Pub Date : 2023-03-31DOI: 10.55218/jasr.2023140309
H. Wala, Shailendra Sharma, Rekha Sharma
Dilawara reservoir of Dhar, Madhya Pradesh, India; an important drinking water source of Dhar tehsil is also widely used for fishculture besides irrigation and domestic purpose. In the present study, the demersal fish fauna of Dilawara Reservoir were selected for the gut content study and included species of catfish (Heteropneustes fossilis and Clarias batrachus), minor carps (Rasbora daniconius, Danio melaharicus, Puntisticto, P. sarana): fingerlings of major and common carp, snake head (Channa striatus, C. punctatus), one species of clupeide (Gadusia chapra) and one species of Mastocembalidae (Mastucembalus armatus). The selection of fish species was made on their feeding habits and their availability throughout the year. The food of demersal fish species of Dilawara Reservoir varied and diversified to include, mollusks, crustaceans, annelids, insects, snails, fish, macrophytes and various algae. Gut content analysis showed that most of the fish species preyed on zooplankton benthic animals except for fishes belonging to Family Clupeidae (Gudusia chapra) and minor carps. Their Stomach content analysis showed that macrophytes and algae were exclusively the dominant food items observed in their stomachs and were categorized as omnivorous
{"title":"FISH GUT ANALYSIS OF DEMERSAL FISH SPECIES OF DILAWARA RESERVOIR OF DHAR TEHSIL OF DHAR DISTRICT, MADHYA PRADESH","authors":"H. Wala, Shailendra Sharma, Rekha Sharma","doi":"10.55218/jasr.2023140309","DOIUrl":"https://doi.org/10.55218/jasr.2023140309","url":null,"abstract":"Dilawara reservoir of Dhar, Madhya Pradesh, India; an important drinking water source of Dhar tehsil is also widely used for fishculture besides irrigation and domestic purpose. In the present study, the demersal fish fauna of Dilawara Reservoir were selected for the gut content study and included species of catfish (Heteropneustes fossilis and Clarias batrachus), minor carps (Rasbora daniconius, Danio melaharicus, Puntisticto, P. sarana): fingerlings of major and common carp, snake head (Channa striatus, C. punctatus), one species of clupeide (Gadusia chapra) and one species of Mastocembalidae (Mastucembalus armatus). The selection of fish species was made on their feeding habits and their availability throughout the year. The food of demersal fish species of Dilawara Reservoir varied and diversified to include, mollusks, crustaceans, annelids, insects, snails, fish, macrophytes and various algae. Gut content analysis showed that most of the fish species preyed on zooplankton benthic animals except for fishes belonging to Family Clupeidae (Gudusia chapra) and minor carps. Their Stomach content analysis showed that macrophytes and algae were exclusively the dominant food items observed in their stomachs and were categorized as omnivorous","PeriodicalId":14906,"journal":{"name":"Journal of Advanced Scientific Research","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73069733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-31DOI: 10.55218/jasr.2023140302
Savitha Ku, Kavitha Al, R. M
Textiles are having evolution from being normal protective clothing to smart and technical textiles. Electrically conducting fabrics forms the backbone of being smart textiles. The smart textile combines electronics with textile structures, referred to as “textronics”. One major challenge to the success of such wearable smart textile resides in the development of lightweight and flexible components, and fibrous structures with high electrical conductivity able to withstand the stresses associated with wearing and caring for the textile. Therefore, flexible, deformable, stretchable, and durable conductive textile materials are needed for durable smart fabrics that capture and convey information and enable computing while accommodating the drape and movement of the human body. In recent decades, numerous approaches have been made in research to address this challenge using the flexibility and versatility of textile structures, along with innovations in the field of particulate and fibrous materials. This review focuses on the methods of synthesis of electrically conducting textiles and their applications. Particularly, it summarizes textile based multi-functional devices and their potential applications for portable or wearable functional integrated electronics, energy conversion & storage devices, sensors and actuators. The methods of fabrication like incorporation of conducting polymers are briefly discussed.
