Pub Date : 2021-02-27DOI: 10.7897/2230-8407.1202121
Nirmala R Kakade, Vikas M Jagdale, Ganesh R Jiwade
The comparative phytochemical analysis of leaves, stem and fruit powder of Tribulus terrestris was carried out by using preliminary phytochemical screening. To identify the phytochemical constituents, present in water and ethanol extracts of Tribulus terrestris leaves, stem and fruit, a preliminary analysis was done by using different testing methods of Frothing test, Mayer’s test, Hager’s test, Foam formation test, Lead acetate test, Molisch’s test and Ferric Chloride test. The phytochemical analysis study showed the presence of 3.903%, 1.725% and 2.259% terpenoids & phenolic in leaves, stem and fruit parts of Tribulus terrestris respectively. The study showed the presence of 16.574%, 15.943% and 10.168% alkaloids and 0.240%, 0.160% and 0.230% Q. alkaloid & N-oxides in leaves stem and fruit extracts respectively. 2.888%, 0.825% and 2.679% fats and waxes and 76.395%, 81.347% and 84.672% fibers were observed in leaves, stem and fruit extracts of this plant respectively
{"title":"PHYTOCHEMICAL SCREENING OF LEAVES, STEM AND FRUIT PARTS OF TRIBULUS TERRESTRIS","authors":"Nirmala R Kakade, Vikas M Jagdale, Ganesh R Jiwade","doi":"10.7897/2230-8407.1202121","DOIUrl":"https://doi.org/10.7897/2230-8407.1202121","url":null,"abstract":"The comparative phytochemical analysis of leaves, stem and fruit powder of Tribulus terrestris was carried out by using preliminary phytochemical screening. To identify the phytochemical constituents, present in water and ethanol extracts of Tribulus terrestris leaves, stem and fruit, a preliminary analysis was done by using different testing methods of Frothing test, Mayer’s test, Hager’s test, Foam formation test, Lead acetate test, Molisch’s test and Ferric Chloride test. The phytochemical analysis study showed the presence of 3.903%, 1.725% and 2.259% terpenoids & phenolic in leaves, stem and fruit parts of Tribulus terrestris respectively. The study showed the presence of 16.574%, 15.943% and 10.168% alkaloids and 0.240%, 0.160% and 0.230% Q. alkaloid & N-oxides in leaves stem and fruit extracts respectively. 2.888%, 0.825% and 2.679% fats and waxes and 76.395%, 81.347% and 84.672% fibers were observed in leaves, stem and fruit extracts of this plant respectively","PeriodicalId":14413,"journal":{"name":"International Research Journal Of Pharmacy","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91111747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-02-27DOI: 10.7897/2230-8407.1202122
Aman D. Sharma, A. Agarwal
The objective of the current study is to improve the patient compliance and sustained drug release action by herbal medicine which can be achieved by developing alternative drug delivery system. The matrix type transdermal patches containing plumbagin were prepared by solvent evaporation method with different ratios of polymers (HPMC 50cps, PVP K29-32 and EUDRAGIT RS-100). In these matrix type transdermal patches, the PEG (Polyethylene glycol) was used as plasticizer and DMSO (Dimethyl sulfoxide) used as a penetration enhancer. The formulated patches were evaluated for physicochemical parameters like thickness, weight variation, % moisture content, % moisture uptake, % flatness, folding endurance and drug content. In vitro drug release studies were carried out by using the Franz diffusion cell. The cumulative % of drug released in 10 hours from the six batch formulations were 95.66%, 94.2%, 97.33%, 90.13%, 83.75% and 85.71%, respectively. On the basis of in-vitro drug release, formulation (HE-2) was found to be better than other formulation and these were selected for further evaluation such as anti-fungal activity and stability studies.
