Pub Date : 2023-07-03DOI: 10.47552/ijam.v14i2.3381
Sadhana Misar Wajpeyi, Premkumar P Badwaik
Backround-Panduroga is a Raktapradoshaja vyadhi having pitta dominance. Due to similarity of symptoms it can be correlated with Iron deficiency Anemia. Iron deficiency anemia secondary to inadequate dietary iron intake is caused by consuming a diet low in iron-rich foods. The richest sources of minerals and vitamins are fruits and green leafy vegetables. Growing a variety of crops in the kitchen garden is one of the simplest methods to make sure that everyone has access to a balanced meal that contains enough micronutrients. Aim and objectives-The objective of this study, which is being conducted in association with Mission Samriddhi (MS), is to compare the effectiveness of dietary supplements from Kitchen Garden (Parasbag) and Gudaharitaki Awaleha. Methodology- Total 60 patients were selected and divided in two equal groups. Group A patients were treated with nutritional supplement obtained from (Parasbag) Kitchen Garden along with Gudaharitaki Awaleha whereas group B patients were treated with Gudaharitaki Awaleha for 90 days. Assessment of subjective and objective criteria was done before and after treatment. Result and Discussion- Significant improvement was observed in subjective and objective parameters in both groups. But improvement was observed in more number of patients in group A than group B. Conclusion- Nutritional supplement obtained from (Parasbag) Kitchen Garden and Gudharitaki Awaleha improve Haemoglobin percentage because organically grown vegetables and fruits are rich in nutrients which help in prevention of nutritional deficiencies.
{"title":"Evaluation of comparative efficacy of Dietary supplement acquired from Kitchen Garden (Parasbag) and Gudharitaki Awaleha in Pandu Roga (Iron Deficiency Anemia)","authors":"Sadhana Misar Wajpeyi, Premkumar P Badwaik","doi":"10.47552/ijam.v14i2.3381","DOIUrl":"https://doi.org/10.47552/ijam.v14i2.3381","url":null,"abstract":"Backround-Panduroga is a Raktapradoshaja vyadhi having pitta dominance. Due to similarity of symptoms it can be correlated with Iron deficiency Anemia. Iron deficiency anemia secondary to inadequate dietary iron intake is caused by consuming a diet low in iron-rich foods. The richest sources of minerals and vitamins are fruits and green leafy vegetables. Growing a variety of crops in the kitchen garden is one of the simplest methods to make sure that everyone has access to a balanced meal that contains enough micronutrients. Aim and objectives-The objective of this study, which is being conducted in association with Mission Samriddhi (MS), is to compare the effectiveness of dietary supplements from Kitchen Garden (Parasbag) and Gudaharitaki Awaleha. Methodology- Total 60 patients were selected and divided in two equal groups. Group A patients were treated with nutritional supplement obtained from (Parasbag) Kitchen Garden along with Gudaharitaki Awaleha whereas group B patients were treated with Gudaharitaki Awaleha for 90 days. Assessment of subjective and objective criteria was done before and after treatment. Result and Discussion- Significant improvement was observed in subjective and objective parameters in both groups. But improvement was observed in more number of patients in group A than group B. Conclusion- Nutritional supplement obtained from (Parasbag) Kitchen Garden and Gudharitaki Awaleha improve Haemoglobin percentage because organically grown vegetables and fruits are rich in nutrients which help in prevention of nutritional deficiencies.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48272620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-03DOI: 10.47552/ijam.v14i2.3838
N. Bhatt, Abhijit Patil, M. Deshpande, Kirti Bhati
Research is most essential for professional development and growth of a sector particularly in the field of healthcare delivery. After more than 5 decades of expansive institutionalization ayurvedic education – learning and training – is faced with competitive capabilities. In a highly dynamic environment of career opportunities academic institutions are acquisitive to academic research for identity and sustainability. Academic research as a part of higher education in Ayurved has been a challenge due to several reasons, paradigm difference being the main. A pioneering effort undertaken by an Ayurvedic institute to improve its academic research performance with outsourced professional help had remarkable success. The activity driven by an expert with a change mechanism model with teacher, faculty as a focus, identified core issues and helped address it within the prevailing structure in a systematic manner. It innovatively developed measurable performance parameters for individual growth and outcome parameters for the institutional gains. It effectively helped bridge the gap between two parallel streams of principles and practices for research. The attempt elucidated the significance of academic research as an essential tool of learning and training beyond a mandatory requirement thereby evolving positive environment for research. This successful experiment could be utilized by other institutes and could be modified for its wider application for sustainable gains in terms of knowledge and competitiveness for acquiring academic professional efficiency in field of Ayurved.