{"title":"AN OVERVIEW OF ELECTRICALLY CONDUCTING TEXTILES","authors":"Savitha Ku, Kavitha Al, R. M","doi":"10.55218/jasr.2023140302","DOIUrl":"https://doi.org/10.55218/jasr.2023140302","url":null,"abstract":"Textiles are having evolution from being normal protective clothing to smart and technical textiles. Electrically conducting fabrics forms the backbone of being smart textiles. The smart textile combines electronics with textile structures, referred to as “textronics”. One major challenge to the success of such wearable smart textile resides in the development of lightweight and flexible components, and fibrous structures with high electrical conductivity able to withstand the stresses associated with wearing and caring for the textile. Therefore, flexible, deformable, stretchable, and durable conductive textile materials are needed for durable smart fabrics that capture and convey information and enable computing while accommodating the drape and movement of the human body. In recent decades, numerous approaches have been made in research to address this challenge using the flexibility and versatility of textile structures, along with innovations in the field of particulate and fibrous materials. This review focuses on the methods of synthesis of electrically conducting textiles and their applications. Particularly, it summarizes textile based multi-functional devices and their potential applications for portable or wearable functional integrated electronics, energy conversion & storage devices, sensors and actuators. The methods of fabrication like incorporation of conducting polymers are briefly discussed.","PeriodicalId":14906,"journal":{"name":"Journal of Advanced Scientific Research","volume":"33 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84529339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-31DOI: 10.55218/jasr.2023140305
Baljeet Kaur, A. Saxena, Kirti Roy, M. Bhardwaj, M. Bisht
Herbal medications have a diverse range of active constituents allowing us to use them in a variety of ways, but active constituents are poorly absorbed due to their strong polarity and low lipophilicity, resulting in low bioavailability. The aim of this research was to improve bioavailability by development and in-vitro evaluation of phytosomes containing herbal extract of Centella asiatica for its antioxidant and gastroprotective activity. Phytosomes of Centella asiatica were prepared by reflex method and further it is characterized and evaluated. The complex formation was estimated by FTIR analysis and drug content and drug entrapment efficiency of phytosomes was achieved to be 91.6% and 84.3% respectively. The mean diameter was found to be 854.2 nm and zeta potential 28.4 mV was found. It indicates that the in-vitro drug release of Centella asiatica were higher in comparison to the formulation complex i.e., 100% and 77.6%. The release kinetics of the optimized phytosomal formulation (F3) best fitted and the R2 value was found to be 0.9879. The anti-oxidant activity of Centella asiatica phytosomes was superior than its hydroalcoholic extract i.e., % inhibition of phytosomal formulation is 83.55 having IC50 value 1.99 and % inhibition of hydroalcoholic drug extract was 85.31 having IC50 value 2.77. In anti-ulcer activity phytosomes was found to neutralize acid more significant as compare to standard and hydroalcoholic extract of Centella asiatica. The results indicated that the prepared phytosome could be a promising candidate for effective delivery of active constituents.
