Pub Date : 2011-09-01DOI: 10.4028/www.scientific.net/JBBTE.11.21
K. Subramani, R. Mathew, H. Hosseinkhani, M. Hosseinkhani
This manuscript discusses peri-implantitis around dental implants and the current methodologies of surgical and non-surgical approaches towards treating peri-implantitis. Mechanical, chemical cleansing and reactivation of infected implant surface along with recent advances like the use of Laser and Photodynamic therapy (PDT) have also been reviewed in this literature. Bone regenerative treatment methods for the treatment of peri-implantitis using non-resorbable membranes (Guided Bone Regeneration), autogenous bone grafts and bone substitute materials with recombinant human bone morphogenetic protein-2 (rhBMP-2) and other growth factors have also been reviewed in this manuscript.
本文讨论了牙种植体周围的种植体周围炎，以及目前治疗种植体周围炎的手术和非手术方法。机械、化学清洗和重新激活感染种植体表面以及最近的进展，如激光和光动力治疗(PDT)的使用也在本文献中进行了综述。本文还综述了利用不可吸收膜(Guided Bone Regeneration)、自体骨移植物和含重组人骨形态发生蛋白-2 (rhBMP-2)等生长因子的骨替代材料治疗种植体周围炎的骨再生治疗方法。
{"title":"Bone Regeneration around Dental Implants as a Treatment for Peri-Implantitis: A Review of the Literature","authors":"K. Subramani, R. Mathew, H. Hosseinkhani, M. Hosseinkhani","doi":"10.4028/www.scientific.net/JBBTE.11.21","DOIUrl":"https://doi.org/10.4028/www.scientific.net/JBBTE.11.21","url":null,"abstract":"This manuscript discusses peri-implantitis around dental implants and the current methodologies of surgical and non-surgical approaches towards treating peri-implantitis. Mechanical, chemical cleansing and reactivation of infected implant surface along with recent advances like the use of Laser and Photodynamic therapy (PDT) have also been reviewed in this literature. Bone regenerative treatment methods for the treatment of peri-implantitis using non-resorbable membranes (Guided Bone Regeneration), autogenous bone grafts and bone substitute materials with recombinant human bone morphogenetic protein-2 (rhBMP-2) and other growth factors have also been reviewed in this manuscript.","PeriodicalId":15198,"journal":{"name":"Journal of Biomimetics, Biomaterials and Tissue Engineering","volume":"243 1","pages":"21 - 33"},"PeriodicalIF":0.0,"publicationDate":"2011-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77179370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2011-09-01DOI: 10.4028/www.scientific.net/JBBTE.11.93
A. Chen, C. Zhao, Shi-Bin Wang, Yuangang Liu
SiO2-hemoglobin-poly(L-lactide) (SiO2-Hb-PLLA) microspheres were prepared in a process of solution-enhanced dispersion by supercritical CO2 (SEDS). SiO2 nanoparticles were loaded with Hb by adsorption firstly and then the Hb-SiO2 nanoparticles were further coated with PLLA by the SEDS process. The resulted microcapsules were characterized by scanning electron microscope (SEM), laser diffraction particle size analyser and Fourier transform infrared spectrometer (FTIR). The drug release profiles were also determined. The Hb-SiO2-PLLA microspheres have a narrow particle size distribution (PDI 0.189) with a mean particle size of 897nm and a drug loading of 7.1%. After coating with PLLA, the drug release from SiO2-Hb-PLLA showed a sustained process mainly in zero-order kinetics; only 3.7% drug was released in the first 24 hours, versus 51.9% for those without coating, which revealed that the coating of PLLA significantly retarded the drug release. The results also indicate that the SEDS process is a typical physical process to produce protein-loaded polymer microspheres without changing the molecular structure of proteins, which is potential in the application of designing proteins drug delivery system.