{"title":"FORMULATION AND EVALUATION OF TRANSDERMAL PATCH OF PLUMBAGIN FOR ANTI-FUNGAL ACTIVITIES","authors":"Aman D. Sharma, A. Agarwal","doi":"10.7897/2230-8407.1202122","DOIUrl":"https://doi.org/10.7897/2230-8407.1202122","url":null,"abstract":"The objective of the current study is to improve the patient compliance and sustained drug release action by herbal medicine which can be achieved by developing alternative drug delivery system. The matrix type transdermal patches containing plumbagin were prepared by solvent evaporation method with different ratios of polymers (HPMC 50cps, PVP K29-32 and EUDRAGIT RS-100). In these matrix type transdermal patches, the PEG (Polyethylene glycol) was used as plasticizer and DMSO (Dimethyl sulfoxide) used as a penetration enhancer. The formulated patches were evaluated for physicochemical parameters like thickness, weight variation, % moisture content, % moisture uptake, % flatness, folding endurance and drug content. In vitro drug release studies were carried out by using the Franz diffusion cell. The cumulative % of drug released in 10 hours from the six batch formulations were 95.66%, 94.2%, 97.33%, 90.13%, 83.75% and 85.71%, respectively. On the basis of in-vitro drug release, formulation (HE-2) was found to be better than other formulation and these were selected for further evaluation such as anti-fungal activity and stability studies.","PeriodicalId":14413,"journal":{"name":"International Research Journal Of Pharmacy","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85157680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-02-27DOI: 10.7897/2230-8407.1202120
V. Manivasagan, K. Susmitha, S. Prabavathi, K. Saranya, N. Babu
The present study aims to evaluate the potential of agro wastes such as apple pomace, Grasses, sugarcane bagasse as potential sources of bioethanol production. Bioethanol is the one of the recent increasing biofuels due to its positive impact on the environment and especially towards second generation of biofuels i.e. from non-food biomass. It’s produced from high sugar and starch containing raw materials and lignocellulosic biomass. Lignocellulose may be a complex mixture of carbohydrate that needs an efficient pretreatment for the assembly of fermentable sugar, after hydrolysis are fermented into ethanol. Pretreatment of lignocellulose has received considerable research globally thanks to economic and environmental sustainability of ethanol production. Microbes like Zymomonas mobilis, and Phanerochaete provide sufficient fermentation yield and can be utilized for fermenting lignocellulosic substrate. These microbes are isolated from the feedstock samples in the present study. A suitable media was also designed for the growth of the isolated microorganisms. The antioxidant tests were analyzed on the potential samples using UV-VIS spectrophotometer. Lowering the cost of bioethanol production is one of the biggest challenges currently and can be greatly reduced by utilizing renewable feedstocks. Thus, making bioethanol is more economically competitive compared to fossil fuel.
{"title":"ANTIOXIDANT ACTIVITY OF PHENOLIC COMPOUNDS AS BYPRODUCT OF BIOETHANOL PRODUCTION FROM AGRO-WASTES","authors":"V. Manivasagan, K. Susmitha, S. Prabavathi, K. Saranya, N. Babu","doi":"10.7897/2230-8407.1202120","DOIUrl":"https://doi.org/10.7897/2230-8407.1202120","url":null,"abstract":"The present study aims to evaluate the potential of agro wastes such as apple pomace, Grasses, sugarcane bagasse as potential sources of bioethanol production. Bioethanol is the one of the recent increasing biofuels due to its positive impact on the environment and especially towards second generation of biofuels i.e. from non-food biomass. It’s produced from high sugar and starch containing raw materials and lignocellulosic biomass. Lignocellulose may be a complex mixture of carbohydrate that needs an efficient pretreatment for the assembly of fermentable sugar, after hydrolysis are fermented into ethanol. Pretreatment of lignocellulose has received considerable research globally thanks to economic and environmental sustainability of ethanol production. Microbes like Zymomonas mobilis, and Phanerochaete provide sufficient fermentation yield and can be utilized for fermenting lignocellulosic substrate. These microbes are isolated from the feedstock samples in the present study. A suitable media was also designed for the growth of the isolated microorganisms. The antioxidant tests were analyzed on the potential samples using UV-VIS spectrophotometer. Lowering the cost of bioethanol production is one of the biggest challenges currently and can be greatly reduced by utilizing renewable feedstocks. Thus, making bioethanol is more economically competitive compared to fossil fuel.","PeriodicalId":14413,"journal":{"name":"International Research Journal Of Pharmacy","volume":"102 1","pages":"11-18"},"PeriodicalIF":0.0,"publicationDate":"2021-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79390576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-02-27DOI: 10.7897/2230-8407.1202119
Deena Al-Samman, Mohammed Attar Bashi
Objectives: To highlight the knowledge, frequency, types, and the clinical aspects of overusing TCs on the face as well as the motivation for such practice, with the aim of rising the public awareness in Mosul City. Methods: This prospective observational study included 180 patients aged 13-53 years, with steroid dermatitis resembling rosacea "Iatrosacea" with history of using TCs on face > 1 month, were evaluated at Al-Qudis Health Center for Family Medicine. Patients contradicted using TCs, or with classical rosacea were excluded. Results: The majority were females (90%). Duration was 2 months to 7 years. The motives were fairness (55%) and melasma (19%). The commonly abused drug was Betamethasone Valerate (35%). The reported side effects were facial erythema (84%), telangiectasia (79%), rebound phenomenon (66%), rosacea (56%), and acne (42%). The exacerbation on stopping TCs (63%) and skin lightening (37%) were the main reasons behind continued use; 59% were unaware about side effects of TCs; 42% obtained the products from cosmetic shop/Beautician and 27% from nurse clinic. In spite of observable side effects, 74% of abusers didn't feel guilty for applying them for protracted periods. Conclusion: Inappropriate use of TCs for cosmetic purposes is still commonly encountered in our environment, with believe TCs will correct any facial imperfection. As fair skin is correlated with beauty and social privilege, both genders of different ages, social, and educational status are indulged in this practice that exposed them to medical and social problems. It is a multiphase issue necessitates collaboration of different sectors to raise public awareness and control their easy availability to overcome this dilemma.
