Pub Date : 2025-12-02DOI: 10.1080/10286020.2025.2492355
Xin-Yang Liu , Jing-Jing Zhang , Qian-Qian Yin , Yan-Ping Zhang , Chen Zhao , Ming-Xia Fang , Qing-Qi Meng , Yue Hou , Di Zhou , Ning Li
Eleven compounds were isolated from the n-butanol extract of Aglaia odorata Lour, including one undescribed lignan, curlignan-4-O-β-D-glucopyranoside (1), and ten known compounds (2–11). Their structures were characterized by comprehensive spectral analysis, nuclear magnetic resonance (1D and 2D NMR), mass spectrometry (MS), and electronic circular dichroism (ECD). The inhibitory effects of these compounds on nitric oxide (NO) production in lipopolysaccharide (LPS) stimulated BV-2 microglia were evaluated. The experimental results indicated that the anti-neuroinflammatory activities of compounds 1, 3, 4, 6, 7, 9 and 10 were significantly better than those of the positive control minocycline (IC50 = 41.34 ± 3.55 μM), with IC50 values ranging from 1.31 to 15.70 μM.
{"title":"Natural anti-neuroinflammatory inhibitors from Aglaia odorata","authors":"Xin-Yang Liu , Jing-Jing Zhang , Qian-Qian Yin , Yan-Ping Zhang , Chen Zhao , Ming-Xia Fang , Qing-Qi Meng , Yue Hou , Di Zhou , Ning Li","doi":"10.1080/10286020.2025.2492355","DOIUrl":"10.1080/10286020.2025.2492355","url":null,"abstract":"<div><div>Eleven compounds were isolated from the <em>n</em>-butanol extract of <em>Aglaia odorata</em> Lour, including one undescribed lignan, curlignan-4-<em>O</em>-<em>β</em>-D-glucopyranoside (<strong>1</strong>), and ten known compounds (<strong>2–11</strong>). Their structures were characterized by comprehensive spectral analysis, nuclear magnetic resonance (1D and 2D NMR), mass spectrometry (MS), and electronic circular dichroism (ECD). The inhibitory effects of these compounds on nitric oxide (NO) production in lipopolysaccharide (LPS) stimulated BV-2 microglia were evaluated. The experimental results indicated that the anti-neuroinflammatory activities of compounds <strong>1, 3, 4, 6, 7, 9</strong> and <strong>10</strong> were significantly better than those of the positive control minocycline (IC<sub>50</sub> = 41.34 ± 3.55 μM), with IC<sub>50</sub> values ranging from 1.31 to 15.70 μM.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 12","pages":"Pages 1799-1806"},"PeriodicalIF":1.3,"publicationDate":"2025-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144007938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-02DOI: 10.1080/10286020.2024.2311149
Yu-Jue Wang , Xin-Ye Wang , Zi-Nuo Yang , Xin-Yue Shang , Si-Hui Mi , Qingbo Liu , Guo-Dong Yao , Shao-Jiang Song
Gastric cancer is one of the common malignant tumors. It is reported that daphne-type diterpenes have inhibitory effects on gastric cancer cells, but the mechanism is still unknown. To explore the detailed mechanism of the anticancer effect of daphne-type diterpenes, we carried out an integrated network pharmacology prediction study and selected an effective component (yuanhuacine, YHC) for the following validation in silico and in vitro. The result showed that daphne-type diterpenes exerted an anti-tumor effect by targeting proto-oncogene tyrosine-protein kinase SRC as well as regulating the Ras/MAPK signaling pathway, which caused the apoptosis and mitochondrial damage in gastric cancer cells.
