Pub Date : 2020-04-07DOI: 10.1080/09506608.2020.1750807
M. Ashokkumar, P. Ajayan
ABSTRACT Grand challenges facing humanity today are closely linked to the rapid exhaustion of natural resources in conjunction with the massive growth of industrial production that sustains the booming world population. The processing of animal skin waste to create collagen-based materials has the potential to provide an eco-friendly method to develop multifunctional materials such as films, sponges/scaffolds, fibers, gels, etc., that could contribute to technological advancements in different sectors. Hence in this review, we present methods for potential improvements in the development of collagen-based materials from a materials science perspective. We explored different possible approaches for utilizing collagen to generate multifunctional materials that exhibit outstanding properties, in combination with mechanical robustness and chemical stability. In sum, this review will present collagen as an eco-friendly resource that can be used to produce multifunctional, recyclable, biocompatible, and biodegradable materials that are ideal for new technologies in materials science, biomedicine, and environmental remediation.
{"title":"Materials science perspective of multifunctional materials derived from collagen","authors":"M. Ashokkumar, P. Ajayan","doi":"10.1080/09506608.2020.1750807","DOIUrl":"https://doi.org/10.1080/09506608.2020.1750807","url":null,"abstract":"ABSTRACT Grand challenges facing humanity today are closely linked to the rapid exhaustion of natural resources in conjunction with the massive growth of industrial production that sustains the booming world population. The processing of animal skin waste to create collagen-based materials has the potential to provide an eco-friendly method to develop multifunctional materials such as films, sponges/scaffolds, fibers, gels, etc., that could contribute to technological advancements in different sectors. Hence in this review, we present methods for potential improvements in the development of collagen-based materials from a materials science perspective. We explored different possible approaches for utilizing collagen to generate multifunctional materials that exhibit outstanding properties, in combination with mechanical robustness and chemical stability. In sum, this review will present collagen as an eco-friendly resource that can be used to produce multifunctional, recyclable, biocompatible, and biodegradable materials that are ideal for new technologies in materials science, biomedicine, and environmental remediation.","PeriodicalId":14427,"journal":{"name":"International Materials Reviews","volume":"66 1","pages":"160 - 187"},"PeriodicalIF":16.1,"publicationDate":"2020-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/09506608.2020.1750807","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42614497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-04-02DOI: 10.1080/09506608.2019.1582180
Yao Huang, Christopher Ellingford, C. Bowen, T. McNally, Daming Wu, C. Wan
ABSTRACT The majority of polymers are electrical and thermal insulators. In order to create electrically active and thermally conductive polymers and composites, the hybrid-filler systems is an effective approach, i.e. combining different types of fillers with different dimensions, in order to facilitate the formation of interconnected conducting networks and to enhance the electrical, thermal, mechanical and processing properties synergistically. By tailoring polymer-filler interactions both thermodynamically and kinetically, the selective localisation of fillers in polymer blends and at the interface of co-continuous polymer blends can enhance the electrical conductivity at a low percolation threshold. Moreover, selective localisation of different filler types in different co-continuous phases can result in multiple functionalities, such as high electrical conductivity, thermal conductivity or electromagnetic interference shielding. In this review, we discuss the latest progress towards the development of electrically active and thermally conductive polymer composites, and highlight the technical challenges and future research directions.
