Pre-Menstrual Syndrome is a group of physical, psychological, and emotional symptoms that begins 7-14 days before menses and fade once menses begins. PMDD is a psychiatric diagnosis of PMS. The cause of PMS is unknown. Hence studies need to be conducted to know the various lifestyle and dietary habits that increases the risk of PMS. The aim was to study the dietary pattern of adolescent girls aged 17-19 years of Girls college of Hyderabad during the PMS period. The objectives were to study the prevalence, association between lifestyle habits, dietary pattern and stress with PMS in these adolescent girls. Adolescent girls of Girls College, answered a self- constructed, pre tested, standardized questionnaire for the prevalence study. Information on lifestyle and dietary habits, dietary preferences and symptoms observed in PMS period, and the observed stress level was collected. Chi – square test and non- parametric test was done to interpret the data. Among the 300 respondents, 19.3% had PMDD, 46.3% had moderate to severe PMS and 34.3% had mild/no PMS. There was an association between PMS and consuming high calorie foods, herbal teas during PMS period (p is less than 0.05) and also with stress (pis less than0.05) Reducing high calorie foods help to reduce PMS symptoms. Adequate sleep, less screen time and avoiding skipping of meals, consuming less fast food would reduce the prevalence. Having higher level of stress increases the risk of developing PMS or even PMDD.
{"title":"A STUDY ON PREVALENCE OF PRE MENSTRUAL SYNDROME, ITS ASSOCIATION WITH DIETARY HABITS AND STRESS LEVELS AMONG ADOLOSCENT GIRLS STUDYING IN GIRLS COLLEGE OF HYDERABAD","authors":"Bashama Zehra, Mrs. Meena Patangay","doi":"10.55218/jasr.202213910","DOIUrl":"https://doi.org/10.55218/jasr.202213910","url":null,"abstract":"Pre-Menstrual Syndrome is a group of physical, psychological, and emotional symptoms that begins 7-14 days before menses and fade once menses begins. PMDD is a psychiatric diagnosis of PMS. The cause of PMS is unknown. Hence studies need to be conducted to know the various lifestyle and dietary habits that increases the risk of PMS. The aim was to study the dietary pattern of adolescent girls aged 17-19 years of Girls college of Hyderabad during the PMS period. The objectives were to study the prevalence, association between lifestyle habits, dietary pattern and stress with PMS in these adolescent girls. Adolescent girls of Girls College, answered a self- constructed, pre tested, standardized questionnaire for the prevalence study. Information on lifestyle and dietary habits, dietary preferences and symptoms observed in PMS period, and the observed stress level was collected. Chi – square test and non- parametric test was done to interpret the data. Among the 300 respondents, 19.3% had PMDD, 46.3% had moderate to severe PMS and 34.3% had mild/no PMS. There was an association between PMS and consuming high calorie foods, herbal teas during PMS period (p is less than 0.05) and also with stress (pis less than0.05) Reducing high calorie foods help to reduce PMS symptoms. Adequate sleep, less screen time and avoiding skipping of meals, consuming less fast food would reduce the prevalence. Having higher level of stress increases the risk of developing PMS or even PMDD.","PeriodicalId":14906,"journal":{"name":"Journal of Advanced Scientific Research","volume":"59 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73719223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. J. Priya, C. Duraivathi, J. Poongodi, K. Amudhavalli
Iron doped cobalt oxide nanoparticles were prepared by using Eclipta alba leaves extract. The structural, optical and phase analysis of the synthesized nanoparticles are investigated by X-Ray Diffraction (XRD), Ultraviolet Visible Spectroscopy (UV), and Fourier Transform Infrared Spectroscopy (FTIR) respectively. Scanning Electron microscope (SEM), Energy Dispersive X-Ray Spectroscopy (EDX) and Dynamic Light Scattering (DLS) are used to study the surface morphological, elemental analysis and the hydrodynamic size of the prepared nanoparticles. Methylene Blue (MB) and Congo Red (CR) dye degradation efficacy of the iron doped cobalt oxide nanoparticles are examined using UV. Antibacterial activity for three different bacteria was done using disc diffusion method. Capacitative property of FeCo2O4 was proved by Cyclic Voltammetry (CV) analysis. Thermodynamic properties of the herbal synthesized particle were investigated using Ultrasonic technique using propylene glycol as a base fluid.
