Pub Date : 2024-04-01DOI: 10.47552/ijam.v15i1.4173
Soubhaghyalaxmi B, Gundakalle M B, Vinay P S
Introduction: With the presence of extensive number of various microbes in the living environment, there is need to explore few sustainable and safe practices to control the ill effects of the microbes. In Indian tradition the Dhoopana (fumigation process) is well established since time immemorial and it is practiced regularly for different purposes. Many of the formulations quoted in the classics are already in practice. Acharya Sushruta, in Kalpasthana quotes the use of Vayu Nirvishikarana Yoga for Dhoopana-artha in the chikitsa of Dushita Vayu. Therefore, it is necessary to adopt safer methods like Dhoopana with the herbal formulations for the disease control. Methods: Vayu Nirvishikarana yoga comprising of 11 drugs, predominantly constitutes of volatile oils, alkaloids and tannins from the respective drugs. There are proven studies over the antimicrobial property, anti-oxidant properties of various drugs of this formulation. Results: The study was conducted to showcase the efficacy of the Dhoopana yoga in an indoor environment in terms of limiting the microbial load. The results of this work showed considerable results with sufficient scope for further studies. Conclusion: Krimighna and Vishaghna gunas of these drugs used in this formulation can be justified as explained in the classics. After evaluating the existing data about Dhoopana process and executing the study, its effectiveness becomes self-evident, but scientific approach and evidence are required to mainstream them and to establish the formulations as primary disinfection measures.
{"title":"Evaluation of anti-microbial effect of Sushrutokta Vayu-Nirvishikarana yoga","authors":"Soubhaghyalaxmi B, Gundakalle M B, Vinay P S","doi":"10.47552/ijam.v15i1.4173","DOIUrl":"https://doi.org/10.47552/ijam.v15i1.4173","url":null,"abstract":"Introduction: With the presence of extensive number of various microbes in the living environment, there is need to explore few sustainable and safe practices to control the ill effects of the microbes. In Indian tradition the Dhoopana (fumigation process) is well established since time immemorial and it is practiced regularly for different purposes. Many of the formulations quoted in the classics are already in practice. Acharya Sushruta, in Kalpasthana quotes the use of Vayu Nirvishikarana Yoga for Dhoopana-artha in the chikitsa of Dushita Vayu. Therefore, it is necessary to adopt safer methods like Dhoopana with the herbal formulations for the disease control. Methods: Vayu Nirvishikarana yoga comprising of 11 drugs, predominantly constitutes of volatile oils, alkaloids and tannins from the respective drugs. There are proven studies over the antimicrobial property, anti-oxidant properties of various drugs of this formulation. Results: The study was conducted to showcase the efficacy of the Dhoopana yoga in an indoor environment in terms of limiting the microbial load. The results of this work showed considerable results with sufficient scope for further studies. Conclusion: Krimighna and Vishaghna gunas of these drugs used in this formulation can be justified as explained in the classics. After evaluating the existing data about Dhoopana process and executing the study, its effectiveness becomes self-evident, but scientific approach and evidence are required to mainstream them and to establish the formulations as primary disinfection measures. ","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140772524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Cutaneous adverse drug reactions are among the most common types of drug hypersensitivity reactions. Although considered natural and safe, Ayurveda medicines can cause adverse reactions. This article highlights the cases of cutaneous adverse drug reactions possibly due to external application of Nagaradi lepa. Materials and Methods: This is an observational, retrospective and record based study conducted by analyzing the spontaneous reported ADR forms, caused by the external application of Nagaradi lepa, collected over a period of 12 months (April 2022 to March 2023) at Peripheral Pharmacovigilance Centre, VPSV Ayurveda College Kottakkal, Kerala. Results: During the period of one year, 3 cutaneous ADRs were reported due to external application of Nagaradi lepa. All the 3 cases fall under the category of Probable according to Naranjo’s ADR Probability scale. 2 cases were mild and 1 case was moderate in severity. All the 3 cases were recovered from ADR. Conclusion: Though under reporting, we may have to consider the possibility of Ayurvedic drugs to cause adverse drug reactions. Pharmacovigilance is an ongoing and continuous process. Reporting of ADR to Pharmacovigilance centers help to generate information on ADR related Ayurvedic formulations and also to prevent its recurrence.