{"title":"DEVELOPMENT AND IN-VITRO EVALUATION OF PHYTOSOMES CONTAINING HERBAL EXTRACT OF CENTELLA ASIATICA FOR ANTIULCER AND ANTIOXIDANT ACTIVITY","authors":"Baljeet Kaur, A. Saxena, Kirti Roy, M. Bhardwaj, M. Bisht","doi":"10.55218/jasr.2023140305","DOIUrl":"https://doi.org/10.55218/jasr.2023140305","url":null,"abstract":"Herbal medications have a diverse range of active constituents allowing us to use them in a variety of ways, but active constituents are poorly absorbed due to their strong polarity and low lipophilicity, resulting in low bioavailability. The aim of this research was to improve bioavailability by development and in-vitro evaluation of phytosomes containing herbal extract of Centella asiatica for its antioxidant and gastroprotective activity. Phytosomes of Centella asiatica were prepared by reflex method and further it is characterized and evaluated. The complex formation was estimated by FTIR analysis and drug content and drug entrapment efficiency of phytosomes was achieved to be 91.6% and 84.3% respectively. The mean diameter was found to be 854.2 nm and zeta potential 28.4 mV was found. It indicates that the in-vitro drug release of Centella asiatica were higher in comparison to the formulation complex i.e., 100% and 77.6%. The release kinetics of the optimized phytosomal formulation (F3) best fitted and the R2 value was found to be 0.9879. The anti-oxidant activity of Centella asiatica phytosomes was superior than its hydroalcoholic extract i.e., % inhibition of phytosomal formulation is 83.55 having IC50 value 1.99 and % inhibition of hydroalcoholic drug extract was 85.31 having IC50 value 2.77. In anti-ulcer activity phytosomes was found to neutralize acid more significant as compare to standard and hydroalcoholic extract of Centella asiatica. The results indicated that the prepared phytosome could be a promising candidate for effective delivery of active constituents.","PeriodicalId":14906,"journal":{"name":"Journal of Advanced Scientific Research","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89802833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-31DOI: 10.55218/jasr.2023140308
R. ., PoonRakesh Roushanam
Autonomic nervous system (ANS) is a centre for the coordination of different body systems. Since the ANS is involved in energy metabolism and in the regulation of almost all visceral systems. It is conceivable that one or more subgroups of persons with idiopathic obesity have an alteration in their autonomic nervous system that may account for several clinical consequences of obesity. This observational study was conducted to find the association of Autonomic Function Tests among obese and non-obese participants. Among 90 participants, 45 were obese and 45 were non-obese, aged 18-40 years of either gender was enrolled after getting their voluntary written consent. In both the groups, Cold Pressure Test and Hand Grip Test were performed for evaluating sympathetic functions. Standing test (30:15 RR Ratio), Standing to Lying ratio, and Valsalva ratio were performed for evaluating parasympathetic functions. Chi-square and unpaired t test was employed for statistical analysis. A statistically significant association of Autonomic Function Tests among obese and non-obese participants was found as per BMI and Body Fat Percentage criteria. Study explored that obesity was associated with ANS dysfunction as compared to non-obese; this relationship was observed primarily in terms of sympathetic and parasympathetic activity. The results of this study are indicative of autonomic insufficiency among obese participants.
{"title":"EVALUATION OF CARDIOVASCULAR AUTONOMIC FUNCTION TESTS IN OBESE AND NON-OBESE HEALTHY INDIANS","authors":"R. ., PoonRakesh Roushanam","doi":"10.55218/jasr.2023140308","DOIUrl":"https://doi.org/10.55218/jasr.2023140308","url":null,"abstract":"Autonomic nervous system (ANS) is a centre for the coordination of different body systems. Since the ANS is involved in energy metabolism and in the regulation of almost all visceral systems. It is conceivable that one or more subgroups of persons with idiopathic obesity have an alteration in their autonomic nervous system that may account for several clinical consequences of obesity. This observational study was conducted to find the association of Autonomic Function Tests among obese and non-obese participants. Among 90 participants, 45 were obese and 45 were non-obese, aged 18-40 years of either gender was enrolled after getting their voluntary written consent. In both the groups, Cold Pressure Test and Hand Grip Test were performed for evaluating sympathetic functions. Standing test (30:15 RR Ratio), Standing to Lying ratio, and Valsalva ratio were performed for evaluating parasympathetic functions. Chi-square and unpaired t test was employed for statistical analysis. A statistically significant association of Autonomic Function Tests among obese and non-obese participants was found as per BMI and Body Fat Percentage criteria. Study explored that obesity was associated with ANS dysfunction as compared to non-obese; this relationship was observed primarily in terms of sympathetic and parasympathetic activity. The results of this study are indicative of autonomic insufficiency among obese participants.","PeriodicalId":14906,"journal":{"name":"Journal of Advanced Scientific Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75554579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-31DOI: 10.55218/jasr.2023140304
