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Salidroside attenuates sepsis-induced acute kidney injury by inhibiting ferroptosis 红景天苷通过抑制铁下垂减轻败血症引起的急性肾损伤。
IF 1.3 3区 医学 Q3 CHEMISTRY, APPLIED
Journal of Asian Natural Products Research
Pub Date : 2026-01-02 DOI: 10.1080/10286020.2025.2481291
Ling-Ling Zhen , Ming-Tong Hou , Sheng-Bao Wang
Salidroside is a traditional Chinese medicine with multiple pharmacological activities such as anti-inflammatory and antioxidant properties, while acute kidney injury (AKI) is a common sepsis-induced acute inflammatory response. Using transcriptomics combined with metabolomics, this study identifies arachidonic acid metabolism-associated ferroptosis as an important mechanism for salidroside to improve sepsis-induced AKI (SI-AKI).
红景天苷是一种具有抗炎、抗氧化等多种药理活性的中药，而急性肾损伤（AKI）是一种常见的脓毒症引起的急性炎症反应。本研究利用转录组学和代谢组学相结合的方法，发现花生四烯酸代谢相关的铁下垂是红景天苷改善败血症诱导AKI （SI-AKI）的重要机制。
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引用次数: 0
Design, synthesis, and mechanism study of novel natural-based isoquinolone derivatives as potential antifungal agents 新型天然异喹诺酮类抗真菌药物的设计、合成及作用机理研究。
IF 1.3 3区 医学 Q3 CHEMISTRY, APPLIED
Journal of Asian Natural Products Research
Pub Date : 2026-01-02 DOI: 10.1080/10286020.2025.2492353
Wei Chen , Tao Huang , Yan-Xi Jin , Si-Min Lei , Lu-Yao Wang , Yang Chen
A series of isoquinolone compounds Ia-Iq containing amide moiety were rationally designed and synthesized based-on isoquinolone alkaloids. Their structures were confirmed by 1H NMR,13C NMR and HRMS. Most of the title compounds showed medium to excellent antifungal activity in vitro at 50 mg/L. Especially, the EC50 of Im (13.155 mg/L) against P. piricola was slightly better than chlorothalonil (14.323 mg/L). The in vivo activity of Im against P. piricola on apples was comparable to chlorothalonil. Preliminary mechanistic exploration illustrated that Im strongly damage the mycelium morphology. Furthermore, molecular electrostatic potential and molecular docking analysis revealed that Im could interact with the residues of SDH via hydrogen bond.
以异喹诺酮类生物碱为基础，合理设计合成了一系列含酰胺基团的异喹诺酮类化合物Ia-Iq。它们的结构经1H NMR、13C NMR和HRMS确证。大多数标题化合物在50 mg/L的浓度下表现出中等至优异的抗真菌活性。其中，Im （13.155 mg/L）对piricola的EC50值略高于百菌清（14.323 mg/L）。Im对苹果番茄枯萎病的体内活性与百菌清相当。初步的机制探索表明，Im对菌丝形态有强烈的破坏作用。此外，分子静电势和分子对接分析表明，Im可以通过氢键与SDH残基相互作用。
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引用次数: 0
Iridoid glycosides from the leaves of Paederia foetida and their antinociceptive activities 黄连叶环烯醚萜苷类化合物及其抗伤活性研究。
IF 1.3 3区 医学 Q3 CHEMISTRY, APPLIED
Journal of Asian Natural Products Research
Pub Date : 2026-01-02 DOI: 10.1080/10286020.2025.2490108
Yu-Feng Chen , Wei Gong , Xue Sun
A chemical investigation on the leaves of Paederia Foetida resulted into the isolation of two new iridoid glycosides, paefoetines A and B (1 and 2). Structural elucidation of all the compounds was performed by spectral methods such as 1D and 2D (1H-1H COSY, HMQC, and HMBC) NMR spectroscopy. The two isolated iridoid glycosides were tested in vivo for their antinociceptive properties. As a result, 1 exhibited potent antinociceptive activity and its ED50 value (49.2 μmol/kg) was twofold less than those of the positive control drugs aspirin.
