Pub Date : 2020-01-20DOI: 10.3760/CMA.J.ISSN.1008-1372.2020.01.047
Dawei Qin
Neonatal neutropenia is classified into early-onset and late-onset neutropenia. Causes of neutropenia include decreased production, increased destruction, margination in the microvascular endothelium, sequestration in the spleen, or a combination of mechanisms. Neutropenia often accompanied by an increased risk of bacterial infection, and sometimes it may be a hint of some rare severe diseases. In this article, we review advances in classification, pathogenesis, diagnosis and treatment of neonatal neutropenia. Key words: Neutropenia; Infant, newborn; Sepsis; Granulocyte colony-stimulating factor; Review
{"title":"Advances in diagnosis and treatment of neonatal neutropenia","authors":"Dawei Qin","doi":"10.3760/CMA.J.ISSN.1008-1372.2020.01.047","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-1372.2020.01.047","url":null,"abstract":"Neonatal neutropenia is classified into early-onset and late-onset neutropenia. Causes of neutropenia include decreased production, increased destruction, margination in the microvascular endothelium, sequestration in the spleen, or a combination of mechanisms. Neutropenia often accompanied by an increased risk of bacterial infection, and sometimes it may be a hint of some rare severe diseases. In this article, we review advances in classification, pathogenesis, diagnosis and treatment of neonatal neutropenia. \u0000 \u0000 \u0000Key words: \u0000Neutropenia; Infant, newborn; Sepsis; Granulocyte colony-stimulating factor; Review","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79037363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-20DOI: 10.3760/CMA.J.ISSN.1008-1372.2020.01.004
Hanyu Zhang, Di Wu, Guoxing Wang
There were no obvious symptoms, no specific biochemical diagnostic indicators, and early detection and diagnosis were difficult in the early stage of cholangiocarcinoma. With the development of molecular biology, more and more biomarkers have been found in cholangiocarcinoma. It is of great significance for the early detection of cholangiocarcinoma if specific biomarkers or highly specific biomarkers can be found. Key words: Bile duct neoplasms; Biomarkers, tumor; Clinical laboratory techniques
{"title":"Progress on biomarkers for bile duct carcinoma","authors":"Hanyu Zhang, Di Wu, Guoxing Wang","doi":"10.3760/CMA.J.ISSN.1008-1372.2020.01.004","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-1372.2020.01.004","url":null,"abstract":"There were no obvious symptoms, no specific biochemical diagnostic indicators, and early detection and diagnosis were difficult in the early stage of cholangiocarcinoma. With the development of molecular biology, more and more biomarkers have been found in cholangiocarcinoma. It is of great significance for the early detection of cholangiocarcinoma if specific biomarkers or highly specific biomarkers can be found. \u0000 \u0000 \u0000Key words: \u0000Bile duct neoplasms; Biomarkers, tumor; Clinical laboratory techniques","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73022011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-20DOI: 10.3760/CMA.J.ISSN.1008-1372.2020.01.014
Jian Chen, Jian-Qing Qian, Ganhong Wang, Xiaodan Xu, Yinghong Shi, Xi Sun
Objective To evaluate the accuracy of the new non-invasive liver disease model platelet-albumin-bilirubin index (PALBI) in the diagnosis of patients with acute upper gastrointestinal hemorrhage (AUGIB) due to cirrhosis. Methods 277 patients with AUGIB due to cirrhosis were analyzed retrospectively. The data of platelet, total bilirubin, albumin, creatinine, international standardized ratio and etiology of cirrhosis were collected. Univariate and multivariate logistic regression analysis was used to identify independent risk factors for death in patients with cirrhosis complicated by AUGIB. Analysis of variance was used to compare the differences between the model for end-stage liver disease (MELD) and PALBI grades. Pearson correlation analysis was used to assess the association between MELD and PALBI. The operating characteristic curve (ROC) was used to compare the predictive power of both for short-term and long-term mortality in patients with cirrhosis complicated by AUGIB. Results The short-term and long-term mortality rates of patients with cirrhosis complicated by AUGIB were 13.7% and 23.5%, respectively. The average hospital stay was (9.1±3.9)days. The high MELD score and