{"title":"Exploring the mechanism of daphne-type diterpenes against gastric cancer cells","authors":"Yu-Jue Wang , Xin-Ye Wang , Zi-Nuo Yang , Xin-Yue Shang , Si-Hui Mi , Qingbo Liu , Guo-Dong Yao , Shao-Jiang Song","doi":"10.1080/10286020.2024.2311149","DOIUrl":"10.1080/10286020.2024.2311149","url":null,"abstract":"<div><div>Gastric cancer is one of the common malignant tumors. It is reported that daphne-type diterpenes have inhibitory effects on gastric cancer cells, but the mechanism is still unknown. To explore the detailed mechanism of the anticancer effect of daphne-type diterpenes, we carried out an integrated network pharmacology prediction study and selected an effective component (yuanhuacine, YHC) for the following validation <em>in silico</em> and <em>in vitro</em>. The result showed that daphne-type diterpenes exerted an anti-tumor effect by targeting proto-oncogene tyrosine-protein kinase SRC as well as regulating the Ras/MAPK signaling pathway, which caused the apoptosis and mitochondrial damage in gastric cancer cells.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 12","pages":"Pages 1836-1848"},"PeriodicalIF":1.3,"publicationDate":"2025-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139722780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-02DOI: 10.1080/10286020.2024.2302825
Jing-Ru Fang , Yu-Jie Zhang , Xiao Meng , Yi Chen , Xue Zhang , Ling-Juan Zhu , Xin-Sheng Yao
Rauvolfia dichotoma, a shrub of Apocynaceae, was collected from the Islands of SAO Tome and Principe and cultivated locally for medicinal purpose. Phytochemical investigation of 95% ethanol extract from the stems and leaves of R. dichotoma led to the isolation of two new Nb-oxide indole alkaloids, namely Nb-oxide-mitoridine (1) and Nb-oxide-raucaffricine (2), together with two known alkaloids (3–4) and eleven known lignans (5–15). Their chemical structures were elucidated by extensive NMR and HR-ESI-MS data analysis. All compounds (except 13) were tested for their β-hematin inhibitory activity. Compounds 2, 4, 14, and 15 showed certain inhibitory activity, indicating that they may have an antimalarial effect.
{"title":"Two new Nb-oxide indole alkaloids with β-hematin inhibitory activity from the stems and leaves of Rauvolfia dichotoma","authors":"Jing-Ru Fang , Yu-Jie Zhang , Xiao Meng , Yi Chen , Xue Zhang , Ling-Juan Zhu , Xin-Sheng Yao","doi":"10.1080/10286020.2024.2302825","DOIUrl":"10.1080/10286020.2024.2302825","url":null,"abstract":"<div><div><em>Rauvolfia dichotoma</em>, a shrub of Apocynaceae, was collected from the Islands of SAO Tome and Principe and cultivated locally for medicinal purpose. Phytochemical investigation of 95% ethanol extract from the stems and leaves of <em>R. dichotoma</em> led to the isolation of two new <em>N</em><sub>b</sub>-oxide indole alkaloids, namely <em>N</em><sub>b</sub>-oxide-mitoridine (<strong>1</strong>) and <em>N</em><sub>b</sub>-oxide-raucaffricine (<strong>2</strong>), together with two known alkaloids (<strong>3–4</strong>) and eleven known lignans (<strong>5–15</strong>). Their chemical structures were elucidated by extensive NMR and HR-ESI-MS data analysis. All compounds (except <strong>13</strong>) were tested for their <em>β-</em>hematin inhibitory activity. Compounds <strong>2</strong>, <strong>4</strong>, <strong>14,</strong> and <strong>15</strong> showed certain inhibitory activity, indicating that they may have an antimalarial effect.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 12","pages":"Pages 1749-1757"},"PeriodicalIF":1.3,"publicationDate":"2025-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139512561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Two new aporphine alkaloids, 6aR-2'-(3-oxobutenyl)-thaliadin (1) and N-methylthalisopynine (2), along with ten known analogs (3–12), were isolated from the roots of Thalictrum omeiense W. T. Wang et S. H. Wang. Their structures were determined by extensive spectroscopic and X-ray crystallographic analyses. Compounds 1–7 and 9–12 were tested for their antiproliferative effects in vitro against two human cancer cell lines (A549 and MCF-7). Among them, compounds 1, 3, and 7 exhibited moderate inhibitory activity against the tested cell lines with IC50 values ranging from 23.73 to 34.97 μM.
