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A Study of Cervical Cytological Changes in Hiv Positive Patients Hiv阳性患者宫颈细胞学变化的研究
Pub Date : 2017-07-01 DOI: 10.9790/0853-1606123948
Dr. Maruthi Devi Karri, Dr. Sudhakar Ghanta, Dr. Padmavathi Devi Chaganti, Dr. Sailabala Garikaparthi
Background: Gynaecological conditions are extremely common among women infected with Human Immunodeficiency Virus. These include pelvic inflammatory disease, Sexually Transmitted Diseases like syphilis, Herpes, Cytomegalo virus, Vulvovaginal Candidiasis etc. Objectives: The purpose of the study is to characterize the cervical cytological changes in HIV seropositive women. Materials & Methods: This cross sectional study was based on 200 patients with HIVinfection /AIDS, who attended the department of pathology and Gynaecology , Guntur medical college,Guntur. Results: The study revealed maximum number of inflammatory smears (81.3%), followed by smears showing squamous intra epithelial lesion (13.82%). Conclusion: PAP smear can be recommended as a part of routine medical examination in gynaecological practice as it is a simple, cost effective, low risk procedure.
背景:妇科疾病在感染人类免疫缺陷病毒的妇女中极为常见。这些疾病包括盆腔炎、性传播疾病如梅毒、疱疹、巨细胞病毒、外阴阴道念珠菌病等。目的:研究HIV血清阳性妇女宫颈细胞学变化的特征。材料与方法:本横断面研究基于200名在贡图尔市贡图尔医学院病理和妇科就诊的艾滋病毒感染/艾滋病患者。结果:炎性涂片最多(81.3%),其次为鳞状上皮内病变(13.82%)。结论:宫颈抹片检查是一种简单、经济、低风险的常规妇科检查方法。
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引用次数: 0
The Increase Of Tooth Enamel Hardness Score After Cow Milk Immersion Compared To Artificial Saliva On Demineralized Tooth 牛奶浸泡与人工唾液对脱矿牙釉质硬度评分的影响
Pub Date : 2017-07-01 DOI: 10.9790/0853-1606130610
Yendriwati Yendriwati, RizkaMalisa Sinaga
Soft drinks and fruit juices with lower acidic pH have become popular beverages in communities. Acidic beverages resulting demineralization on tooth cause a decrease of enamel hardness. In oral cavity, demineralized tooth is rescued by the buffering capacity of saliva as well as by drinking milk to accelerate tooth enamel remineralization. The aim of this study was to investigate the difference of enamel hardness score on tooth immersed in artificial saliva and cow milk. The present study was an experimental laboratory with pre and post test design. Thirty two maxillary first premolars were collected and randomly divided into 2 groups, with 16 samples each immersed in artificial saliva and cow milk. Samples were immersed in acidic solution for 5 min prior to exposing to cow milk (group 1) or artificial saliva (group 2) for 5 min twice a day until day3. Enamel hardness score was measured as follows : pre-treatment, post demineralization stage, and post treatment at day1 and day3 by Microvickers Hardness Tester. Data were analyzed using paired t-test and one way ANOVA. There was a significant difference (p=0,000) on enamel hardness score of group 1 at day1 (324,39±20.35 VHN) and day3 (354,80±21.09 VHN), as well as group 2 at day1 (308,06±15,94 VHN) and day3 (322,18±16.94 VHN). Tooth enamel hardness on group 1 was significantly different to group 2 both at day1 (p=0,018) and day3 (p=0,000). Those results suggest that artificial saliva and cow milk are able to increase the enamel hardness score. However, the efficacy of cow milk to augment the tooth enamel hardness is much higher than of artificial saliva is.
