Pub Date : 2025-11-02DOI: 10.1080/10286020.2025.2525322
Fang-Ting Wei , Le-Ling Song , Jin-Qiu Ren , Xiao-Qiang Lei , Qing-Lan Guo , Jian-Gong Shi
Six undescribed minor lactones (uncarterolides A–F, 1–6) were isolated from a water decoction of the hook-bearing stems of Uncaria rhynchophylla (gou-teng). Their structures were determined by spectroscopic data analysis, along with electronic circular dichroism (ECD) and NMR calculations. Compounds 3–6 are abnormal homo-monoterpene enolic ether lactones sharing structural features with monoterpene alkaloids from gou-teng, as well as compounds 3 and 6 attenuated APAP-induced HepG2 cell damage by increasing the cell viability from 59.39% to 75.87% and 74.43%, respectively.
从钩藤（Uncaria rhynchophyla, gouteng）钩茎水煎液中分离得到6个未描述的微量内酯（uncarterolides a - f, 1-6）。通过光谱数据分析、电子圆二色性（ECD）和核磁共振计算确定了它们的结构。化合物3 ~ 6为异常同型单萜烯醛内酯，结构特征与猪藤单萜生物碱相同，化合物3、6可将apap诱导的HepG2细胞损伤从59.39%提高到75.87%和74.43%。
{"title":"Minor lactones from a water decoction of the hook-bearing stem of Uncaria rhynchophylla","authors":"Fang-Ting Wei , Le-Ling Song , Jin-Qiu Ren , Xiao-Qiang Lei , Qing-Lan Guo , Jian-Gong Shi","doi":"10.1080/10286020.2025.2525322","DOIUrl":"10.1080/10286020.2025.2525322","url":null,"abstract":"<div><div>Six undescribed minor lactones (uncarterolides A–F, <strong>1</strong>–<strong>6</strong>) were isolated from a water decoction of the hook-bearing stems of <em>Uncaria rhynchophylla</em> (gou-teng). Their structures were determined by spectroscopic data analysis, along with electronic circular dichroism (ECD) and NMR calculations. Compounds <strong>3–6</strong> are abnormal homo-monoterpene enolic ether lactones sharing structural features with monoterpene alkaloids from gou-teng, as well as compounds <strong>3</strong> and <strong>6</strong> attenuated APAP-induced HepG2 cell damage by increasing the cell viability from 59.39% to 75.87% and 74.43%, respectively.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 11","pages":"Pages 1630-1640"},"PeriodicalIF":1.3,"publicationDate":"2025-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-02DOI: 10.1080/10286020.2025.2539163
Li-Li Ye , Mei-Zhen Ye , Qiao Long , Ying-Ying Fei , Ting-Ting Li , Lin Chen , Shuai Huang , Xian-Li Zhou
Four new diterpenoid alkaloids, namely liaotungenses A–D, along with twenty known constituents, were isolated from the roots of Aconitum liaotungense Nakai (Ranunculaceae). Liaotungensines A and B are rare franchetine-type C19-diterpenoid alkaloids characterized by their unique dual hydroxylation pattern at C-13 and C-15. Liaotungense D is identified as the third documented example of 8,15-seco diterpenoid alkaloids in this structural class. Structural characterization was achieved through integrated spectroscopic analysis employing IR, HR-ESI-MS, and comprehensive 1D/2D NMR techniques. All isolated compounds underwent evaluation for anti-inflammatory potential via nitric oxide (NO) production inhibition assays, but none demonstrated marked inhibitory activity in this pharmacological assessment.
