Maitri Mahant, Sweta B. Besh, Divya Kanojiya, Cyril Sajan, Hemrajsingh Rajput, Rajesh A. Maheshwari
Osteoporosis is a widespread concern that poses significant health risks. In the past, it was commonly thought that women would naturally undergo this condition as they age, especially during menopause when hormonal imbalances heighten the risk. Osteoporotic fractures affect approximately one in three women and one in five men over the age of 50 during their lifetimes. The mature skeleton constantly undergoes a remodelling process that involves both bone formation and resorption. However, when bone resorption exceeds bone growth, osteoporosis develops. Both men and women need to prioritize their bone health throughout their lives. Addressing factors that impact bone health at every stage becomes crucial in preventing osteoporosis. To combat the rising incidence of osteoporotic fractures, it is crucial to implement effective preventive measures aimed at maximizing peak bone density, limiting accelerated bone loss, and reducing the risk of falls. Present therapy goals primarily focus on stopping further bone loss and fractures, preserving bone mass, and utilizing medications like bisphosphonates, Selective Estrogen Receptor Modulators (SERMs), anabolic steroids, strontium, and Hormonal Replacement Therapy (HRT). However, it’s worth noting that some of these treatments, such as HRT, bisphosphonates, SERMs, and anabolic steroids, may have negative side effects. As a result, there is an urgent need to identify effective, affordable, natural, and less harmful compounds to manage osteopenia/osteoporosis effectively. The search for safer alternatives is crucial in combating this condition and promoting better bone health.
{"title":"Herbal Remedies for Osteoporosis","authors":"Maitri Mahant, Sweta B. Besh, Divya Kanojiya, Cyril Sajan, Hemrajsingh Rajput, Rajesh A. Maheshwari","doi":"10.18311/jnr/2023/34056","DOIUrl":"https://doi.org/10.18311/jnr/2023/34056","url":null,"abstract":"Osteoporosis is a widespread concern that poses significant health risks. In the past, it was commonly thought that women would naturally undergo this condition as they age, especially during menopause when hormonal imbalances heighten the risk. Osteoporotic fractures affect approximately one in three women and one in five men over the age of 50 during their lifetimes. The mature skeleton constantly undergoes a remodelling process that involves both bone formation and resorption. However, when bone resorption exceeds bone growth, osteoporosis develops. Both men and women need to prioritize their bone health throughout their lives. Addressing factors that impact bone health at every stage becomes crucial in preventing osteoporosis. To combat the rising incidence of osteoporotic fractures, it is crucial to implement effective preventive measures aimed at maximizing peak bone density, limiting accelerated bone loss, and reducing the risk of falls. Present therapy goals primarily focus on stopping further bone loss and fractures, preserving bone mass, and utilizing medications like bisphosphonates, Selective Estrogen Receptor Modulators (SERMs), anabolic steroids, strontium, and Hormonal Replacement Therapy (HRT). However, it’s worth noting that some of these treatments, such as HRT, bisphosphonates, SERMs, and anabolic steroids, may have negative side effects. As a result, there is an urgent need to identify effective, affordable, natural, and less harmful compounds to manage osteopenia/osteoporosis effectively. The search for safer alternatives is crucial in combating this condition and promoting better bone health.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"16 2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135874106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Prostatis prevalence more in aged males and amidst disputes of severe therapeutic measures, both physicians and patients resort to alternative and non-traditional measures. The aim of this study is to investigate the effect of Musa paradisiaca (lyophilized juice) and Punica granatum (peel powder) suspension by carrageenan-induced method for prostatitis in Sprague Dawley rats. Suspension of Musa paradisiaca (lyophilized juice) and Punica granatum (peel powder) were prepared in equal proportion with high dose (400 mg/kg) and low dose (200 mg/kg) after carrageenan induction for one week. The body weight variation, urine volume analysis, white blood cell count in blood, net weight of the prostate gland and histopathological analysis were the parameters assessed. Punica granatum shows a significant increase in body weight, Prostate gland weight and white blood cell count and a decrease in urine volume in the prostatitis-induced control group animals. In Musa paradisiaca, a decrease in body weight, an increase in the prostate gland, white blood cell count and weight in urine volume was observed. The histopathological report evidence that the presence of leukocytes infiltration, papillary fronds were present and an increase in epithelial height was observed in the carrageenan-induced control group. It has been concluded that the low dose suspension of Musa granatum in 200 mg/kg has given a significantly better amelioration effect than compared to other intervention groups.