{"title":"HERBAL SYNTHESIS OF IRON DOPED COBALT OXIDE NANOPARTICLE AND ITS APPLICATIONS","authors":"J. J. Priya, C. Duraivathi, J. Poongodi, K. Amudhavalli","doi":"10.55218/jasr.202213908","DOIUrl":"https://doi.org/10.55218/jasr.202213908","url":null,"abstract":"Iron doped cobalt oxide nanoparticles were prepared by using Eclipta alba leaves extract. The structural, optical and phase analysis of the synthesized nanoparticles are investigated by X-Ray Diffraction (XRD), Ultraviolet Visible Spectroscopy (UV), and Fourier Transform Infrared Spectroscopy (FTIR) respectively. Scanning Electron microscope (SEM), Energy Dispersive X-Ray Spectroscopy (EDX) and Dynamic Light Scattering (DLS) are used to study the surface morphological, elemental analysis and the hydrodynamic size of the prepared nanoparticles. Methylene Blue (MB) and Congo Red (CR) dye degradation efficacy of the iron doped cobalt oxide nanoparticles are examined using UV. Antibacterial activity for three different bacteria was done using disc diffusion method. Capacitative property of FeCo2O4 was proved by Cyclic Voltammetry (CV) analysis. Thermodynamic properties of the herbal synthesized particle were investigated using Ultrasonic technique using propylene glycol as a base fluid.","PeriodicalId":14906,"journal":{"name":"Journal of Advanced Scientific Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77619452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Charu Jaiswal, Medha Chakraborty, Kushal Kant Pant, Vikas Chandra, D. Porte
Cancer refers to a collective group of diseases involving abnormal, uncontrolled cell proliferation with the potential to spread to the other tissues from the location of origin. Various modes of treatments such as radiotherapy, chemotherapy, surgical methods, etc. are commonly available. However, these approaches are not very cost-effective and are accompanied by side effects. An emerging approach of targeted drug delivery or smart drug delivery with the assistance of nanoparticles (NPs) and also in combination with immunological therapies has proven to show great potential in cancer treatment with an additional advantage of having the least side effects. Stimulus-sensitive smart nanomaterials have been designed to specifically target the cancer cells, causing no damage to the healthy cells. This is attained using Poly (lactic-co-glycolic acid) (PLGA), PEGylated NPs, αvβ3-integrin-specific lipid NPs, NP-based radiosensitizers (NBRs), and NP drones. Moreover, not only the specific targeting but the advances allow the detection of these drug-loaded NPs with the help of plasmonic Biosensor and fluorescence nanoprobes that emits fluorescence as it comes in contact with the target. This article describes the application of NPs in targeting the tumor cells as well as the recent researches going on to facilitate easier & cheaper modes of treatment using nanotechnology.
{"title":"NANOPARTICLE AIDED TUMOR TARGETING AND CANCER DETECTION","authors":"Charu Jaiswal, Medha Chakraborty, Kushal Kant Pant, Vikas Chandra, D. Porte","doi":"10.55218/jasr.202213901","DOIUrl":"https://doi.org/10.55218/jasr.202213901","url":null,"abstract":"Cancer refers to a collective group of diseases involving abnormal, uncontrolled cell proliferation with the potential to spread to the other tissues from the location of origin. Various modes of treatments such as radiotherapy, chemotherapy, surgical methods, etc. are commonly available. However, these approaches are not very cost-effective and are accompanied by side effects. An emerging approach of targeted drug delivery or smart drug delivery with the assistance of nanoparticles (NPs) and also in combination with immunological therapies has proven to show great potential in cancer treatment with an additional advantage of having the least side effects. Stimulus-sensitive smart nanomaterials have been designed to specifically target the cancer cells, causing no damage to the healthy cells. This is attained using Poly (lactic-co-glycolic acid) (PLGA), PEGylated NPs, αvβ3-integrin-specific lipid NPs, NP-based radiosensitizers (NBRs), and NP drones. Moreover, not only the specific targeting but the advances allow the detection of these drug-loaded NPs with the help of plasmonic Biosensor and fluorescence nanoprobes that emits fluorescence as it comes in contact with the target. This article describes the application of NPs in targeting the tumor cells as well as the recent researches going on to facilitate easier & cheaper modes of treatment using nanotechnology.","PeriodicalId":14906,"journal":{"name":"Journal of Advanced Scientific Research","volume":"46 