Mohammed Fareedullah, Zareen Unnisa, Shajiya Khan, F. Fatima, Afifa Khan, S. Farees, M. Khaleel
Aim: To evaluate the antibiotic usage in skin and soft-tissue infections (SSTIs) and to study the sensitivity pattern of identified microorganisms from antimicrobial susceptibility testing (AST) data. Materials and Methods: This was a cross-sectional study carried out in the Inpatient Department of General Surgery at Owaisi Hospital & Research Center, Hyderabad, for 6 months to collect 50 swab samples aseptically from the subjects with diverse SSTIs at the day of admission before the administration of antibiotics, and AST was done using Kirby Bauer disc diffusion method based on the guidelines of Clinical Laboratory Standard Institute (CLSI). Results: Of the 50 swab samples, 43 were culture positive and 7 were culture negative, and the highest number of cases was of cellulitis (14.28%). The most commonly isolated pathogen was Staphylococcus aureus (30.23%). On the basis of antibiotic sensitivity testing, we found that Ciprofloxacin was the most potent drug, followed by Ceftriaxone and Amikacin, for overall bacterial isolates. In our study, the treatment adhered to IDSA guidelines in 50% of cases and we found that many antibiotics were resistant. In cases of gangrene and abscess, a striking deviation from the guidelines (60% and 77.7%, respectively) was seen. Conclusion: This study guided us toward an appropriate treatment plan for the management of some SSTIs. The disproportionate and tedious use of antibiotics should be abstained as this may drive the evolution of resistant microorganisms that are even more difficult to get rid of.
{"title":"Evaluation of antibiotic usage in skin and soft-tissue infections and its antimicrobial susceptibility testing: A hospital-based cross-sectional study","authors":"Mohammed Fareedullah, Zareen Unnisa, Shajiya Khan, F. Fatima, Afifa Khan, S. Farees, M. Khaleel","doi":"10.4103/jhrr.jhrr_34_20","DOIUrl":"https://doi.org/10.4103/jhrr.jhrr_34_20","url":null,"abstract":"Aim: To evaluate the antibiotic usage in skin and soft-tissue infections (SSTIs) and to study the sensitivity pattern of identified microorganisms from antimicrobial susceptibility testing (AST) data. Materials and Methods: This was a cross-sectional study carried out in the Inpatient Department of General Surgery at Owaisi Hospital & Research Center, Hyderabad, for 6 months to collect 50 swab samples aseptically from the subjects with diverse SSTIs at the day of admission before the administration of antibiotics, and AST was done using Kirby Bauer disc diffusion method based on the guidelines of Clinical Laboratory Standard Institute (CLSI). Results: Of the 50 swab samples, 43 were culture positive and 7 were culture negative, and the highest number of cases was of cellulitis (14.28%). The most commonly isolated pathogen was Staphylococcus aureus (30.23%). On the basis of antibiotic sensitivity testing, we found that Ciprofloxacin was the most potent drug, followed by Ceftriaxone and Amikacin, for overall bacterial isolates. In our study, the treatment adhered to IDSA guidelines in 50% of cases and we found that many antibiotics were resistant. In cases of gangrene and abscess, a striking deviation from the guidelines (60% and 77.7%, respectively) was seen. Conclusion: This study guided us toward an appropriate treatment plan for the management of some SSTIs. The disproportionate and tedious use of antibiotics should be abstained as this may drive the evolution of resistant microorganisms that are even more difficult to get rid of.","PeriodicalId":16068,"journal":{"name":"Journal of Health Research and Reviews","volume":"20 1","pages":"27 - 33"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72969392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-01DOI: 10.4103/2394-2010.317209
{"title":"Erratum: Renal cysts: Sonographic evaluation and classification in sudanese adults","authors":"","doi":"10.4103/2394-2010.317209","DOIUrl":"https://doi.org/10.4103/2394-2010.317209","url":null,"abstract":"","PeriodicalId":16068,"journal":{"name":"Journal of Health Research and Reviews","volume":"54 1","pages":"34 - 34"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73584309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Soybean is a species of legume native to Southeast Asia. It is widely grown as it is widely used in producing foods and food additives. The categories of soy protein differ according to their production methods, which ranges from isolated to concentrated and textured soy protein. The direct effect of soy bean on health and its mechanism of work are yet unclear and is still a controversial issue that needs to be investigated. Aim: To provide an overview of existing soybean and health-related research studies and to identify the positive and negative effects if found especially for heart diseases and cancers. Materials and Methods: A search of periodical literature by the author involving dietary therapy and soybean was carried out. Items were identified initially through health-oriented indexing services such as Medline, Health STAR, and Cinahl, looking up for articles published in English language, from 2010 to 2020. Keywords included “Isoflavones,” “soybean,” “cancer,” “Tofu,” and “heart disease.”Results: Researches are still controversial, some studies acknowledged the soybean product’s efficacy in preventing diseases such as heart diseases and cancers, while others found no or negative effects on health. Conclusion: The risk/benefit status of soy products as beneficial supplements continues to be controversial. To conclude, it can be confirmed that 12–25 gm of soy with 75 gm of isoflavones daily (2–4 servings of soy foods per day) can improve the estrogen level along with lipid profile and offer benefits to the cardiovascular system and estrogen deficit symptoms. Most populations should not exceed the recommended amount and the effectiveness of using soybeans should be matched with tolerance and compliance to reach the desirable improvements.
