Pub Date : 2024-07-01DOI: 10.31782/ijcrr.2024.161401
Febin P Baby, Kumar Sumit
Objectives: The objective of the study is to understand and explore the beneficiaries’ perceptions regarding reproductive health care services in Thrissur. Methods: A predesigned in-depth interview guide were prepared to collect the data for the qualitative cross-sectional study. Data collected in two-phase, in the first phase data collected from the 15 reproductive beneficiaries in the private hospitals and in second phase data collected from the 13 public hospital beneficiaries identified from the community level, those who recently utilized the public hospitals. Results: The significant problems by private hospital beneficiaries towards government hospitals are the lousy behavior of the medical staff and cleanliness. However, Public hospital beneficiaries are satisfied with the services and treatments provided. The primary concerns by the private hospital beneficiaries towards the public hospitals are contradicting in the present reality and major problems concerned towards public hospitals are not seen Conclusion: Both private and government hospitals in Thrissur providing excellent services in reproductive cases. Public hospitals have various limitations, such as less infrastructure, workforce, and technical availability. However, within limits, public hospitals are delivering an excellent service in recent times. Key Words: Patient satisfaction, Private hospitals, Public hospitals
{"title":"A Study on Public Perception Towards Reproductive Care Services in Health Care Facilities in Kerala, India","authors":"Febin P Baby, Kumar Sumit","doi":"10.31782/ijcrr.2024.161401","DOIUrl":"https://doi.org/10.31782/ijcrr.2024.161401","url":null,"abstract":"Objectives: The objective of the study is to understand and explore the beneficiaries’ perceptions regarding reproductive health care services in Thrissur. Methods: A predesigned in-depth interview guide were prepared to collect the data for the qualitative cross-sectional study. Data collected in two-phase, in the first phase data collected from the 15 reproductive beneficiaries in the private hospitals and in second phase data collected from the 13 public hospital beneficiaries identified from the community level, those who recently utilized the public hospitals. Results: The significant problems by private hospital beneficiaries towards government hospitals are the lousy behavior of the medical staff and cleanliness. However, Public hospital beneficiaries are satisfied with the services and treatments provided. The primary concerns by the private hospital beneficiaries towards the public hospitals are contradicting in the present reality and major problems concerned towards public hospitals are not seen Conclusion: Both private and government hospitals in Thrissur providing excellent services in reproductive cases. Public hospitals have various limitations, such as less infrastructure, workforce, and technical availability. However, within limits, public hospitals are delivering an excellent service in recent times. Key Words: Patient satisfaction, Private hospitals, Public hospitals","PeriodicalId":13809,"journal":{"name":"International Journal of Current Research and Review","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141847788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.31782/ijcrr.2024.161402
Urszula Łapińska, Ewelina Machała-Ćwikła, Kamila Machała, Dominika Machała, Piotr Ćwikła, Piotr Zdziebło, Rafał Łapiński
Bruxism is a condition characterized by excessive grinding and clenching of teeth especially during sleep, but symptoms can also occur during the day. Bruxism causes fatigue, feelings of sleeplessness, increased muscle tension and pain in the chewing muscle area. Despite its high prevalence in the adult population (it is believed to occur in up to one-third of people), we do not know the exact path of mechanism behind the disease, and treatment methods are not clearly defined. Treatment methods used include drug therapies, biofeedback, kinesitherapy, physiotherapy, intramuscular and intra-articular injections, psychological therapy, and treatment with intraoral devices. In addition, the exact diagnostic pathway and the way how to classify the severity of bruxism symptoms have not been determined. There is still no answer to the question of what procedure to introduce in a patient who is experiencing symptoms of bruxism despite full dental rehabilitation. The age at which treatment should begin also remains unclear. Further research is needed on the etiology of bruxism, as well as the development of uniform recommendations for diagnosis and therapy.
