Pub Date : 2024-09-24DOI: 10.1080/10286020.2024.2405224
Pan-Pan Wang , Yan-Dan Liu , Lan-Tian Cui , Gao Li , Long-Xuan Zhao , Mei Jin
As a kind of glycoside, pentacyclic triterpenoid saponins have good biological activities, such as anticancer, antibacterial, antiviral and hypoglycemic effects [1]. In this paper, twenty-four pentacyclic triterpenoid derivatives, including twelve monosaccharide derivatives, were designed and synthesized. The anticancer effect and antibacterial activities of all compounds were evaluated. It is noteworthy that compound UA-2b has the strongest inhibitory effect on the growth of A549, Hela and HepG2 cancer cells (IC50 = 5.37 ± 0.22 µM, 5.82 ± 0.25 µM and 5.47 ± 0.06 µM, respectively). Compounds OA-2b, OA-6a, OA-6b, UA-2b and UA-6a have the best activity against Escherichia coli 1924 (MIC = 16 μg/ml).
{"title":"Synthesis, characterization and anticancer, antibacterial activities of pentacyclic triterpenoid glycoside derivatives","authors":"Pan-Pan Wang , Yan-Dan Liu , Lan-Tian Cui , Gao Li , Long-Xuan Zhao , Mei Jin","doi":"10.1080/10286020.2024.2405224","DOIUrl":"10.1080/10286020.2024.2405224","url":null,"abstract":"<div><div>As a kind of glycoside, pentacyclic triterpenoid saponins have good biological activities, such as anticancer, antibacterial, antiviral and hypoglycemic effects [<span><span>1</span></span>]. In this paper, twenty-four pentacyclic triterpenoid derivatives, including twelve monosaccharide derivatives, were designed and synthesized. The anticancer effect and antibacterial activities of all compounds were evaluated. It is noteworthy that compound <strong>UA-2b</strong> has the strongest inhibitory effect on the growth of A549, Hela and HepG2 cancer cells (IC<sub>50</sub> = 5.37 ± 0.22 µM, 5.82 ± 0.25 µM and 5.47 ± 0.06 µM, respectively). Compounds <strong>OA-2b</strong>, <strong>OA-6a</strong>, <strong>OA-6b</strong>, <strong>UA-2b</strong> and <strong>UA-6a</strong> have the best activity against <em>Escherichia coli</em> 1924 (MIC = 16 μg/ml).</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 3","pages":"Pages 323-339"},"PeriodicalIF":1.3,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142347315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-23DOI: 10.1080/10286020.2024.2403617
Ji-Qiao Yuan, Xu-Yu Li, Yan-Nan Fan, Nan Fang, Ping Li, Xin-Zhu Wen, Qi Hou, Zi-Qian Zhang, Ming-Bao Lin
Rosmarinic acid (RosA), a hydrophilic phenolic compound found in various plants, has several biological effects such as anti-inflammatory and anti-apoptosis activities. However, its potential impact on chronic obstructive pulmonary disease (COPD) and its underlying mechanism has not been investigated. In this study, we explored the potential therapeutic effects and mechanism of RosA on COPD airway inflammation and alveolar epithelial apoptosis in vivo and in vitro. Our data suggested that RosA may be a therapeutic candidate for COPD with low toxicity. The corresponding mechanism lies in its anti-inflammatory effect on macrophage and bronchial epithelial cells, as well as protective effect on lung epithelial apoptosis via the jointly cross-target spleen tyrosine kinase (Syk).
