Zhachong-13 pills (ZC-13), as a traditional prescription of Mongolian medicine, are often used in the clinical practice of Mongolian hospitals for the treatment of stroke and rheumatic arthritis. In this experiment, UHPLC-Q-Exactive Orbitrap MS was used to explore the chemical composition of ZC-13. The results showed that 315 compounds were identified or inferred, including 56 alkaloids, 77 2-(2-phenylethyl)chromones, 61 flavonoids, 31 tannins, 8 coumarins, 16 lignans, 21 terpenoids, 5 amino acids, 19 organic acids, and 21 other components. In addition, the pharmacological activities related to anti-cerebral ischemia of these components were summarized. This result laid a foundation for further study on the pharmacodynamic material basis of ZC-13 and provided a scientific basis for the formulation of ZC-13 quality specifications.
{"title":"Online identification of chemical constituents in Mongolian medicine Zhachong-13 pills by UHPLC-Q-exactive Orbitrap MS.","authors":"Cai-Yun Tian, Qing-Rui Yang, Ling-Xuan Fan, Yu-Mei Yang, Bo-Wen Gao, Jian-Bo Yang","doi":"10.1080/10286020.2024.2379981","DOIUrl":"https://doi.org/10.1080/10286020.2024.2379981","url":null,"abstract":"<p><p>Zhachong-13 pills (ZC-13), as a traditional prescription of Mongolian medicine, are often used in the clinical practice of Mongolian hospitals for the treatment of stroke and rheumatic arthritis. In this experiment, UHPLC-Q-Exactive Orbitrap MS was used to explore the chemical composition of ZC-13. The results showed that 315 compounds were identified or inferred, including 56 alkaloids, 77 2-(2-phenylethyl)chromones, 61 flavonoids, 31 tannins, 8 coumarins, 16 lignans, 21 terpenoids, 5 amino acids, 19 organic acids, and 21 other components. In addition, the pharmacological activities related to anti-cerebral ischemia of these components were summarized. This result laid a foundation for further study on the pharmacodynamic material basis of ZC-13 and provided a scientific basis for the formulation of ZC-13 quality specifications.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141734179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-22DOI: 10.1080/10286020.2024.2378821
Hong-Ping Wang, Zhao-Zhou Lin, Qiong Yin, Jing Du
In our study, a method based on affinity ultrafiltration screening coupled with UPLC-ESI-Orbitrap-MS technology was established to select Glucagon-like peptide-1 receptor (GLP-1R) agonists from natural products, and as an example, the GLP-1R agonists from Panax ginseng was selected using our established method. As a result, total five GLP-1R agonists were selected from Panax ginseng for the first time. Our results indicated that activating GLP-1R to promote insulin secretion probably was another important hypoglycemia mechanism for ginsenosides in Panax ginseng, which had great influence on the study of the anti-diabetes effect of ginsenosides.
{"title":"Screening of GLP-1r agonists from natural products using affinity ultrafiltration screening coupled with UPLC-ESI-Orbitrap-MS technology: a case study of <i>Panax ginseng</i>.","authors":"Hong-Ping Wang, Zhao-Zhou Lin, Qiong Yin, Jing Du","doi":"10.1080/10286020.2024.2378821","DOIUrl":"https://doi.org/10.1080/10286020.2024.2378821","url":null,"abstract":"<p><p>In our study, a method based on affinity ultrafiltration screening coupled with UPLC-ESI-Orbitrap-MS technology was established to select Glucagon-like peptide-1 receptor (GLP-1R) agonists from natural products, and as an example, the GLP-1R agonists from <i>Panax ginseng</i> was selected using our established method. As a result, total five GLP-1R agonists were selected from <i>Panax ginseng</i> for the first time. Our results indicated that activating GLP-1R to promote insulin secretion probably was another important hypoglycemia mechanism for ginsenosides in <i>Panax ginseng</i>, which had great influence on the study of the anti-diabetes effect of ginsenosides.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141734181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Harmine is present in a variety of medicinal plants, and its effects on colon cancer cells remain unclear. Here, we found that harmine exhibited significant inhibitory effects on the proliferation of colon cancer cells by inhibiting the phosphorylation levels of the FAK/AKT and ERK1/2/CREB. Furthermore, harmine also inhibited the migration of colon cancer cells and suppressed the expression levels of MMP-2, MMP-9, and VEGF. Additionally, harmine-induced apoptosis in colon cancer cells by regulating the expression of Bcl-2 and Bax. In conclusion, our findings suggest that harmine exerts a significant inhibitory effect on the development of colon cancer cells.
