Pub Date : 2024-12-01DOI: 10.1080/10286020.2024.2369279
Da-Min Jung , Sangsoo Lee , Eun-Mi Kim , Chong Won Choi , Kee K. Kim
Inhibition of lipid synthesis in sebocytes is essential for acne treatments. The effects of natural product-derived substances on lipid synthesis are unknown. This study investigated the effects of water extract of Mangifera indica leaves (WEML) on lipid synthesis in human sebocytes. Sebocyte differentiation in low serum conditions increased lipid accumulation and proliferator-activated receptor γ expression. WEML treatment significantly inhibited lipid accumulation and adipogenic mRNA expression in sebocytes. Mangiferin, a bioactive compound in WEML, also reduced lipid accumulation and adipogenic mRNA expression via the AKT pathway. Thus, WEML and mangiferin effectively inhibit lipid synthesis in sebocytes, showing promise for acne treatment.
{"title":"Mangiferin, a component of Mangifera indica leaf extracts, inhibits lipid synthesis in human sebocytes","authors":"Da-Min Jung , Sangsoo Lee , Eun-Mi Kim , Chong Won Choi , Kee K. Kim","doi":"10.1080/10286020.2024.2369279","DOIUrl":"10.1080/10286020.2024.2369279","url":null,"abstract":"<div><div>Inhibition of lipid synthesis in sebocytes is essential for acne treatments. The effects of natural product-derived substances on lipid synthesis are unknown. This study investigated the effects of water extract of <em>Mangifera indica</em> leaves (WEML) on lipid synthesis in human sebocytes. Sebocyte differentiation in low serum conditions increased lipid accumulation and proliferator-activated receptor γ expression. WEML treatment significantly inhibited lipid accumulation and adipogenic mRNA expression in sebocytes. Mangiferin, a bioactive compound in WEML, also reduced lipid accumulation and adipogenic mRNA expression via the AKT pathway. Thus, WEML and mangiferin effectively inhibit lipid synthesis in sebocytes, showing promise for acne treatment.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"26 12","pages":"Pages 1489-1501"},"PeriodicalIF":1.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141476652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-01DOI: 10.1080/10286020.2024.2412762
Yan-Fei Liu , Shi-Shan Yu
The new natural products reported in 2023 in peer-reviewed articles in journals with good reputations were reviewed and analyzed. The advances made by Asian research groups in the field of natural products chemistry in 2023 were summarized. Compounds with unique structural features and/or promising bioactivities originating from Asian natural sources were discussed based on their structural classification.
{"title":"Survey of natural products reported by Asian research groups in 2023","authors":"Yan-Fei Liu , Shi-Shan Yu","doi":"10.1080/10286020.2024.2412762","DOIUrl":"10.1080/10286020.2024.2412762","url":null,"abstract":"<div><div>The new natural products reported in 2023 in peer-reviewed articles in journals with good reputations were reviewed and analyzed. The advances made by Asian research groups in the field of natural products chemistry in 2023 were summarized. Compounds with unique structural features and/or promising bioactivities originating from Asian natural sources were discussed based on their structural classification.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"26 12","pages":"Pages 1389-1404"},"PeriodicalIF":1.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142501022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-01DOI: 10.1080/10286020.2024.2370409
Han Qiu , Sheng-Nan Zhao , Jin-Ling Han , Miao Yu , Ruo-Di Wang , Jing-Ru Fang , Yan-Zhu Luo , Ling-Juan Zhu , Xin-Sheng Yao
The SwissTargetPrediction was employed to predict the potential drug targets of the active component of Si-Miao-Yong-An decoction (SMYAD). The therapeutic targets for HF were searched in the Genecard database, and Cytoscape3.9.1 software was used to construct the "drug-component-target-disease network" diagram. In addition, the String platform was used to construct Protein-Protein Interaction (PPI) network, and the DAVID database was used for GO and KEGG analysis. AutoDockTools-1.5.6 software was used for molecular docking verification. Network pharmacology studies have shown that AKT 1, ALB, and CASP 3 are the key targets of action of SMYAD against heart failure. The active compounds are quercetin and kaempferol.