酸性pH值较低的软饮料和果汁已成为社区中受欢迎的饮料。酸性饮料导致牙齿脱矿,导致牙釉质硬度下降。在口腔中,脱矿的牙齿是通过唾液的缓冲能力以及喝牛奶来加速牙釉质再矿化来拯救的。本研究的目的是探讨人工唾液和牛奶浸泡后牙釉质硬度评分的差异。本研究采用前后试验设计的实验实验室。采集32颗上颌第一前磨牙,随机分为2组,每组16颗分别浸泡人工唾液和牛奶。样品在酸性溶液中浸泡5min,然后暴露于牛奶(组1)或人工唾液(组2)中5min,每天两次,直到第3天。采用显微硬度计测定牙釉质硬度评分:处理前、脱矿后、处理后第1天、第3天。数据分析采用配对t检验和单因素方差分析。组1和组2牙釉质硬度评分分别在第1天(324、39±20.35 VHN)和第3天(354、80±21.09 VHN)、第1天(308、06±15、94 VHN)和第3天(322、18±16.94 VHN)差异有统计学意义(p= 0000)。1组牙釉质硬度在第1天(p= 0.018)和第3天(p= 0000)均与2组有显著差异。结果表明,人工唾液和牛奶能提高牙釉质硬度评分。然而,牛奶对牙釉质硬度的增强效果远远高于人工唾液。
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引用次数: 3
Bone Marrow Study in Patients of Pancytopenia 全血细胞减少症患者的骨髓研究
Pub Date : 2017-07-01 DOI: 10.9790/0853-160702109113
Dr.Sapna Dhakad, S. Iyengar, Bharat Jain
Introduction: Pancytopenia is defined as reduction in all three major componpents of blood,results from number of disease processes. Pancytopenia develops by varieties of mechanism, due to decrease in haematopoeitic cell production as a result of destruction of marrow by toxins suppression of normal growth and differentiation. Patients present with anaemia leucopenia and thrombocytopenia Material And Methods: This is study done retrospectively of 80 patients from january 2015 to december 2016(2 year study), presenting with pancytopenia, in central pathology lab of Gajra Raja medical College Gwalior in which both peripheral smear and bone marrow of same patient is examined aftre staining with leishman stain under low and high magnification and all haematological parameters were seen. Bone marrow is evaluated for cellularity,erythropoiesis,myelopoiesis,megakaryopoiesis and other cells. Results: Among 80 cases studied,age of patients ranged from 1 to 70 with male to female ratio 2:1. Maximum number of cases were found in in the age group of 1 – 15yrs(62.5%) 15-35(25%) and >35 yrs(12.5%).most of the patients (>80%) had haemoglobin less than 5 grams,.more than 60% had mcv more than 100fml.In bone marrow studies we have found that myeloid series is suppressed in more than 60%patients and its normal in other patients.Myeloid erythroid ratio is suppressed in 70%of the cases.
全血细胞减少症被定义为血液中所有三种主要成分的减少,由疾病过程的数量引起。全血细胞减少症的发生机制多种多样,由于毒素破坏骨髓,抑制正常生长和分化,导致造血细胞产生减少。材料和方法:回顾性研究了2015年1月至2016年12月在Gajra Raja医学院galior中心病理实验室进行的80例全血细胞减少患者(为期2年)的研究,在低倍和高倍放大镜下用利什曼染色检查同一患者的外周血涂片和骨髓,观察所有血液学参数。评估骨髓的细胞性、红细胞生成、骨髓生成、巨核生成和其他细胞。结果:80例患者年龄1 ~ 70岁,男女比例2:1。以1 ~ 15岁年龄组(62.5%)、15 ~ 35岁年龄组(25%)和>35岁年龄组(12.5%)最多。大多数患者(>80%)血红蛋白低于5克。超过60%的患者MCV超过100fml。在骨髓研究中,我们发现髓系在60%以上的患者中受到抑制,而在其他患者中正常。70%的病例髓系红细胞比例受到抑制。
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引用次数: 2
Correlation Study of Sfrp2 And Β-Catenin With Colorectal Carcinogenesi srp2和Β-Catenin与结直肠癌的相关性研究
Pub Date : 2017-07-01 DOI: 10.9790/0853-1607026774
Youquan Shi, Yang Chong, Qingquan Xiong, Yuqin Huang, Huaicheng Zhou, Qi Zhang, Zhixiang Jin, D. Tang, Daorong Wang
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引用次数: 0
Percutaneous balloon mitral valvuloplasty in severe restenosis of the mitral valve: Analysis of factors affecting the short term outcomes – A single center experience 经皮二尖瓣球囊成形术治疗严重二尖瓣再狭窄:影响短期结果的因素分析-单中心经验
Pub Date : 2017-07-01 DOI: 10.9790/0853-1607022734
Srinivas Bhyravavajhala, K. Ravella, S. Yerram, S. Akula, D. Rao