迷迭香酸（RosA）是一种存在于多种植物中的亲水性酚类化合物，具有多种生物效应，如抗炎和抗细胞凋亡活性。然而，它对慢性阻塞性肺病（COPD）的潜在影响及其内在机制尚未得到研究。在这项研究中，我们探讨了 RosA 在体内和体外对慢性阻塞性肺病气道炎症和肺泡上皮细胞凋亡的潜在治疗作用及其机制。我们的数据表明，RosA 可能是慢性阻塞性肺病的一种低毒性候选治疗药物。其相应的机制在于它对巨噬细胞和支气管上皮细胞的抗炎作用，以及通过共同的交叉靶标脾酪氨酸激酶（Syk）对肺上皮细胞凋亡的保护作用。
{"title":"Rosmarinic acid suppresses the progression of COPD <i>via</i> Syk by modulating airway inflammation and epithelial apoptosis <i>in vivo</i> and <i>in vitro</i>.","authors":"Ji-Qiao Yuan, Xu-Yu Li, Yan-Nan Fan, Nan Fang, Ping Li, Xin-Zhu Wen, Qi Hou, Zi-Qian Zhang, Ming-Bao Lin","doi":"10.1080/10286020.2024.2403617","DOIUrl":"https://doi.org/10.1080/10286020.2024.2403617","url":null,"abstract":"<p><p>Rosmarinic acid (RosA), a hydrophilic phenolic compound found in various plants, has several biological effects such as anti-inflammatory and anti-apoptosis activities. However, its potential impact on chronic obstructive pulmonary disease (COPD) and its underlying mechanism has not been investigated. In this study, we explored the potential therapeutic effects and mechanism of RosA on COPD airway inflammation and alveolar epithelial apoptosis <i>in vivo</i> and <i>in vitro</i>. Our data suggested that RosA may be a therapeutic candidate for COPD with low toxicity. The corresponding mechanism lies in its anti-inflammatory effect on macrophage and bronchial epithelial cells, as well as protective effect on lung epithelial apoptosis via the jointly cross-target spleen tyrosine kinase (Syk).</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-15"},"PeriodicalIF":1.3,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142307841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-18DOI: 10.1080/10286020.2024.2402369
Ya-Kun Zhang , Jian-Bo Tong , Jing Tan , Min Yang , Xiao-Yu Xing , Yan-Rong Zeng , Zhan Xue , Cheng-Jian Tan
To elucidate the structure-activity relationship of 17 matrine alkaloids from Oxytropis ochrocephala Bunge, their effect on hepatitis B surface antigen (HBsAg) secretion was studied using the MTT assay. A 3D-QSAR analysis showed a strong correlation between chemical structures and biological activities (q2 = 0.625, r2 = 0.859). Molecular docking and molecular dynamics simulations revealed that hydrogen bonding and hydrophobic interactions with hepatitis B core protein (PDB:5T2P) are key to inhibiting HBsAg secretion, suggesting potential for developing natural anti-hepatitis B drugs.
{"title":"Study on the anti-HBV activity of matrine alkaloids from Oxytropis ochrocephala by MTT, 3d-QSAR, molecular docking and molecular dynamics simulation","authors":"Ya-Kun Zhang , Jian-Bo Tong , Jing Tan , Min Yang , Xiao-Yu Xing , Yan-Rong Zeng , Zhan Xue , Cheng-Jian Tan","doi":"10.1080/10286020.2024.2402369","DOIUrl":"10.1080/10286020.2024.2402369","url":null,"abstract":"<div><div>To elucidate the structure-activity relationship of 17 matrine alkaloids from <em>Oxytropis ochrocephala</em> Bunge, their effect on hepatitis B surface antigen (HBsAg) secretion was studied using the MTT assay. A 3D-QSAR analysis showed a strong correlation between chemical structures and biological activities (<em>q<sup>2</sup></em> = 0.625, <em>r<sup>2</sup></em> = 0.859). Molecular docking and molecular dynamics simulations revealed that hydrogen bonding and hydrophobic interactions with hepatitis B core protein (PDB:5T2P) are key to inhibiting HBsAg secretion, suggesting potential for developing natural anti-hepatitis B drugs.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 3","pages":"Pages 442-459"},"PeriodicalIF":1.3,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142253243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This study aimed to investigate the effects of wild Cordyceps sinensis on chronic obstructive pulmonary disease (COPD) rats through metabolomics approach, combined with biochemical parameters evaluations. Consequently, C. sinensis exhibited regulatory effects on the lung’s metabolic profiles in COPD rats. Treatment with C. sinensis potentially modulated glycerophospholipid metabolism, glutathione metabolism, and tryptophan metabolism, thereby alleviating oxidative stress (by decreasing MDA and GSSG, while increasing SOD and GSH) and inflammatory response (by inhibiting TNF-α, IL-8, and MMP-9) in COPD rats while improving lung tissue damage.