{"title":"Study on Formulation, Standardization of Herbal Suspension Containing <i>Musa granatum</i> and its Efficacy against Carrageenan Induced Prostatitis in Rodent Model","authors":"Harini Rajendran, Sumithra Mohan, Chitra Velpandian, Prerna Dubey","doi":"10.18311/jnr/2023/34095","DOIUrl":"https://doi.org/10.18311/jnr/2023/34095","url":null,"abstract":"Prostatis prevalence more in aged males and amidst disputes of severe therapeutic measures, both physicians and patients resort to alternative and non-traditional measures. The aim of this study is to investigate the effect of Musa paradisiaca (lyophilized juice) and Punica granatum (peel powder) suspension by carrageenan-induced method for prostatitis in Sprague Dawley rats. Suspension of Musa paradisiaca (lyophilized juice) and Punica granatum (peel powder) were prepared in equal proportion with high dose (400 mg/kg) and low dose (200 mg/kg) after carrageenan induction for one week. The body weight variation, urine volume analysis, white blood cell count in blood, net weight of the prostate gland and histopathological analysis were the parameters assessed. Punica granatum shows a significant increase in body weight, Prostate gland weight and white blood cell count and a decrease in urine volume in the prostatitis-induced control group animals. In Musa paradisiaca, a decrease in body weight, an increase in the prostate gland, white blood cell count and weight in urine volume was observed. The histopathological report evidence that the presence of leukocytes infiltration, papillary fronds were present and an increase in epithelial height was observed in the carrageenan-induced control group. It has been concluded that the low dose suspension of Musa granatum in 200 mg/kg has given a significantly better amelioration effect than compared to other intervention groups.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"14 11","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135875301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Citrus aurantium (Thurunji) is a tree cultivated in various parts of the world. The fruit pulp is used to make juices, marmalade and pickles. It is commonly used by tribes to treat digestive disorders, constipation, heaviness in the chest, prolapse of the uterus, anorexia, chest pain, cold, and cough. In the Siddha system of medicine, Citrus aurantium fruit pulp is used to prepare a formulation, syrup in consistency named Thurunji manapaagu indicated for diseases due to deranged pitha humor. According to the Siddha system of medicine Hypertension termed Uratha Pitha Vatham is an ailment that occurs due to an elevated pitham. Considering the facts an attempt of in silico docking study was done with the selected phytochemicals such as Linalool, Apigenin, Ichangin, Kaempferol, Luteolin, Limonin, Limonene, Myrcene, Diosmetin and Tangeretin of Citrus aurantium against Angiotensin Converting Enzyme (ACE) and the results are detailed in this article.
{"title":"In Silico Computational Analysis of <i>Citrus aurantium</i> of <i>Thurunji manapagu</i> in Inhibiting the Receptor Target of Angiotensin-converting Enzyme Against <i>Uratha Pitha Vatham</i> (Hypertension)","authors":"Radha Sudalaimani, Swathi Thangapandiyan, Mariappan Andi, Sivakumar Shantiarappa Udayar, Meenakumari Ramasamy","doi":"10.18311/jnr/2023/32916","DOIUrl":"https://doi.org/10.18311/jnr/2023/32916","url":null,"abstract":"Citrus aurantium (Thurunji) is a tree cultivated in various parts of the world. The fruit pulp is used to make juices, marmalade and pickles. It is commonly used by tribes to treat digestive disorders, constipation, heaviness in the chest, prolapse of the uterus, anorexia, chest pain, cold, and cough. In the Siddha system of medicine, Citrus aurantium fruit pulp is used to prepare a formulation, syrup in consistency named Thurunji manapaagu indicated for diseases due to deranged pitha humor. According to the Siddha system of medicine Hypertension termed Uratha Pitha Vatham is an ailment that occurs due to an elevated pitham. Considering the facts an attempt of in silico docking study was done with the selected phytochemicals such as Linalool, Apigenin, Ichangin, Kaempferol, Luteolin, Limonin, Limonene, Myrcene, Diosmetin and Tangeretin of Citrus aurantium against Angiotensin Converting Enzyme (ACE) and the results are detailed in this article.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"16 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135874105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The concept of substitution, as Pratinidhidravya, is profound in the Indian traditional medicinal system, the Ayurveda. This science of life mode of holistic medication has been practiced for ages. With the dilution of knowledge in the post-Vedic era and with the discrepancies in documentation processes of several medicinal drugs, there exist tremendous needs to validate the scientific study of substitutes that are mentioned in various standard Ayurvedic references. In addition to government efforts to standardize the drug, it certainly falls into the responsibility and jurisdiction of every herbal scientist and Ayurvedic practitioner to collaborate and rejuvenate this marvelous medicinal goldmine. Often, orchids are very much praised for their medicinal value in Ayurveda, and several genera are used in various forms regularly. However, due to mainly over-exploitation, often the original drug is substituted by some either related or unrelated drugs. This review aims to elaborate and, in turn, understand the need, authenticity, and scientific appropriateness of certain herbs which are used to substitute Orchids in Ayurveda. A global and standardized approach is needed to understand the need and process of substituting a particular drug in both monoherbal and polyherbal formulations, in order to develop a potent medication for certain diseases.