{"title":"Potential Methods for Alleviating Symptoms of Bruxism","authors":"Urszula Łapińska, Ewelina Machała-Ćwikła, Kamila Machała, Dominika Machała, Piotr Ćwikła, Piotr Zdziebło, Rafał Łapiński","doi":"10.31782/ijcrr.2024.161402","DOIUrl":"https://doi.org/10.31782/ijcrr.2024.161402","url":null,"abstract":"Bruxism is a condition characterized by excessive grinding and clenching of teeth especially during sleep, but symptoms can also occur during the day. Bruxism causes fatigue, feelings of sleeplessness, increased muscle tension and pain in the chewing muscle area. Despite its high prevalence in the adult population (it is believed to occur in up to one-third of people), we do not know the exact path of mechanism behind the disease, and treatment methods are not clearly defined. Treatment methods used include drug therapies, biofeedback, kinesitherapy, physiotherapy, intramuscular and intra-articular injections, psychological therapy, and treatment with intraoral devices. In addition, the exact diagnostic pathway and the way how to classify the severity of bruxism symptoms have not been determined. There is still no answer to the question of what procedure to introduce in a patient who is experiencing symptoms of bruxism despite full dental rehabilitation. The age at which treatment should begin also remains unclear. Further research is needed on the etiology of bruxism, as well as the development of uniform recommendations for diagnosis and therapy.","PeriodicalId":13809,"journal":{"name":"International Journal of Current Research and Review","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141852227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
There are risks in every construction project, uncontrolled risks will become a problem and cause losses to the project due to cost overruns and delays in work execution. Therefore, to manage risk, it is necessary to carry out risk management so that the project can survive, or perhaps optimize risk. The purpose of this study was to determine the dominant risk factors, how big the level of risk that occurred and the response given to the dominant risks of cost and time performance in the structural work of the Grand Jati Junction Apartment Development project. From the results of this study, it was found that 8 factors became the dominant risk factors with varying (different) levels depending on the complexity of the work and the conditions at the time of implementation of each stage of the work. Then from the results of the risk factor analysis, a risk response is obtained in the form of preventive measures to prevent or minimize these risks. Keywords: Risk Management, Building Structure Work.
{"title":"Effect of Implementation of Performance Risk Management on High Rise Building Structure Work (Junction City Building)","authors":"Mahliza Nasution","doi":"10.52403/ijrr.20231109","DOIUrl":"https://doi.org/10.52403/ijrr.20231109","url":null,"abstract":"There are risks in every construction project, uncontrolled risks will become a problem and cause losses to the project due to cost overruns and delays in work execution. Therefore, to manage risk, it is necessary to carry out risk management so that the project can survive, or perhaps optimize risk. The purpose of this study was to determine the dominant risk factors, how big the level of risk that occurred and the response given to the dominant risks of cost and time performance in the structural work of the Grand Jati Junction Apartment Development project. From the results of this study, it was found that 8 factors became the dominant risk factors with varying (different) levels depending on the complexity of the work and the conditions at the time of implementation of each stage of the work. Then from the results of the risk factor analysis, a risk response is obtained in the form of preventive measures to prevent or minimize these risks. Keywords: Risk Management, Building Structure Work.","PeriodicalId":13809,"journal":{"name":"International Journal of Current Research and Review","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135872988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction: Diabetic retinopathy (DR) is a significant public health concern affecting individuals with diabetes mellitus (DM). Despite treatment advances, a substantial proportion of patients do not respond adequately. This study investigates risk factors associated with the progression of non-proliferative diabetic retinopathy (NPDR) to proliferative diabetic retinopathy (PDR) in type-2 diabetes patients. Methods: A retrospective case-control study was conducted on diabetic patients older than 40 years with at least 5 years of Type-2 Diabetes Mellitus history, attending ophthalmology clinic in Government Medical College, Thrissur, a tertiary care hospital. Data from patients with retinal examination showing diabetic retinopathy were analyzed. Records with missing data were excluded. Patients with Proliferative Diabetic Retinopathy (n=153) were compared with those having Non- Proliferative Diabetic Retinopathy (n=230). Various risk factors were assessed using statistical analysis. Results: Among the studied variables, sex, duration of diabetes, serum urea, serum creatinine, serum triglycerides, and chronic kidney disease were significantly different between Proliferative Diabetic Retinopathy and Non-Proliferative Diabetic Retinopathy patients. Binary logistic regression revealed that duration of diabetes (OR = 1.8, 95% CI = 1.1 - 2.39) and serum creatinine (OR =1.8, 95% CI = 1.1 - 2.39) independently influenced Proliferative Diabetic Retinopathy development. Conclusion: This study highlights that longer diabetes duration and elevated serum creatinine levels independently increase the risk of Non- Proliferative Diabetic Retinopathy progressing to Proliferative Diabetic Retinopathy in type-2 diabetic patients. Other factors such as age, gender, hyperlipidemia, systemic hypertension, type of diabetic treatment, and history of ischemic heart disease did not show significant associations with disease progression. These findings emphasize the importance of close monitoring, early detection, and intervention in patients with Non- Proliferative Diabetic Retinopathy, particularly those with a longer diabetic history, to prevent Proliferative Diabetic Retinopathy development. Further research should explore the causal relationship between serum creatinine and diabetic retinopathy progression and evaluate the impact of renal disease management on disease outcomes. Keywords: Diabetic Retinopathy, diabetes mellitus (DM), Type-2 Diabetes Mellitus (T2DM).