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81077038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Scrub typhus, which is one of the rickettsial diseases, is an acute, febrile illness in men caused by the pathogen, 18 a gram-negative bacterium Orientia tsutsugamushi from the bite of infected mite. Outbreaks of scrub typhus have been reported from various parts of North, South, and Eastern India. There was a report of two unfortunate death cases from Cheural village due to scrub typhus at Lawngtlai district hospital. While, multiple cases, having symptoms like scrub typhus illness were also reported by health officials of the residents of Cheural village, Lawngtlai District, Mizoram. Among the 242 person tested, 80 (33.05%) person were found reactive with Weil felix PROGEN OXK at 1:160 titre value. Maximum numbers of cases were observed among the working age group 20-60 years. Among the different occupational groups, farmers were the most affected as more than 90% of the villagers were involved in forest farming. The five captured rodents’ sera were also tested with Weil felix. All of the captured rodent sera were reactive with one or more antigen. Mites (chigger) were also collected from the rodent samples and the chigger index was found to be 19.2. This study indicated that scrub typhus and other rickettsial diseases were responsible for the outbreak. The extremely high chigger index with reactivity rate reactivity rate of Weil felix with sera of captured rodents strongly indicated the household transmission of scrub typhus and other rickettsial diseases in the outbreak village.
恙虫病是立克次体病之一，是一种由革兰氏阴性菌恙虫病东方体由感染螨叮咬引起的男性急性发热性疾病。据报告，在印度北部、南部和东部的不同地区暴发了丛林斑疹伤寒。据报告，在朗莱区医院，有两名来自哲尔村的不幸死亡病例，他们死于恙虫病。同时，米佐拉姆邦朗莱县Cheural村居民的卫生官员也报告了多例有恙虫病等症状的病例。在242人的检测中，80人(33.05%)对Weil felix PROGEN OXK呈1:160滴度反应。在20-60岁的工作年龄组中观察到的病例最多。在不同的职业群体中，农民受影响最大，超过90%的村民从事林场耕作。对捕获的5只啮齿动物的血清也进行了Weil felix测试。所有捕获的鼠血清对一种或多种抗原均有反应。啮齿动物标本中检出恙螨，恙螨指数为19.2。研究表明，恙虫病和其他立克次体病是此次暴发的主要原因。恙螨指数和恙螨与捕获鼠血清的反应率极高，表明恙虫病和其他立克次体疾病在暴发村存在家庭传播。
{"title":"SCRUB TYPHUS DISEASE OUTBREAK AT CHEURAL VILLAGE, LAWNGTLAI DISTRICT, MIZORAM, NORTH-EAST INDIA","authors":"Lalfakzuala Pautu, Pachuau Lalmalsawma, Vanramliana ., G. Rosangkima, Yogesh Malvi, Hunropuia .","doi":"10.55218/jasr.202213902","DOIUrl":"https://doi.org/10.55218/jasr.202213902","url":null,"abstract":"Scrub typhus, which is one of the rickettsial diseases, is an acute, febrile illness in men caused by the pathogen, 18 a gram-negative bacterium Orientia tsutsugamushi from the bite of infected mite. Outbreaks of scrub typhus have been reported from various parts of North, South, and Eastern India. There was a report of two unfortunate death cases from Cheural village due to scrub typhus at Lawngtlai district hospital. While, multiple cases, having symptoms like scrub typhus illness were also reported by health officials of the residents of Cheural village, Lawngtlai District, Mizoram. Among the 242 person tested, 80 (33.05%) person were found reactive with Weil felix PROGEN OXK at 1:160 titre value. Maximum numbers of cases were observed among the working age group 20-60 years. Among the different occupational groups, farmers were the most affected as more than 90% of the villagers were involved in forest farming. The five captured rodents’ sera were also tested with Weil felix. All of the captured rodent sera were reactive with one or more antigen. Mites (chigger) were also collected from the rodent samples and the chigger index was found to be 19.2. This study indicated that scrub typhus and other rickettsial diseases were responsible for the outbreak. The extremely high chigger index with reactivity rate reactivity rate of Weil felix with sera of captured rodents strongly indicated the household transmission of scrub typhus and other rickettsial diseases in the outbreak village.","PeriodicalId":14906,"journal":{"name":"Journal of Advanced Scientific Research","volume":"97 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82815998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The present investigation is concerned with a method by the reaction of vanadylsulphate with nitrogen containing ligands N, N donor sites like dicyandiamide, methyldicyandiamide and phenyldicyandiamide in methanol and refluxed. The tentative structure of these complexes has been proposed on the basis of elemental analysis, magnetic moment and spectral (IR, EPR) data. The IR and EPR spectra of all the complexes were recorded at room temperature and at liquid nitrogen temperature. The room temperature EPR spectrum shows anisotropy because the band is observed separately.