high PALBI index were confirmed as independent risk factors of death by single factor and multiple factors [odds ratio (OR)=1.17, 4.43; P 0.05). Conclusions PALBI has a better predictive effect on patients with cirrhosis complicated by AUGIB than MELD scores. PALBI can achieve a more precise prognosis classification for patients with MELD-a, and maintain a good prediction ability on the short-term (within 30 days of hospitalization and discharge) and long-term (within 1 year after discharge) mortality of patients. As a new liver disease model, PALBI can be used as an effective non-invasive means to judge the prognosis of patients with liver cirrhosis complicated by AUGIB . Key words: Liver cirrhosis; Acute upper gastrointestinal bleeding; PALBI score; MELD score
{"title":"A new non-invasive liver disease model to judge the prognosis of patients with acute upper gastrointestinal hemorrhage due to cirrhosis","authors":"Jian Chen, Jian-Qing Qian, Ganhong Wang, Xiaodan Xu, Yinghong Shi, Xi Sun","doi":"10.3760/CMA.J.ISSN.1008-1372.2020.01.014","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-1372.2020.01.014","url":null,"abstract":"Objective \u0000To evaluate the accuracy of the new non-invasive liver disease model platelet-albumin-bilirubin index (PALBI) in the diagnosis of patients with acute upper gastrointestinal hemorrhage (AUGIB) due to cirrhosis. \u0000 \u0000 \u0000Methods \u0000277 patients with AUGIB due to cirrhosis were analyzed retrospectively. The data of platelet, total bilirubin, albumin, creatinine, international standardized ratio and etiology of cirrhosis were collected. Univariate and multivariate logistic regression analysis was used to identify independent risk factors for death in patients with cirrhosis complicated by AUGIB. Analysis of variance was used to compare the differences between the model for end-stage liver disease (MELD) and PALBI grades. Pearson correlation analysis was used to assess the association between MELD and PALBI. The operating characteristic curve (ROC) was used to compare the predictive power of both for short-term and long-term mortality in patients with cirrhosis complicated by AUGIB. \u0000 \u0000 \u0000Results \u0000The short-term and long-term mortality rates of patients with cirrhosis complicated by AUGIB were 13.7% and 23.5%, respectively. The average hospital stay was (9.1±3.9)days. The high MELD score and high PALBI index were confirmed as independent risk factors of death by single factor and multiple factors [odds ratio (OR)=1.17, 4.43; P 0.05). \u0000 \u0000 \u0000Conclusions \u0000PALBI has a better predictive effect on patients with cirrhosis complicated by AUGIB than MELD scores. PALBI can achieve a more precise prognosis classification for patients with MELD-a, and maintain a good prediction ability on the short-term (within 30 days of hospitalization and discharge) and long-term (within 1 year after discharge) mortality of patients. As a new liver disease model, PALBI can be used as an effective non-invasive means to judge the prognosis of patients with liver cirrhosis complicated by AUGIB . \u0000 \u0000 \u0000Key words: \u0000Liver cirrhosis; Acute upper gastrointestinal bleeding; PALBI score; MELD score","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90247819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-20DOI: 10.3760/CMA.J.ISSN.1008-1372.2020.01.013
Haoran Chen, Chong-guang Lin, Langlang Cheng, Yi Xu
Objective To investigate the difference of temporary memory system and brain biochemical metabolites between patients with depressive obsessive-compulsive disorder and simple obsessive-compulsive disorder. Methods From June 2017 to June 2018, 31 patients with simple obsessive-compulsive disorder, 33 patients with depressive obsessive-compulsive disorder and 25 healthy volunteers were selected as subjects. The temporary memory ability of the three groups was tested by n-back, Stoop color association test and digital breadth test. Three brain sublimation metabolites, N-acetylaspartate acid (NAA), choline complex (Cho) and creatine (Cr), were detected by proton magnetic resonance pop (1H-MRS) in bilateral prefrontal white matter, anterior cingulate cortex and anterior cingulate cortex. The ratio of NAA/Cr and Cho/Cr was calculated with Cr as reference material. Results The scores of Yale-brown obsessive-compulsive severity scale (Y-BOCS) and Hamilton depression rating scale 24 (HAMD24) in the patients with simple