Pub Date : 2024-04-27DOI: 10.1080/10286020.2024.2345825
Many organic reactions rely on CO2 sources to generate important structural units and valuable chemicals. In this study, we compared the effects of cannabidiol (CBD) and cannabidiolic acid (CBDA) on the supercritical CO2 (scCO2)-induced de/carboxylation reaction. The results showed that CBD was directly carboxylated in the ortho-position to form CBDA with up to 62% conversion. Meanwhile, CBDA decarboxylation occurred on hemp plant material via varying composition. Mechanistic studies revealed that CBD carboxylation was influenced not only by the physical properties of scCO2, but also by the vegetable matrix.
{"title":"Direct de/carboxylation of cannabidiolic acid (CBDA) and cannabidiol (CBD) from hemp plant material under supercritical CO2","authors":"","doi":"10.1080/10286020.2024.2345825","DOIUrl":"10.1080/10286020.2024.2345825","url":null,"abstract":"<div><p>Many organic reactions rely on CO<sub>2</sub> sources to generate important structural units and valuable chemicals. In this study, we compared the effects of cannabidiol (CBD) and cannabidiolic acid (CBDA) on the supercritical CO<sub>2</sub> (scCO<sub>2</sub>)-induced de/carboxylation reaction. The results showed that CBD was directly carboxylated in the <em>ortho</em>-position to form CBDA with up to 62% conversion. Meanwhile, CBDA decarboxylation occurred on hemp plant material <em>via</em> varying composition. Mechanistic studies revealed that CBD carboxylation was influenced not only by the physical properties of scCO<sub>2</sub>, but also by the vegetable matrix.</p></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140874616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-20DOI: 10.1080/10286020.2024.2343821
Prinsa , Supriyo Saha , Md Zahidul Haque Bulbul , Yasuhiro Ozeki , Mubarak A. Alamri , Sarkar M. A. Kawsar
KRAS mutations linked with cancer. Flavonoids were docked against KRAS G12C and G12D receptors. Abyssinone III, alpha naphthoflavone, beta naphthoflavone, abyssinone I, abyssinone II and beta naphthoflavone, genistin, daidzin showed good docking scores against KRAS G12C and G12D receptors, respectively. The MD simulation data revealed that Rg, RMSD, RMSF, and SASA values were within acceptable limits. Alpha and beta naphthoflavone showed good binding energies with KRAS G12C and G12D receptors. DFT and MEP analysis highlighted the nucleophilic and electrophilic zones of best-docked flavonoids. A novel avenue for the control of KRAS G12C and G12D mutations is made possible by flavonoids.
{"title":"Flavonoids as potential KRAS inhibitors: DFT, molecular docking, molecular dynamics simulation and ADMET analyses","authors":"Prinsa , Supriyo Saha , Md Zahidul Haque Bulbul , Yasuhiro Ozeki , Mubarak A. Alamri , Sarkar M. A. Kawsar","doi":"10.1080/10286020.2024.2343821","DOIUrl":"10.1080/10286020.2024.2343821","url":null,"abstract":"<div><p>KRAS mutations linked with cancer. Flavonoids were docked against KRAS G12C and G12D receptors. Abyssinone III, alpha naphthoflavone, beta naphthoflavone, abyssinone I, abyssinone II and beta naphthoflavone, genistin, daidzin showed good docking scores against KRAS G12C and G12D receptors, respectively. The MD simulation data revealed that Rg, RMSD, RMSF, and SASA values were within acceptable limits. Alpha and beta naphthoflavone showed good binding energies with KRAS G12C and G12D receptors. DFT and MEP analysis highlighted the nucleophilic and electrophilic zones of best-docked flavonoids. A novel avenue for the control of KRAS G12C and G12D mutations is made possible by flavonoids.</p></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140635470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-18DOI: 10.1080/10286020.2024.2343420
Wen-Die Wang , Chao-Yang Zeng , Yue Shang , Jun Ni , Gao-Jie Li , Li-Ping Li , Shuo-Han Xi , Shu-Zhen Chen
Triple-negative breast cancer (TNBC) is an aggressive subtype with poor prognosis of breast cancer. Thiostrepton exerts anti-tumor activities against several cancers including TNBC. Herein we discussed the new molecular mechanisms of thiostrepton in TNBC. Thiostrepton inhibited MDA-MB-231 cell viability, accompanied by a decrease of c-FLIP and p-SMAD2/3. c-FLIP overexpression reduced the sensitivity of MDA-MB-231 cells to thiostrepton, while SMAD2/3 knockdown increased the sensitivity of MDA-MB-231 cells to thiostrepton. Moreover, c-FLIP overexpression significantly increased the expression and phosphorylation of SMAD2/3 proteins and vice versa. In conclusion, our study reveals c-FLIP/SMAD2/3 signaling pathway as a novel mechanism of antitumor activity of thiostrepton.