{"title":"The modest hormonal effects of soy isoflavones: What do we really know? A narrative review","authors":"L. Mahmood, L. Matthews","doi":"10.4103/jhrr.jhrr_30_20","DOIUrl":"https://doi.org/10.4103/jhrr.jhrr_30_20","url":null,"abstract":"Background: Soybean is a species of legume native to Southeast Asia. It is widely grown as it is widely used in producing foods and food additives. The categories of soy protein differ according to their production methods, which ranges from isolated to concentrated and textured soy protein. The direct effect of soy bean on health and its mechanism of work are yet unclear and is still a controversial issue that needs to be investigated. Aim: To provide an overview of existing soybean and health-related research studies and to identify the positive and negative effects if found especially for heart diseases and cancers. Materials and Methods: A search of periodical literature by the author involving dietary therapy and soybean was carried out. Items were identified initially through health-oriented indexing services such as Medline, Health STAR, and Cinahl, looking up for articles published in English language, from 2010 to 2020. Keywords included “Isoflavones,” “soybean,” “cancer,” “Tofu,” and “heart disease.”Results: Researches are still controversial, some studies acknowledged the soybean product’s efficacy in preventing diseases such as heart diseases and cancers, while others found no or negative effects on health. Conclusion: The risk/benefit status of soy products as beneficial supplements continues to be controversial. To conclude, it can be confirmed that 12–25 gm of soy with 75 gm of isoflavones daily (2–4 servings of soy foods per day) can improve the estrogen level along with lipid profile and offer benefits to the cardiovascular system and estrogen deficit symptoms. Most populations should not exceed the recommended amount and the effectiveness of using soybeans should be matched with tolerance and compliance to reach the desirable improvements.","PeriodicalId":16068,"journal":{"name":"Journal of Health Research and Reviews","volume":"192 1","pages":"18 - 22"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89623199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Dyslipidemia is a situation of abnormal blood lipids. It is considered as a major risk factor for cardiovascular disease (CVD). Healthy diet is found to be effective in reducing serum cholesterol; thus, using foods that are high in components and that help in reducing cholesterol is recommended. These foods include fruits, green vegetables, avocado, almond, nuts, and fish oil. The aim was to provide an overview of existing research studies and their approaches regarding the effect of dietary and lifestyle modifications in reducing hypercholesterolemia. Materials and Methods: A search of periodical literature by the author involving dietary therapy and soybean was carried out. Items were identified initially through health-oriented indexing services such as Medline, Health STAR, and Cinahl, looking up for articles published in the English language, from 2010 to 2020. Keywords included “Cholesterol,” “Lipid,” “Dyslipidemia,” “Diet,” “and Health.”Results: Those consuming a daily average of 78g of almonds showed a reduction of LDL-cholesterol by 9.4% whereas those consuming 37g/day showed a reduction of LDL-cholesterol by 4.4%, with a significant increase in HDL levels and a decrease in lipoprotein A. It appears that the consumption of soluble fibers can promote a moderate effect in lowering cholesterol in patients with hypercholesterolemia. Studies have shown that fibers seem to act synergistically at the recommended intake dose of total fiber 25g, including 6g from soluble fibers intake. Conclusion: Dietary modification is found to be a powerful nonpharmacological approach that helps in improving blood lipids. Lipid profiles can be improved indirectly through changing the unhealth, performing physical activity, and reducing body weight.
