G. Sowparnika, Harikrishnan K K Prasad, M. Thirumarimurugan
The major constraint in automatic control of anaesthesia is patient’s variability based on drug tolerance. A controller has to be designed in such way that it is robust to the actual patient’s response even if the controller is designed based on a nominal patient model. Anaesthetic agent used in this study is isoflurane gas and the controlled delivery of anaesthetic agent has to be given with utmost care of great accuracy because the agents used here have narrow therapeutic uses. The importance of the robustness of the controller to be designed is that it must provide a sufficient and controlled administration of drugs to avoid the situations of under and over dosing of patients. The hemodynamic parameters that are to be measured during drug administration is Mean Arterial Pressure (MAP) and heart rate (HR), whereas another parameter to be measured during anaesthesia delivery is measure of unconsciousness of the patient called asBi-spectral Index (BIS). In this study, the anaesthesia control system is modeled and controller design is made for patient undergoing Intensive Care Treatment (ICU) after valve replacement surgery. The background analysis is made by observing the realtimeparameters such as BIS, MAP, and HR of patient undergone valve replacement surgery.
{"title":"MODELING AND CONTROL OF ANAESTHETICS DURING POST SURGICAL TREATMENT","authors":"G. Sowparnika, Harikrishnan K K Prasad, M. Thirumarimurugan","doi":"10.55218/jasr.202314804","DOIUrl":"https://doi.org/10.55218/jasr.202314804","url":null,"abstract":"The major constraint in automatic control of anaesthesia is patient’s variability based on drug tolerance. A controller has to be designed in such way that it is robust to the actual patient’s response even if the controller is designed based on a nominal patient model. Anaesthetic agent used in this study is isoflurane gas and the controlled delivery of anaesthetic agent has to be given with utmost care of great accuracy because the agents used here have narrow therapeutic uses. The importance of the robustness of the controller to be designed is that it must provide a sufficient and controlled administration of drugs to avoid the situations of under and over dosing of patients. The hemodynamic parameters that are to be measured during drug administration is Mean Arterial Pressure (MAP) and heart rate (HR), whereas another parameter to be measured during anaesthesia delivery is measure of unconsciousness of the patient called asBi-spectral Index (BIS). In this study, the anaesthesia control system is modeled and controller design is made for patient undergoing Intensive Care Treatment (ICU) after valve replacement surgery. The background analysis is made by observing the realtimeparameters such as BIS, MAP, and HR of patient undergone valve replacement surgery.","PeriodicalId":14906,"journal":{"name":"Journal of Advanced Scientific Research","volume":"81 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139324470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Probiotics are live microbes that beneficially affect the human and many studies have proved their promising role as safe and natural therapeutics. The isolation of probiotics from indigenous sources may develop a new way to improved probiotic strains with precious medical relevance for human benefits. Hence the aim of the present study is to isolate probiotics from locally available various dairy products (Viz. raw milk of cow and buffalo and traditional homemade curds) and human breast milk and to identify them upto species level. A total of about 80 samples from human breast milk (n=30) and dairy products (n=50) were collected aseptically and screened for the probiotic microflora using standard microbiological methods. The colonies suspected for probiotics were picked up for morphological and biochemical identification which were further confirmed by molecular methods and application of bioinformatics. The preliminary results showed several different microflora viz. Streptococcus, Staphylococcus, Lactobacillus, Diplococcus, etc. About twelve (12) isolates were further confirmed to be of different species belonging to the Genus Lactobacillus. Therefore dairy products and human breast milk are considered as suitable natural sources for probiotic microorganisms especially Lactobacillus spp., which are reported to show beneficial effects in humans.
