Pub Date : 2024-07-08DOI: 10.1080/10286020.2024.2373326
Jiang Hu, Ren Ji, Guang-Rong Yang, Tao Lv, Qiang Li, Feng Gao
A chemical investigation on the roots of Aconitum nagarum afforded two undescribed C19-diterpenoid alkaloids nagarumines D and E (1 and 2). The structures of the new compounds were elucidated by spectral methods such as 1D and 2D (1H-1H COSY, HMQC, and HMBC) NMR spectroscopy, as well as HR-ESI-MS. The two isolated alkaloids were tested in vitro for cytotoxic activity against five gastric tumor cell lines. Consequently, compound 2 exhibited some cytotoxicities against several human cancer cell lines with IC50 value less than 20.0 μM.
{"title":"Two new diterpenoid alkaloids from the roots of <i>Aconitum nagarum</i> and their cytotoxic activity.","authors":"Jiang Hu, Ren Ji, Guang-Rong Yang, Tao Lv, Qiang Li, Feng Gao","doi":"10.1080/10286020.2024.2373326","DOIUrl":"https://doi.org/10.1080/10286020.2024.2373326","url":null,"abstract":"<p><p>A chemical investigation on the roots of <i>Aconitum nagarum</i> afforded two undescribed C<sub>19</sub>-diterpenoid alkaloids nagarumines D and E (<b>1</b> and <b>2</b>). The structures of the new compounds were elucidated by spectral methods such as 1D and 2D (<sup>1</sup>H-<sup>1</sup>H COSY, HMQC, and HMBC) NMR spectroscopy, as well as HR-ESI-MS. The two isolated alkaloids were tested <i>in vitro</i> for cytotoxic activity against five gastric tumor cell lines. Consequently, compound <b>2</b> exhibited some cytotoxicities against several human cancer cell lines with IC<sub>50</sub> value less than 20.0 μM.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-7"},"PeriodicalIF":1.3,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141554888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-04DOI: 10.1080/10286020.2024.2364908
Two new cucurbitane-type triterpenoid saponins, 2,20β,22β-trihydroxy-16α,23(R)-epoxycucurbita-1,5,24-triene-3,11-dione 2-O-β-D-glucopyranoside (1), 2,20β,22α-trihydroxy-16α,23(S)-epoxycucurbita-1,5,11,24-tetraene-3-one 2-O-β-D-glucopyranoside (2) were isolated from the fruit of Citrullus colocynthis (L.) Schrad. Their structures were elucidated by mass spectrometry, IR, 1D, and 2D NMR spectroscopy, etc. Besides, both of the compounds showed significant hepatoprotective activities at 10 μM against paracetamol-induced HepG2 cell damage.
{"title":"Two new cucurbitane-type triterpenoid saponins from the fruit of Citrullus colocynthis","authors":"","doi":"10.1080/10286020.2024.2364908","DOIUrl":"10.1080/10286020.2024.2364908","url":null,"abstract":"<div><div>Two new cucurbitane-type triterpenoid saponins, 2,20<em>β</em>,22<em>β</em>-trihydroxy-16<em>α</em>,23(<em>R</em>)-epoxycucurbita-1,5,24-triene-3,11-dione 2-<em>O</em>-<em>β</em>-D-glucopyranoside (<strong>1</strong>), 2,20<em>β</em>,22<em>α</em>-trihydroxy-16<em>α</em>,23(<em>S</em>)-epoxycucurbita-1,5,11,24-tetraene-3-one 2-<em>O</em>-<em>β</em>-D-glucopyranoside (<strong>2</strong>) were isolated from the fruit of <em>Citrullus colocynthis</em> (L.) Schrad. Their structures were elucidated by mass spectrometry, IR, 1D, and 2D NMR spectroscopy, etc. Besides, both of the compounds showed significant hepatoprotective activities at 10 <em>μ</em>M against paracetamol-induced HepG2 cell damage.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"26 11","pages":"Pages 1320-1327"},"PeriodicalIF":1.3,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141503000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fuzheng Huayu recipe (FZHYR) is a Chinese patent medicine for the treatment of fibrosis. The effects of FZHYR on pulmonary fibrosis and macrophage polarization were investigated in vitro. FZHYR inhibited pulmonary inflammation and fibrosis and M2 polarization of macrophages in bleomycin-induced pulmonary fibrosis (BPF) of rat model. Differentially expressed genes were screened by high-throughput mRNA sequencing and GSEA showed that oxidative phosphorylation (OXPHOS) was correlated with BPF. FZHYR inhibited expressions of Ndufa2 and Ndufa6 in lung tissues of BPF rats. These findings suggest that OXPHOS pathway serves as a possible target for pulmonary fibrosis therapy by FZHYR.