{"title":"Cutaneous Adverse Drug Reactions on application of Nagaradi Lepa - A Retrospective analysis","authors":"Haseena Kurikkal, Vidhya Unnikrishnan, Manojkumar Narayanan","doi":"10.47552/ijam.v15i1.4166","DOIUrl":"https://doi.org/10.47552/ijam.v15i1.4166","url":null,"abstract":"Introduction: Cutaneous adverse drug reactions are among the most common types of drug hypersensitivity reactions. Although considered natural and safe, Ayurveda medicines can cause adverse reactions. This article highlights the cases of cutaneous adverse drug reactions possibly due to external application of Nagaradi lepa. Materials and Methods: This is an observational, retrospective and record based study conducted by analyzing the spontaneous reported ADR forms, caused by the external application of Nagaradi lepa, collected over a period of 12 months (April 2022 to March 2023) at Peripheral Pharmacovigilance Centre, VPSV Ayurveda College Kottakkal, Kerala. Results: During the period of one year, 3 cutaneous ADRs were reported due to external application of Nagaradi lepa. All the 3 cases fall under the category of Probable according to Naranjo’s ADR Probability scale. 2 cases were mild and 1 case was moderate in severity. All the 3 cases were recovered from ADR. Conclusion: Though under reporting, we may have to consider the possibility of Ayurvedic drugs to cause adverse drug reactions. Pharmacovigilance is an ongoing and continuous process. Reporting of ADR to Pharmacovigilance centers help to generate information on ADR related Ayurvedic formulations and also to prevent its recurrence. ","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140789200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-07DOI: 10.47552/ijam.v14i4.3965
Monali Mohite, Madhulika Tiwari, Kalmegh M S, Rani Mudgal, Rupali R Bawa
Bhagandara one of the eight grave disorders, pertaining the perianal region is arduous to treat, has been described in detail by Acharaya Sushruta. The Ayurvedic description of Bhagandara can be identified as associated with an anal fistula. An anal fistula is defined as an internal opening in the altered skin or mucosa of the anal canal or rectum and an exterior opening in the perianal skin region. Among the various modalities available for the treatment of bhagandara, ksharasutra is described as gold standards for treatment and cure. The ksharasutra possess antimicrobial properties and can be established as first line of treatment for bhagandar(fistula-in-ano). The modern approach for fistula-in-ano is surgical procedure. Antibiotics are commonly used along with surgery for the treatment of fistula-in-ano. The aim of this study was to comparatively evaluate the antimicrobial properties amongst Snuhi-apamarga kshar sutra and Udumbara ksheer sutra. A total no. of 60 participants were enrolled as per the criteria for the study and pus samples were collected as per the standard operating procedure. Samples of Snuhi-apamarga kshar sutra and Udumbar ksheer sutra were already given in laboratory for testing the sensitivity. Reports were collected and analyzed on different parameters and conclusion was drawn accordingly. It was concluded that gram positive monomicrobial infections were more common especially involving staphylococci. Also, in the culture and sensitivity test Snuhi- apamarga ksharsutra was found to be more effective in comparison to Udumbara ksheer sutra as the microbes were highly sensitive to the Snuhi Apamarga kshar sutra. This can be contributed to the multiple contents in Snuhi Apamarga kshar sutra.