{"title":"Tailoring the electrical and thermal conductivity of multi-component and multi-phase polymer composites","authors":"Yao Huang, Christopher Ellingford, C. Bowen, T. McNally, Daming Wu, C. Wan","doi":"10.1080/09506608.2019.1582180","DOIUrl":"https://doi.org/10.1080/09506608.2019.1582180","url":null,"abstract":"ABSTRACT The majority of polymers are electrical and thermal insulators. In order to create electrically active and thermally conductive polymers and composites, the hybrid-filler systems is an effective approach, i.e. combining different types of fillers with different dimensions, in order to facilitate the formation of interconnected conducting networks and to enhance the electrical, thermal, mechanical and processing properties synergistically. By tailoring polymer-filler interactions both thermodynamically and kinetically, the selective localisation of fillers in polymer blends and at the interface of co-continuous polymer blends can enhance the electrical conductivity at a low percolation threshold. Moreover, selective localisation of different filler types in different co-continuous phases can result in multiple functionalities, such as high electrical conductivity, thermal conductivity or electromagnetic interference shielding. In this review, we discuss the latest progress towards the development of electrically active and thermally conductive polymer composites, and highlight the technical challenges and future research directions.","PeriodicalId":14427,"journal":{"name":"International Materials Reviews","volume":"65 1","pages":"129 - 163"},"PeriodicalIF":16.1,"publicationDate":"2020-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/09506608.2019.1582180","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45456233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-25DOI: 10.1080/09506608.2020.1743592
Priyatham Tumurugoti, S. Betal, S. K. Sundaram
ABSTRACT This review provides a broad overview of the structural characteristics, compositional flexibility, and structure–property relationships of hollandite materials. Hollandites have a general formula AxB 8O16, x ≤ 2, with ‘A’ cations located in one-dimensional tunnels formed by a framework of ‘B’–O octahedra. With numerous possibilities for chemical and structural modifications, hollandite family provides many opportunities to manipulate its properties for specific applications. First, we review the chemistry, structure–property relationship, and processing techniques for various applications. The primary focus is on the cumulative effects of A- and B-cation interaction, and the resultant parameters including unit cell symmetry, cation order–disorder, electronic and/or magnetic coupling, that dictate the material's applicability. Then, selected applications, such as crystalline hosts for radioactive caesium disposal, electrode material for Li-ion batteries, and ferromagnetic materials, are outlined from a structure–property relationship perspective. Finally, processing strategies in correlation with structural evolution and applications are briefly addressed.
本文综述了荷兰石材料的结构特点、组成柔韧性和结构-性能关系。荷兰人有一个通式AxB 8O16, x≤2，其中' a '阳离子位于由' B ' -O八面体框架形成的一维隧道中。由于有许多化学和结构修饰的可能性，荷兰石家族为特定应用提供了许多操纵其性质的机会。首先，我们综述了其化学性质、结构-性能关系以及各种应用的加工技术。主要关注的是A-和b -阳离子相互作用的累积效应，以及由此产生的参数，包括单位细胞对称性、阳离子有序无序、电子和/或磁耦合，这些参数决定了材料的适用性。然后，从结构-性能关系的角度概述了一些选定的应用，如用于放射性铯处置的晶体宿主，锂离子电池的电极材料和铁磁性材料。最后，简要介绍了与结构演变和应用相关的加工策略。
{"title":"Hollandites’ crystal chemistry, properties, and processing: a review","authors":"Priyatham Tumurugoti, S. Betal, S. K. Sundaram","doi":"10.1080/09506608.2020.1743592","DOIUrl":"https://doi.org/10.1080/09506608.2020.1743592","url":null,"abstract":"ABSTRACT This review provides a broad overview of the structural characteristics, compositional flexibility, and structure–property relationships of hollandite materials. Hollandites have a general formula AxB 8O16, x ≤ 2, with ‘A’ cations located in one-dimensional tunnels formed by a framework of ‘B’–O octahedra. With numerous possibilities for chemical and structural modifications, hollandite family provides many opportunities to manipulate its properties for specific applications. First, we review the chemistry, structure–property relationship, and processing techniques for various applications. The primary focus is on the cumulative effects of A- and B-cation interaction, and the resultant parameters including unit cell symmetry, cation order–disorder, electronic and/or magnetic coupling, that dictate the material's applicability. Then, selected applications, such as crystalline hosts for radioactive caesium disposal, electrode material for Li-ion batteries, and ferromagnetic materials, are outlined from a structure–property relationship perspective. Finally, processing strategies in correlation with structural evolution and applications are briefly addressed.","PeriodicalId":14427,"journal":{"name":"International Materials Reviews","volume":"66 1","pages":"141 - 159"},"PeriodicalIF":16.1,"publicationDate":"2020-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/09506608.2020.1743592","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45000630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-18DOI: 10.1080/09506608.2020.1735117
W. Park, Kwang Hoon Song, Jaesung Lim, Chun Gwon Park, Junsang Doh, D. Han
ABSTRACT Cancer immunotherapy has been extremely successful in curing patients over the last decade. Immune checkpoint blockades (ICBs) that unleash the brakes in T-cells to promote cytotoxicity against cancer cells are the most successful forms of cancer immunotherapy, yet therapeutic efficacy needs to be improved as only a fraction of patients responds. Dendritic cells (DCs) are immune cells that prime immune responses by collecting information in tumour tissues, and carrying that information to T-cells, thus delivering proper information to DCs is essential. Biomaterial-based approaches can be powerful tools for this purpose, as biomaterials allow us to deliver a variety of immunotherapeutic agents at the right time and place. Herein, we review the key concepts of cancer immunotherapy; discuss the principles for designing biomaterials to deliver immunomodulatory molecules; and outline biomaterial-based strategies to prime anti-cancer immune responses. Specifically, we focus on two widely used forms of biomaterials, multifunctional nanoparticles and biocompatible scaffolds.