从 Thalictrum omeiense W. T. Wang et S. H. Wang 的根中分离出两种新的卟吩生物碱，6aR-2'-(3-氧代丁烯基)-thaliadin (1) 和 N-methylthalisopynine (2)，以及十种已知的类似物 (3-12)。通过大量光谱和 X 射线晶体分析确定了它们的结构。体外测试了化合物 1-7 和 9-12 对两种人类癌细胞株（A549 和 MCF-7）的抗增殖作用。其中，化合物 1、3 和 7 对所测试的细胞株具有中等程度的抑制活性，IC50 值介于 23.73 到 34.97 μM 之间。
{"title":"New aporphine alkaloids with antitumor activities from the roots of Thalictrum omeiense","authors":"Zhao-Jing Chen , Han-Gao Yang , Wen-Peng Zhu , Chun-Mei Xue , Hong-Mei Zhang , Yu-Ting Peng , Da-Hong Li , Hui-Ming Hua","doi":"10.1080/10286020.2024.2317826","DOIUrl":"10.1080/10286020.2024.2317826","url":null,"abstract":"<div><div>Two new aporphine alkaloids, 6a<em>R</em>-2'-(3-oxobutenyl)-thaliadin (<strong>1</strong>) and <em>N</em>-methylthalisopynine (<strong>2</strong>), along with ten known analogs (<strong>3</strong>–<strong>12</strong>), were isolated from the roots of <em>Thalictrum omeiense</em> W. T. Wang et S. H. Wang. Their structures were determined by extensive spectroscopic and X-ray crystallographic analyses. Compounds <strong>1</strong>–<strong>7</strong> and <strong>9</strong>–<strong>12</strong> were tested for their antiproliferative effects <em>in vitro</em> against two human cancer cell lines (A549 and MCF-7). Among them, compounds <strong>1</strong>, <strong>3,</strong> and <strong>7</strong> exhibited moderate inhibitory activity against the tested cell lines with IC<sub>50</sub> values ranging from 23.73 to 34.97 μM.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 12","pages":"Pages 1777-1785"},"PeriodicalIF":1.3,"publicationDate":"2025-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139931329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-02DOI: 10.1080/10286020.2024.2335279
Zhi-Yong Xu , Ning-Ning Du , Chang-Sheng La , Xiao-Xiao Huang , Shao-Jiang Song
Two pairs of cyclohexene amide alkaloid enantiomers were obtained from the root of Piper nigrum. Their plane structures were established by NMR and HRESIMS spectra. The absolute configurations of 1a/1b and 2a/2b were determined by the comparison between the experimental and calculated electronic circular dichroism (ECD) spectra. All identified compounds were tested for inhibitory effects on acetylcholinesterase (AChE) in vitro. Notably, compounds 1b and 2b showed strong inhibitory effects on AChE and the interaction between proteins and compounds was discussed by molecular docking studies.
{"title":"Two pairs of bioactive cyclohexene alkaloid enantiomers from the roots of Piper nigrum","authors":"Zhi-Yong Xu , Ning-Ning Du , Chang-Sheng La , Xiao-Xiao Huang , Shao-Jiang Song","doi":"10.1080/10286020.2024.2335279","DOIUrl":"10.1080/10286020.2024.2335279","url":null,"abstract":"<div><div>Two pairs of cyclohexene amide alkaloid enantiomers were obtained from the root of <em>Piper nigrum</em>. Their plane structures were established by NMR and HRESIMS spectra. The absolute configurations of <strong>1a/1b</strong> and <strong>2a/2b</strong> were determined by the comparison between the experimental and calculated electronic circular dichroism (ECD) spectra. All identified compounds were tested for inhibitory effects on acetylcholinesterase (AChE) <em>in vitro</em>. Notably, compounds <strong>1b</strong> and <strong>2b</strong> showed strong inhibitory effects on AChE and the interaction between proteins and compounds was discussed by molecular docking studies.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 12","pages":"Pages 1739-1748"},"PeriodicalIF":1.3,"publicationDate":"2025-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140570674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-02DOI: 10.1080/10286020.2024.2325033
Jia-Yi Li , Xin-Yi Wang , Mei-Juan Han , Ming Bai , Xiao-Xiao Huang
Guiding by LC-MS/MS analysis and the Global Natural Products Social (GNPS) Molecular Networking, three undescribed sesquiterpenoids, stedapgens A–C, and two known analogues were discovered in the barks of Daphne genkwa Sieb. et Zucc. The structures were determined by analysis of their spectroscopic data and quantum-chemical calculations. All the isolated novel compounds were tested for their acetylcholinesterase inhibitory activities with IC50 = 0.754 ± 0.059, 0.696 ± 0.026, and 0.337 ± 0.023 μg/ml. Among them, stedapgen A displayed promising inhibitory activities against AChE, and the binding sites were predicted by molecular docking.