{"title":"Preparation of Protein-Loaded Poly(L-Lactide) Microspheres by Solution-Enhanced Dispersion by Supercritical CO2","authors":"A. Chen, C. Zhao, Shi-Bin Wang, Yuangang Liu","doi":"10.4028/www.scientific.net/JBBTE.11.93","DOIUrl":"https://doi.org/10.4028/www.scientific.net/JBBTE.11.93","url":null,"abstract":"SiO2-hemoglobin-poly(L-lactide) (SiO2-Hb-PLLA) microspheres were prepared in a process of solution-enhanced dispersion by supercritical CO2 (SEDS). SiO2 nanoparticles were loaded with Hb by adsorption firstly and then the Hb-SiO2 nanoparticles were further coated with PLLA by the SEDS process. The resulted microcapsules were characterized by scanning electron microscope (SEM), laser diffraction particle size analyser and Fourier transform infrared spectrometer (FTIR). The drug release profiles were also determined. The Hb-SiO2-PLLA microspheres have a narrow particle size distribution (PDI 0.189) with a mean particle size of 897nm and a drug loading of 7.1%. After coating with PLLA, the drug release from SiO2-Hb-PLLA showed a sustained process mainly in zero-order kinetics; only 3.7% drug was released in the first 24 hours, versus 51.9% for those without coating, which revealed that the coating of PLLA significantly retarded the drug release. The results also indicate that the SEDS process is a typical physical process to produce protein-loaded polymer microspheres without changing the molecular structure of proteins, which is potential in the application of designing proteins drug delivery system.","PeriodicalId":15198,"journal":{"name":"Journal of Biomimetics, Biomaterials and Tissue Engineering","volume":"257 1","pages":"100 - 93"},"PeriodicalIF":0.0,"publicationDate":"2011-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78853021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2011-09-01DOI: 10.4028/www.scientific.net/JBBTE.11.35
M. Branham, T. Govender, E. Ross
The objectives in this study were to compare the removal of 2-M via different dialyzers (high- and low flux) under equilibrium or sink conditions, wherein there was highly selective antibody-based facilitated transport into a small volume dialysate reservoir. Using an in vitro haemodialysis model we perfused high-flux polymethylmethacrylate (PMMA), high-flux cellulose diacetate (CDA), and a low-flux polysulfone (PSF) membranes with known amounts of 2-M through the intracapillary space. Anti-2-M antibodies added to the extracapillary space were shown to create sink conditions across the membrane when its pore size is sufficiently large for diffusion and if 2-M is not strongly adsorbed to the membrane surface. Our results indicate that 2-M (~12kDa) does not penetrate low-flux dialyzers and that its adsorption to intracapillary PSF surfaces does not substantially affect clearance. 2-M strongly adsorbed to high-flux PMMA dialyzers (ko = 0.0271+0.002 min-1), but without significant clearance enhancement due to circulating antibodies. A significant clearance enhancement (101.2%+24.89) for 2-M due to immunoextraction was observed in the high-flux cellulose acetate dialyzers, but without passive adsorption to the surface. These studies demonstrate the utility of in vitro haemodialysis experiments to elucidate midsize molecule clearance in dialysis membranes under controlled conditions. The use of anti-2-M antibodies as dialysate additives might be feasible in the removal of 2-M from whole blood, highlighting the advantages of selective antibody-based extraction of disease-causing toxins into potentially simple extracorporeal devices with small volume receiver compartments.