{"title":"Thiostrepton suppresses triple-negative breast cancer through downregulating c-FLIP/SMAD2/3 signaling pathway","authors":"Wen-Die Wang , Chao-Yang Zeng , Yue Shang , Jun Ni , Gao-Jie Li , Li-Ping Li , Shuo-Han Xi , Shu-Zhen Chen","doi":"10.1080/10286020.2024.2343420","DOIUrl":"10.1080/10286020.2024.2343420","url":null,"abstract":"<div><p>Triple-negative breast cancer (TNBC) is an aggressive subtype with poor prognosis of breast cancer. Thiostrepton exerts anti-tumor activities against several cancers including TNBC. Herein we discussed the new molecular mechanisms of thiostrepton in TNBC. Thiostrepton inhibited MDA-MB-231 cell viability, accompanied by a decrease of c-FLIP and p-SMAD2/3. c-FLIP overexpression reduced the sensitivity of MDA-MB-231 cells to thiostrepton, while SMAD2/3 knockdown increased the sensitivity of MDA-MB-231 cells to thiostrepton. Moreover, c-FLIP overexpression significantly increased the expression and phosphorylation of SMAD2/3 proteins and vice versa. In conclusion, our study reveals c-FLIP/SMAD2/3 signaling pathway as a novel mechanism of antitumor activity of thiostrepton.</p></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140612943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-16DOI: 10.1080/10286020.2024.2335254
Min Wang , Gui-Yang Xia , Yong-Xin Liang , Huan Xia , Peng-Cheng Lin , Sheng Lin
A new 14-membered resorcylic acid lactone (RAL14), chaetolactone A (1), along with three known ones (2−4), was obtained from the fermentation of the soil-derived fungus Chaetosphaeronema sp. SSJZ001. Their structures were established based on extensive spectroscopic data analyses (UV, IR, HRESIMS, 1D, and 2D NMR),13C NMR chemical shifts calculations coupled with the DP4+ probability method, theoretical calculations of ECD spectra, as well as X-ray diffraction analysis. All compounds were evaluated for their cytotoxic effects against A549, HO-8910, and MCF-7 cell lines.
{"title":"A new resorcylic acid lactone from the endophytic fungus Chaetosphaeronema sp.","authors":"Min Wang , Gui-Yang Xia , Yong-Xin Liang , Huan Xia , Peng-Cheng Lin , Sheng Lin","doi":"10.1080/10286020.2024.2335254","DOIUrl":"10.1080/10286020.2024.2335254","url":null,"abstract":"<div><p>A new 14-membered resorcylic acid lactone (RAL<sub>14</sub>), chaetolactone A (<strong>1</strong>), along with three known ones (<strong>2</strong>−<strong>4</strong>), was obtained from the fermentation of the soil-derived fungus <em>Chaetosphaeronema sp.</em> SSJZ001. Their structures were established based on extensive spectroscopic data analyses (UV, IR, HRESIMS, 1D, and 2D NMR),<sup>13</sup>C NMR chemical shifts calculations coupled with the DP4<sup>+</sup> probability method, theoretical calculations of ECD spectra, as well as X-ray diffraction analysis. All compounds were evaluated for their cytotoxic effects against A549, HO-8910, and MCF-7 cell lines.</p></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140613129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-16DOI: 10.1080/10286020.2024.2340072
Li-jun Luo , Xiao Liu , Yan Li , Yang Li , Li Sheng
Bicyclol is a hepatoprotective agent widely used for treating chronic hepatitis and drug-induced liver injuries in clinics. The purpose of the study was to elucidate the contribution of CYP450 enzymes to the metabolism of bicyclol using the relative activity factor approach. After incubation with human liver microsomes and recombinant human liver CYP450 enzymes, the calculated contribution of CYP3A4 and 2C19 to the metabolism of bicyclol was 85.6–90.3% and 9.2–9.7%, respectively. The metabolism was interrupted in the presence of CYP3A4 and 2C19 selective inhibitors. These findings help to predict or avoid metabolic drug–drug interactions or toxicity in clinical applications of bicyclol.
