Pub Date : 2025-01-10DOI: 10.1080/10286020.2024.2441773
Ya-Kun Zhang, Zhan Xue, Jian-Bo Tong, Jing Tan, Min Yang, Yan-Rong Zeng, Cheng-Jian Tan
Three compounds, including a novel quinolizidine alkaloid, ochrocephalamine G (1), were isolated from Oxytropis ochrocephala. Structural elucidation was achieved through spectroscopic analysis and electronic circular dichroism. Biological assays showed that ochrocephalamine G (100 μM) inhibited HBsAg and HBeAg by 8.28% and 16.17%, respectively. Computational studies, including molecular docking and dynamics simulations, revealed its binding mode with HBV core protein, providing a solid foundation for developing O. ochrocephala as an anti-HBV therapeutic agent.
{"title":"Exploration and computational assessment of ochrocephalamine G from <i>Oxytropis ochrocephala</i> as an anti-HBV candidate.","authors":"Ya-Kun Zhang, Zhan Xue, Jian-Bo Tong, Jing Tan, Min Yang, Yan-Rong Zeng, Cheng-Jian Tan","doi":"10.1080/10286020.2024.2441773","DOIUrl":"https://doi.org/10.1080/10286020.2024.2441773","url":null,"abstract":"<p><p>Three compounds, including a novel quinolizidine alkaloid, ochrocephalamine G (<b>1</b>), were isolated from <i>Oxytropis ochrocephala</i>. Structural elucidation was achieved through spectroscopic analysis and electronic circular dichroism. Biological assays showed that ochrocephalamine G (100 μM) inhibited HBsAg and HBeAg by 8.28% and 16.17%, respectively. Computational studies, including molecular docking and dynamics simulations, revealed its binding mode with HBV core protein, providing a solid foundation for developing <i>O. ochrocephala</i> as an anti-HBV therapeutic agent.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-14"},"PeriodicalIF":1.3,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142949419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-10DOI: 10.1080/10286020.2024.2446280
Wahyu Safriansyah, Endang Juliansyah, Rustaman, Al Arofatus Naini, Kindi Farabi, Mohamad Nurul Azmi, Mohamad Azlan Nafiah, Hadi Kuncoro, Unang Supratman, Sofa Fajriah, Desi Harneti
Aglaia pachyphylla is a species from the Aglaia genus (Meliaceae) and the chemical constituent has not been widely explored. A new cycloartane-type triterpenoid, pachyphyllanone (1), along with four known compounds (2-5) were isolated from Aglaia pachyphylla Miq. Furthermore, the structure of the new compound was elucidated by the interpretation of spectroscopic data, including 1D and 2D-NMR, as well as ECD and NMR calculations (DP4+ analysis). Compounds 1-5 showed cytotoxic activities against MCF-7 with IC50 values ranging from 160.74 to 299.75 μM.
