Antibiotic resistance demands new agents. We disclosed the first total synthesis of the natural xanthone V1 (1), which featured a regioselective Claisen cyclization and a Claisen/Cope rearrangement that installed the pyran ring and isopentenyl unit. The synthetic compound showed moderate antibacterial potency (MICs 16-64 μg/ml) across multiple strains and synergized with ciprofloxacin against MRSA. It exhibited low cytotoxicity toward mammalian cells and minimal hemolysis, thereby supporting xanthone V1 as a promising lead for anti-MRSA therapy.
{"title":"First total synthesis and antimicrobial evaluation of xanthone V1.","authors":"Fei Tan, Meng-Qi Wang, He-Fei Shi, Chun-Ran Zhang, De-Xiu Cui, Hong-Bo Dong","doi":"10.1080/10286020.2025.2581720","DOIUrl":"https://doi.org/10.1080/10286020.2025.2581720","url":null,"abstract":"<p><p>Antibiotic resistance demands new agents. We disclosed the first total synthesis of the natural xanthone V1 (<b>1</b>), which featured a regioselective Claisen cyclization and a Claisen/Cope rearrangement that installed the pyran ring and isopentenyl unit. The synthetic compound showed moderate antibacterial potency (MICs 16-64 μg/ml) across multiple strains and synergized with ciprofloxacin against MRSA. It exhibited low cytotoxicity toward mammalian cells and minimal hemolysis, thereby supporting xanthone V1 as a promising lead for anti-MRSA therapy.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-14"},"PeriodicalIF":1.3,"publicationDate":"2025-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145438025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-03DOI: 10.1080/10286020.2025.2577286
Le Thi-Kim-Dung, Nguyen Thi-Nhu-Quynh, Le Thanh-Nguyen, Tram Nguyen-Khanh-Trinh, Nguyen Thi-Phuong, Thi-Hoai-Thu Nguyen, Ngoc-Hong Nguyen, Jirapast Sichaem, Thuc-Huy Duong
A new verrucosane-type diterpenoid, bantamenside (1), along with six known compounds (2-7), was isolated from the Vietnamese liverwort Plagiochila bantamensis. The structure of the new compound was determined using comprehensive spectroscopic methods, including 1D and 2D NMR techniques as well as high-resolution mass spectrometry. Furthermore, all isolated compounds were evaluated for their ability to inhibit nitric oxide (NO) production. Compounds 1-3 and 6-7 demonstrated notable NO inhibitory activity, with IC50 values ranging from 12.85 to 51.37 µM, outperforming or comparable to that of the positive control L-NMMA (IC50 41.30 ± 6.60 µM).
{"title":"A new verrucosane diterpenoid from the Vietnamese liverwort <i>Plagiochila bantamensis</i>.","authors":"Le Thi-Kim-Dung, Nguyen Thi-Nhu-Quynh, Le Thanh-Nguyen, Tram Nguyen-Khanh-Trinh, Nguyen Thi-Phuong, Thi-Hoai-Thu Nguyen, Ngoc-Hong Nguyen, Jirapast Sichaem, Thuc-Huy Duong","doi":"10.1080/10286020.2025.2577286","DOIUrl":"https://doi.org/10.1080/10286020.2025.2577286","url":null,"abstract":"<p><p>A new verrucosane-type diterpenoid, bantamenside (<b>1</b>), along with six known compounds (<b>2-7</b>), was isolated from the Vietnamese liverwort <i>Plagiochila bantamensis</i>. The structure of the new compound was determined using comprehensive spectroscopic methods, including 1D and 2D NMR techniques as well as high-resolution mass spectrometry. Furthermore, all isolated compounds were evaluated for their ability to inhibit nitric oxide (NO) production. Compounds <b>1-3</b> and <b>6-7</b> demonstrated notable NO inhibitory activity, with IC<sub>50</sub> values ranging from 12.85 to 51.37 µM, outperforming or comparable to that of the positive control L-NMMA (IC<sub>50</sub> 41.30 ± 6.60 µM).</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-9"},"PeriodicalIF":1.3,"publicationDate":"2025-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145437977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-02DOI: 10.1080/10286020.2025.2481274
Yin-Xia Yang , Li-Hua Gong , Fu-Hua Peng , Jian-Guo Hu , Tao Jiang , Bin Li , Yue Yang , Jing-Ying Peng , Xue-Mei Gao
Phytochemical investigation of Calophyllum polyanthum led to the isolation of six xanthones, six chromanone derivatives, one coumarin, one glycoside and one flavonoid, including two new xanthones named caledonixanthone M (1), caledonixanthone N (2) and thirteen known compounds (3–15). Among them, the structures of 1 and 2 were elucidated by analysis of spectroscopic data. Some known compounds showed potent α-glucosidase inhibitory and cytotoxic activity. Especially, compound 14 showed moderate inhibitory activities on α-glucosidase with IC50 value of 79.41 ± 0.22 µM, and compound 5 displayed anticancer effect on A549 non-small cell lung cancer cells.