{"title":"Improvising academic research in an Ayurved Institute: A promising experiment","authors":"N. Bhatt, Abhijit Patil, M. Deshpande, Kirti Bhati","doi":"10.47552/ijam.v14i2.3838","DOIUrl":"https://doi.org/10.47552/ijam.v14i2.3838","url":null,"abstract":"Research is most essential for professional development and growth of a sector particularly in the field of healthcare delivery. After more than 5 decades of expansive institutionalization ayurvedic education – learning and training – is faced with competitive capabilities. In a highly dynamic environment of career opportunities academic institutions are acquisitive to academic research for identity and sustainability. Academic research as a part of higher education in Ayurved has been a challenge due to several reasons, paradigm difference being the main. A pioneering effort undertaken by an Ayurvedic institute to improve its academic research performance with outsourced professional help had remarkable success. The activity driven by an expert with a change mechanism model with teacher, faculty as a focus, identified core issues and helped address it within the prevailing structure in a systematic manner. It innovatively developed measurable performance parameters for individual growth and outcome parameters for the institutional gains. It effectively helped bridge the gap between two parallel streams of principles and practices for research. The attempt elucidated the significance of academic research as an essential tool of learning and training beyond a mandatory requirement thereby evolving positive environment for research. This successful experiment could be utilized by other institutes and could be modified for its wider application for sustainable gains in terms of knowledge and competitiveness for acquiring academic professional efficiency in field of Ayurved.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41488079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-03DOI: 10.47552/ijam.v14i2.3458
G. V. Sathavane, Shweta Patil, A. Wankhede, Ankush Dikondwar
Yakrut is the Ayurvedic name for liver. It is involved in several physiological processes in the body, including metabolic activities, secretory, retention, purification, and elimination of foreign and endogenous materials. As a result, any impairment or degradation of its functionality leads to a wide range of liver problems. The principal hepatic illnesses that cause a high fatality rate include hepatotoxicity, jaundice, and hepatitis. Liver problems are still a growing health problem around the world. The treatment of liver problems using traditional or synthetic medications is ineffective and can have major negative impact.Ayurvedic herbal medicines, on the other hand, have a variety of possible benefits in liver diseases, despite the absence of a proven hepatoprotective medication in modern medicine. A variety of hepatoprotective herbs have been identified. In this review paper, we have attempted to collect and consolidate information on hepatoprotective herbs that will be useful in the Indian medical system. Keywords- Hepatoprotetive plants, Liver, Indian systems of medicine, Yakrut, Herbal drugs
{"title":"Hepatoprotective action of some Ayurvedic drugs: A review","authors":"G. V. Sathavane, Shweta Patil, A. Wankhede, Ankush Dikondwar","doi":"10.47552/ijam.v14i2.3458","DOIUrl":"https://doi.org/10.47552/ijam.v14i2.3458","url":null,"abstract":"Yakrut is the Ayurvedic name for liver. It is involved in several physiological processes in the body, including metabolic activities, secretory, retention, purification, and elimination of foreign and endogenous materials. As a result, any impairment or degradation of its functionality leads to a wide range of liver problems. The principal hepatic illnesses that cause a high fatality rate include hepatotoxicity, jaundice, and hepatitis. Liver problems are still a growing health problem around the world. The treatment of liver problems using traditional or synthetic medications is ineffective and can have major negative impact.Ayurvedic herbal medicines, on the other hand, have a variety of possible benefits in liver diseases, despite the absence of a proven hepatoprotective medication in modern medicine. A variety of hepatoprotective herbs have been identified. In this review paper, we have attempted to collect and consolidate information on hepatoprotective herbs that will be useful in the Indian medical system. \u0000Keywords- Hepatoprotetive plants, Liver, Indian systems of medicine, Yakrut, Herbal drugs","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47629782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-03DOI: 10.47552/ijam.v14i2.3555
S. Shewale, V. Undale, Vrushali Bhalchim, V. Patole, Snehal Satpute, Surabhi Jarare, Sakshi Sonawane