{"title":"ISOLATION AND IDENTIFICATION OF INDIGENOUS PROBIOTICS FROM DAIRY PRODUCTS AND HUMAN BREAST MILK","authors":"Sumalata G, Shiva Prakash M","doi":"10.55218/jasr.202314806","DOIUrl":"https://doi.org/10.55218/jasr.202314806","url":null,"abstract":"Probiotics are live microbes that beneficially affect the human and many studies have proved their promising role as safe and natural therapeutics. The isolation of probiotics from indigenous sources may develop a new way to improved probiotic strains with precious medical relevance for human benefits. Hence the aim of the present study is to isolate probiotics from locally available various dairy products (Viz. raw milk of cow and buffalo and traditional homemade curds) and human breast milk and to identify them upto species level. A total of about 80 samples from human breast milk (n=30) and dairy products (n=50) were collected aseptically and screened for the probiotic microflora using standard microbiological methods. The colonies suspected for probiotics were picked up for morphological and biochemical identification which were further confirmed by molecular methods and application of bioinformatics. The preliminary results showed several different microflora viz. Streptococcus, Staphylococcus, Lactobacillus, Diplococcus, etc. About twelve (12) isolates were further confirmed to be of different species belonging to the Genus Lactobacillus. Therefore dairy products and human breast milk are considered as suitable natural sources for probiotic microorganisms especially Lactobacillus spp., which are reported to show beneficial effects in humans.","PeriodicalId":14906,"journal":{"name":"Journal of Advanced Scientific Research","volume":"36 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139324863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aakula Anusha, K. Balaji, Asawar Sai Chandana, Bandaripalli Navya Sri, Chandan Kumar K.N.
Hepatitis B is serious liver illness that is brought on by hepatitis B virus. It is classified into two types- acute and chronic hepatitis. Antivirals are the best choice of treatment for Hepatitis-B. Tenofovir (25mg and 300mg) and Entecavir (0.5mg) are currently used medications to control viral replication and suppress viral DNA levels. The study was a single centered, observational study that included 60 chronic hepatitis-B patients. They were split into two groups of patients prescribed with Tenofovir and Entecavir. Our study was conducted on 60 patients out of which 81.66% were found to be males and 18.33% were found to be females. Among them, most of the patients belonged to the age group 41-60 years (51.66%). In 51 patients taking Tenofovir monotherapy, 41 patients (80.40%) were having ≤2000 IU/mL. In 6 patients taking Entecavir monotherapy, 3 patients (50%) were having ≤2000 IU/mL. In 3 patients taking Dual therapy, 2 patients (66.67%) were having ≤2000 IU/mL. Among 60 patients, ADRs were reported in 41 patients (68.33%). Commonly reported ADRs were weakness, headache, dizziness, abdominal pain. These are mild and occasional. 73.40% patients reported ADRs while using Tenofovir and 83.33% patients reported ADRs while using Entecavir. From our study, it was observed that Tenofovir is having good safety and efficacy (80.40%) whereas Entecavir is having 50% efficacy. Tenofovir safety and efficacy is much more when compared to safety and efficacy of Entecavir.
{"title":"AN OBSERVATIONAL STUDY ON CLINICAL SAFETY AND EFFICACY OF ANTIVIRAL MEDICATIONS USED IN CHRONIC HEPATITIS-B VIRUS INFECTION","authors":"Aakula Anusha, K. Balaji, Asawar Sai Chandana, Bandaripalli Navya Sri, Chandan Kumar K.N.","doi":"10.55218/jasr.202314708","DOIUrl":"https://doi.org/10.55218/jasr.202314708","url":null,"abstract":"Hepatitis B is serious liver illness that is brought on by hepatitis B virus. It is classified into two types- acute and chronic hepatitis. Antivirals are the best choice of treatment for Hepatitis-B. Tenofovir (25mg and 300mg) and Entecavir (0.5mg) are currently used medications to control viral replication and suppress viral DNA levels. The study was a single centered, observational study that included 60 chronic hepatitis-B patients. They were split into two groups of patients prescribed with Tenofovir and Entecavir. Our study was conducted on 60 patients out of which 81.66% were found to be males and 18.33% were found to be females. Among them, most of the patients belonged to the age group 41-60 years (51.66%). In 51 patients taking Tenofovir monotherapy, 41 patients (80.40%) were having ≤2000 IU/mL. In 6 patients taking Entecavir monotherapy, 3 patients (50%) were having ≤2000 IU/mL. In 3 patients taking Dual therapy, 2 patients (66.67%) were having ≤2000 IU/mL. Among 60 patients, ADRs were reported in 41 patients (68.33%). Commonly reported ADRs were weakness, headache, dizziness, abdominal pain. These are mild and occasional. 