{"title":"Effectiveness of altering hypercholesterolaemia without drugs: Evidence of lifestyle modifications: A narrative review","authors":"L. Mahmood, L. Matthews","doi":"10.4103/jhrr.jhrr_27_20","DOIUrl":"https://doi.org/10.4103/jhrr.jhrr_27_20","url":null,"abstract":"Background: Dyslipidemia is a situation of abnormal blood lipids. It is considered as a major risk factor for cardiovascular disease (CVD). Healthy diet is found to be effective in reducing serum cholesterol; thus, using foods that are high in components and that help in reducing cholesterol is recommended. These foods include fruits, green vegetables, avocado, almond, nuts, and fish oil. The aim was to provide an overview of existing research studies and their approaches regarding the effect of dietary and lifestyle modifications in reducing hypercholesterolemia. Materials and Methods: A search of periodical literature by the author involving dietary therapy and soybean was carried out. Items were identified initially through health-oriented indexing services such as Medline, Health STAR, and Cinahl, looking up for articles published in the English language, from 2010 to 2020. Keywords included “Cholesterol,” “Lipid,” “Dyslipidemia,” “Diet,” “and Health.”Results: Those consuming a daily average of 78g of almonds showed a reduction of LDL-cholesterol by 9.4% whereas those consuming 37g/day showed a reduction of LDL-cholesterol by 4.4%, with a significant increase in HDL levels and a decrease in lipoprotein A. It appears that the consumption of soluble fibers can promote a moderate effect in lowering cholesterol in patients with hypercholesterolemia. Studies have shown that fibers seem to act synergistically at the recommended intake dose of total fiber 25g, including 6g from soluble fibers intake. Conclusion: Dietary modification is found to be a powerful nonpharmacological approach that helps in improving blood lipids. Lipid profiles can be improved indirectly through changing the unhealth, performing physical activity, and reducing body weight.","PeriodicalId":16068,"journal":{"name":"Journal of Health Research and Reviews","volume":"8 1","pages":"6 - 12"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88691219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aim: Children’s nutritional status offers valuable insights into the future of society’s well-being. Street children are quite vulnerable to poor health and malnutrition. The purpose of this study was to assess the health and nutritional status of street children in Accra, Ghana. Materials and Methods: A total of 300 children (210 males and 90 females) aged 10–17 years were recruited for the study. Anthropometric measurements included height, weight, mid-upper arm circumference, and triceps and calf skinfolds. Quality of diet and nutritional habits (number of meals per day and frequency of consuming particular foods) were studied using a 24-h dietary recall and food frequency questionnaires. Results: The mean age of the children was 14.8 years. Approximately 74.7% of them had at most primary education. The majority (65%) of the children lived on their own and the major economic activity engaged by them was hawking, and the average earnings per day were approximately US$1.00. The mean caloric intake of respondents was 1395 ± 483.63 kcal. Mean intake of vitamin A and iron among the children was 1054.63 ± 1222.84 retinol equivalent and 18.16 ± 10.28mg/day, respectively. Mean calcium intake was 424.57 ± 200.29mg/day. Children who were stunted formed 17.7% of respondents, 92.7% of them had normal range of body mass index (BMI), and 5.3% were underweight. Generally, BMI was higher in females compared to that in males. Conclusion: On the basis of findings, it could be concluded that street children were not adequately nourished and were highly susceptible to micronutrient deficiencies, stunting, and underweight. This calls for immediate action to put measures in place to combat this public health concern.