{"title":"Pachyphyllanone, a new cycloartane triterpenoid isolated from <i>Aglaia pachyphylla</i> and its cytotoxic activity.","authors":"Wahyu Safriansyah, Endang Juliansyah, Rustaman, Al Arofatus Naini, Kindi Farabi, Mohamad Nurul Azmi, Mohamad Azlan Nafiah, Hadi Kuncoro, Unang Supratman, Sofa Fajriah, Desi Harneti","doi":"10.1080/10286020.2024.2446280","DOIUrl":"https://doi.org/10.1080/10286020.2024.2446280","url":null,"abstract":"<p><p><i>Aglaia pachyphylla</i> is a species from the <i>Aglaia</i> genus (Meliaceae) and the chemical constituent has not been widely explored. A new cycloartane-type triterpenoid, pachyphyllanone (<b>1</b>), along with four known compounds (<b>2</b>-<b>5</b>) were isolated from <i>Aglaia pachyphylla</i> Miq. Furthermore, the structure of the new compound was elucidated by the interpretation of spectroscopic data, including 1D and 2D-NMR, as well as ECD and NMR calculations (DP4+ analysis). Compounds <b>1</b>-<b>5</b> showed cytotoxic activities against MCF-7 with IC<sub>50</sub> values ranging from 160.74 to 299.75 μM.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.3,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142949422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-09DOI: 10.1080/10286020.2024.2448011
Ayşe Nur Pektaş, Ertan Mahir Korkmaz
Antimicrobial peptides are crucial components of the immune systems of both vertebrates and invertebrates. Here, defensins, the most studied class of antimicrobial molecules in arthropods were investigated in four coleopteran insect species: Harpalus rufipes (DeGeer, 1774), Mylabris quadripunctata (Linnaeus, 1767), Sphaeridium marginatum (Linnaeus, 1758), and Ocypus mus (Brullé, 1832). The peptides synthesized with over 95% purity and their antimicrobial activities were evaluated by MIC test method. As a result, it was determined that Mylabris quadripunctata defensin (MqDef) showed high antimicrobial activity against Staphylococcus aureus and MRSA, whereas Sphaeridium marginatum (SmDef) and Harpalus rufipes (HrDef) defensins against Candida tropicalis.
{"title":"Novel antimicrobial defensin peptides from different coleopteran insects (Coleoptera: Insecta): identification, characterisation and antimicrobial properties.","authors":"Ayşe Nur Pektaş, Ertan Mahir Korkmaz","doi":"10.1080/10286020.2024.2448011","DOIUrl":"https://doi.org/10.1080/10286020.2024.2448011","url":null,"abstract":"<p><p>Antimicrobial peptides are crucial components of the immune systems of both vertebrates and invertebrates. Here, defensins, the most studied class of antimicrobial molecules in arthropods were investigated in four coleopteran insect species: <i>Harpalus rufipes</i> (DeGeer, 1774), <i>Mylabris quadripunctata</i> (Linnaeus, 1767), <i>Sphaeridium marginatum</i> (Linnaeus, 1758), and <i>Ocypus mus</i> (Brullé, 1832). The peptides synthesized with over 95% purity and their antimicrobial activities were evaluated by MIC test method. As a result, it was determined that <i>Mylabris quadripunctata</i> defensin (MqDef) showed high antimicrobial activity against <i>Staphylococcus aureus</i> and MRSA, whereas <i>Sphaeridium marginatum</i> (SmDef) and <i>Harpalus rufipes</i> (HrDef) defensins against <i>Candida tropicalis</i>.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-15"},"PeriodicalIF":1.3,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142949421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-02DOI: 10.1080/10286020.2024.2411704
Xue-Yan Huo , Meng-Dan Liu , Yu-Hui Chen , Yun-Jie Hu , Chen-Yi Yan , Da-Le Guo , Yu-Cheng Gu , Li-Jun Huang , Yun Deng
Three previously undescribed coumarins (1–3) were obtained from the roots of Notopterygium incisum. Their chemical structures were elucidated using a variety of spectroscopic techniques and chemical calculations. The inhibitory effects of these new compounds on NO production and pro-inflammatory factors (IL-1β, IL-6, and TNF-α) in LPS-stimulated RAW 264.7 cells were investigated. Further studies revealed that compound 1 suppressed the expression of COX-2 and iNOS while also reduced ROS accumulation. Western blot analysis demonstrated that compound 1 could inhibit the PI3K/AKT pathway by decreasing the levels of p-PI3K and p-AKT. Collectively, these findings suggest that compounds 1–3 exhibit promising anti-inflammatory properties.