{"title":"Harmine inhibits the proliferation and migration and promotes the apoptosis of colon cancer cells via inhibition of the FAK/AKT and ERK<sub>1/2</sub>/CREB signaling pathways.","authors":"Fu-Hong Liu, Xing-Cheng Lin, Yu-Wei Liu, Tian-Tian Zhang, Yang-Bo Zhang, Zhuo-Long Xie, Yuan Zhan, Ping Hu","doi":"10.1080/10286020.2024.2361767","DOIUrl":"https://doi.org/10.1080/10286020.2024.2361767","url":null,"abstract":"<p><p>Harmine is present in a variety of medicinal plants, and its effects on colon cancer cells remain unclear. Here, we found that harmine exhibited significant inhibitory effects on the proliferation of colon cancer cells by inhibiting the phosphorylation levels of the FAK/AKT and ERK1/2/CREB. Furthermore, harmine also inhibited the migration of colon cancer cells and suppressed the expression levels of MMP-2, MMP-9, and VEGF. Additionally, harmine-induced apoptosis in colon cancer cells by regulating the expression of Bcl-2 and Bax. In conclusion, our findings suggest that harmine exerts a significant inhibitory effect on the development of colon cancer cells.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141603631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-12DOI: 10.1080/10286020.2024.2376244
Guo-Qing Sun, Cheng-En Fu, Yang Yang, Xiao-Jian Li, Jia-Yi Ma, Shuai Huang, Xian-Li Zhou, Lin Chen
Three new diterpenoid alkaloids (1, 2, 3) and seventeen known (4-20) compounds were isolated from the whole plant of Delphinium sherriffii Munz (Ranunculaceae). Their structures were elucidated by various spectroscopic analyses, including IR, HR-ESI-MS, 1D and 2D NMR spectra. All compounds were evaluated for the inhibitory activity of Sf9 cells and compound 5 exhibited the strongest cytotoxicity (IC50 = 8.97 μM) against Sf9 cell line.
{"title":"Diterpenoid alkaloids from <i>Delphinium sherriffii</i>.","authors":"Guo-Qing Sun, Cheng-En Fu, Yang Yang, Xiao-Jian Li, Jia-Yi Ma, Shuai Huang, Xian-Li Zhou, Lin Chen","doi":"10.1080/10286020.2024.2376244","DOIUrl":"https://doi.org/10.1080/10286020.2024.2376244","url":null,"abstract":"<p><p>Three new diterpenoid alkaloids (<b>1</b>, <b>2</b>, <b>3</b>) and seventeen known (<b>4-20</b>) compounds were isolated from the whole plant of <i>Delphinium sherriffii</i> Munz (Ranunculaceae). Their structures were elucidated by various spectroscopic analyses, including IR, HR-ESI-MS, 1D and 2D NMR spectra. All compounds were evaluated for the inhibitory activity of Sf9 cells and compound <b>5</b> exhibited the strongest cytotoxicity (IC<sub>50</sub> = 8.97 μM) against Sf9 cell line.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141599920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-09DOI: 10.1080/10286020.2024.2375291
Xiao-Hui Wang, Peng-Fei Dong, Feng Wang, Lin Zhou
In this study, based on Walker 256 in vitro experiments, CCK-8 assay, clone formation assay, wound healing assay, and flow cytometry were used to detect cell apoptosis and cell cycle. It was found that schisandrin may have significant anti-tumor effects in vitro by inhibiting TGF-β/Smad signaling pathway. In addition, in vivo experiments, immunohistochemistry was used to observe the expression of HIF-1α, VEGF and VEGFR-2 in tumor tissues. It was found that schisandrin could significantly improve the immunosuppression induced by 5-Fu and enhance the antitumor effect of 5-Fu. The mechanism may be related to the inhibition of Wnt-1/β-catenin signaling pathway.