{"title":"Use of Orchids in <i>Ayurveda</i>: Is Substitution Scientific and Appropriate?","authors":"Sourav Mukherjee, Ninad Nangare, Suresh Jagtap","doi":"10.18311/jnr/2023/31375","DOIUrl":"https://doi.org/10.18311/jnr/2023/31375","url":null,"abstract":"The concept of substitution, as Pratinidhidravya, is profound in the Indian traditional medicinal system, the Ayurveda. This science of life mode of holistic medication has been practiced for ages. With the dilution of knowledge in the post-Vedic era and with the discrepancies in documentation processes of several medicinal drugs, there exist tremendous needs to validate the scientific study of substitutes that are mentioned in various standard Ayurvedic references. In addition to government efforts to standardize the drug, it certainly falls into the responsibility and jurisdiction of every herbal scientist and Ayurvedic practitioner to collaborate and rejuvenate this marvelous medicinal goldmine. Often, orchids are very much praised for their medicinal value in Ayurveda, and several genera are used in various forms regularly. However, due to mainly over-exploitation, often the original drug is substituted by some either related or unrelated drugs. This review aims to elaborate and, in turn, understand the need, authenticity, and scientific appropriateness of certain herbs which are used to substitute Orchids in Ayurveda. A global and standardized approach is needed to understand the need and process of substituting a particular drug in both monoherbal and polyherbal formulations, in order to develop a potent medication for certain diseases.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135874107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: This study aimed to compare the effectiveness of aromatherapy massage with ginger and sesame oil on joint pain and stiffness in patients with knee joint osteoarthritis. Methods: This study was performed as a single-blind randomized clinical trial. Ninety patients with osteoarthritis were selected via convenience sampling from patients referring to rheumatology clinics affiliated with Birjand University of Medical Sciences. The subjects were randomly assigned into three groups: massage with oils ginger and sesame, and a control group (no massage). Symptoms were assessed using the Western Ontario McMaster Universities Arthritis Scale (WOMAC) index at baseline at three stages after the intervention (immediately, two weeks, and four weeks). Data analysis was performed with SPSS19 using Chisquare, Friedman and Kruskal-Wallis tests. Results: The findings of the study revealed that the mean pain scores in the ginger and sesame oil groups had a decreasing course before and immediately after the intervention compared to 2 weeks after the intervention. However, the changes in mean score showed an increase again 4 weeks after the intervention (P<0.001). The mean score of joint stiffness in the ginger group suggested a decreasing course before intervention compared to immediately after and two weeks after intervention but showed an increase in changes in the mean score four weeks after intervention (P<0.001). Moreover, the mean score of joint stiffness showed a decreasing course in the sesame group before intervention compared to immediately after intervention but showed an increase in the mean score again two weeks and four weeks after intervention (P<0.001). Conclusions: The results of this study demonstrated that aromatherapy massage with ginger and sesame oils are both effective in improving joint pain and stiffness in patients with osteoarthritis; nonetheless, ginger is more effective in improving joint stiffness in patients with osteoarthritis. Moreover, ginger oil is more stable than sesame oil.