{"title":"Chemical constituents from Calophyllum polyanthum and their biological activity","authors":"Yin-Xia Yang , Li-Hua Gong , Fu-Hua Peng , Jian-Guo Hu , Tao Jiang , Bin Li , Yue Yang , Jing-Ying Peng , Xue-Mei Gao","doi":"10.1080/10286020.2025.2481274","DOIUrl":"10.1080/10286020.2025.2481274","url":null,"abstract":"<div><div>Phytochemical investigation of <em>Calophyllum polyanthum</em> led to the isolation of six xanthones, six chromanone derivatives, one coumarin, one glycoside and one flavonoid, including two new xanthones named caledonixanthone M (<strong>1</strong>), caledonixanthone N (<strong>2</strong>) and thirteen known compounds (<strong>3–15</strong>). Among them, the structures of <strong>1</strong> and <strong>2</strong> were elucidated by analysis of spectroscopic data. Some known compounds showed potent <em>α</em>-glucosidase inhibitory and cytotoxic activity. Especially, compound <strong>14</strong> showed moderate inhibitory activities on <em>α</em>-glucosidase with IC<sub>50</sub> value of 79.41 ± 0.22 µM, and compound <strong>5</strong> displayed anticancer effect on A549 non-small cell lung cancer cells.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 11","pages":"Pages 1650-1657"},"PeriodicalIF":1.3,"publicationDate":"2025-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-02DOI: 10.1080/10286020.2025.2527875
Yan Wang , Hui-Min Yan , Jin-Cai Lu , Shi-Shan Yu
Three new grayanane-type diterpenoids (1–3), together with eight known compounds, were isolated from the flowers of Rhododendron molle G. Don. The structures of new compounds were fully determined based on spectroscopic analysis, including HRESIMS, 1D, and 2D NMR data. The absolute configuration of the new compounds was confirmed by single-crystal X-ray diffraction. The analgesic activities of compounds 1–7 and 10–11 were evaluated by the acetic acid-induced writhing method in mice. Compounds 3 and 6 had significant analgesic effects at a low dose of 0.2 mg/kg, and the writhe inhibition rates were 66.3% and 82.9%, respectively. Compounds 3–4 and 10–11 also showed significant analgesic effects at a dose of 1 mg/kg (writhe inhibition rate was 66.8%–91.7%). Compounds 5, 7, and 10–11 showed significant analgesic effects at a dose of 5 mg/kg (writhe inhibition rate was 68.4%–83.4%).