Background: Sansevieria cylindrica and Plumeria obtusa are used as a medicinal plant during intentional and unintentional accidental injuries. However, limited investigations have been performed to study pharmacological activities of these plants. Objectives: The current study designed at examining in-vitro anti-inflammatory and anti-oxidant effect of both plant extracts. Material & Method: Initially, the collection and authentication of both the plants performed. Phytochemical screening was done thereafter. Sansevieria cylindrica leaves and Plumeria obtusa seed pods were extracted using a combination of water and ethanol. Anti-inflammatory effect was assessed using membrane stabilization and protein denaturation assays. Anti-oxidant activity was measured by free radicals scavenging method using different reactive oxygen species producing reagents. Results: The dose dependent increase in anti-inflammatory and anti-oxidant activities were reported by both plants. Overall, Sansevieria cylindrica has shown higher rate of prevention of inflammation and oxidation compared to Plumeria obtusa extract. Both plants showed comparable anti-inflammatory and anti-oxidant activity in combination with that of reference drugs. Conclusion: The hydro-alcoholic extracts of Sansevieria cylindrica and Plumeria obtusa individually and also as 1:1 blend might be responsible for an anti-inflammatory and anti-oxidant activities.
{"title":"In-vitro anti-inflammatory and anti-oxidant study of Sansevieria cylindrica Bojer ex. Hook and Plumeria obtusa L. plants using different methods","authors":"S. Shewale, V. Undale, Vrushali Bhalchim, V. Patole, Snehal Satpute, Surabhi Jarare, Sakshi Sonawane","doi":"10.47552/ijam.v14i2.3555","DOIUrl":"https://doi.org/10.47552/ijam.v14i2.3555","url":null,"abstract":"Background: Sansevieria cylindrica and Plumeria obtusa are used as a medicinal plant during intentional and unintentional accidental injuries. However, limited investigations have been performed to study pharmacological activities of these plants. Objectives: The current study designed at examining in-vitro anti-inflammatory and anti-oxidant effect of both plant extracts. Material & Method: Initially, the collection and authentication of both the plants performed. Phytochemical screening was done thereafter. Sansevieria cylindrica leaves and Plumeria obtusa seed pods were extracted using a combination of water and ethanol. Anti-inflammatory effect was assessed using membrane stabilization and protein denaturation assays. Anti-oxidant activity was measured by free radicals scavenging method using different reactive oxygen species producing reagents. Results: The dose dependent increase in anti-inflammatory and anti-oxidant activities were reported by both plants. Overall, Sansevieria cylindrica has shown higher rate of prevention of inflammation and oxidation compared to Plumeria obtusa extract. Both plants showed comparable anti-inflammatory and anti-oxidant activity in combination with that of reference drugs. Conclusion: The hydro-alcoholic extracts of Sansevieria cylindrica and Plumeria obtusa individually and also as 1:1 blend might be responsible for an anti-inflammatory and anti-oxidant activities. ","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46635976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-03DOI: 10.47552/ijam.v14i2.3739
S. K, Vinay R Kadibagil
One of the lifestyle disorders that impacts 10% of the global population is gastric ulcer. H pylori infection, use of anti-inflammatory medications, cigarette smoking, chronic alcohol use, stress, and altered prostaglandin synthesis and E metabolism are the primary causes. Gastric ulcer signs are comparable to those of amlapitta (gastritis). Ayurvedic classics describe a variety of formulations, including churna (powder), kwatha(decoction), asavarishta (fermentation preparations), rasayoga (mineral preparations), and syrup, for the treatment of amlapitta. It is stated that amlapittaghna arka (distillate) can be used to treat amlapitta. Guduchi (Tinospora cordifolia), nimba (Azadiracta indica) and patola (Trichosanthus dioca) are the components of the amlapittaghna arka. Patients dislike the tikta rasa (bitter taste)of the medications on the above list. Syrup is the dosage form that is most commonly used across all patient age categories. Arka has been altered to take the form of syrup to increase the product's palatability and shelf life. Aspirin-induced gastric ulcers in Wistar albino rats were used in an experiment to measure the gastroprotective impact. pH, ulcer index, gastric juice volume, free acidity, total acidity, protein content, and carbohydrate content were among the biochemical indicators that changed.