{"title":"Health and nutritional conditions of street children of Accra City Centers: An experiential study in Ghana","authors":"F. Vuvor, P. Mensah","doi":"10.4103/jhrr.jhrr_34_19","DOIUrl":"https://doi.org/10.4103/jhrr.jhrr_34_19","url":null,"abstract":"Aim: Children’s nutritional status offers valuable insights into the future of society’s well-being. Street children are quite vulnerable to poor health and malnutrition. The purpose of this study was to assess the health and nutritional status of street children in Accra, Ghana. Materials and Methods: A total of 300 children (210 males and 90 females) aged 10–17 years were recruited for the study. Anthropometric measurements included height, weight, mid-upper arm circumference, and triceps and calf skinfolds. Quality of diet and nutritional habits (number of meals per day and frequency of consuming particular foods) were studied using a 24-h dietary recall and food frequency questionnaires. Results: The mean age of the children was 14.8 years. Approximately 74.7% of them had at most primary education. The majority (65%) of the children lived on their own and the major economic activity engaged by them was hawking, and the average earnings per day were approximately US$1.00. The mean caloric intake of respondents was 1395 ± 483.63 kcal. Mean intake of vitamin A and iron among the children was 1054.63 ± 1222.84 retinol equivalent and 18.16 ± 10.28mg/day, respectively. Mean calcium intake was 424.57 ± 200.29mg/day. Children who were stunted formed 17.7% of respondents, 92.7% of them had normal range of body mass index (BMI), and 5.3% were underweight. Generally, BMI was higher in females compared to that in males. Conclusion: On the basis of findings, it could be concluded that street children were not adequately nourished and were highly susceptible to micronutrient deficiencies, stunting, and underweight. This calls for immediate action to put measures in place to combat this public health concern.","PeriodicalId":16068,"journal":{"name":"Journal of Health Research and Reviews","volume":"61 11","pages":"89 - 94"},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91485861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Clinical laboratory testing is an important part of health-care services. Medical laboratories play a pivotal role in the health-care system and the decision-making of clinical doctors about their patients. In the era of consumer protection, everyone is aware of and tries to ensure quality health-care services to all. However, medical errors may sometimes cause undesirable consequences to patients. Therefore, it is important to know the types of errors occurring in laboratories in order to formulate strategies to prevent these. Although literature reporting errors in biochemistry laboratory is available, the literature pertaining to pathology and microbiology laboratories is very limited. Aims: This was a cross-sectional study done in pathology and microbiology laboratories of a tertiary care teaching hospital. Our study aimed to find different errors in these departments and also perform root cause analyses of these errors. Materials and Methods: The study was conducted for a period of 3 months. All the requisition forms, specimens, entered reports, and certified reports were scrutinized, and any error observed as per predefined categories was recorded. Errors that were noticed by laboratory personnel, laboratory doctors, clinicians, and nurses in the wards were included in this study. Each error was documented, and root cause analysis of the same was also done. Data were compiled on Microsoft excel worksheets (Microsoft Office Excel 2007, Redwoods, WA, USA) analyzed with GraphPad Prism 5 (GraphPad Software Inc., CA, USA). Chi-square test was applied to compare categorical data. Results: Among a total of 21,746 tests, a number of errors recorded were 304 (1.4%). The most common errors observed were preanalytical (64.5%), followed by postanalytical (18.1%) and analytical (17.4%). Conclusion: An error detection program must be in place, and it has to be acknowledged in order to ensure patients’ safety. Adequate measures must be adopted to reduce errors in laboratory.