{"title":"Beta-2 Microglobulin Removal by Immunoextraction and Passive Adsorption in High-Flux Dialyzers","authors":"M. Branham, T. Govender, E. Ross","doi":"10.4028/www.scientific.net/JBBTE.11.35","DOIUrl":"https://doi.org/10.4028/www.scientific.net/JBBTE.11.35","url":null,"abstract":"The objectives in this study were to compare the removal of 2-M via different dialyzers (high- and low flux) under equilibrium or sink conditions, wherein there was highly selective antibody-based facilitated transport into a small volume dialysate reservoir. Using an in vitro haemodialysis model we perfused high-flux polymethylmethacrylate (PMMA), high-flux cellulose diacetate (CDA), and a low-flux polysulfone (PSF) membranes with known amounts of 2-M through the intracapillary space. Anti-2-M antibodies added to the extracapillary space were shown to create sink conditions across the membrane when its pore size is sufficiently large for diffusion and if 2-M is not strongly adsorbed to the membrane surface. Our results indicate that 2-M (~12kDa) does not penetrate low-flux dialyzers and that its adsorption to intracapillary PSF surfaces does not substantially affect clearance. 2-M strongly adsorbed to high-flux PMMA dialyzers (ko = 0.0271+0.002 min-1), but without significant clearance enhancement due to circulating antibodies. A significant clearance enhancement (101.2%+24.89) for 2-M due to immunoextraction was observed in the high-flux cellulose acetate dialyzers, but without passive adsorption to the surface. These studies demonstrate the utility of in vitro haemodialysis experiments to elucidate midsize molecule clearance in dialysis membranes under controlled conditions. The use of anti-2-M antibodies as dialysate additives might be feasible in the removal of 2-M from whole blood, highlighting the advantages of selective antibody-based extraction of disease-causing toxins into potentially simple extracorporeal devices with small volume receiver compartments.","PeriodicalId":15198,"journal":{"name":"Journal of Biomimetics, Biomaterials and Tissue Engineering","volume":"57 1","pages":"35 - 44"},"PeriodicalIF":0.0,"publicationDate":"2011-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81543036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2011-09-01DOI: 10.4028/www.scientific.net/JBBTE.11.67
M. Buonsanti, A. Pontari
A new stress function modelling the fails in biological tissue is here proposed. Under the assumption that the cell membrane may be modelled as neo-Hookean materials, we develop the problem in the framework of non-linear elasticity. We attempt to model the ice nucleation phenomenon when freezing and thawing occurs in cellular cryo-preservation. The ice seed generated surface can be either soft or wrinkled and, when the latter emerges a punch contact against the cell membrane takes place. Restricting our attention on opportune mono-dimensional sub-set, we extend the multiple critical points theorem at our model. We find a particular solution in agreement to the classical fracture models besides a response function in accordance to the stress and strain field distribution in biological materials.
{"title":"A Theoretical Model to Fracture in Cell Membrane","authors":"M. Buonsanti, A. Pontari","doi":"10.4028/www.scientific.net/JBBTE.11.67","DOIUrl":"https://doi.org/10.4028/www.scientific.net/JBBTE.11.67","url":null,"abstract":"A new stress function modelling the fails in biological tissue is here proposed. Under the assumption that the cell membrane may be modelled as neo-Hookean materials, we develop the problem in the framework of non-linear elasticity. We attempt to model the ice nucleation phenomenon when freezing and thawing occurs in cellular cryo-preservation. The ice seed generated surface can be either soft or wrinkled and, when the latter emerges a punch contact against the cell membrane takes place. Restricting our attention on opportune mono-dimensional sub-set, we extend the multiple critical points theorem at our model. We find a particular solution in agreement to the classical fracture models besides a response function in accordance to the stress and strain field distribution in biological materials.","PeriodicalId":15198,"journal":{"name":"Journal of Biomimetics, Biomaterials and Tissue Engineering","volume":"8 1","pages":"67 - 71"},"PeriodicalIF":0.0,"publicationDate":"2011-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87933077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2011-09-01DOI: 10.4028/www.scientific.net/JBBTE.11.1
S. S. Pradhan, A. Sarkar
Pearl is a bio-originated valuable natural gem and it is also cultivated or harvested for jewellery. In this paper, the material aspects of pearl have been investigated experimentally and it has been found that it has a very high static dielectric constant ~ 105. The functional nature of the material is also established in this work. The beautiful lustre of natural pearl is explained by nano-optics and the layered structure of the material. The origin of super-dielectric nature of pearl has been explained by lightning rod effect (LRE) that causes ultra-high polarization of the dielectric background. The LRE is due to the presence of very small sized nano-particles in the natural pearl. Its electrical conductivity is mostly ionic, only less than 10% of the total conductivity is electronic. The scope of tailoring of its electro-activity has been probed.