{"title":"Therapeutic potential of Cordyceps sinensis targeting oxidative stress and inflammatory response in the treatment of COPD rats: insights from metabolomics analysis","authors":"Ying-Ying Liu , Gai-Jie Dou , Yuan-Can Xiao , Xiao-Yi Chen , Li-Xin Wei , Wen-Bin Zhou","doi":"10.1080/10286020.2024.2403611","DOIUrl":"10.1080/10286020.2024.2403611","url":null,"abstract":"<div><div>This study aimed to investigate the effects of wild <em>Cordyceps sinensis</em> on chronic obstructive pulmonary disease (COPD) rats through metabolomics approach, combined with biochemical parameters evaluations. Consequently, <em>C. sinensis</em> exhibited regulatory effects on the lung’s metabolic profiles in COPD rats. Treatment with <em>C. sinensis</em> potentially modulated glycerophospholipid metabolism, glutathione metabolism, and tryptophan metabolism, thereby alleviating oxidative stress (by decreasing MDA and GSSG, while increasing SOD and GSH) and inflammatory response (by inhibiting TNF-α, IL-8, and MMP-9) in COPD rats while improving lung tissue damage.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 3","pages":"Pages 460-477"},"PeriodicalIF":1.3,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142253281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-17DOI: 10.1080/10286020.2024.2403612
Jamil Zargan , Ehsan Jahangirian , Haider A. Khan , Shakir Ali
The venom of the Odontobuthus doriae scorpion, prevalent in East Asia and Iran, has not been fully characterized. This study provides the first proteomic profile of O. doriae venom to explore its potential as a medical. 2D-PAGE analysis revealed 96 protein spots with isoelectric points from 3 to 9 and molecular weights between 6.6 to 205 kDa. Fourteen toxin fractions were isolated via HPLC, and SDS-PAGE showed seven protein bands ranging from 3.8 to 182 kDa. MALDI-TOF MS identified Peptide 1 and Peptide 2, resembling Hemoglobin beta-2 chain and Chaperonin HSP60 and suggest potential therapeutic applications for P1 and P2.
{"title":"Proteomic analysis of two novel peptides from the Odontobuthus doriae scorpion venom","authors":"Jamil Zargan , Ehsan Jahangirian , Haider A. Khan , Shakir Ali","doi":"10.1080/10286020.2024.2403612","DOIUrl":"10.1080/10286020.2024.2403612","url":null,"abstract":"<div><div>The venom of the <em>Odontobuthus doriae</em> scorpion, prevalent in East Asia and Iran, has not been fully characterized. This study provides the first proteomic profile of <em>O. doriae</em> venom to explore its potential as a medical. 2D-PAGE analysis revealed 96 protein spots with isoelectric points from 3 to 9 and molecular weights between 6.6 to 205 kDa. Fourteen toxin fractions were isolated via HPLC, and SDS-PAGE showed seven protein bands ranging from 3.8 to 182 kDa. MALDI-TOF MS identified Peptide 1 and Peptide 2, resembling Hemoglobin beta-2 chain and Chaperonin HSP60 and suggest potential therapeutic applications for P1 and P2.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 3","pages":"Pages 301-322"},"PeriodicalIF":1.3,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142253279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-09-14DOI: 10.1080/10286020.2024.2399572
Wen-Feng Chen , Meng-Meng Wang , Jing Tian , Bo-Heng Hu , Ya-Nan Lu , Chun-Mei Yang , Han-Qiao Liang , Rui-Zhang Feng
A new sterol, aspersterol E (1), a newly discovered alkaloid, asperginine A (2), and five known compounds (3–7) were obtained from the endophytic fungus Aspergillus sp. S3 of Hibiscus tiliaceus Linn. The compounds were extracted from their fermentation products using silica gel, ODS C18, and semi-preparative HPLC. The structure of each compound was determined through spectroscopic analysis. All the obtained compounds (1–7) were evaluated for their cytotoxic activity against the mouse pre-gastric cancer cell line MFC by using the MTT assay. The IC50 values of compounds 1, 2, 3, and 5 were found to be 153.43 μM, 61.25 μM, 73.19 μM, and 181.69 μM respectively.