obsessive-compulsive disorder and depression obsessive-compulsive disorder group were significantly higher than those in the healthy control group, and the scores of HAMD24 in the patients with depression obsessive-compulsive disorder group were significantly higher than those in the patients with simple obsessive-compulsive disorder group, with statistically significant difference (P 0.05). Compared with the healthy control group, the NAA/Cr value of bilateral prefrontal white matter in the simple obsessive-compulsive group and the depression obsessive-compulsive group was significantly lower, and the difference was statistically significant (P<0.05). Conclusions Both patients with simple obsessive-compulsive disorder and depressive obsessive-compulsive disorder had speech memory impairment and bilateral prefrontal white matter nerve function decline, while depressive obsessive-compulsive disorder patients also had central executive memory impairment. Key words: Obsessive-compulsive disorder; Depressive disorder; Memory, short-term; N-acetylaspartate; Choline complex; Creatine
{"title":"Comparison of temporary memory system and brain biochemical metabolites in patients with depressive obsessive-compulsive disorder and simple obsessive-compulsive disorder","authors":"Haoran Chen, Chong-guang Lin, Langlang Cheng, Yi Xu","doi":"10.3760/CMA.J.ISSN.1008-1372.2020.01.013","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-1372.2020.01.013","url":null,"abstract":"Objective \u0000To investigate the difference of temporary memory system and brain biochemical metabolites between patients with depressive obsessive-compulsive disorder and simple obsessive-compulsive disorder. \u0000 \u0000 \u0000Methods \u0000From June 2017 to June 2018, 31 patients with simple obsessive-compulsive disorder, 33 patients with depressive obsessive-compulsive disorder and 25 healthy volunteers were selected as subjects. The temporary memory ability of the three groups was tested by n-back, Stoop color association test and digital breadth test. Three brain sublimation metabolites, N-acetylaspartate acid (NAA), choline complex (Cho) and creatine (Cr), were detected by proton magnetic resonance pop (1H-MRS) in bilateral prefrontal white matter, anterior cingulate cortex and anterior cingulate cortex. The ratio of NAA/Cr and Cho/Cr was calculated with Cr as reference material. \u0000 \u0000 \u0000Results \u0000The scores of Yale-brown obsessive-compulsive severity scale (Y-BOCS) and Hamilton depression rating scale 24 (HAMD24) in the patients with simple obsessive-compulsive disorder and depression obsessive-compulsive disorder group were significantly higher than those in the healthy control group, and the scores of HAMD24 in the patients with depression obsessive-compulsive disorder group were significantly higher than those in the patients with simple obsessive-compulsive disorder group, with statistically significant difference (P 0.05). Compared with the healthy control group, the NAA/Cr value of bilateral prefrontal white matter in the simple obsessive-compulsive group and the depression obsessive-compulsive group was significantly lower, and the difference was statistically significant (P<0.05). \u0000 \u0000 \u0000Conclusions \u0000Both patients with simple obsessive-compulsive disorder and depressive obsessive-compulsive disorder had speech memory impairment and bilateral prefrontal white matter nerve function decline, while depressive obsessive-compulsive disorder patients also had central executive memory impairment. \u0000 \u0000 \u0000Key words: \u0000Obsessive-compulsive disorder; Depressive disorder; Memory, short-term; N-acetylaspartate; Choline complex; Creatine","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90629473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective To explore the association between Vitamin A, E and mycoplasma pneumoniae pneumonia in children. Methods 153 children with mycoplasma pneumoniae pneumonia and 653 health children were selected as cases and controls, respectively. Propensity score matching (PSM) analysis were conducted to reducing confounding bias between groups. Blood samples were collected to test serum levels of vitamin A and E using high performance liquid chromatography (HPLC). Logistic regression was implemented to determine odds ratios (OR) and 95% confidence intervals (CI) for evaluating the association of mycoplasma pneumoniae pneumonia with the serum