{"title":"Gastro protective property of Amlapittagna syrup","authors":"S. K, Vinay R Kadibagil","doi":"10.47552/ijam.v14i2.3739","DOIUrl":"https://doi.org/10.47552/ijam.v14i2.3739","url":null,"abstract":"One of the lifestyle disorders that impacts 10% of the global population is gastric ulcer. H pylori infection, use of anti-inflammatory medications, cigarette smoking, chronic alcohol use, stress, and altered prostaglandin synthesis and E metabolism are the primary causes. Gastric ulcer signs are comparable to those of amlapitta (gastritis). Ayurvedic classics describe a variety of formulations, including churna (powder), kwatha(decoction), asavarishta (fermentation preparations), rasayoga (mineral preparations), and syrup, for the treatment of amlapitta. It is stated that amlapittaghna arka (distillate) can be used to treat amlapitta. Guduchi (Tinospora cordifolia), nimba (Azadiracta indica) and patola (Trichosanthus dioca) are the components of the amlapittaghna arka. Patients dislike the tikta rasa (bitter taste)of the medications on the above list. Syrup is the dosage form that is most commonly used across all patient age categories. Arka has been altered to take the form of syrup to increase the product's palatability and shelf life. Aspirin-induced gastric ulcers in Wistar albino rats were used in an experiment to measure the gastroprotective impact. pH, ulcer index, gastric juice volume, free acidity, total acidity, protein content, and carbohydrate content were among the biochemical indicators that changed.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49313173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-03DOI: 10.47552/ijam.v14i2.3524
Apeksha P Motghare, Parimal P. KATOLKAR, Tina S Lichade
Objective: A complex metabolic condition known as diabetes mellitus is caused by either inadequate or dysfunctional insulin. Once more, medicinal plants are being researched for the treatment of diabetes. Prototypical compounds found in medicinal plants have been the source of many conventional medications. The part of our investigation was to test the phytoconstituents of Manilkara hexandra for antidiabetic efficacy, in-silico. Methods: The pattern of interaction between the phytoconstituents from the Manilkara hexandra (Roxb.) Dubard, plant and the crystal structure of the antidiabetic proteins is evaluated using molecular docking in Discovery Studio (PDB ID: 4LY9). Later, SwissADME and pkCSM were used to screen for toxicity as well as the pharmacokinetic profile. Results: The docked results suggest that quercetin (-9.3 kcal/mol), kaempferol (-9.1 kcal/mol), p-coumaric acid (-6.4 kcal/mol) and cinnamic acid (-6.3 kcal/mol) for 4LY9 macromolecule has best binding towards antidiabetic activity as compared to the standard drug metformin (-5.0 kcal/mol). According to ADMET tests, pharmacokinetics and toxicity characteristics were also within acceptable bounds. Conclusion: Results from the binding potential of phytoconstituents aimed at antidiabetic activity were encouraging. It promotes the usage of Manilkara hexandra and offers crucial details on pharmaceutical research and clinical care.