{"title":"Exploring the mechanism of Si-Miao-Yong-An decoction on heart failure based on molecular docking and network pharmacology","authors":"Han Qiu , Sheng-Nan Zhao , Jin-Ling Han , Miao Yu , Ruo-Di Wang , Jing-Ru Fang , Yan-Zhu Luo , Ling-Juan Zhu , Xin-Sheng Yao","doi":"10.1080/10286020.2024.2370409","DOIUrl":"10.1080/10286020.2024.2370409","url":null,"abstract":"<div><div>The SwissTargetPrediction was employed to predict the potential drug targets of the active component of Si-Miao-Yong-An decoction (SMYAD). The therapeutic targets for HF were searched in the Genecard database, and Cytoscape3.9.1 software was used to construct the \"drug-component-target-disease network\" diagram. In addition, the String platform was used to construct Protein-Protein Interaction (PPI) network, and the DAVID database was used for GO and KEGG analysis. AutoDockTools-1.5.6 software was used for molecular docking verification. Network pharmacology studies have shown that AKT 1, ALB, and CASP 3 are the key targets of action of SMYAD against heart failure. The active compounds are quercetin and kaempferol.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"26 12","pages":"Pages 1502-1529"},"PeriodicalIF":1.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141492122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-01DOI: 10.1080/10286020.2024.2371040
Zhang Hui , Wang Lai-Fa , Wang Xue-Qin , Deng Ling , He Bin-Sheng , Jian-Ming Li
The flavonoid compound chinonin is one of the main active components of Rhizoma anemarrhena with multiple activities, including anti-inflammatory and antioxidant properties, protection of mitochondrial function and regulation of immunity. In this paper, we reviewed recent research progress on the protective effect of chinonin on brain injury in neurological diseases. “Chinonin” OR “Mangiferin” AND “Nervous system diseases” OR “Neuroprotection” was used as the terms for search in PumMed. After discarding duplicated and irrelevant articles, a total of 23 articles relevant to chinonin published between 2012 and 2023 were identified in our study.
{"title":"Mechanisms and therapeutic potential of chinonin in nervous system diseases","authors":"Zhang Hui , Wang Lai-Fa , Wang Xue-Qin , Deng Ling , He Bin-Sheng , Jian-Ming Li","doi":"10.1080/10286020.2024.2371040","DOIUrl":"10.1080/10286020.2024.2371040","url":null,"abstract":"<div><div>The flavonoid compound chinonin is one of the main active components of <em>Rhizoma anemarrhena</em> with multiple activities, including anti-inflammatory and antioxidant properties, protection of mitochondrial function and regulation of immunity. In this paper, we reviewed recent research progress on the protective effect of chinonin on brain injury in neurological diseases. “Chinonin” OR “Mangiferin” AND “Nervous system diseases” OR “Neuroprotection” was used as the terms for search in PumMed. After discarding duplicated and irrelevant articles, a total of 23 articles relevant to chinonin published between 2012 and 2023 were identified in our study.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"26 12","pages":"Pages 1405-1420"},"PeriodicalIF":1.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141554887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-01DOI: 10.1080/10286020.2024.2368831
Natthaphitcha Khunsantiphong , May Thazin Thant , Chattarika Pengdee , Thanarat Salahong , Hnin Ei Ei Khine , Pithi Chanvorachote , Chatchai Chaotham , Boonchoo Sritularak
Dendroochreatene (1), a new phenanthrene derivative with a spirolactone ring, was isolated from the whole Dendrobium ochreatum plant together with 11 known compounds (2–12). The structure of the new compound was elucidated spectroscopically and phenolic compounds were firstly reported from D. ochreatum. Moscatilin (4), major compound isolated from D. ochreatum, was found to be cytotoxic toward H460 lung-cancer cells, with an IC50 value of 147.3 ± 0.9 µM, while loddigesiinol C (7), C-α-methoxy derivative was inactive.