levels of Vitamin A and E. Results After propensity score matching, the study cohort included 153 cases with mycoplasma pneumoniae pneumonia and 306 health children as controls. Before matching, with age and gender adjusted, logistic regression analysis indicated that higher serum levels of Vitamin A and E led to a lower risk of mycoplasma pneumoniae pneumonia (OR=0.075, 95% CI: 0.007-0.815; OR=0.854, 95% CI: 0.792-0.986). After matching, higher serum level of Vitamin E had a significantly lower risk of mycoplasma pneumoniae pneumonia (OR=0.877, 95% CI: 0.810-0.950). Conclusions The serum levels of Vitamin A didn't have a statistically significant association with mycoplasma pneumoniae pneumonia. However, we observed an obvious association between Vitamin E and mycoplasma pneumoniae pneumonia. Hence Vitamin E clinical monitoring and supplementation are vital for preventing and treating mycoplasma pneumoniae pneumonia. Key words: Pneumonia, mycoplasma; Vitamin A; Vitamin E; Child; Propensity score
{"title":"Study on the effect of serum vitamin A and E on children with mycoplasma pneumoniae pneumonia based on propensity score matching","authors":"Chang Xu, Liyan Luo, N. Ding, Shi-jie Jin, Shujuan Luo, Ting Yang, Bichen Wu","doi":"10.3760/CMA.J.ISSN.1008-1372.2020.01.011","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-1372.2020.01.011","url":null,"abstract":"Objective \u0000To explore the association between Vitamin A, E and mycoplasma pneumoniae pneumonia in children. \u0000 \u0000 \u0000Methods \u0000153 children with mycoplasma pneumoniae pneumonia and 653 health children were selected as cases and controls, respectively. Propensity score matching (PSM) analysis were conducted to reducing confounding bias between groups. Blood samples were collected to test serum levels of vitamin A and E using high performance liquid chromatography (HPLC). Logistic regression was implemented to determine odds ratios (OR) and 95% confidence intervals (CI) for evaluating the association of mycoplasma pneumoniae pneumonia with the serum levels of Vitamin A and E. \u0000 \u0000 \u0000Results \u0000After propensity score matching, the study cohort included 153 cases with mycoplasma pneumoniae pneumonia and 306 health children as controls. Before matching, with age and gender adjusted, logistic regression analysis indicated that higher serum levels of Vitamin A and E led to a lower risk of mycoplasma pneumoniae pneumonia (OR=0.075, 95% CI: 0.007-0.815; OR=0.854, 95% CI: 0.792-0.986). After matching, higher serum level of Vitamin E had a significantly lower risk of mycoplasma pneumoniae pneumonia (OR=0.877, 95% CI: 0.810-0.950). \u0000 \u0000 \u0000Conclusions \u0000The serum levels of Vitamin A didn't have a statistically significant association with mycoplasma pneumoniae pneumonia. However, we observed an obvious association between Vitamin E and mycoplasma pneumoniae pneumonia. Hence Vitamin E clinical monitoring and supplementation are vital for preventing and treating mycoplasma pneumoniae pneumonia. \u0000 \u0000 \u0000Key words: \u0000Pneumonia, mycoplasma; Vitamin A; Vitamin E; Child; Propensity score","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83226242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-20DOI: 10.3760/CMA.J.ISSN.1008-1372.2020.01.045
Xing Li, Yile Chen, M. Liao, W. Feng
Total hysterectomy is a treatment for cervical intraepithelial neoplasia Ⅲ (CINⅢ), and its recurrence rate is very small. In recent years, with the development of colposcopy and the increase of postoperative follow-up rate, the detection rate of vaginal intraepithelial neoplasia (VAIN) and vaginal cancer after CINⅢ hysterectomy has increased significantly. In recent years, a number of studies have found that persistent human papillomavirus (HPV) infection is the most important factor leading to the recurrence of vaginal stump after CINⅢ level hysterectomy, so eliminating HPV infection can improve the patient's performance. The prognosis of persistent HPV infection is affected by many factors. The author reviewed the factors related to the clearance of HPV after CINⅢ hysterectomy. The purpose of this study is to provide a theoretical basis for improving the prognosis of patients and delaying the recurrence time after CINⅢ hysterectomy. Key words: Cervical intraepithelial neoplasia; Hysterectomy; Human papillomavirus; Review