{"title":"Fuzheng Huayu recipe inhibits bleomycin-induced pulmonary fibrosis in rats by inhibiting M2 polarization of macrophages via the oxidative phosphorylation pathway.","authors":"Xing-Hua Yuan, Su-Fang Zhang, Yu Hang, Yan-Hua Shen, Shan-Fang Zhang, Wei-Ling Huang, Jing-Yi Huang, Ye-Chang Qian, Xiu-Lian Zhang, Qiu-Hong Li, Li Li","doi":"10.1080/10286020.2024.2371050","DOIUrl":"10.1080/10286020.2024.2371050","url":null,"abstract":"<p><p>Fuzheng Huayu recipe (FZHYR) is a Chinese patent medicine for the treatment of fibrosis. The effects of FZHYR on pulmonary fibrosis and macrophage polarization were investigated <i>in vitro</i>. FZHYR inhibited pulmonary inflammation and fibrosis and M2 polarization of macrophages in bleomycin-induced pulmonary fibrosis (BPF) of rat model. Differentially expressed genes were screened by high-throughput mRNA sequencing and GSEA showed that oxidative phosphorylation (OXPHOS) was correlated with BPF. FZHYR inhibited expressions of <i>Ndufa2</i> and <i>Ndufa6</i> in lung tissues of BPF rats. These findings suggest that OXPHOS pathway serves as a possible target for pulmonary fibrosis therapy by FZHYR.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-13"},"PeriodicalIF":1.3,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141492123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Boswellia sacra has the properties of activating blood circulation, fixing pain, subduing swelling and promoting muscle growth. However, the anti-inflammatory active ingredients and molecular mechanisms of Boswellia sacra are still not clearly explored. Boswellia sacra was grounded and extracted using 95% ethanol, the extracts were separated by column chromatography preparation to give compounds. Spectral analysis and quantum calculations confirmed the structures of compounds and identified compound 1 as a new compound. Compounds 1-3 showed potent inhibitory activities and their effects on inflammatory mediator NO and inflammatory cytokines were examined by ELISA assay. Furthermore, their modulatory mechanism on inflammatory signal pathways was explored.
乳香具有活血、止痛、消肿和促进肌肉生长的功效。然而，乳香的抗炎活性成分和分子机制仍未得到明确的探索。将乳香磨碎并用 95% 的乙醇提取，提取物经柱层析分离得到化合物。光谱分析和量子计算证实了化合物的结构，并确定化合物 1 为新化合物。通过酶联免疫吸附试验检测了化合物 1-3 对炎症介质 NO 和炎症细胞因子的影响。此外，还探讨了它们对炎症信号通路的调节机制。
{"title":"New cembranoid with potent anti-inflammatory effect isolated from <i>Boswellia sacra</i> by inactivating the NF-κB signaling pathway.","authors":"Xiao-Rong Yin, Zhen Yuan, Wei-Feng Wang, Bing-Yang Zhang, Lu-Qiong Wang, Feng Qiu, Feng Zhao","doi":"10.1080/10286020.2024.2372390","DOIUrl":"https://doi.org/10.1080/10286020.2024.2372390","url":null,"abstract":"<p><p><i>Boswellia sacra</i> has the properties of activating blood circulation, fixing pain, subduing swelling and promoting muscle growth. However, the anti-inflammatory active ingredients and molecular mechanisms of <i>Boswellia sacra</i> are still not clearly explored. <i>Boswellia sacra</i> was grounded and extracted using 95% ethanol, the extracts were separated by column chromatography preparation to give compounds. Spectral analysis and quantum calculations confirmed the structures of compounds and identified compound <b>1</b> as a new compound. Compounds <b>1</b>-<b>3</b> showed potent inhibitory activities and their effects on inflammatory mediator NO and inflammatory cytokines were examined by ELISA assay. Furthermore, their modulatory mechanism on inflammatory signal pathways was explored.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-18"},"PeriodicalIF":1.3,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141492124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01Epub Date: 2024-03-28DOI: 10.1080/10286020.2024.2334547
{"title":"Correction.","authors":"","doi":"10.1080/10286020.2024.2334547","DOIUrl":"10.1080/10286020.2024.2334547","url":null,"abstract":"","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"865"},"PeriodicalIF":1.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140305781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In this study, a previously undescribed cassane diterpenoid, named caesalpinin JF (1), along with two known cassane diterpenoids caesanine C (2) and tomocinol B (3), was isolated from 95% EtOH extract of the seeds of Caesalpinia sappan Linn. Additionally, three known compounds including pulcherrin R (4), syringaresinol-4'-O-β-D-glucopyranoside (5) and kaempferol (6) were also identified. The structures of the isolated compounds were elucidated by comprehensive 1D and 2D NMR spectroscopic analyses. Additionally, electronic circular dichroism (ECD) calculation was used to identify the absolute structure of compound 1. Among the isolated compounds, compound 1 displayed a potent anti-neuroinflammation with an IC50 value of 9.87 ± 1.71 μM.