Introduction: Rheumatic heart disease (RHD) is still a major problem in developing countries, with mitral stenosis being the most frequent manifestation. Percutaneous mitral valvuloplasty has emerged as the procedure of choice in most patients with symptomatic mitral stenosis. Late recurrence of symptoms after the procedure is mostly related to mitral restenosis. A few reports are available about percutaneous valvuloplasty in restenosis of the mitral valve, but factors predicting the outcomes are not clear. In this study we tried to explore clinical characters and short term out-comes of percutaneous balloon mitral valvuloplasty in symptomatic severe mitral restenosis. Materials and methods: Thirty five consecutive inpatients who underwent percutaneous balloon mitral valvuloplasty (PBMV) for symptomatic and severe mitral restenosis after previous surgery or valvuloplasty were included in this single center prospective study. Comprehensive transthoracic and transesophageal echocardiographic examination was done and mitral valve morphology was assessed. To define more accurately the relation between the mechanism of restenosis and the immediate results of repeat PBMV, we focused on commissural morphology and sub classified patients into 2 groups: patients with bilateral fused commissures and patients with either unilateral or bilateral split commissures. PBMV was done according to standard technique. Procedural success was defined as an increase of 50% of mitral valve area or a final area of 1.5cm 2 , with no more than one grade increment in MR severity assessed by echocardiography 24 hours after the procedure. Patients with persistent left atrial or left atrial appendage thrombus, more than moderate mitral regurgitation(MR), severe or bicommissural calcification, severe concomitant aortic valve disease, severe organic tricuspid stenosis, severe concomitant coronary artery disease requiring bypass surgery and severe subvalve disease were excluded from the study. Results: A total of 35 patients were enrolled into the study (mean age 37.51±10.29 years). Of these 35 patients, 22 (62.8%) were males and 13 (37.14%) were females. patients were divided into two groups as group 1 (bilaterally fused commissure ) and group 2 (one split commissure) Bilateral fused commisures were in 7 patients and either of commissure was split in remaining 28 patients. Mean age of the study population was 37.51±10.29 years. Mean mitral valve area was 1.02±0.15 (cm 2 ) and 1.07±0.19 (cm 2 ) in either commissure split and bilateral fused commisures groups respectively (p =0.23). Mean mitral valve gradient, peak mitral valve gradient, systolic pulmonary artery pressure and LA size were not statistically significant between two groups. LA thrombus was absent in both the groups. average Post PTMC mitral valve area in bilateral fused commisures group was 1.77±0.09 cm 2 and in either of commissure split group was 1.52±0.42 cm 2 (p =0.001). Mean mitral valve gradients were 5.04±1.69
