Journal of Asian Natural Products Research最新文献

Chemical investigation of the edible roots of Codonopsis pilosula yielded a new lignan (1), together with twenty-nine known compounds, including twenty-one lignans (2-22) and eight phenylpropanoids (23-30). The structure of the new lignan, including its absolute configuration, was determined using a combination of extensive spectroscopic analysis, NMR and ECD calculations, and comparison with literature values. The isolated lignans and phenylpropanoids (excluding 1, 20, 21 and 28) were evaluated for their antioxidant activities using ABTS and DPPH radical scavenging assays. Among them, compounds 2-6, 18 and 23 exhibited strong scavenging activities in ABTS and DPPH assays with SC₅₀ values ranging from 9.73 to 47.26 μM compared with the positive control L-ascorbic acid.

Renal fibrosis is a global health challenge with limited therapies. 7-O-methyesculin (7-ME), derived from Cortex Fraxini (Qinpi), shows notable anti-inflammatory and anti-fibrotic properties. To enhance its membrane permeability and biological activity, we performed structural optimization and synthesized 18 6'-O-acyl 7-ME esters to improve lipophilicity and efficacy. Most derivatives displayed significant anti-fibrotic effects. Among them, EA-8 and EA-10 were more active than 7-ME against key fibrosis markers, including α-SMA, fibronectin and P-Smad3, while upregulating the protective protein E-cadherin. Mechanistic studies indicated that these compounds suppress the TGF-β1/Smad3 signaling pathway, providing a promising strategy for developing effective anti-fibrotic therapeutics.

ALI is a severe clinical syndrome with limited treatment options beyond corticosteroids, which cause significant adverse effects. This study demonstrates that the herbal combination EAC significantly attenuates LPS-induced ALI through dual pathway inhibition. EAC suppresses TLR4/NF-κB and NLRP3 inflammasome signaling, thereby inhibiting MyD88-mediated NF-κB activation, NLRP3 inflammasome assembly, caspase-1 activation, and GSDMD-|mediated pyroptosis. Consequently, EAC reduces proinflammatory cytokine production (IL-1β, IL-18) and restores the balance between inflammatory and anti-inflammatory responses, offering a promising therapeutic alternative to conventional corticosteroids for ALI treatment.

10-Methoxycamptothecin (MCPT), a natural camptothecin derivative, shows notable anticancer activity. Using UPLC-QTOF-MS, this study characterized MCPT metabolite profiles in rats, detecting 14 metabolites in urine, 5 in bile, 7 in feces, and 2 in plasma. The findings indicated that phase I metabolites of MCPT were primarily formed via demethylation, demethoxylation, and hydroxylation, while phase II metabolites mainly included glucuronide and sulfate of MCPT and its phase I metabolites. MCPT, hydroxycamptothecin, and the subsequent glucuronide conjugates were the predominant forms of MCPT in rats. This study provided a comprehensive overview of the metabolite profile of MCPT in rats.

In this research, HS-CoFe₂O₄/Cu(ΙΙ) has been synthesized as a novel, natural based and recoverable magnetic composite with high catalytic activity. The structure of this magnetic natural based catalyst was investigated and approved using various analytical tools such as FT-IR, EDX-map, X-ray diffraction (XRD), VSM and FE-SEM. Among the advantages of the developed catalyst, one can point to compatibility with the environment, easy preparation and separation, reusability and low production cost. According to the principles of green chemistry, this study seeks to highlight the possibility of applying renewable and cheap materials and preparing catalysts with waste materials. The synthesized HS-CoFe₂O₄/Cu(ΙΙ) has shown high catalytic activity for the preparation of bis(indolyl)methane and dihydropyrano[2,3-c]pyrazole derivatives.