Pub Date : 2024-07-03DOI: 10.1080/10286020.2024.2371032
Cai-Wen Fan, Li Luo, Mei-Shan Li, Yun-Qiong Gu, Yi-Lin Fang, Feng Qin, Heng-Shan Wang
Sesquilignans PD is a natural phenylpropanoid compound that was isolated from Zanthoxylum nitidum var. tomentosum. In this study, we assessed the antitumor effect of PD on SK-Hep-1 and HepG2 cells and the underlying molecular mechanisms. The results revealed that PD markedly inhibited the proliferation and migration of both liver cancer cells. Moreover, PD induced apoptosis, autophagy, and reactive oxygen species (ROS) production in liver cancer cells. Notably, PD increased the protein levels of p-p38 MAPK and p-ERK1/2 in liver cancer cells. This is the first report on the anticancer effect of PD, which is mediated via increased ROS production and MAPK signaling activation.
{"title":"Sesquilignans PD from <i>Zanthoxylum nitidum</i> var. <i>tomentosum</i> exerts antitumor effects <i>via</i> the ROS/MAPK pathway in liver cancer cells.","authors":"Cai-Wen Fan, Li Luo, Mei-Shan Li, Yun-Qiong Gu, Yi-Lin Fang, Feng Qin, Heng-Shan Wang","doi":"10.1080/10286020.2024.2371032","DOIUrl":"https://doi.org/10.1080/10286020.2024.2371032","url":null,"abstract":"<p><p>Sesquilignans <b>PD</b> is a natural phenylpropanoid compound that was isolated from <i>Zanthoxylum nitidum</i> var. <i>tomentosum</i>. In this study, we assessed the antitumor effect of <b>PD</b> on SK-Hep-1 and HepG2 cells and the underlying molecular mechanisms. The results revealed that <b>PD</b> markedly inhibited the proliferation and migration of both liver cancer cells. Moreover, <b>PD</b> induced apoptosis, autophagy, and reactive oxygen species (ROS) production in liver cancer cells. Notably, <b>PD</b> increased the protein levels of p-p38 MAPK and p-ERK1/2 in liver cancer cells. This is the first report on the anticancer effect of <b>PD</b>, which is mediated <i>via</i> increased ROS production and MAPK signaling activation.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141492125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fuzheng Huayu recipe (FZHYR) is a Chinese patent medicine for the treatment of fibrosis. The effects of FZHYR on pulmonary fibrosis and macrophage polarization were investigated in vitro. FZHYR inhibited pulmonary inflammation and fibrosis and M2 polarization of macrophages in bleomycin-induced pulmonary fibrosis (BPF) of rat model. Differentially expressed genes were screened by high-throughput mRNA sequencing and GSEA showed that oxidative phosphorylation (OXPHOS) was correlated with BPF. FZHYR inhibited expressions of Ndufa2 and Ndufa6 in lung tissues of BPF rats. These findings suggest that OXPHOS pathway serves as a possible target for pulmonary fibrosis therapy by FZHYR.
{"title":"Fuzheng Huayu recipe inhibits bleomycin-induced pulmonary fibrosis in rats by inhibiting M2 polarization of macrophages via the oxidative phosphorylation pathway.","authors":"Xing-Hua Yuan, Su-Fang Zhang, Yu Hang, Yan-Hua Shen, Shan-Fang Zhang, Wei-Ling Huang, Jing-Yi Huang, Ye-Chang Qian, Xiu-Lian Zhang, Qiu-Hong Li, Li Li","doi":"10.1080/10286020.2024.2371050","DOIUrl":"10.1080/10286020.2024.2371050","url":null,"abstract":"<p><p>Fuzheng Huayu recipe (FZHYR) is a Chinese patent medicine for the treatment of fibrosis. The effects of FZHYR on pulmonary fibrosis and macrophage polarization were investigated <i>in vitro</i>. FZHYR inhibited pulmonary inflammation and fibrosis and M2 polarization of macrophages in bleomycin-induced pulmonary fibrosis (BPF) of rat model. Differentially expressed genes were screened by high-throughput mRNA sequencing and GSEA showed that oxidative phosphorylation (OXPHOS) was correlated with BPF. FZHYR inhibited expressions of <i>Ndufa2</i> and <i>Ndufa6</i> in lung tissues of BPF rats. These findings suggest that OXPHOS pathway serves as a possible target for pulmonary fibrosis therapy by FZHYR.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141492123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-03DOI: 10.1080/10286020.2024.2370409
Han Qiu, Sheng-Nan Zhao, Jin-Ling Han, Miao Yu, Ruo-Di Wang, Jing-Ru Fang, Yan-Zhu Luo, Ling-Juan Zhu, Xin-Sheng Yao
The SwissTargetPrediction was employed to predict the potential drug targets of the active component of Si-Miao-Yong-An decoction (SMYAD). The therapeutic targets for HF were searched in the Genecard database, and Cytoscape3.9.1 software was used to construct the "drug-component-target-disease network" diagram. In addition, the String platform was used to construct Protein-Protein Interaction (PPI) network, and the DAVID database was used for GO and KEGG analysis. AutoDockTools-1.5.6 software was used for molecular docking verification. Network pharmacology studies have shown that AKT 1, ALB, and CASP 3 are the key targets of action of SMYAD against heart failure. The active compounds are quercetin and kaempferol.
