Pub Date : 2026-01-02DOI: 10.1080/10286020.2025.2481291
Ling-Ling Zhen , Ming-Tong Hou , Sheng-Bao Wang
Salidroside is a traditional Chinese medicine with multiple pharmacological activities such as anti-inflammatory and antioxidant properties, while acute kidney injury (AKI) is a common sepsis-induced acute inflammatory response. Using transcriptomics combined with metabolomics, this study identifies arachidonic acid metabolism-associated ferroptosis as an important mechanism for salidroside to improve sepsis-induced AKI (SI-AKI).
{"title":"Salidroside attenuates sepsis-induced acute kidney injury by inhibiting ferroptosis","authors":"Ling-Ling Zhen , Ming-Tong Hou , Sheng-Bao Wang","doi":"10.1080/10286020.2025.2481291","DOIUrl":"10.1080/10286020.2025.2481291","url":null,"abstract":"<div><div>Salidroside is a traditional Chinese medicine with multiple pharmacological activities such as anti-inflammatory and antioxidant properties, while acute kidney injury (AKI) is a common sepsis-induced acute inflammatory response. Using transcriptomics combined with metabolomics, this study identifies arachidonic acid metabolism-associated ferroptosis as an important mechanism for salidroside to improve sepsis-induced AKI (SI-AKI).</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"28 1","pages":"Pages 142-156"},"PeriodicalIF":1.3,"publicationDate":"2026-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-02DOI: 10.1080/10286020.2025.2492353
Wei Chen , Tao Huang , Yan-Xi Jin , Si-Min Lei , Lu-Yao Wang , Yang Chen
A series of isoquinolone compounds Ia-Iq containing amide moiety were rationally designed and synthesized based-on isoquinolone alkaloids. Their structures were confirmed by 1H NMR,13C NMR and HRMS. Most of the title compounds showed medium to excellent antifungal activity in vitro at 50 mg/L. Especially, the EC50 of Im (13.155 mg/L) against P. piricola was slightly better than chlorothalonil (14.323 mg/L). The in vivo activity of Im against P. piricola on apples was comparable to chlorothalonil. Preliminary mechanistic exploration illustrated that Im strongly damage the mycelium morphology. Furthermore, molecular electrostatic potential and molecular docking analysis revealed that Im could interact with the residues of SDH via hydrogen bond.
{"title":"Design, synthesis, and mechanism study of novel natural-based isoquinolone derivatives as potential antifungal agents","authors":"Wei Chen , Tao Huang , Yan-Xi Jin , Si-Min Lei , Lu-Yao Wang , Yang Chen","doi":"10.1080/10286020.2025.2492353","DOIUrl":"10.1080/10286020.2025.2492353","url":null,"abstract":"<div><div>A series of isoquinolone compounds <strong>Ia-Iq</strong> containing amide moiety were rationally designed and synthesized based-on isoquinolone alkaloids. Their structures were confirmed by <sup>1</sup>H NMR,<sup>13</sup>C NMR and HRMS. Most of the title compounds showed medium to excellent antifungal activity <em>in vitro</em> at 50 mg/L. Especially, the EC<sub>50</sub> of <strong>Im</strong> (13.155 mg/L) against <em>P. piricola</em> was slightly better than chlorothalonil (14.323 mg/L). The <em>in vivo</em> activity of <strong>Im</strong> against <em>P. piricola</em> on apples was comparable to chlorothalonil. Preliminary mechanistic exploration illustrated that <strong>Im</strong> strongly damage the mycelium morphology. Furthermore, molecular electrostatic potential and molecular docking analysis revealed that <strong>Im</strong> could interact with the residues of SDH via hydrogen bond.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"28 1","pages":"Pages 60-73"},"PeriodicalIF":1.3,"publicationDate":"2026-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143992185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-02DOI: 10.1080/10286020.2025.2490108
Yu-Feng Chen , Wei Gong , Xue Sun
A chemical investigation on the leaves of Paederia Foetida resulted into the isolation of two new iridoid glycosides, paefoetines A and B (1 and 2). Structural elucidation of all the compounds was performed by spectral methods such as 1D and 2D (1H-1H COSY, HMQC, and HMBC) NMR spectroscopy. The two isolated iridoid glycosides were tested in vivo for their antinociceptive properties. As a result, 1 exhibited potent antinociceptive activity and its ED50 value (49.2 μmol/kg) was twofold less than those of the positive control drugs aspirin.
