首页 > 最新文献

Journal of Asian Natural Products Research最新文献

英文 中文
Bacterial metabolomics: current applications for human welfare and future aspects. 细菌代谢组学:人类福祉的当前应用和未来方面。
IF 1.3 3区 医学 Q3 CHEMISTRY, APPLIED Pub Date : 2024-07-30 DOI: 10.1080/10286020.2024.2385365
Qazi Mohammad Sajid Jamal, Varish Ahmad

An imbalanced microbiome is linked to several diseases, such as cancer, inflammatory bowel disease, obesity, and even neurological disorders. Bacteria and their by-products are used for various industrial and clinical purposes. The metabolites under discussion were chosen based on their biological impacts on host and gut microbiota interactions as established by metabolome research. The separation of bacterial metabolites by using statistics and machine learning analysis creates new opportunities for applications of bacteria and their metabolites in the environmental and medical sciences. Thus, the metabolite production strategies, methodologies, and importance of bacterial metabolites for human well-being are discussed in this review.

失衡的微生物群与多种疾病有关,如癌症、炎症性肠病、肥胖甚至神经系统疾病。细菌及其副产品被用于各种工业和临床用途。根据代谢组研究确定的代谢物对宿主和肠道微生物群相互作用的生物学影响,选择了正在讨论的代谢物。利用统计学和机器学习分析分离细菌代谢物,为细菌及其代谢物在环境和医学科学中的应用创造了新的机会。因此,本综述将讨论代谢物的生产策略、方法以及细菌代谢物对人类福祉的重要性。
{"title":"Bacterial metabolomics: current applications for human welfare and future aspects.","authors":"Qazi Mohammad Sajid Jamal, Varish Ahmad","doi":"10.1080/10286020.2024.2385365","DOIUrl":"https://doi.org/10.1080/10286020.2024.2385365","url":null,"abstract":"<p><p>An imbalanced microbiome is linked to several diseases, such as cancer, inflammatory bowel disease, obesity, and even neurological disorders. Bacteria and their by-products are used for various industrial and clinical purposes. The metabolites under discussion were chosen based on their biological impacts on host and gut microbiota interactions as established by metabolome research. The separation of bacterial metabolites by using statistics and machine learning analysis creates new opportunities for applications of bacteria and their metabolites in the environmental and medical sciences. Thus, the metabolite production strategies, methodologies, and importance of bacterial metabolites for human well-being are discussed in this review.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141792521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Five anti-inflammatory compounds from the resins of Liquidambar orientalis 东方枫香树树脂中的五种抗炎化合物
IF 1.7 3区 医学 Q3 CHEMISTRY, APPLIED Pub Date : 2024-07-27 DOI: 10.1080/10286020.2024.2379978
Hao Chen, Sheng-Hong Li, Yong-Xian Cheng
Five undescribed compounds, including a triterpenoid (1), three phenylpropanoids [(±)−2 and 4], and an aromatic compound (3), as well as six known analogues (5–10), were isolated from the resins of...
我们从"...... "的树脂中分离出了五种未曾描述过的化合物,包括一种三萜类化合物(1)、三种苯丙类化合物[(±)-2 和 4]、一种芳香族化合物(3)以及六种已知的类似物(5-10)。
{"title":"Five anti-inflammatory compounds from the resins of Liquidambar orientalis","authors":"Hao Chen, Sheng-Hong Li, Yong-Xian Cheng","doi":"10.1080/10286020.2024.2379978","DOIUrl":"https://doi.org/10.1080/10286020.2024.2379978","url":null,"abstract":"Five undescribed compounds, including a triterpenoid (1), three phenylpropanoids [(±)−2 and 4], and an aromatic compound (3), as well as six known analogues (5–10), were isolated from the resins of...","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141774688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis of scaberol C amino acid ester derivatives with anti-cancer activity 具有抗癌活性的葶苈醇 C 氨基酸酯衍生物的合成
IF 1.7 3区 医学 Q3 CHEMISTRY, APPLIED Pub Date : 2024-07-27 DOI: 10.1080/10286020.2024.2380737
Cheng-Long Li, Zheng Han, Dong-Ya Luo, Hui Ren, Li Ye, Guo-Dong Yao, Qing-Bo Liu
A series of amino acid ester trifluoroacetate derivatives was synthesized from scaberol C. They were screened for their inhibitory activity against Non-Small Cell Lung Cancer (NSCLC) cells. Among t...
研究人员从葶苈醇 C 中合成了一系列三氟乙酸氨基酸酯衍生物,并对这些衍生物进行了筛选,以检测它们对非小细胞肺癌细胞(NSCLC)的抑制活性。其中...
{"title":"Synthesis of scaberol C amino acid ester derivatives with anti-cancer activity","authors":"Cheng-Long Li, Zheng Han, Dong-Ya Luo, Hui Ren, Li Ye, Guo-Dong Yao, Qing-Bo Liu","doi":"10.1080/10286020.2024.2380737","DOIUrl":"https://doi.org/10.1080/10286020.2024.2380737","url":null,"abstract":"A series of amino acid ester trifluoroacetate derivatives was synthesized from scaberol C. They were screened for their inhibitory activity against Non-Small Cell Lung Cancer (NSCLC) cells. Among t...","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141785214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Polyprenylated acylphloroglucinols from Hypericum sampsonii with cytotoxicity against pancreatic carcinomas. 对胰腺癌具有细胞毒性的金丝桃中的多烯酰化酰基氯葡萄糖醇。
IF 1.3 3区 医学 Q3 CHEMISTRY, APPLIED Pub Date : 2024-07-22 DOI: 10.1080/10286020.2024.2380744
Xin-Pei Wang, Xue-Hua Li, Jian-Jun Lei, Yu-Wei Xiao, Yang Chi, Qian Sun, He Zhang