{"title":"Three new antinociceptive diterpenoids from the flowers of Rhododendron molle","authors":"Yan Wang , Hui-Min Yan , Jin-Cai Lu , Shi-Shan Yu","doi":"10.1080/10286020.2025.2527875","DOIUrl":"10.1080/10286020.2025.2527875","url":null,"abstract":"<div><div>Three new grayanane-type diterpenoids (<strong>1–3</strong>), together with eight known compounds, were isolated from the flowers of <em>Rhododendron molle</em> G. Don. The structures of new compounds were fully determined based on spectroscopic analysis, including HRESIMS, 1D, and 2D NMR data. The absolute configuration of the new compounds was confirmed by single-crystal X-ray diffraction. The analgesic activities of compounds <strong>1–7</strong> and <strong>10–11</strong> were evaluated by the acetic acid-induced writhing method in mice. Compounds <strong>3</strong> and <strong>6</strong> had significant analgesic effects at a low dose of 0.2 mg/kg, and the writhe inhibition rates were 66.3% and 82.9%, respectively. Compounds <strong>3–4</strong> and <strong>10–11</strong> also showed significant analgesic effects at a dose of 1 mg/kg (writhe inhibition rate was 66.8%–91.7%). Compounds <strong>5</strong>, <strong>7,</strong> and <strong>10–11</strong> showed significant analgesic effects at a dose of 5 mg/kg (writhe inhibition rate was 68.4%–83.4%).</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 11","pages":"Pages 1619-1629"},"PeriodicalIF":1.3,"publicationDate":"2025-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144649580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-02DOI: 10.1080/10286020.2025.2521542
Ya-Nan Tian , Yu-Wei Niu , Ke-Liang Chen , Yang Liu , Chen-Yu Yang , Xing-Bao Jia , Yang Yang , Yun-Bao Liu
Three new shikimate-conjugated meroterpenes, tricycloalternarenes Z1–Z3 (1–3), were isolated from Alternaria alternate, an endophytic fungus residing in Apis mellifera. The structures of new compounds were characterized by analyses of their NMR and HRESIMS data. The absolute configurations were assigned through electronic circular dichroism (ECD) calculations and CD spectra. Bioassay results showed that tricycloalternarene Z1 (1) exhibited moderate anti-inflammatory activity against the LPS-induced production of NO in RAW 264.7 cells, with an IC50 value of 0.93 µM.
{"title":"Three new shikimate-conjugated meroterpenoids from Alternaria alternata isolated from an entomopathogenic fungus Apis mellifera","authors":"Ya-Nan Tian , Yu-Wei Niu , Ke-Liang Chen , Yang Liu , Chen-Yu Yang , Xing-Bao Jia , Yang Yang , Yun-Bao Liu","doi":"10.1080/10286020.2025.2521542","DOIUrl":"10.1080/10286020.2025.2521542","url":null,"abstract":"<div><div>Three new shikimate-conjugated meroterpenes, tricycloalternarenes Z1–Z3 (<strong>1</strong>–<strong>3</strong>), were isolated from <em>Alternaria alternate</em>, an endophytic fungus residing in <em>Apis mellifera</em>. The structures of new compounds were characterized by analyses of their NMR and HRESIMS data. The absolute configurations were assigned through electronic circular dichroism (ECD) calculations and CD spectra. Bioassay results showed that tricycloalternarene Z1 (<strong>1</strong>) exhibited moderate anti-inflammatory activity against the LPS-induced production of NO in RAW 264.7 cells, with an IC<sub>50</sub> value of 0.93 <em>µ</em>M.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 11","pages":"Pages 1641-1649"},"PeriodicalIF":1.3,"publicationDate":"2025-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144560239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-02DOI: 10.1080/10286020.2025.2481285
Fei Song , Jie Li , Bin-Bin Song , Zheng-Yi Shi , Zhang-Rong Hou , Ye-Ting Zhang , Yu-Lin Duan , Jian-Ping Wang , Chang-Xing Qi , Yong-Hui Zhang
The chemical study of Hypericum patulum provided a new degraded lupane-type triterpenoid, patutriter A (1), and seven known compounds (2–8). Their structures were identified by spectroscopic techniques and single crystal diffraction experiment. Structurally, patutriter A (1) was a new lupane with a 28-nor-skeleton. More importantly, compounds 3–5 exhibited moderate immunosuppressive effects that inhibit the anti-CD3/anti-CD28 monoclonal antibodies (mAbs) and concanavalin A (ConA) stimulated murine splenocytes proliferation, with IC50 values from (15.25 ± 1.78) μM to (22.58 ± 3.47) μM, disclosing that those compounds might serve as potential lead compounds in the development of new immunosuppressants.