{"title":"Iridoid glycosides from the leaves of Paederia foetida and their antinociceptive activities","authors":"Yu-Feng Chen , Wei Gong , Xue Sun","doi":"10.1080/10286020.2025.2490108","DOIUrl":"10.1080/10286020.2025.2490108","url":null,"abstract":"<div><div>A chemical investigation on the leaves of <em>Paederia Foetida</em> resulted into the isolation of two new iridoid glycosides, paefoetines A and B (<strong>1</strong> and <strong>2</strong>). Structural elucidation of all the compounds was performed by spectral methods such as 1D and 2D (<sup>1</sup>H<em>-</em><sup>1</sup>H COSY, HMQC, and HMBC) NMR spectroscopy. The two isolated iridoid glycosides were tested <em>in vivo</em> for their antinociceptive properties. As a result, <strong>1</strong> exhibited potent antinociceptive activity and its ED<sub>50</sub> value (49.2 μmol/kg) was twofold less than those of the positive control drugs aspirin.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"28 1","pages":"Pages 53-59"},"PeriodicalIF":1.3,"publicationDate":"2026-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144019395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-02DOI: 10.1080/10286020.2025.2492357
Yue-Hui Huang , Lu Qiu , Yi Peng , Rui Cai , Qing-Qing Xiao , Mei-Chen Li , Li-Jia Xu , Qiang Fu
This study investigated the chemical compositions isolated from Cyathula officinalis (CES) and elucidated its anti-RA effects and potential mechanisms. In vitro results revealed that CES suppressed interleukin (IL)-1β-stimulated proliferation, migration, and invasion of MH7A cells in a concentration-dependent manner. In vivo results indicated that CES could reduce the arthritis score, paw swelling, and improve histopathological deterioration. The levels of inflammatory factors, matrix metalloproteinases, and proteins expressed in rat synovial tissue were suppressed after treatment with CES. These findings illustrate that CES is involved in the PI3K/AKT/mTOR/SREBP1/SCD-1/GPX4 axis–mediated ferroptosis and anti-inflammation, exerting its protective effects against the progression of RA.
{"title":"Ecdysteroid-enriched fraction of Cyathula officinalis suppresses synovial proliferation and inflammation to ameliorate RA by inhibiting the AKT/PI3K/mTOR signaling pathway","authors":"Yue-Hui Huang , Lu Qiu , Yi Peng , Rui Cai , Qing-Qing Xiao , Mei-Chen Li , Li-Jia Xu , Qiang Fu","doi":"10.1080/10286020.2025.2492357","DOIUrl":"10.1080/10286020.2025.2492357","url":null,"abstract":"<div><div>This study investigated the chemical compositions isolated from <em>Cyathula officinalis</em> (CES) and elucidated its anti-RA effects and potential mechanisms. <em>In vitro</em> results revealed that CES suppressed interleukin (IL)-1β-stimulated proliferation, migration, and invasion of MH7A cells in a concentration-dependent manner. <em>In vivo</em> results indicated that CES could reduce the arthritis score, paw swelling, and improve histopathological deterioration. The levels of inflammatory factors, matrix metalloproteinases, and proteins expressed in rat synovial tissue were suppressed after treatment with CES. These findings illustrate that CES is involved in the PI3K/AKT/mTOR/SREBP1/SCD-1/GPX4 axis–mediated ferroptosis and anti-inflammation, exerting its protective effects against the progression of RA.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"28 1","pages":"Pages 175-197"},"PeriodicalIF":1.3,"publicationDate":"2026-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-02DOI: 10.1080/10286020.2025.2482068
Yu-Gang Fu , Jun-Min Wang , Si-Min Gu , Chong Chen , Yan-Ping Wang , Yi-Yuan Zheng , Yong Li
Hepatic fibrosis, a precursor to chronic liver diseases, is linked to circadian rhythm disruptions. This study investigates the anti-fibrotic effects of saikosaponin D (SSd) from Bupleurum falcatum L. and its regulation of circadian genes. Transcriptomic and single-cell analyses revealed circadian gene dysregulation, particularly Period 2 (Per2), in liver fibrosis and hepatic stellate cells. SSd upregulated Per2 transcription via estrogen receptor 1 (Esr1), as confirmed by siRNA, real-time quantitative polymerase chain reaction, and Western blot analyses. In vivo, SSd alleviated fibrosis and hepatitis, increasing Esr1 but not Per2 protein levels. These findings suggest SSd exerts anti-fibrotic effects by modulating Esr1-mediated Per2 transcription.