从木槿内生真菌 Aspergillus sp. S3 中获得了一种新的甾醇--天冬甾醇 E (1)、一种新发现的生物碱--天冬精氨酸 A (2)和五种已知化合物 (3-7)。
{"title":"Chemical constituents from the endophytic fungus Aspergillus sp. S3 of Hibiscus tiliaceus","authors":"Wen-Feng Chen , Meng-Meng Wang , Jing Tian , Bo-Heng Hu , Ya-Nan Lu , Chun-Mei Yang , Han-Qiao Liang , Rui-Zhang Feng","doi":"10.1080/10286020.2024.2399572","DOIUrl":"10.1080/10286020.2024.2399572","url":null,"abstract":"<div><div>A new sterol, aspersterol E (<strong>1</strong>), a newly discovered alkaloid, asperginine A (<strong>2</strong>), and five known compounds (<strong>3–7</strong>) were obtained from the endophytic fungus <em>Aspergillus</em> sp. S3 of <em>Hibiscus tiliaceus</em> Linn. The compounds were extracted from their fermentation products using silica gel, ODS C18, and semi-preparative HPLC. The structure of each compound was determined through spectroscopic analysis. All the obtained compounds (<strong>1–7</strong>) were evaluated for their cytotoxic activity against the mouse pre-gastric cancer cell line MFC by using the MTT assay. The IC<sub>50</sub> values of compounds <strong>1</strong>, <strong>2</strong>, <strong>3,</strong> and <strong>5</strong> were found to be 153.43 μM, 61.25 μM, 73.19 μM, and 181.69 μM respectively.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 3","pages":"Pages 292-300"},"PeriodicalIF":1.3,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142253277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-30DOI: 10.1080/10286020.2024.2395566
Ming-Yang Chen , Meng Li , Qing-Yi Xu , Shu-Wang Zhang , Guang-Xi Ren , Chun-Sheng Liu
Acute promyelocytic leukemia (APL) is marked by a block at the promyelocyte stage. Treatments like ATRA and ATO face resistance and relapse issues. Plastrum testudinis, a traditional Chinese medicine, may offer therapeutic potential. This study investigated xtr-miR-22-3p from P. testudinis for treating APL. High expression of xtr-miR-22-3p was confirmed, with target prediction indicating interactions with key genes, including PML. xtr-miR-22-3p reduced HL-60 leukemia cell growth, altered the cell cycle, and selectively inhibited HL-60 proliferation while promoting BMSC growth, suggesting its potential as a targeted APL therapy.