{"title":"An evaluation of the errors occurring in pathology and microbiology laboratories of a tertiary care teaching hospital and their root cause analyses","authors":"A. Roy, D. Das","doi":"10.4103/jhrr.jhrr_38_19","DOIUrl":"https://doi.org/10.4103/jhrr.jhrr_38_19","url":null,"abstract":"Background: Clinical laboratory testing is an important part of health-care services. Medical laboratories play a pivotal role in the health-care system and the decision-making of clinical doctors about their patients. In the era of consumer protection, everyone is aware of and tries to ensure quality health-care services to all. However, medical errors may sometimes cause undesirable consequences to patients. Therefore, it is important to know the types of errors occurring in laboratories in order to formulate strategies to prevent these. Although literature reporting errors in biochemistry laboratory is available, the literature pertaining to pathology and microbiology laboratories is very limited. Aims: This was a cross-sectional study done in pathology and microbiology laboratories of a tertiary care teaching hospital. Our study aimed to find different errors in these departments and also perform root cause analyses of these errors. Materials and Methods: The study was conducted for a period of 3 months. All the requisition forms, specimens, entered reports, and certified reports were scrutinized, and any error observed as per predefined categories was recorded. Errors that were noticed by laboratory personnel, laboratory doctors, clinicians, and nurses in the wards were included in this study. Each error was documented, and root cause analysis of the same was also done. Data were compiled on Microsoft excel worksheets (Microsoft Office Excel 2007, Redwoods, WA, USA) analyzed with GraphPad Prism 5 (GraphPad Software Inc., CA, USA). Chi-square test was applied to compare categorical data. Results: Among a total of 21,746 tests, a number of errors recorded were 304 (1.4%). The most common errors observed were preanalytical (64.5%), followed by postanalytical (18.1%) and analytical (17.4%). Conclusion: An error detection program must be in place, and it has to be acknowledged in order to ensure patients’ safety. Adequate measures must be adopted to reduce errors in laboratory.","PeriodicalId":16068,"journal":{"name":"Journal of Health Research and Reviews","volume":"43 1","pages":"102 - 106"},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74202825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background and Aims: Laryngeal papillomatosis is an uncommon disease in pediatric age caused by the human papilloma virus, which presents as warty, exophytic growths in the larynx. Children having laryngeal papillomatosis frequently present with dysphonia. It can lead to severe airway obstruction and voice change. The aim of this study was to assess the detailed clinical presentations, treatment options, and outcome of the laryngeal papillomatosis in pediatric patients. Materials and Methods: This was a prospective study carried out among pediatric age group (n = 21) and among those who underwent surgical treatment with different modalities such as coblation, microdebrider, and laser on diagnosed cases of laryngeal papillomatosis during December 2015 to March 2019. Clinical presentations and detailed patient profile including maternal aspects were documented. Details of previous surgeries conducted on the child’s larynx were also recorded. Results: Dysphonia is the most common clinical presentation. Of 21 children, 12 were boys and 9 were girls. The mean age was 11.52 years. No child with a history of immunodeficiency or exposure to smoking was reported. Of 21 children, 9 had a history of previous surgeries for laryngeal papillomatosis. There were five primiparous mothers in this study and they are considered as as risk factors. One child underwent tracheostomy due to compromised airway by laryngeal papillomatosis. Coblation and microdebrider are common and effective techniques performed among children with laryngeal papillomatosis. Conclusion: Coblation and microdebrider were found to be safe and cost-effective than laser and coblation. Only maternal risk factor in this study was primiparous mother. Children with laryngeal papillomatosis were associated with multiple surgeries in the past due to recurrence and aggressive nature of the disease. Very young children and patients with tracheostomy needed strict follow-up in case of severe diseases.
{"title":"Pediatric Laryngeal Papillomatosis: Experiences at an Indian Teaching Hospital","authors":"S. Swain, I. Behera, Loknath Sahoo","doi":"10.4103/jhrr.jhrr_45_19","DOIUrl":"https://doi.org/10.4103/jhrr.jhrr_45_19","url":null,"abstract":"Background and Aims: Laryngeal papillomatosis is an uncommon disease in pediatric age caused by the human papilloma virus, which presents as warty, exophytic growths in the larynx. Children having laryngeal papillomatosis frequently present with dysphonia. It can lead to severe airway obstruction and voice change. The aim of this study was to assess the detailed clinical presentations, treatment options, and outcome of the laryngeal papillomatosis in pediatric patients. Materials and Methods: This was a prospective study carried out among pediatric age group (n = 21) and among those who underwent surgical treatment with different modalities such as coblation, microdebrider, and laser on diagnosed cases of laryngeal papillomatosis during December 2015 to March 2019. Clinical presentations and detailed patient profile including maternal aspects were documented. Details of previous surgeries conducted on the child’s larynx were also recorded. Results: Dysphonia is the most common clinical presentation. Of 21 children, 12 were boys and 9 were girls. The mean age was 11.52 years. No child with a history of immunodeficiency or exposure to smoking was reported. Of 21 children, 9 had a history of previous surgeries for laryngeal papillomatosis. There were five primiparous mothers in this study and they are considered as as risk factors. One child underwent tracheostomy due to compromised airway by laryngeal papillomatosis. Coblation and microdebrider are common