在这项研究中，从红豆杉种子 95% 的 EtOH 提取物中分离出了一种之前未曾描述过的决明子二萜，命名为 Caesalpinin JF (1)，以及两种已知的决明子二萜 caesanine C (2) 和 tomocinol B (3)。此外，还鉴定出三种已知化合物，包括 Pulcherrin R (4)、Syringaresinol-4'-O-β-D-吡喃葡萄糖苷 (5) 和山奈酚 (6)。通过全面的一维和二维核磁共振光谱分析，阐明了这些分离化合物的结构。在分离出的化合物中，化合物 1 具有很强的抗神经发炎作用，其 IC50 值为 9.87 ± 1.71 μM。
{"title":"A new cassane diterpenoid from the seed of <i>Caesalpinia sappan</i>.","authors":"Yue-Lin Zhao, Yue Jin, Zi-Ying Han, Wen-Han Song, Hui-Lin Zhu, Jian Zhang, Qian Wang, Miao Wang, Xiao-Wen Jiang, Hui-Yuan Gao","doi":"10.1080/10286020.2024.2360640","DOIUrl":"https://doi.org/10.1080/10286020.2024.2360640","url":null,"abstract":"<p><p>In this study, a previously undescribed cassane diterpenoid, named caesalpinin JF (<b>1</b>), along with two known cassane diterpenoids caesanine C (<b>2</b>) and tomocinol B (<b>3</b>), was isolated from 95% EtOH extract of the seeds of <i>Caesalpinia sappan</i> Linn. Additionally, three known compounds including pulcherrin R (<b>4</b>), syringaresinol-4'-<i>O</i>-<i>β</i>-D-glucopyranoside (<b>5</b>) and kaempferol (<b>6</b>) were also identified. The structures of the isolated compounds were elucidated by comprehensive 1D and 2D NMR spectroscopic analyses. Additionally, electronic circular dichroism (ECD) calculation was used to identify the absolute structure of compound <b>1</b>. Among the isolated compounds, compound <b>1</b> displayed a potent anti-neuroinflammation with an IC<sub>50</sub> value of 9.87 ± 1.71 <i>μ</i>M.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-7"},"PeriodicalIF":1.3,"publicationDate":"2024-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141468142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-30DOI: 10.1080/10286020.2024.2372383
Xia Zhang, Fang-Xin Wang, Zi-Wei Li, Song Wang, Shi-Qing Zhang, Min Song, Xiao-Qi Zhang
Four new alkaloids, arecatines A-D (1-4), were isolated from the peels of Areca catechu. Compound 1 is an unusual piperidine-pyridine hybrid alkaloid, whereas compounds 2-4 feature bis-piperidine alkaloids. Their structures were elucidated by UV, IR, HRESIMS, and NMR spectra analysis. The molecular docking analysis indicated that compound 3 exhibited the best binding affinity with the GABAA receptor, indicating its potential anti-epilepsy activity.
{"title":"Bis-piperidine alkaloids from the peels of <i>Areca catechu</i>.","authors":"Xia Zhang, Fang-Xin Wang, Zi-Wei Li, Song Wang, Shi-Qing Zhang, Min Song, Xiao-Qi Zhang","doi":"10.1080/10286020.2024.2372383","DOIUrl":"https://doi.org/10.1080/10286020.2024.2372383","url":null,"abstract":"<p><p>Four new alkaloids, arecatines A-D (<b>1</b>-<b>4</b>), were isolated from the peels of <i>Areca catechu</i>. Compound <b>1</b> is an unusual piperidine-pyridine hybrid alkaloid, whereas compounds <b>2</b>-<b>4</b> feature bis-piperidine alkaloids. Their structures were elucidated by UV, IR, HRESIMS, and NMR spectra analysis. The molecular docking analysis indicated that compound <b>3</b> exhibited the best binding affinity with the GABA<sub>A</sub> receptor, indicating its potential anti-epilepsy activity.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-7"},"PeriodicalIF":1.3,"publicationDate":"2024-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141468143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-28DOI: 10.1080/10286020.2024.2360047
One new canthinone glycoside (1), together with six known compounds (2–7) including three lignans (2–4), two coumarins (5–6) and one phenol (7) was isolated from the root barks of Ailanthus altissima. The structure of new compound 1 was established by the interpretation of UV, IR, MS and NMR data, while its absolute configuration was determined by acid hydrolysis and GIAO NMR calculations with DP4+ probability analysis. The inhibitory effects of all compounds on Nitric oxide (NO) production were investigated in lipopolysaccharide (LPS)-induced RAW 264.7 cells. Results showed that compounds 2 and 5 displayed NO production inhibitory activity with IC50 values of 30.1 and 15.3 μM, respectively.