{"title":"Three new coumarins from Notopterygium incisum with potential anti-inflammatory activity","authors":"Xue-Yan Huo , Meng-Dan Liu , Yu-Hui Chen , Yun-Jie Hu , Chen-Yi Yan , Da-Le Guo , Yu-Cheng Gu , Li-Jun Huang , Yun Deng","doi":"10.1080/10286020.2024.2411704","DOIUrl":"10.1080/10286020.2024.2411704","url":null,"abstract":"<div><div>Three previously undescribed coumarins (<strong>1</strong>–<strong>3</strong>) were obtained from the roots of <em>Notopterygium incisum</em>. Their chemical structures were elucidated using a variety of spectroscopic techniques and chemical calculations. The inhibitory effects of these new compounds on NO production and pro-inflammatory factors (<em>IL-1β</em>, <em>IL-6</em>, and <em>TNF-α</em>) in LPS-stimulated RAW 264.7 cells were investigated. Further studies revealed that compound <strong>1</strong> suppressed the expression of COX-2 and iNOS while also reduced ROS accumulation. Western blot analysis demonstrated that compound <strong>1</strong> could inhibit the PI3K/AKT pathway by decreasing the levels of p-PI3K and p-AKT. Collectively, these findings suggest that compounds <strong>1</strong>–<strong>3</strong> exhibit promising anti-inflammatory properties.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 1","pages":"Pages 18-30"},"PeriodicalIF":1.3,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142380935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-02DOI: 10.1080/10286020.2024.2421918
Sheng-Li Niu , Xiao-Zhuo Han , Yan-Ping Wang , Jia-Hui Hao , Fei Mo , Can-Can Cui , Ying-Yu Wang , Lu-Yao Zhang , Ya-Ting Sun
In order to make more rational use of Flemingia Philippinensis, a systematic separation from the roots of F. philippinensis was performed in the current study. The investigation of chemical constituents resulted in the isolation of a rare prenylated isoflavone-quinone, fleminquinone A (1), together with four known analogues (2–5). Their structures were established by extensive physical and spectroscopic data analysis. Anti-inflammatory activities of the isolated compounds were evaluated in lipopolysaccharide induced mouse mononuclear macrophage leukemia cells RAW 264.7 model. Compound 1 exhibited significant inhibitory effects on LPS-induced NO production and COX-2. Compound 1 also significantly affected the levels of inflammatory cytokines.
为了更合理地利用菲律宾佛兰芒，本研究对菲律宾佛兰芒的根部进行了系统分离。通过对化学成分的研究，分离出了一种罕见的前炔基异黄酮醌，即 Fleminquinone A（1），以及四种已知的类似物（2-5）。通过大量的物理和光谱数据分析，确定了它们的结构。在脂多糖诱导的小鼠单核巨噬细胞白血病细胞 RAW 264.7 模型中评估了分离化合物的抗炎活性。化合物 1 对 LPS 诱导的 NO 生成和 COX-2 具有明显的抑制作用。化合物 1 还能明显影响炎性细胞因子的水平。
{"title":"A rare prenylated isoflavone-quinone from the roots of Flemingia philippinensis","authors":"Sheng-Li Niu , Xiao-Zhuo Han , Yan-Ping Wang , Jia-Hui Hao , Fei Mo , Can-Can Cui , Ying-Yu Wang , Lu-Yao Zhang , Ya-Ting Sun","doi":"10.1080/10286020.2024.2421918","DOIUrl":"10.1080/10286020.2024.2421918","url":null,"abstract":"<div><div>In order to make more rational use of <em>Flemingia Philippinensis</em>, a systematic separation from the roots of <em>F. philippinensis</em> was performed in the current study. The investigation of chemical constituents resulted in the isolation of a rare prenylated isoflavone-quinone, fleminquinone A (<strong>1</strong>), together with four known analogues (<strong>2–5</strong>). Their structures were established by extensive physical and spectroscopic data analysis. Anti-inflammatory activities of the isolated compounds were evaluated in lipopolysaccharide induced mouse mononuclear macrophage leukemia cells RAW 264.7 model. Compound <strong>1</strong> exhibited significant inhibitory effects on LPS-induced NO production and COX-2. Compound <strong>1</strong> also significantly affected the levels of inflammatory cytokines.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 1","pages":"Pages 98-105"},"PeriodicalIF":1.3,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142557903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-02DOI: 10.1080/10286020.2024.2379978
Hao Chen , Sheng-Hong Li , Yong-Xian Cheng
Five undescribed compounds, including a triterpenoid (1), three phenylpropanoids [(±)−2 and 4], and an aromatic compound (3), as well as six known analogues (5–10), were isolated from the resins of Liquidambar orientalis Mill. Their structures, including absolute configurations, were determined by using spectroscopic and computational methods, and the five new compounds displayed anti-inflammatory activities in LPS-induced RAW264.7 cells.