{"title":"Pearl – A Nano-Composite & Natural Super Dielectric","authors":"S. S. Pradhan, A. Sarkar","doi":"10.4028/www.scientific.net/JBBTE.11.1","DOIUrl":"https://doi.org/10.4028/www.scientific.net/JBBTE.11.1","url":null,"abstract":"Pearl is a bio-originated valuable natural gem and it is also cultivated or harvested for jewellery. In this paper, the material aspects of pearl have been investigated experimentally and it has been found that it has a very high static dielectric constant ~ 105. The functional nature of the material is also established in this work. The beautiful lustre of natural pearl is explained by nano-optics and the layered structure of the material. The origin of super-dielectric nature of pearl has been explained by lightning rod effect (LRE) that causes ultra-high polarization of the dielectric background. The LRE is due to the presence of very small sized nano-particles in the natural pearl. Its electrical conductivity is mostly ionic, only less than 10% of the total conductivity is electronic. The scope of tailoring of its electro-activity has been probed.","PeriodicalId":15198,"journal":{"name":"Journal of Biomimetics, Biomaterials and Tissue Engineering","volume":"72 1","pages":"1 - 12"},"PeriodicalIF":0.0,"publicationDate":"2011-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79698819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2011-05-01DOI: 10.4028/www.scientific.net/JBBTE.10.25
M. Malik, Tiejia Shi, Zirong Tang
A dielectrophoretic approach with latest developed three-dimensional (3-D) carbon micro-electro-mechanical system (C-MEMS) has been extended as a potential route with idyllic solution to recommend a low-cost, biocompatible and high throughput manipulation and positioning for bio-particles as compared to 2D-planar microelectrodes. Presented in this paper is a novel platform for modelling and simulation of C-MEMS microfabrication process for dielectrophoresis (DEP) force based on various 3-D offset-microelectrode configurations. Numerical solutions are employed to investigate the upshots of multi-designed microelectrodes, applied voltage, electrode edge-to-edge gap and geometric size of microelectrodes on the electric field intensity gradient, induced by an AC voltage for the deployment of broad categories of bioparticles creation, utilization and their manipulation (separation, concentration, transportation and focusing). Sharp edge electrodes are the principle focus of this paper for DEP manipulation that is more convenient to enhance the electric field intensity distribution. The results show that square column electrodes configuration comparatively create large gradient magnitude in electric field intensity as compared to all other configurations. It is also observed that electric field extends drastically with increases in microelectrode height. These findings are consistent with literature experimental reports and will provide vital strategy for optimal design of DEP devices with 3-D C-MEMS.
{"title":"Trapping and Manipulation of Bioparticles by a 3-D Optimal Multiple-Designed Offset Carbon-Microelectrode Array in C-MEMS Fabrication","authors":"M. Malik, Tiejia Shi, Zirong Tang","doi":"10.4028/www.scientific.net/JBBTE.10.25","DOIUrl":"https://doi.org/10.4028/www.scientific.net/JBBTE.10.25","url":null,"abstract":"A dielectrophoretic approach with latest developed three-dimensional (3-D) carbon micro-electro-mechanical system (C-MEMS) has been extended as a potential route with idyllic solution to recommend a low-cost, biocompatible and high throughput manipulation and positioning for bio-particles as compared to 2D-planar microelectrodes. Presented in this paper is a novel platform for modelling and simulation of C-MEMS microfabrication process for dielectrophoresis (DEP) force based on various 3-D offset-microelectrode configurations. Numerical solutions are employed to investigate the upshots of multi-designed microelectrodes, applied voltage, electrode edge-to-edge gap and geometric size of microelectrodes on the electric field intensity gradient, induced by an AC voltage for the deployment of broad categories of bioparticles creation, utilization and their manipulation (separation, concentration, transportation and focusing). Sharp edge electrodes are the principle focus of this paper for DEP manipulation that is more convenient to enhance the electric field intensity distribution. The results show that square column electrodes configuration comparatively create large gradient magnitude in electric field intensity as compared to all other configurations. It is also observed that electric field extends drastically with increases in microelectrode height. These findings are consistent with literature experimental reports and will provide vital strategy for optimal design of DEP devices with 3-D C-MEMS.","PeriodicalId":15198,"journal":{"name":"Journal of Biomimetics, Biomaterials and Tissue Engineering","volume":"54 1","pages":"25 - 42"},"PeriodicalIF":0.0,"publicationDate":"2011-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79037226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2011-05-01DOI: 10.4028/www.scientific.net/JBBTE.10.55
Y. Chen, T. Xi, Yufei Zheng, Liangyu Zhou, Y. Wan
Nano-bacterial cellulose (nBC), secreted by Acetobacter xylinum, is expected to have potential applications in tissue engineering. In this paper, the in-vitro degradation performance and the corresponding mechanism of nBC immersed in phosphate buffer solution (PBS) for different time periods was investigated. The pH value variation of solution, material degradation, and the swelling and structural changes of nBC was analysed successively. The results indicate that water molecules attack the exposed nBC fibrils, weakening the bonding strength of inter- and intra-molecular chains and disconnecting partial C-O-C bonds. The disconnection of C-O-C bonds is considered the primary reason for the degradation of nBC large molecular chains after nBC is immersed in PBS. The present work is instructive for controlling the in-vivo degradation performance of nBC acting as bone tissue engineered scaffold materials.
