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Advancements in the Use of Hydrogels for Regenerative Medicine: Properties and Biomedical Applications. 水凝胶在再生医学中的应用进展:性质和生物医学应用。
IF 3.1 Q2 Engineering Pub Date : 2022-11-07 eCollection Date: 2022-01-01 DOI: 10.1155/2022/3606765
Andrea Revete, Andrea Aparicio, Bruno A Cisterna, Javier Revete, Luis Luis, Ernesto Ibarra, Edwin A Segura González, Jay Molino, Diego Reginensi

Due to their particular water absorption capacity, hydrogels are the most widely used scaffolds in biomedical studies to regenerate damaged tissue. Hydrogels can be used in tissue engineering to design scaffolds for three-dimensional cell culture, providing a novel alternative to the traditional two-dimensional cell culture as hydrogels have a three-dimensional biomimetic structure. This material property is crucial in regenerative medicine, especially for the nervous system, since it is a highly complex and delicate structure. Hydrogels can move quickly within the human body without physically disturbing the environment and possess essential biocompatible properties, as well as the ability to form a mimetic scaffold in situ. Therefore, hydrogels are perfect candidates for biomedical applications. Hydrogels represent a potential alternative to regenerating tissue lost after removing a brain tumor and/or brain injuries. This reason presents them as an exciting alternative to highly complex human physiological problems, such as injuries to the central nervous system and neurodegenerative disease.

由于其特殊的吸水能力,水凝胶是生物医学研究中最广泛使用的用于再生受损组织的支架。水凝胶可用于组织工程中设计三维细胞培养支架,为传统的二维细胞培养提供了一种新的选择,因为水凝胶具有三维仿生结构。这种材料特性在再生医学中至关重要,尤其是神经系统,因为它是一个高度复杂和微妙的结构。水凝胶可以在人体内快速移动而不会对环境造成物理干扰,并且具有基本的生物相容性,以及在原位形成模拟支架的能力。因此,水凝胶是生物医学应用的完美候选者。水凝胶是切除脑肿瘤和/或脑损伤后组织再生的潜在替代品。这个原因使它们成为一个令人兴奋的替代高度复杂的人类生理问题,如中枢神经系统损伤和神经退行性疾病。
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引用次数: 10
Zinc Oxide Nanoparticles as Diagnostic Tool for Cancer Cells. 氧化锌纳米颗粒作为癌细胞的诊断工具。
IF 3.1 Q2 Engineering Pub Date : 2022-11-02 eCollection Date: 2022-01-01 DOI: 10.1155/2022/2807644
Sumayah Ibraheem, Afraa Ali Kadhim, Kadhim Ali Kadhim, Ihssan A Kadhim, Majid Jabir

ZnO nanoparticles have various characteristics that make them attractive to be used in many medical applications like a cancer diagnosis. It can be used as a nanoprobe for targeting different types of cancer cells in vitro as a cancer cell recognition system. The present study aims to investigate the permeability of ZnO NPs through both normal and cancerous cell lines in humans. In vitro experiments for ZnO NPs inside the environment of living cells have been described, which would contribute to the visualization of nanoparticles as cancer diagnostic and scanning techniques. MCF7, AMJ13, and RD cancer cells, and also the normal breast cell line HBL, were used in in vitro imaging experiments. The findings revealed that ZnO NPs specifically incorporated within tumor cells while accumulating less inside normal cells. Our findings show that ZnO NPs may be identified inside cancer cells after 1 h of exposure and can endure up to 3 h, providing them appropriate for tumor cell imaging. The findings showed that ZnO NPs might be employed as an alternate fluorophore for diagnostic imaging in the early identification of solid cancers. Therefore, here we studied in vitro applications of ZnO NPs and their beneficial use as a diagnostic tool for cancer cell lines rather than normal cells. Taken together, ZnO NPs can be used as good targeting NPs for the development of imaging agents for early diagnosis of cancers.