{"title":"IATROSACEA FOLLOWING ABUSE OF TOPICAL STEROIDS AS A FACE-WHITENING CREAM IN MOSUL CITY","authors":"Deena Al-Samman, Mohammed Attar Bashi","doi":"10.7897/2230-8407.1202119","DOIUrl":"https://doi.org/10.7897/2230-8407.1202119","url":null,"abstract":"Objectives: To highlight the knowledge, frequency, types, and the clinical aspects of overusing TCs on the face as well as the motivation for such practice, with the aim of rising the public awareness in Mosul City. Methods: This prospective observational study included 180 patients aged 13-53 years, with steroid dermatitis resembling rosacea \"Iatrosacea\" with history of using TCs on face > 1 month, were evaluated at Al-Qudis Health Center for Family Medicine. Patients contradicted using TCs, or with classical rosacea were excluded. Results: The majority were females (90%). Duration was 2 months to 7 years. The motives were fairness (55%) and melasma (19%). The commonly abused drug was Betamethasone Valerate (35%). The reported side effects were facial erythema (84%), telangiectasia (79%), rebound phenomenon (66%), rosacea (56%), and acne (42%). The exacerbation on stopping TCs (63%) and skin lightening (37%) were the main reasons behind continued use; 59% were unaware about side effects of TCs; 42% obtained the products from cosmetic shop/Beautician and 27% from nurse clinic. In spite of observable side effects, 74% of abusers didn't feel guilty for applying them for protracted periods. Conclusion: Inappropriate use of TCs for cosmetic purposes is still commonly encountered in our environment, with believe TCs will correct any facial imperfection. As fair skin is correlated with beauty and social privilege, both genders of different ages, social, and educational status are indulged in this practice that exposed them to medical and social problems. It is a multiphase issue necessitates collaboration of different sectors to raise public awareness and control their easy availability to overcome this dilemma.","PeriodicalId":14413,"journal":{"name":"International Research Journal Of Pharmacy","volume":"30 1","pages":"5-10"},"PeriodicalIF":0.0,"publicationDate":"2021-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89017611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-02-27DOI: 10.7897/2230-8407.1202118
Syeda Jabeen Unnisa, Swarupa Arvapalli, B. Karunakar, PS Reddy, A. Vaishnavi, J. Sharma
Transdermal administration of drug is generally limited by the barrier function of the skin vascular system are one of the most controversial method for transdermal delivery of active substance. transdermal drug delivery system is designed to deliver biological active agents through the skin, principally by diffusion for local internal if not systemic effects. The transdermal delivery system was relaunched after the discovery of elastic vesicles like transfersome, ethosome, cubosome, phytosome etc. Transfersomes are a form of elastic or deformable vesicle, which were introduced in the early 1990s. Elasticity is generated by incorporation of edge activator in lipid bilayer structure. Drug absorbed and distributed into organs and tissue and eliminated from the body it must pass through one or more biological membranes at various locations such movement of drug across the membrane is called as drug transport for the drug delivery to cross the body it should pass through the membrane barrier. This concept of drug delivery system was designed in attempt to concentrate the amount of drug in the remaining drug; therefore, the phospholipid-based carrier system is of considerable interest in the era.