从小檗叶中分离到两种新的环烯醚萜苷，paefoetines A和B（1和2）。所有化合物的结构通过1D和2D (1H-1H COSY， HMQC和HMBC) NMR光谱方法进行了分析。对分离得到的两种环烯醚萜苷进行了体内抗伤性实验。结果表明，1具有较强的抗伤感受活性，其ED50值（49.2 μmol/kg）比阳性对照药物阿司匹林低2倍。
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引用次数: 0
Ecdysteroid-enriched fraction of Cyathula officinalis suppresses synovial proliferation and inflammation to ameliorate RA by inhibiting the AKT/PI3K/mTOR signaling pathway Cyathula officinalis富含表皮甾体激素的部位通过抑制AKT/PI3K/mTOR信号通路抑制滑膜增生和炎症，改善RA。
IF 1.3 3区 医学 Q3 CHEMISTRY, APPLIED
Journal of Asian Natural Products Research
Pub Date : 2026-01-02 DOI: 10.1080/10286020.2025.2492357
Yue-Hui Huang , Lu Qiu , Yi Peng , Rui Cai , Qing-Qing Xiao , Mei-Chen Li , Li-Jia Xu , Qiang Fu
This study investigated the chemical compositions isolated from Cyathula officinalis (CES) and elucidated its anti-RA effects and potential mechanisms. In vitro results revealed that CES suppressed interleukin (IL)-1β-stimulated proliferation, migration, and invasion of MH7A cells in a concentration-dependent manner. In vivo results indicated that CES could reduce the arthritis score, paw swelling, and improve histopathological deterioration. The levels of inflammatory factors, matrix metalloproteinases, and proteins expressed in rat synovial tissue were suppressed after treatment with CES. These findings illustrate that CES is involved in the PI3K/AKT/mTOR/SREBP1/SCD-1/GPX4 axis–mediated ferroptosis and anti-inflammation, exerting its protective effects against the progression of RA.
本研究对Cyathula officinalis （CES）的化学成分进行了研究，并对其抗类风湿性关节炎的作用及其可能的机制进行了初步探讨。体外实验结果显示，CES以浓度依赖性的方式抑制白细胞介素(IL)-1β刺激的MH7A细胞的增殖、迁移和侵袭。体内实验结果表明，CES可减轻关节炎评分，减轻足跖肿胀，改善组织病理恶化。大鼠滑膜组织炎症因子、基质金属蛋白酶和蛋白表达水平均受到抑制。这些研究结果表明，CES参与PI3K/AKT/mTOR/SREBP1/SCD-1/GPX4轴介导的铁下沉和抗炎，对RA的进展发挥保护作用。
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引用次数: 0
Saikosaponin D, a triterpene saponin from Bupleurum falcatum, restores circadian rhythm and attenuates hepatic fibrosis via Esr1-Per2 axis 柴胡皂苷D是一种来自柴胡的三萜皂苷，通过Esr1-Per2轴恢复昼夜节律并减轻肝纤维化。
IF 1.3 3区 医学 Q3 CHEMISTRY, APPLIED
Journal of Asian Natural Products Research
Pub Date : 2026-01-02 DOI: 10.1080/10286020.2025.2482068
Yu-Gang Fu , Jun-Min Wang , Si-Min Gu , Chong Chen , Yan-Ping Wang , Yi-Yuan Zheng , Yong Li
Hepatic fibrosis, a precursor to chronic liver diseases, is linked to circadian rhythm disruptions. This study investigates the anti-fibrotic effects of saikosaponin D (SSd) from Bupleurum falcatum L. and its regulation of circadian genes. Transcriptomic and single-cell analyses revealed circadian gene dysregulation, particularly Period 2 (Per2), in liver fibrosis and hepatic stellate cells. SSd upregulated Per2 transcription via estrogen receptor 1 (Esr1), as confirmed by siRNA, real-time quantitative polymerase chain reaction, and Western blot analyses. In vivo, SSd alleviated fibrosis and hepatitis, increasing Esr1 but not Per2 protein levels. These findings suggest SSd exerts anti-fibrotic effects by modulating Esr1-mediated Per2 transcription.