糖尿病视网膜病变(DR)是影响糖尿病(DM)患者的重大公共卫生问题。尽管治疗取得了进展，但相当大比例的患者没有充分的反应。本研究探讨了2型糖尿病患者非增殖性糖尿病视网膜病变(NPDR)向增殖性糖尿病视网膜病变(PDR)发展的相关危险因素。方法:采用回顾性病例对照研究，选取在三级医院特里苏瑟政府医学院眼科门诊就诊的年龄大于40岁且有5年以上2型糖尿病病史的糖尿病患者。分析了糖尿病视网膜病变患者的视网膜检查数据。数据缺失的记录被排除。153例增殖性糖尿病视网膜病变患者与230例非增殖性糖尿病视网膜病变患者进行比较。采用统计学方法对各种危险因素进行评估。结果:在研究变量中，性别、糖尿病病程、血清尿素、血清肌酐、血清甘油三酯、慢性肾脏疾病在增殖性糖尿病视网膜病变与非增殖性糖尿病视网膜病变患者之间存在显著差异。二元logistic回归显示，糖尿病病程(OR =1.8, 95% CI = 1.1 - 2.39)和血清肌酐(OR =1.8, 95% CI = 1.1 - 2.39)独立影响增生性糖尿病视网膜病变的发展。结论:本研究强调2型糖尿病患者糖尿病病程延长和血清肌酐水平升高可独立增加非增殖性糖尿病视网膜病变发展为增殖性糖尿病视网膜病变的风险。其他因素如年龄、性别、高脂血症、全身性高血压、糖尿病治疗类型和缺血性心脏病史与疾病进展无显著相关性。这些发现强调了密切监测、早期发现和干预非增殖性糖尿病视网膜病变患者的重要性，特别是那些有较长糖尿病病史的患者，以防止增殖性糖尿病视网膜病变的发展。进一步的研究应探讨血清肌酐与糖尿病视网膜病变进展之间的因果关系，并评估肾脏疾病管理对疾病结局的影响。关键词:糖尿病视网膜病变，糖尿病，2型糖尿病
{"title":"Study on Risk Factors Associated with Severity of Diabetic Retinopathy in Type-2 Diabetic Patients, Attending a Tertiary Care Centre in Kerala","authors":"Nandini Varma, Sinumol Thulaseedharan","doi":"10.52403/ijrr.20231116","DOIUrl":"https://doi.org/10.52403/ijrr.20231116","url":null,"abstract":"Introduction: Diabetic retinopathy (DR) is a significant public health concern affecting individuals with diabetes mellitus (DM). Despite treatment advances, a substantial proportion of patients do not respond adequately. This study investigates risk factors associated with the progression of non-proliferative diabetic retinopathy (NPDR) to proliferative diabetic retinopathy (PDR) in type-2 diabetes patients. Methods: A retrospective case-control study was conducted on diabetic patients older than 40 years with at least 5 years of Type-2 Diabetes Mellitus history, attending ophthalmology clinic in Government Medical College, Thrissur, a tertiary care hospital. Data from patients with retinal examination showing diabetic retinopathy were analyzed. Records with missing data were excluded. Patients with Proliferative Diabetic Retinopathy (n=153) were compared with those having Non- Proliferative Diabetic Retinopathy (n=230). Various risk factors were assessed using statistical analysis. Results: Among the studied variables, sex, duration of diabetes, serum urea, serum creatinine, serum triglycerides, and chronic kidney disease were significantly different between Proliferative Diabetic Retinopathy and Non-Proliferative Diabetic Retinopathy patients. Binary logistic regression revealed that duration of diabetes (OR = 1.8, 95% CI = 1.1 - 2.39) and serum creatinine (OR =1.8, 95% CI = 1.1 - 2.39) independently influenced Proliferative Diabetic Retinopathy development. Conclusion: This study highlights that longer diabetes duration and elevated serum creatinine levels independently increase the risk of Non- Proliferative Diabetic Retinopathy progressing to Proliferative Diabetic Retinopathy in type-2 diabetic patients. Other factors such as age, gender, hyperlipidemia, systemic hypertension, type of diabetic treatment, and history of ischemic heart disease did not show significant associations with disease progression. These findings emphasize the importance of close monitoring, early detection, and intervention in patients with Non- Proliferative Diabetic Retinopathy, particularly those with a longer diabetic history, to prevent Proliferative Diabetic Retinopathy development. Further research should explore the causal relationship between serum creatinine and diabetic retinopathy progression and evaluate the impact of renal disease management on disease outcomes. Keywords: Diabetic Retinopathy, diabetes mellitus (DM), Type-2 Diabetes Mellitus (T2DM).","PeriodicalId":13809,"journal":{"name":"International Journal of Current Research and Review","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135873086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In recent years, skincare industry has grown rapidly in Indonesia. The growing number of skincare users in Indonesia becomes an opportunity for skincare producers in Indonesia, which is dominated by MSMEs. PT Nectars Natura Karya is one of MSMEs that consistently produce and promote the usage of natural skincare and sustainable products. Like other MSMEs, in particular, Covid-19 