{"title":"Characterization of the metabolic contributions of cytochrome P450 isoforms to bicyclol using the relative activity factor method","authors":"Li-jun Luo , Xiao Liu , Yan Li , Yang Li , Li Sheng","doi":"10.1080/10286020.2024.2340072","DOIUrl":"10.1080/10286020.2024.2340072","url":null,"abstract":"<div><p>Bicyclol is a hepatoprotective agent widely used for treating chronic hepatitis and drug-induced liver injuries in clinics. The purpose of the study was to elucidate the contribution of CYP450 enzymes to the metabolism of bicyclol using the relative activity factor approach. After incubation with human liver microsomes and recombinant human liver CYP450 enzymes, the calculated contribution of CYP3A4 and 2C19 to the metabolism of bicyclol was 85.6–90.3% and 9.2–9.7%, respectively. The metabolism was interrupted in the presence of CYP3A4 and 2C19 selective inhibitors. These findings help to predict or avoid metabolic drug–drug interactions or toxicity in clinical applications of bicyclol.</p></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140613089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-15DOI: 10.1080/10286020.2024.2341927
Shuo Pang , Na Chen , Zhuo Li , Zhuo-Hui Luo , Wei Dong , Shan Gao , Ning Liu , Shuo Pan , Lian-Feng Zhang , Jun Chen , Ya-Jun Yang
Alzheimer’s disease is a neurodegenerative disorder characterized by the presence of neurodegenerative lesions and cognitive impairment. In this study, a series of novel palmatine derivatives were designed and synthesized through the introduction of a heteroatom using carbodiimide-mediated condensation. The synthesized compounds were then screened for toxicity and potency, leading to the identification of compound 2q, which exhibited low toxicity and high potency. Our findings demonstrated that compound 2q displayed significant neuroprotective activity in vitro, emerging as a promising candidate for Alzheimer’s disease treatment.
{"title":"Discovery of palmatine derivatives as potent neuroprotective agents","authors":"Shuo Pang , Na Chen , Zhuo Li , Zhuo-Hui Luo , Wei Dong , Shan Gao , Ning Liu , Shuo Pan , Lian-Feng Zhang , Jun Chen , Ya-Jun Yang","doi":"10.1080/10286020.2024.2341927","DOIUrl":"10.1080/10286020.2024.2341927","url":null,"abstract":"<div><p>Alzheimer’s disease is a neurodegenerative disorder characterized by the presence of neurodegenerative lesions and cognitive impairment. In this study, a series of novel palmatine derivatives were designed and synthesized through the introduction of a heteroatom using carbodiimide-mediated condensation. The synthesized compounds were then screened for toxicity and potency, leading to the identification of compound <strong>2q</strong>, which exhibited low toxicity and high potency. Our findings demonstrated that compound <strong>2q</strong> displayed significant neuroprotective activity <em>in vitro</em>, emerging as a promising candidate for Alzheimer’s disease treatment.</p></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140571055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-12DOI: 10.1080/10286020.2024.2340691
Jia-Hui Du , Xuan Zhao , Fei Zhang , Yan Wang , Kun Du , Si-Yi Ding , Wei-Sheng Feng , Zhen-Zhu Zhao
Phytochemical investigation on the fruiting bodies of the medicinal fungus Ganoderma lingzhi led to the isolation of a new norsteroid, namely ganonorsterone A (1), together with one known steroid, cyathisterol (2). The structure and absolute configuration of compound 1 were assigned by extensive analysis of MS, NMR data, and quantum-chemical calculations including electronic circular dichroism (ECD) and calculated 13C NMR-DP4+ analysis. Bioassay results showed that compound 1 displayed moderate inhibition on NO production in RAW 264.7 macrophages.
{"title":"Ganonorsterone A, a norsteroid from the medicinal fungus Ganoderma lingzhi","authors":"Jia-Hui Du , Xuan Zhao , Fei Zhang , Yan Wang , Kun Du , Si-Yi Ding , Wei-Sheng Feng , Zhen-Zhu Zhao","doi":"10.1080/10286020.2024.2340691","DOIUrl":"10.1080/10286020.2024.2340691","url":null,"abstract":"<div><p>Phytochemical investigation on the fruiting bodies of the medicinal fungus <em>Ganoderma lingzhi</em> led to the isolation of a new norsteroid, namely ganonorsterone A (<strong>1</strong>), together with one known steroid, cyathisterol (<strong>2</strong>). The structure and absolute configuration of compound <strong>1</strong> were assigned by extensive analysis of MS, NMR data, and quantum-chemical calculations including electronic circular dichroism (ECD) and calculated <sup>13</sup>C NMR-DP4+ analysis. Bioassay results showed that compound <strong>1</strong> displayed moderate inhibition on NO production in RAW 264.7 macrophages.</p></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140570658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-10DOI: 10.1080/10286020.2024.2337807
Ya-Nan Wang , Hua Jin , Hui-Rong Fan , Bao-Lian Wang
A sensitive UPLC-HRMS method was developed and validated for simultaneous quantification of four active flavonoids from Chimonanthus nitens Leaf Granules (CNLG) in biological matrix. The method was utilized in pharmacokinetic study of the four flavonoids in rats as well as other evaluation assays in vitro. It was revealed that rutin, nicotiflorin, and astragalin had poor oral bioavailability in rats possibly due to low intestinal permeability and metabolism in intestinal flora. Kaempferol underwent rapid glucuronidation and sulphation in rat plasma with medium permeability coefficient. The results provided valuable data for future research and development of CNLG flavonoids.