肝纤维化是慢性肝病的前兆，与昼夜节律紊乱有关。本研究调查了柴胡中的柴胡皂苷 D（SSd）的抗纤维化作用及其对昼夜节律基因的调控。转录组和单细胞分析表明，肝纤维化和肝星状细胞中的昼夜节律基因失调，尤其是周期2（Per2）。经 siRNA、实时定量聚合酶链反应和 Western 印迹分析证实，SSd 通过雌激素受体 1（Esr1）上调 Per2 的转录。在体内，SSd 能减轻肝纤维化和肝炎，提高 Esr1 蛋白水平，但不能提高 Per2 蛋白水平。这些发现表明 SSd 通过调节 Esr1 介导的 Per2 转录发挥抗纤维化作用。
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引用次数: 0
Integrated meta-analysis, network pharmacology, computational biology, and in vitro experimental verification to reveal the anti-fatigue mechanism of Lycium barbarum 综合meta分析、网络药理学、计算生物学、体外实验验证等方法，揭示枸杞抗疲劳作用机制。
IF 1.3 3区 医学 Q3 CHEMISTRY, APPLIED
Journal of Asian Natural Products Research
Pub Date : 2026-01-02 DOI: 10.1080/10286020.2025.2488316
Teng-Teng Huang , Xiao-Ling Chen , Dai-Wen Chen , Bing Yu , Ping Zheng , Hui Yan , Jun He , Zhi-Qing Huang
This study aims to elucidate Lycium barbarum (LB)’s anti-fatigue mechanisms. Meta-analysis confirmed LB’s anti-fatigue capacity, while network pharmacology, molecular docking, and molecular dynamics simulations identified key targets (SRC, HSP90AA1, EGFR, PRKACA, MAPK1). Furthermore, validation experiments in C2C12 cells demonstrated that LB mitigates H2O2-induced reactive oxygen species (ROS) accumulation and restores cell viability. qPCR analysis further revealed that LB downregulates the mRNA expression of CAT, IL-6 and TNF-α, while modulating the expression of these target genes. In summary, our data confirm the anti-fatigue effects of LB and elucidate that LB exerts multi-component, multi-target, and multi-pathway mechanisms in combating fatigue.
本研究旨在阐明枸杞（LB）的抗疲劳作用机制。meta分析证实了LB的抗疲劳能力，而网络药理学、分子对接和分子动力学模拟确定了关键靶点（SRC、HSP90AA1、EGFR、PRKACA、MAPK1）。此外，在C2C12细胞中的验证实验表明，LB减轻h2o2诱导的活性氧（ROS）积累，恢复细胞活力。qPCR分析进一步发现，LB下调CAT、IL-6和TNF-α mRNA的表达，同时调节这些靶基因的表达。综上所述，我们的数据证实了LB的抗疲劳作用，并阐明了LB在抗疲劳中发挥多组分、多靶点和多途径的机制。
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引用次数: 0
Polyprenylated acylphloroglucinols from Hypericum attenuatum and their antidepressant activities 金丝桃中聚丙烯化酰基间苯三酚及其抗抑郁活性。
IF 1.3 3区 医学 Q3 CHEMISTRY, APPLIED
Journal of Asian Natural Products Research
Pub Date : 2026-01-02 DOI: 10.1080/10286020.2025.2492351
En-Hui Zhang , Dan Liu , Yong Xiang
Three new polycyclic polyprenylated acylphloroglucinols, attenuatumines A-C (1–3), were ioslated from the 90% EtOH extract of the air dried aerial parts of Hypericum attenuatum. Structural elucidation of all the compounds was performed by spectral methods such as 1D and 2D (1H-1H COSY, HMQC, and HMBC) NMR spectroscopy. All the isolated compounds were evaluated for their antidepressant activity by inhibiting reuptake of tritiated serotonin ([3H]-5-HT) and noradrenalinet ([3H]-NE) in rat brain synaptosomes. Compounds 2 exhibited some antidepressant activities in the [3H]-5-HT mode.