{"title":"Saikosaponin D, a triterpene saponin from Bupleurum falcatum, restores circadian rhythm and attenuates hepatic fibrosis via Esr1-Per2 axis","authors":"Yu-Gang Fu , Jun-Min Wang , Si-Min Gu , Chong Chen , Yan-Ping Wang , Yi-Yuan Zheng , Yong Li","doi":"10.1080/10286020.2025.2482068","DOIUrl":"10.1080/10286020.2025.2482068","url":null,"abstract":"<div><div>Hepatic fibrosis, a precursor to chronic liver diseases, is linked to circadian rhythm disruptions. This study investigates the anti-fibrotic effects of saikosaponin D (SSd) from <em>Bupleurum falcatum L</em>. and its regulation of circadian genes. Transcriptomic and single-cell analyses revealed circadian gene dysregulation, particularly Period 2 (Per2), in liver fibrosis and hepatic stellate cells. SSd upregulated Per2 transcription via estrogen receptor 1 (Esr1), as confirmed by siRNA, real-time quantitative polymerase chain reaction, and Western blot analyses. <em>In vivo</em>, SSd alleviated fibrosis and hepatitis, increasing Esr1 but not Per2 protein levels. These findings suggest SSd exerts anti-fibrotic effects by modulating Esr1-mediated Per2 transcription.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"28 1","pages":"Pages 157-174"},"PeriodicalIF":1.3,"publicationDate":"2026-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-02DOI: 10.1080/10286020.2025.2488316
Teng-Teng Huang , Xiao-Ling Chen , Dai-Wen Chen , Bing Yu , Ping Zheng , Hui Yan , Jun He , Zhi-Qing Huang
This study aims to elucidate Lycium barbarum (LB)’s anti-fatigue mechanisms. Meta-analysis confirmed LB’s anti-fatigue capacity, while network pharmacology, molecular docking, and molecular dynamics simulations identified key targets (SRC, HSP90AA1, EGFR, PRKACA, MAPK1). Furthermore, validation experiments in C2C12 cells demonstrated that LB mitigates H2O2-induced reactive oxygen species (ROS) accumulation and restores cell viability. qPCR analysis further revealed that LB downregulates the mRNA expression of CAT, IL-6 and TNF-α, while modulating the expression of these target genes. In summary, our data confirm the anti-fatigue effects of LB and elucidate that LB exerts multi-component, multi-target, and multi-pathway mechanisms in combating fatigue.
{"title":"Integrated meta-analysis, network pharmacology, computational biology, and in vitro experimental verification to reveal the anti-fatigue mechanism of Lycium barbarum","authors":"Teng-Teng Huang , Xiao-Ling Chen , Dai-Wen Chen , Bing Yu , Ping Zheng , Hui Yan , Jun He , Zhi-Qing Huang","doi":"10.1080/10286020.2025.2488316","DOIUrl":"10.1080/10286020.2025.2488316","url":null,"abstract":"<div><div>This study aims to elucidate <em>Lycium barbarum</em> (LB)’s anti-fatigue mechanisms. Meta-analysis confirmed LB’s anti-fatigue capacity, while network pharmacology, molecular docking, and molecular dynamics simulations identified key targets (SRC, HSP90AA1, EGFR, PRKACA, MAPK1). Furthermore, validation experiments in C2C12 cells demonstrated that LB mitigates H<sub>2</sub>O<sub>2</sub>-induced reactive oxygen species (ROS) accumulation and restores cell viability. qPCR analysis further revealed that LB downregulates the mRNA expression of <em>CAT</em>, <em>IL-6</em> and <em>TNF-α</em>, while modulating the expression of these target genes. In summary, our data confirm the anti-fatigue effects of LB and elucidate that LB exerts multi-component, multi-target, and multi-pathway mechanisms in combating fatigue.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"28 1","pages":"Pages 128-141"},"PeriodicalIF":1.3,"publicationDate":"2026-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144009198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-02DOI: 10.1080/10286020.2025.2492351
En-Hui Zhang , Dan Liu , Yong Xiang
Three new polycyclic polyprenylated acylphloroglucinols, attenuatumines A-C (1–3), were ioslated from the 90% EtOH extract of the air dried aerial parts of Hypericum attenuatum. Structural elucidation of all the compounds was performed by spectral methods such as 1D and 2D (1H-1H COSY, HMQC, and HMBC) NMR spectroscopy. All the isolated compounds were evaluated for their antidepressant activity by inhibiting reuptake of tritiated serotonin ([3H]-5-HT) and noradrenalinet ([3H]-NE) in rat brain synaptosomes. Compounds 2 exhibited some antidepressant activities in the [3H]-5-HT mode.