P. Mourya, Dheerendra Singh, G. Rai, R. Shukla
Diabetes mellitus (DM) is a metabolic disorder, occur when the pancreas does not make sufficient amount of insulin. Hyperglycaemia leads to severe injure especially the nerves and blood vessels (retinopathy, neuropathy, and nephropathy). According to World Health Organization the diabetic people is expected to increase up to 300 million or more by the year 2025. We searched the scientific database using various original research articles, clinical trials, meta analysis, patent reports, validation study, observational study, review articles published in PubMed, Scopus, Science direct and Google by using the keyword. After an initial search, 528 articles were identified, out of which 50 articles had required criteria for the comparative study and meta-analysis of related topics. Herbal plants were extremely venerated source of medicine in Ayurveda and now they have become a growing part of modern, high-tech medicine. It also reveals the information about the most recent innovation in the treatment of Type-I and Type II Diabetes mellitus. These reviews have proven that the herbal drugs were used for the treatment of Type II Diabetes mellitus worldwide. It also reveals that new approaches of nanotechnology were good choice for the management of Diabetes mellitus now a days. Hopefully, these new kind of treatment may help in making the everyday lives of millions of diabetes patients more comfortable.
{"title":"A REVIEW OF HERBAL DRUGS AND PROSPECTIVE STUDIES FOR MANAGEMENT OF DIABETES MELLITUS","authors":"P. Mourya, Dheerendra Singh, G. Rai, R. Shukla","doi":"10.55218/jasr.2023140304","DOIUrl":"https://doi.org/10.55218/jasr.2023140304","url":null,"abstract":"Diabetes mellitus (DM) is a metabolic disorder, occur when the pancreas does not make sufficient amount of insulin. Hyperglycaemia leads to severe injure especially the nerves and blood vessels (retinopathy, neuropathy, and nephropathy). According to World Health Organization the diabetic people is expected to increase up to 300 million or more by the year 2025. We searched the scientific database using various original research articles, clinical trials, meta analysis, patent reports, validation study, observational study, review articles published in PubMed, Scopus, Science direct and Google by using the keyword. After an initial search, 528 articles were identified, out of which 50 articles had required criteria for the comparative study and meta-analysis of related topics. Herbal plants were extremely venerated source of medicine in Ayurveda and now they have become a growing part of modern, high-tech medicine. It also reveals the information about the most recent innovation in the treatment of Type-I and Type II Diabetes mellitus. These reviews have proven that the herbal drugs were used for the treatment of Type II Diabetes mellitus worldwide. It also reveals that new approaches of nanotechnology were good choice for the management of Diabetes mellitus now a days. Hopefully, these new kind of treatment may help in making the everyday lives of millions of diabetes patients more comfortable.","PeriodicalId":14906,"journal":{"name":"Journal of Advanced Scientific Research","volume":"61 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88786948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pathogens in public areas e.g. public transport system can be a critical public health issue due to ease of transfer. Present study deals with isolation and characterization of pathogenic bacteria from touch surfaces of railway station premises. A total of 53 swab samples taken from different touch surfaces were processed by classical microbiological procedures. Isolates were subjected to antibiotic sensitivity test. Further modified disinfectant challenge test was used to compare effectiveness of four commonly used disinfectants. Overall total 73 isolates were obtained. After morphological, cultural and biochemical analysis 7 isolates were identified as Methicillin resistant Staphylococcus aureus (MRSA) and 6 isolates as extended spectrum β-lactamase producing (ESBL) Escherichia coli. By virtue, these all were multidrug resistant. A disinfectant challenge test revealed Sodium hypochlorite, Dettol, MEDNTEK - R82 were effective while Santavis, a locally available disinfectant cum floor cleaner was not effective at recommended dilutions. Presence of multi drug resistant pathogenic bacteria in premises of railway station is extremely worrisome finding. Appropriate cleaning and disinfection measures required to prevent dissemination of these pathogens.