氧化锌纳米颗粒具有各种特性,使它们在许多医学应用中具有吸引力,如癌症诊断。它可以作为纳米探针在体外靶向不同类型的癌细胞,作为癌细胞识别系统。本研究旨在研究ZnO NPs在人体正常细胞系和癌细胞系中的通透性。本文描述了ZnO纳米粒子在活细胞环境下的体外实验,这将有助于纳米粒子作为癌症诊断和扫描技术的可视化。采用MCF7、AMJ13和RD癌细胞以及正常乳腺细胞系HBL进行体外成像实验。结果表明,ZnO NPs在肿瘤细胞内特异性结合,而在正常细胞内积累较少。我们的研究结果表明,ZnO NPs可以在暴露1小时后在癌细胞内被识别,并且可以持续长达3小时,为肿瘤细胞成像提供了合适的条件。结果表明,ZnO NPs可作为替代荧光团用于实体癌的早期诊断成像。因此,我们在这里研究了ZnO NPs在体外的应用,以及它们作为癌细胞系而不是正常细胞的诊断工具的有益用途。综上所述,ZnO NPs可以作为良好的靶向NPs,用于开发癌症早期诊断的显像剂。
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引用次数: 3
Color Matching of Universal Shade Resin-Based Composite with Natural Teeth and Its Stability before and after In-Office Bleaching. 通用色光树脂基复合材料与天然牙的配色及办公室漂白前后的稳定性
IF 3.1 Q2 Engineering Pub Date : 2022-10-26 eCollection Date: 2022-01-01 DOI: 10.1155/2022/8420890
AlHanouf AlHabdan, Ahoud AlShamrani, Randa AlHumaidan, AlJohrah AlFehaid, Sara Eisa

Objectives: Esthetics is an essential issue for the long-term success of composite resin restoration. Therefore, this study aimed to view the esthetics of universal shade composite resin restorations and to assess its color matching before and after bleaching.

Materials and methods: Overall, 40 freshly extracted premolars were mounted in an acrylic resin mold, and Class V cavities were then prepared and restored by OMNICHROMA composite (Tokuyama Dental, Tokyo, Japan) and polished with 2-step polishing system. Baseline color analysis was performed using VITA Easyshade V digital spectrophotometer, and another color analysis was carried out 24 hours after storage in distilled water. In-office bleaching was carried out, and color measurements were taken after bleaching and 2 weeks postbleaching. The data were statistically analyzed using SPSS 26.0 Windows version statistical software. Changes were considered statistically significant at P = 0.05.

Results: ΔE value of OMNICHROMA restoration before and after restoration was 6.474, 3.529 before and after bleaching, and 3.651 two-weeks postbleaching. In-office bleaching was effective in bleaching the OMNICHROMA specimens as the restoration showed positive ΔL values, which indicated that the specimens were lighter in color after bleaching; however, the bleaching effect was not maintained after 2 weeks.

Conclusion: OMNICHROMA universal shade composite resin restoration showed different color matching values with the adjacent enamel of class Vs. The material appeared lighter in shade postbleaching, and the color change was not maintained 2 weeks postbleaching.

目的:美学是复合树脂修复长期成功的关键问题。因此,本研究旨在观察通用阴影复合树脂修复体的美学,并评估其漂白前后的颜色匹配。材料和方法:将40颗新鲜提取的前磨牙安装在丙烯酸树脂模具中,然后用OMNICHROMA复合材料(Tokuyama Dental, Tokyo, Japan)制备和修复V级蛀牙,并使用两步抛光系统进行抛光。使用VITA Easyshade V数字分光光度计进行基线颜色分析,并在蒸馏水中保存24小时后进行另一次颜色分析。在办公室进行漂白,并在漂白后和漂白后2周进行颜色测量。采用SPSS 26.0 Windows版统计软件对数据进行统计学分析。P = 0.05认为变化具有统计学意义。结果:修复前后OMNICHROMA修复ΔE值为6.474,漂白前后为3.529,漂白后2周为3.651。室内漂白对OMNICHROMA标本有较好的漂白效果,修复后的ΔL *值为正,说明漂白后的标本颜色较浅;但2周后,漂白效果不再维持。结论:OMNICHROMA通用阴影复合树脂修复体与相邻的v类牙釉质的配色值不同,材料在阴影漂白后颜色变浅,漂白后2周颜色变化未维持。
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引用次数: 2
Comparative Study of Biotin and Hydroxyapatite on Biological Properties of Composite Coating. 生物素与羟基磷灰石对复合涂层生物学性能的比较研究。
IF 3.1 Q2 Engineering Pub Date : 2022-09-26 eCollection Date: 2022-01-01 DOI: 10.1155/2022/8802111
Qahtan A Hamad, Fatimah J Al-Hasani, Noor K Faheed