{"title":"A NARRATIVE REVIEW ON TRANSFERSOMES: VESICULAR TRANSDERMAL DELIVERY SYSTEM FOR ENHANCED DRUG PERMEATION","authors":"Syeda Jabeen Unnisa, Swarupa Arvapalli, B. Karunakar, PS Reddy, A. Vaishnavi, J. Sharma","doi":"10.7897/2230-8407.1202118","DOIUrl":"https://doi.org/10.7897/2230-8407.1202118","url":null,"abstract":"Transdermal administration of drug is generally limited by the barrier function of the skin vascular system are one of the most controversial method for transdermal delivery of active substance. transdermal drug delivery system is designed to deliver biological active agents through the skin, principally by diffusion for local internal if not systemic effects. The transdermal delivery system was relaunched after the discovery of elastic vesicles like transfersome, ethosome, cubosome, phytosome etc. Transfersomes are a form of elastic or deformable vesicle, which were introduced in the early 1990s. Elasticity is generated by incorporation of edge activator in lipid bilayer structure. Drug absorbed and distributed into organs and tissue and eliminated from the body it must pass through one or more biological membranes at various locations such movement of drug across the membrane is called as drug transport for the drug delivery to cross the body it should pass through the membrane barrier. This concept of drug delivery system was designed in attempt to concentrate the amount of drug in the remaining drug; therefore, the phospholipid-based carrier system is of considerable interest in the era.","PeriodicalId":14413,"journal":{"name":"International Research Journal Of Pharmacy","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89889967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-31DOI: 10.7897/2230-8407.1201112
Henni Rosaini, Auzal Halim, Ica Elpitha Sandi, I. Makmur, Ridho Asra, Wahyu Margi Sidoretno
Kepok banana peel (Musa x paradisiaca L.) contains flavonoids that act as antioxidants. The antioxidant activity of the ethanol extract of Kepok banana peel can be used as an active ingredient of nano gel. Nano-sized preparations can increase the efficiency of the delivery of active ingredients with lesser side effects and also decrease the stratum corneum to make it easier to penetrate. The objectives of this study were to determine whether the ethanol extract of Kepok banana peel (Musa x paradisiaca L.) can be formulated as nano gel and to measure its antioxidant activity. The method of nano gel preparation was stirring technique by using a magnetic stirrer and a sonicator. The antioxidant activity was measured using DPPH method. The results showed that the ethanol extract of kepok banana peel could be formulated as nano gel with size F0 = 161.9 nm; F1 = 171.3 nm; F2 = 165.6 nm; F3 = 163.9 nm which fulfilled the nano gel size requirement (20-200 nm) and the potential zeta value F0 = -43.4 mV; F1 = -43.7 mV; F2 = -46.9 mV; F3 = -47.0 mV fulfilled the requirements (smaller than -30 mV and greater than +30 mV). The antioxidant activity showed that the IC50 of ethanol extract of was stronger than IC50 of 1% nano gel (198.0279 µg/ml : 282.8933 µg/ml).
{"title":"FORMULATION AND ANTIOXIDANT ACTIVITY OF NANO GEL ETHANOL EXTRACT OF KEPOK BANANA PEEL (MUSA X PARADISIACA L.)","authors":"Henni Rosaini, Auzal Halim, Ica Elpitha Sandi, I. Makmur, Ridho Asra, Wahyu Margi Sidoretno","doi":"10.7897/2230-8407.1201112","DOIUrl":"https://doi.org/10.7897/2230-8407.1201112","url":null,"abstract":"Kepok banana peel (Musa x paradisiaca L.) contains flavonoids that act as antioxidants. The antioxidant activity of the ethanol extract of Kepok banana peel can be used as an active ingredient of nano gel. Nano-sized preparations can increase the efficiency of the delivery of active ingredients with lesser side effects and also decrease the stratum corneum to make it easier to penetrate. The objectives of this study were to determine whether the ethanol extract of Kepok banana peel (Musa x paradisiaca L.) can be formulated as nano gel and to measure its antioxidant activity. The method of nano gel preparation was stirring technique by using a magnetic stirrer and a sonicator. The antioxidant activity was measured using DPPH method. The results showed that the ethanol extract of kepok banana peel could be formulated as nano gel with size F0 = 161.9 nm; F1 = 171.3 nm; F2 = 165.6 nm; F3 = 163.9 nm which fulfilled the nano gel size requirement (20-200 nm) and the potential zeta value F0 = -43.4 mV; F1 = -43.7 mV; F2 = -46.9 mV; F3 = -47.0 mV fulfilled the requirements (smaller than -30 mV and greater than +30 mV). The antioxidant activity showed that the IC50 of ethanol extract of was stronger than IC50 of 1% nano gel (198.0279 µg/ml : 282.8933 µg/ml).","PeriodicalId":14413,"journal":{"name":"International Research Journal Of Pharmacy","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74892598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hypertension is one of the most common causes of morbidity and premature death worldwide. Hypertension or high blood pressure is a condition of an increase in systolic blood pressure ≥140 mmHg and diastolic blood pressure ≥90 mmHg. Hypertension is very dangerous because in most cases there are no symptoms in the sufferer (silent killer). Conventional treatment for hypertension often causes various side effects, so that the choice of herbal treatment is being considered more. Medicinal plants such as Cratoxylum formosum, Adansonia digitata L., Vitex pubescens, Cinnamomum zeylanicum, Catharanthus roseus, Crotalaria burhia, Leersia hexandra, Moringa oleifera L., Allanblackia floribunda, Holarrhena floribunda, Berberis vulgaris, Morinda citrifolia L., Ficus carica, Bidens pilosa, Panax ginseng, Lantana camara, Allium sativum, Apium graveolens, Vitex cienkowskii, and Achillea wilhelmsii have antihypertensive activity which can be used as an alternative in the treatment and prevention of hypertension. This review article used the literature study method of national and international journals published in the last 10 years (2010-2020) that was done through several websites such as ScienceDirect, NCBI, ResearchGate and Google Scholar.