pandemic had impacted PT Nectars Natura Karya’s business as their sales dropped 30 percent in 2020. Based on those problems, PT Nectars Natura Karya needs to improve the resilience of their business in this post-Covid era. This research aims to identify strategic priorities for PT Nectars Natura Karya to compete with competitors and stay relevant in the market. In order to answer the research question, this research used the EFE and IFE Matrix to identify and evaluate external and internal factors. In the matching stage, external and internal factors were used to generate feasible alternative strategies for PT Nectars Natura Karya. In this stage, the author used IE and SWOT Matrix to formulate alternative strategies. To determine the best strategies for PT Nectars Natura Karya, the author used AHP and TOPSIS methods. The results explain implementing digital marketing and increasing their digital literacy is the best option for PT Nectars Natura Karya. Digital literacy has already become a “have-to-have” skill for SMEs since most of consumers interact and buy products through digital platforms. Keywords: AHP, MSMEs, natural skincare, PT Nectars Natura Karya, TOPSIS
近年来，印尼的护肤品行业发展迅速。印尼护肤品用户数量的不断增长，为以中小微企业为主的印尼护肤品生产商提供了机会。PT Nectars Natura Karya是一家持续生产和推广天然护肤品和可持续产品的中小微企业。与其他中小微企业一样，新冠疫情对PT Nectars Natura Karya的业务造成了影响，该公司2020年的销售额下降了30%。基于这些问题，PT Nectars Natura Karya需要提高其业务在后新冠时代的弹性。本研究旨在确定PT Nectars Natura Karya与竞争对手竞争并保持市场相关性的战略重点。为了回答研究问题，本研究使用EFE和IFE矩阵来识别和评价外部和内部因素。在匹配阶段，利用外部因素和内部因素对PT Nectars Natura Karya产生可行的备选策略。在这一阶段，作者使用IE和SWOT矩阵来制定备选策略。采用层次分析法和TOPSIS法确定了自然花蜜的最佳策略。结果说明实施数字营销和提高他们的数字素养是PT Nectars Natura Karya的最佳选择。由于大多数消费者通过数字平台互动和购买产品，数字素养已经成为中小企业“必备”的技能。关键词:层次分析法，中小微企业，天然护肤，PT花蜜，TOPSIS
{"title":"The Development Strategy of Natural Skincare (Case Study PT Nectars Natura Karya)","authors":"Yazid Hilmi Lubis, R. Dikky Indrawan, Rokhani .","doi":"10.52403/ijrr.20231110","DOIUrl":"https://doi.org/10.52403/ijrr.20231110","url":null,"abstract":"In recent years, skincare industry has grown rapidly in Indonesia. The growing number of skincare users in Indonesia becomes an opportunity for skincare producers in Indonesia, which is dominated by MSMEs. PT Nectars Natura Karya is one of MSMEs that consistently produce and promote the usage of natural skincare and sustainable products. Like other MSMEs, in particular, Covid-19 pandemic had impacted PT Nectars Natura Karya’s business as their sales dropped 30 percent in 2020. Based on those problems, PT Nectars Natura Karya needs to improve the resilience of their business in this post-Covid era. This research aims to identify strategic priorities for PT Nectars Natura Karya to compete with competitors and stay relevant in the market. In order to answer the research question, this research used the EFE and IFE Matrix to identify and evaluate external and internal factors. In the matching stage, external and internal factors were used to generate feasible alternative strategies for PT Nectars Natura Karya. In this stage, the author used IE and SWOT Matrix to formulate alternative strategies. To determine the best strategies for PT Nectars Natura Karya, the author used AHP and TOPSIS methods. The results explain implementing digital marketing and increasing their digital literacy is the best option for PT Nectars Natura Karya. Digital literacy has already become a “have-to-have” skill for SMEs since most of consumers interact and buy products through digital platforms. Keywords: AHP, MSMEs, natural skincare, PT Nectars Natura Karya, TOPSIS","PeriodicalId":13809,"journal":{"name":"International Journal of Current Research and Review","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135872985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P. Srikanth Reddy, V. Alagarsamy, P. Subhash Chandra Bose