{"title":"Discovery of immunosuppressive secondary metabolites from Hypericum patulum","authors":"Fei Song , Jie Li , Bin-Bin Song , Zheng-Yi Shi , Zhang-Rong Hou , Ye-Ting Zhang , Yu-Lin Duan , Jian-Ping Wang , Chang-Xing Qi , Yong-Hui Zhang","doi":"10.1080/10286020.2025.2481285","DOIUrl":"10.1080/10286020.2025.2481285","url":null,"abstract":"<div><div>The chemical study of <em>Hypericum patulum</em> provided a new degraded lupane-type triterpenoid, patutriter A (<strong>1</strong>), and seven known compounds (<strong>2</strong>–<strong>8</strong>). Their structures were identified by spectroscopic techniques and single crystal diffraction experiment. Structurally, patutriter A (<strong>1</strong>) was a new lupane with a 28-<em>nor</em>-skeleton. More importantly, compounds <strong>3</strong>–<strong>5</strong> exhibited moderate immunosuppressive effects that inhibit the anti-CD3/anti-CD28 monoclonal antibodies (mAbs) and concanavalin A (ConA) stimulated murine splenocytes proliferation, with IC<sub>50</sub> values from (15.25 ± 1.78) μM to (22.58 ± 3.47) μM, disclosing that those compounds might serve as potential lead compounds in the development of new immunosuppressants.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 11","pages":"Pages 1729-1735"},"PeriodicalIF":1.3,"publicationDate":"2025-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
With the rise in health and neurological concerns around the globe, nutraceuticals are surpassing the harms of drug treatment. Alpha-lipoic acid, an organosulfur naturally abundant biomolecule that has potent protective and therapeutic effects in psychiatric and neurological disorders. Studies targeting alpha-lipoic acid in the brain have concluded that it modulates oxidative stress, neuronal aging, apoptosis, mitochondrial dysfunction, neuro-inflammation, cellular signaling, neurotransmission, and receptor functioning. Various clinical studies have been conducted, yielding satisfactory results indicating alpha-lipoic acid as a therapeutic agent for neurodegenerative and psychiatric disorders. However, further studies are still required to use alpha-lipoic acid as a monotherapeutic agent and to design a dosage regimen. The article aims to demonstrate alpha-lipoic acid as a potent biomolecule for curing and preventing psychiatric and neural disorders.
{"title":"Expanding the role of alpha lipoic acid for psychiatric and neurological health","authors":"Ishu Garg , Harish Kumar , Raj Kumari , Anupama Singh , Ravi Maurya , Rashi Pandey , Shruti Bhatt","doi":"10.1080/10286020.2025.2509765","DOIUrl":"10.1080/10286020.2025.2509765","url":null,"abstract":"<div><div>With the rise in health and neurological concerns around the globe, nutraceuticals are surpassing the harms of drug treatment. Alpha-lipoic acid, an organosulfur naturally abundant biomolecule that has potent protective and therapeutic effects in psychiatric and neurological disorders. Studies targeting alpha-lipoic acid in the brain have concluded that it modulates oxidative stress, neuronal aging, apoptosis, mitochondrial dysfunction, neuro-inflammation, cellular signaling, neurotransmission, and receptor functioning. Various clinical studies have been conducted, yielding satisfactory results indicating alpha-lipoic acid as a therapeutic agent for neurodegenerative and psychiatric disorders. However, further studies are still required to use alpha-lipoic acid as a monotherapeutic agent and to design a dosage regimen. The article aims to demonstrate alpha-lipoic acid as a potent biomolecule for curing and preventing psychiatric and neural disorders.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 11","pages":"Pages 1557-1587"},"PeriodicalIF":1.3,"publicationDate":"2025-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144208612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-02DOI: 10.1080/10286020.2025.2568630
Wan-Qi Zhang , Xin-Yue Li , Ming-Hui Sun , Jie Zhou , Guo-Ru Shi , De-Quan Yu , Yan-Fei Liu
Three new compounds (1–3), including two cyclopentanoid monoterpenes rubicoside A (1) and rubicocin A (2), and one naphthohydroquinone glycoside rubinaphthin E (3), together with six known analogues (4–9), were isolated from the roots of Rubia cordifolia. The structures of compounds 1–3 were established by chemical methods and spectroscopic analysis. Compounds 1–9 were tested for their cytotoxicity and screened for stable transfection of recombinant dopamine receptors in HEK293 cell lines.