{"title":"A new phenanthrene with a spirolactone ring from Dendrobium ochreatum","authors":"Natthaphitcha Khunsantiphong , May Thazin Thant , Chattarika Pengdee , Thanarat Salahong , Hnin Ei Ei Khine , Pithi Chanvorachote , Chatchai Chaotham , Boonchoo Sritularak","doi":"10.1080/10286020.2024.2368831","DOIUrl":"10.1080/10286020.2024.2368831","url":null,"abstract":"<div><div>Dendroochreatene (<strong>1</strong>), a new phenanthrene derivative with a spirolactone ring, was isolated from the whole <em>Dendrobium ochreatum</em> plant together with 11 known compounds (<strong>2</strong>–<strong>12</strong>). The structure of the new compound was elucidated spectroscopically and phenolic compounds were firstly reported from <em>D. ochreatum.</em> Moscatilin (<strong>4</strong>), major compound isolated from <em>D. ochreatum,</em> was found to be cytotoxic toward H460 lung-cancer cells, with an IC<sub>50</sub> value of 147.3 ± 0.9 µM, while loddigesiinol C (<strong>7</strong>), C-<em>α</em>-methoxy derivative was inactive.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"26 12","pages":"Pages 1543-1550"},"PeriodicalIF":1.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141432046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-01DOI: 10.1080/10286020.2024.2368841
Jing-Rong Li , Ling-Yu Li , Hai-Xin Zhang , Ming-Qin Zhong , Zhong-Mei Zou
Breast cancer is the most common malignant tumor and a major cause of mortality among women worldwide. Atramacronoid A (AM-A) is a unique natural sesquiterpene lactone isolated from the rhizome of Atractylodes macrocephala Koidz (known as Baizhu in Chinese). Our study demonstrated that AM-A triggers a specific form of cell death resembling PANoptosis-like cell death. Further analysis indicated that AM-A-induced PANoptosis-like cell death is associated with the CASP-3/PARP-GSDMD-MLKL pathways, which are mediated by mitochondrial dysfunction. These results suggest the potential of AM-A as a lead compound and offer insights for the development of therapeutic agents for breast cancer from natural products.
乳腺癌是最常见的恶性肿瘤，也是全球妇女死亡的主要原因。Atramacronoid A (AM-A) 是一种独特的天然倍半萜内酯，从白术根茎中分离出来。我们的研究表明，AM-A 能引发一种特殊形式的细胞死亡，类似于 PANoptosis 样细胞死亡。进一步的分析表明，AM-A诱导的PAN凋亡样细胞死亡与线粒体功能障碍介导的CASP-3/PARP-GSDMD-MLKL通路有关。这些结果表明，AM-A 有可能成为一种先导化合物，并为从天然产品中开发乳腺癌治疗药物提供了启示。
{"title":"Atramacronoid A induces the PANoptosis-like cell death of human breast cancer cells through the CASP-3/PARP-GSDMD-MLKL pathways","authors":"Jing-Rong Li , Ling-Yu Li , Hai-Xin Zhang , Ming-Qin Zhong , Zhong-Mei Zou","doi":"10.1080/10286020.2024.2368841","DOIUrl":"10.1080/10286020.2024.2368841","url":null,"abstract":"<div><div>Breast cancer is the most common malignant tumor and a major cause of mortality among women worldwide. Atramacronoid A (AM-A) is a unique natural sesquiterpene lactone isolated from the rhizome of <em>Atractylodes macrocephala</em> Koidz (known as Baizhu in Chinese). Our study demonstrated that AM-A triggers a specific form of cell death resembling PANoptosis-like cell death. Further analysis indicated that AM-A-induced PANoptosis-like cell death is associated with the CASP-3/PARP-GSDMD-MLKL pathways, which are mediated by mitochondrial dysfunction. These results suggest the potential of AM-A as a lead compound and offer insights for the development of therapeutic agents for breast cancer from natural products.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"26 12","pages":"Pages 1475-1488"},"PeriodicalIF":1.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141492121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-01DOI: 10.1080/10286020.2024.2366450
Bao Zhang , Hai-Hua Yuan , Jia Sun , Hang Xun , Jie Wang , Feng Qiu , Jian-Jun Wang , Xi Yao , Jin Wang , Wei Fan , Feng Tang
Five new glycosides, namely methyl 3-methoxybenzoate-4,5-di-O-β-D-glucopyranoside (1), (1aS,3aS,3R)-3-(4’-O-β-D-glucopyranosyl-3’-methoxyphenyl)-5,6-dioxa-bicyclo[3.3.0]octane-1-one (2), quinolin-4(1H)-one-3-O-β-D-glucopyranoside (3), 3-methoxy-propiophenone 4-O-(6’-β-D-xylopyranosyl)-β-D-glucopyranoside (4), methyl 3-methoxybenzoate 4-O-(6’-β-D-xylopyranosyl)-β-D-glucopyranoside (5), and one known compound, bambulignan B (6) were isolated from the culms of Phyllostachys nigra var. henonis. Their structures were determined using spectroscopic analysis. All compounds were evaluated for their DPPH radical scavenging activity. Compound 6 exhibited antioxidant activity with IC50 value of 59.5 μM (positive control, L-ascorbic acid, IC50 = 12.4 μM; 2,6-ditertbutyl-4-methyl phenol, IC50 = 11.8 μM).