73.40% patients reported ADRs while using Tenofovir and 83.33% patients reported ADRs while using Entecavir. From our study, it was observed that Tenofovir is having good safety and efficacy (80.40%) whereas Entecavir is having 50% efficacy. Tenofovir safety and efficacy is much more when compared to safety and efficacy of Entecavir.","PeriodicalId":14906,"journal":{"name":"Journal of Advanced Scientific Research","volume":"89 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139347182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This study demonstrates application of Impedance Spectroscopy Genetic Program (ISGP) for the investigation of a polymer electrolyte membrane fuel cell (PEMFC). It further demonstrates the procedures to optimize the operating conditions of a single cell in a test station. To do that, the effects of temperature, hydrogen/air, and dew point temperature (DPT) on the cell were examined using an Arbin test station. ISGP followed a two-iteration procedure. First, find an out-of-range peak (at high frequencies) that corresponds to the ohmic (series) resistance of the system. Second, finding the models after subtracting the ohmic resistance from the real part of the measured spectrum. This two- step procedure allows solving a Fredholm equation of the second kind with a reasonable accuracy. The resulting peaks making the distribution function of relaxation time (DFRT) were partially assigned to different physical processes in the PEMFCs. ISGP seeks for a distribution of relaxation times that has the form of a peak or a sum of several peaks, assuming the Debye kernel, where each peak is represented by a known analytic function. As a part of the analysis, the peak areas, which correspond to the contribution of the relevant process to the total impedance, were calculated obtaining tendentious behavior depending on the changing environmental parameters. ISGP of PEMFC results in three peaks. The optimized conditions were found to be the ratio of gas flow fuel to air rate 1:7, fuel cell temperature 60°C and dew point temperature 50°C.
{"title":"IMPEDANCE SPECTROSCOPY GENETIC PROGRAMMING (ISGP) ANALYSES SETTING PROPER WORKING CONDITIONS OF A POLYMER ELECTROLYTE MEMBRANE FUEL CELL","authors":"Nimai Bar, Rajkamal Pandit","doi":"10.55218/jasr.202314701","DOIUrl":"https://doi.org/10.55218/jasr.202314701","url":null,"abstract":"This study demonstrates application of Impedance Spectroscopy Genetic Program (ISGP) for the investigation of a polymer electrolyte membrane fuel cell (PEMFC). It further demonstrates the procedures to optimize the operating conditions of a single cell in a test station. To do that, the effects of temperature, hydrogen/air, and dew point temperature (DPT) on the cell were examined using an Arbin test station. ISGP followed a two-iteration procedure. First, find an out-of-range peak (at high frequencies) that corresponds to the ohmic (series) resistance of the system. Second, finding the models after subtracting the ohmic resistance from the real part of the measured spectrum. This two- step procedure allows solving a Fredholm equation of the second kind with a reasonable accuracy. The resulting peaks making the distribution function of relaxation time (DFRT) were partially assigned to different physical processes in the PEMFCs. ISGP seeks for a distribution of relaxation times that has the form of a peak or a sum of several peaks, assuming the Debye kernel, where each peak is represented by a known analytic function. As a part of the analysis, the peak areas, which correspond to the contribution of the relevant process to the total impedance, were calculated obtaining tendentious behavior depending on the changing environmental parameters. ISGP of PEMFC results in three peaks. The optimized conditions were found to be the ratio of gas flow fuel to air rate 1:7, fuel cell temperature 60°C and dew point temperature 50°C.","PeriodicalId":14906,"journal":{"name":"Journal of Advanced Scientific Research","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139347648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Plants show various medicinal properties due to presence of phytoconstituents. Gas chromatography-mass spectroscopy is a technique which is used to identify compounds in a plant extract on the basis of retention time and their mass. In the current investigation, petroleum ether extracts of seed of Psoralea corylifolia (family Leguminosae) was subjected for GC- MS analysis. Total 51 compounds were identified out of which many are significant as having antioxidant potential such as ficusin, vitamin E, stigmasterol, gamma sitosterol etc. The extract was also subjected for their free radical scavenging potential by using DPPH assay. Results revealed the presence of good antioxidant activity of the petroleum extract.