{"title":"Biomaterial-based strategies to prime dendritic cell-mediated anti-cancer immune responses","authors":"W. Park, Kwang Hoon Song, Jaesung Lim, Chun Gwon Park, Junsang Doh, D. Han","doi":"10.1080/09506608.2020.1735117","DOIUrl":"https://doi.org/10.1080/09506608.2020.1735117","url":null,"abstract":"ABSTRACT Cancer immunotherapy has been extremely successful in curing patients over the last decade. Immune checkpoint blockades (ICBs) that unleash the brakes in T-cells to promote cytotoxicity against cancer cells are the most successful forms of cancer immunotherapy, yet therapeutic efficacy needs to be improved as only a fraction of patients responds. Dendritic cells (DCs) are immune cells that prime immune responses by collecting information in tumour tissues, and carrying that information to T-cells, thus delivering proper information to DCs is essential. Biomaterial-based approaches can be powerful tools for this purpose, as biomaterials allow us to deliver a variety of immunotherapeutic agents at the right time and place. Herein, we review the key concepts of cancer immunotherapy; discuss the principles for designing biomaterials to deliver immunomodulatory molecules; and outline biomaterial-based strategies to prime anti-cancer immune responses. Specifically, we focus on two widely used forms of biomaterials, multifunctional nanoparticles and biocompatible scaffolds.","PeriodicalId":14427,"journal":{"name":"International Materials Reviews","volume":"65 1","pages":"445 - 462"},"PeriodicalIF":16.1,"publicationDate":"2020-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/09506608.2020.1735117","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42086023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-18DOI: 10.1080/09506608.2020.1735828
Gabriele Griffanti, S. Nazhat
ABSTRACT There is an increasing need to generate novel materials for the treatment and augmentation of bone defects, affecting millions of people worldwide. Fibrillar type I collagen is the most abundant tissue matrix protein in bone, providing its key native scaffolding material. However, while in vitro reconstituted collagen hydrogels of physically entangled, nano-fibred meshes, have long served as three-dimensional cultures, their highly-hydrated nature impacts their physiological relevance. In an effort to create biomimetic collagen gels, approaches have been undertaken to generate osteoid-like environments with increased collagen concentrations, controlled fibrillar orientation, defined micro-architectures, and tailored mechanical properties. This review describes the state-of-the-art on collagen densification techniques, exploring their advantages, limitations and future perspectives for applications as bone grafts. Ultimately, by successfully mimicking the organic milieu of bone through acellular or cell-mediated mineralisation of the designed osteoid-like structure, functional collagen scaffolds with potential applications in bone tissue engineering can be realised. Abbreviations: 3D: three-dimensional; BG: bioactive glass; CFD: collagen fibrillar density; CHA: carbonated-hydroxyapatite; Col1: Type I collagen; ECM: extracellular matrix; GAE: gel aspiration-ejection; HHC: highly hydrated collagen; MSC: mesenchymal stem cell; NCPs: non-collagenous proteins; PC: plastic compression; PILP: polymer-induced liquid precursor; SBF: simulated body fluid
{"title":"Dense fibrillar collagen-based hydrogels as functional osteoid-mimicking scaffolds","authors":"Gabriele Griffanti, S. Nazhat","doi":"10.1080/09506608.2020.1735828","DOIUrl":"https://doi.org/10.1080/09506608.2020.1735828","url":null,"abstract":"ABSTRACT There is an increasing need to generate novel materials for the treatment and augmentation of bone defects, affecting millions of people worldwide. Fibrillar type I collagen is the most abundant tissue matrix protein in bone, providing its key native scaffolding material. However, while in vitro reconstituted collagen hydrogels of physically entangled, nano-fibred meshes, have long served as three-dimensional cultures, their highly-hydrated nature impacts their physiological relevance. In an effort to create biomimetic collagen gels, approaches have been undertaken to generate osteoid-like environments with increased collagen concentrations, controlled fibrillar orientation, defined micro-architectures, and tailored mechanical properties. This review describes the state-of-the-art on collagen densification techniques, exploring their advantages, limitations and future perspectives for applications as bone grafts. Ultimately, by successfully mimicking the organic milieu of bone through acellular or cell-mediated