{"title":"Five new glycosides from the culms of Phyllostachys nigra var. henonis","authors":"Bao Zhang , Hai-Hua Yuan , Jia Sun , Hang Xun , Jie Wang , Feng Qiu , Jian-Jun Wang , Xi Yao , Jin Wang , Wei Fan , Feng Tang","doi":"10.1080/10286020.2024.2366450","DOIUrl":"10.1080/10286020.2024.2366450","url":null,"abstract":"<div><div>Five new glycosides, namely methyl 3-methoxybenzoate-4,5-di-<em>O</em>-<em>β</em>-D-glucopyranoside <strong>(1)</strong>, (1a<em>S</em>,3a<em>S</em>,3<em>R</em>)-3-(4’-<em>O</em>-<em>β</em>-D-glucopyranosyl-3’-methoxyphenyl)-5,6-dioxa-bicyclo[3.3.0]octane-1-one <strong>(2)</strong>, quinolin-4(1<em>H</em>)-one-3-<em>O</em>-<em>β</em>-D-glucopyranoside <strong>(3)</strong>, 3-methoxy-propiophenone 4-<em>O</em>-(6’-<em>β</em>-D-xylopyranosyl)-<em>β</em>-D-glucopyranoside <strong>(4)</strong>, methyl 3-methoxybenzoate 4-<em>O</em>-(6’-<em>β</em>-D-xylopyranosyl)-<em>β</em>-D-glucopyranoside <strong>(5)</strong>, and one known compound, bambulignan B <strong>(6)</strong> were isolated from the culms of <em>Phyllostachys nigra</em> var<em>. henonis</em>. Their structures were determined using spectroscopic analysis. All compounds were evaluated for their DPPH radical scavenging activity. Compound <strong>6</strong> exhibited antioxidant activity with IC<sub>50</sub> value of 59.5 μM (positive control, L-ascorbic acid, IC<sub>50</sub> = 12.4 μM; 2,6-ditertbutyl-4-methyl phenol, IC<sub>50</sub> = 11.8 μM).</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"26 12","pages":"Pages 1421-1429"},"PeriodicalIF":1.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141498138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-01DOI: 10.1080/10286020.2024.2366008
Hui Li , Wen-Shuo Zhang , Rui Liu , Wei Wang , Li-Li Jiao , Zhi Liu , Wei Wu
This study examined the impact of Semen raphani on the absorption of ginsenosides from Panax ginseng C.A. Meyer (ginseng) using a Caco-2 cell model and Ultra-High-Performance Liquid Chromatography-Electrospray Ionization-Tandem Mass Spectrometry (UPLC-ESI-MS). Six primary ginsenosides (Rg1, Re, Rb1, Rb2, Rc, Rd) were quantified. Results showed that Semen Raphani increased the efflux rate of ginsenosides, particularly at higher concentrations, suggesting it inhibits their absorption. The research elucidates the intestinal absorption process of ginsenosides and the antagonistic mechanism of Semen Raphani against ginseng.