{"title":"GC-MS ANALYSIS AND ANTIOXIDANT POTENTIAL OF PETROLEUM EXTRACT OF SEEDS OF PSORALEA CORYLOFOLIA","authors":"Lalita Kumari, Mahesh C. Sharma","doi":"10.55218/jasr.202314706","DOIUrl":"https://doi.org/10.55218/jasr.202314706","url":null,"abstract":"Plants show various medicinal properties due to presence of phytoconstituents. Gas chromatography-mass spectroscopy is a technique which is used to identify compounds in a plant extract on the basis of retention time and their mass. In the current investigation, petroleum ether extracts of seed of Psoralea corylifolia (family Leguminosae) was subjected for GC- MS analysis. Total 51 compounds were identified out of which many are significant as having antioxidant potential such as ficusin, vitamin E, stigmasterol, gamma sitosterol etc. The extract was also subjected for their free radical scavenging potential by using DPPH assay. Results revealed the presence of good antioxidant activity of the petroleum extract.","PeriodicalId":14906,"journal":{"name":"Journal of Advanced Scientific Research","volume":"162 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139347535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The liver transplant is a surgical procedure in which the diseased liver of recipient is replaced with the healthy liver of donor. Our research involved 70 patients who underwent liver transplant and it was single centered. This study’s objective was to evaluate the medications used in liver transplantation. In our study we found that most common cause for liver transplantation is cryptogenic and second most cause is alcoholic related. Immunosuppressants and prophylaxis antimicrobials were primarily prescribed. In immunosuppressants, triple drug regimen was given for 74.28% and Quadruple regimen was prescribed for 18.5%. TDM immunosuppressants were performed during hospital stay. Meropenem is the major antibiotic used as prophylactic therapy, Valganciclovir is regularly prescribed antiviral whereas Fluconazole is usually prescribed antifungal. Immunosuppressants: 74.28% patients were prescribed with tacrolimus + mycophenolate mofetil + prednisolone (Triple therapy); Tacrolimus + Mycophenolate mofetil + prednisolone + Everolimus/Cyclosporine (18.5%). Antibiotics: 78.57% of patients were prescribed with Meropenem. Antiviral: 88.57% of patients were prescribed with Valganciclovir. Antifungal: 94.28% of patients were prescribed with Fluconazole. The length of hospital stay for many patients was 16-20 days.
{"title":"A PROSPECTIVE OBSERVATIONAL STUDY ON PRESCRIBING PATTERN IN LIVER TRANSPLANT RECIPIENTS","authors":"Rama Krishna Mungi, Mekala Samhitha, Mallethula Shirisha, Md Abdul Nafey, Chandan Kumar K.N.","doi":"10.55218/jasr.202314705","DOIUrl":"https://doi.org/10.55218/jasr.202314705","url":null,"abstract":"The liver transplant is a surgical procedure in which the diseased liver of recipient is replaced with the healthy liver of donor. Our research involved 70 patients who underwent liver transplant and it was single centered. This study’s objective was to evaluate the medications used in liver transplantation. In our study we found that most common cause for liver transplantation is cryptogenic and second most cause is alcoholic related. Immunosuppressants and prophylaxis antimicrobials were primarily prescribed. In immunosuppressants, triple drug regimen was given for 74.28% and Quadruple regimen was prescribed for 18.5%. TDM immunosuppressants were performed during hospital stay. Meropenem is the major antibiotic used as prophylactic therapy, Valganciclovir is regularly prescribed antiviral whereas Fluconazole is usually prescribed antifungal. Immunosuppressants: 74.28% patients were prescribed with tacrolimus + mycophenolate mofetil + prednisolone (Triple therapy); Tacrolimus + Mycophenolate mofetil + prednisolone + Everolimus/Cyclosporine (18.5%). Antibiotics: 78.57% of patients were prescribed with Meropenem. Antiviral: 88.57% of patients were prescribed with Valganciclovir. Antifungal: 94.28% of patients were prescribed with Fluconazole. The length of hospital stay for many patients was 16-20 days.","PeriodicalId":14906,"journal":{"name":"Journal of Advanced Scientific Research","volume":"63 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139347823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Synthetic dyes have a repugnant effect on the aquatic ecosystem and their venomous components have to be removed from the effluent before their exemption. The decolourization of synthetic dyes by fungi is emerging as an effective and clean technology. Fungal-abetted processes are amongst the finest approaches for transformation, degradation and decolourization of recalcitrant dyes. This study was carried out to find out the qualities of textile effluents with the estimation of physicochemical parameters of textile effluents, isolation and identification of fungi. The physicochemical parameters were demarcatedas per the standards prescribed by CPCB.15 fungi isolated from textile effluent and effluent- contaminated soil samples were evaluated to decolourize textile dyes - Reactive Red ME-4B and Brill blue-R. 9 different fungal species were further identified as Aspergillus spp, Penicillium spp, Mucor, Curvularia spp, Helmintho sporium spp, Fusarium spp, Trichoderma spp, Rhizopus, spp and Alternaria spp by 18S rRNA Sequencing. These 9 isolates with potential decolourization were assessed via primary and secondary decolourization. The study also showed that Penicillium spp, Aspergillus spp and Trichoderma spp are highly efficient in decolorizing (85.41, 98.80and83.23 %) in 6 days as used in the present investigation. The results have demonstrated the potential of the fungal isolates for the treatment of dyes contaminated textile effluent.