The current study aims to construct a perphenazine oral nanosuspension utilizing the solvent evaporation technique with a variety of stabilizers and surfactants, including PVPK30, Pluronic F127, urea, and SLS. In order to obtain desired size and saturation solubility, several as well as process factors were tuned. Particle size, zeta potential, saturation solubility, dissolving rate, morphological study (SEM), and in-vitro dissolution study were all used to characterize the produced Nanosuspension. The improved formulation's (F12) zeta potential value was discovered to be -7mv, which was determined to be within acceptable bounds. It was discovered that the average particle size of optimal formulations (F12) in nanosuspension was 118 nm. According to the in vitro investigations, formulation F12 exhibits the greatest 98.65% of the medication is released within 30 minutes. The drug was not released for minutes by any of the other formulations. Understanding how the release of drugs via Nanosuspension functioned was aided by the application of mathematical formulae that included zero out, and first out, method equation. R2 analysis revealed that the enhanced 1st order kinetics by F12. Keywords: Perphenazine, PVPK-30, Poloxamer 184, Pluronic F127, Urea, SLS.
{"title":"Preparation, Characterization and In Vitro Evaluation of Nanosuspension for the Treatment of Schizophrenia","authors":"P. Srikanth Reddy, V. Alagarsamy, P. Subhash Chandra Bose","doi":"10.52403/ijrr.20231106","DOIUrl":"https://doi.org/10.52403/ijrr.20231106","url":null,"abstract":"The current study aims to construct a perphenazine oral nanosuspension utilizing the solvent evaporation technique with a variety of stabilizers and surfactants, including PVPK30, Pluronic F127, urea, and SLS. In order to obtain desired size and saturation solubility, several as well as process factors were tuned. Particle size, zeta potential, saturation solubility, dissolving rate, morphological study (SEM), and in-vitro dissolution study were all used to characterize the produced Nanosuspension. The improved formulation's (F12) zeta potential value was discovered to be -7mv, which was determined to be within acceptable bounds. It was discovered that the average particle size of optimal formulations (F12) in nanosuspension was 118 nm. According to the in vitro investigations, formulation F12 exhibits the greatest 98.65% of the medication is released within 30 minutes. The drug was not released for minutes by any of the other formulations. Understanding how the release of drugs via Nanosuspension functioned was aided by the application of mathematical formulae that included zero out, and first out, method equation. R2 analysis revealed that the enhanced 1st order kinetics by F12. Keywords: Perphenazine, PVPK-30, Poloxamer 184, Pluronic F127, Urea, SLS.","PeriodicalId":13809,"journal":{"name":"International Journal of Current Research and Review","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135872993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tourism serves as a catalyst for unlocking the unique potential and distinctiveness of specific regions, thereby fostering holistic well-being, particularly for the local economy. Kampoeng Djadhoel, situated in Semarang City's Rejomulyo Village, East Semarang District, is poised to fulfil this potential. Under the stewardship of an evolving Tourism Awareness Group (Pokdarwis), it aspires to transform into an enticing destination for both local and international visitors. To achieve this vision, it is essential to deepen our understanding of village management and actively engage the community. This study is a comprehensive exploration encompassing three critical domains: tourism village management, community participation, and identifying inhibiting and supporting factors. Employing a Descriptive Qualitative methodology, our investigation underscores the effectiveness of Pokdarwis Kampoeng Djadhoel's management approach, which aligns seamlessly with the principles of tourism village management. Within the local community of RT 04 RW 02, participation is manifested both horizontally and vertically, significantly bolstering the overall management efforts. Crucially, the obstacles encountered within the Kampoeng Djadhoel tourist village have been successfully mitigated by harnessing supportive elements and implementing complementary solutions. This achievement exemplifies the village's commitment to sustainable innovations in promoting and developing its tourism potential, thereby addressing the challenges, and seizing the opportunities presented. Keywords: tourism management, tourism village, community participation, inhibiting and supporting factors, sustainable innovations