{"title":"Target isolation of diverse sesquiterpenoid from the stems of Daphne genkwa based on molecular networking","authors":"Jia-Yi Li , Xin-Yi Wang , Mei-Juan Han , Ming Bai , Xiao-Xiao Huang","doi":"10.1080/10286020.2024.2325033","DOIUrl":"10.1080/10286020.2024.2325033","url":null,"abstract":"<div><div>Guiding by LC-MS/MS analysis and the Global Natural Products Social (GNPS) Molecular Networking, three undescribed sesquiterpenoids, stedapgens A–C, and two known analogues were discovered in the barks of <em>Daphne genkwa</em> Sieb. et Zucc. The structures were determined by analysis of their spectroscopic data and quantum-chemical calculations. All the isolated novel compounds were tested for their acetylcholinesterase inhibitory activities with IC<sub>50</sub> = 0.754 ± 0.059, 0.696 ± 0.026, and 0.337 ± 0.023 <em>μ</em>g/ml. Among them, stedapgen A displayed promising inhibitory activities against AChE, and the binding sites were predicted by molecular docking.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 12","pages":"Pages 1807-1818"},"PeriodicalIF":1.3,"publicationDate":"2025-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140287496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-02DOI: 10.1080/10286020.2024.2360640
Yue-Lin Zhao , Yue Jin , Zi-Ying Han , Wen-Han Song , Hui-Lin Zhu , Jian Zhang , Qian Wang , Miao Wang , Xiao-Wen Jiang , Hui-Yuan Gao
In this study, a previously undescribed cassane diterpenoid, named caesalpinin JF (1), along with two known cassane diterpenoids caesanine C (2) and tomocinol B (3), was isolated from 95% EtOH extract of the seeds of Caesalpinia sappan Linn. Additionally, three known compounds including pulcherrin R (4), syringaresinol-4'-O-β-D-glucopyranoside (5) and kaempferol (6) were also identified. The structures of the isolated compounds were elucidated by comprehensive 1D and 2D NMR spectroscopic analyses. Additionally, electronic circular dichroism (ECD) calculation was used to identify the absolute structure of compound 1. Among the isolated compounds, compound 1 displayed a potent anti-neuroinflammation with an IC50 value of 9.87 ± 1.71 μM.
在这项研究中，从红豆杉种子 95% 的 EtOH 提取物中分离出了一种之前未曾描述过的决明子二萜，命名为 Caesalpinin JF (1)，以及两种已知的决明子二萜 caesanine C (2) 和 tomocinol B (3)。此外，还鉴定出三种已知化合物，包括 Pulcherrin R (4)、Syringaresinol-4'-O-β-D-吡喃葡萄糖苷 (5) 和山奈酚 (6)。通过全面的一维和二维核磁共振光谱分析，阐明了这些分离化合物的结构。在分离出的化合物中，化合物 1 具有很强的抗神经发炎作用，其 IC50 值为 9.87 ± 1.71 μM。
{"title":"A new cassane diterpenoid from the seed of Caesalpinia sappan","authors":"Yue-Lin Zhao , Yue Jin , Zi-Ying Han , Wen-Han Song , Hui-Lin Zhu , Jian Zhang , Qian Wang , Miao Wang , Xiao-Wen Jiang , Hui-Yuan Gao","doi":"10.1080/10286020.2024.2360640","DOIUrl":"10.1080/10286020.2024.2360640","url":null,"abstract":"<div><div>In this study, a previously undescribed cassane diterpenoid, named caesalpinin JF (<strong>1</strong>), along with two known cassane diterpenoids caesanine C (<strong>2</strong>) and tomocinol B (<strong>3</strong>), was isolated from 95% EtOH extract of the seeds of <em>Caesalpinia sappan</em> Linn. Additionally, three known compounds including pulcherrin R (<strong>4</strong>), syringaresinol-4'-<em>O</em>-<em>β</em>-D-glucopyranoside (<strong>5</strong>) and kaempferol (<strong>6</strong>) were also identified. The structures of the isolated compounds were elucidated by comprehensive 1D and 2D NMR spectroscopic analyses. Additionally, electronic circular dichroism (ECD) calculation was used to identify the absolute structure of compound <strong>1</strong>. Among the isolated compounds, compound <strong>1</strong> displayed a potent anti-neuroinflammation with an IC<sub>50</sub> value of 9.87 ± 1.71 <em>μ</em>M.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 12","pages":"Pages 1792-1798"},"PeriodicalIF":1.3,"publicationDate":"2025-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141468142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-02DOI: 10.1080/10286020.2024.2327524
Xiang Gao , Hao-Nan Li , Peng-Ju Liu , Xiao-Kang Long , Xue-Hai Guo , Hui-Ming Hua , Da-Hong Li
In recent years, with sinomenine hydrochloride as the main ingredient, Qingfengteng had been formulated as various dosage forms for clinical treatment. Subsequent findings confirmed a variety of biological roles for sinomenine. Here, 15 H2S-donating sinomenine derivatives were synthesized. Target hybrids a11 displayed substantial cytotoxic effects on cancer cell lines, particularly against K562 cells, with an IC50 value of 1.36 μM. In-depth studies demonstrated that a11 arrested cell cycle at G1 phase, induced apoptosis via both morphological changes in nucleus and membrane potential collapse in mitochondria. These results indicated a11 exerted an antiproliferative effect through apoptosis induction via mitochondrial pathway.