{"title":"Comparison of the Effectiveness of Aromatherapy Massage with Ginger and Sesame Oil on Joint Pain and Stiffness in Patients with Knee Osteoarthritis: A Randomized Controlled Clinical Trial","authors":"Ahmad Nasiri Forg, Somayeh Hayati, Rezvaneh Manzour, Azam Saedikia, Nahid Salehi Mashhad Taraghi, Elham Atabati","doi":"10.18311/jnr/2023/32206","DOIUrl":"https://doi.org/10.18311/jnr/2023/32206","url":null,"abstract":"Background: This study aimed to compare the effectiveness of aromatherapy massage with ginger and sesame oil on joint pain and stiffness in patients with knee joint osteoarthritis. Methods: This study was performed as a single-blind randomized clinical trial. Ninety patients with osteoarthritis were selected via convenience sampling from patients referring to rheumatology clinics affiliated with Birjand University of Medical Sciences. The subjects were randomly assigned into three groups: massage with oils ginger and sesame, and a control group (no massage). Symptoms were assessed using the Western Ontario McMaster Universities Arthritis Scale (WOMAC) index at baseline at three stages after the intervention (immediately, two weeks, and four weeks). Data analysis was performed with SPSS19 using Chisquare, Friedman and Kruskal-Wallis tests. Results: The findings of the study revealed that the mean pain scores in the ginger and sesame oil groups had a decreasing course before and immediately after the intervention compared to 2 weeks after the intervention. However, the changes in mean score showed an increase again 4 weeks after the intervention (P<0.001). The mean score of joint stiffness in the ginger group suggested a decreasing course before intervention compared to immediately after and two weeks after intervention but showed an increase in changes in the mean score four weeks after intervention (P<0.001). Moreover, the mean score of joint stiffness showed a decreasing course in the sesame group before intervention compared to immediately after intervention but showed an increase in the mean score again two weeks and four weeks after intervention (P<0.001). Conclusions: The results of this study demonstrated that aromatherapy massage with ginger and sesame oils are both effective in improving joint pain and stiffness in patients with osteoarthritis; nonetheless, ginger is more effective in improving joint stiffness in patients with osteoarthritis. Moreover, ginger oil is more stable than sesame oil.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"16 22","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135874230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bharat Rathi, Renu Rathi, Mujahid Khan, Swapnali Khabade
In Ayurveda pharmaceutics, herbal drugs, minerals, metals, and gems are used as raw materials. Most of the minerals and metals are obtained from the mines and hence there is every chance of impurities and heterogeneous qualities due to the mixing of various substances and impurities. Hence these minerals and metals have to undergo various samskaras (processes) before being converted into medicines from raw states and then subsequent use for internal administration. Due to these processes, the natural qualities of the drugs get modified and converted into new therapeutic properties. The present study is planned to identify some important processes of Rasashastra (Indian alchemy) and their impact on the physical, chemical and therapeutic properties of the final product. Conversion of a raw drug into medicinal form has a mammoth impact such as palatability, increased shelf life, feasibility during travelling, maintaining accurate dosing and ease of administration. Shodhana (detoxification) brings out physical, chemical and biological changes in the drug. Wet trituration modifies the analytical parameters of the drug which in turn facilitates the absorption process. Due to maranaa (incineration), toxic effects are nullified and drugs become therapeutically more effective. Thus, various processes described in Rasashastra show multidimensional pharmaceutical and therapeutical implications in Ayurvedic pharmaceutics.