{"title":"In-Silico Prediction of Phytoconstituents from Manilkara Hexandra for Antidiabetic Activity Targeting GKRP (Glucokinase Regulatory Protein)","authors":"Apeksha P Motghare, Parimal P. KATOLKAR, Tina S Lichade","doi":"10.47552/ijam.v14i2.3524","DOIUrl":"https://doi.org/10.47552/ijam.v14i2.3524","url":null,"abstract":"Objective: A complex metabolic condition known as diabetes mellitus is caused by either inadequate or dysfunctional insulin. Once more, medicinal plants are being researched for the treatment of diabetes. Prototypical compounds found in medicinal plants have been the source of many conventional medications. The part of our investigation was to test the phytoconstituents of Manilkara hexandra for antidiabetic efficacy, in-silico. Methods: The pattern of interaction between the phytoconstituents from the Manilkara hexandra (Roxb.) Dubard, plant and the crystal structure of the antidiabetic proteins is evaluated using molecular docking in Discovery Studio (PDB ID: 4LY9). Later, SwissADME and pkCSM were used to screen for toxicity as well as the pharmacokinetic profile. Results: The docked results suggest that quercetin (-9.3 kcal/mol), kaempferol (-9.1 kcal/mol), p-coumaric acid (-6.4 kcal/mol) and cinnamic acid (-6.3 kcal/mol) for 4LY9 macromolecule has best binding towards antidiabetic activity as compared to the standard drug metformin (-5.0 kcal/mol). According to ADMET tests, pharmacokinetics and toxicity characteristics were also within acceptable bounds. Conclusion: Results from the binding potential of phytoconstituents aimed at antidiabetic activity were encouraging. It promotes the usage of Manilkara hexandra and offers crucial details on pharmaceutical research and clinical care. ","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44609084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-03DOI: 10.47552/ijam.v14i2.3464
K. Mishra, J. Changade, Ashwini D Sonalkar
Background: Polycystic ovarian disease (PCOD) is a complex heterogeneous disorder with involvement of endocrinopathies. Ayurveda does not correlate the condition to a single disease or syndrome but the symptoms bears a resemblance to involvement of Vata and Kapha Doshas. Ayurveda treats Poly Cystic Ovarian Disorder by correcting basic disturbances in metabolism, by restoring ovulation naturally by speeding up growth of follicles. The line of treatment for PCOS patient depends on the body constitution of patient, causative factors and symptoms shown. Case report: A 25-years female patient with her husband aged 28 years reported the OPD of Prasuti Tantra evam Streeroga, with the complaints of dysmenorrhoea, scanty menses, delayed menses, acidity, hairfall, and general weakness. Her ultrasonography reports revealed poly cystic like appearance of ovaries. Her menstrual cycle was 2 days/ 45 days, scanty, painful with few clots. Obstetric history was nil. Patient was given Kuberaksha vati, Kalaonji powder, Rasapachak kwatha, Granthiraja powder, and Navayas Churna for 4 months with followup taken every month. Result: After treatment, patients menstrual cycle was set gradually to normal i.e. 28 days. Her interval between menses was reduced. Significant relief was achieved in complaints of dysmenorrhoea and clots. Even her USG findings showed normal appearance of ovaries after treatment. Conclusion: This case supports the importance of personalised medication in management of poly cystic disorder. It also emphasizes the significance of Kuberaksha vati, Kalaonji powder, Rasapachak kwatha, Granthiraja powder, and Navayas Churna in reducing subjective ad objective signs and symptoms of Poly Cystic Ovarian Disorder. Further large scale clinic trial scan be helpful for drawing further conclusions.
{"title":"Ayurvedic management of Polycystic Ovarian Disorder - A case study","authors":"K. Mishra, J. Changade, Ashwini D Sonalkar","doi":"10.47552/ijam.v14i2.3464","DOIUrl":"https://doi.org/10.47552/ijam.v14i2.3464","url":null,"abstract":"Background: Polycystic ovarian disease (PCOD) is a complex heterogeneous disorder with involvement of endocrinopathies. Ayurveda does not correlate the condition to a single disease or syndrome but the symptoms bears a resemblance to involvement of Vata and Kapha Doshas. Ayurveda treats Poly Cystic Ovarian Disorder by correcting basic disturbances in metabolism, by restoring ovulation naturally by speeding up growth of follicles. The line of treatment for PCOS patient depends on the body constitution of patient, causative factors and symptoms shown. Case report: A 25-years female patient with her husband aged 28 years reported the OPD of Prasuti Tantra evam Streeroga, with the complaints of dysmenorrhoea, scanty menses, delayed menses, acidity, hairfall, and general weakness. Her ultrasonography reports revealed poly cystic like appearance of ovaries. Her menstrual cycle was 2 days/ 45 days, scanty, painful with few clots. Obstetric history was nil. Patient was given Kuberaksha vati, Kalaonji powder, Rasapachak kwatha, Granthiraja powder, and Navayas Churna for 4 months with followup taken every month. Result: After treatment, patients menstrual cycle was set gradually to normal i.e. 28 days. Her interval between menses was reduced. Significant relief was achieved in complaints of dysmenorrhoea and clots. Even her USG findings showed normal appearance of ovaries after treatment. Conclusion: This case supports the importance of personalised medication in management of poly cystic disorder. It also emphasizes the significance of Kuberaksha vati, Kalaonji powder, Rasapachak kwatha, Granthiraja powder, and Navayas Churna in reducing subjective ad objective signs and symptoms of Poly Cystic Ovarian Disorder. Further large scale clinic trial scan be helpful for drawing further conclusions.","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48130456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-03DOI: 10.47552/ijam.v14i2.3383