mineralisation of the designed osteoid-like structure, functional collagen scaffolds with potential applications in bone tissue engineering can be realised. Abbreviations: 3D: three-dimensional; BG: bioactive glass; CFD: collagen fibrillar density; CHA: carbonated-hydroxyapatite; Col1: Type I collagen; ECM: extracellular matrix; GAE: gel aspiration-ejection; HHC: highly hydrated collagen; MSC: mesenchymal stem cell; NCPs: non-collagenous proteins; PC: plastic compression; PILP: polymer-induced liquid precursor; SBF: simulated body fluid","PeriodicalId":14427,"journal":{"name":"International Materials Reviews","volume":"65 1","pages":"502 - 521"},"PeriodicalIF":16.1,"publicationDate":"2020-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/09506608.2020.1735828","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42883893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-05DOI: 10.1080/09506608.2020.1735829
S. Bahl, S. Suwas, K. Chatterjee
ABSTRACT Metastable β Ti alloys are widely projected for manufacturing the next generation of biomedical implants. The primary applications of these materials are envisaged in orthopedic, cardiovascular, and orthodontic biomedical devices. Development of an alloyprogresses through stages of compositional design, thermo-mechanical processing, and evaluation of material performance. This review tracks the progress at these three stages of alloy development particularly for use in orthopedic devices. The strategies to design low modulus compositions of β Ti alloys are critically reviewed. This is followed by the processing routes employed to achieve high strength to modulus ratio suitable for orthopedic applications. The effect of processing on performance metrics of these alloys vis-à-vis fatigue resistance, tribological response, corrosion behaviour, and biocompatibility are reviewed. In the end, targeted research areas for the future are highlighted along with encouraging strategies, with the aim to ensue clinical application of β Ti alloys.
{"title":"Comprehensive review on alloy design, processing, and performance of β Titanium alloys as biomedical materials","authors":"S. Bahl, S. Suwas, K. Chatterjee","doi":"10.1080/09506608.2020.1735829","DOIUrl":"https://doi.org/10.1080/09506608.2020.1735829","url":null,"abstract":"ABSTRACT Metastable β Ti alloys are widely projected for manufacturing the next generation of biomedical implants. The primary applications of these materials are envisaged in orthopedic, cardiovascular, and orthodontic biomedical devices. Development of an alloyprogresses through stages of compositional design, thermo-mechanical processing, and evaluation of material performance. This review tracks the progress at these three stages of alloy development particularly for use in orthopedic devices. The strategies to design low modulus compositions of β Ti alloys are critically reviewed. This is followed by the processing routes employed to achieve high strength to modulus ratio suitable for orthopedic applications. The effect of processing on performance metrics of these alloys vis-à-vis fatigue resistance, tribological response, corrosion behaviour, and biocompatibility are reviewed. In the end, targeted research areas for the future are highlighted along with encouraging strategies, with the aim to ensue clinical application of β Ti alloys.","PeriodicalId":14427,"journal":{"name":"International Materials Reviews","volume":"66 1","pages":"114 - 139"},"PeriodicalIF":16.1,"publicationDate":"2020-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/09506608.2020.1735829","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41723696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-02-17DOI: 10.1080/09506608.2018.1564545
P. Koštál, J. Shánělová, J. Málek
ABSTRACT Chalcogenide glass-formers are being used in a remarkable range of various optoelectronic, photonics, photoconducting, sensing and memory device applications. The knowledge of viscosity is essential for the processing of any glass-forming material, in particular for the fabrication of precise optical elements, which is the main application field of chalcogenide glasses. This work presents an extensive collection of all available viscosity data for chalcogenides, including the measurement methods. The Mauro–Yue–Ellison–Gupta–Allan (MYEGA), Arrhenius and VFT equations are used to fit the temperature dependences of viscosity. The viscosity glass transition temperatures, fragilities and apparent activation energies are calculated from these fits. Consequently, these parameters are discussed with regard to the compositional evolution of the respective chalcogenide systems.