{"title":"A Comparative Evaluation of Antimicrobial Effect of Snuhi-Apamarg-Ksharsutra and Udumbara-Ksheer Sutra in the Management of Bhagandara (Fistula-In-Ano)","authors":"Monali Mohite, Madhulika Tiwari, Kalmegh M S, Rani Mudgal, Rupali R Bawa","doi":"10.47552/ijam.v14i4.3965","DOIUrl":"https://doi.org/10.47552/ijam.v14i4.3965","url":null,"abstract":"Bhagandara one of the eight grave disorders, pertaining the perianal region is arduous to treat, has been described in detail by Acharaya Sushruta. The Ayurvedic description of Bhagandara can be identified as associated with an anal fistula. An anal fistula is defined as an internal opening in the altered skin or mucosa of the anal canal or rectum and an exterior opening in the perianal skin region. Among the various modalities available for the treatment of bhagandara, ksharasutra is described as gold standards for treatment and cure. The ksharasutra possess antimicrobial properties and can be established as first line of treatment for bhagandar(fistula-in-ano). The modern approach for fistula-in-ano is surgical procedure. Antibiotics are commonly used along with surgery for the treatment of fistula-in-ano. The aim of this study was to comparatively evaluate the antimicrobial properties amongst Snuhi-apamarga kshar sutra and Udumbara ksheer sutra. A total no. of 60 participants were enrolled as per the criteria for the study and pus samples were collected as per the standard operating procedure. Samples of Snuhi-apamarga kshar sutra and Udumbar ksheer sutra were already given in laboratory for testing the sensitivity. Reports were collected and analyzed on different parameters and conclusion was drawn accordingly. It was concluded that gram positive monomicrobial infections were more common especially involving staphylococci. Also, in the culture and sensitivity test Snuhi- apamarga ksharsutra was found to be more effective in comparison to Udumbara ksheer sutra as the microbes were highly sensitive to the Snuhi Apamarga kshar sutra. This can be contributed to the multiple contents in Snuhi Apamarga kshar sutra.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2024-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139629237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-07DOI: 10.47552/ijam.v14i4.3873
Roshani Yawale, Yusuf Sheikh M, R. Gurmule, Gopal Sharma
In Ayurveda the word “Pramana” refers to measurement. Ayurveda classic have explained the normal measurements of Anga Pratyanga in terms of Ayama (length), Vistaar (breadth), Utsedha (height) and Parinaha (circumference) with the help of Swa-Anguli Pramana (measurement by own finger). In the ancient time length, breadth, and height of body’s parts measured by using the technique of Anguli Pramana in which measurements of parts of body have given in terms of Swa-Anguli. It can be the perfect parameter irrespective of age, sex, race and place etc. Principles of Ayurveda have given the individualistic approach rather than the generalized by providing the concept of Swa-Anguli Pramana. Acharyas said that before we start the treatment one should do the Ayu Pariksha (longativity of life) of that patient which is depends upon proper measurement of parts and sub parts of body along with Sara of body. Present study was taken to validate the Dalnhokta Anguli Pramana of Purusha Ura Vistaar (Male chest breadth) which was given as 24 Angula. The data of Purusha Ura Vistaar of 60 healthy volunteers was collected and statistically analyzed. As the very less work has been done the current study was conducted. Keywords: Anthropometry, Swa-Anguli Pramana (measurements by own finger), Measurements, Diameter, Ayam (length),
{"title":"Scientific Study of Dalhanokta Anguli Pramana (Measurement) with reference to Purusha Ura Vistaar (Male Chest Breadth)","authors":"Roshani Yawale, Yusuf Sheikh M, R. Gurmule, Gopal Sharma","doi":"10.47552/ijam.v14i4.3873","DOIUrl":"https://doi.org/10.47552/ijam.v14i4.3873","url":null,"abstract":"In Ayurveda the word “Pramana” refers to measurement. Ayurveda classic have explained the normal measurements of Anga Pratyanga in terms of Ayama (length), Vistaar (breadth), Utsedha (height) and Parinaha (circumference) with the help of Swa-Anguli Pramana (measurement by own finger). In the ancient time length, breadth, and height of body’s parts measured by using the technique of Anguli Pramana in which measurements of parts of body have given in terms of Swa-Anguli. It can be the perfect parameter irrespective of age, sex, race and place etc. Principles