{"title":"A new canthinone glycoside isolated from the root barks of Ailanthus altissima with NO inhibitory activity","authors":"","doi":"10.1080/10286020.2024.2360047","DOIUrl":"10.1080/10286020.2024.2360047","url":null,"abstract":"<div><p>One new canthinone glycoside (<strong>1</strong>), together with six known compounds (<strong>2</strong>–<strong>7</strong>) including three lignans (<strong>2</strong>–<strong>4</strong>), two coumarins (<strong>5</strong>–<strong>6)</strong> and one phenol (<strong>7)</strong> was isolated from the root barks of <em>Ailanthus altissima</em>. The structure of new compound <strong>1</strong> was established by the interpretation of UV, IR, MS and NMR data, while its absolute configuration was determined by acid hydrolysis and GIAO NMR calculations with DP4+ probability analysis. The inhibitory effects of all compounds on Nitric oxide (NO) production were investigated in lipopolysaccharide (LPS)-induced RAW 264.7 cells. Results showed that compounds <strong>2</strong> and <strong>5</strong> displayed NO production inhibitory activity with IC<sub>50</sub> values of 30.1 and 15.3 <em>μ</em>M, respectively.</p></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"26 10","pages":"Pages 1247-1253"},"PeriodicalIF":1.3,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141468141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-26DOI: 10.1080/10286020.2024.2362383
Histone deacetylase 6 (HDAC6) was a potential target for Alzheimer’s disease (AD). In this study, a series of novel oxyevodiamine-based HDAC6 inhibitors with a variety of linker moieties were designed, synthesized and evaluated. Compound 12 with a benzyl linker was identified as a high potent and selective HDAC6 inhibitor. It inhibited HDAC6 with an IC50 value of 6.2 nM and was more than 200 fold selectivity over HDAC1. It also had lower cytotoxicity and higher anti-H2O2 activity in vitro comparing with other derivatives. Compound 12 might be a good lead as novel HDAC6 inhibitor for the treatment of AD.
{"title":"Design, synthesis and biological activity of oxyevodiamine-based histone deacetylase 6 inhibitors","authors":"","doi":"10.1080/10286020.2024.2362383","DOIUrl":"10.1080/10286020.2024.2362383","url":null,"abstract":"<div><div>Histone deacetylase 6 (HDAC6) was a potential target for Alzheimer’s disease (AD). In this study, a series of novel oxyevodiamine-based HDAC6 inhibitors with a variety of linker moieties were designed, synthesized and evaluated. Compound <strong>12</strong> with a benzyl linker was identified as a high potent and selective HDAC6 inhibitor. It inhibited HDAC6 with an IC<sub>50</sub> value of 6.2 nM and was more than 200 fold selectivity over HDAC1. It also had lower cytotoxicity and higher anti-H<sub>2</sub>O<sub>2</sub> activity <em>in vitro</em> comparing with other derivatives. Compound <strong>12</strong> might be a good lead as novel HDAC6 inhibitor for the treatment of AD.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"26 11","pages":"Pages 1328-1338"},"PeriodicalIF":1.3,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141468153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-26DOI: 10.1080/10286020.2024.2358831
The therapeutic potential of two important flavonoids, i.e. hesperidin and naringenin, remains unutilized due to pharmacokinetics issues, especially poor aqueous solubility. Hydrotropic solid dispersions with different agents like sodium salicylate, niacinamide, benzoic acid, and urea etc. can change the solubility profile of poorly soluble drugs. The current study investigated the potential of different hydrotropic agents in improving the solubility of both natural bioactives. The hydrotropic solid dispersion in 1:3 w/w drug: sodium salicylate ratio showed maximum solubility and dissolution amongst all the tested hydrotropes. This novel and economical approach could be explored for other poorly soluble pharmaceuticals.
{"title":"Enhancement of aqueous solubility of hesperidin and naringenin utilizing hydrotropic solubilization technique: characterization and in vitro evaluation","authors":"","doi":"10.1080/10286020.2024.2358831","DOIUrl":"10.1080/10286020.2024.2358831","url":null,"abstract":"<div><p>The therapeutic potential of two important flavonoids, i.e. hesperidin and naringenin, remains unutilized due to pharmacokinetics issues, especially poor aqueous solubility. Hydrotropic solid dispersions with different agents like sodium salicylate, niacinamide, benzoic acid, and urea etc. can change the solubility profile of poorly soluble drugs. The current study investigated the potential of different hydrotropic agents in improving the solubility of both natural bioactives. The hydrotropic solid dispersion in 1:3 w/w drug: sodium salicylate ratio showed maximum solubility and dissolution amongst all the tested hydrotropes. This novel and economical approach could be explored for other poorly soluble pharmaceuticals.</p></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"26 10","pages":"Pages 1207-1218"},"PeriodicalIF":1.3,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141468154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
扫码关注我们
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号