{"title":"SUSTAINABLE TECHNOLOGY FOR RECALCITRANT AZO DYES BY FUNGAL SPECIES ISOLATED FROM INDUSTRIAL EFFLUENT","authors":"Pragna Pandya, Aditee Pandya","doi":"10.55218/jasr.202314703","DOIUrl":"https://doi.org/10.55218/jasr.202314703","url":null,"abstract":"Synthetic dyes have a repugnant effect on the aquatic ecosystem and their venomous components have to be removed from the effluent before their exemption. The decolourization of synthetic dyes by fungi is emerging as an effective and clean technology. Fungal-abetted processes are amongst the finest approaches for transformation, degradation and decolourization of recalcitrant dyes. This study was carried out to find out the qualities of textile effluents with the estimation of physicochemical parameters of textile effluents, isolation and identification of fungi. The physicochemical parameters were demarcatedas per the standards prescribed by CPCB.15 fungi isolated from textile effluent and effluent- contaminated soil samples were evaluated to decolourize textile dyes - Reactive Red ME-4B and Brill blue-R. 9 different fungal species were further identified as Aspergillus spp, Penicillium spp, Mucor, Curvularia spp, Helmintho sporium spp, Fusarium spp, Trichoderma spp, Rhizopus, spp and Alternaria spp by 18S rRNA Sequencing. These 9 isolates with potential decolourization were assessed via primary and secondary decolourization. The study also showed that Penicillium spp, Aspergillus spp and Trichoderma spp are highly efficient in decolorizing (85.41, 98.80and83.23 %) in 6 days as used in the present investigation. The results have demonstrated the potential of the fungal isolates for the treatment of dyes contaminated textile effluent.","PeriodicalId":14906,"journal":{"name":"Journal of Advanced Scientific Research","volume":"229 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139347173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A series of novel compounds (4a-4l) have been synthesized by Claisen-Schmidt condensation, Schiff’s base and Cyclization mechanism. All the molecule structures were affirmation by IR, 1H NMR and Mass spectral data. The synthesized hybrids were screened for in vivo anti-inflammatory and invitro anticancer activities. Ant inflammatory activity was performed using carrageenan induced rat paw edema method using Diclofenac as standard drug. The anticancer activity has been assessing by using MTT assay against MCF7 and SKOV3 cell lines and Doxorubicin was used as reference standard. Among the compounds compound 4l exhibited the highest % inhibition of 98.4 when compared with the standard Diclofenac 94.2%.Compound 4f exhibited the lowest IC50 at concentration of 20.01µg against MCF7 cell lines and 32.87µg against SKOV3 cell lines. The molecular docking studies was performed using the Ligprep tool of Schrodinger suite. This study revealed that novel thiazolidne-4-one-pyrazole hybrids(4a-4j) had good interaction with the active site of EGFR receptor. Among the docked compounds, dock score of the compounds ranged from from -3.186 to -5.212. The highest score was exhibited by 4f with -5.212 with Glide binding energy of -34.697 Kcal/mol.