{"title":"PLANTS WITH ANTIHYPERTENSIVE ACTIVITIES: A REVIEW","authors":"Indah Irma Suryani Lubis, Zikra Azizah, Rusdi, Ridho Asra","doi":"10.7897/2230-8407.1201117","DOIUrl":"https://doi.org/10.7897/2230-8407.1201117","url":null,"abstract":"Hypertension is one of the most common causes of morbidity and premature death worldwide. Hypertension or high blood pressure is a condition of an increase in systolic blood pressure ≥140 mmHg and diastolic blood pressure ≥90 mmHg. Hypertension is very dangerous because in most cases there are no symptoms in the sufferer (silent killer). Conventional treatment for hypertension often causes various side effects, so that the choice of herbal treatment is being considered more. Medicinal plants such as Cratoxylum formosum, Adansonia digitata L., Vitex pubescens, Cinnamomum zeylanicum, Catharanthus roseus, Crotalaria burhia, Leersia hexandra, Moringa oleifera L., Allanblackia floribunda, Holarrhena floribunda, Berberis vulgaris, Morinda citrifolia L., Ficus carica, Bidens pilosa, Panax ginseng, Lantana camara, Allium sativum, Apium graveolens, Vitex cienkowskii, and Achillea wilhelmsii have antihypertensive activity which can be used as an alternative in the treatment and prevention of hypertension. This review article used the literature study method of national and international journals published in the last 10 years (2010-2020) that was done through several websites such as ScienceDirect, NCBI, ResearchGate and Google Scholar.","PeriodicalId":14413,"journal":{"name":"International Research Journal Of Pharmacy","volume":"58 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89466268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-31DOI: 10.7897/2230-8407.1201115
A. Tripathi, Suraj Neupane, K. Bhardwaj, Shivakaht Mishra, Meenakshi Gupta, R. K. Mishra
The purpose of the present work is to prolong the gastric residence time of Lornoxicam by developing gastric floating drug delivery system. Lornoxicam is non-steroidal anti-inflammatory drugs. Its short half life 2 to 3 hrs and maximal absorption of upper part of gastrointestinal tract. The residence time of the dosage form in the stomach depends upon various factors like pH, size of the dosage form, food intake, and biological factors which include age, body weight gender, posture, and diseased states Floating tablet prepared by melt granulation techniques, using bees wax as a binder and the other polymers include HPMC 50cPs,15cPs,5cPs and Sodium Alginate. The Prepared granules were then evaluated for Precompression Properties. The best batches were then tabulated, and Evaluation was carried out for the following parameters with in vitro release, buoyancy, Floating Lag timed. Batch F12 and F13 Showed best Floating time of 12hrs and Floating Lag time of 60 second.