{"title":"CHARACTERIZATION OF DRUG RESISTANT BACTERIA ISOLATED FROM SUBURBAN RAILWAY STATION PREMISES","authors":"Omkar Lele, Nishad Supugade, Nupur Gholap, Rohin Patil","doi":"10.55218/jasr.2023140306","DOIUrl":"https://doi.org/10.55218/jasr.2023140306","url":null,"abstract":"Pathogens in public areas e.g. public transport system can be a critical public health issue due to ease of transfer. Present study deals with isolation and characterization of pathogenic bacteria from touch surfaces of railway station premises. A total of 53 swab samples taken from different touch surfaces were processed by classical microbiological procedures. Isolates were subjected to antibiotic sensitivity test. Further modified disinfectant challenge test was used to compare effectiveness of four commonly used disinfectants. Overall total 73 isolates were obtained. After morphological, cultural and biochemical analysis 7 isolates were identified as Methicillin resistant Staphylococcus aureus (MRSA) and 6 isolates as extended spectrum β-lactamase producing (ESBL) Escherichia coli. By virtue, these all were multidrug resistant. A disinfectant challenge test revealed Sodium hypochlorite, Dettol, MEDNTEK - R82 were effective while Santavis, a locally available disinfectant cum floor cleaner was not effective at recommended dilutions. Presence of multi drug resistant pathogenic bacteria in premises of railway station is extremely worrisome finding. Appropriate cleaning and disinfection measures required to prevent dissemination of these pathogens.","PeriodicalId":14906,"journal":{"name":"Journal of Advanced Scientific Research","volume":"66 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77741158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-03-31DOI: 10.55218/jasr.2023140303
Pankaja Umarane, R. Nerli, Rangrez Shadab
Genetic alterations are one of the important known risk factors of prostate cancer. The family predisposition of breast and ovarian cancers may cause the severe progression of familial prostate cancer in some men. The association of germline mutations in BRCA1 and BRCA2 genes can cause breast cancer in almost 35% of women and 9% of men. Carriers of these pathogenic variants have a higher risk of causing prostate cancer. This study focused on the analysis of mutations causing prostate cancer around the world, associated with breast cancer susceptibility genes
{"title":"ASSOCIATION OF FAMILIAL PROSTATE CANCER WITH BREAST CANCER SUSCEPTIBILITY GENE MUTATIONS","authors":"Pankaja Umarane, R. Nerli, Rangrez Shadab","doi":"10.55218/jasr.2023140303","DOIUrl":"https://doi.org/10.55218/jasr.2023140303","url":null,"abstract":"Genetic alterations are one of the important known risk factors of prostate cancer. The family predisposition of breast and ovarian cancers may cause the severe progression of familial prostate cancer in some men. The association of germline mutations in BRCA1 and BRCA2 genes can cause breast cancer in almost 35% of women and 9% of men. Carriers of these pathogenic variants have a higher risk of causing prostate cancer. This study focused on the analysis of mutations causing prostate cancer around the world, associated with breast cancer susceptibility genes","PeriodicalId":14906,"journal":{"name":"Journal of Advanced Scientific Research","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84072243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Drug distribution and absorption are significantly influenced by the biological membrane's permeability. Since aspirin requires high and frequent doses and undergoes substantial presystemic metabolism during oral absorption, there is a higher risk of GIT adverse effects. The purpose of the current study was to use the everted sac technique on goat intestine to examine the impact of orange peel (Citrus Aurantium Dulcis) extract on intestinal absorption. When kept with orange peel extract, the concentration of absorbed aspirin was 20, 26, 30, 38, and 50μg/ml after 15, 30, 45, 60, and 75 minutes, compared to 14, 16, 17, 18 and 23 μg/ml when kept alone. According to the study, aspirin is absorbed more readily from goat intestines when orange peel extract is used. Citrus peel contains a lot of phenolic chemicals, including flavonoids and phenolic acids. In addition, limonene, citral, neohesperidin, naringin, rutin, rhamnose, eriocitrin, and Vitamin-C etc. are found in the peel. They might be in charge of the plant's capacity to boost absorption.