风湿性心脏病(RHD)仍然是发展中国家的一个主要问题,二尖瓣狭窄是最常见的表现。经皮二尖瓣成形术已成为大多数症状性二尖瓣狭窄患者的首选手术方法。术后症状的晚期复发主要与二尖瓣再狭窄有关。有一些关于经皮二尖瓣成形术治疗二尖瓣再狭窄的报道,但预测结果的因素尚不清楚。在本研究中,我们试图探讨经皮球囊二尖瓣成形术治疗严重二尖瓣再狭窄的临床特点和短期疗效。材料和方法:本研究纳入了35例连续住院的经皮球囊二尖瓣成形术(PBMV)治疗既往手术或二尖瓣成形术后出现症状和严重二尖瓣再狭窄的患者。经胸、经食管超声心动图检查,评估二尖瓣形态。为了更准确地确定再狭窄的机制与重复PBMV的直接结果之间的关系,我们重点研究了联合形态学,并将患者分为两组:双侧融合的患者和单侧或双侧分离的患者。按标准方法行PBMV。手术成功定义为二尖瓣面积增加50%或最终面积1.5cm 2,术后24小时超声心动图评估MR严重程度不超过1级。持续性左心房或左心房附件血栓、中度以上二尖瓣反流(MR)、严重或双侧钙化、严重合并主动脉瓣疾病、严重器质性三尖瓣狭窄、严重合并需要搭桥手术的冠状动脉疾病和严重瓣下疾病的患者被排除在研究之外。结果:共有35例患者入组,平均年龄37.51±10.29岁。其中男性22例(62.8%),女性13例(37.14%)。将患者分为两组:1组(双侧融合)和2组(单侧分离融合)7例双侧融合,其余28例双侧分离。研究人群的平均年龄为37.51±10.29岁。两组的平均二尖瓣面积分别为1.02±0.15 (cm2)和1.07±0.19 (cm2),差异有统计学意义(p =0.23)。两组间平均二尖瓣梯度、尖峰二尖瓣梯度、肺动脉收缩压、LA大小差异均无统计学意义。两组均未见LA血栓形成。双侧融合融合组PTMC术后二尖瓣平均面积为1.77±0.09 cm 2,双侧融合分离组平均面积为1.52±0.42 cm 2 (p =0.001)。平均二尖瓣梯度分别为5.04±1.69 mmHg和3.71±4.08 mmHg (p=0.025),峰值二尖瓣梯度分别为9.54±2.52和7.14±3.39 (p=0.02),两组差异均有统计学意义。两组患者肺动脉收缩压差异无统计学意义。本研究中,30例(85.78%)患者获得最佳结果,5例(14.22%)患者获得次优结果,其中3例(8.5%)患者二尖瓣面积不足,2例(5.7%)患者出现二尖瓣返流。MR与迁移率呈微负相关(相关系数-0.1)(P= 0.546),厚度与MR的发展呈正相关(P= 0.0000001系数0.98),且高度相关。但mri的发展与二尖瓣前面积总体(cc 0.189 p= 0.138)或连接分裂(cc 0.108 p=0.2684)双二尖瓣融合(cc 0.158 p=0.182)在严重二尖瓣再狭窄中经皮球囊二尖瓣成形术无关:....分析DOI: 10.9790/0853-1607022734 www.iosrjournals.org 28 |页面结论:委员会形态是最重要的预测结果PBMV在再狭窄的瓣膜。超声心动图的充分评估提高了PBMV的成功率,降低了并发症的发生率。
{"title":"Percutaneous balloon mitral valvuloplasty in severe restenosis of the mitral valve: Analysis of factors affecting the short term outcomes – A single center experience","authors":"Srinivas Bhyravavajhala, K. Ravella, S. Yerram, S. Akula, D. Rao","doi":"10.9790/0853-1607022734","DOIUrl":"https://doi.org/10.9790/0853-1607022734","url":null,"abstract":"Introduction: Rheumatic heart disease (RHD) is still a major problem in developing countries, with mitral stenosis being the most frequent manifestation. Percutaneous mitral valvuloplasty has emerged as the procedure of choice in most patients with symptomatic mitral stenosis. Late recurrence of symptoms after the procedure is mostly related to mitral restenosis. A few reports are available about percutaneous valvuloplasty in restenosis of the mitral valve, but factors predicting the outcomes are not clear. In this study we tried to explore clinical characters and short term out-comes of percutaneous balloon mitral valvuloplasty in symptomatic severe mitral restenosis. Materials and methods: Thirty five consecutive inpatients who underwent percutaneous balloon mitral valvuloplasty (PBMV) for symptomatic and severe mitral restenosis after previous surgery or valvuloplasty were included in this single center prospective study. Comprehensive transthoracic and transesophageal echocardiographic examination was done and mitral valve morphology was assessed. To define more accurately the relation between the mechanism of restenosis and the immediate results of repeat PBMV, we focused on commissural morphology and sub classified patients into 2 groups: patients with bilateral fused commissures and patients with either unilateral or bilateral split commissures. PBMV was done according to standard technique. Procedural success was defined as an increase of 50% of mitral valve area or a final area of 1.5cm 2 , with no more than one grade increment in MR severity assessed by echocardiography 24 hours after the procedure. Patients with persistent left atrial or left atrial appendage thrombus, more than moderate mitral regurgitation(MR), severe or bicommissural calcification, severe concomitant aortic