{"title":"Exploring the mechanism of Si-Miao-Yong-An decoction on heart failure based on molecular docking and network pharmacology.","authors":"Han Qiu, Sheng-Nan Zhao, Jin-Ling Han, Miao Yu, Ruo-Di Wang, Jing-Ru Fang, Yan-Zhu Luo, Ling-Juan Zhu, Xin-Sheng Yao","doi":"10.1080/10286020.2024.2370409","DOIUrl":"https://doi.org/10.1080/10286020.2024.2370409","url":null,"abstract":"<p><p>The SwissTargetPrediction was employed to predict the potential drug targets of the active component of Si-Miao-Yong-An decoction (SMYAD). The therapeutic targets for HF were searched in the Genecard database, and Cytoscape3.9.1 software was used to construct the \"drug-component-target-disease network\" diagram. In addition, the String platform was used to construct Protein-Protein Interaction (PPI) network, and the DAVID database was used for GO and KEGG analysis. AutoDockTools-1.5.6 software was used for molecular docking verification. Network pharmacology studies have shown that AKT 1, ALB, and CASP 3 are the key targets of action of SMYAD against heart failure. The active compounds are quercetin and kaempferol.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141492122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-03DOI: 10.1080/10286020.2024.2368841
Jing-Rong Li, Ling-Yu Li, Hai-Xin Zhang, Ming-Qin Zhong, Zhong-Mei Zou
Breast cancer is the most common malignant tumor and a major cause of mortality among women worldwide. Atramacronoid A (AM-A) is a unique natural sesquiterpene lactone isolated from the rhizome of Atractylodes macrocephala Koidz (known as Baizhu in Chinese). Our study demonstrated that AM-A triggers a specific form of cell death resembling PANoptosis-like cell death. Further analysis indicated that AM-A-induced PANoptosis-like cell death is associated with the CASP-3/PARP-GSDMD-MLKL pathways, which are mediated by mitochondrial dysfunction. These results suggest the potential of AM-A as a lead compound and offer insights for the development of therapeutic agents for breast cancer from natural products.