The ultimate goal of using biomaterials is to improve human health by restoring the function of natural living tissues and organs in the body. The present work aims to modify the composite coating layer properties by using two different types of bioactive reinforcing materials (biotin and hydroxyapatite) particles in different percentages (5% and 10%). Coatings were applied onto commercially pure Ti, SS 316 L, and SS 304 substrates by the dip-coating method. Characterization of samples includes microstructure observation by field emission scanning electron microscopy (FE-SEM), contact angle measurement (wettability), and MTT. The results show the addition of metallic particles (bioparticles) (hydroxyapatite particles, biotin) at 5 Vol. % improved the whole properties of composite materials. Using different particles' scale size aids to enhance the combinations in the alginate matrix producing a dual effect on composite film properties. In addition, the inclusion of metallic particles has to increase the wettability by reducing the contact angle. At the same time, MTT graphs revealed that after 3 days of exposure in MG-63 cells, 316 L SS alloys' surface following pack adhesion became more active.

使用生物材料的最终目标是通过恢复人体自然活组织和器官的功能来改善人类健康。本工作旨在通过使用两种不同类型的生物活性增强材料(生物素和羟基磷灰石)颗粒,以不同的百分比(5%和10%)来改变复合涂层的性能。通过浸涂法将涂层应用于商业纯Ti, ss316l和ss304基材上。样品的表征包括通过场发射扫描电镜(FE-SEM)观察微观结构,测量接触角(润湿性)和MTT。结果表明,5 Vol. %的羟基磷灰石颗粒、生物素等金属颗粒(生物颗粒)的加入改善了复合材料的整体性能。使用不同粒径的颗粒有助于增强藻酸盐基质中的结合,对复合膜性能产生双重影响。此外,金属颗粒的加入必须通过减小接触角来增加润湿性。与此同时,MTT图显示,MG-63细胞暴露3天后,316 L SS合金表面在pack粘附后变得更加活跃。
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引用次数: 4
Optimization, Characterization, and Anticancer Potential of Silver Nanoparticles Biosynthesized Using Olea europaea. 油橄榄生物合成银纳米颗粒的优化、表征及抗癌潜力。
IF 3.1 Q2 Engineering Pub Date : 2022-09-26 eCollection Date: 2022-01-01 DOI: 10.1155/2022/6859637
Afnan I Felimban, Njud S Alharbi, Nehad S Alsubhi

Green synthesis has attracted significant attention as an eco-friendly, low-cost, energy-efficient, and non-toxic method for preparing silver nanoparticles (AgNPs) for cancer therapy. This study optimized the green synthesis of AgNPs using Olea europaea extracts and evaluated their anticancer potential. The biosynthesized AgNPs were characterized using various methods, showing stable AgNPs with a desirable morphology and high yield, improving the properties of AgNPs for various medicinal applications. The biosynthesized AgNPs were predominantly spherical, with small sizes ranging from 13 to 21 nm and highly stable at -23 and -24 mV. The findings of this study suggest that green-synthesized AgNPs using Olea europaea and sunlight possess significant anticancer activity against cancer cells in vitro. Further investigation of green synthesis would help to form high-quality AgNPs that have promising potential in treating disease and fighting undesirable pathogens.