{"title":"Five anti-inflammatory compounds from the resins of Liquidambar orientalis","authors":"Hao Chen , Sheng-Hong Li , Yong-Xian Cheng","doi":"10.1080/10286020.2024.2379978","DOIUrl":"10.1080/10286020.2024.2379978","url":null,"abstract":"<div><div>Five undescribed compounds, including a triterpenoid (<strong>1</strong>), three phenylpropanoids [(±)−<strong>2</strong> and <strong>4</strong>], and an aromatic compound (<strong>3</strong>), as well as six known analogues (<strong>5</strong>–<strong>10</strong>), were isolated from the resins of <em>Liquidambar orientalis</em> Mill. Their structures, including absolute configurations, were determined by using spectroscopic and computational methods, and the five new compounds displayed anti-inflammatory activities in LPS-induced RAW264.7 cells.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 1","pages":"Pages 1-10"},"PeriodicalIF":1.3,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141774688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-02DOI: 10.1080/10286020.2024.2428797
Bai-Xiang Cai , Qing-Yang Wu , Jin-Lian Huang , Jing Wu , Yang Yu , Lei Xiao , Xiang-Hai Cai
Looking for materials from Scutellaria baicalensis to improve oral inflammation and eliminate bad breath led to one new compound, 5,7,2′,5′-tetrahydroxy-6′-methoxyflavone (1) and 32 known ones. Among of them, 3 flavones (11, 17, 18), 2 dihydroflavones (23, 25), 2 flavone glucosides (30, 32), and a chalcone (26) could inhibit oral anaerobic bacteria Fusobacterium nucleatum, Streptococcus mutans, and Porphyromonas gingivalis. Compounds 3, 14, 18 could inhibit oral bacterial Staphylococcus aureus. Compounds 5, 8, 13 and 21 exhibited strong inhibitory NO production. Additionally, 14 and 26 showed good COX-1/2 inhibitory effects. These results indicated S. baicalensis has potential oral health benefits.
{"title":"Oral health promotion of flavonoids from Scutellaria baicalensis","authors":"Bai-Xiang Cai , Qing-Yang Wu , Jin-Lian Huang , Jing Wu , Yang Yu , Lei Xiao , Xiang-Hai Cai","doi":"10.1080/10286020.2024.2428797","DOIUrl":"10.1080/10286020.2024.2428797","url":null,"abstract":"<div><div>Looking for materials from <em>Scutellaria baicalensis</em> to improve oral inflammation and eliminate bad breath led to one new compound, 5,7,2′,5′-tetrahydroxy-6′-methoxyflavone (<strong>1</strong>) and 32 known ones. Among of them, 3 flavones (<strong>11</strong>, <strong>17</strong>, <strong>18</strong>), 2 dihydroflavones (<strong>23</strong>, <strong>25</strong>), 2 flavone glucosides (<strong>30</strong>, <strong>32</strong>), and a chalcone (<strong>26</strong>) could inhibit oral anaerobic bacteria <em>Fusobacterium nucleatum</em>, <em>Streptococcus mutans</em>, and <em>Porphyromonas gingivalis</em>. Compounds <strong>3, 14</strong>, <strong>18</strong> could inhibit oral bacterial <em>Staphylococcus aureus</em>. Compounds <strong>5</strong>, <strong>8</strong>, <strong>13</strong> and <strong>21</strong> exhibited strong inhibitory NO production. Additionally, <strong>14</strong> and <strong>26</strong> showed good COX-1/2 inhibitory effects. These results indicated <em>S. baicalensis</em> has potential oral health benefits.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 1","pages":"Pages 88-97"},"PeriodicalIF":1.3,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142716182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-02DOI: 10.1080/10286020.2024.2371050