{"title":"Sustainable Innovations in the Promotion and Development of Village Tourism: Challenges and Opportunities","authors":"Ad Diena Islamy Haq, Tri Joko Raharjo","doi":"10.52403/ijrr.20231113","DOIUrl":"https://doi.org/10.52403/ijrr.20231113","url":null,"abstract":"Tourism serves as a catalyst for unlocking the unique potential and distinctiveness of specific regions, thereby fostering holistic well-being, particularly for the local economy. Kampoeng Djadhoel, situated in Semarang City's Rejomulyo Village, East Semarang District, is poised to fulfil this potential. Under the stewardship of an evolving Tourism Awareness Group (Pokdarwis), it aspires to transform into an enticing destination for both local and international visitors. To achieve this vision, it is essential to deepen our understanding of village management and actively engage the community. This study is a comprehensive exploration encompassing three critical domains: tourism village management, community participation, and identifying inhibiting and supporting factors. Employing a Descriptive Qualitative methodology, our investigation underscores the effectiveness of Pokdarwis Kampoeng Djadhoel's management approach, which aligns seamlessly with the principles of tourism village management. Within the local community of RT 04 RW 02, participation is manifested both horizontally and vertically, significantly bolstering the overall management efforts. Crucially, the obstacles encountered within the Kampoeng Djadhoel tourist village have been successfully mitigated by harnessing supportive elements and implementing complementary solutions. This achievement exemplifies the village's commitment to sustainable innovations in promoting and developing its tourism potential, thereby addressing the challenges, and seizing the opportunities presented. Keywords: tourism management, tourism village, community participation, inhibiting and supporting factors, sustainable innovations","PeriodicalId":13809,"journal":{"name":"International Journal of Current Research and Review","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135873084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Recent scientific findings indicate that hypertension is a largely genetically driven condition; one of today’s leading global health issues. There are many identified gene mutations associated with different aspects involving blood pressure control that lead to hypertension. More recently, certain specific genetic variants related to blood pressure control have been found using the modern techniques of genetic analysis that may assist in developing custom strategies to prevent and treat hypertension. The aim of this article is to highlight genetic aspects of hypertension and use them to establish individual therapy. It looks at the influence of genetic diversity on sodium resorption, skeletal muscle contraction, and drug pharmacokinetics. These studies indicate that GWAS has identified some genetic variants for hypertension and developed some genetic risk score (GRS) which can be used for prediction purpose. Therefore, genetic contribution is significant in establishing as well as sustaining high blood pressure. Knowledge about genetics regarding hypertension may change the way it is addressed on a person-by-person basis. Nevertheless, research needs to tackle the challenge of validating associations among diverse populations while developing a mechanism for translating genetic findings into clinical practice. Thus, we would enhance preventive, diagnostic and therapeutic measures for many people globally. Keywords: Hypertension; Genetic factors; Blood pressure regulation; Genome-wide association studies (GWAS); Personalized medicine approaches.