{"title":"SYNTHESIS AND SPECTROSCOPIC STUDIES ON OXOVANADIUM COMPLEX WITH LIGANDS HAVING N, N-DONOR SITES","authors":"Y. Singh, R. Jha","doi":"10.55218/jasr.202213805","DOIUrl":"https://doi.org/10.55218/jasr.202213805","url":null,"abstract":"The present investigation is concerned with a method by the reaction of vanadylsulphate with nitrogen containing ligands N, N donor sites like dicyandiamide, methyldicyandiamide and phenyldicyandiamide in methanol and refluxed. The tentative structure of these complexes has been proposed on the basis of elemental analysis, magnetic moment and spectral (IR, EPR) data. The IR and EPR spectra of all the complexes were recorded at room temperature and at liquid nitrogen temperature. The room temperature EPR spectrum shows anisotropy because the band is observed separately.","PeriodicalId":14906,"journal":{"name":"Journal of Advanced Scientific Research","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79793491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Antimicrobial drugs have caused a dramatic change not only of the treatment of infectious diseases but of the mankind as a whole. Antimicrobial chemotherapy made remarkable advances, However, in reality emerging and re-emerging infectious diseases have left us facing a counter charge from infections. Infections with drug resistant organisms remain pertinent problem in clinical practice that is difficult to solv. (In the present study, the antimicrobial activity of the polar (methanolic) plant extracts viz. Polygonatum cirrhifolium (Mahamedha) and Habeneria intermedia (Riddhi) were determined at 200μg/ml. The results showed significant antimicrobial activity against the pathogens studied viz. Staphylococcus epidermidis, Aspergillus niger and Candida albicans. The potent antimicrobial extracts were having MIC values in the range of 150-200 μg/ml.
{"title":"ANTIMICROBIAL ACTIVITY OF SOLVENT EXTRACTS OF POLYGONATUM CIRRHIFOLIUM (MAHAMEDHA) AND HABENERIA INTERMEDIA (RIDDHI)","authors":"Reetu Sharma, Ranjit Singh","doi":"10.55218/jasr.202213806","DOIUrl":"https://doi.org/10.55218/jasr.202213806","url":null,"abstract":"Antimicrobial drugs have caused a dramatic change not only of the treatment of infectious diseases but of the mankind as a whole. Antimicrobial chemotherapy made remarkable advances, However, in reality emerging and re-emerging infectious diseases have left us facing a counter charge from infections. Infections with drug resistant organisms remain pertinent problem in clinical practice that is difficult to solv. (In the present study, the antimicrobial activity of the polar (methanolic) plant extracts viz. Polygonatum cirrhifolium (Mahamedha) and Habeneria intermedia (Riddhi) were determined at 200μg/ml. The results showed significant antimicrobial activity against the pathogens studied viz. Staphylococcus epidermidis, Aspergillus niger and Candida albicans. The potent antimicrobial extracts were having MIC values in the range of 150-200 μg/ml.","PeriodicalId":14906,"journal":{"name":"Journal of Advanced Scientific Research","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81617877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Griseofulvin is a poorly soluble antifungal antibiotic drug, the solubility of which can be enhanced by complexation with β-cyclodextrin. The inclusion complex was prepared by Physical and Kneading method in various molar ratios of 1:1, 1:2 and 2:1 of the drug and β-cyclodextrin, respectively. IR spectra of drug, polymer and a physical mixture of drug and polymer were obtained using FT-IR. The inclusion complex was characterized and evaluated by determination of aqueous solubility, determination of pH stability, estimation of griseofulvin in complexes and stability study. The aqueous solubility of the GCD inclusion complexes was determined using the Higuchi-Connor method. The results indicated that the use of kneading method for preparation of complexes was more effective than the physical mixture method. The inclusion complexes were on the other hand was able to prevent the degradation of griseofulvin at all the pH. The degradation of griseofulvin from the inclusion complexes was found to be prevented and around 20-35% drug degraded in the acidic buffer while 40-50% drug degraded in the neutral and alkaline buffers. It was very much evident from the stability data that the inclusion complexes were helpful in improving the solution stability of griseofulvin. Complex F5 was used as the complex of choice for stability analysis as it exhibited the highest aqueous solubility amongst all the inclusion complexes that were prepared. The results reveal that the kneading method was helpful in incorporating higher amount of griseofulvin in the complex, the inclusion complex of griseofulvin (F5) was subjected to short term accelerated stability testing by storing the complexes at room temperature and at 45ºC. The samples were analyzed at an interval of one week, three weeks and six weeks for their physical appearance and drug content values. No appreciable changes observed with the above parameters.