{"title":"Diterpenoid alkaloids from Aconitum liaotungenses","authors":"Li-Li Ye , Mei-Zhen Ye , Qiao Long , Ying-Ying Fei , Ting-Ting Li , Lin Chen , Shuai Huang , Xian-Li Zhou","doi":"10.1080/10286020.2025.2539163","DOIUrl":"10.1080/10286020.2025.2539163","url":null,"abstract":"<div><div>Four new diterpenoid alkaloids, namely liaotungenses A–D, along with twenty known constituents, were isolated from the roots of <em>Aconitum liaotungense</em> Nakai (Ranunculaceae). Liaotungensines A and B are rare franchetine-type C<sub>19</sub>-diterpenoid alkaloids characterized by their unique dual hydroxylation pattern at C-13 and C-15. Liaotungense D is identified as the third documented example of 8,15-seco diterpenoid alkaloids in this structural class. Structural characterization was achieved through integrated spectroscopic analysis employing IR, HR-ESI-MS, and comprehensive 1D/2D NMR techniques. All isolated compounds underwent evaluation for anti-inflammatory potential via nitric oxide (NO) production inhibition assays, but none demonstrated marked inhibitory activity in this pharmacological assessment.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 11","pages":"Pages 1608-1618"},"PeriodicalIF":1.3,"publicationDate":"2025-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144873324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
We studied the protective effects of Radix Astragali (RA) on gastric ulcer (GU). A literature search was conducted using databases from Web of Science, PubMed, Springer, ScienceDirect, Science Direct Chinese National Knowledge Infrastructure (CNKI), and Wanfang. The inclusion criteria for this study were limited to reports on the effects of RA, AS-IV, cycloastragenol, astragalus polysaccharide (APS), and astragalosides (AST) in the treatment of gastric ulcers. Any studies involving gastric lesions that were precancerous or cancerous were eliminated. The search period was from database inception through June 2024. The results suggested RA hold promiseas potential novel therapeutics for the therapy of GU.
研究了黄芪（RA）对胃溃疡的保护作用。使用Web of Science、PubMed、b施普林格、ScienceDirect、ScienceDirect Chinese National Knowledge Infrastructure （CNKI）和万方数据库进行文献检索。本研究的纳入标准仅限于RA、AS-IV、环黄芪醇、黄芪多糖（APS）和黄芪甲苷（AST）治疗胃溃疡的疗效。任何涉及癌前或癌性胃病变的研究都被排除。搜索周期从数据库建立到2024年6月。结果表明，RA有望成为治疗GU的潜在新疗法。
{"title":"Unlocking the potential of Radix Astragali and its active ingredients in gastric ulcer therapy","authors":"Pei-Pei Zhang , Jing-Ni Tang , Bo-Yu Xiang , Liang Li , Meng-Zhou Xie , Hao-Yu Qu","doi":"10.1080/10286020.2025.2475475","DOIUrl":"10.1080/10286020.2025.2475475","url":null,"abstract":"<div><div>We studied the protective effects of Radix Astragali (RA) on gastric ulcer (GU). A literature search was conducted using databases from Web of Science, PubMed, Springer, ScienceDirect, Science Direct Chinese National Knowledge Infrastructure (CNKI), and Wanfang. The inclusion criteria for this study were limited to reports on the effects of RA, AS-IV, cycloastragenol, astragalus polysaccharide (APS), and astragalosides (AST) in the treatment of gastric ulcers. Any studies involving gastric lesions that were precancerous or cancerous were eliminated. The search period was from database inception through June 2024. The results suggested RA hold promiseas potential novel therapeutics for the therapy of GU.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 11","pages":"Pages 1658-1672"},"PeriodicalIF":1.3,"publicationDate":"2025-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-02DOI: 10.1080/10286020.2025.2473648
Qi-Fen Huang , Jia-Min Zeng , Yuan-Long Hu , Wan-Yan Li , Qing-He Yu , Peng Wang , Pei-Hua Ren , Yang Peng , Wei-Jie Guan , Ran Lin , Zhen-Qiu Li , Wei-Lu Tan , Han-Ping Zhu , Shou-Xie Huang , Da-Peng Zhang , Zi-Chen Jie , Zhi-Juan Wu , Zhi-Min Zhang
Acute lung injury (ALI) has high morbidity and mortality. Lifei Qingchang Tang (LFQCT), a traditional Chinese medicine, has antioxidant and anti-inflammatory properties but its mechanism in ALI remains unclear. In vitro, LFQCT reduced intracellular Ca2+, ROS, and NO in LPS-induced RAW 264.7 cells, suppressed pro-inflammatory mediators (TNF-α, IL-1β, and IL-6), iNOS, and COX-2, and blocked phosphorylation of IKK-α/β, p65, ERK1/2, JNK1/2, and p38. It also inhibited p65 activation and nuclear translocation. In vivo, LFQCT attenuated ALI in mice by reducing cytokines in serum, BALF, and lung tissues, improving pulmonary function and survival rates, being a potential new treatment.