{"title":"Genetic Factors Associated with Hypertension: A Comprehensive Review","authors":"Ramakrishna Shabaraya A, Trupthi D Shetty","doi":"10.52403/ijrr.20231115","DOIUrl":"https://doi.org/10.52403/ijrr.20231115","url":null,"abstract":"Recent scientific findings indicate that hypertension is a largely genetically driven condition; one of today’s leading global health issues. There are many identified gene mutations associated with different aspects involving blood pressure control that lead to hypertension. More recently, certain specific genetic variants related to blood pressure control have been found using the modern techniques of genetic analysis that may assist in developing custom strategies to prevent and treat hypertension. The aim of this article is to highlight genetic aspects of hypertension and use them to establish individual therapy. It looks at the influence of genetic diversity on sodium resorption, skeletal muscle contraction, and drug pharmacokinetics. These studies indicate that GWAS has identified some genetic variants for hypertension and developed some genetic risk score (GRS) which can be used for prediction purpose. Therefore, genetic contribution is significant in establishing as well as sustaining high blood pressure. Knowledge about genetics regarding hypertension may change the way it is addressed on a person-by-person basis. Nevertheless, research needs to tackle the challenge of validating associations among diverse populations while developing a mechanism for translating genetic findings into clinical practice. Thus, we would enhance preventive, diagnostic and therapeutic measures for many people globally. Keywords: Hypertension; Genetic factors; Blood pressure regulation; Genome-wide association studies (GWAS); Personalized medicine approaches.","PeriodicalId":13809,"journal":{"name":"International Journal of Current Research and Review","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135873085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Deep Vein Thrombosis (DVT) is the formation of a thrombus in deep veins, often observed in stroke patients due to immobilization and infection during hospitalization. High D-dimer levels are associated with DVT in stroke patients. This study aims to evaluate the association between D-dimer levels as a diagnostic tool for DVT in acute ischemic stroke patients. Methods: This cross-sectional, retrospective study was conducted from May to August 2023. The study was carried out on acute ischemic stroke patients at Haji Adam Malik General Hospital, Medan, using consecutive sampling. Doppler ultrasound was used as the gold standard, and D-dimer data were analyzed using the SPSS program, employing the Chi-square test or Fisher's exact test. Results: Of the 49 patients, 35 met the inclusion criteria. Among the patients, 24 (68.6%) were male, 23 (65.7%) were over 50 years old, and 30 (85.7%) had a Body Mass Index (BMI) between 18-24.9. The mean D-dimer value was 2153.43 (±1506.88) ng/mL. All 21 (100%) DVT cases were asymptomatic. According to the Well's score, 15 patients scored 1 (42.8%), 20 patients (57.2%) scored 2, and the probability of DVT is in the moderate range for all 35 patients. The Fisher's Exact Test yielded a p-value of 0.028 (p<0.05). Conclusion: There is a significant relationship between D-dimer levels and the incidence of DVT in patients experiencing acute ischemic stroke. Keywords: Acute Ischemic Stroke, D-dimer, Deep Vein Thrombosis, Doppler Ultrasound
{"title":"The Relationship of D-dimer Levels and the Incident of Deep Vein Thrombosis in Acute Ischemic Stroke Patients at Haji Adam Malik General Hospital Medan","authors":"Daniel ., Dairion Gatot, Heny Syahrini Lubis","doi":"10.52403/ijrr.20231101","DOIUrl":"https://doi.org/10.52403/ijrr.20231101","url":null,"abstract":"Background: Deep Vein Thrombosis (DVT) is the formation of a thrombus in deep veins, often observed in stroke patients due to immobilization and infection during hospitalization. High D-dimer levels are associated with DVT in stroke patients. This study aims to evaluate the association between D-dimer levels as a diagnostic tool for DVT in acute ischemic stroke patients. Methods: This cross-sectional, retrospective study was conducted from May to August 2023. The study was carried out on acute ischemic stroke patients at Haji Adam Malik General Hospital, Medan, using