of Ayurveda have given the individualistic approach rather than the generalized by providing the concept of Swa-Anguli Pramana. Acharyas said that before we start the treatment one should do the Ayu Pariksha (longativity of life) of that patient which is depends upon proper measurement of parts and sub parts of body along with Sara of body. Present study was taken to validate the Dalnhokta Anguli Pramana of Purusha Ura Vistaar (Male chest breadth) which was given as 24 Angula. The data of Purusha Ura Vistaar of 60 healthy volunteers was collected and statistically analyzed. As the very less work has been done the current study was conducted. \u0000Keywords: Anthropometry, Swa-Anguli Pramana (measurements by own finger), Measurements, Diameter, Ayam (length),","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2024-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139629459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-07DOI: 10.47552/ijam.v14i4.3514
Chaitali Chaudhari, Renu Rathi, P. Yewale
Background: Tobacco use is the second major cause of death and the fourth most common health risk factor affecting the world. Medical professionals have a critical role in the process of smoking cessation both as adviser sand behavioral models for the citizens. In India, tobacco use is quite rampant with every fourth adult person in the country reported to be using it.The perception of the harmful effects of tobacco is also considerably low as only 35.1% of smokeless tobacco users and49.3%of tobacco users thought it to be harmful in are centpan- India survey. Materials & Methods: It is across-sectional study among100 health care workers of DMIMS, Wardha which was conducted using a WHO questionnaire, Power Point presentation was shown and was completed within an interval of 15 days. Observation & Result: It is observed from the study that there was total of 83 health care workers who were consuming tobacco regularly. 69.2% tried to quit this addiction in their past life and 49 health care workers stated a history of withdrawal symptoms. Discussion: After looking at the vision of the health care workers(health care workers),the proper guidance has been provided in order to quit. The habit by means of Ayurved modalities. Conclusion: The interpretation derived from the study is that among100 participants75% were 3rd and 4th class health care workerss (wardboy–attendant).They were influenced by their surroundings to have tobacco-related products which subsequently turned into a habit and then into an addiction that was now difficult to curb.
背景：吸烟是导致死亡的第二大原因，也是影响世界的第四大常见健康风险因素。医务人员在戒烟过程中扮演着至关重要的角色，他们既是戒烟顾问，又是公民的行为楷模。在印度，烟草的使用相当猖獗，据报告该国每四个成年人中就有一人在使用烟草。对烟草有害影响的认识也相当低，在印度人口中心的调查中，只有 35.1%的无烟烟草使用者和 49.3%的烟草使用者认为烟草有害。材料与方法：这是一项横断面研究，调查对象为沃达（Wardha）DMIMS 的 100 名医护人员，采用世界卫生组织的调查问卷，并通过 Power Point 演示，在 15 天内完成。观察与结果：研究发现，共有 83 名医护人员经常吸烟。69.2%的医护人员在过去曾尝试戒烟，49%的医护人员曾出现戒断症状。讨论在了解了医护人员的愿景后，我们为他们提供了正确的戒烟指导。通过阿育吠陀疗法戒除毒瘾。结论：在 100 名参与者中，75% 是三等和四等医护人员（护工）。他们受到周围环境的影响，开始接触与烟草有关的产品，并逐渐养成了习惯，进而形成了现在难以戒除的烟瘾。
{"title":"Prevalence and health impact of tobacco addiction among Health workers of DMIMS along with de-addiction awareness using Ayurveda modalities – A cross-sectional study","authors":"Chaitali Chaudhari, Renu Rathi, P. Yewale","doi":"10.47552/ijam.v14i4.3514","DOIUrl":"https://doi.org/10.47552/ijam.v14i4.3514","url":null,"abstract":"Background: Tobacco use is the second major cause of death and the fourth most common health risk factor affecting the world. Medical professionals have a critical role in the process of smoking cessation both as adviser sand behavioral models for the citizens. In India, tobacco use is quite rampant with every fourth adult person in the country reported to be using it.The perception of the harmful effects of tobacco is also considerably low as only 35.1% of smokeless tobacco users and49.3%of tobacco users thought it to be harmful in are centpan- India survey. Materials & Methods: It is across-sectional study among100 health care workers of DMIMS, Wardha which was conducted using a WHO questionnaire, Power Point presentation was shown and was completed within an interval of 15 days. Observation & Result: It is observed from the study that there was total of 83 health care workers who were consuming tobacco regularly. 69.2% tried to quit this addiction in their past life and 49 health care workers stated a history of withdrawal symptoms. Discussion: After looking at the vision of the health care workers(health care workers),the proper guidance has been provided in order to quit. The habit by means of Ayurved modalities. Conclusion: The interpretation derived from the study is that among100 participants75% were 3rd and 4th class health care workerss (wardboy–attendant).They were influenced by their surroundings to have tobacco-related products which subsequently turned into a habit and then into an addiction that was now difficult to curb. ","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2024-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139535885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-07DOI: 10.47552/ijam.v14i4.3781