{"title":"Lifei Qingchang Tang attenuates acute lung injury via the NF-κB and MAPK signaling pathways","authors":"Qi-Fen Huang , Jia-Min Zeng , Yuan-Long Hu , Wan-Yan Li , Qing-He Yu , Peng Wang , Pei-Hua Ren , Yang Peng , Wei-Jie Guan , Ran Lin , Zhen-Qiu Li , Wei-Lu Tan , Han-Ping Zhu , Shou-Xie Huang , Da-Peng Zhang , Zi-Chen Jie , Zhi-Juan Wu , Zhi-Min Zhang","doi":"10.1080/10286020.2025.2473648","DOIUrl":"10.1080/10286020.2025.2473648","url":null,"abstract":"<div><div>Acute lung injury (ALI) has high morbidity and mortality. Lifei Qingchang Tang (LFQCT), a traditional Chinese medicine, has antioxidant and anti-inflammatory properties but its mechanism in ALI remains unclear. <em>In vitro</em>, LFQCT reduced intracellular Ca<sup>2+</sup>, ROS, and NO in LPS-induced RAW 264.7 cells, suppressed pro-inflammatory mediators (TNF-α, IL-1β, and IL-6), iNOS, and COX-2, and blocked phosphorylation of IKK-α/β, p65, ERK1/2, JNK1/2, and p38. It also inhibited p65 activation and nuclear translocation. <em>In vivo</em>, LFQCT attenuated ALI in mice by reducing cytokines in serum, BALF, and lung tissues, improving pulmonary function and survival rates, being a potential new treatment.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 11","pages":"Pages 1690-1705"},"PeriodicalIF":1.3,"publicationDate":"2025-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-02DOI: 10.1080/10286020.2025.2567445
Chuan-Lu Fu , Ping Ying , Wei-Ming Huang , Ze Liu , Zi-Wei Jia , Qiang Zheng , You-Jun Wu , Ling-Yi Kong , Wen-Jun Xu
Six undescribed meroterpenoids, designated as hyperwightianols I-N (1–6), were isolated from the dried whole herb of Hypericum wightianum. The structures of these compounds were elucidated through comprehensive spectroscopic analyses, including high-resolution mass spectrometry (HRMS), 1D & 2D nuclear magnetic resonance spectroscopy (NMR), as well as electronic circular dichroism (ECD). Compounds 1–3 featured a chromone core hybridized with a monoterpene unit (geranyl or geranyl-derived groups), while 4–6 were characterized by benzoic acid or cinnamic acid cores hybridized with a lavandulyl unit. In all cases, the monoterpene fragments were linked to the core structures via C-4 ether bond.