{"title":"Research progress of the factors affecting human papillomavirus clearance after CINIII hysterectomy","authors":"Xing Li, Yile Chen, M. Liao, W. Feng","doi":"10.3760/CMA.J.ISSN.1008-1372.2020.01.045","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-1372.2020.01.045","url":null,"abstract":"Total hysterectomy is a treatment for cervical intraepithelial neoplasia Ⅲ (CINⅢ), and its recurrence rate is very small. In recent years, with the development of colposcopy and the increase of postoperative follow-up rate, the detection rate of vaginal intraepithelial neoplasia (VAIN) and vaginal cancer after CINⅢ hysterectomy has increased significantly. In recent years, a number of studies have found that persistent human papillomavirus (HPV) infection is the most important factor leading to the recurrence of vaginal stump after CINⅢ level hysterectomy, so eliminating HPV infection can improve the patient's performance. The prognosis of persistent HPV infection is affected by many factors. The author reviewed the factors related to the clearance of HPV after CINⅢ hysterectomy. The purpose of this study is to provide a theoretical basis for improving the prognosis of patients and delaying the recurrence time after CINⅢ hysterectomy. \u0000 \u0000 \u0000Key words: \u0000Cervical intraepithelial neoplasia; Hysterectomy; Human papillomavirus; Review","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84386452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-20DOI: 10.3760/CMA.J.ISSN.1008-1372.2019.12.008
Min Xu, D. Huai, Dong-Su Yu
Objective To evaluate the value of 320-slice computed tomography (CT) " double-low" maximum density projection (MIP) imaging protocol (low tube voltage and low contrast agent concentration) in obstructive sleep apnea syndrome (OSAS) with coronary heart disease. Methods 40 cases of OSAS with coronary heart disease in our hospital were selected. All patients underwent 320-slice CT " double-low" MIP imaging and received conventional coronary angiography (CAG) within 1 month. With reference to CAG examination results, the accuracy of 320-slice CT " double low" MIP-imaging technique in diagnosing the Obstructive sleep apnea syndrome with coronary heart disease can be evaluated. Results The sensitivity, specificity, accuracy, positive predictive value and negative predictive value of 320-slice CT" double-low " MIP imaging in the diagnosis of obstructive respiratory sleep disorder with coronary disease were 95.14%, 94.43%, 95.33%, 83.62%, 98.20%. respectively. The heart rate of testers was (65.20±4.79)bpm/min, the dose length product (DLP) was (98.22±32.54)mGy·cm, and the effective radiation dose (ED) was (1.35±0.42)mSv. Conclusions Compared with CAG, the 320-slice CT " double-low" MIP imaging technique reduced doses of radiation while maintained the good quality of image. Therefore, this technique has high application value as a clinical diagnosis method to diagnose patients with obstructive respiratory sleep disorder and coronary heart disease. Key words: Sleep apnea, obstructive; Coronary disease; Tomography, X-ray computed
{"title":"The application of 320-slice CT \" double-low\" MIP imaging technique in obstructive sleep apnea syndrome with coronary heart disease","authors":"Min Xu, D. Huai, Dong-Su Yu","doi":"10.3760/CMA.J.ISSN.1008-1372.2019.12.008","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-1372.2019.12.008","url":null,"abstract":"Objective \u0000To evaluate the value of 320-slice computed tomography (CT) \" double-low\" maximum density projection (MIP) imaging protocol (low tube voltage and low contrast agent concentration) in obstructive sleep apnea syndrome (OSAS) with coronary heart disease. \u0000 \u0000 \u0000Methods \u000040 cases of OSAS with coronary heart disease in our hospital were selected. All patients underwent 320-slice CT \" double-low\" MIP imaging and received conventional coronary angiography (CAG) within 1 month. With reference to CAG examination results, the accuracy of 320-slice CT \" double low\" MIP-imaging technique in diagnosing the Obstructive sleep apnea syndrome with coronary heart disease can be evaluated. \u0000 \u0000 \u0000Results \u0000The sensitivity, specificity, accuracy, positive predictive value and negative predictive value of 320-slice CT\" double-low \" MIP imaging in the diagnosis of obstructive respiratory sleep disorder with coronary disease were 95.14%, 94.43%, 95.33%, 83.62%, 98.20%. respectively. The heart rate of testers was (65.20±4.79)bpm/min, the dose length product (DLP) was (98.22±32.54)mGy·cm, and the effective radiation dose (ED) was (1.35±0.42)mSv. \u0000 \u0000 \u0000Conclusions \u0000Compared with CAG, the 320-slice CT \" double-low\" MIP imaging technique reduced doses of radiation while maintained the good quality of image. Therefore, this technique has high application value as a clinical diagnosis method to diagnose patients with obstructive respiratory sleep disorder and coronary heart disease. \u0000 \u0000 \u0000Key words: \u0000Sleep apnea, obstructive; Coronary disease; Tomography, X-ray computed","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79642969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-20DOI: 10.3760/CMA.J.ISSN.1008-1372.2019.12.019
H. Xiong
Objective To explore the value of ultrasound quantitative scoring and ultrasound elastography in the diagnosis and differential diagnosis of thyroid space occupying lesions. Methods 193 patients with nodular thyroid lesions (245 thyroid nodules in total) diagnosed from January 2016 to December 2017 were selected as the study objects. The pathological results were used as the gold standard to draw the receiver operating characteristic (ROC) of the patients with malignant lesions predicted by conventional ultrasound quantitative score and ultrasound elastic imaging grading, and calculate the sensitivity, specificity, positive predictive value and negative predictive value predictive value, accuracy, area under curve (AUC) and 95% CI. Results Of 245 thyroid nodules, 174 were benign and 71 were malignant.The results of conventional ultrasound quantitative score showed that 70 of 193 patients had ultrasound quantitative score ≥4, and 74 of them had ultrasound elastic imaging grade of 4-5. The results of conventional ultrasound quantitative score showed that 70 of 193 patients had ultrasound quantitative score ≥ 4, and 74 of them had ultrasound elastic imaging grade of 4-5. 72 malignant nodules were detected by conventional ultrasound quantitative score, 52 were diagnosed correctly, 19 were missed and 20 were misdiagnosed. 75 malignant nodules were detected by ultrasound elastic imaging, 64 were diagnosed correctly, 7 were missed and 11 were misdiagnosed. The sensitivity and AUC of ultrasound elastic imaging were higher than that of ultrasound quantitative scoring (P<0.05), and the specificity of ultrasound quantitative scoring and elastic imaging positive were higher than that of ultrasound quantitative score combine with ultrasound elastic imaging, with statistically significant difference (P<0.05). The sensitivity of quantitative ultrasound scoring positive or elastography positive was higher than that of quantitative ultrasound scoring, elastography, quantitative and elastography, and the specificity was lower than that of quantitative and elastography, with statistically significant difference (P<0.05). Conclusions The clinical value of ultrasound elastography in the diagnosis of thyroid malignant nodule is better than that of conventional ultrasound quantitative scoring. The combination of the two methods is helpful to the diagnosis and exclusion of thyroid malignant nodule, which can be flexibly used according to the actual situation. Key words: Thyroid nodule; Thyroid neoplasms; Elasticity imaging techniques; Diagnosis, differential
{"title":"Value of ultrasound quantitative scoring and ultrasound elastography in the diagnosis and differential diagnosis of thyroid space occupying lesions","authors":"H. Xiong","doi":"10.3760/CMA.J.ISSN.1008-1372.2019.12.019","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-1372.2019.12.019","url":null,"abstract":"Objective \u0000To explore the value of ultrasound quantitative scoring and ultrasound elastography in the diagnosis and differential diagnosis of thyroid space occupying lesions. \u0000 \u0000 \u0000Methods \u0000193 patients with nodular thyroid lesions (245 thyroid nodules in total) diagnosed from January 2016 to December 2017 were selected as the study objects. The pathological results were used as the gold standard to draw the receiver operating characteristic (ROC) of the patients with malignant lesions predicted by conventional ultrasound quantitative score and ultrasound elastic imaging grading, and calculate the sensitivity, specificity, positive predictive value and negative predictive value predictive value, accuracy, area under curve (AUC) and 95% CI. \u0000 \u0000 \u0000Results \u0000Of 245 thyroid nodules, 174 were benign and 71 were malignant.The results of conventional ultrasound quantitative score showed that 70 of 193 patients had ultrasound quantitative score ≥4, and 74 of them had ultrasound elastic imaging grade of 4-5. The results of conventional ultrasound quantitative score showed that 70 of 193 patients had ultrasound quantitative score ≥ 4, and 74 of them had ultrasound elastic imaging grade of 4-5. 