{"title":"FORMULATING β-CYCLODEXTRIN INCLUSION COMPLEXES FOR SOLUTION STABILITY ENHANCEMENT OF GRISEOFULVIN","authors":"Anjali Sahu, Khushi Chouksey, K. Ganju","doi":"10.55218/jasr.202213810","DOIUrl":"https://doi.org/10.55218/jasr.202213810","url":null,"abstract":"Griseofulvin is a poorly soluble antifungal antibiotic drug, the solubility of which can be enhanced by complexation with β-cyclodextrin. The inclusion complex was prepared by Physical and Kneading method in various molar ratios of 1:1, 1:2 and 2:1 of the drug and β-cyclodextrin, respectively. IR spectra of drug, polymer and a physical mixture of drug and polymer were obtained using FT-IR. The inclusion complex was characterized and evaluated by determination of aqueous solubility, determination of pH stability, estimation of griseofulvin in complexes and stability study. The aqueous solubility of the GCD inclusion complexes was determined using the Higuchi-Connor method. The results indicated that the use of kneading method for preparation of complexes was more effective than the physical mixture method. The inclusion complexes were on the other hand was able to prevent the degradation of griseofulvin at all the pH. The degradation of griseofulvin from the inclusion complexes was found to be prevented and around 20-35% drug degraded in the acidic buffer while 40-50% drug degraded in the neutral and alkaline buffers. It was very much evident from the stability data that the inclusion complexes were helpful in improving the solution stability of griseofulvin. Complex F5 was used as the complex of choice for stability analysis as it exhibited the highest aqueous solubility amongst all the inclusion complexes that were prepared. The results reveal that the kneading method was helpful in incorporating higher amount of griseofulvin in the complex, the inclusion complex of griseofulvin (F5) was subjected to short term accelerated stability testing by storing the complexes at room temperature and at 45ºC. The samples were analyzed at an interval of one week, three weeks and six weeks for their physical appearance and drug content values. No appreciable changes observed with the above parameters.","PeriodicalId":14906,"journal":{"name":"Journal of Advanced Scientific Research","volume":"42 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88492617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Geetha Karra, R. Kiran, Shirisha Mardanapall, T. Rao
The aim of this review is to provide information regarding significant aspects and challenges in developing of nasal sprays. This article outlined the relevant aspects of nasal anatomy, physiology & biological, physicochemical and pharmaceutical factors that must be considered during formulation development of nasal sprays. Nasal drug delivery system is the most preferable route than other routes of administration as it gives rapid onset of action. It is considered as a convenient and reliable route for local and also for systemic administration of drugs. The main highlights of this review includes types, advantages, disadvantages, mechanisms of drug absorption, factors of nasal drug absorption, formulation, methods of manufacturing and filling of nasal sprays, evaluation, characterization and applications.