Chemical investigation on the 80% EtOH extract of the air dried aerial parts of Hypericum sampsonii resulted in the isolation of two new polycyclic polyprenylated derivatives, hypersampines A and B (1 and 2). The structures of the new compounds were elucidated by spectroscopic data (NMR, IR, and UV) and high resolution mass analysis. The two isolated polyprenylated acylphloroglucinols were tested in vitro for cytotoxic activities against 6 pancreatic cell lines. As a result, compounds 1 and 2 possessed modest cytotoxic activities against all the tested tumor cell lines with IC50 values less than 40 μM.

对风干的金丝桃(Hypericum sampsonii)气生部分的 80% EtOH 提取物进行化学研究后,分离出了两种新的多环多烯基衍生物--hypersampines A 和 B(1 和 2)。新化合物的结构通过光谱数据(核磁共振、红外光谱和紫外光谱)和高分辨率质量分析得以阐明。在体外测试了这两种分离出的多烯酰化酰基氯葡萄糖醇对 6 种胰腺细胞系的细胞毒性活性。结果表明,化合物 1 和 2 对所有测试的肿瘤细胞株都具有适度的细胞毒性活性,其 IC50 值小于 40 μM。
{"title":"Polyprenylated acylphloroglucinols from <i>Hypericum sampsonii</i> with cytotoxicity against pancreatic carcinomas.","authors":"Xin-Pei Wang, Xue-Hua Li, Jian-Jun Lei, Yu-Wei Xiao, Yang Chi, Qian Sun, He Zhang","doi":"10.1080/10286020.2024.2380744","DOIUrl":"https://doi.org/10.1080/10286020.2024.2380744","url":null,"abstract":"<p><p>Chemical investigation on the 80% EtOH extract of the air dried aerial parts of <i>Hypericum sampsonii</i> resulted in the isolation of two new polycyclic polyprenylated derivatives, hypersampines A and B (<b>1</b> and <b>2</b>). The structures of the new compounds were elucidated by spectroscopic data (NMR, IR, and UV) and high resolution mass analysis. The two isolated polyprenylated acylphloroglucinols were tested <i>in vitro</i> for cytotoxic activities against 6 pancreatic cell lines. As a result, compounds <b>1</b> and <b>2</b> possessed modest cytotoxic activities against all the tested tumor cell lines with IC<sub>50</sub> values less than 40 μM.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141734180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Online identification of chemical constituents in Mongolian medicine Zhachong-13 pills by UHPLC-Q-exactive Orbitrap MS. 超高效液相色谱-Q-反应式 Orbitrap MS 在线鉴定蒙药扎冲十三味丸中的化学成分
IF 1.3 3区 医学 Q3 CHEMISTRY, APPLIED Pub Date : 2024-07-22 DOI: 10.1080/10286020.2024.2379981
Cai-Yun Tian, Qing-Rui Yang, Ling-Xuan Fan, Yu-Mei Yang, Bo-Wen Gao, Jian-Bo Yang