{"title":"FLOATING DRUG DELIVERY SYSTEM OF NSAIDS TO INCREASE GASTRIC RETENTION TIME IN UPPER PART OF GASTROINTESTINAL TRACT","authors":"A. Tripathi, Suraj Neupane, K. Bhardwaj, Shivakaht Mishra, Meenakshi Gupta, R. K. Mishra","doi":"10.7897/2230-8407.1201115","DOIUrl":"https://doi.org/10.7897/2230-8407.1201115","url":null,"abstract":"The purpose of the present work is to prolong the gastric residence time of Lornoxicam by developing gastric floating drug delivery system. Lornoxicam is non-steroidal anti-inflammatory drugs. Its short half life 2 to 3 hrs and maximal absorption of upper part of gastrointestinal tract. The residence time of the dosage form in the stomach depends upon various factors like pH, size of the dosage form, food intake, and biological factors which include age, body weight gender, posture, and diseased states Floating tablet prepared by melt granulation techniques, using bees wax as a binder and the other polymers include HPMC 50cPs,15cPs,5cPs and Sodium Alginate. The Prepared granules were then evaluated for Precompression Properties. The best batches were then tabulated, and Evaluation was carried out for the following parameters with in vitro release, buoyancy, Floating Lag timed. Batch F12 and F13 Showed best Floating time of 12hrs and Floating Lag time of 60 second.","PeriodicalId":14413,"journal":{"name":"International Research Journal Of Pharmacy","volume":"43 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84421831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-31DOI: 10.7897/2230-8407.1201114
P. Aravanan, S. Jayakumari
Of all types of plants, we come across everyday every plant is useful some more than other. Our predecessors left an ocean of knowledge regarding the usage of natural sources for medicinal purposes all that we need is, to work on the molecular level to better understand how to avoid negative effects. In the present study Chloroform and Ethanolic extracts of Bauhinia racemosa obtained by soxhlation were used in the determination of Hepatoprotective activity using Paracetamol induced hepatotoxicity method. Oral administration of Bauhinia racemosa Chloroform extract and Bauhinia racemosa Ethanolic Extract showed significant decrease in biochemical parameters such as the ALT, AST, ALP. Animals treated with Ethanolic extract at dose level of 200 mg/kg & 400 mg/kg b.w, p.o in Hepatotoxicity induced rats exhibited a significant reduction of ALP (178.2±1.65 & 169.1±1.88), AST (123.5±1.87 & 115.7±1.25), ALT (115.2±0.94 & 111.4±1.29) respectively. Extensive literature review showed that Bauhinia racemosa is capable of several pharmacological activities and the present study sheds light on the hepatoprotective nature of the selected plant.
{"title":"HEPATOPROTECTIVE ACTIVITY OF BAUHINIA RACEMOSA ROOTS EXTRACTS","authors":"P. Aravanan, S. Jayakumari","doi":"10.7897/2230-8407.1201114","DOIUrl":"https://doi.org/10.7897/2230-8407.1201114","url":null,"abstract":"Of all types of plants, we come across everyday every plant is useful some more than other. Our predecessors left an ocean of knowledge regarding the usage of natural sources for medicinal purposes all that we need is, to work on the molecular level to better understand how to avoid negative effects. In the present study Chloroform and Ethanolic extracts of Bauhinia racemosa obtained by soxhlation were used in the determination of Hepatoprotective activity using Paracetamol induced hepatotoxicity method. Oral administration of Bauhinia racemosa Chloroform extract and Bauhinia racemosa Ethanolic Extract showed significant decrease in biochemical parameters such as the ALT, AST, ALP. Animals treated with Ethanolic extract at dose level of 200 mg/kg & 400 mg/kg b.w, p.o in Hepatotoxicity induced rats exhibited a significant reduction of ALP (178.2±1.65 & 169.1±1.88), AST (123.5±1.87 & 115.7±1.25), ALT (115.2±0.94 & 111.4±1.29) respectively. Extensive literature review showed that Bauhinia racemosa is capable of several pharmacological activities and the present study sheds light on the hepatoprotective nature of the selected plant.","PeriodicalId":14413,"journal":{"name":"International Research Journal Of Pharmacy","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83128550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-31DOI: 10.7897/2230-8407.1201111
A. Tripathi, Sapna Chaudhar, K. Bhardwaj, Lalit Rana, V. Chauhan, Radhika Chaurasia
Floating drug delivery system was to organize the recent journalism with unique focus on the principal mechanism of floatation to achieve gastric retention. The recent developments of FDDS including the physiological and formulation variables affecting gastric retention, approaches to design single unit and multiple unit floating systems. In the recent decades, there have been numerous attempts to overcome the barrier like short gastric residence times and unpredictable gastric emptying times. This review also summarizes the in –vitro technique of evaluation, all the pre-formulation and post formulation evaluations criteria. These systems are useful to several problems encountered during the development of pharmaceutical dosage form. In this review, the technologies of formulation and mechanism of drug release, advantage, application in drug delivery of floating systems are discussed.
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