and effective techniques performed among children with laryngeal papillomatosis. Conclusion: Coblation and microdebrider were found to be safe and cost-effective than laser and coblation. Only maternal risk factor in this study was primiparous mother. Children with laryngeal papillomatosis were associated with multiple surgeries in the past due to recurrence and aggressive nature of the disease. Very young children and patients with tracheostomy needed strict follow-up in case of severe diseases.","PeriodicalId":16068,"journal":{"name":"Journal of Health Research and Reviews","volume":"21 1","pages":"114 - 121"},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75655287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Major orthopedic surgeries carry a high risk of venous thromboembolism. Enoxaparin has been in use for this indication for a long time. Fondaparinux, a relatively new anticoagulant, has also shown favorable results. Till date, there are limited studies comparing the safety of fondaparinux with enoxaparin in Indian patients undergoing major orthopedic surgery. Aim: The aim of this study was to compare the safety of fondaparinux with enoxaparin in the real-life setting. Materials and Methods: Patients who underwent hemiarthroplasty between January 2016 and December 2017, and who were administered fondaparinux or enoxaparin were retrospectively analyzed using patient case files, discharge database, and blood bank database. The safety was assessed based on the requirement of blood transfusion, need for reexploration, wound complications, any occurrence of bleeding, and death from all causes. Pearson’s chi-square test was used using the Statistical Package for the Social Sciences (SPSS) software (IBM, India), version 16. Results: The safety profile of fondaparinux was comparable with enoxaparin with regard to occurrence of bleeding, transfusion requirements, wound complications, and need for reexploration. A higher proportion of patients on fondaparinux had to be given blood transfusion, though this difference was not statistically significant (P = 0.120). Conclusion: In patients who underwent hemiarthroplasty, safety of fondaparinux was comparable to enoxaparin in actual clinical experience.
{"title":"A retrospective observational study to compare the safety of fondaparinux versus enoxaparin among patients who underwent hemiarthroplasty","authors":"S. Gopinath, A. Pillai","doi":"10.4103/jhrr.jhrr_50_19","DOIUrl":"https://doi.org/10.4103/jhrr.jhrr_50_19","url":null,"abstract":"Background: Major orthopedic surgeries carry a high risk of venous thromboembolism. Enoxaparin has been in use for this indication for a long time. Fondaparinux, a relatively new anticoagulant, has also shown favorable results. Till date, there are limited studies comparing the safety of fondaparinux with enoxaparin in Indian patients undergoing major orthopedic surgery. Aim: The aim of this study was to compare the safety of fondaparinux with enoxaparin in the real-life setting. Materials and Methods: Patients who underwent hemiarthroplasty between January 2016 and December 2017, and who were administered fondaparinux or enoxaparin were retrospectively analyzed using patient case files, discharge database, and blood bank database. The safety was assessed based on the requirement of blood transfusion, need for reexploration, wound complications, any occurrence of bleeding, and death from all causes. Pearson’s chi-square test was used using the Statistical Package for the Social Sciences (SPSS) software (IBM, India), version 16. Results: The safety profile of fondaparinux was comparable with enoxaparin with regard to occurrence of bleeding, transfusion requirements, wound complications, and need for reexploration. A higher proportion of patients on fondaparinux had to be given blood transfusion, though this difference was not statistically significant (P = 0.120). Conclusion: In patients who underwent hemiarthroplasty, safety of fondaparinux was comparable to enoxaparin in actual clinical experience.","PeriodicalId":16068,"journal":{"name":"Journal of Health Research and Reviews","volume":"10 1","pages":"122 - 125"},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86211994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Y. Lawal, Sanusi Muhammad, U. Dahuwa, I. Bichi, Hayat Ahmed
Background: The prevalence of type 2 diabetes is increasing worldwide, and according to the International Diabetes Federation, one in every two i.e. 212 million people with diabetes is undiagnosed. This screening exercise was carried out during the World Diabetes Day celebration in line with global efforts toward early detection of persons with glucose intolerance. Aim: The aim of this study was to determine the prevalence of obesity and undiscovered glucose intolerance among the hospital employees and to assess the relationship among blood glucose level, some obesity indices, and blood pressure. No such study was ever carried out in this hospital and it afforded the employees the opportunity to get enlightened about the menace of obesity and diabetes. Materials and Methods: The screening exercise was approved by the hospital management after due ethical consideration. Consent was obtained from each participant and then some anthropometric indices and 2-h postprandial plasma glucose level were measured. Data were entered into Microsoft Excel, and then analyzed using IBM Statistical Package for the Social Sciences (SPSS) software, version 23. Results: The prevalence of obesity by body mass index, waist circumference, and waist-height ratio criteria was 17.4%, 33.7%, and 55.8%, respectively, and was more common among females. The prevalence of previously undiagnosed glucose intolerance was 12.7% (impaired glucose tolerance [IGT], 11.5% and diabetes mellitus, 1.2%) and the proportion among females and males was 12.5% and 11.9%, respectively. Conclusion: Though the prevalence of undiscovered diabetes was low, the prevalence of obesity and IGT was high, suggesting a population in transition from low prevalence to high prevalence of diabetes. In addition, obesity and glucose intolerance were more common among female compared to those among male participants.