Zhachong-13 pills (ZC-13), as a traditional prescription of Mongolian medicine, are often used in the clinical practice of Mongolian hospitals for the treatment of stroke and rheumatic arthritis. In this experiment, UHPLC-Q-Exactive Orbitrap MS was used to explore the chemical composition of ZC-13. The results showed that 315 compounds were identified or inferred, including 56 alkaloids, 77 2-(2-phenylethyl)chromones, 61 flavonoids, 31 tannins, 8 coumarins, 16 lignans, 21 terpenoids, 5 amino acids, 19 organic acids, and 21 other components. In addition, the pharmacological activities related to anti-cerebral ischemia of these components were summarized. This result laid a foundation for further study on the pharmacodynamic material basis of ZC-13 and provided a scientific basis for the formulation of ZC-13 quality specifications.

扎冲十三味丸(ZC-13)是蒙医药的传统处方,在蒙医医院临床上经常用于治疗中风和风湿性关节炎。本实验采用超高效液相色谱-Q-Exactive Orbitrap MS对ZC-13的化学成分进行了研究。结果表明,共鉴定或推断出 315 种化合物,其中包括 56 种生物碱、77 种 2-(2-苯基乙基)色酮、61 种黄酮类、31 种鞣质、8 种香豆素、16 种木质素、21 种萜类、5 种氨基酸、19 种有机酸和 21 种其他成分。此外,还总结了这些成分在抗脑缺血方面的药理活性。这一结果为进一步研究 ZC-13 的药效物质基础奠定了基础,也为制定 ZC-13 质量标准提供了科学依据。
{"title":"Online identification of chemical constituents in Mongolian medicine Zhachong-13 pills by UHPLC-Q-exactive Orbitrap MS.","authors":"Cai-Yun Tian, Qing-Rui Yang, Ling-Xuan Fan, Yu-Mei Yang, Bo-Wen Gao, Jian-Bo Yang","doi":"10.1080/10286020.2024.2379981","DOIUrl":"https://doi.org/10.1080/10286020.2024.2379981","url":null,"abstract":"<p><p>Zhachong-13 pills (ZC-13), as a traditional prescription of Mongolian medicine, are often used in the clinical practice of Mongolian hospitals for the treatment of stroke and rheumatic arthritis. In this experiment, UHPLC-Q-Exactive Orbitrap MS was used to explore the chemical composition of ZC-13. The results showed that 315 compounds were identified or inferred, including 56 alkaloids, 77 2-(2-phenylethyl)chromones, 61 flavonoids, 31 tannins, 8 coumarins, 16 lignans, 21 terpenoids, 5 amino acids, 19 organic acids, and 21 other components. In addition, the pharmacological activities related to anti-cerebral ischemia of these components were summarized. This result laid a foundation for further study on the pharmacodynamic material basis of ZC-13 and provided a scientific basis for the formulation of ZC-13 quality specifications.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141734179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Screening of GLP-1r agonists from natural products using affinity ultrafiltration screening coupled with UPLC-ESI-Orbitrap-MS technology: a case study of Panax ginseng. 利用 UPLC-ESI-Orbitrap-MS 技术进行亲和超滤筛选,从天然产品中筛选 GLP-1r 激动剂:三七案例研究。
IF 1.3 3区 医学 Q3 CHEMISTRY, APPLIED Pub Date : 2024-07-22 DOI: 10.1080/10286020.2024.2378821
Hong-Ping Wang, Zhao-Zhou Lin, Qiong Yin, Jing Du