乳腺癌是最常见的恶性肿瘤,也是全球妇女死亡的主要原因。Atramacronoid A (AM-A) 是一种独特的天然倍半萜内酯,从白术根茎中分离出来。我们的研究表明,AM-A 能引发一种特殊形式的细胞死亡,类似于 PANoptosis 样细胞死亡。进一步的分析表明,AM-A诱导的PAN凋亡样细胞死亡与线粒体功能障碍介导的CASP-3/PARP-GSDMD-MLKL通路有关。这些结果表明,AM-A 有可能成为一种先导化合物,并为从天然产品中开发乳腺癌治疗药物提供了启示。
{"title":"Atramacronoid A induces the PANoptosis-like cell death of human breast cancer cells through the CASP-3/PARP-GSDMD-MLKL pathways.","authors":"Jing-Rong Li, Ling-Yu Li, Hai-Xin Zhang, Ming-Qin Zhong, Zhong-Mei Zou","doi":"10.1080/10286020.2024.2368841","DOIUrl":"https://doi.org/10.1080/10286020.2024.2368841","url":null,"abstract":"<p><p>Breast cancer is the most common malignant tumor and a major cause of mortality among women worldwide. Atramacronoid A (AM-A) is a unique natural sesquiterpene lactone isolated from the rhizome of <i>Atractylodes macrocephala</i> Koidz (known as Baizhu in Chinese). Our study demonstrated that AM-A triggers a specific form of cell death resembling PANoptosis-like cell death. Further analysis indicated that AM-A-induced PANoptosis-like cell death is associated with the CASP-3/PARP-GSDMD-MLKL pathways, which are mediated by mitochondrial dysfunction. These results suggest the potential of AM-A as a lead compound and offer insights for the development of therapeutic agents for breast cancer from natural products.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141492121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Boswellia sacra has the properties of activating blood circulation, fixing pain, subduing swelling and promoting muscle growth. However, the anti-inflammatory active ingredients and molecular mechanisms of Boswellia sacra are still not clearly explored. Boswellia sacra was grounded and extracted using 95% ethanol, the extracts were separated by column chromatography preparation to give compounds. Spectral analysis and quantum calculations confirmed the structures of compounds and identified compound 1 as a new compound. Compounds 1-3 showed potent inhibitory activities and their effects on inflammatory mediator NO and inflammatory cytokines were examined by ELISA assay. Furthermore, their modulatory mechanism on inflammatory signal pathways was explored.
乳香具有活血、止痛、消肿和促进肌肉生长的功效。然而,乳香的抗炎活性成分和分子机制仍未得到明确的探索。将乳香磨碎并用 95% 的乙醇提取,提取物经柱层析分离得到化合物。光谱分析和量子计算证实了化合物的结构,并确定化合物 1 为新化合物。通过酶联免疫吸附试验检测了化合物 1-3 对炎症介质 NO 和炎症细胞因子的影响。此外,还探讨了它们对炎症信号通路的调节机制。
{"title":"New cembranoid with potent anti-inflammatory effect isolated from <i>Boswellia sacra</i> by inactivating the NF-κB signaling pathway.","authors":"Xiao-Rong Yin, Zhen Yuan, Wei-Feng Wang, Bing-Yang Zhang, Lu-Qiong Wang, Feng Qiu, Feng Zhao","doi":"10.1080/10286020.2024.2372390","DOIUrl":"https://doi.org/10.1080/10286020.2024.2372390","url":null,"abstract":"<p><p><i>Boswellia sacra</i> has the properties of activating blood circulation, fixing pain, subduing swelling and promoting muscle growth. However, the anti-inflammatory active ingredients and molecular mechanisms of <i>Boswellia sacra</i> are still not clearly explored. <i>Boswellia sacra</i> was grounded and extracted using 95% ethanol, the extracts were separated by column chromatography preparation to give compounds. Spectral analysis and quantum calculations confirmed the structures of compounds and identified compound <b>1</b> as a new compound. Compounds <b>1</b>-<b>3</b> showed potent inhibitory activities and their effects on inflammatory mediator NO and inflammatory cytokines were examined by ELISA assay. Furthermore, their modulatory mechanism on inflammatory signal pathways was explored.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141492124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.1080/10286020.2024.2368835
S T Shukla, Anu Kaushik, Samiullah Allahbaksh Auti, Dinesh Kumar, Supriya Kumar Das
This study investigated the effects of halibut oil cream, containing omega-3 fatty acids, vitamins A and D, and hydroxyproline, on burn wound healing in rats. Acute dermal toxicity tests confirmed its nontoxicity. Wistar rats were divided into five groups: a control, a positive control treated with silver sulfadiazine 1% (SSD), and three groups treated with 3%, 9%, and 27% halibut oil cream Formulation (HBOF). The SSD and HBOF groups showed significant healing improvements compared to the control. Histopathological analysis indicated increased collagen production in the HBOF groups, suggesting halibut oil cream's potential as a topical treatment for burn wounds.