绿色合成作为一种环保、低成本、高能效和无毒的制备纳米银纳米粒子(AgNPs)的方法受到了广泛的关注。本研究优化了油橄榄提取物绿色合成AgNPs的工艺,并对其抗癌潜力进行了评价。采用多种方法对生物合成的AgNPs进行了表征,结果表明AgNPs具有良好的形态和高产率,从而提高了AgNPs的各种药用性能。生物合成的AgNPs主要呈球形,尺寸较小,范围在13 ~ 21 nm之间,在-23和-24 mV下高度稳定。本研究结果表明,利用油橄榄和阳光绿色合成的AgNPs具有明显的体外抗癌活性。绿色合成的进一步研究将有助于形成高质量的AgNPs,这些AgNPs在治疗疾病和对抗不良病原体方面具有广阔的潜力。
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引用次数: 2
Histological Evaluation of the Effect of Local Application of Punica granatum Seed Oil on Bone Healing. 局部应用石榴籽油对骨愈合影响的组织学评价。
IF 3.1 Q2 Engineering Pub Date : 2022-09-24 eCollection Date: 2022-01-01 DOI: 10.1155/2022/4266589
Ibrahim Fouad Mohamed, Ban A Ghani, Abdalbseet A Fatalla

Background: Bone healing is a complex and dynamic process that represents a well-orchestrated series of biological events of cellular recruitment, proliferation, and differentiation. The use of medicinal plants in bone healing has attracted increasing interest because of their lower side effects. Punica granatum seed oil (PSO) contains high levels of phenolic compounds, promotes osteoblast function, and plays an important role in bone remodeling. A gelatin sponge (Spongostan) is a hemostatic agent that is extensively applied as scaffolds in engineering and as drug carriers in the medical field. This study aimed to evaluate the effectiveness of PSO for bone healing enhancement. Twenty adult male New Zealand rabbits, weighing an average of 1.5-2 kg, were used in this study. Three intrabony holes were created in the tibiae of each animal, which were filled with a gelatin sponge (GS group) and combined gelatin sponge and PSO (GS/PSO group). Holes without material application were designated as the control group (C group). The animals were sacrificed at the healing duration (2-4 weeks) to prepare bone specimens for histological and histomorphometric analyses.

Results: Histological findings indicated that the bone defects in the GS/PSO group showed more bone formation, mineralization, and maturation compared with the C and GS groups. Multiple group differences for bone cells showed a highly significant difference among all groups in the 2- and 4-week healing periods except for the C/GS and GS/GS/PSO groups at 4-weeks duration. Furthermore, highly significant results were obtained between both durations regarding the trabecular area, trabecular number, and bone marrow area.

Conclusion: The study revealed that the combined application of GS and PSO was more effective in enhancing bone regeneration and accelerating bone healing compared with the other groups.