{"title":"Hyperwightianols I-N, six new meroterpenoids from Hypericum wightianum","authors":"Chuan-Lu Fu , Ping Ying , Wei-Ming Huang , Ze Liu , Zi-Wei Jia , Qiang Zheng , You-Jun Wu , Ling-Yi Kong , Wen-Jun Xu","doi":"10.1080/10286020.2025.2567445","DOIUrl":"10.1080/10286020.2025.2567445","url":null,"abstract":"<div><div>Six undescribed meroterpenoids, designated as hyperwightianols I-N (<strong>1–6</strong>), were isolated from the dried whole herb of <em>Hypericum wightianum</em>. The structures of these compounds were elucidated through comprehensive spectroscopic analyses, including high-resolution mass spectrometry (HRMS), 1D & 2D nuclear magnetic resonance spectroscopy (NMR), as well as electronic circular dichroism (ECD). Compounds <strong>1–3</strong> featured a chromone core hybridized with a monoterpene unit (geranyl or geranyl-derived groups), while <strong>4–6</strong> were characterized by benzoic acid or cinnamic acid cores hybridized with a lavandulyl unit. In all cases, the monoterpene fragments were linked to the core structures via C-4 ether bond.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 11","pages":"Pages 1588-1598"},"PeriodicalIF":1.3,"publicationDate":"2025-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145286181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-02DOI: 10.1080/10286020.2025.2488314
Tri Mayanti , Lutfiah Dwi Ramadhanti , Wahyu Safriansyah , Darwati , Nurlelasari , Desi Harneti , Siska Elisahbet Sinaga , Eri Bachtiar , Sri Hartati , Sofa Fajriah , Unang Supratman
Kokosan is a cultivar of Lansium domesticum (Meliaceae), and compounds in this variant remain limited. A new onoceranoid glycoside, lansioside E (1), along with two known onoceranoids, were isolated from the fruit peels of Kokosan. The structure of the new compound was elucidated based on spectroscopic data, including FTIR, HRTOF-MS, 1D and 2D NMR, NMR calculations (DP4+ analysis). Compounds 1–3 were evaluated for their cytotoxic activity against MCF-7 cells. Compound 3 exhibited the highest potency, with an IC50 value of 17.11 µg/ml, followed by compounds 1 and 2, with IC50 values of 39.83 and 271.90 µg/ml, respectively.
{"title":"Lansioside E, an onoceranoid-type triterpenoid isolated from the fruit peel of Lansium domesticum Corr. cv. Kokossan and its cytotoxic activity against MCF-7 breast cancer cells","authors":"Tri Mayanti , Lutfiah Dwi Ramadhanti , Wahyu Safriansyah , Darwati , Nurlelasari , Desi Harneti , Siska Elisahbet Sinaga , Eri Bachtiar , Sri Hartati , Sofa Fajriah , Unang Supratman","doi":"10.1080/10286020.2025.2488314","DOIUrl":"10.1080/10286020.2025.2488314","url":null,"abstract":"<div><div>Kokosan is a cultivar of <em>Lansium domesticum</em> (Meliaceae), and compounds in this variant remain limited. A new onoceranoid glycoside, lansioside E (<strong>1</strong>), along with two known onoceranoids, were isolated from the fruit peels of Kokosan. The structure of the new compound was elucidated based on spectroscopic data, including FTIR, HRTOF-MS, 1D and 2D NMR, NMR calculations (DP4+ analysis). Compounds <strong>1–3</strong> were evaluated for their cytotoxic activity against MCF-7 cells. Compound <strong>3</strong> exhibited the highest potency, with an IC<sub>50</sub> value of 17.11 µg/ml, followed by compounds <strong>1</strong> and <strong>2</strong>, with IC<sub>50</sub> values of 39.83 and 271.90 µg/ml, respectively.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 11","pages":"Pages 1720-1728"},"PeriodicalIF":1.3,"publicationDate":"2025-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145464851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-29DOI: 10.1080/10286020.2025.2575989
Hao-Nan Ding, Xu-Wen Wang, Yu-Xin Qian, Ke Liu, Lei Jin
Bergapten is a natural compound with the potential to regenerate bone. However, its poor solubility and instability hinder its clinical use. We developed bergapten-loaded long-circulating liposomes (BP-LCL) to overcome these challenges. The liposomes were spherical, stable, and highly effective at delivering bergapten. We found that BP-LCL were biocompatible and enhanced the osteogenic differentiation of human dental pulp stem cells. It did this by increasing key markers like RUNX2, COL1, and OCN, and by activating the Wnt/β-catenin signaling pathway. This study suggested that BP-LCL could be a promising new approach for bone regeneration settings.