{"title":"Viscosity of chalcogenide glass-formers","authors":"P. Koštál, J. Shánělová, J. Málek","doi":"10.1080/09506608.2018.1564545","DOIUrl":"https://doi.org/10.1080/09506608.2018.1564545","url":null,"abstract":"ABSTRACT Chalcogenide glass-formers are being used in a remarkable range of various optoelectronic, photonics, photoconducting, sensing and memory device applications. The knowledge of viscosity is essential for the processing of any glass-forming material, in particular for the fabrication of precise optical elements, which is the main application field of chalcogenide glasses. This work presents an extensive collection of all available viscosity data for chalcogenides, including the measurement methods. The Mauro–Yue–Ellison–Gupta–Allan (MYEGA), Arrhenius and VFT equations are used to fit the temperature dependences of viscosity. The viscosity glass transition temperatures, fragilities and apparent activation energies are calculated from these fits. Consequently, these parameters are discussed with regard to the compositional evolution of the respective chalcogenide systems.","PeriodicalId":14427,"journal":{"name":"International Materials Reviews","volume":"65 1","pages":"101 - 63"},"PeriodicalIF":16.1,"publicationDate":"2020-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/09506608.2018.1564545","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45171730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-02-16DOI: 10.1080/09506608.2019.1565716
M. Y. Mehr, A. Bahrami, W. D. V. Driel, Xuejun Fan, J. Davis, Guoqi Zhang
ABSTRACT In this paper, degradation mechanisms of optical materials, used in the light emitting diode (LED)-based products, are reviewed. The LED lighting is one of the fastest technology shifts in human history. Lighting accounts for almost 20% of the global electrical energy use, inferring that replacement of traditional lighting sources with LEDs with higher efficiencies will have major positive implications for the global energy consumption. Organic optical materials are key components in LEDs in the sense that they control the functionality of the device and they have decisive effects on the durability and reliability of LEDs. This paper aims at describing the influences of chemical structure and service conditions on the degradation mechanisms of organic optical materials in LEDs which lead to the lumen depreciation, discolouration, and colour shift of the LED light output. The contributions of different degradation mechanisms of optical and package materials in LED-based products to the lumen depreciation and colour shift are methodically reviewed.
{"title":"Degradation of optical materials in solid-state lighting systems","authors":"M. Y. Mehr, A. Bahrami, W. D. V. Driel, Xuejun Fan, J. Davis, Guoqi Zhang","doi":"10.1080/09506608.2019.1565716","DOIUrl":"https://doi.org/10.1080/09506608.2019.1565716","url":null,"abstract":"ABSTRACT In this paper, degradation mechanisms of optical materials, used in the light emitting diode (LED)-based products, are reviewed. The LED lighting is one of the fastest technology shifts in human history. Lighting accounts for almost 20% of the global electrical energy use, inferring that replacement of traditional lighting sources with LEDs with higher efficiencies will have major positive implications for the global energy consumption. Organic optical materials are key components in LEDs in the sense that they control the functionality of the device and they have decisive effects on the durability and reliability of LEDs. This paper aims at describing the influences of chemical structure and service conditions on the degradation mechanisms of organic optical materials in LEDs which lead to the lumen depreciation, discolouration, and colour shift of the LED light output. The contributions of different degradation mechanisms of optical and package materials in LED-based products to the lumen depreciation and colour shift are methodically reviewed.","PeriodicalId":14427,"journal":{"name":"International Materials Reviews","volume":"65 1","pages":"102 - 128"},"PeriodicalIF":16.1,"publicationDate":"2020-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/09506608.2019.1565716","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41741921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-02-10DOI: 10.1080/09506608.2020.1724705
Zhihua Zhou, Wei Wu, Jianjun Fang, Jingbo Yin
ABSTRACT For tissue regeneration or repair, a suitable temporary scaffold needs to be constructed for delivering regenerative cells to damaged or diseased tissue. Scaffold types are currently categorised into 3D monolithic scaffolds, hydrogels, and microcarriers. Among these scaffolds, microcarrier systems offer an attractive method for cell amplification and enhancement of phenotype expression, and they have emerged as powerful injectable carriers to repair and reconstruct irregular defects in tissues and organs. In this article, several important issues related to polymeric porous microcarriers for tissue engineering are reviewed. The properties of porous microcarriers, including surface chemistry, pore structure, typical particle size, and specific density, and the corresponding effects on cell cultures are discussed. The fabrication techniques and biomaterials investigated for porous microcarriers are summarised, and their advantages and disadvantages are outlined. Recent advancements in the application of porous microcarriers, including bone and cartilage tissue engineering, are also presented.