背景:骨愈合是一个复杂而动态的过程,它代表了一系列精心策划的细胞募集、增殖和分化的生物学事件。药用植物在骨愈合中的应用因其副作用小而引起了人们越来越多的兴趣。石榴籽油(PSO)含有高水平的酚类化合物,促进成骨细胞功能,并在骨重塑中发挥重要作用。明胶海绵(Spongostan)是一种止血剂,在工程上广泛用作支架,在医学上广泛用作药物载体。本研究旨在评价PSO对骨愈合的促进作用。本研究选用平均体重1.5-2 kg的成年雄性新西兰兔20只。每只动物胫骨造3个骨内孔,分别用明胶海绵(GS组)和明胶海绵+ PSO组合(GS/PSO组)填充。取未施加材料的孔作为对照组(C组)。在愈合期间(2-4周)处死动物,制备骨标本进行组织学和组织形态学分析。结果:组织学结果显示,与C和GS组相比,GS/PSO组骨缺损的骨形成、矿化和成熟程度更高。骨细胞多组差异除C/GS组和GS/GS/PSO组4周外,其余各组在2周和4周愈合时差异极显著。此外,在小梁面积、小梁数量和骨髓面积方面,两种持续时间之间获得了高度显著的结果。结论:本研究显示,与其他组相比,GS与PSO联合应用能更有效地促进骨再生和骨愈合。
{"title":"Histological Evaluation of the Effect of Local Application of <i>Punica granatum</i> Seed Oil on Bone Healing.","authors":"Ibrahim Fouad Mohamed,&nbsp;Ban A Ghani,&nbsp;Abdalbseet A Fatalla","doi":"10.1155/2022/4266589","DOIUrl":"https://doi.org/10.1155/2022/4266589","url":null,"abstract":"<p><strong>Background: </strong>Bone healing is a complex and dynamic process that represents a well-orchestrated series of biological events of cellular recruitment, proliferation, and differentiation. The use of medicinal plants in bone healing has attracted increasing interest because of their lower side effects. <i>Punica granatum</i> seed oil (PSO) contains high levels of phenolic compounds, promotes osteoblast function, and plays an important role in bone remodeling. A gelatin sponge (Spongostan) is a hemostatic agent that is extensively applied as scaffolds in engineering and as drug carriers in the medical field. This study aimed to evaluate the effectiveness of PSO for bone healing enhancement. Twenty adult male New Zealand rabbits, weighing an average of 1.5-2 kg, were used in this study. Three intrabony holes were created in the tibiae of each animal, which were filled with a gelatin sponge (GS group) and combined gelatin sponge and PSO (GS/PSO group). Holes without material application were designated as the control group (C group). The animals were sacrificed at the healing duration (2-4 weeks) to prepare bone specimens for histological and histomorphometric analyses.</p><p><strong>Results: </strong>Histological findings indicated that the bone defects in the GS/PSO group showed more bone formation, mineralization, and maturation compared with the C and GS groups. Multiple group differences for bone cells showed a highly significant difference among all groups in the 2- and 4-week healing periods except for the C/GS and GS/GS/PSO groups at 4-weeks duration. Furthermore, highly significant results were obtained between both durations regarding the trabecular area, trabecular number, and bone marrow area.</p><p><strong>Conclusion: </strong>The study revealed that the combined application of GS and PSO was more effective in enhancing bone regeneration and accelerating bone healing compared with the other groups.</p>","PeriodicalId":13704,"journal":{"name":"International Journal of Biomaterials","volume":null,"pages":null},"PeriodicalIF":3.1,"publicationDate":"2022-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9526640/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33486549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Synthesis of Carbon-Encapsulated Magnetic Iron Oxide Nanocomposites for Bioapplication. 生物应用碳包封磁性氧化铁纳米复合材料的合成。
IF 3.1 Q2 Engineering Pub Date : 2022-09-20 eCollection Date: 2022-01-01 DOI: 10.1155/2022/3302082
Wubshet Mekonnen Girma

Carbon-encapsulated Fe3O4 nanoparticles (NPs) were successfully synthesized from a single precursor using one-step solvothermal methods. X-ray diffraction and transmission electron microscopy were used to characterize the as-prepared NPs, and UV-visible absorbance spectroscopy was used to check their optical properties. The morphological results revealed that Fe3O4@C, quasi-spherical Fe3O4 particles encapsulated by carbon. In addition, the carbon-encapsulated Fe3O4 NPs were conjugated with folic acid (FA) to be used as biomarkers in the diagnosis and treatment of tumour cells. Fourier transform infrared spectroscopy and UV-visible spectroscopic techniques were used to confirm the conjugation process.

采用一步溶剂热法制备了碳包覆的Fe3O4纳米颗粒。利用x射线衍射和透射电子显微镜对制备的NPs进行表征,并利用紫外可见吸收光谱对其光学性质进行表征。形貌结果表明:Fe3O4@C,准球形Fe3O4颗粒被碳包裹。此外,碳包封的Fe3O4 NPs与叶酸(FA)偶联,可作为肿瘤细胞诊断和治疗的生物标志物。傅里叶变换红外光谱和紫外可见光谱技术证实了共轭过程。
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引用次数: 2
Green Biosynthesis of Silver Nanoparticles from Moringa oleifera Leaves and Its Antimicrobial and Cytotoxicity Activities. 辣木叶中纳米银的绿色合成及其抑菌和细胞毒活性
IF 3.1 Q2 Engineering Pub Date : 2022-09-19 eCollection Date: 2022-01-01 DOI: 10.1155/2022/4136641
Gufran Mahmood Mohammed, Sumaiya Naeema Hawar