{"title":"In Vitro Structural Changes of Nano-Bacterial Cellulose Immersed in Phosphate Buffer Solution","authors":"Y. Chen, T. Xi, Yufei Zheng, Liangyu Zhou, Y. Wan","doi":"10.4028/www.scientific.net/JBBTE.10.55","DOIUrl":"https://doi.org/10.4028/www.scientific.net/JBBTE.10.55","url":null,"abstract":"Nano-bacterial cellulose (nBC), secreted by Acetobacter xylinum, is expected to have potential applications in tissue engineering. In this paper, the in-vitro degradation performance and the corresponding mechanism of nBC immersed in phosphate buffer solution (PBS) for different time periods was investigated. The pH value variation of solution, material degradation, and the swelling and structural changes of nBC was analysed successively. The results indicate that water molecules attack the exposed nBC fibrils, weakening the bonding strength of inter- and intra-molecular chains and disconnecting partial C-O-C bonds. The disconnection of C-O-C bonds is considered the primary reason for the degradation of nBC large molecular chains after nBC is immersed in PBS. The present work is instructive for controlling the in-vivo degradation performance of nBC acting as bone tissue engineered scaffold materials.","PeriodicalId":15198,"journal":{"name":"Journal of Biomimetics, Biomaterials and Tissue Engineering","volume":"65 1","pages":"55 - 66"},"PeriodicalIF":0.0,"publicationDate":"2011-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74285373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2011-05-01DOI: 10.4028/www.scientific.net/JBBTE.10.1
Qiang Wang, Zhuang Yu, L. Yu
Biofouling on underwater engineered structures, especially on ship hulls, results in increased operational and maintenance costs. Fouling is not only of an ecological interest, but it is also important from applied and commercial perspectives. With the development of society, widely used Tributyltin compounds (TBT) for biofouling control have been prohibited worldwide at the end of 2008. The need to develop new environment friendly antifouling agents has been highlighted. Herein we report on the synthesis and characterization of a novel cross-linkable copolymer containing a HMBA side chain. The paper is mainly focused on the synthesis of novel resin and its antifouling performance. Apart from use of acrylate monomer, the two other important monomers γ-methacryloxypropyltrimethoxysilane (HD-70) and N-(4-Hydroxy-3-Methoxy-Benzyl) acrylanine (HMBA) were selected to construct low surface energy materials. Finally, the antifouling properties of resins were carried through by the colonization of benthic diatoms (Nitzschia flosterium) and ocean plates of an offshore platform. Experimental results indicated the novel resins containing a HMBA side chain possessing better antifouling properties than a standard polydimethyl siloxane (PDMS) coating in the Qingdao ocean.