本研究调查了含有欧米茄-3 脂肪酸、维生素 A 和 D 以及羟脯氨酸的比目鱼油膏对大鼠烧伤伤口愈合的影响。急性皮肤毒性试验证实其无毒性。Wistar 大鼠被分为五组:一组为对照组,一组为使用 1%磺胺嘧啶银(SSD)治疗的阳性对照组,三组分别使用 3%、9% 和 27% 的大比目鱼油膏配方(HBOF)治疗。与对照组相比,磺胺嘧啶银组和比目鱼油膏组的愈合效果显著。组织病理学分析表明,HBOF 组的胶原蛋白生成增加,这表明大比目鱼油膏具有局部治疗烧伤创面的潜力。
{"title":"Preclinical determination of wound-healing activity of halibut oil cream in rat model of burn wound.","authors":"S T Shukla, Anu Kaushik, Samiullah Allahbaksh Auti, Dinesh Kumar, Supriya Kumar Das","doi":"10.1080/10286020.2024.2368835","DOIUrl":"https://doi.org/10.1080/10286020.2024.2368835","url":null,"abstract":"<p><p>This study investigated the effects of halibut oil cream, containing omega-3 fatty acids, vitamins A and D, and hydroxyproline, on burn wound healing in rats. Acute dermal toxicity tests confirmed its nontoxicity. Wistar rats were divided into five groups: a control, a positive control treated with silver sulfadiazine 1% (SSD), and three groups treated with 3%, 9%, and 27% halibut oil cream Formulation (HBOF). The SSD and HBOF groups showed significant healing improvements compared to the control. Histopathological analysis indicated increased collagen production in the HBOF groups, suggesting halibut oil cream's potential as a topical treatment for burn wounds.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141468156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01DOI: 10.1080/10286020.2024.2369279
Da-Min Jung, Sangsoo Lee, Eun-Mi Kim, Chong Won Choi, Kee K Kim
Inhibition of lipid synthesis in sebocytes is essential for acne treatments. The effects of natural product-derived substances on lipid synthesis are unknown. This study investigated the effects of water extract of Mangifera indica leaves (WEML) on lipid synthesis in human sebocytes. Sebocyte differentiation in low serum conditions increased lipid accumulation and proliferator-activated receptor γ expression. WEML treatment significantly inhibited lipid accumulation and adipogenic mRNA expression in sebocytes. Mangiferin, a bioactive compound in WEML, also reduced lipid accumulation and adipogenic mRNA expression via the AKT pathway. Thus, WEML and mangiferin effectively inhibit lipid synthesis in sebocytes, showing promise for acne treatment.
{"title":"Mangiferin, a component of <i>Mangifera indica</i> leaf extracts, inhibits lipid synthesis in human sebocytes.","authors":"Da-Min Jung, Sangsoo Lee, Eun-Mi Kim, Chong Won Choi, Kee K Kim","doi":"10.1080/10286020.2024.2369279","DOIUrl":"https://doi.org/10.1080/10286020.2024.2369279","url":null,"abstract":"<p><p>Inhibition of lipid synthesis in sebocytes is essential for acne treatments. The effects of natural product-derived substances on lipid synthesis are unknown. This study investigated the effects of water extract of <i>Mangifera indica</i> leaves (WEML) on lipid synthesis in human sebocytes. Sebocyte differentiation in low serum conditions increased lipid accumulation and proliferator-activated receptor γ expression. WEML treatment significantly inhibited lipid accumulation and adipogenic mRNA expression in sebocytes. Mangiferin, a bioactive compound in WEML, also reduced lipid accumulation and adipogenic mRNA expression via the AKT pathway. Thus, WEML and mangiferin effectively inhibit lipid synthesis in sebocytes, showing promise for acne treatment.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141476652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-01Epub Date: 2024-03-28DOI: 10.1080/10286020.2024.2334547
{"title":"Correction.","authors":"","doi":"10.1080/10286020.2024.2334547","DOIUrl":"10.1080/10286020.2024.2334547","url":null,"abstract":"","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140305781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-30DOI: 10.1080/10286020.2024.2362383
Si-Yuan Li, Jiang-Shan Guo, Ya-Jun Yang
Histone deacetylase 6 (HDAC6) was a potential target for Alzheimer's disease (AD). In this study, a series of novel oxyevodiamine-based HDAC6 inhibitors with a variety of linker moieties were designed, synthesized and evaluated. Compound 12 with a benzyl linker was identified as a high potent and selective HDAC6 inhibitor. It inhibited HDAC6 with an IC50 value of 6.2 nM and was more than 200 fold selectivity over HDAC1. It also had lower cytotoxicity and higher anti-H2O2 activity in vitro comparing with other derivatives. Compound 12 might be a good lead as novel HDAC6 inhibitor for the treatment of AD.