Xing-Hua Yuan , Su-Fang Zhang , Yu Hang , Yan-Hua Shen , Shan-Fang Zhang , Wei-Ling Huang , Jing-Yi Huang , Ye-Chang Qian , Xiu-Lian Zhang , Qiu-Hong Li , Li Li
Fuzheng Huayu recipe (FZHYR) is a Chinese patent medicine for the treatment of fibrosis. The effects of FZHYR on pulmonary fibrosis and macrophage polarization were investigated in vitro. FZHYR inhibited pulmonary inflammation and fibrosis and M2 polarization of macrophages in bleomycin-induced pulmonary fibrosis (BPF) of rat model. Differentially expressed genes were screened by high-throughput mRNA sequencing and GSEA showed that oxidative phosphorylation (OXPHOS) was correlated with BPF. FZHYR inhibited expressions of Ndufa2 and Ndufa6 in lung tissues of BPF rats. These findings suggest that OXPHOS pathway serves as a possible target for pulmonary fibrosis therapy by FZHYR.
{"title":"Fuzheng Huayu recipe inhibits bleomycin-induced pulmonary fibrosis in rats by inhibiting M2 polarization of macrophages via the oxidative phosphorylation pathway","authors":"Xing-Hua Yuan , Su-Fang Zhang , Yu Hang , Yan-Hua Shen , Shan-Fang Zhang , Wei-Ling Huang , Jing-Yi Huang , Ye-Chang Qian , Xiu-Lian Zhang , Qiu-Hong Li , Li Li","doi":"10.1080/10286020.2024.2371050","DOIUrl":"10.1080/10286020.2024.2371050","url":null,"abstract":"<div><div>Fuzheng Huayu recipe (FZHYR) is a Chinese patent medicine for the treatment of fibrosis. The effects of FZHYR on pulmonary fibrosis and macrophage polarization were investigated <em>in vitro</em>. FZHYR inhibited pulmonary inflammation and fibrosis and M2 polarization of macrophages in bleomycin-induced pulmonary fibrosis (BPF) of rat model. Differentially expressed genes were screened by high-throughput mRNA sequencing and GSEA showed that oxidative phosphorylation (OXPHOS) was correlated with BPF. FZHYR inhibited expressions of <em>Ndufa2</em> and <em>Ndufa6</em> in lung tissues of BPF rats. These findings suggest that OXPHOS pathway serves as a possible target for pulmonary fibrosis therapy by FZHYR.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 1","pages":"Pages 62-74"},"PeriodicalIF":1.3,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141492123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-02DOI: 10.1080/10286020.2024.2410460
Lu Rao , Fei Chen , Ming-Hui Gao , Jun-Jie Tan , Shi-Jin Qu , Chang-Heng Tan
Twelve monoterpene indole glycoalkaloids, comprising of three new ones, 19-epi-rhynchophylloside A (1), 7-epi-rhynchophylloside A (2), and 7-epi-anthocephalusine A (3), were isolated from the hook-bearing branches of Uncaria rhynchophylla. The structures and absolute configurations of 1–3 were elucidated by analysis of MS, NMR, ECD, and single-crystal X-ray diffraction or TDDFT-ECD calculations. Glycoalkaloids 1 and 3 showed significant immunosuppressive activity against the proliferation of B lymphocyte induced by LPS with broad selective index.