valve disease, severe organic tricuspid stenosis, severe concomitant coronary artery disease requiring bypass surgery and severe subvalve disease were excluded from the study. Results: A total of 35 patients were enrolled into the study (mean age 37.51±10.29 years). Of these 35 patients, 22 (62.8%) were males and 13 (37.14%) were females. patients were divided into two groups as group 1 (bilaterally fused commissure ) and group 2 (one split commissure) Bilateral fused commisures were in 7 patients and either of commissure was split in remaining 28 patients. Mean age of the study population was 37.51±10.29 years. Mean mitral valve area was 1.02±0.15 (cm 2 ) and 1.07±0.19 (cm 2 ) in either commissure split and bilateral fused commisures groups respectively (p =0.23). Mean mitral valve gradient, peak mitral valve gradient, systolic pulmonary artery pressure and LA size were not statistically significant between two groups. LA thrombus was absent in both the groups. average Post PTMC mitral valve area in bilateral fused commisures group was 1.77±0.09 cm 2 and in either of commissure split group was 1.52±0.42 cm 2 (p =0.001). Mean mitral valve gradients were 5.04±1.69","PeriodicalId":14489,"journal":{"name":"IOSR Journal of Dental and Medical Sciences","volume":"21 1","pages":"27-34"},"PeriodicalIF":0.0,"publicationDate":"2017-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84674452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy of Post Operative Analgesia with Epidural Tramadol, Fentanyl And Buprenorphine 硬膜外曲马多、芬太尼、丁丙诺啡术后镇痛效果观察
Pub Date : 2017-07-01 DOI: 10.9790/0853-160603139146
Lokesh Naik, B. Rao, .. R.PanduNaik
Aim : To compare postoperative analgesia among epidural Tramadol, Fentanyl & Buprenorphine over first 24 hours in terms of onset of analgesia, duration, quality of analgesia, number of doses, haemodynamic parameters, respiratory rate and side effects. Methods And Materials: This study was a prospective comparative randomized study. After ethical committee approval a total of 60 patients undergoing elective lower limb or lower abdominal surgeries : were divided into three groups (Group T, Group F and Group B) of twenty each. All the patients were premedicated with Tab. Alprazolam 0.25 mg at 10pm night before surgery and Tab.Ranitidine 150 mg at 7am on day of surgery . Results. The demographic profile (age wise and weight wise distribution) was comparable in all the three groups. The onset of analgesia was shortest (3.75 ± 0.36 min) in fentanyl group followed by tramadol (7.76 ± 0.65 min) and buprenorphine (13.98 ± 1.46 min) groups which is statistically significant. The duration of analgesia was 232.25 ± 19.15 min in fentanyl group, 434.75 ± 33.61 min in tramadol group and 1094 ± 27.29 min in buprenorphine group which is statistically significant. The number of doses required in fentanyl group are 6.7 ± 0.7, tramadol group are 4.0 ± 0.0 and buprenorphine group are 2.0 ± 0.0. The quality of analgesia which was assessed using VAS score showed that the score was less than 1 in all the groups during 24hrs of study period. The changes in systolic blood pressures recorded at 0, 1, 2, 3, 4, 5, 8, 9, 10, 11, 12, 18 and 24 hrs among the three groups were statistically