{"title":"Schisandrin A can promote the anti-tumor effect of 5-Fu by reversing the immunosuppressive state of the body in rat.","authors":"Xiao-Hui Wang, Peng-Fei Dong, Feng Wang, Lin Zhou","doi":"10.1080/10286020.2024.2375291","DOIUrl":"https://doi.org/10.1080/10286020.2024.2375291","url":null,"abstract":"<p><p>In this study, based on Walker 256 in vitro experiments, CCK-8 assay, clone formation assay, wound healing assay, and flow cytometry were used to detect cell apoptosis and cell cycle. It was found that schisandrin may have significant anti-tumor effects in vitro by inhibiting TGF-β/Smad signaling pathway. In addition, in vivo experiments, immunohistochemistry was used to observe the expression of HIF-1α, VEGF and VEGFR-2 in tumor tissues. It was found that schisandrin could significantly improve the immunosuppression induced by 5-Fu and enhance the antitumor effect of 5-Fu. The mechanism may be related to the inhibition of Wnt-1/β-catenin signaling pathway.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141558838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Three chromomycin derivatives, chromomycins A3 (1, CA3), A5 (2, CA5), and monodeacetylchromomycin A3 (3, MDA-CA3), were identified from the soil-derived Streptomyces sp. CGMCC 26516. A reinvestigation of the structure of CA5 is reported, of which the absolute configuration was unambiguously determined for the first time to be identical with that of CA3 based on nuclear magnetic resonance (NMR) data analysis as well as NMR and electronic circular dichroism calculations. Compounds 1-3 showed potent cytotoxicity against the non-small-cell lung cancer (NSCLC) cells (A549, H460, H157-c-FLIP, and H157-LacZ) and down-regulated the protein expression of c-FLIP in A549 cells. The IC50 values of chromomycins in H157-c-FLIP were higher than that in H157-LacZ. Furthermore, si-c-FLIP promoted anti-proliferation effect of chromomycins in NSCLC cells. In nude mice xenograft model, 1 and 2 both showed more potent inhibition on the growth of H157-lacZ xenografts than that of H157-c-FLIP xenografts. These results verify that c-FLIP mediates the anticancer effects of chromomycins in NSCLC.
{"title":"Chromomycins from soil-derived <i>Streptomyces</i> sp. inhibit the growth of human non-small cell lung cancer cells by targeting c-FLIP.","authors":"Gao-Jie Li, Chen Wang, Wen-Die Wang, Yue Shang, Chao-Yang Zeng, Ai-Min Wang, Jing-Lin Bai, Jing Su, Ling Su, Shu-Yi Si, Li-Yan Yu, Mao-Luo Gan, Shu-Zhen Chen","doi":"10.1080/10286020.2024.2375288","DOIUrl":"https://doi.org/10.1080/10286020.2024.2375288","url":null,"abstract":"<p><p>Three chromomycin derivatives, chromomycins A<sub>3</sub> (<b>1,</b> CA<sub>3</sub>), A<sub>5</sub> (<b>2,</b> CA<sub>5</sub>), and monodeacetylchromomycin A<sub>3</sub> (<b>3,</b> MDA-CA<sub>3</sub>), were identified from the soil-derived <i>Streptomyces</i> sp. CGMCC 26516. A reinvestigation of the structure of CA<sub>5</sub> is reported, of which the absolute configuration was unambiguously determined for the first time to be identical with that of CA<sub>3</sub> based on nuclear magnetic resonance (NMR) data analysis as well as NMR and electronic circular dichroism calculations. Compounds <b>1-3</b> showed potent cytotoxicity against the non-small-cell lung cancer (NSCLC) cells (A549, H460, H157-c-FLIP, and H157-LacZ) and down-regulated the protein expression of c-FLIP in A549 cells. The IC<sub>50</sub> values of chromomycins in H157-c-FLIP were higher than that in H157-LacZ. Furthermore, si-c-FLIP promoted anti-proliferation effect of chromomycins in NSCLC cells. In nude mice xenograft model, <b>1</b> and <b>2</b> both showed more potent inhibition on the growth of H157-lacZ xenografts than that of H157-c-FLIP xenografts. These results verify that c-FLIP mediates the anticancer effects of chromomycins in NSCLC.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141554886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-08DOI: 10.1080/10286020.2024.2373326
Jiang Hu, Ren Ji, Guang-Rong Yang, Tao Lv, Qiang Li, Feng Gao
A chemical investigation on the roots of Aconitum nagarum afforded two undescribed C19-diterpenoid alkaloids nagarumines D and E (1 and 2). The structures of the new compounds were elucidated by spectral methods such as 1D and 2D (1H-1H COSY, HMQC, and HMBC) NMR spectroscopy, as well as HR-ESI-MS. The two isolated alkaloids were tested in vitro for cytotoxic activity against five gastric tumor cell lines. Consequently, compound 2 exhibited some cytotoxicities against several human cancer cell lines with IC50 value less than 20.0 μM.