{"title":"Therapeutic potential of xtr-miR-22-3p from Plastrum testudinis in acute promyelocytic leukemia","authors":"Ming-Yang Chen , Meng Li , Qing-Yi Xu , Shu-Wang Zhang , Guang-Xi Ren , Chun-Sheng Liu","doi":"10.1080/10286020.2024.2395566","DOIUrl":"10.1080/10286020.2024.2395566","url":null,"abstract":"<div><div>Acute promyelocytic leukemia (APL) is marked by a block at the promyelocyte stage. Treatments like ATRA and ATO face resistance and relapse issues. <em>Plastrum testudinis</em>, a traditional Chinese medicine, may offer therapeutic potential. This study investigated xtr-miR-22-3p from <em>P. testudinis</em> for treating APL. High expression of xtr-miR-22-3p was confirmed, with target prediction indicating interactions with key genes, including PML. xtr-miR-22-3p reduced HL-60 leukemia cell growth, altered the cell cycle, and selectively inhibited HL-60 proliferation while promoting BMSC growth, suggesting its potential as a targeted APL therapy.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 3","pages":"Pages 387-399"},"PeriodicalIF":1.3,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142195443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-17DOI: 10.1080/10286020.2024.2391472
Ze-Ye Tan , Gui Zhou , Yi-Ming Feng , Nan Xiang , Shan-Ni Li , Rui-Fang Xie , Xin Zhou
Polygoni Multiflori Caulis (PMC) is commonly used in clinical practice. While the adverse reactions of Polygoni Multiflori Radix (RPM) are well-known, the potential adverse reactions of PMC are often neglected. This article aims to clarify the relationship between hepatotoxic components in PMC and its various producing areas. This study provides a qualitative and quantitative analysis of PMC from various regions, which can serve as a basis for safe usage.
{"title":"Correlation analysis between potential hepatotoxicity and ingredient content of polygoni multiflori caulis","authors":"Ze-Ye Tan , Gui Zhou , Yi-Ming Feng , Nan Xiang , Shan-Ni Li , Rui-Fang Xie , Xin Zhou","doi":"10.1080/10286020.2024.2391472","DOIUrl":"10.1080/10286020.2024.2391472","url":null,"abstract":"<div><div><em>Polygoni Multiflori Caulis</em> (PMC) is commonly used in clinical practice. While the adverse reactions of <em>Polygoni Multiflori Radix</em> (RPM) are well-known, the potential adverse reactions of PMC are often neglected. This article aims to clarify the relationship between hepatotoxic components in PMC and its various producing areas. This study provides a qualitative and quantitative analysis of PMC from various regions, which can serve as a basis for safe usage.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 3","pages":"Pages 340-353"},"PeriodicalIF":1.3,"publicationDate":"2024-08-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142004303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-16DOI: 10.1080/10286020.2024.2390496
Shi-Jie Bi , An-Lei Yuan , Zi-Jun Chen , Yue Ren , Kai-Yang Liu , Chao-Qun Liu , Zhen-Zhen Xu , Ze-Wen Wang , Yan-Ling Zhang
Polygonati rhizoma (Huangjing in Chinese) is a common clinical tonic with the traditional effects of tonifying Qi, nourishing Yin. However, the lack of precise control of processing parameters has led to the uneven quality of processed Huangjing. A prediction model using the CRITIC method optimizes processing by correlating method, component contents, and biological activity, ensuring consistent quality and efficacy.
{"title":"Quantitative predictive model for screening optimal processing methods of Polygonati rhizoma","authors":"Shi-Jie Bi , An-Lei Yuan , Zi-Jun Chen , Yue Ren , Kai-Yang Liu , Chao-Qun Liu , Zhen-Zhen Xu , Ze-Wen Wang , Yan-Ling Zhang","doi":"10.1080/10286020.2024.2390496","DOIUrl":"10.1080/10286020.2024.2390496","url":null,"abstract":"<div><div><em>Polygonati</em> rhizoma (Huangjing in Chinese) is a common clinical tonic with the traditional effects of tonifying Qi, nourishing Yin. However, the lack of precise control of processing parameters has led to the uneven quality of processed Huangjing. A prediction model using the CRITIC method optimizes processing by correlating method, component contents, and biological activity, ensuring consistent quality and efficacy.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 3","pages":"Pages 368-386"},"PeriodicalIF":1.3,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141988067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-08-14DOI: 10.1080/10286020.2024.2365437
Three new prenylated C6–C3 compounds (1–3), together with two known prenylated C6–C3 compounds (4–5) and one known C6–C3 derivative (6), were isolated from the roots of Illicium brevistylum A. C. Smith. The structures of 1–3 were elucidated by spectroscopic methods including 1D and 2D NMR, HRESIMS, CD experiments and ECD calculations. The structure of illibrefunone A (1) was confirmed by single-crystal X-ray diffraction analysis. All compounds were evaluated in terms of their anti-inflammatory potential on nitric oxide (NO) generation in lipopolysaccharide-stimulated murine RAW264.7 macrophages and murine BV2 microglial cells, antiviral activity against Coxsackievirus B3 (CVB3) and influenza virus A/Hanfang/359/95 (H3N2). Compounds 3 and 4 exhibited potent inhibitory effects on the production of NO in RAW 264.7 cells with IC50 values of 20.57 and 12.87 μM respectively, which were greater than those of dexamethasone (positive control). Compounds 1 and 4–6 exhibited weak activity against Coxsackievirus B3, with IC50 values ranging from 25.87 to 33.33 μM.