Himakshi Tanwar, Jayashree Patil
Ayurveda is an ancient science, which deals with the various treatments, its prevention and various principles for management of diseases are described in Ayurveda. Ayurveda has mentioned Ashtanga Ayurveda in which Balaroga under which Streeroga and Prasruti Tantra was mentioned. Shwetapradara is one of the important disorder found in gynaecological practice. It can be correlated with Leucorrhoea in modern science. Shwetapradara is a condition which is characterized by Vaginal discharge (Yoni Srava) without any pain, discomfort and burning sensation, Vaginal Itching (Yoni kandu) etc. It is mentioned as one of the symptom presents in many gynaecological disorders. Ayurveda has mentioned various treatments for the management of Shwetapradara in which Shamana Chikitsa is important line of treatment. In this case study, Shamana Chikitsa as a Pippalyadi varti used for the management of Shwetapradara w.s.r. to Leucorrhoea.
{"title":"Case report of Shwetapradara in Ayurveda w.s.r. to Leucorrhoea","authors":"Himakshi Tanwar, Jayashree Patil","doi":"10.47552/ijam.v14i4.3781","DOIUrl":"https://doi.org/10.47552/ijam.v14i4.3781","url":null,"abstract":"Ayurveda is an ancient science, which deals with the various treatments, its prevention and various principles for management of diseases are described in Ayurveda. Ayurveda has mentioned Ashtanga Ayurveda in which Balaroga under which Streeroga and Prasruti Tantra was mentioned. Shwetapradara is one of the important disorder found in gynaecological practice. It can be correlated with Leucorrhoea in modern science. Shwetapradara is a condition which is characterized by Vaginal discharge (Yoni Srava) without any pain, discomfort and burning sensation, Vaginal Itching (Yoni kandu) etc. It is mentioned as one of the symptom presents in many gynaecological disorders. Ayurveda has mentioned various treatments for the management of Shwetapradara in which Shamana Chikitsa is important line of treatment. In this case study, Shamana Chikitsa as a Pippalyadi varti used for the management of Shwetapradara w.s.r. to Leucorrhoea.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2024-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139536012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-07DOI: 10.47552/ijam.v14i4.3967
Debaleena Acharjee, Deepak Thorat
Introduction: Shitapitta is a skin ailment that was first reported in Madhava Nidan which can be correlated to urticaria. It is a disorder characterized by symptoms comparable to Insect and scorpion bite, such as wheals resembling those from a wasp sting, itching, pain, fever, and burning feeling. Champakadi Agad is one of the Ayurveda formulations listed in Chapter 37/71-72 of Ashtanga Hridaya Uttarasthana by Acharya Vagbhata. Agadas are used to cure a variety of toxic conditions. Aims: To study the effect of Champakadi agad for local as well as internal use in case of Shitapitta. Case Report: This article is a case study about a 24 yrs old female patient who came to the OPD of Panchakarma Dept of Dr. D. Y. Patil College and hospital, Pimpri, Pune complaining of itchy skin, raised reddish bumps over the skin along with burning and pricing pain over her both palms and cheeks. She was treated with Champakadi Agad’s Local application for 30 days. Results after 30 days was found satisfactory. With no negative side effects, the therapy methods significantly reduced the disease's indications and symptoms. Discussion:This is a case study based on the management of Shitapitta (Urticaria). This study established the role of Champakadi Agad in the treatment of Shitapitta (Urticaria). Conclusion:The treatment of Shitapitta by Ayurvedic measures has been thoroughly examined and discussed here. Her progression is also shown here, step by step. This case study will encourage further research and aid in the development of an ayurvedic treatment protocol for Shitapitta (Urticaria).
