Journal of Asian Natural Products Research最新文献

Multiple sclerosis (MS) is an autoimmune-mediated, heterogeneous, multifactorial central nervous system degenerative disease influenced by genetics and environment. Ferroptosis, an iron-dependent lipid peroxidation/reactive oxygen species-induced programmed cell death, exacerbates MS pathology. Glutathione peroxidase 4 (GPX4) regulates ferroptosis by clearing peroxides to sustain cells. Targeting GPX4-mediated ferroptosis, especially via safe, potent natural compounds, is a promising MS treatment. This review explores GPX4-dependent ferroptosis's role in MS progression and summarizes natural compounds for MS therapy.

Two new (1-2) and five known (3-7) dihydro-β-agarofuran derivatives were isolated from the roots of Tripterygium wilfordii. The structures of new compounds were elucidated by spectroscopic techniques, such as UV, IR, HRESIMS and NMR. And the structure of compound 1 was confirmed by X-ray crystallographic. Cytotoxic activity assays against four human tumor cell lines (SK-MEL-2, HCC1806, HUH-7, PANC-1) were assessed for compounds 1-7. Compound 2 exhibited pronounced cytotoxicity against SK-MEL-2 cells with an IC₅₀ value of 9.18 μM. Additionally, compound 5 showed significant cytotoxic effects on SK-MEL-2 and HCC1806 cells with IC₅₀ values of 4.59 μM and 8.14 μM, respectively.

Four new compounds (1-4), along with 22 known metabolites (5-26), were isolated from the fungus Biscogniauxia sp. 8703. The structures of the new compounds were elucidated based on NMR, MS, and ECD analysis. Compounds 1 and 2 were identified as heliannuol D analogs, which exhibited anti-inflammatory activity by inhibiting NO production in LPS-induced RAW 264.7 cell, with IC₅₀ values of 7.14 and 25.25 μM, respectively.

Two novel polyacetylenic compounds were successfully separated from the dichloromethane extract of the aerial parts of Bidens parviflora Willd., known for its ethnomedicinal use in traditional Dai medicine. These compounds were structurally elucidated and identified as (2R)-trideca-3E,5Z,11E-triene-7,9-diyne-1,2,13-triol (1), and (2R)-trideca-11E-ene-5,7,9-triyne-1,2,13-triol (2). Their chemical structures were confirmed through a comprehensive analysis involving ultraviolet (UV) spectroscopy, infrared (IR) spectroscopy, high-resolution electrospray ionization mass spectrometry (HR-ESI-MS), as well as detailed one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance (NMR) spectroscopic data, and measurements of specific optical rotation.

A newly discovered chloroisosulochrin derivative, involving demethychloroisosul (1), and a novel chromone metabolite, reduchromone (2), were extracted from Penicilium sp., an endophytic fungus residing in Rhododendron molle. The structures of these compounds were elucidated through a comprehensive analysis of their 1D and 2D NMR and HRESIMS data. In addition, the X-ray diffraction analysis of demethychloroisosul (1) is the first example to confirm the structure of chloroisosulochrin by single-crystal data. Notably, demethychloroisosul (1) exhibited moderate cytotoxic efficacy against HepG2 liver cancer cells, with a half-maximal inhibitory concentration value of 30.18 μM.

Antibiotic resistance demands new agents. We disclosed the first total synthesis of the natural xanthone V1 (1), which featured a regioselective Claisen cyclization and a Claisen/Cope rearrangement that installed the pyran ring and isopentenyl unit. The synthetic compound showed moderate antibacterial potency (MICs 16-64 μg/ml) across multiple strains and synergized with ciprofloxacin against MRSA. It exhibited low cytotoxicity toward mammalian cells and minimal hemolysis, thereby supporting xanthone V1 as a promising lead for anti-MRSA therapy.

A new verrucosane-type diterpenoid, bantamenside (1), along with six known compounds (2-7), was isolated from the Vietnamese liverwort Plagiochila bantamensis. The structure of the new compound was determined using comprehensive spectroscopic methods, including 1D and 2D NMR techniques as well as high-resolution mass spectrometry. Furthermore, all isolated compounds were evaluated for their ability to inhibit nitric oxide (NO) production. Compounds 1-3 and 6-7 demonstrated notable NO inhibitory activity, with IC₅₀ values ranging from 12.85 to 51.37 µM, outperforming or comparable to that of the positive control L-NMMA (IC₅₀ 41.30 ± 6.60 µM).