In our study, a method based on affinity ultrafiltration screening coupled with UPLC-ESI-Orbitrap-MS technology was established to select Glucagon-like peptide-1 receptor (GLP-1R) agonists from natural products, and as an example, the GLP-1R agonists from Panax ginseng was selected using our established method. As a result, total five GLP-1R agonists were selected from Panax ginseng for the first time. Our results indicated that activating GLP-1R to promote insulin secretion probably was another important hypoglycemia mechanism for ginsenosides in Panax ginseng, which had great influence on the study of the anti-diabetes effect of ginsenosides.

我们的研究建立了一种基于亲和超滤筛选结合UPLC-ESI-Orbitrap-MS技术从天然产物中筛选胰高血糖素样肽-1受体(GLP-1R)激动剂的方法,并以我们建立的方法从三七中筛选出的GLP-1R激动剂为例。结果,首次从三七中筛选出了五种 GLP-1R 激动剂。我们的研究结果表明,激活GLP-1R促进胰岛素分泌可能是人参中人参皂苷的另一重要降血糖机制,这对研究人参皂苷的抗糖尿病作用具有重要影响。
{"title":"Screening of GLP-1r agonists from natural products using affinity ultrafiltration screening coupled with UPLC-ESI-Orbitrap-MS technology: a case study of <i>Panax ginseng</i>.","authors":"Hong-Ping Wang, Zhao-Zhou Lin, Qiong Yin, Jing Du","doi":"10.1080/10286020.2024.2378821","DOIUrl":"https://doi.org/10.1080/10286020.2024.2378821","url":null,"abstract":"<p><p>In our study, a method based on affinity ultrafiltration screening coupled with UPLC-ESI-Orbitrap-MS technology was established to select Glucagon-like peptide-1 receptor (GLP-1R) agonists from natural products, and as an example, the GLP-1R agonists from <i>Panax ginseng</i> was selected using our established method. As a result, total five GLP-1R agonists were selected from <i>Panax ginseng</i> for the first time. Our results indicated that activating GLP-1R to promote insulin secretion probably was another important hypoglycemia mechanism for ginsenosides in <i>Panax ginseng</i>, which had great influence on the study of the anti-diabetes effect of ginsenosides.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141734181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Harmine inhibits the proliferation and migration and promotes the apoptosis of colon cancer cells via inhibition of the FAK/AKT and ERK1/2/CREB signaling pathways. Harmine 通过抑制 FAK/AKT 和 ERK1/2/CREB 信号通路,抑制结肠癌细胞的增殖和迁移,并促进其凋亡。
IF 1.3 3区 医学 Q3 CHEMISTRY, APPLIED Pub Date : 2024-07-13 DOI: 10.1080/10286020.2024.2361767
Fu-Hong Liu, Xing-Cheng Lin, Yu-Wei Liu, Tian-Tian Zhang, Yang-Bo Zhang, Zhuo-Long Xie, Yuan Zhan, Ping Hu

Harmine is present in a variety of medicinal plants, and its effects on colon cancer cells remain unclear. Here, we found that harmine exhibited significant inhibitory effects on the proliferation of colon cancer cells by inhibiting the phosphorylation levels of the FAK/AKT and ERK1/2/CREB. Furthermore, harmine also inhibited the migration of colon cancer cells and suppressed the expression levels of MMP-2, MMP-9, and VEGF. Additionally, harmine-induced apoptosis in colon cancer cells by regulating the expression of Bcl-2 and Bax. In conclusion, our findings suggest that harmine exerts a significant inhibitory effect on the development of colon cancer cells.