{"title":"EFFECT OF ORANGE PEEL EXTRACT ON INTESTINAL ABSORPTION OF ASPIRIN USING EVERTED SAC TECHNIQUE","authors":"Komal Dattatray Pol, P. Jagtap, Sumit Kailas Musle, Shweta Shivaling Bobade, Ankita Mahadeo Kadam, Vaishnavi Pradeep More, Pratibha Pradip Deshmukh, A. Kunjir","doi":"10.55218/jasr.2023140307","DOIUrl":"https://doi.org/10.55218/jasr.2023140307","url":null,"abstract":"Drug distribution and absorption are significantly influenced by the biological membrane's permeability. Since aspirin requires high and frequent doses and undergoes substantial presystemic metabolism during oral absorption, there is a higher risk of GIT adverse effects. The purpose of the current study was to use the everted sac technique on goat intestine to examine the impact of orange peel (Citrus Aurantium Dulcis) extract on intestinal absorption. When kept with orange peel extract, the concentration of absorbed aspirin was 20, 26, 30, 38, and 50μg/ml after 15, 30, 45, 60, and 75 minutes, compared to 14, 16, 17, 18 and 23 μg/ml when kept alone. According to the study, aspirin is absorbed more readily from goat intestines when orange peel extract is used. Citrus peel contains a lot of phenolic chemicals, including flavonoids and phenolic acids. In addition, limonene, citral, neohesperidin, naringin, rutin, rhamnose, eriocitrin, and Vitamin-C etc. are found in the peel. They might be in charge of the plant's capacity to boost absorption.","PeriodicalId":14906,"journal":{"name":"Journal of Advanced Scientific Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76534484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-31DOI: 10.55218/jasr.2022131104
S. Das, Arpita Maitra, M. Pal, R. Paul
After the first observations of life under the microscope, it took almost two centuries of research before the idea that all living things are composed of cells or their products was speculated. The development of the microscope was a requirement for the discovery of cells. In 1673, the Dutch botanist, Anton van Leeuwenhoek, reported seeing a myriad of microscopic "animalcules" in water. Over several decades, knowledge about the structure and functions of the cell has progressed tremendously due to the advancement in various techniques like next generation sequencing, and genome wide analysis. Cancers are generated from normal cells by random karyotypic rearrangements. Immortality is a common characteristic of cancers, but its origin and purpose are still unclear. Since such rearrangements disturb long-established mitosis genes, cancer karyotypes vary instinctively but are stabilized perpetually by clonal selections for autonomy. The differentiation stage of tumors is a vital aspect in the histopathological classification of solid malignancies, strongly associated with tumor behavior, as an immature tumor is more aggressive than the more differentiated counterpart. The central focus in these events is the cell that undergoes a series of morphological and biochemical changes in course of its transition from normal to a transformed tumor cell; thus acquiring typical characteristics which aids in the process of progression. In this review an attempt has been made to enlighten upon the unusual behavior of a normal cell in transition.