72 malignant nodules were detected by conventional ultrasound quantitative score, 52 were diagnosed correctly, 19 were missed and 20 were misdiagnosed. 75 malignant nodules were detected by ultrasound elastic imaging, 64 were diagnosed correctly, 7 were missed and 11 were misdiagnosed. The sensitivity and AUC of ultrasound elastic imaging were higher than that of ultrasound quantitative scoring (P<0.05), and the specificity of ultrasound quantitative scoring and elastic imaging positive were higher than that of ultrasound quantitative score combine with ultrasound elastic imaging, with statistically significant difference (P<0.05). The sensitivity of quantitative ultrasound scoring positive or elastography positive was higher than that of quantitative ultrasound scoring, elastography, quantitative and elastography, and the specificity was lower than that of quantitative and elastography, with statistically significant difference (P<0.05). \u0000 \u0000 \u0000Conclusions \u0000The clinical value of ultrasound elastography in the diagnosis of thyroid malignant nodule is better than that of conventional ultrasound quantitative scoring. The combination of the two methods is helpful to the diagnosis and exclusion of thyroid malignant nodule, which can be flexibly used according to the actual situation. \u0000 \u0000 \u0000Key words: \u0000Thyroid nodule; Thyroid neoplasms; Elasticity imaging techniques; Diagnosis, differential","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90078681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2019-12-20DOI: 10.3760/CMA.J.ISSN.1008-1372.2019.12.047
Li Dong, Xiaoguang Luo
Parkinson's disease is a common neurodegenerative disease. At present, many studies have considered that Parkinson's disease is related to chronic inflammation in the brain, and the activation and subside of peripheral inflammation affect the inflammation in the brain.Therefore, this paper reviews the relationship between peripheral inflammation, neuroinflammation and Parkinson's disease. Key words: Parkinson disease; Inflammation; Review
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Pub Date : 2019-12-20DOI: 10.3760/CMA.J.ISSN.1008-1372.2019.12.001
Yongquan Gu, Xixiang Gao
About 25%-40% of ischemic stroke is in the posterior circulation, in which 20% of posterior circulation stroke is caused by vertebral artery stenosis. Patients with symptomatic vertebral artery stenosis have a high risk of recurrent stroke. At present, the treatments of vertebral artery stenosis include medication, open surgery and interventional therapy. In this paper, the endovascular treatment of vertebral artery stenosis is reviewed, especially the progress of endovascular treatment is expounded, in order to promote the development of its treatment. Key words: Brain ischemia; Vertebral artery stenosis; Angioplasty, balloon; Drug-eluting stents; Atherectomy
{"title":"Endovascular treatment of symptomatic severe vertebral artery stenosis","authors":"Yongquan Gu, Xixiang Gao","doi":"10.3760/CMA.J.ISSN.1008-1372.2019.12.001","DOIUrl":"https://doi.org/10.3760/CMA.J.ISSN.1008-1372.2019.12.001","url":null,"abstract":"About 25%-40% of ischemic stroke is in the posterior circulation, in which 20% of posterior circulation stroke is caused by vertebral artery stenosis. Patients with symptomatic vertebral artery stenosis have a high risk of recurrent stroke. At present, the treatments of vertebral artery stenosis include medication, open surgery and interventional therapy. In this paper, the endovascular treatment of vertebral artery stenosis is reviewed, especially the progress of endovascular treatment is expounded, in order to promote the development of its treatment. \u0000 \u0000 \u0000Key words: \u0000Brain ischemia; Vertebral artery stenosis; Angioplasty, balloon; Drug-eluting stents; Atherectomy","PeriodicalId":15276,"journal":{"name":"中国医师杂志","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76173248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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