{"title":"A REVIEW ON CHALLENGES IN DEVELOPING NASAL SPRAYS","authors":"Geetha Karra, R. Kiran, Shirisha Mardanapall, T. Rao","doi":"10.55218/jasr.202213802","DOIUrl":"https://doi.org/10.55218/jasr.202213802","url":null,"abstract":"The aim of this review is to provide information regarding significant aspects and challenges in developing of nasal sprays. This article outlined the relevant aspects of nasal anatomy, physiology & biological, physicochemical and pharmaceutical factors that must be considered during formulation development of nasal sprays. Nasal drug delivery system is the most preferable route than other routes of administration as it gives rapid onset of action. It is considered as a convenient and reliable route for local and also for systemic administration of drugs. The main highlights of this review includes types, advantages, disadvantages, mechanisms of drug absorption, factors of nasal drug absorption, formulation, methods of manufacturing and filling of nasal sprays, evaluation, characterization and applications.","PeriodicalId":14906,"journal":{"name":"Journal of Advanced Scientific Research","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90575433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
An eco-friendly green strategy is presented for the synthesis of Ag-Ni hybrid nanoparticles taking a medicinal plant, Aerva lanata for phytoreduction of the precursor salt solutions. The synthesized nanoparticles are characterized by instrumental techniques such as UV-Visible, FTIR, EDX, FESEM and HRTEM. These particles are found to possess significant antibacterial efficacy against both Gram-positive and Gram-negative bacteria based on investigation by Well Diffusion method.
{"title":"STUDY OF ANTIBACTERIAL EFFICACY OF GREEN -SYNTHESIZED SILVER-NICKEL HYBRID NANOPARTICLES","authors":"Ch S Anuradha, S. Padmavathi","doi":"10.55218/jasr.202213807","DOIUrl":"https://doi.org/10.55218/jasr.202213807","url":null,"abstract":"An eco-friendly green strategy is presented for the synthesis of Ag-Ni hybrid nanoparticles taking a medicinal plant, Aerva lanata for phytoreduction of the precursor salt solutions. The synthesized nanoparticles are characterized by instrumental techniques such as UV-Visible, FTIR, EDX, FESEM and HRTEM. These particles are found to possess significant antibacterial efficacy against both Gram-positive and Gram-negative bacteria based on investigation by Well Diffusion method.","PeriodicalId":14906,"journal":{"name":"Journal of Advanced Scientific Research","volume":"158 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78067749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nursery experiments were conducted to select the suitable biofertilizers combination to attain quality seedlings of Neem. The biofertilizers such as Azospirillum, Paenibacillus and AM fungus (Glomus fasciculatum) were inoculated by separately and various combinations with each other at time of seed sowing. Shoot length, root length, collar diameter, and shoot and root dry weight were recorded on 80 days after treatment. Results showed that the total length of seedlings and biomass were significantly increased in the seedlings treated with combined inoculation of Azospirillum + Paenibacillus + AM fungus when compared to control. Among the individual inoculation, Paenibacillus (T1) showed better response than other individual inoculation. Within double inoculations, Azospirillum + Paenibacillus (T4) was superior when compared with other double inoculations. In general Azospirillum and its combination with other biofertilizers had more root length and biomass than other treatments.
{"title":"BIOFORMULATION FOR THE QUALITY SEEDLING PRODUCTION OF AZADIRACHTA INDICA A. JUSS. IN TROPICAL NURSERY CONDITIONS","authors":"J. Gunasundari, K. Rajendran","doi":"10.55218/jasr.202213815","DOIUrl":"https://doi.org/10.55218/jasr.202213815","url":null,"abstract":"Nursery experiments were conducted to select the suitable biofertilizers combination to attain quality seedlings of Neem. The biofertilizers such as Azospirillum, Paenibacillus and AM fungus (Glomus fasciculatum) were inoculated by separately and various combinations with each other at time of seed sowing. Shoot length, root length, collar diameter, and shoot and root dry weight were recorded on 80 days after treatment. Results showed that the total length of seedlings and biomass were significantly increased in the seedlings treated with combined inoculation of Azospirillum + Paenibacillus + AM fungus when compared to control. Among the individual inoculation, Paenibacillus (T1) showed better response than other individual inoculation. Within double inoculations, Azospirillum + Paenibacillus (T4) was superior when compared with other double inoculations. In general Azospirillum and its combination with other biofertilizers had more root length and biomass than other treatments.","PeriodicalId":14906,"journal":{"name":"Journal of Advanced Scientific Research","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72725670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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