胭脂虫碱存在于多种药用植物中,它对结肠癌细胞的影响尚不清楚。在这里,我们发现鹤顶红通过抑制FAK/AKT和ERK1/2/CREB的磷酸化水平,对结肠癌细胞的增殖有明显的抑制作用。此外,鹤顶红还能抑制结肠癌细胞的迁移,并抑制MMP-2、MMP-9和血管内皮生长因子的表达水平。此外,加害碱还能通过调节 Bcl-2 和 Bax 的表达诱导结肠癌细胞凋亡。总之,我们的研究结果表明,鹤顶红对结肠癌细胞的发展具有显著的抑制作用。
{"title":"Harmine inhibits the proliferation and migration and promotes the apoptosis of colon cancer cells via inhibition of the FAK/AKT and ERK<sub>1/2</sub>/CREB signaling pathways.","authors":"Fu-Hong Liu, Xing-Cheng Lin, Yu-Wei Liu, Tian-Tian Zhang, Yang-Bo Zhang, Zhuo-Long Xie, Yuan Zhan, Ping Hu","doi":"10.1080/10286020.2024.2361767","DOIUrl":"https://doi.org/10.1080/10286020.2024.2361767","url":null,"abstract":"<p><p>Harmine is present in a variety of medicinal plants, and its effects on colon cancer cells remain unclear. Here, we found that harmine exhibited significant inhibitory effects on the proliferation of colon cancer cells by inhibiting the phosphorylation levels of the FAK/AKT and ERK1/2/CREB. Furthermore, harmine also inhibited the migration of colon cancer cells and suppressed the expression levels of MMP-2, MMP-9, and VEGF. Additionally, harmine-induced apoptosis in colon cancer cells by regulating the expression of Bcl-2 and Bax. In conclusion, our findings suggest that harmine exerts a significant inhibitory effect on the development of colon cancer cells.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141603631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diterpenoid alkaloids from Delphinium sherriffii. Delphinium sherriffii 的二萜生物碱。
IF 1.3 3区 医学 Q3 CHEMISTRY, APPLIED Pub Date : 2024-07-12 DOI: 10.1080/10286020.2024.2376244
Guo-Qing Sun, Cheng-En Fu, Yang Yang, Xiao-Jian Li, Jia-Yi Ma, Shuai Huang, Xian-Li Zhou, Lin Chen

Three new diterpenoid alkaloids (1, 2, 3) and seventeen known (4-20) compounds were isolated from the whole plant of Delphinium sherriffii Munz (Ranunculaceae). Their structures were elucidated by various spectroscopic analyses, including IR, HR-ESI-MS, 1D and 2D NMR spectra. All compounds were evaluated for the inhibitory activity of Sf9 cells and compound 5 exhibited the strongest cytotoxicity (IC50 = 8.97 μM) against Sf9 cell line.

从 Delphinium sherriffii Munz(毛茛科)全株中分离出三个新的二萜生物碱(1、2、3)和 17 个已知化合物(4-20)。通过各种光谱分析,包括红外光谱、HR-ESI-MS、一维和二维核磁共振光谱,阐明了这些化合物的结构。评估了所有化合物对 Sf9 细胞的抑制活性,其中化合物 5 对 Sf9 细胞株的细胞毒性最强(IC50 = 8.97 μM)。
{"title":"Diterpenoid alkaloids from <i>Delphinium sherriffii</i>.","authors":"Guo-Qing Sun, Cheng-En Fu, Yang Yang, Xiao-Jian Li, Jia-Yi Ma, Shuai Huang, Xian-Li Zhou, Lin Chen","doi":"10.1080/10286020.2024.2376244","DOIUrl":"https://doi.org/10.1080/10286020.2024.2376244","url":null,"abstract":"<p><p>Three new diterpenoid alkaloids (<b>1</b>, <b>2</b>, <b>3</b>) and seventeen known (<b>4-20</b>) compounds were isolated from the whole plant of <i>Delphinium sherriffii</i> Munz (Ranunculaceae). Their structures were elucidated by various spectroscopic analyses, including IR, HR-ESI-MS, 1D and 2D NMR spectra. All compounds were evaluated for the inhibitory activity of Sf9 cells and compound <b>5</b> exhibited the strongest cytotoxicity (IC<sub>50</sub> = 8.97 μM) against Sf9 cell line.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141599920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Schisandrin A can promote the anti-tumor effect of 5-Fu by reversing the immunosuppressive state of the body in rat. 五味子甲素可以通过逆转大鼠体内的免疫抑制状态来促进 5-Fu 的抗肿瘤作用。
IF 1.3 3区 医学 Q3 CHEMISTRY, APPLIED Pub Date : 2024-07-09 DOI: 10.1080/10286020.2024.2375291
Xiao-Hui Wang, Peng-Fei Dong, Feng Wang, Lin Zhou