从垂穗金丝桃风干部分的90% EtOH提取液中分离出3种新的多环聚丙烯化酰基间苯三酚：垂穗金丝桃A-C（1-3）。所有化合物的结构通过1D和2D (1H-1H COSY， HMQC和HMBC) NMR光谱方法进行了分析。通过抑制大鼠脑突触体中5-羟色胺（[3H]-5-HT）和去甲肾上腺素（[3H]-NE）的再摄取来评价各分离化合物的抗抑郁活性。化合物2在[3H]-5-HT模式下表现出一定的抗抑郁活性。
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引用次数: 0
Microbial transformation of cycloastragenol by Penicillium spinulosum AS3.149. 棘青霉AS3.149转化环黄芪醇的研究
IF 1.3 3区 医学 Q3 CHEMISTRY, APPLIED
Journal of Asian Natural Products Research
Pub Date : 2026-01-02 DOI: 10.1080/10286020.2025.2603644
Xin-Yu Cai, Ji-Mei Liu, Jun-Gui Dai

Two new metabolites, 29-demethyl-3-ene-cycloastragenol (2) and 1α,12α-dihydroxy-cycloastragenone (3), along with six known compounds (4-9) were obtained from the microbial transformation of cycloastragenol (1) by Penicillium spinulosum AS3.149. The structures of these metabolites were determined by extensive spectroscopic (IR, UV, HRESIMS, 1D and 2D NMR) data analyses. Compound 2 features a 29-nor-triterpenic skeleton, possibly formed through sequential oxidation, decarboxylation, and dehydration reactions. Biological assays revealed that compound 6 exhibited significant cytotoxic activity against the K562 cell line with an IC50 value of 1.0 μM.

通过spinulosum青霉AS3.149对环黄芪醇(1)的微生物转化，获得了2个新的代谢物29-二甲基-3-烯-环黄芪醇(2)和1α，12α-二羟基-环黄芪酮(3)，以及6个已知化合物（4-9）。这些代谢物的结构通过广泛的光谱（IR， UV, hresms， 1D和2D NMR）数据分析确定。化合物2具有29-正三萜骨架，可能通过连续氧化、脱羧和脱水反应形成。生物实验表明，化合物6对K562细胞株具有明显的细胞毒活性，IC50值为1.0 μM。
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引用次数: 0
Panax ginseng nanoemulsion: a promising pre-clinical modality for ameliorating male infertility via manipulation of PI3K/AKT/mTOR signaling pathway. 人参纳米乳：通过操纵PI3K/AKT/mTOR信号通路改善男性不育症的一种有前途的临床前模式
IF 1.3 3区 医学 Q3 CHEMISTRY, APPLIED
Journal of Asian Natural Products Research
Pub Date : 2026-01-02 DOI: 10.1080/10286020.2025.2599283
Basma I El-Shimi, Rafat M Mohareb, Hanaa H Ahmed, Khaled F Mahmoud, Demiana H Hanna, Rehab S Abohashem

The study investigates Panax ginseng nanoemulsion role in counteracting male infertility in rats. Nanoemulsion was prepared by oil in water method, then it was characterized by transmission electron microscope (TEM), Zeta sizer, Fourier transform infrared spectroscopy (FTIR), and thermogravimetric analysis (TGA). The serum total testosterone, free testosterone, Luteinizing Hormone (LH), and Follicle-Stimulating Hormone (FSH) were measured. Phosphatidylinositol 3-kinase (PI3K), Protein kinase B (AKT), mammalian target of rapamycin (mTOR), E-cadherin (E-cad), and connexin 43 (Cx43) expression were analyzed. A histological examination of testes was also carried out. Nanoemulsion exhibited a spherical morphology, with diameter from 5.98 to 51.80 nm. Additionally, Zeta sizer determined size distribution by number from 97.74 to 147.4 nm. Zeta potential revealed negatively charged surface. FTIR showed common active groups. Nanoemulsions demonstrated thermal stability up to 207 °C. Biological experiments indicated that adverse effects of bisphenol A (BPA) were counteracted by Panax ginseng in either nanoemulsion or free form and vitamin E (Vit.E). Panax ginseng nanoemulsion recovers male infertility in rats. These outcomes may have a significant impact on developing a new therapeutic entity to treat male infertile patients.