{"title":"Effect of Champakadi Agad in the Management of Shitapitta w.s.r. to Urticaria - A case study","authors":"Debaleena Acharjee, Deepak Thorat","doi":"10.47552/ijam.v14i4.3967","DOIUrl":"https://doi.org/10.47552/ijam.v14i4.3967","url":null,"abstract":"Introduction: Shitapitta is a skin ailment that was first reported in Madhava Nidan which can be correlated to urticaria. It is a disorder characterized by symptoms comparable to Insect and scorpion bite, such as wheals resembling those from a wasp sting, itching, pain, fever, and burning feeling. Champakadi Agad is one of the Ayurveda formulations listed in Chapter 37/71-72 of Ashtanga Hridaya Uttarasthana by Acharya Vagbhata. Agadas are used to cure a variety of toxic conditions. Aims: To study the effect of Champakadi agad for local as well as internal use in case of Shitapitta. Case Report: This article is a case study about a 24 yrs old female patient who came to the OPD of Panchakarma Dept of Dr. D. Y. Patil College and hospital, Pimpri, Pune complaining of itchy skin, raised reddish bumps over the skin along with burning and pricing pain over her both palms and cheeks. She was treated with Champakadi Agad’s Local application for 30 days. Results after 30 days was found satisfactory. With no negative side effects, the therapy methods significantly reduced the disease's indications and symptoms. Discussion:This is a case study based on the management of Shitapitta (Urticaria). This study established the role of Champakadi Agad in the treatment of Shitapitta (Urticaria). Conclusion:The treatment of Shitapitta by Ayurvedic measures has been thoroughly examined and discussed here. Her progression is also shown here, step by step. This case study will encourage further research and aid in the development of an ayurvedic treatment protocol for Shitapitta (Urticaria).","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2024-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139629219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-07DOI: 10.47552/ijam.v14i4.3972
Queency Evangaline Sutnga, Savita S. Angadi, Innocent Sutnga
The condition known as Pittaja Mukhapaka is frequently encountered by patients seeking treatment at the outpatient department of the Ears, Nose, and Throat department. This condition is characterized by inflammation, ulceration, and a burning sensation in the oral mucosa, and is often associated with Aphthous ulcers (Pittaja Mukhapaka). Although modern medicine has several treatment options, including anti-inflammatory drugs, topical corticosteroids, and topical tetracyclines, these treatments have limitations. In contrast, Jatyadi Kwath Churna is a traditional polyherbal composition in ayurvedic medicine that has been used to treat oral problems for centuries. This herbal preparation contains Jati Patra, Guduchi, Draksha, Daru Haridra, Yavasa, Haritaki, Vibhitaki, Madhu, and Amlaki, and is indicated for oral problems in the texts Yogaratnakara and Bhaishajya Ratnavali. Material and Methods: This study aims to evaluate the efficacy of Jatyadi Kwatha Gandusha for Mukha Rogas, a study was conducted with 30 subjects randomly allocated to either Group A (receiving Gandusha of Jatyadi Kwatha and Madhu) or Group B (receiving Triphala Kwatha). Result: Both groups experienced complete relief from discomfort, burning sensations, and excessive salivation, on analysis between the groups with a statistically significant p-value results are equally effective in both groups. Conclusion: The study successfully demonstrated the effectiveness of Jatyadi Kwatha Gandusha and Triphala Kwatha in managing Pittaja Mukhapaka.