{"title":"Polyprenylated acylphloroglucinols from Hypericum attenuatum and their antidepressant activities","authors":"En-Hui Zhang , Dan Liu , Yong Xiang","doi":"10.1080/10286020.2025.2492351","DOIUrl":"10.1080/10286020.2025.2492351","url":null,"abstract":"<div><div>Three new polycyclic polyprenylated acylphloroglucinols, attenuatumines A-C (<strong>1–3</strong>), were ioslated from the 90% EtOH extract of the air dried aerial parts of <em>Hypericum attenuatum</em>. Structural elucidation of all the compounds was performed by spectral methods such as 1D and 2D (<sup>1</sup>H-<sup>1</sup>H COSY, HMQC, and HMBC) NMR spectroscopy. All the isolated compounds were evaluated for their antidepressant activity by inhibiting reuptake of tritiated serotonin ([<sup>3</sup>H]-5-HT) and noradrenalinet ([<sup>3</sup>H]-NE) in rat brain synaptosomes. Compounds <strong>2</strong> exhibited some antidepressant activities in the [<sup>3</sup>H]-5-HT mode.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"28 1","pages":"Pages 34-40"},"PeriodicalIF":1.3,"publicationDate":"2026-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144019914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-02DOI: 10.1080/10286020.2025.2491611
Yan-Yuan Zhou , Ya-Zhou Li , Zhi-Qiang Liu , Xiao-Hui Qin , Ya-Qi Wu , Chao-Jie Chong , Liang Lyu , Cheng-Xue Pan
This study explored rhamnocitrin’s apoptotic effects on human nasopharyngeal carcinoma cell lines (CNE-2/C666-1) and underlying mechanisms. Following treatment with varying concentrations, cell proliferation, apoptosis, and protein expression were analyzed using MTT assay, Hoechst/Annexin V-FITC/PI staining, and western blot. Results showed rhamnocitrin inhibited cell proliferation, induced apoptosis, downregulated IGF-1R, Erk1/2, and Akt phosphorylation, and activated caspase 3, caspase 8, caspase 9, and Bax while inhibiting survivin, Bcl-2, and Mcl-1. In conclusion, rhamnocitrin induces apoptosis in nasopharyngeal carcinoma cells by inhibiting the IGF-1R signaling pathway and its downstream effectors Akt and Erk1/2.
{"title":"Rhamnocitrin induces apoptosis of human nasopharyngeal carcinoma by inhibiting IGF-1R signaling pathway in vitro","authors":"Yan-Yuan Zhou , Ya-Zhou Li , Zhi-Qiang Liu , Xiao-Hui Qin , Ya-Qi Wu , Chao-Jie Chong , Liang Lyu , Cheng-Xue Pan","doi":"10.1080/10286020.2025.2491611","DOIUrl":"10.1080/10286020.2025.2491611","url":null,"abstract":"<div><div>This study explored rhamnocitrin’s apoptotic effects on human nasopharyngeal carcinoma cell lines (CNE-2/C666-1) and underlying mechanisms. Following treatment with varying concentrations, cell proliferation, apoptosis, and protein expression were analyzed using MTT assay, Hoechst/Annexin V-FITC/PI staining, and western blot. Results showed rhamnocitrin inhibited cell proliferation, induced apoptosis, downregulated IGF-1R, Erk1/2, and Akt phosphorylation, and activated caspase 3, caspase 8, caspase 9, and Bax while inhibiting survivin, Bcl-2, and Mcl-1. In conclusion, rhamnocitrin induces apoptosis in nasopharyngeal carcinoma cells by inhibiting the IGF-1R signaling pathway and its downstream effectors Akt and Erk1/2.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"28 1","pages":"Pages 112-127"},"PeriodicalIF":1.3,"publicationDate":"2026-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143985177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-02DOI: 10.1080/10286020.2025.2490115
Qi-Guo Wu , Si-Meng Li , Ye-Qing Hu , Fu Cao , Yong-Li Wang , Gui-Xin Chou
Phytochemical analysis of Artemisia annua aerial parts revealed three novel lignan glycosides (arteannuoside A-B, annusesquilignanoside) and 18 known compounds (4-21), including spanning megastigmanes (4-13), coumarin (14), nitrogen-containing compound (15), phenylethanol glycoside (16), and phenolic compounds (17-21). Compounds (4, 6, 10, 12, 15-18) were first isolated from this species. Structural characterization employed NMR spectroscopy and literature comparison. The new compounds demonstrated concentration-dependent IL-6 inhibition in LPS-activated macrophages. At 100 μM, compounds 1 (68.75%), 2 (71.89%) and 3 (61.34%) showed strong activity, while at 50 μM yielded 33.45%, 39.37%, and 45.36% inhibition respectively.