研究了人参纳米乳对大鼠雄性不育的拮抗作用。采用水包油法制备纳米乳，并采用透射电镜（TEM）、Zeta浆料机、傅里叶红外光谱（FTIR）和热重分析（TGA）对其进行表征。测定血清总睾酮、游离睾酮、促黄体生成素（LH）、促卵泡激素（FSH）水平。分析磷脂酰肌醇3-激酶（PI3K）、蛋白激酶B （AKT）、哺乳动物雷帕霉素靶蛋白（mTOR）、e -钙粘蛋白（E-cad）和连接蛋白43 （Cx43）的表达。对睾丸进行组织学检查。纳米乳呈球形，粒径在5.98 ~ 51.80 nm之间。此外，Zeta浆料机确定了97.74 ~ 147.4 nm范围内的粒径分布。Zeta电位显示带负电荷的表面。FTIR显示有共同的活性组。纳米乳液表现出高达207℃的热稳定性。生物学实验表明，纳米乳或游离形式的人参和维生素E均能抵消双酚A （BPA）的不良影响。人参纳米乳对雄性不育大鼠的恢复作用。这些结果可能对开发一种治疗男性不育症的新疗法产生重大影响。
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引用次数: 0
Rhamnocitrin induces apoptosis of human nasopharyngeal carcinoma by inhibiting IGF-1R signaling pathway in vitro 鼠李柠檬素通过抑制IGF-1R信号通路诱导鼻咽癌细胞凋亡。
IF 1.3 3区 医学 Q3 CHEMISTRY, APPLIED
Journal of Asian Natural Products Research
Pub Date : 2026-01-02 DOI: 10.1080/10286020.2025.2491611
Yan-Yuan Zhou , Ya-Zhou Li , Zhi-Qiang Liu , Xiao-Hui Qin , Ya-Qi Wu , Chao-Jie Chong , Liang Lyu , Cheng-Xue Pan
This study explored rhamnocitrin’s apoptotic effects on human nasopharyngeal carcinoma cell lines (CNE-2/C666-1) and underlying mechanisms. Following treatment with varying concentrations, cell proliferation, apoptosis, and protein expression were analyzed using MTT assay, Hoechst/Annexin V-FITC/PI staining, and western blot. Results showed rhamnocitrin inhibited cell proliferation, induced apoptosis, downregulated IGF-1R, Erk1/2, and Akt phosphorylation, and activated caspase 3, caspase 8, caspase 9, and Bax while inhibiting survivin, Bcl-2, and Mcl-1. In conclusion, rhamnocitrin induces apoptosis in nasopharyngeal carcinoma cells by inhibiting the IGF-1R signaling pathway and its downstream effectors Akt and Erk1/2.
本研究探讨鼠李柠檬素对人鼻咽癌细胞株（CNE-2/C666-1）凋亡的影响及其机制。不同浓度处理后，采用MTT法、Hoechst/Annexin V-FITC/PI染色和western blot分析细胞增殖、凋亡和蛋白表达。结果表明，鼠李柑苷抑制细胞增殖，诱导细胞凋亡，下调IGF-1R、Erk1/2和Akt磷酸化，激活caspase 3、caspase 8、caspase 9和Bax，抑制survivin、Bcl-2和Mcl-1。综上所述，鼠李柑苷通过抑制IGF-1R信号通路及其下游效应物Akt和Erk1/2诱导鼻咽癌细胞凋亡。
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引用次数: 0
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