在第一次在显微镜下观察生命之后，经过近两个世纪的研究，人们才推测出所有生物都是由细胞或细胞产物组成的。显微镜的发展是发现细胞的必要条件。1673年，荷兰植物学家安东·范·列文虎克(Anton van Leeuwenhoek)报告说，他在水中看到了无数微小的“微生物”。几十年来，由于下一代测序和全基因组分析等各种技术的进步，关于细胞结构和功能的知识取得了巨大进展。癌症是由正常细胞通过随机核型重排产生的。长生不老是癌症的共同特征，但其起源和目的尚不清楚。由于这种重排扰乱了长期存在的有丝分裂基因，癌症核型本能地变化，但通过克隆选择的自主性永久稳定下来。肿瘤的分化阶段是实体恶性肿瘤组织病理学分类的一个重要方面，与肿瘤行为密切相关，因为未成熟的肿瘤比分化程度较高的肿瘤更具侵袭性。这些事件的中心焦点是细胞在从正常细胞转变为转化肿瘤细胞的过程中经历了一系列形态和生化变化;这样就获得了有助于进步的典型特征。在这篇综述中，试图揭示正常细胞在转化过程中的不寻常行为。
{"title":"TRANSFORMED CELL - THE UNUSUAL SUCCESSION OF A USUAL CELL","authors":"S. Das, Arpita Maitra, M. Pal, R. Paul","doi":"10.55218/jasr.2022131104","DOIUrl":"https://doi.org/10.55218/jasr.2022131104","url":null,"abstract":"After the first observations of life under the microscope, it took almost two centuries of research before the idea that all living things are composed of cells or their products was speculated. The development of the microscope was a requirement for the discovery of cells. In 1673, the Dutch botanist, Anton van Leeuwenhoek, reported seeing a myriad of microscopic \"animalcules\" in water. Over several decades, knowledge about the structure and functions of the cell has progressed tremendously due to the advancement in various techniques like next generation sequencing, and genome wide analysis. Cancers are generated from normal cells by random karyotypic rearrangements. Immortality is a common characteristic of cancers, but its origin and purpose are still unclear. Since such rearrangements disturb long-established mitosis genes, cancer karyotypes vary instinctively but are stabilized perpetually by clonal selections for autonomy. The differentiation stage of tumors is a vital aspect in the histopathological classification of solid malignancies, strongly associated with tumor behavior, as an immature tumor is more aggressive than the more differentiated counterpart. The central focus in these events is the cell that undergoes a series of morphological and biochemical changes in course of its transition from normal to a transformed tumor cell; thus acquiring typical characteristics which aids in the process of progression. In this review an attempt has been made to enlighten upon the unusual behavior of a normal cell in transition.","PeriodicalId":14906,"journal":{"name":"Journal of Advanced Scientific Research","volume":"70 5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87710724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-12-31DOI: 10.55218/jasr.2022131105
H. B, M. E., Harshavardhini G, Hyma P
Spherical crystallization is a technique in which crystallization and agglomeration are carried out synchronously in one step to form compact spherical form. The most common methods used in spherical agglomeration are quasi emulsion solvent diffusion method, ammonia diffusion system, neutralization technique and co-agglomeration. It succeeded to improve dissolution property of poorly soluble drugs. This can change drug powder properties such as flowability, wettability, packability, compressibility. It has wider applications in improvement of poorly compressible drugs; it has wider application in improvement of compressability of poorly compressible drugs, masking bitter taste of drugs, improving dissolution property, bioavailability and solubility of drugs. Agglomeration crystals converted into tablet forms thus helping us by saving time and reducing cost.
{"title":"SPHERICAL CRYSTALLIZATION: A TOOL TO IMPROVE SOLUBILITY OF DRUGS","authors":"H. B, M. E., Harshavardhini G, Hyma P","doi":"10.55218/jasr.2022131105","DOIUrl":"https://doi.org/10.55218/jasr.2022131105","url":null,"abstract":"Spherical crystallization is a technique in which crystallization and agglomeration are carried out synchronously in one step to form compact spherical form. The most common methods used in spherical agglomeration are quasi emulsion solvent diffusion method, ammonia diffusion system, neutralization technique and co-agglomeration. It succeeded to improve dissolution property of poorly soluble drugs. This can change drug powder properties such as flowability, wettability, packability, compressibility. It has wider applications in improvement of poorly compressible drugs; it has wider application in improvement of compressability of poorly compressible drugs, masking bitter taste of drugs, improving dissolution property, bioavailability and solubility of drugs. Agglomeration crystals converted into tablet forms thus helping us by saving time and reducing cost.","PeriodicalId":14906,"journal":{"name":"Journal of Advanced Scientific Research","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74889839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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