背景:世界范围内2型糖尿病的患病率正在上升，根据国际糖尿病联合会的数据，每两个糖尿病患者中就有一个，即2.12亿人未被诊断出来。这项筛查活动是在世界糖尿病日庆祝活动期间进行的，与全球早期发现葡萄糖不耐受患者的努力一致。目的:本研究的目的是确定医院员工中肥胖和未发现的葡萄糖耐受不良的患病率，并评估血糖水平、一些肥胖指标和血压之间的关系。这家医院从来没有进行过这样的研究，它给了员工一个机会，让他们了解肥胖和糖尿病的威胁。材料与方法:筛选工作经医院管理层伦理考虑后批准。获得每位参与者的同意，然后测量一些人体测量指标和餐后2小时血糖水平。将数据输入到Microsoft Excel中，然后使用IBM Statistical Package for the Social Sciences (SPSS)软件第23版进行分析。结果:以体重指数、腰围和腰高比为标准的肥胖率分别为17.4%、33.7%和55.8%，以女性多见。既往未确诊的葡萄糖耐受不良患病率为12.7%(糖耐量受损[IGT]为11.5%，糖尿病为1.2%)，其中女性和男性的比例分别为12.5%和11.9%。结论:虽然未发现的糖尿病患病率较低，但肥胖和IGT患病率较高，提示糖尿病人群处于低患病率向高患病率过渡的阶段。此外，与男性受试者相比，肥胖和葡萄糖耐受不良在女性受试者中更为常见。
{"title":"Screening for obesity and undiscovered glucose intolerance among employees of a tertiary health center in northeast Nigeria","authors":"Y. Lawal, Sanusi Muhammad, U. Dahuwa, I. Bichi, Hayat Ahmed","doi":"10.4103/jhrr.jhrr_44_19","DOIUrl":"https://doi.org/10.4103/jhrr.jhrr_44_19","url":null,"abstract":"Background: The prevalence of type 2 diabetes is increasing worldwide, and according to the International Diabetes Federation, one in every two i.e. 212 million people with diabetes is undiagnosed. This screening exercise was carried out during the World Diabetes Day celebration in line with global efforts toward early detection of persons with glucose intolerance. Aim: The aim of this study was to determine the prevalence of obesity and undiscovered glucose intolerance among the hospital employees and to assess the relationship among blood glucose level, some obesity indices, and blood pressure. No such study was ever carried out in this hospital and it afforded the employees the opportunity to get enlightened about the menace of obesity and diabetes. Materials and Methods: The screening exercise was approved by the hospital management after due ethical consideration. Consent was obtained from each participant and then some anthropometric indices and 2-h postprandial plasma glucose level were measured. Data were entered into Microsoft Excel, and then analyzed using IBM Statistical Package for the Social Sciences (SPSS) software, version 23. Results: The prevalence of obesity by body mass index, waist circumference, and waist-height ratio criteria was 17.4%, 33.7%, and 55.8%, respectively, and was more common among females. The prevalence of previously undiagnosed glucose intolerance was 12.7% (impaired glucose tolerance [IGT], 11.5% and diabetes mellitus, 1.2%) and the proportion among females and males was 12.5% and 11.9%, respectively. Conclusion: Though the prevalence of undiscovered diabetes was low, the prevalence of obesity and IGT was high, suggesting a population in transition from low prevalence to high prevalence of diabetes. In addition, obesity and glucose intolerance were more common among female compared to those among male participants.","PeriodicalId":16068,"journal":{"name":"Journal of Health Research and Reviews","volume":"24 1","pages":"107 - 113"},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79426026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Muazu, Rifkatu Mshelia, H. Bako, M. Ahmad, Tasiu Mohammed, I. Okpe, A. Bakari
Background: Metabolic syndrome (MS) is a cluster of the most dangerous risk factors for heart attack, is associated with unhealthy lifestyle practices brought about by modernization of societies, and is thought to be uncommon in developing nations, especially in rural setting, hence we intend to document its prevalence and associated factors. Materials and Methods: A cross-sectional community-based study involved 362 apparently healthy consenting adults, aged 18–72 years (males, 197 and females, 165) who met the inclusion criteria. Structured questionnaire was used to generate data and physicals were carried out, including anthropometry using the World Health Organization Stepwise protocol. Fasting blood sample was taken for determination of