{"title":"Three new compounds from the roots of Rubia cordifolia","authors":"Wan-Qi Zhang , Xin-Yue Li , Ming-Hui Sun , Jie Zhou , Guo-Ru Shi , De-Quan Yu , Yan-Fei Liu","doi":"10.1080/10286020.2025.2568630","DOIUrl":"10.1080/10286020.2025.2568630","url":null,"abstract":"<div><div>Three new compounds (<strong>1</strong>–<strong>3)</strong>, including two cyclopentanoid monoterpenes rubicoside A (<strong>1</strong>) and rubicocin A (<strong>2</strong>), and one naphthohydroquinone glycoside rubinaphthin E (<strong>3</strong>), together with six known analogues (<strong>4</strong>–<strong>9)</strong>, were isolated from the roots of <em>Rubia cordifolia</em>. The structures of compounds <strong>1</strong>–<strong>3</strong> were established by chemical methods and spectroscopic analysis. Compounds <strong>1</strong>–<strong>9</strong> were tested for their cytotoxicity and screened for stable transfection of recombinant dopamine receptors in HEK293 cell lines.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 11","pages":"Pages 1599-1607"},"PeriodicalIF":1.3,"publicationDate":"2025-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145232641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In our study, the functional and biological properties of the developed probiotic formulations containing Lactobacillus plantarum and isatin (Couroupita guianensis) have been evaluated. The developed probiotic formulations have demonstrated remarkable antioxidant, antimicrobial, and cholesterol-lowering properties (67.3 ± 0.57%). In addition, they exhibit high survivability in simulated oral fluid (98.8%). Furthermore, extracellular enzyme production iterates other health attributes of probiotic formulations to the human system by improving the utilization of nutrients in the intestine. In sum, the developed probiotic formulations have unveiled probiotic functions and safer applications, which could pave the way to develop functional foods or lead compounds for drug discovery.
{"title":"Functional and biological characterization of Lactobacillus plantarum with isatin for use as probiotics for therapeutic options","authors":"Ramya Ravindhiran , Mahalakshmi Subramanian , Madhumitha Rajalingam , Madhumitha Gunasekaran , Karthiga Sivarajan , Kumarappan Chidambaram , Kavitha Dhandapani","doi":"10.1080/10286020.2025.2475469","DOIUrl":"10.1080/10286020.2025.2475469","url":null,"abstract":"<div><div>In our study, the functional and biological properties of the developed probiotic formulations containing <em>Lactobacillus plantarum</em> and isatin (<em>Couroupita guianensis</em>) have been evaluated. The developed probiotic formulations have demonstrated remarkable antioxidant, antimicrobial, and cholesterol-lowering properties (67.3 ± 0.57%). In addition, they exhibit high survivability in simulated oral fluid (98.8%). Furthermore, extracellular enzyme production iterates other health attributes of probiotic formulations to the human system by improving the utilization of nutrients in the intestine. In sum, the developed probiotic formulations have unveiled probiotic functions and safer applications, which could pave the way to develop functional foods or lead compounds for drug discovery.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 11","pages":"Pages 1673-1689"},"PeriodicalIF":1.3,"publicationDate":"2025-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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