{"title":"Design, synthesis and biological activity of oxyevodiamine-based histone deacetylase 6 inhibitors.","authors":"Si-Yuan Li, Jiang-Shan Guo, Ya-Jun Yang","doi":"10.1080/10286020.2024.2362383","DOIUrl":"https://doi.org/10.1080/10286020.2024.2362383","url":null,"abstract":"<p><p>Histone deacetylase 6 (HDAC6) was a potential target for Alzheimer's disease (AD). In this study, a series of novel oxyevodiamine-based HDAC6 inhibitors with a variety of linker moieties were designed, synthesized and evaluated. Compound <b>12</b> with a benzyl linker was identified as a high potent and selective HDAC6 inhibitor. It inhibited HDAC6 with an IC<sub>50</sub> value of 6.2 nM and was more than 200 fold selectivity over HDAC1. It also had lower cytotoxicity and higher anti-H<sub>2</sub>O<sub>2</sub> activity <i>in vitro</i> comparing with other derivatives. Compound <b>12</b> might be a good lead as novel HDAC6 inhibitor for the treatment of AD.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141468153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In this study, a previously undescribed cassane diterpenoid, named caesalpinin JF (1), along with two known cassane diterpenoids caesanine C (2) and tomocinol B (3), was isolated from 95% EtOH extract of the seeds of Caesalpinia sappan Linn. Additionally, three known compounds including pulcherrin R (4), syringaresinol-4'-O-β-D-glucopyranoside (5) and kaempferol (6) were also identified. The structures of the isolated compounds were elucidated by comprehensive 1D and 2D NMR spectroscopic analyses. Additionally, electronic circular dichroism (ECD) calculation was used to identify the absolute structure of compound 1. Among the isolated compounds, compound 1 displayed a potent anti-neuroinflammation with an IC50 value of 9.87 ± 1.71 μM.
在这项研究中,从红豆杉种子 95% 的 EtOH 提取物中分离出了一种之前未曾描述过的决明子二萜,命名为 Caesalpinin JF (1),以及两种已知的决明子二萜 caesanine C (2) 和 tomocinol B (3)。此外,还鉴定出三种已知化合物,包括 Pulcherrin R (4)、Syringaresinol-4'-O-β-D-吡喃葡萄糖苷 (5) 和山奈酚 (6)。通过全面的一维和二维核磁共振光谱分析,阐明了这些分离化合物的结构。在分离出的化合物中,化合物 1 具有很强的抗神经发炎作用,其 IC50 值为 9.87 ± 1.71 μM。
{"title":"A new cassane diterpenoid from the seed of <i>Caesalpinia sappan</i>.","authors":"Yue-Lin Zhao, Yue Jin, Zi-Ying Han, Wen-Han Song, Hui-Lin Zhu, Jian Zhang, Qian Wang, Miao Wang, Xiao-Wen Jiang, Hui-Yuan Gao","doi":"10.1080/10286020.2024.2360640","DOIUrl":"https://doi.org/10.1080/10286020.2024.2360640","url":null,"abstract":"<p><p>In this study, a previously undescribed cassane diterpenoid, named caesalpinin JF (<b>1</b>), along with two known cassane diterpenoids caesanine C (<b>2</b>) and tomocinol B (<b>3</b>), was isolated from 95% EtOH extract of the seeds of <i>Caesalpinia sappan</i> Linn. Additionally, three known compounds including pulcherrin R (<b>4</b>), syringaresinol-4'-<i>O</i>-<i>β</i>-D-glucopyranoside (<b>5</b>) and kaempferol (<b>6</b>) were also identified. The structures of the isolated compounds were elucidated by comprehensive 1D and 2D NMR spectroscopic analyses. Additionally, electronic circular dichroism (ECD) calculation was used to identify the absolute structure of compound <b>1</b>. Among the isolated compounds, compound <b>1</b> displayed a potent anti-neuroinflammation with an IC<sub>50</sub> value of 9.87 ± 1.71 <i>μ</i>M.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141468142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}