serum lipid profiles and glucose. International Diabetes Federation ethnic-specific criteria for the diagnosis of MS were used. The Statistical Package for the Social Sciences (SPSS) (version 23) software was used for the analysis with P < 0.05. Results: The mean age was 30.2 (9.4) years. A prevalence of MS was found to be 8.8%. Female/male ratio was 15.1%:3.6%, P = 0.003, 40–49 years age group (37.5%) was the most common age group, and 19.8% of all subjects were overweight. The most common recurring components in the diagnosis of MS were reduced high-density lipoprotein cholesterol (HDL-C) (87.5%), raised fasting blood glucose (56.3%), and high systolic blood pressure (46.9%). Regression analysis revealed that being diabetic/hypertensive, family history of hypertension/diabetes mellitus, total cholesterol, and increasing age were found to be associated with MS. Conclusion: The prevalence of MS in this community was 8.8%, more common in females and 40–49 years age group, and was largely determined by the contribution of low levels of HDL-C but not hypertriglyceridemia. Independent predictors of MS were found to be family history of hypertension, raised total cholesterol, and increasing age.
{"title":"Metabolic syndrome and its associated factors among apparently “healthy” adults residing in rural settlements in Dutse, Northwestern Nigeria: A community-based study","authors":"S. Muazu, Rifkatu Mshelia, H. Bako, M. Ahmad, Tasiu Mohammed, I. Okpe, A. Bakari","doi":"10.4103/jhrr.jhrr_37_19","DOIUrl":"https://doi.org/10.4103/jhrr.jhrr_37_19","url":null,"abstract":"Background: Metabolic syndrome (MS) is a cluster of the most dangerous risk factors for heart attack, is associated with unhealthy lifestyle practices brought about by modernization of societies, and is thought to be uncommon in developing nations, especially in rural setting, hence we intend to document its prevalence and associated factors. Materials and Methods: A cross-sectional community-based study involved 362 apparently healthy consenting adults, aged 18–72 years (males, 197 and females, 165) who met the inclusion criteria. Structured questionnaire was used to generate data and physicals were carried out, including anthropometry using the World Health Organization Stepwise protocol. Fasting blood sample was taken for determination of serum lipid profiles and glucose. International Diabetes Federation ethnic-specific criteria for the diagnosis of MS were used. The Statistical Package for the Social Sciences (SPSS) (version 23) software was used for the analysis with P < 0.05. Results: The mean age was 30.2 (9.4) years. A prevalence of MS was found to be 8.8%. Female/male ratio was 15.1%:3.6%, P = 0.003, 40–49 years age group (37.5%) was the most common age group, and 19.8% of all subjects were overweight. The most common recurring components in the diagnosis of MS were reduced high-density lipoprotein cholesterol (HDL-C) (87.5%), raised fasting blood glucose (56.3%), and high systolic blood pressure (46.9%). Regression analysis revealed that being diabetic/hypertensive, family history of hypertension/diabetes mellitus, total cholesterol, and increasing age were found to be associated with MS. Conclusion: The prevalence of MS in this community was 8.8%, more common in females and 40–49 years age group, and was largely determined by the contribution of low levels of HDL-C but not hypertriglyceridemia. Independent predictors of MS were found to be family history of hypertension, raised total cholesterol, and increasing age.","PeriodicalId":16068,"journal":{"name":"Journal of Health Research and Reviews","volume":"35 1","pages":"95 - 101"},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87235991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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