{"title":"Two new diterpenoid alkaloids from the roots of <i>Aconitum nagarum</i> and their cytotoxic activity.","authors":"Jiang Hu, Ren Ji, Guang-Rong Yang, Tao Lv, Qiang Li, Feng Gao","doi":"10.1080/10286020.2024.2373326","DOIUrl":"https://doi.org/10.1080/10286020.2024.2373326","url":null,"abstract":"<p><p>A chemical investigation on the roots of <i>Aconitum nagarum</i> afforded two undescribed C<sub>19</sub>-diterpenoid alkaloids nagarumines D and E (<b>1</b> and <b>2</b>). The structures of the new compounds were elucidated by spectral methods such as 1D and 2D (<sup>1</sup>H-<sup>1</sup>H COSY, HMQC, and HMBC) NMR spectroscopy, as well as HR-ESI-MS. The two isolated alkaloids were tested <i>in vitro</i> for cytotoxic activity against five gastric tumor cell lines. Consequently, compound <b>2</b> exhibited some cytotoxicities against several human cancer cell lines with IC<sub>50</sub> value less than 20.0 μM.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141554888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-08DOI: 10.1080/10286020.2024.2371040
Zhang Hui, Wang Lai-Fa, Wang Xue-Qin, Deng Ling, He Bin-Sheng, Jian-Ming Li
The flavonoid compound chinonin is one of the main active components of Rhizoma anemarrhena with multiple activities, including anti-inflammatory and antioxidant properties, protection of mitochondrial function and regulation of immunity. In this paper, we reviewed recent research progress on the protective effect of chinonin on brain injury in neurological diseases. "Chinonin" OR "Mangiferin" AND "Nervous system diseases" OR "Neuroprotection" was used as the terms for search in PumMed. After discarding duplicated and irrelevant articles, a total of 23 articles relevant to chinonin published between 2012 and 2023 were identified in our study.
{"title":"Mechanisms and therapeutic potential of chinonin in nervous system diseases.","authors":"Zhang Hui, Wang Lai-Fa, Wang Xue-Qin, Deng Ling, He Bin-Sheng, Jian-Ming Li","doi":"10.1080/10286020.2024.2371040","DOIUrl":"https://doi.org/10.1080/10286020.2024.2371040","url":null,"abstract":"<p><p>The flavonoid compound chinonin is one of the main active components of <i>Rhizoma anemarrhena</i> with multiple activities, including anti-inflammatory and antioxidant properties, protection of mitochondrial function and regulation of immunity. In this paper, we reviewed recent research progress on the protective effect of chinonin on brain injury in neurological diseases. \"Chinonin\" OR \"Mangiferin\" AND \"Nervous system diseases\" OR \"Neuroprotection\" was used as the terms for search in PumMed. After discarding duplicated and irrelevant articles, a total of 23 articles relevant to chinonin published between 2012 and 2023 were identified in our study.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141554887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-04DOI: 10.1080/10286020.2024.2370401
Xian-Sheng Ye, Kuan Lin, Chang-Long Leng, Yu-Ran Gui, Shu-Xiu Zhu, Hui-Ying Liu, Yi-Yuan Xia, Bin-Lian Sun, Wei Liu, Xi-Ji Shu
The preliminary study revealed that the ethyl acetate eluate of Youngia japonica (YJ-E) could inhibit the expression of key proteins of p-p65, p-IκBα, p-IKKα/β, and p-AKT in LPS stimulated BV2 cell. Further phytochemical study led to the isolation of eight compounds from YJ-E, including one new sesquiterpene lactone. Their structures were elucidated by several spectroscopic data, and comparing the NMR data of known compound. In addition, all of the isolates were evaluated for the anti-inflammatory effect. As a result, compounds 3 and 4 distinctly attenuated the expressions of p-IκBα, p-p65, and p-AKT in LPS stimulated BV2 cell, respectively.