{"title":"Effects of bergapten-loaded long-circulating liposomes on osteogenic differentiation of human dental pulp stem cells.","authors":"Hao-Nan Ding, Xu-Wen Wang, Yu-Xin Qian, Ke Liu, Lei Jin","doi":"10.1080/10286020.2025.2575989","DOIUrl":"https://doi.org/10.1080/10286020.2025.2575989","url":null,"abstract":"<p><p>Bergapten is a natural compound with the potential to regenerate bone. However, its poor solubility and instability hinder its clinical use. We developed bergapten-loaded long-circulating liposomes (BP-LCL) to overcome these challenges. The liposomes were spherical, stable, and highly effective at delivering bergapten. We found that BP-LCL were biocompatible and enhanced the osteogenic differentiation of human dental pulp stem cells. It did this by increasing key markers like RUNX2, COL1, and OCN, and by activating the Wnt/β-catenin signaling pathway. This study suggested that BP-LCL could be a promising new approach for bone regeneration settings.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-18"},"PeriodicalIF":1.3,"publicationDate":"2025-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145400794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-29DOI: 10.1080/10286020.2025.2577288
Zhang Hou-Run, Cheng Qi, Dong-Bao Hu, Ji-Ai Wang, Xiu Chen, Bi Xiao-Xu, Jiang-Bo He, Ying Wang
An iridoid glycoside, rhododeoside C (1), and a pyridine derivative, rhododeodine A (2), both previously undescribed, were isolated from the flowers of Rhododendron decorum. The structures were elucidated using 1D and 2D NMR spectroscopy, along with high-resolution electrospray ionization mass spectrometry (HRESIMS). The absolute configurations of both compounds were unambiguously assigned using electronic circular dichroism (ECD) computational methods. Furthermore, all isolated compounds were assessed for their cytotoxic activities against HepG2 and HeLa cell lines.
{"title":"Isolation and structural characterization of an iridoid glycoside and a pyridine derivative, both previously undescribed, from the flowers of <i>Rhododendron decorum</i>.","authors":"Zhang Hou-Run, Cheng Qi, Dong-Bao Hu, Ji-Ai Wang, Xiu Chen, Bi Xiao-Xu, Jiang-Bo He, Ying Wang","doi":"10.1080/10286020.2025.2577288","DOIUrl":"https://doi.org/10.1080/10286020.2025.2577288","url":null,"abstract":"<p><p>An iridoid glycoside, rhododeoside C (<b>1</b>), and a pyridine derivative, rhododeodine A (<b>2</b>), both previously undescribed, were isolated from the flowers of <i>Rhododendron decorum</i>. The structures were elucidated using 1D and 2D NMR spectroscopy, along with high-resolution electrospray ionization mass spectrometry (HRESIMS). The absolute configurations of both compounds were unambiguously assigned using electronic circular dichroism (ECD) computational methods. Furthermore, all isolated compounds were assessed for their cytotoxic activities against HepG2 and HeLa cell lines.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-10"},"PeriodicalIF":1.3,"publicationDate":"2025-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145400875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-29DOI: 10.1080/10286020.2025.2576668
Si-Min Wen, Ting Lv, Lei Lei, Liang-Yu Shi
Matrine, a natural compound from traditional Chinese medicine, demonstrates anti-esophageal cancer (EC) efficacy via multi-target mechanisms. In this study, integrated network pharmacology and WGCNA identified MGLL, EPHX2, and CES2 as key targets for matrine. Clinical nomograms indicated their prognostic value, and bioinformatics analysis confirmed their downregulation in EC, correlating with tumor stage, survival, and immune infiltration. Molecular docking confirmed stable binding between matrine and these targets. In vitro experiments showed matrine upregulates their expressions, concurrently inhibiting EC cell proliferation and inducing apoptosis. In conclusion, matrine treats EC through dual actions-direct antitumor effects and immunomodulation-highlighting its therapeutic potential.