In this study, based on Walker 256 in vitro experiments, CCK-8 assay, clone formation assay, wound healing assay, and flow cytometry were used to detect cell apoptosis and cell cycle. It was found that schisandrin may have significant anti-tumor effects in vitro by inhibiting TGF-β/Smad signaling pathway. In addition, in vivo experiments, immunohistochemistry was used to observe the expression of HIF-1α, VEGF and VEGFR-2 in tumor tissues. It was found that schisandrin could significantly improve the immunosuppression induced by 5-Fu and enhance the antitumor effect of 5-Fu. The mechanism may be related to the inhibition of Wnt-1/β-catenin signaling pathway.

本研究以 Walker 256 体外实验为基础,采用 CCK-8 试验、克隆形成试验、伤口愈合试验和流式细胞术检测细胞凋亡和细胞周期。结果发现,五味子甲素可通过抑制 TGF-β/Smad 信号通路在体外发挥显著的抗肿瘤作用。此外,在体内实验中,免疫组化法观察了肿瘤组织中 HIF-1α、VEGF 和 VEGFR-2 的表达。结果发现,五味子素能明显改善5-Fu诱导的免疫抑制,增强5-Fu的抗肿瘤作用。其机制可能与抑制Wnt-1/β-catenin信号通路有关。
{"title":"Schisandrin A can promote the anti-tumor effect of 5-Fu by reversing the immunosuppressive state of the body in rat.","authors":"Xiao-Hui Wang, Peng-Fei Dong, Feng Wang, Lin Zhou","doi":"10.1080/10286020.2024.2375291","DOIUrl":"https://doi.org/10.1080/10286020.2024.2375291","url":null,"abstract":"<p><p>In this study, based on Walker 256 in vitro experiments, CCK-8 assay, clone formation assay, wound healing assay, and flow cytometry were used to detect cell apoptosis and cell cycle. It was found that schisandrin may have significant anti-tumor effects in vitro by inhibiting TGF-β/Smad signaling pathway. In addition, in vivo experiments, immunohistochemistry was used to observe the expression of HIF-1α, VEGF and VEGFR-2 in tumor tissues. It was found that schisandrin could significantly improve the immunosuppression induced by 5-Fu and enhance the antitumor effect of 5-Fu. The mechanism may be related to the inhibition of Wnt-1/β-catenin signaling pathway.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141558838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chromomycins from soil-derived Streptomyces sp. inhibit the growth of human non-small cell lung cancer cells by targeting c-FLIP. 源自土壤的链霉菌的色霉素通过靶向 c-FLIP 抑制人类非小细胞肺癌细胞的生长。
IF 1.3 3区 医学 Q3 CHEMISTRY, APPLIED Pub Date : 2024-07-08 DOI: 10.1080/10286020.2024.2375288
Gao-Jie Li, Chen Wang, Wen-Die Wang, Yue Shang, Chao-Yang Zeng, Ai-Min Wang, Jing-Lin Bai, Jing Su, Ling Su, Shu-Yi Si, Li-Yan Yu, Mao-Luo Gan, Shu-Zhen Chen