not significant. The increase observed at 6 and 7 hrs in tramadol and fentanyl groups compared with buprenorphine group was statistically significant which can be explained based on shorter duration of action of tramadol and fentanyl leading to wearing of the analgesic effect. Respiratory rate showed no significant changes at 0, 1, 2, 3, 4, 5, 8, 9, 10, 11, 12, 18 and 24 hrs among the three groups statistically. The decrease in respiratory rate in buprenorphine group compared to tramadol and fentanyl groups was statistically significant at 6 and 7 hrs. Conclusion: With advent of newer opioids with fewer side effects, the search for appropriate opioid for epidural administration to provide postoperative pain relief still continues. With the introduction of infusion pump in postoperative ward further research can be directed towards patient controlled analgesia and continuous
目的:比较曲马多、芬太尼和丁丙诺啡在术后24小时硬膜外镇痛的起效、持续时间、镇痛质量、给药次数、血流动力学参数、呼吸频率和副作用。方法与材料:本研究为前瞻性比较随机研究。经伦理委员会批准,将择期下肢或下腹部手术患者60例分为T组、F组、B组,每组20例。所有患者均预先给予Tab。术前晚10点服用阿普唑仑0.25 mg。雷尼替丁150毫克,手术当天早上7点。结果。人口统计资料(年龄和体重分布)在所有三组中具有可比性。芬太尼组镇痛时间最短,为3.75±0.36 min,其次为曲马多组(7.76±0.65 min),丁丙诺啡组(13.98±1.46 min),差异有统计学意义。芬太尼组镇痛时间为232.25±19.15 min,曲马多组为434.75±33.61 min,丁丙诺啡组为1094±27.29 min,差异有统计学意义。芬太尼组为6.7±0.7次,曲马多组为4.0±0.0次,丁丙诺啡组为2.0±0.0次。采用VAS评分对镇痛质量进行评价,研究期间24小时各组镇痛质量评分均小于1分。各组在0、1、2、3、4、5、8、9、10、11、12、18、24 h收缩压变化均无统计学意义。与丁丙诺啡组相比,曲马多组和芬太尼组在6和7小时的镇痛效果增加有统计学意义,这可能是由于曲马多和芬太尼的作用时间较短,导致镇痛效果减弱。3组患者在0、1、2、3、4、5、8、9、10、11、12、18、24 h呼吸频率差异无统计学意义。与曲马多和芬太尼组相比,丁丙诺啡组呼吸频率在6和7 h时下降有统计学意义。结论:随着副作用更小的新型阿片类药物的出现,寻找合适的阿片类药物用于硬膜外给药以缓解术后疼痛仍在继续。随着输液泵在术后病房的引入,进一步的研究可以指向患者自控镇痛和持续镇痛
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引用次数: 1
Angiomyofibroblastoma Arising From The Pouch of Douglas: A Rare Case Report (16 Bold) 起源于道格拉斯眼袋的血管肌成纤维细胞瘤1例(16 Bold)
Pub Date : 2017-07-01 DOI: 10.9790/0853-1606125860
Dr H. S. Kumar, A. Heroor, Arul Vanan, P. Pawar
Introduction: Angiomyofibroblastoma (AMF) is a rare soft-tissue tumor that most frequently affects the lower genital tracts of young to middle-aged women. These tumors commonly involve the vulva, perineum, vagina, uterine cervix but only rarely occur in the pelvis or retroperitoneum and rarely the inguinoscrotal regions of men. No case till date reported of AMF that originated from POD. To our knowledge, only FIVE cases of pelvic AMF have been reported at least so far. Case Report: A 44 years old woman presented with intermittent dysuria & UTI since 1 year. Her medical history was unremarkable. Her menstrual cycle was regular, painless, not have dysmenorrhoea or menorrhagia. A physical examination didn’ t ravel abnormalities. CT & MRI suggest soft tissue tumor between uterus & rectum. She was operated & HPR leads diagnosis of AMF of POD. Conclusion: AMF of POD is extremely rare but is benign. a recognition of this entity is important to avoid misdiagnosis of other angiomyxoid neoplasms,leiomyoma. Preoperative diagnosis & differentiation of AMF from other soft tissue tumor are challenging. The combination of radiological data, & histological and IHC findings can confirm the diagnosis. It is important to identity this entity so that the patient can be saved from unnecessary follow up and intervention post excision.