The plant occupied the largest area in the biosynthesis of silver nanoparticles, especially the medicinal plants, and it has shown great potential in biotechnology applications. In this study, green synthesis of silver nanoparticles from Moringa oleifera leaves extract and its antifungal and antitumor activities were investigated. The formation of silver nanoparticles was observed after 1 hour of preparation color changing. The ultraviolet and visible spectrum, Fourier transform infrared spectroscopy, X-ray diffraction, scanning electron microscopy, and transmission electron microscopy techniques were used to characterize synthesis particles. Ultraviolet and visible spectroscopy showed a silver surface plasmon resonance band at 434 nm. Fourier transform infrared analysis shows the possible interactions between silver and bioactive molecules in Moringa oleifera leaves extracts, which may be responsible for the synthesis and stabilization of silver nanoparticles. X-ray diffraction showed that the particles were a semicubic crystal structure and with a size of 38.495 nm. Scanning electron microscopy imaging shows that the atoms are spherical in shape and the average size is 17 nm. The transmission electron microscopy image demonstrated that AgNPs were spherical and semispherical particles with an average of (50-60) nm. The nanoparticles also showed potent antimicrobial activity against pathogenic bacteria and fungi using the well diffusion method. Candida glabrata found that the concentration of 1000 μg/mL exhibited the highest inhibition. As for bacteria, the concentration of 1000 μg/mL appeared to be the inhibition against Staphylococcus aureus. Moringa oleifera AgNPs inhibited human melanoma cells A375 line significant concentration-dependent cytotoxic effects. The powerful bioactivity of the green synthesized silver nanoparticles from medical plants recommends their biomedical use as antimicrobial as well as cytotoxic agents.

纳米银的生物合成以植物为主,尤其是药用植物,在生物技术应用中显示出巨大的潜力。本研究以辣木叶提取物为原料,绿色合成纳米银,并对其抗真菌和抗肿瘤活性进行了研究。制备1小时后观察银纳米颗粒的形成。利用紫外和可见光谱、傅里叶变换红外光谱、x射线衍射、扫描电镜和透射电镜等技术对合成颗粒进行了表征。紫外和可见光谱在434 nm处显示出银表面等离子体共振带。傅里叶变换红外分析表明,辣木叶提取物中的银与生物活性分子之间可能存在相互作用,这种相互作用可能是银纳米颗粒合成和稳定的原因。x射线衍射结果表明,该颗粒为半立方晶体结构,粒径为38.495 nm。扫描电镜成像显示,原子呈球形,平均尺寸为17 nm。透射电镜图像显示AgNPs为球形和半球形颗粒,平均粒径为(50 ~ 60)nm。利用孔扩散法对病原菌和真菌也表现出较强的抑菌活性。结果表明,浓度为1000 μg/mL时对光秃念珠菌的抑制作用最强。对细菌,1000 μg/mL浓度对金黄色葡萄球菌有抑制作用。辣木AgNPs抑制人黑色素瘤细胞A375系显著浓度依赖性细胞毒作用。从药用植物中合成的绿色银纳米颗粒具有强大的生物活性,推荐它们作为抗菌剂和细胞毒性药物在生物医学上使用。
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引用次数: 10
Prediction of Length of Hospital Stay of COVID-19 Patients Using Gradient Boosting Decision Tree. 基于梯度增强决策树的COVID-19患者住院时间预测
IF 3.1 Q2 Engineering Pub Date : 2022-09-16 eCollection Date: 2022-01-01 DOI: 10.1155/2022/6474883
GholamReza Askari, Mohammad Hossein Rouhani, Mohammad Sattari

The aim of this paper is to predict the patient hospitalization time with coronavirus disease 2019 (COVID-19). It uses various data mining techniques, such as random forest. Many rules were derived by applying these techniques to the dataset. The extracted rules mainly were related to people over 55 years old. The rule with the most support states that if the person is between 70 and 80 years old, has cardiovascular disease, and the gender is female; then, the person will be hospitalized for at least five days. The gradient boosting random forest technique has performed better than other techniques. As a limitation of the study, it can be pointed out that a few features were unavailable and had not been recorded. Patients with diabetes, chronic respiratory problems, and cardiovascular diseases have a relatively long hospitalization. So, the hospital manager should consider a suitable priority for these patients. Older people were also more likely to take part in the selection rules.