{"title":"Synthesis of sinomenine derivatives with potential anti-leukemia activity","authors":"Xiang Gao , Hao-Nan Li , Peng-Ju Liu , Xiao-Kang Long , Xue-Hai Guo , Hui-Ming Hua , Da-Hong Li","doi":"10.1080/10286020.2024.2327524","DOIUrl":"10.1080/10286020.2024.2327524","url":null,"abstract":"<div><div>In recent years, with sinomenine hydrochloride as the main ingredient, Qingfengteng had been formulated as various dosage forms for clinical treatment. Subsequent findings confirmed a variety of biological roles for sinomenine. Here, 15 H<sub>2</sub>S-donating sinomenine derivatives were synthesized. Target hybrids <strong>a11</strong> displayed substantial cytotoxic effects on cancer cell lines, particularly against K562 cells, with an IC<sub>50</sub> value of 1.36 μM. In-depth studies demonstrated that <strong>a11</strong> arrested cell cycle at G1 phase, induced apoptosis <em>via</em> both morphological changes in nucleus and membrane potential collapse in mitochondria. These results indicated <strong>a11</strong> exerted an antiproliferative effect through apoptosis induction <em>via</em> mitochondrial pathway.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 12","pages":"Pages 1819-1835"},"PeriodicalIF":1.3,"publicationDate":"2025-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140593511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-02DOI: 10.1080/10286020.2024.2317841
Lian Lian , Yue-Lin Zhao , Tian-Jian Zhang , Miao Wang , Hui-Yuan Gao
Two new cassane diterpenoids, sucupiranin MN (1) and sucupiranin ML (2), together with two known compounds sucutinirane C (3) and deacetylsucutinirane C (4) were isolated from the seed kernels of Caesalpinia sinensis. Their structures were elucidated by means of analysis of comprehensive spectroscopic data, especially HRESIMS and 1D/2D NMR spectroscopy. Compounds 1–4 are typical furan-type cassane derivatives with an aromatized C ring. Biological evaluation revealed that compounds 1–4 at the concentration of 10 μM could inhibit the overproduction of NO in LPS-stimulated RAW 264.7 macrophages.
从中华皂荚的种仁中分离出了两种新的皂荚烷二萜类化合物：琥珀烷宁 MN (1) 和琥珀烷宁 ML (2)，以及两种已知化合物琥珀烷宁 C (3) 和脱乙酰基琥珀烷宁 C (4)。通过分析全面的光谱数据，特别是 HRESIMS 和 1D/2D NMR 光谱，阐明了它们的结构。化合物 1-4 是具有芳香化 C 环的典型呋喃型卡桑烷衍生物。生物学评价显示，浓度为 10 μM 的化合物 1-4 可抑制 LPS 刺激的 RAW 264.7 巨噬细胞中 NO 的过度产生。
{"title":"Two new cassane diterpenoids from the seed kernels of Caesalpinia sinensis","authors":"Lian Lian , Yue-Lin Zhao , Tian-Jian Zhang , Miao Wang , Hui-Yuan Gao","doi":"10.1080/10286020.2024.2317841","DOIUrl":"10.1080/10286020.2024.2317841","url":null,"abstract":"<div><div>Two new cassane diterpenoids, sucupiranin MN (<strong>1</strong>) and sucupiranin ML (<strong>2</strong>), together with two known compounds sucutinirane C (<strong>3</strong>) and deacetylsucutinirane C (<strong>4</strong>) were isolated from the seed kernels of <em>Caesalpinia sinensis</em>. Their structures were elucidated by means of analysis of comprehensive spectroscopic data, especially HRESIMS and 1D/2D NMR spectroscopy. Compounds <strong>1–4</strong> are typical furan-type cassane derivatives with an aromatized C ring. Biological evaluation revealed that compounds <strong>1–4</strong> at the concentration of 10 μM could inhibit the overproduction of NO in LPS-stimulated RAW 264.7 macrophages.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 12","pages":"Pages 1786-1791"},"PeriodicalIF":1.3,"publicationDate":"2025-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139996275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01Epub Date: 2025-11-17DOI: 10.1080/10286020.2025.2588076
Shao-Jiang Song
{"title":"Special issue commemorating the 40th anniversary of the College of Traditional Chinese Medicine, Shenyang Pharmaceutical University.","authors":"Shao-Jiang Song","doi":"10.1080/10286020.2025.2588076","DOIUrl":"10.1080/10286020.2025.2588076","url":null,"abstract":"","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1737-1738"},"PeriodicalIF":1.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145534295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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