{"title":"Efficacy of Jatyadi Kwatha Gandusha in Management of Pittaja Mukhapaka with special reference to Aphthous Ulcer: A Randomized Controlled Clinical Trial","authors":"Queency Evangaline Sutnga, Savita S. Angadi, Innocent Sutnga","doi":"10.47552/ijam.v14i4.3972","DOIUrl":"https://doi.org/10.47552/ijam.v14i4.3972","url":null,"abstract":"The condition known as Pittaja Mukhapaka is frequently encountered by patients seeking treatment at the outpatient department of the Ears, Nose, and Throat department. This condition is characterized by inflammation, ulceration, and a burning sensation in the oral mucosa, and is often associated with Aphthous ulcers (Pittaja Mukhapaka). Although modern medicine has several treatment options, including anti-inflammatory drugs, topical corticosteroids, and topical tetracyclines, these treatments have limitations. In contrast, Jatyadi Kwath Churna is a traditional polyherbal composition in ayurvedic medicine that has been used to treat oral problems for centuries. This herbal preparation contains Jati Patra, Guduchi, Draksha, Daru Haridra, Yavasa, Haritaki, Vibhitaki, Madhu, and Amlaki, and is indicated for oral problems in the texts Yogaratnakara and Bhaishajya Ratnavali. Material and Methods: This study aims to evaluate the efficacy of Jatyadi Kwatha Gandusha for Mukha Rogas, a study was conducted with 30 subjects randomly allocated to either Group A (receiving Gandusha of Jatyadi Kwatha and Madhu) or Group B (receiving Triphala Kwatha). Result: Both groups experienced complete relief from discomfort, burning sensations, and excessive salivation, on analysis between the groups with a statistically significant p-value results are equally effective in both groups. Conclusion: The study successfully demonstrated the effectiveness of Jatyadi Kwatha Gandusha and Triphala Kwatha in managing Pittaja Mukhapaka.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2024-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139629251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-07DOI: 10.47552/ijam.v14i4.4058
Radhika Cheruvath, Rekha M Parmar
Systematic documentation of local health tradition related knowledge is important for validating and preserving medicinal heritage of any place. Lepidagathis keralensis Madhus. & NP Singh. is a species belonging to Acanthaceae family It is a perennial, prostrate, woody herb tenaciously attached to hard laterite soil. It is used by traditional practitioners of North Malabar for various ailments. Safety is of primary importance as far as any drug is concerned. No scientific data is available on the safety profile of this drug. Acute Oral toxicity study is the foremost step among toxicity studies. Hence this study was taken up. Aim & objective: To assess the Acute Oral Toxicity of water extract of Lepidagathis keralensis Madhus. & NP Singh. Materials and methods: Aqueous extract of the drug was orally administered in Wistar albino rats at different dose levels and various parameters for signs and symptoms of gross behavioural and physical changes starting from 30 minutes to 48 hours at various intervals were observed. Results and observations: The drug did not produce any signs of toxicity and mortality upto the dose of 2000 mg/kg in rats. Hence this drug which is extensively in use among traditional practitioners can be further studied and brought forward to main stream.