本文的目的是预测2019冠状病毒病(COVID-19)患者住院时间。它使用各种数据挖掘技术,如随机森林。通过将这些技术应用于数据集派生出许多规则。提取的规则主要与55岁以上的人有关。支持度最高的规则规定,如果该人年龄在70至80岁之间,患有心血管疾病,性别为女性;然后,患者将住院至少5天。梯度增强随机森林技术已经取得了较好的效果。作为研究的局限性,可以指出的是,一些特征是不可用的,没有被记录。患有糖尿病、慢性呼吸系统疾病和心血管疾病的患者住院时间相对较长。因此,医院管理者应该考虑为这些患者提供合适的优先级。年龄较大的人也更有可能参与选择规则。
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引用次数: 0
Utilization of Biang Fish Flour (Ilisha elongata) as an Enrichment Material for Sago Noodles Nutrient Value. Biang鱼粉作为西米面营养价值富集材料的研究
IF 3.1 Q2 Engineering Pub Date : 2022-09-10 eCollection Date: 2022-01-01 DOI: 10.1155/2022/8746296
Suparmi Suparmi, Sumarto Sumarto, Umi Afriana, Taufik Hidayat

This study aims to determine the appropriate concentration of lead fish meal for enriching the nutritional value of sago noodles favored by consumers. The method used is an experimental design using Completely Randomized (CRD) with 4 concentration levels of lead fish meal, namely, 4% without a lead fish meal (M0), 6% (M1), 8% (M2), and 10% (M3). The analysis of sago noodles was performed and proximate by the AOAC method; amino acids by HPLC; fatty acids by GC; and minerals by HPLC. The results of the showed that the study getting the best treatment was a concentration of 8% (M2) with the characteristics of whole sago noodles' appearance: attractive, grayish-white color; a distinctive aroma of sago noodles with a hint of fish; a specific taste typical of sago noodles and fish prickly taste; delicious; slightly chewy texture. Sensory evaluation with a taste value of 8.9, an aroma of 8.6, a visual value of 8.9, and a texture value of 8.8. Its nutritional content is 5.58% protein content, air 22.35%, ash 1.69%, fat 1.41%, and carbohydrates 68.29%. The proximate values are protein 5.58%, water content 22.35%, ash 1.69%, fat content 1.41%, and carbohydrates (different) 68.29%. The mineral content is Ca.P.I, Mg, Zn, and Fe. Amino acids consist of 8 types of essential amino acids, namely, histidine, arginine, threonine, valine, alanine, methionine, isoleucine, leucine, phenylalanine, and 7 types of nonessential amino acids, namely, aspartic acid, glutamic acid, serine, glycine, tyrosine. Its fatty acid profile has 13 components of unsaturated fatty acids and 17 components of saturated fatty acids.

本研究旨在确定适当的铅鱼粉浓度,以提高消费者喜爱的西米面的营养价值。采用完全随机(CRD)试验设计,添加4种浓度水平的铅鱼粉,即4%不添加铅鱼粉(M0)、6% (M1)、8% (M2)和10% (M3)。采用AOAC法对西米面进行分析和近似;HPLC法测定氨基酸;脂肪酸气相色谱法;和矿物质。结果表明,以8% (M2)的浓度处理效果最佳,使整个西米面外观呈吸引人的灰白色;西米面条的独特香气带着一丝鱼的味道;有西米面特有的味道和鱼刺的味道;美味的;稍微有嚼劲。感官评价:口感值8.9,香气值8.6,视觉值8.9,质地值8.8。其营养成分为蛋白质5.58%,空气22.35%,灰分1.69%,脂肪1.41%,碳水化合物68.29%。近似值为蛋白质5.58%,水分22.35%,灰分1.69%,脂肪1.41%,碳水化合物(不同)68.29%。矿物含量为Ca.P。I, Mg, Zn和Fe。氨基酸包括8种必需氨基酸,即组氨酸、精氨酸、苏氨酸、缬氨酸、丙氨酸、蛋氨酸、异亮氨酸、亮氨酸、苯丙氨酸;7种非必需氨基酸,即天冬氨酸、谷氨酸、丝氨酸、甘氨酸、酪氨酸。其脂肪酸谱有13个不饱和脂肪酸组分和17个饱和脂肪酸组分。
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引用次数: 1
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