{"title":"Simultaneous assessment of absorption and pharmacokinetic characteristics of four active flavonoids from Chimonanthus nitens Leaf Granules using LC-MS determination: in vivo and in vitro","authors":"Ya-Nan Wang , Hua Jin , Hui-Rong Fan , Bao-Lian Wang","doi":"10.1080/10286020.2024.2337807","DOIUrl":"10.1080/10286020.2024.2337807","url":null,"abstract":"<div><p>A sensitive UPLC-HRMS method was developed and validated for simultaneous quantification of four active flavonoids from Chimonanthus nitens Leaf Granules (CNLG) in biological matrix. The method was utilized in pharmacokinetic study of the four flavonoids in rats as well as other evaluation assays <em>in vitro</em>. It was revealed that rutin, nicotiflorin, and astragalin had poor oral bioavailability in rats possibly due to low intestinal permeability and metabolism in intestinal flora. Kaempferol underwent rapid glucuronidation and sulphation in rat plasma with medium permeability coefficient. The results provided valuable data for future research and development of CNLG flavonoids.</p></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140570669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-10DOI: 10.1080/10286020.2024.2340075
Yan-Wu Chen , Shi-Li Wu , Fa-Wu Dong , Rui Yang , Hong-Ping He
Four new tirucallane-type triterpenoids, polystanins H–K (1–4), were obtained from the stems and leaves of Aphanamixis polystachya. Their structures were elucidated by analysis of the spectroscopic data and comparison with literature data. Compounds 1 and 2 showed week inhibitory effects against NO production in LPS-stimulated RAW264.7 cells. All the isolates were investigated for their antifungal activities against drug-resistant Candida albicans.
{"title":"Four new tirucallane-type triterpenoids from Aphanamixis polystachya","authors":"Yan-Wu Chen , Shi-Li Wu , Fa-Wu Dong , Rui Yang , Hong-Ping He","doi":"10.1080/10286020.2024.2340075","DOIUrl":"10.1080/10286020.2024.2340075","url":null,"abstract":"<div><p>Four new tirucallane-type triterpenoids, polystanins H–K (<strong>1</strong>–<strong>4</strong>), were obtained from the stems and leaves of <em>Aphanamixis polystachya</em>. Their structures were elucidated by analysis of the spectroscopic data and comparison with literature data. Compounds <strong>1</strong> and <strong>2</strong> showed week inhibitory effects against NO production in LPS-stimulated RAW264.7 cells. All the isolates were investigated for their antifungal activities against drug-resistant <em>Candida albicans</em>.</p></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140603440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-10DOI: 10.1080/10286020.2024.2340074
Qing-Jiang Xu , Jia-Chen Liu , Cheng-Jin Huang , Xin Wang , Xiao-Ya Shang
Two new triterpene fatty acid esters, 3β-palmityloxy-12,27-cyclofriedoolean-14-en-11α-ol (1) and 3β-palmityloxy-19α-hydroxyursane (2), together with 3β-hydroxy-11-oxo-olean-12-enyl palmitate (3) were isolated from the potent anti-inflammatory active fraction of the petroleum ether-soluble part of Cirsium setosum ethanol extract. Compound 1 was found to be a rare 12,27-cyclopropane triterpenoid. Their structures were determined through spectral data analysis combined with literature reports. Furthermore, in vitro experiment, compounds 1-3 exhibited significant inhibitory effects on nitric oxide production in lipopolysaccharide-activated mouse RAW264.7 macrophages.
{"title":"Triterpene esters of cirsium setosum and their anti-inflammatory activity","authors":"Qing-Jiang Xu , Jia-Chen Liu , Cheng-Jin Huang , Xin Wang , Xiao-Ya Shang","doi":"10.1080/10286020.2024.2340074","DOIUrl":"10.1080/10286020.2024.2340074","url":null,"abstract":"<div><p>Two new triterpene fatty acid esters, 3<em>β</em>-palmityloxy-12,27-cyclofriedoolean-14-en-11<em>α</em>-ol (<strong>1</strong>) and 3<em>β</em>-palmityloxy-19<em>α</em>-hydroxyursane (<strong>2</strong>), together with 3<em>β</em>-hydroxy-11-oxo-olean-12-enyl palmitate (<strong>3</strong>) were isolated from the potent anti-inflammatory active fraction of the petroleum ether-soluble part of <em>Cirsium setosum</em> ethanol extract. Compound <strong>1</strong> was found to be a rare 12,27-cyclopropane triterpenoid. Their structures were determined through spectral data analysis combined with literature reports. Furthermore, <em>in vitro</em> experiment, compounds <strong>1</strong>-<strong>3</strong> exhibited significant inhibitory effects on nitric oxide production in lipopolysaccharide-activated mouse RAW264.7 macrophages.</p></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140570675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}