血管肌成纤维细胞瘤(AMF)是一种罕见的软组织肿瘤,最常影响年轻至中年妇女的下生殖道。这些肿瘤通常累及外阴、会阴、阴道、子宫颈,但很少发生在骨盆或腹膜后,很少发生在男性的腹股沟阴囊区域。到目前为止,还没有报告来自POD的AMF病例。据我们所知,至少到目前为止,只有5例盆腔AMF被报道。病例报告:一名44岁女性,1年来出现间歇性排尿困难和尿路感染。她的病史一般。月经周期规律,无痛,无痛经、月经过多。体检没有发现异常。CT及MRI提示子宫与直肠间软组织肿瘤。患者接受手术,HPR诊断为POD型AMF。结论:POD的AMF极为罕见,且为良性。认识到这个实体是重要的,以避免误诊其他血管粘液样肿瘤,平滑肌瘤。AMF与其他软组织肿瘤的术前诊断和鉴别具有挑战性。结合放射学资料、组织学和免疫组化检查结果可证实诊断。重要的是要确定这个实体,以便患者可以从不必要的随访和干预手术后保存。
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引用次数: 0
Biochemical abnormalities in OPC poisoning and its prognostic significance OPC中毒的生化异常及其预后意义
Pub Date : 2017-07-01 DOI: 10.9790/0853-160701116119
Dr.N.K .SenthilnathanMD, Dr.L.Alen Binny
BACKGROUND: Organophosphorus insecticides are arguably one of the commonest causes of morbidity and mortality due to poisoning worldwide, especially in developing countries like India due to its easy availability. Though Serum cholinesterase can be a useful tool in the diagnosis of OP poisoning, its role in prognostication is very minimal. Our study was conducted to other biochemical abnormalities to predict the severity and prognosis in OP poisoning patients. AIMS AND OBJECTIVES: (1)To measure serum electrolytes, liver enzymes, amylase, CPK, CPK-MB, and Troponin I in acute organophosphorus poisoning (2) To analyse the correlation between these biochemical parameters and serum acetylcholinesterase levels (3) To analyse the validity of these biochemical parameters in prediction of severity and prognosis in op poisoning. MATERIALS AND METHODS:This study was conducted over a period of 1 year in Mahatma Gandhi Memorial Government Hospital attached to K.A.P.V Govt Medical College, Trichy wherein 50 OP poisoning patients were selected using inclusion and exclusion criteria and their blood samples were collected on admission and analysed for the above said biochemical parameters. RESULTS: 74% of the patients were male, and 62% of the patients fall in the age group of 20 to 30 years. Statistically significant elevation of ALT, CPK, CPK-MB and Troponin I were noted in the study group. A significant fall in serum potassium level in also noted. Most of the patients in the study had a cholinesterase level of 20% to 50%. CONCLUSION: AST, ALT, ALP, and Amylase increase in acute OP poisoning. Rise in CPK, CPK-MB, Troponin I and ALT indicate the severity of OP poisoning and is also statistically significant to predict the prognosis of the patient. Hypokalaemia and associated low cholinesterase levels indicate the requirement of ventilator support and also the poor prognosis of the patient. These findings can assist health professionals to better evaluate patient’s prognosis and improve their treatment plan.
背景:有机磷杀虫剂可以说是世界范围内最常见的中毒发病和死亡原因之一,特别是在印度等发展中国家,因为有机磷杀虫剂很容易获得。虽然血清胆碱酯酶是诊断OP中毒的有用工具,但其在预后中的作用很小。我们通过其他生化异常来预测OP中毒患者的严重程度和预后。目的和目的:(1)测定急性有机磷中毒患者血清电解质、肝酶、淀粉酶、CPK、CPK- mb、肌钙蛋白I (Troponin I)的变化;(2)分析这些生化指标与血清乙酰胆碱酯酶水平的相关性;(3)分析这些生化指标预测有机磷中毒严重程度和预后的有效性。材料与方法:本研究在特里希市K.A.P.V政府医学院附属的圣雄甘地纪念政府医院进行了为期1年的研究,其中采用纳入和排除标准选择了50例OP中毒患者,并在入院时采集血样并分析上述生化参数。结果:74%的患者为男性,62%的患者年龄在20 ~ 30岁。研究组ALT、CPK、CPK- mb、肌钙蛋白I升高均有统计学意义。血清钾水平也显著下降。研究中大多数患者的胆碱酯酶水平在20%到50%之间。结论:急性OP中毒时AST、ALT、ALP和淀粉酶升高。CPK、CPK- mb、Troponin I、ALT升高反映OP中毒的严重程度,对预测患者预后也有统计学意义。低钾血症和相关的低胆碱酯酶水平表明需要呼吸机支持,也表明患者预后不良。这些发现可以帮助卫生专业人员更好地评估患者的预后并改进他们的治疗计划。
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引用次数: 6
Knowledge, Attitude and Willingness for Eye Donation in General Population of Odisha inEastern India 印度东部奥里萨邦普通民众对眼部捐赠的知识、态度和意愿
Pub Date : 2017-07-01 DOI: 10.9790/0853-1607010106
Suchitra Panigrahi, B. Rath, R. Sahu, S. Rath, S. Sethi, Kasturi Mahapatra
Aim: To assess the knowledge,attitude and willingness of general population towards eye donation which includes patients and their attendants attending the outpatient department of a tertiary care medical college hospital of southern Orissa, Eastern India. Materials and methods: 452 participants were administered a pretested semi-structured questionnaire. Chisquare test was used to determine the factors associated with willingness towards eye donation. Data was analysed using Graphpad prism version 7.0 Results: In this study 247(54.6%) participants were willing to pledge for eye donation ,there was significant association of willingness to donate eyes among males159 (64.1%) , among participants below 40 years of age175 (75.2%),participants with higher education status146 (82.9%) and urban population147 (70.6%) .Perceived reasons among 205 (45.3%) who were not willing to pledge were,137(66.8%) need more information regarding eye donation,52(25.3%) thought family may not allow for eye donation and 16(7.8%) participants did not want to pledge due to religious disbelief.Media played a major role in creating awareness for eye donation. Conclusion:Multipronged innovative strategies should be adopted to increase the awareness regarding eye donation in less educated and rural population.