{"title":"Acute Oral Toxicity Study of Lepidagathis keralensis Madhus. & N.P.Singh","authors":"Radhika Cheruvath, Rekha M Parmar","doi":"10.47552/ijam.v14i4.4058","DOIUrl":"https://doi.org/10.47552/ijam.v14i4.4058","url":null,"abstract":"Systematic documentation of local health tradition related knowledge is important for validating and preserving medicinal heritage of any place. Lepidagathis keralensis Madhus. & NP Singh. is a species belonging to Acanthaceae family It is a perennial, prostrate, woody herb tenaciously attached to hard laterite soil. It is used by traditional practitioners of North Malabar for various ailments. Safety is of primary importance as far as any drug is concerned. No scientific data is available on the safety profile of this drug. Acute Oral toxicity study is the foremost step among toxicity studies. Hence this study was taken up. Aim & objective: To assess the Acute Oral Toxicity of water extract of Lepidagathis keralensis Madhus. & NP Singh. Materials and methods: Aqueous extract of the drug was orally administered in Wistar albino rats at different dose levels and various parameters for signs and symptoms of gross behavioural and physical changes starting from 30 minutes to 48 hours at various intervals were observed. Results and observations: The drug did not produce any signs of toxicity and mortality upto the dose of 2000 mg/kg in rats. Hence this drug which is extensively in use among traditional practitioners can be further studied and brought forward to main stream.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2024-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139629304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cachexia is a serious but under recognised consequence of many chronic diseases. The positive role of Ashwagandha in debility has been evaluated in several studies. But the underlying molecular mechanism is unclear. In the present study, network pharmacology is used to understand the molecular basis of its action. Methods: The phytoconstituents of Ashwagandha were screened from IMPPAT database and literature. The effective compounds were screened by drug likeness score and pharmacokinetic characteristics (ADMET). The target genes of effective compounds were predicted from BindingDB. The cachexia genes were found in gene-cards database, and cachexia related target genes were screened by comparison. Then the related pathways and correlation analysis were explored by the Genomes (KEGG) database. Finally, the networks of compound-target, target-pathway, and pathway-disease of Ashwagandha were constructed by Cytoscape software v3.7.2. Docking studies were carried out with PyRx software and analyzed in Biovia discovery studio visualizer. Results: The effective ingredients of Ashwagandha in cachexia were Withanolide S, Withanolide E, Withanolide D, Withasomniferol A and Beta sitosterol. The network analysis showed the highly modulating proteins were PTGS2, AR, PRKCB, JUN, TERT, NFE2L2, MDM2 and TNF which are related to cachexia and act on the pathways like MAPK signalling, MicroRNAs in cancer, cAMP signalling etc. The ligands and targets were retrieved from the PubChem, Protein Data Bank and docked using PyRx software. Conclusion: The present study is enabling to understand scientific evidence at the molecular level of balya action which has been proved clinically earlier.
{"title":"Insilico analysis of Ashwagandha (Withania somnifera (L.) Dunal) for its Balya activity with special reference to Cachexia","authors":"Vishala Hiremath, Giridhar Vedantam, Tripura Sahu, Peraira Jackulin Josephraj","doi":"10.47552/ijam.v14i4.4176","DOIUrl":"https://doi.org/10.47552/ijam.v14i4.4176","url":null,"abstract":"Cachexia is a serious but under recognised consequence of many chronic diseases. The positive role of Ashwagandha in debility has been evaluated in several studies. But the underlying molecular mechanism is unclear. In the present study, network pharmacology is used to understand the molecular basis of its action. Methods: The phytoconstituents of Ashwagandha were screened from IMPPAT database and literature. The effective compounds were screened by drug likeness score and pharmacokinetic characteristics (ADMET). The target genes of effective compounds were predicted from BindingDB. The cachexia genes were found in gene-cards database, and cachexia related target genes were screened by comparison. Then the related pathways and correlation analysis were explored by the Genomes (KEGG) database. Finally, the networks of compound-target, target-pathway, and pathway-disease of Ashwagandha were constructed by Cytoscape software v3.7.2. Docking studies were carried out with PyRx software and analyzed in Biovia discovery studio visualizer. Results: The effective ingredients of Ashwagandha in cachexia were Withanolide S, Withanolide E, Withanolide D, Withasomniferol A and Beta sitosterol. The network analysis showed the highly modulating proteins were PTGS2, AR, PRKCB, JUN, TERT, NFE2L2, MDM2 and TNF which are related to cachexia and act on the pathways like MAPK signalling, MicroRNAs in cancer, cAMP signalling etc. The ligands and targets were retrieved from the PubChem, Protein Data Bank and docked using PyRx software. Conclusion: The present study is enabling to understand scientific evidence at the molecular level of balya action which has been proved clinically earlier.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":null,"pages":null},"PeriodicalIF":0.2,"publicationDate":"2024-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139629486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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