{"title":"Discovery of sesquiterpene lactones with anti-inflammatory effect from <i>Youngia japonica</i>.","authors":"Xian-Sheng Ye, Kuan Lin, Chang-Long Leng, Yu-Ran Gui, Shu-Xiu Zhu, Hui-Ying Liu, Yi-Yuan Xia, Bin-Lian Sun, Wei Liu, Xi-Ji Shu","doi":"10.1080/10286020.2024.2370401","DOIUrl":"https://doi.org/10.1080/10286020.2024.2370401","url":null,"abstract":"<p><p>The preliminary study revealed that the ethyl acetate eluate of <i>Youngia japonica</i> (YJ-E) could inhibit the expression of key proteins of p-p65, p-IκBα, p-IKKα/β, and p-AKT in LPS stimulated BV2 cell. Further phytochemical study led to the isolation of eight compounds from YJ-E, including one new sesquiterpene lactone. Their structures were elucidated by several spectroscopic data, and comparing the NMR data of known compound. In addition, all of the isolates were evaluated for the anti-inflammatory effect. As a result, compounds <b>3</b> and <b>4</b> distinctly attenuated the expressions of p-IκBα, p-p65, and p-AKT in LPS stimulated BV2 cell, respectively.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141498137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-07-04DOI: 10.1080/10286020.2024.2366450
Bao Zhang, Hai-Hua Yuan, Jia Sun, Hang Xun, Jie Wang, Feng Qiu, Jian-Jun Wang, Xi Yao, Jin Wang, Wei Fan, Feng Tang
Five new glycosides, namely methyl 3-methoxybenzoate-4,5-di-O-β-D-glucopyranoside (1), (1aS,3aS,3R)-3-(4'-O-β-D-glucopyranosyl-3'-methoxyphenyl)-5,6-dioxa-bicyclo[3.3.0]octane-1-one (2), quinolin-4(1H)-one-3-O-β-D-glucopyranoside (3), 3-methoxy-propiophenone 4-O-(6'-β-D-xylopyranosyl)-β-D-glucopyranoside (4), methyl 3-methoxybenzoate 4-O-(6'-β-D-xylopyranosyl)-β-D-glucopyranoside (5), and one known compound, bambulignan B (6) were isolated from the culms of Phyllostachys nigra var. henonis. Their structures were determined using spectroscopic analysis. All compounds were evaluated for their DPPH radical scavenging activity. Compound 6 exhibited antioxidant activity with IC50 value of 59.5 μM (positive control, L-ascorbic acid, IC50 = 12.4 μM; 2,6-ditertbutyl-4-methyl phenol, IC50 = 11.8 μM).
{"title":"Five new glycosides from the culms of <i>Phyllostachys nigra</i> var. <i>henonis</i>.","authors":"Bao Zhang, Hai-Hua Yuan, Jia Sun, Hang Xun, Jie Wang, Feng Qiu, Jian-Jun Wang, Xi Yao, Jin Wang, Wei Fan, Feng Tang","doi":"10.1080/10286020.2024.2366450","DOIUrl":"https://doi.org/10.1080/10286020.2024.2366450","url":null,"abstract":"<p><p>Five new glycosides, namely methyl 3-methoxybenzoate-4,5-di-<i>O</i>-<i>β</i>-D-glucopyranoside <b>(1)</b>, (1a<i>S</i>,3a<i>S</i>,3<i>R</i>)-3-(4'-<i>O</i>-<i>β</i>-D-glucopyranosyl-3'-methoxyphenyl)-5,6-dioxa-bicyclo[3.3.0]octane-1-one <b>(2)</b>, quinolin-4(1<i>H</i>)-one-3-<i>O</i>-<i>β</i>-D-glucopyranoside <b>(3)</b>, 3-methoxy-propiophenone 4-<i>O</i>-(6'-<i>β</i>-D-xylopyranosyl)-<i>β</i>-D-glucopyranoside <b>(4)</b>, methyl 3-methoxybenzoate 4-<i>O</i>-(6'-<i>β</i>-D-xylopyranosyl)-<i>β</i>-D-glucopyranoside <b>(5)</b>, and one known compound, bambulignan B <b>(6)</b> were isolated from the culms of <i>Phyllostachys nigra</i> var<i>. henonis</i>. Their structures were determined using spectroscopic analysis. All compounds were evaluated for their DPPH radical scavenging activity. Compound <b>6</b> exhibited antioxidant activity with IC<sub>50</sub> value of 59.5 μM (positive control, L-ascorbic acid, IC<sub>50</sub> = 12.4 μM; 2,6-ditertbutyl-4-methyl phenol, IC<sub>50</sub> = 11.8 μM).</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":null,"pages":null},"PeriodicalIF":1.3,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141498138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}