目的:了解印度东部奥里萨邦南部某三级专科医院门诊患者及其护理人员对眼部捐赠的知识、态度和意愿。材料与方法:对452名参与者进行预测半结构化问卷调查。使用Chisquare检验确定与眼部捐赠意愿相关的因素。使用Graphpad prism 7.0版本进行数据分析。在本研究中,247名(54.6%)参与者愿意捐献眼睛,其中男性捐献意愿显著相关159人(64.1%);40岁以下175人(75.2%),高学历146人(82.9%),城市人口147人(70.6%)。205人(45.3%)不愿意捐眼的原因为:需要了解更多有关捐眼的信息137人(66.8%),认为家人可能不允许捐眼的52人(25.3%),不愿意捐眼的16人(7.8%)。媒体在提高人们对眼部捐赠的认识方面发挥了重要作用。结论:应采取多管齐下的创新策略,提高教育程度较低和农村人群的眼部捐赠意识。
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引用次数: 5
Evaluation of Halopelvic Traction for Curve Correction in Spinal Deformities 固定式骨盆牵引对脊柱畸形弯曲矫正的疗效评价
Pub Date : 2017-07-01 DOI: 10.9790/0853-1606115056
Raj N. Singh, S. Sangwan, R. Bala, Vinit Verma, Krishna P Mazumdar, Z. Kundu, Kuldeep Singh
Introduction: The treatment of severe spinal deformities has always been a difficult task for surgeons. The treatment modalities range from minimal invasive to extensive mobilisation and instrumentation. Halo pelvic traction had proved to be quite effective in correction of these deformities. Hence we intended to study its role in our population with severe spinal deformities. Materials and Method: The present study involved 25 consenting patient with severe kyphoscoliosis. Preoperative examination and routine investigation were done. Halo-pelvic traction was applied after anterior release. Posterior Fusion was carried out after maximum possible correction achieved. HPT was removed after consolidation of fusion. Results: The Mean age was 13.88yrs with male:female ratio 1:1. The most common etiologies were congenital or idiopathic. HPT was applied for 22.7weeks. The mean correction of deformity achieved was 38.6 o . The complications were primarily minor and temporary. Overall satisfaction rate was good. Conclusions: The results of our study highlight the importance of HPT as simple and affordable equipment for correction of spinal deformities. The complications, though, do occur, but can be curtailed by careful and proper management.
对外科医生来说,严重脊柱畸形的治疗一直是一项艰巨的任务。治疗方式从微创到广泛的活动和器械。晕盆腔牵引已被证明是相当有效的矫正这些畸形。因此,我们打算研究其在严重脊柱畸形人群中的作用。材料和方法:本研究纳入25例重度脊柱后凸患者。术前检查及常规检查。前路松解后应用晕盆牵引。在达到最大可能的矫正后进行后路融合。融合巩固后取出HPT。结果:平均年龄13.88岁,男女比例1:1。最常见的病因是先天性或特发性。HPT治疗22.7周。平均畸形矫正率为38.6°。并发症主要是轻微和暂时的。总体满意度良好。结论:我们的研究结果强调了HPT作为简单和负担得起的脊柱畸形矫正设备的重要性。然而,并发症确实会发生,但可以通过仔细和适当的管理来减少。
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引用次数: 1
期刊
IOSR Journal of Dental and Medical Sciences
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