Three chromomycin derivatives, chromomycins A3 (1, CA3), A5 (2, CA5), and monodeacetylchromomycin A3 (3, MDA-CA3), were identified from the soil-derived Streptomyces sp. CGMCC 26516. A reinvestigation of the structure of CA5 is reported, of which the absolute configuration was unambiguously determined for the first time to be identical with that of CA3 based on nuclear magnetic resonance (NMR) data analysis as well as NMR and electronic circular dichroism calculations. Compounds 1-3 showed potent cytotoxicity against the non-small-cell lung cancer (NSCLC) cells (A549, H460, H157-c-FLIP, and H157-LacZ) and down-regulated the protein expression of c-FLIP in A549 cells. The IC50 values of chromomycins in H157-c-FLIP were higher than that in H157-LacZ. Furthermore, si-c-FLIP promoted anti-proliferation effect of chromomycins in NSCLC cells. In nude mice xenograft model, 1 and 2 both showed more potent inhibition on the growth of H157-lacZ xenografts than that of H157-c-FLIP xenografts. These results verify that c-FLIP mediates the anticancer effects of chromomycins in NSCLC.

从源于土壤的链霉菌 CGMCC 26516 中鉴定出三种铬霉素衍生物,即铬霉素 A3(1,CA3)、A5(2,CA5)和单去乙酰铬霉素 A3(3,MDA-CA3)。报告对 CA5 的结构进行了重新研究,根据核磁共振数据分析以及核磁共振和电子圆二色性计算,首次明确确定其绝对构型与 CA3 相同。化合物1-3对非小细胞肺癌(NSCLC)细胞(A549、H460、H157-c-FLIP和H157-LacZ)具有很强的细胞毒性,并能下调A549细胞中c-FLIP的蛋白表达。铬霉素在H157-c-FLIP中的IC50值高于在H157-LacZ中的IC50值。此外,si-c-FLIP还能促进铬霉素在NSCLC细胞中的抗增殖作用。在裸鼠异种移植模型中,1和2对H157-lacZ异种移植细胞生长的抑制作用均强于H157-c-FLIP异种移植细胞。这些结果验证了c-FLIP介导了铬霉素在NSCLC中的抗癌作用。
{"title":"Chromomycins from soil-derived <i>Streptomyces</i> sp. inhibit the growth of human non-small cell lung cancer cells by targeting c-FLIP.","authors":"Gao-Jie Li, Chen Wang, Wen-Die Wang, Yue Shang, Chao-Yang Zeng, Ai-Min Wang, Jing-Lin Bai, Jing Su, Ling Su, Shu-Yi Si, Li-Yan Yu, Mao-Luo Gan, Shu-Zhen Chen","doi":"10.1080/10286020.2024.2375288","DOIUrl":"https://doi.org/10.1080/10286020.2024.2375288","url":null,"abstract":"<p><p>Three chromomycin derivatives, chromomycins A<sub>3</sub> (<b>1,</b> CA<sub>3</sub>), A<sub>5</sub> (<b>2,</b> CA<sub>5</sub>), and monodeacetylchromomycin A<sub>3</sub> (<b>3,</b> MDA-CA<sub>3</sub>), were identified from the soil-derived <i>Streptomyces</i> sp. CGMCC 26516. A reinvestigation of the structure of CA<sub>5</sub> is reported, of which the absolute configuration was unambiguously determined for the first time to be identical with that of CA<sub>3</sub> based on nuclear magnetic resonance (NMR) data analysis as well as NMR and electronic circular dichroism calculations. Compounds <b>1-3</b> showed potent cytotoxicity against the non-small-cell lung cancer (NSCLC) cells (A549, H460, H157-c-FLIP, and H157-LacZ) and down-regulated the protein expression of c-FLIP in A549 cells. The IC<sub>50</sub> values of chromomycins in H157-c-FLIP were higher than that in H157-LacZ. Furthermore, si-c-FLIP promoted anti-proliferation effect of chromomycins in NSCLC cells. In nude mice xenograft model, <b>1</b> and <b>2</b> both showed more potent inhibition on the growth of H157-lacZ xenografts than that of H157-c-FLIP xenografts. These results verify that c-FLIP mediates the anticancer effects of chromomycins in NSCLC.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141554886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Journal of Asian Natural Products Research
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1