{"title":"DOCKING STUDIES OF INDOLE ASSIMILATED PYRAZOLINE MOLECULAR HYBRIDS: DESIGN, SYNTHESIS AS ANTIINFLAMMATORY AGENTS AND ANTICANCER AGENTS","authors":"Prasanna Lakshmi Nattava","doi":"10.55218/jasr.202314704","DOIUrl":"https://doi.org/10.55218/jasr.202314704","url":null,"abstract":"A series of novel compounds (4a-4l) have been synthesized by Claisen-Schmidt condensation, Schiff’s base and Cyclization mechanism. All the molecule structures were affirmation by IR, 1H NMR and Mass spectral data. The synthesized hybrids were screened for in vivo anti-inflammatory and invitro anticancer activities. Ant inflammatory activity was performed using carrageenan induced rat paw edema method using Diclofenac as standard drug. The anticancer activity has been assessing by using MTT assay against MCF7 and SKOV3 cell lines and Doxorubicin was used as reference standard. Among the compounds compound 4l exhibited the highest % inhibition of 98.4 when compared with the standard Diclofenac 94.2%.Compound 4f exhibited the lowest IC50 at concentration of 20.01µg against MCF7 cell lines and 32.87µg against SKOV3 cell lines. The molecular docking studies was performed using the Ligprep tool of Schrodinger suite. This study revealed that novel thiazolidne-4-one-pyrazole hybrids(4a-4j) had good interaction with the active site of EGFR receptor. Among the docked compounds, dock score of the compounds ranged from from -3.186 to -5.212. The highest score was exhibited by 4f with -5.212 with Glide binding energy of -34.697 Kcal/mol.","PeriodicalId":14906,"journal":{"name":"Journal of Advanced Scientific Research","volume":"70 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139347848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Soma Roy, Anita Sinha, Amisha Kumari, P. K. Mishra
The cultivation of mushrooms is a biotechnological intervention for the conversion of various lignocellulose agro-wastes into proteins. Jharkhand and its neighbourhood are potential area for oyster mushroom production due to its favourable agro-climate, plenty of agro-wastes and Hypsizygus ulmarius good awareness and liking for mushroom consumption. They also provide other much needed nutrients like Essential Amino Acids (EAA), minerals and vitamins and keep us fit and healthy. Oyster mushroom cultivation in India is very popular among the farmers due to its simple growing technique and the availability of its good number of species adapted to wide range of temperature - from tropical to temperate. Pleurotus florida exhibits adaptability to perform well in sub-tropical areas and hence it is more popular in Chotanagpur Plateau in general and Ranchi District in particular. In the current study, therefore, P. florida was selected as a test species. Experiments on the species of Oyster mushroom were designed with the sole objective to reduce the input-cost of their cultivation by promoting the use of cheaper recycled agro-wastes like vermi-compost for spawn media preparation. The study concluded that supplemented spawn medium like Wheat (50%) + Vermi Compost (50%) and Wheat (75%) + Vermi Compost (25%) gave better result as well as its performance is at par with 100% wheat for the spawn production of P. florida and. So this can be recommended to spawn production laboratories for the use of this methodology for reducing the cost of spawn production. Vermi-compost, which is a waste-recycled material, has been identified as a potential substitute for cereal grains. Their replacement (partial or total) with Vermi-compost has opened the doors to make mushroom farming a complete recycling process, and also to achieve organic farming of mushrooms a reality sooner than later. Therefore, more such studies on other edible domesticated mushroom species need to be made in future.