{"title":"Chemical constituents from Artemisia annua with potential anti-inflammatory activities","authors":"Qi-Guo Wu , Si-Meng Li , Ye-Qing Hu , Fu Cao , Yong-Li Wang , Gui-Xin Chou","doi":"10.1080/10286020.2025.2490115","DOIUrl":"10.1080/10286020.2025.2490115","url":null,"abstract":"<div><div>Phytochemical analysis of <em>Artemisia annua</em> aerial parts revealed three novel lignan glycosides (arteannuoside A-B, annusesquilignanoside) and 18 known compounds (<strong>4</strong>-<strong>21</strong>), including spanning megastigmanes (<strong>4-13</strong>), coumarin (<strong>14</strong>), nitrogen-containing compound (<strong>15</strong>), phenylethanol glycoside (<strong>16</strong>), and phenolic compounds (<strong>17</strong>-<strong>21</strong>). Compounds (<strong>4, 6, 10, 12, 15-18)</strong> were first isolated from this species. Structural characterization employed NMR spectroscopy and literature comparison. The new compounds demonstrated concentration-dependent IL-6 inhibition in LPS-activated macrophages. At 100 μM, compounds <strong>1</strong> (68.75%), <strong>2</strong> (71.89%) and <strong>3</strong> (61.34%) showed strong activity, while at 50 μM yielded 33.45%, 39.37%, and 45.36% inhibition respectively.</div></div>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":"28 1","pages":"Pages 41-52"},"PeriodicalIF":1.3,"publicationDate":"2026-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144007539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-02DOI: 10.1080/10286020.2025.2603644
Xin-Yu Cai, Ji-Mei Liu, Jun-Gui Dai
Two new metabolites, 29-demethyl-3-ene-cycloastragenol (2) and 1α,12α-dihydroxy-cycloastragenone (3), along with six known compounds (4-9) were obtained from the microbial transformation of cycloastragenol (1) by Penicillium spinulosum AS3.149. The structures of these metabolites were determined by extensive spectroscopic (IR, UV, HRESIMS, 1D and 2D NMR) data analyses. Compound 2 features a 29-nor-triterpenic skeleton, possibly formed through sequential oxidation, decarboxylation, and dehydration reactions. Biological assays revealed that compound 6 exhibited significant cytotoxic activity against the K562 cell line with an IC50 value of 1.0 μM.
{"title":"Microbial transformation of cycloastragenol by <i>Penicillium spinulosum</i> AS3.149.","authors":"Xin-Yu Cai, Ji-Mei Liu, Jun-Gui Dai","doi":"10.1080/10286020.2025.2603644","DOIUrl":"https://doi.org/10.1080/10286020.2025.2603644","url":null,"abstract":"<p><p>Two new metabolites, 29-demethyl-3-ene-cycloastragenol (<b>2</b>) and 1<i>α</i>,12<i>α</i>-dihydroxy-cycloastragenone (<b>3</b>), along with six known compounds (<b>4</b>-<b>9</b>) were obtained from the microbial transformation of cycloastragenol (<b>1</b>) by <i>Penicillium spinulosum</i> AS3.149. The structures of these metabolites were determined by extensive spectroscopic (IR, UV, HRESIMS, 1D and 2D NMR) data analyses. Compound <b>2</b> features a 29-nor-triterpenic skeleton, possibly formed through sequential oxidation, decarboxylation, and dehydration reactions. Biological assays revealed that compound <b>6</b> exhibited significant cytotoxic activity against the K562 cell line with an IC<sub>50</sub> value of 1.0 μM.</p>","PeriodicalId":15180,"journal":{"name":"Journal of Asian Natural Products Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.3,"publicationDate":"2026-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145889282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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