行比较。数据分析采用双向方差分析和事后Tukey多重比较检验,显著性水平为5%。结果:对照组与实验组比较,差异有统计学意义。XPFR的挤压碎片数量最少。根尖通畅不影响碎片挤压。结论:无论根尖是否通畅,所有测试的锉都导致了明显的根尖碎片挤压。
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引用次数: 0
Antimicrobial Agents Based on Metal Complexes: Present Situation and Future Prospects. 金属配合物抗菌药物的研究现状与展望
IF 3.1 Q3 MATERIALS SCIENCE, BIOMATERIALS Pub Date : 2022-01-01 DOI: 10.1155/2022/6819080
Bharti Sharma, Sudeep Shukla, Rohit Rattan, Musarrat Fatima, Mayurika Goel, Mamta Bhat, Shruti Dutta, Rakesh Kumar Ranjan, Mamta Sharma

The rise in antimicrobial resistance is a cause of serious concern since the ages. Therefore, a dire need to explore new antimicrobial entities that can combat against the increasing threat of antibiotic resistance is realized. Studies have shown that the activity of the strongest antibiotics has reduced drastically against many microbes such as microfungi and bacteria (Gram-positive and Gram-negative). A ray of hope, however, was witnessed in early 1940s with the development of new drug discovery and use of metal complexes as antibiotics. Many new metal-based drugs were developed from the metal complexes which are potentially active against a number of ailments such as cancer, malaria, and neurodegenerative diseases. Therefore, this review is an attempt to describe the present scenario and future development of metal complexes as antibiotics against wide array of microbes.

抗菌素耐药性的上升自古以来就是一个令人严重关切的问题。因此,迫切需要探索新的抗微生物实体,以对抗日益严重的抗生素耐药性威胁。研究表明,最强抗生素对许多微生物,如微真菌和细菌(革兰氏阳性和革兰氏阴性)的活性急剧下降。然而,在20世纪40年代初,随着新药物的发现和金属配合物作为抗生素的使用,人们看到了一线希望。从金属配合物中开发出许多新的金属基药物,这些药物对癌症、疟疾和神经退行性疾病等许多疾病具有潜在的活性。因此,本文综述了金属配合物作为抗多种微生物抗生素的现状和未来发展。
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引用次数: 6
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International Journal of Biomaterials
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