{"title":"EFFECT OF ORGANIC SUPPLEMENT ON OYSTER MUSHROOM SPAWN PRODUCTION","authors":"Soma Roy, Anita Sinha, Amisha Kumari, P. K. Mishra","doi":"10.55218/jasr.202314702","DOIUrl":"https://doi.org/10.55218/jasr.202314702","url":null,"abstract":"The cultivation of mushrooms is a biotechnological intervention for the conversion of various lignocellulose agro-wastes into proteins. Jharkhand and its neighbourhood are potential area for oyster mushroom production due to its favourable agro-climate, plenty of agro-wastes and Hypsizygus ulmarius good awareness and liking for mushroom consumption. They also provide other much needed nutrients like Essential Amino Acids (EAA), minerals and vitamins and keep us fit and healthy. Oyster mushroom cultivation in India is very popular among the farmers due to its simple growing technique and the availability of its good number of species adapted to wide range of temperature - from tropical to temperate. Pleurotus florida exhibits adaptability to perform well in sub-tropical areas and hence it is more popular in Chotanagpur Plateau in general and Ranchi District in particular. In the current study, therefore, P. florida was selected as a test species. Experiments on the species of Oyster mushroom were designed with the sole objective to reduce the input-cost of their cultivation by promoting the use of cheaper recycled agro-wastes like vermi-compost for spawn media preparation. The study concluded that supplemented spawn medium like Wheat (50%) + Vermi Compost (50%) and Wheat (75%) + Vermi Compost (25%) gave better result as well as its performance is at par with 100% wheat for the spawn production of P. florida and. So this can be recommended to spawn production laboratories for the use of this methodology for reducing the cost of spawn production. Vermi-compost, which is a waste-recycled material, has been identified as a potential substitute for cereal grains. Their replacement (partial or total) with Vermi-compost has opened the doors to make mushroom farming a complete recycling process, and also to achieve organic farming of mushrooms a reality sooner than later. Therefore, more such studies on other edible domesticated mushroom species need to be made in future.","PeriodicalId":14906,"journal":{"name":"Journal of Advanced Scientific Research","volume":"142 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139347589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Antimicrobials are used to treat infectious diseases. However, antimicrobial agents are frequently prescribed in excess, which leads to antimicrobial resistance. As a result, the prescribing pattern of antimicrobial agents must be evaluated. The study included 100 patients. The study lasted 6 months in a tertiary health care hospital. This is a Prospective observational study. Among 100 patients, 51 were male and 49 were female. Most of patients were between the age group of 51- 60 and 61-70 (20%) in each group. The most frequently seen infectious diseases were LRTI (39%), UTI (25%), GE (13%), Dengue (6%), Sepsis (6%). The length of hospital stay in LRTI patients for less than 4 days was 41.04% and more than 4 days was 58.96%. The length of hospital stay in UTI patients for less than 4 days was 44% and more than 4 days was 56%. The most common antibiotics used were Cefoperazone-Sulbactam (25.49%) followed by Ceftriaxone (21.38%) and Oseltamivir (10.98%). In Lower Respiratory Tract Infection (LRTI) the most commonly used antimicrobial agents are Ceftriaxone (25.92%) and Oseltamivir (20.98%). In Urinary Tract Infection (UTI) the most commonly used antimicrobial agent is Cefoperazone-Sulbactam (48.29%). Ceftriaxone (22.72%) and Cefpodoxime (9.09%) are used for the treatment of Gastroenteritis (GE).
{"title":"A PROSPECTIVE OBSERVATIONAL STUDY ON PRESCRIBING PATTERN OF ANTIMICROBIAL AGENTS IN PATIENTS WITH INFECTIOUS DISEASES IN TERTIARY CARE HOSPITAL","authors":"Gunnala Pavan Sai Goud, Nihar Ranjan Das, Akula Sindhuja, Dodde Anusha, Ganta Praveen Kumar Yadav, Haricharan","doi":"10.55218/jasr.202314709","DOIUrl":"https://doi.org/10.55218/jasr.202314709","url":null,"abstract":"Antimicrobials are used to treat infectious diseases. However, antimicrobial agents are frequently prescribed in excess, which leads to antimicrobial resistance. As a result, the prescribing pattern of antimicrobial agents must be evaluated. The study included 100 patients. The study lasted 6 months in a tertiary health care hospital. This is a Prospective observational study. Among 100 patients, 51 were male and 49 were female. Most of patients were between the age group of 51- 60 and 61-70 (20%) in each group. The most frequently seen infectious diseases were LRTI (39%), UTI (25%), GE (13%), Dengue (6%), Sepsis (6%). The length of hospital stay in LRTI patients for less than 4 days was 41.04% and more than 4 days was 58.96%. The length of hospital stay in UTI patients for less than 4 days was 44% and more than 4 days was 56%. The most common antibiotics used were Cefoperazone-Sulbactam (25.49%) followed by Ceftriaxone (21.38%) and Oseltamivir (10.98%). In Lower Respiratory Tract Infection (LRTI) the most commonly used antimicrobial agents are Ceftriaxone (25.92%) and Oseltamivir (20.98%). In Urinary Tract Infection (UTI) the most commonly used antimicrobial agent is Cefoperazone-Sulbactam (48.29%). Ceftriaxone (22.72%) and Cefpodoxime (9.09%) are used for the treatment of Gastroenteritis (GE).","PeriodicalId":14906,"journal":{"name":"Journal of Advanced Scientific Research","volume":"180 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139347769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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