consecutive sampling. Doppler ultrasound was used as the gold standard, and D-dimer data were analyzed using the SPSS program, employing the Chi-square test or Fisher's exact test. Results: Of the 49 patients, 35 met the inclusion criteria. Among the patients, 24 (68.6%) were male, 23 (65.7%) were over 50 years old, and 30 (85.7%) had a Body Mass Index (BMI) between 18-24.9. The mean D-dimer value was 2153.43 (±1506.88) ng/mL. All 21 (100%) DVT cases were asymptomatic. According to the Well's score, 15 patients scored 1 (42.8%), 20 patients (57.2%) scored 2, and the probability of DVT is in the moderate range for all 35 patients. The Fisher's Exact Test yielded a p-value of 0.028 (p<0.05). Conclusion: There is a significant relationship between D-dimer levels and the incidence of DVT in patients experiencing acute ischemic stroke. Keywords: Acute Ischemic Stroke, D-dimer, Deep Vein Thrombosis, Doppler Ultrasound","PeriodicalId":13809,"journal":{"name":"International Journal of Current Research and Review","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135873932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hyperglycaemia is a clinical indicator of Diabetes Mellitus (DM), chronic hyperglycemia in diabetes is associated with damage to organ systems, such as kidney damage, eyes, nerves, and blood vessels, and even death through oxidative stress processes, resulting in an imbalance between antioxidants and free radicals. One of the plants that contain antioxidants is Moringa Oleifera (MO), MO has been utilized as a food source material. This plant has low toxicity, natural antioxidants, and important bioactive phytochemicals and is an excellent source of alternative natural therapies to synthetic drugs. Exogenous antioxidants in Moringa leaves may have potential as free radical scavengers. Studies published between 2017 and 2023 were systematically reviewed through identification in Research Gate, Science Direct, PubMed, and Google Scholar databases. Studies that met the inclusion criteria were included for review. The results of the literature review of the articles carried out can be concluded that the administration of moringa leaf extract is able to reduce blood sugar levels, reduce MDA levels and increase antioxidants in the body, such as Superoxide Dismutase (SOD), Catalase (CAT) and Glutathione Peroxidase (GSH-Px). Keywords: Hyperglycaemia, Diabetes, Leaf Extract Moringa Oleifera, Oxidative Stress, Antioxidant
{"title":"Moringa Oleifera Leaf Extract as an Antioxidant on Malondialdehyde (MDA) and Glutathione Peroxidase (GSH-Px) Levels in Rats with Hyperglycemia: A Systematic Literature Review","authors":"Asti Marian, Eti Yerizel, Hudila Rif","doi":"10.52403/ijrr.20231104","DOIUrl":"https://doi.org/10.52403/ijrr.20231104","url":null,"abstract":"Hyperglycaemia is a clinical indicator of Diabetes Mellitus (DM), chronic hyperglycemia in diabetes is associated with damage to organ systems, such as kidney damage, eyes, nerves, and blood vessels, and even death through oxidative stress processes, resulting in an imbalance between antioxidants and free radicals. One of the plants that contain antioxidants is Moringa Oleifera (MO), MO has been utilized as a food source material. This plant has low toxicity, natural antioxidants, and important bioactive phytochemicals and is an excellent source of alternative natural therapies to synthetic drugs. Exogenous antioxidants in Moringa leaves may have potential as free radical scavengers. Studies published between 2017 and 2023 were systematically reviewed through identification in Research Gate, Science Direct, PubMed, and Google Scholar databases. Studies that met the inclusion criteria were included for review. The results of the literature review of the articles carried out can be concluded that the administration of moringa leaf extract is able to reduce blood sugar levels, reduce MDA levels and increase antioxidants in the body, such as Superoxide Dismutase (SOD), Catalase (CAT) and Glutathione Peroxidase (GSH-Px). Keywords: Hyperglycaemia, Diabetes, Leaf Extract Moringa Oleifera, Oxidative Stress, Antioxidant","PeriodicalId":13809,"journal":{"name":"International Journal of Current Research and Review","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135873560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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