I. Gaikwad, Sadhana Misar Wajpeyi
Background: Osteoarthritis (OA) is a progressive musculoskeletal disease involving the degeneration of cartilage and bone, and is one of the leading causes of pain and disability worldwide. It is a multi-factorial, slowly progressing, and primarily non-inflammatory degenerative disorder of the synovial joints that is often age related and/or trauma induced. Women are more prone than men. It rises in prevalence, incidence, and severity with polyarticular involvement following menopause. Aim and Objectives: To evaluate the association between early menopause and incidence of Osteoarthritis in patients of Wardha District. Methodology: A cross sectional study was conducted among 60 post-menopausal female subjects having normal menopause and early menopause between the age group of 50 to 75 years of Wardha District. Group A comprised normal menopause subjects and Group B comprised early menopausal subjects. Then incidence of Osteoarthritis in both groups was assessed on the basis of diagnostic criteria by filling predesigned proforma and comparison was done by statistical analysis. Observation and Discussion: Patients of group B showed diagnostic features of Osteoarthritis like crepitus, restricted range of movement , bony enlargement and morning stiffness <30 minutes in more number of patient as compared to group A. This clearly indicates that incidence of Osteoarthritis was more in patients having early menopause as compared to normal menopause. Conclusion: This study concluded that there is strong association between early menopause and occurrence of Osteoarthritis.
{"title":"Association between early menopause and incidence of Osteoarthritis in patients of Wardha district - An observational study","authors":"I. Gaikwad, Sadhana Misar Wajpeyi","doi":"10.47552/ijam.v14i2.3383","DOIUrl":"https://doi.org/10.47552/ijam.v14i2.3383","url":null,"abstract":"Background: Osteoarthritis (OA) is a progressive musculoskeletal disease involving the degeneration of cartilage and bone, and is one of the leading causes of pain and disability worldwide. It is a multi-factorial, slowly progressing, and primarily non-inflammatory degenerative disorder of the synovial joints that is often age related and/or trauma induced. Women are more prone than men. It rises in prevalence, incidence, and severity with polyarticular involvement following menopause. Aim and Objectives: To evaluate the association between early menopause and incidence of Osteoarthritis in patients of Wardha District. Methodology: A cross sectional study was conducted among 60 post-menopausal female subjects having normal menopause and early menopause between the age group of 50 to 75 years of Wardha District. Group A comprised normal menopause subjects and Group B comprised early menopausal subjects. Then incidence of Osteoarthritis in both groups was assessed on the basis of diagnostic criteria by filling predesigned proforma and comparison was done by statistical analysis. Observation and Discussion: Patients of group B showed diagnostic features of Osteoarthritis like crepitus, restricted range of movement , bony enlargement and morning stiffness <30 minutes in more number of patient as compared to group A. This clearly indicates that incidence of Osteoarthritis was more in patients having early menopause as compared to normal menopause. Conclusion: This study concluded that there is strong association between early menopause and occurrence of Osteoarthritis. ","PeriodicalId":13751,"journal":{"name":"International Journal of Ayurvedic Medicine","volume":" ","pages":""},"PeriodicalIF":0.2,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48230841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-04DOI: 10.47552/ijam.v14i1.3316
A. Raj, Rabina Acharya, B. Patel, S. Pawar
Genotoxic substances are those which are capable to induce a destructive effect on a cell’s genetic material. It can be either carcinogen, mutagen, teratogen or cytotoxic depending upon the dose, duration and mode of usage. Mutations may manifest in many forms as duplication, deletion or insertion. However, all mutagens are genotoxic, not all genotoxins induce mutations. Currently traditional medicines and plant drugs are used across the globe without strict medical supervision. In a country like India, folklore medicines play a pivot role in health sector. Irrational long-term usage of any plant-based drug are capable to induce adverse reactions. Till date there is no single hand information about the genotoxic effects of medicinal plants used in Ayurveda. Many of the drugs reported for toxicity are potent drug candidates in Ayurveda. From the available literature 184 articles reported the genotoxicity of medicinal plants. After shortlisting with the inclusion and exclusion criteria’s 57 articles are found to be on genotoxic potential of medicinal plants. Present review reports genotoxic effect of 32 drugs used either as single or combination. It contains various array of drugs, for example poisonous drugs like Arka, Dhattura, Mandookaparni – which is a medhya rasayana, Guduchi – which is a potent immunomodulator and so on. Among them a few drugs like Palandu, Tanduleeyaka, Misreya, Chandrasoora, Sariba, Manjishta, Dadima, Guduchi etc. need special attention. This article tries to provide an insight on the reported genotoxic effect of plants used in Ayurveda.