{"title":"Impact of radish seeds (Semen Raphani) on the absorption and transportation of ginsenosides in the Caco-2 cell model: a UPLC-ESI-MS analysis","authors":"Hui Li , Wen-Shuo Zhang , Rui Liu , Wei Wang , Li-Li Jiao , Zhi Liu , Wei Wu","doi":"10.1080/10286020.2024.2366008","DOIUrl":"10.1080/10286020.2024.2366008","url":null,"abstract":"<div><div>This study examined the impact of Semen raphani on the absorption of ginsenosides from <em>Panax ginseng</em> C.A. Meyer (ginseng) using a Caco-2 cell model and Ultra-High-Performance Liquid Chromatography-Electrospray Ionization-Tandem Mass Spectrometry (UPLC-ESI-MS). Six primary ginsenosides (Rg1, Re, Rb1, Rb2, Rc, Rd) were quantified. Results showed that Semen Raphani increased the efflux rate of ginsenosides, particularly at higher concentrations, suggesting it inhibits their absorption. The research elucidates the intestinal absorption process of ginsenosides and the antagonistic mechanism of Semen Raphani against ginseng.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"26 12","pages":"Pages 1430-1444"},"PeriodicalIF":1.3,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141310755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-20DOI: 10.1080/10286020.2024.2428228
Jia-Lin Li , Ling-Ling Liu , Zi-Rong Lin , Hai-Qi Zeng , Zhe Zhou , Yu-Hua Long
A new indigotin alkaloid, named talarindigotin A (1), along with the analogue 5H, 6H-quinindolin-11-one (2) were isolated from the mangrove endophytic fungus Talaromyces amestolkiae SCNU-F0041. Their structures were assigned on the basis of NMR, HRMS, and single-crystal X-ray diffraction analysis. In the cytotoxic bioassay, compound 1 showed great cytotoxicity against HepG2, Hela, HCT116, and Huh7 human cancer cell lines with IC50 values ranging from 2.08 to 4.58 μM.
{"title":"Talarindigotin A: a cytotoxic indigotin derivative, from the mangrove endophytic fungus Talaromyces amestolkiae SCNU-F0041","authors":"Jia-Lin Li , Ling-Ling Liu , Zi-Rong Lin , Hai-Qi Zeng , Zhe Zhou , Yu-Hua Long","doi":"10.1080/10286020.2024.2428228","DOIUrl":"10.1080/10286020.2024.2428228","url":null,"abstract":"<div><div>A new indigotin alkaloid, named talarindigotin A (<strong>1</strong>), along with the analogue 5H, 6H-quinindolin-11-one (<strong>2</strong>) were isolated from the mangrove endophytic fungus <em>Talaromyces amestolkiae</em> SCNU-F0041. Their structures were assigned on the basis of NMR, HRMS, and single-crystal X-ray diffraction analysis. In the cytotoxic bioassay, compound <strong>1</strong> showed great cytotoxicity against HepG2, Hela, HCT116, and Huh7 human cancer cell lines with IC<sub>50</sub> values ranging from 2.08 to 4.58 μM.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 4","pages":"Pages 632-638"},"PeriodicalIF":1.3,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142681849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-11-20DOI: 10.1080/10286020.2024.2429145
Nibedita Pyne, Ishita Bhattacharya, Santanu Paul
Visceral leishmaniasis still remains a leading cause of parasitic deaths, with modern pentavalent antimonials showing limited efficacy and health risks. The methanolic bark extract of the Northeastern Indian plant, Garcinia cowa, demonstrated potent leishmanicidal effects against the parasite Leishmania donovani, demonstrating IC50 values of 20-36 µg/ml, with selective toxicity for parasites over healthy cells. It induced parasite death through elevated oxidative and nitrosative stress elements, reduced arginase activity, nuclear fragmentation, cell cycle arrest, and apoptosis. A GC-MS study and molecular docking identified stigmasterol as a primary component, an antileishmanial compound that inhibits Leishmania donovani parasite efficiently.
{"title":"<i>Garcinia cowa</i> bark extract induces oxidative stress mediated cellular apoptosis in <i>Leishmania donovani</i> parasite modulated by its active phytosterol constituent.","authors":"Nibedita Pyne, Ishita Bhattacharya, Santanu Paul","doi":"10.1080/10286020.2024.2429145","DOIUrl":"https://doi.org/10.1080/10286020.2024.2429145","url":null,"abstract":"<p><p>Visceral leishmaniasis still remains a leading cause of parasitic deaths, with modern pentavalent antimonials showing limited efficacy and health risks. The methanolic bark extract of the Northeastern Indian plant, <i>Garcinia cowa</i>, demonstrated potent leishmanicidal effects against the parasite <i>Leishmania donovani</i>, demonstrating IC<sub>50</sub> values of 20-36 µg/ml, with selective toxicity for parasites over healthy cells. It induced parasite death through elevated oxidative and nitrosative stress elements, reduced arginase activity, nuclear fragmentation, cell cycle arrest, and apoptosis. A GC-MS study and molecular docking identified stigmasterol as a primary component, an antileishmanial compound that inhibits <i>Leishmania donovani</i> parasite efficiently.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-23"},"PeriodicalIF":1.3,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142681842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
扫码关注我们
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号