{"title":"Unraveling the mechanisms of matrine in esophageal cancer treatment: insights from network pharmacology, bioinformatics, and molecular biology experiments.","authors":"Si-Min Wen, Ting Lv, Lei Lei, Liang-Yu Shi","doi":"10.1080/10286020.2025.2576668","DOIUrl":"https://doi.org/10.1080/10286020.2025.2576668","url":null,"abstract":"<p><p>Matrine, a natural compound from traditional Chinese medicine, demonstrates anti-esophageal cancer (EC) efficacy via multi-target mechanisms. In this study, integrated network pharmacology and WGCNA identified MGLL, EPHX2, and CES2 as key targets for matrine. Clinical nomograms indicated their prognostic value, and bioinformatics analysis confirmed their downregulation in EC, correlating with tumor stage, survival, and immune infiltration. Molecular docking confirmed stable binding between matrine and these targets. In vitro experiments showed matrine upregulates their expressions, concurrently inhibiting EC cell proliferation and inducing apoptosis. In conclusion, matrine treats EC through dual actions-direct antitumor effects and immunomodulation-highlighting its therapeutic potential.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-24"},"PeriodicalIF":1.3,"publicationDate":"2025-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145400831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-10-28DOI: 10.1080/10286020.2025.2577883
Dao Duc Thien, Nguyen Hoang Sa, Le Quoc Thang, Nguyen Thanh Tam
A new cyclohexenone, 5S-(3,4-dihydroxyphenethyl)cyclohex-2-en-1-one (1), along with two new phenanthrones, (4aS,10aS)- 1,9,10,10a -tetrahydro-4a,6,7-trihydroxy-4(4aH)-phenanthrone (2) and (4aS,10aS)-4a-hydroxy-7-methoxy-1,9,10,10a-tetrahydro-4(4aH)-phenanthrone 6-O-β-D-glucopyranoside (3) were isolated from the whole plant of Elatostema tenuicaudatum. The structures were determined by spectroscopic methods including 1D, 2D NMR and HR-ESI-MS. The absolute configurations of compounds 1-3 were determined by their experimental and calculated ECD spectral data. The isolates were evaluated for inhibitory activity on nitric oxide (NO) production in lipopolysaccharide (LPS)-activated RAW 264.7 macrophage cells, and compound 2 showed the strongest activity with an IC50 value of 9.5 ± 1.2 μM.
{"title":"A new cyclohexenone and two new phenanthrones from <i>Elatostema tenuicaudatum</i>.","authors":"Dao Duc Thien, Nguyen Hoang Sa, Le Quoc Thang, Nguyen Thanh Tam","doi":"10.1080/10286020.2025.2577883","DOIUrl":"https://doi.org/10.1080/10286020.2025.2577883","url":null,"abstract":"<p><p>A new cyclohexenone, 5<i>S</i>-(3,4-dihydroxyphenethyl)cyclohex-2-en-1-one (<b>1</b>), along with two new phenanthrones, (4a<i>S</i>,10a<i>S</i>)- 1,9,10,10a -tetrahydro-4a,6,7-trihydroxy-4(4a<i>H</i>)-phenanthrone (<b>2</b>) and (4a<i>S</i>,10a<i>S</i>)-4a-hydroxy-7-methoxy-1,9,10,10a-tetrahydro-4(4a<i>H</i>)-phenanthrone 6-O-<i>β</i>-D-glucopyranoside (<b>3</b>) were isolated from the whole plant of <i>Elatostema tenuicaudatum.</i> The structures were determined by spectroscopic methods including 1D, 2D NMR and HR-ESI-MS. The absolute configurations of compounds <b>1-3</b> were determined by their experimental and calculated ECD spectral data. The isolates were evaluated for inhibitory activity on nitric oxide (NO) production in lipopolysaccharide (LPS)-activated RAW 264.7 macrophage cells, and compound <b>2</b> showed the strongest activity with an IC<sub>50</sub> value of 9.5 ± 1.2 μM.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.3,"publicationDate":"2025-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145377592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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