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Pub Date : 2023-04-04DOI: 10.47552/ijam.v14i1.3327
Iliyasu Zanna, Y. Ibrahim, I. Nasir, M. Attah
Objective: The use of ethnobiology in treatment of many diseases especially in rural residents with limited access to medical technology, treatment and equipment is beneficial and necessary. Daucus carota (DC) root extract was used as pre-treatment in adult Wistar rats exposed to diclofenac sodium (DF) to investigate a protective effect on the histology of liver, kidney and duodenum. Materials and Method: Twenty-five adult Wistar rats were used for this study and were randomly divided into 5 groups of 5 rats each, which included: Group A - Normal control; Group B – 50mg/kg DF control; Group C – 50mg/kg DC + 50mg/kg DF, Group D – 100mg/kg DC + 50mg/kg DF; and, Group E – 140mg/kg DC + 50mg/kg DC. Results and Discussion: The results showed a reduction in damage to the hepatocytes, maintenance of sinusoidal integrity and reduction in the number of inflammatory cells in the hepatic parenchyma, In the kidney tissue, the extract preserved the glomerular capillary tuft, renal tubular epithelial cells, conserved Bowman’s space and lining epithelium of the capsule in a dose dependent manner. The intestinal mucosa in groups treated with higher doses of the extract were completely preserved and intact with minimal erosion of epithelial lining along with preservation of lamina propria and intestinal glands. Conclusion: Pre-administration of DC, preferably at concentrations of 100mg/kg and 140mg/kg reduced hepatotoxicity, renal tissue and mucosal layer damage in the duodenum following administration of DF. This preservation of tissues improved as concentration of the extract increased verifying that its efficiency was dose dependent.
目的：利用民族生物学治疗许多疾病，特别是在获得医疗技术、治疗和设备有限的农村居民中，是有益和必要的。采用颈豆根提取物对暴露于双氯芬酸钠（DF）的成年Wistar大鼠进行预处理，研究其对肝、肾和十二指肠组织学的保护作用。材料与方法：本研究选用成年Wistar大鼠25只，随机分为5组，每组5只，包括：A组-正常对照组；B组50mg/kg DF对照组；C组–50mg/kg DC + 50mg/kg DF，D组–100mg/kg DC + 50mg/kg DF；E组为140mg/kg DC+50mg/kg DC。结果与讨论：结果显示，肝细胞损伤减少，肝实质中正弦完整性得到维持，炎症细胞数量减少。在肾组织中，提取物以剂量依赖的方式保留了肾小球毛细血管簇、肾小管上皮细胞、鲍曼间隙和包膜衬里上皮。用高剂量提取物处理的组的肠粘膜得到了完全保存和完整，上皮衬里的侵蚀最小，固有层和肠腺也得到了保存。结论：DC预给药，最好是100mg/kg和140mg/kg的浓度，可以降低DF给药后的肝毒性、肾组织和十二指肠粘膜层损伤。这种组织保存随着提取物浓度的增加而改善，验证了其效率是剂量依赖性的。
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