从 Illicium brevistylum A. C. Smith 的根中分离出了三种新的前烯化 C6-C3 化合物（1-3），以及两种已知的前烯化 C6-C3 化合物（4-5）和一种已知的 C6-C3 衍生物（6）。通过光谱方法，包括一维和二维核磁共振、HRESIMS、CD 实验和 ECD 计算，阐明了 1-3 的结构。通过单晶 X 射线衍射分析证实了伊利布酮 A (1) 的结构。评估了所有化合物在脂多糖刺激的小鼠 RAW264.7 巨噬细胞和小鼠 BV2 微神经胶质细胞中产生一氧化氮（NO）的抗炎潜力，以及对柯萨奇病毒 B3（CVB3）和流感病毒 A/HANfang/359/95 （H3N2）的抗病毒活性。化合物 3 和 4 对 RAW 264.7 细胞中 NO 的产生具有强效抑制作用，IC50 值分别为 20.57 和 12.87 μM，高于地塞米松（阳性对照）。化合物 1 和 4-6 对柯萨奇病毒 B3 的活性较弱，IC50 值在 25.87 至 33.33 μM 之间。
{"title":"Bioactive prenylated c6–c3 derivatives from the roots of Illicium brevistylum","authors":"","doi":"10.1080/10286020.2024.2365437","DOIUrl":"10.1080/10286020.2024.2365437","url":null,"abstract":"<div><div>Three new prenylated C<sub>6</sub>–C<sub>3</sub> compounds (<strong>1–3</strong>), together with two known prenylated C<sub>6</sub>–C<sub>3</sub> compounds (<strong>4–5</strong>) and one known C<sub>6</sub>–C<sub>3</sub> derivative (<strong>6</strong>), were isolated from the roots of <em>Illicium brevistylum</em> A. C. Smith. The structures of <strong>1–3</strong> were elucidated by spectroscopic methods including 1D and 2D NMR, HRESIMS, CD experiments and ECD calculations. The structure of illibrefunone A (<strong>1</strong>) was confirmed by single-crystal X-ray diffraction analysis. All compounds were evaluated in terms of their anti-inflammatory potential on nitric oxide (NO) generation in lipopolysaccharide-stimulated murine RAW264.7 macrophages and murine BV2 microglial cells, antiviral activity against Coxsackievirus B3 (CVB3) and influenza virus A/Hanfang/359/95 (H3N2). Compounds <strong>3</strong> and <strong>4</strong> exhibited potent inhibitory effects on the production of NO in RAW 264.7 cells with IC<sub>50</sub> values of 20.57 and 12.87 μM respectively, which were greater than those of dexamethasone (positive control). Compounds <strong>1</strong> and <strong>4–6</strong> exhibited weak activity against Coxsackievirus B3, with IC<sub>50</sub> values ranging from 25.87 to 33.33 μM.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"26 11","pages":"Pages 1292-1304"},"PeriodicalIF":1.3,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141419215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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