{"title":"Polymer-based porous microcarriers as cell delivery systems for applications in bone and cartilage tissue engineering","authors":"Zhihua Zhou, Wei Wu, Jianjun Fang, Jingbo Yin","doi":"10.1080/09506608.2020.1724705","DOIUrl":"https://doi.org/10.1080/09506608.2020.1724705","url":null,"abstract":"ABSTRACT For tissue regeneration or repair, a suitable temporary scaffold needs to be constructed for delivering regenerative cells to damaged or diseased tissue. Scaffold types are currently categorised into 3D monolithic scaffolds, hydrogels, and microcarriers. Among these scaffolds, microcarrier systems offer an attractive method for cell amplification and enhancement of phenotype expression, and they have emerged as powerful injectable carriers to repair and reconstruct irregular defects in tissues and organs. In this article, several important issues related to polymeric porous microcarriers for tissue engineering are reviewed. The properties of porous microcarriers, including surface chemistry, pore structure, typical particle size, and specific density, and the corresponding effects on cell cultures are discussed. The fabrication techniques and biomaterials investigated for porous microcarriers are summarised, and their advantages and disadvantages are outlined. Recent advancements in the application of porous microcarriers, including bone and cartilage tissue engineering, are also presented.","PeriodicalId":14427,"journal":{"name":"International Materials Reviews","volume":"66 1","pages":"77 - 113"},"PeriodicalIF":16.1,"publicationDate":"2020-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/09506608.2020.1724705","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46673619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-09DOI: 10.1080/09506608.2019.1709354
A. Reichardt, A. Shapiro, R. Otis, R. P. Dillon, J. Borgonia, B. McEnerney, P. Hosemann, A. Beese
ABSTRACT Over the 2010s technological improvements allowed metal additive manufacturing to graduate from a prototyping tool to a widespread, full-scale manufacturing process. Among the capabilities still under development, however, is the ability to locally tailor alloy composition and properties to fabricate bulk, complex geometry functionally graded materials (FGMs), eliminating the need for dissimilar-metal welds and joints. The challenge of compositional grading involves overcoming chemical, metallurgical, and thermal property differences to achieve a continuous structure between a wide range of selected combinations of alloys. In this review, examples are discussed of fabricating FGMs joining a variety of combinations of stainless, nickel, titanium and copper alloys, and FGMs joining metals to ceramics and metal-matrix composites. The change in design strategy enabled by practical FGMs may lead to effective use of biomimetic designs that are both much more efficient as well as aesthetically pleasing.
{"title":"Advances in additive manufacturing of metal-based functionally graded materials","authors":"A. Reichardt, A. Shapiro, R. Otis, R. P. Dillon, J. Borgonia, B. McEnerney, P. Hosemann, A. Beese","doi":"10.1080/09506608.2019.1709354","DOIUrl":"https://doi.org/10.1080/09506608.2019.1709354","url":null,"abstract":"ABSTRACT Over the 2010s technological improvements allowed metal additive manufacturing to graduate from a prototyping tool to a widespread, full-scale manufacturing process. Among the capabilities still under development, however, is the ability to locally tailor alloy composition and properties to fabricate bulk, complex geometry functionally graded materials (FGMs), eliminating the need for dissimilar-metal welds and joints. The challenge of compositional grading involves overcoming chemical, metallurgical, and thermal property differences to achieve a continuous structure between a wide range of selected combinations of alloys. In this review, examples are discussed of fabricating FGMs joining a variety of combinations of stainless, nickel, titanium and copper alloys, and FGMs joining metals to ceramics and metal-matrix composites. The change in design strategy enabled by practical FGMs may lead to effective use of biomimetic designs that are both much more efficient as well as aesthetically pleasing.","PeriodicalId":14427,"journal":{"name":"International Materials Reviews","volume":"66 1","pages":"1 - 29"},"PeriodicalIF":16.1,"publicationDate":"2020-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1080/09506608.2019.1709354","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44299114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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