{"title":"Anti-Biofouling of a Novel Cross-Linked Copolymer Containing a HMBA Side Chain","authors":"Qiang Wang, Zhuang Yu, L. Yu","doi":"10.4028/www.scientific.net/JBBTE.10.1","DOIUrl":"https://doi.org/10.4028/www.scientific.net/JBBTE.10.1","url":null,"abstract":"Biofouling on underwater engineered structures, especially on ship hulls, results in increased operational and maintenance costs. Fouling is not only of an ecological interest, but it is also important from applied and commercial perspectives. With the development of society, widely used Tributyltin compounds (TBT) for biofouling control have been prohibited worldwide at the end of 2008. The need to develop new environment friendly antifouling agents has been highlighted. Herein we report on the synthesis and characterization of a novel cross-linkable copolymer containing a HMBA side chain. The paper is mainly focused on the synthesis of novel resin and its antifouling performance. Apart from use of acrylate monomer, the two other important monomers γ-methacryloxypropyltrimethoxysilane (HD-70) and N-(4-Hydroxy-3-Methoxy-Benzyl) acrylanine (HMBA) were selected to construct low surface energy materials. Finally, the antifouling properties of resins were carried through by the colonization of benthic diatoms (Nitzschia flosterium) and ocean plates of an offshore platform. Experimental results indicated the novel resins containing a HMBA side chain possessing better antifouling properties than a standard polydimethyl siloxane (PDMS) coating in the Qingdao ocean.","PeriodicalId":15198,"journal":{"name":"Journal of Biomimetics, Biomaterials and Tissue Engineering","volume":"46 1","pages":"1 - 5"},"PeriodicalIF":0.0,"publicationDate":"2011-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87736282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2011-05-01DOI: 10.4028/www.scientific.net/JBBTE.10.17
S. R. Shah
In this present study a two-phase model for the influence of aspirin on peripheral layer viscosity for physiological characteristics of blood flow through stenosed blood vessels using Casson’s fluid model has been obtained. Flow of blood with axially non-symmetric but radially symmetric stenosis geometry is considered. The non-linear pressure equations have been solved with help of boundary conditions and the results are displayed graphically for different flow characteristics. It was found that the resistance to flow decreases as stenosis shape parameter increases whereas the resistance to flow increases with increasing values of stenosis length, stenosis size and peripheral layer viscosity. The effects of stenosis severity and wall shear stress are discussed in the present computational analysis. Comparisons between the measured and computed peripheral layer viscosity profiles are favourable to the solutions. As a result it can be concluded that a regular dose of Asprin decreases the blood viscosity by diluting the blood of diabetic patients which ultimately decreases the blood pressure. For the validation of the numerical model, the computation results are compared with the experimental data and results from published literature.
{"title":"Clinical Significance of Aspirin on Blood Flow through Stenotic Blood Vessels","authors":"S. R. Shah","doi":"10.4028/www.scientific.net/JBBTE.10.17","DOIUrl":"https://doi.org/10.4028/www.scientific.net/JBBTE.10.17","url":null,"abstract":"In this present study a two-phase model for the influence of aspirin on peripheral layer viscosity for physiological characteristics of blood flow through stenosed blood vessels using Casson’s fluid model has been obtained. Flow of blood with axially non-symmetric but radially symmetric stenosis geometry is considered. The non-linear pressure equations have been solved with help of boundary conditions and the results are displayed graphically for different flow characteristics. It was found that the resistance to flow decreases as stenosis shape parameter increases whereas the resistance to flow increases with increasing values of stenosis length, stenosis size and peripheral layer viscosity. The effects of stenosis severity and wall shear stress are discussed in the present computational analysis. Comparisons between the measured and computed peripheral layer viscosity profiles are favourable to the solutions. As a result it can be concluded that a regular dose of Asprin decreases the blood viscosity by diluting the blood of diabetic patients which ultimately decreases the blood pressure. For the validation of the numerical model, the computation results are compared with the experimental data and results from published literature.","PeriodicalId":15198,"journal":{"name":"Journal of Biomimetics, Biomaterials and Tissue Engineering","volume":"25 1","pages":"17 - 24"},"PeriodicalIF":0.0,"publicationDate":"2011-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88569953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2011-05-01DOI: 10.4028/WWW.SCIENTIFIC.NET/JBBTE.10.75
C. Mahapatra, K. Pramanik
Removed at authors request
应作者要求删除
{"title":"Perfusion Bioreactor Development for Functional Cartilage Implant: A Technical Note","authors":"C. Mahapatra, K. Pramanik","doi":"10.4028/WWW.SCIENTIFIC.NET/JBBTE.10.75","DOIUrl":"https://doi.org/10.4028/WWW.SCIENTIFIC.NET/JBBTE.10.75","url":null,"abstract":"Removed at authors request","PeriodicalId":15198,"journal":{"name":"Journal of Biomimetics, Biomaterials and Tissue Engineering","volume":"6 1","pages":"75 - 79"},"PeriodicalIF":0.0,"publicationDate":"2011-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83179453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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