从钩吻科植物钩吻的生枝中分离出12种单萜烯吲哚糖生物碱，包括3种新的单萜烯吲哚糖生物碱，即19-epi-rhynchophylloside A (1)、7-epi-rhynchophylloside A (2)和7-epi-anthocephalusine A (3)。通过分析 MS、NMR、ECD 和单晶 X 射线衍射或 TDDFT-ECD 计算，阐明了 1-3 的结构和绝对构型。糖生物碱 1 和 3 对 LPS 诱导的 B 淋巴细胞增殖具有显著的免疫抑制活性，并具有广泛的选择性。
{"title":"Monoterpene indole glycoalkaloids from the hook-bearing branches of Uncaria rhynchophylla","authors":"Lu Rao , Fei Chen , Ming-Hui Gao , Jun-Jie Tan , Shi-Jin Qu , Chang-Heng Tan","doi":"10.1080/10286020.2024.2410460","DOIUrl":"10.1080/10286020.2024.2410460","url":null,"abstract":"<div><div>Twelve monoterpene indole glycoalkaloids, comprising of three new ones, 19-<em>epi</em>-rhynchophylloside A (<strong>1</strong>), 7-<em>epi</em>-rhynchophylloside A (<strong>2</strong>), and 7-<em>epi</em>-anthocephalusine A (<strong>3</strong>), were isolated from the hook-bearing branches of <em>Uncaria rhynchophylla</em>. The structures and absolute configurations of <strong>1–3</strong> were elucidated by analysis of MS, NMR, ECD, and single-crystal X-ray diffraction or TDDFT-ECD calculations. Glycoalkaloids <strong>1</strong> and <strong>3</strong> showed significant immunosuppressive activity against the proliferation of B lymphocyte induced by LPS with broad selective index.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 1","pages":"Pages 31-37"},"PeriodicalIF":1.3,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142466287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-02DOI: 10.1080/10286020.2024.2361767
Fu-Hong Liu , Xing-Cheng Lin , Yu-Wei Liu , Tian-Tian Zhang , Yang-Bo Zhang , Zhuo-Long Xie , Yuan Zhan , Ping Hu
Harmine is present in a variety of medicinal plants, and its effects on colon cancer cells remain unclear. Here, we found that harmine exhibited significant inhibitory effects on the proliferation of colon cancer cells by inhibiting the phosphorylation levels of the FAK/AKT and ERK1/2/CREB. Furthermore, harmine also inhibited the migration of colon cancer cells and suppressed the expression levels of MMP-2, MMP-9, and VEGF. Additionally, harmine-induced apoptosis in colon cancer cells by regulating the expression of Bcl-2 and Bax. In conclusion, our findings suggest that harmine exerts a significant inhibitory effect on the development of colon cancer cells.
{"title":"Harmine inhibits the proliferation and migration and promotes the apoptosis of colon cancer cells via inhibition of the FAK/AKT and ERK1/2/CREB signaling pathways","authors":"Fu-Hong Liu , Xing-Cheng Lin , Yu-Wei Liu , Tian-Tian Zhang , Yang-Bo Zhang , Zhuo-Long Xie , Yuan Zhan , Ping Hu","doi":"10.1080/10286020.2024.2361767","DOIUrl":"10.1080/10286020.2024.2361767","url":null,"abstract":"<div><div>Harmine is present in a variety of medicinal plants, and its effects on colon cancer cells remain unclear. Here, we found that harmine exhibited significant inhibitory effects on the proliferation of colon cancer cells by inhibiting the phosphorylation levels of the FAK/AKT and ERK1/2/CREB. Furthermore, harmine also inhibited the migration of colon cancer cells and suppressed the expression levels of MMP-2, MMP-9, and VEGF. Additionally, harmine-induced apoptosis in colon cancer cells by regulating the expression of Bcl-2 and Bax. In conclusion, our findings suggest that harmine exerts a significant inhibitory effect on the development of colon cancer cells.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"27 1","pages":"Pages 75-87"},"PeriodicalIF":1.3,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141603631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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