{"title":"Impact of Various Processes (<i>Samskara</i>) in Ayurvedic Pharmaceutics","authors":"Bharat Rathi, Renu Rathi, Mujahid Khan, Swapnali Khabade","doi":"10.18311/jnr/2023/29987","DOIUrl":"https://doi.org/10.18311/jnr/2023/29987","url":null,"abstract":"In Ayurveda pharmaceutics, herbal drugs, minerals, metals, and gems are used as raw materials. Most of the minerals and metals are obtained from the mines and hence there is every chance of impurities and heterogeneous qualities due to the mixing of various substances and impurities. Hence these minerals and metals have to undergo various samskaras (processes) before being converted into medicines from raw states and then subsequent use for internal administration. Due to these processes, the natural qualities of the drugs get modified and converted into new therapeutic properties. The present study is planned to identify some important processes of Rasashastra (Indian alchemy) and their impact on the physical, chemical and therapeutic properties of the final product. Conversion of a raw drug into medicinal form has a mammoth impact such as palatability, increased shelf life, feasibility during travelling, maintaining accurate dosing and ease of administration. Shodhana (detoxification) brings out physical, chemical and biological changes in the drug. Wet trituration modifies the analytical parameters of the drug which in turn facilitates the absorption process. Due to maranaa (incineration), toxic effects are nullified and drugs become therapeutically more effective. Thus, various processes described in Rasashastra show multidimensional pharmaceutical and therapeutical implications in Ayurvedic pharmaceutics.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"14 12","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135875300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A common condition that puts a huge financial and morbidity burden is kidney stones. Throughout the past 20 years, the frequency of urolithiasis has increased; 5 to 15 % of people globally are affected. Calcium oxalate (CaOx) kidney stones, which form in the renal surfaces, are the most prevalent variety. Several physicochemical processes of urinary stone constituents within tubular cells lead to the complex process of stone generation. Obese people are known to be at an increased risk of developing stones. Nephrolithiasis in women is becoming more common because of metabolic syndrome. Recent years have seen a significant change in the detection and initial treatment of urolithiasis. Calcium oxalate renal stones are the most typical type of stone proclaimed in India. Since medicinal herbs are safer, more efficient, more acceptable culturally, and have fewer side effects than produced pharmaceuticals, they have been used for treatment for millennia. Patients are recommended to follow a low-fat diet and take herbal remedies in addition to fibre from naturally occurring plants. Flavonoids are a type of plant polyphenol that has been linked to several health benefits. Recent research has revealed that plant flavonoids can significantly reduce the formation of kidney stones in vitro and in vivo, which correlates with their anti-inflammatory, antioxidant, diuretic, antibacterial, and other beneficial actions. Thus, the flavonoids or extracts of flavonoid-rich plants associated with anti-urolithiasis activity were evaluated. This article emphasises the use of flavonoid-containing plants or herbs and synthetic medications to cure kidney stones. The epidemiology, mechanism of action, pathophysiology, synthetic and natural treatments for kidney stone development, and ways to reduce stone risks are all covered in this review article.
{"title":"Role of Flavonoids in the Treatment of Urolithiasis: A Challenging Herbal Approach","authors":"None Neha, Avijit Mazumder, Saumya Das, Shobhini Chandel","doi":"10.18311/jnr/2023/33996","DOIUrl":"https://doi.org/10.18311/jnr/2023/33996","url":null,"abstract":"A common condition that puts a huge financial and morbidity burden is kidney stones. Throughout the past 20 years, the frequency of urolithiasis has increased; 5 to 15 % of people globally are affected. Calcium oxalate (CaOx) kidney stones, which form in the renal surfaces, are the most prevalent variety. Several physicochemical processes of urinary stone constituents within tubular cells lead to the complex process of stone generation. Obese people are known to be at an increased risk of developing stones. Nephrolithiasis in women is becoming more common because of metabolic syndrome. Recent years have seen a significant change in the detection and initial treatment of urolithiasis. Calcium oxalate renal stones are the most typical type of stone proclaimed in India. Since medicinal herbs are safer, more efficient, more acceptable culturally, and have fewer side effects than produced pharmaceuticals, they have been used for treatment for millennia. Patients are recommended to follow a low-fat diet and take herbal remedies in addition to fibre from naturally occurring plants. Flavonoids are a type of plant polyphenol that has been linked to several health benefits. Recent research has revealed that plant flavonoids can significantly reduce the formation of kidney stones in vitro and in vivo, which correlates with their anti-inflammatory, antioxidant, diuretic, antibacterial, and other beneficial actions. Thus, the flavonoids or extracts of flavonoid-rich plants associated with anti-urolithiasis activity were evaluated. This article emphasises the use of flavonoid-containing plants or herbs and synthetic medications to cure kidney stones. The epidemiology, mechanism of action, pathophysiology, synthetic and natural treatments for kidney stone development, and ways to reduce stone risks are all covered in this review article.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"3 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136018318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
P. Parvathy, G. S. Lekha, S. Aparna, A. Kanagarajan
Diabetic Nephropathy (DN) is a severe kidney illness that presents with proteinuria, enlarged glomeruli, reduction in the process of glomerular filtration, and fibrosis of the kidneys. Approximately one-third of all instances of diabetes globally are brought to diabetic nephropathy, a common cause of end-stage kidney disease. In Siddha’s literature, the complications of Diabetes mellitus were expressed as ten Avathaigal in the Neerizhivu noi chapter. The feature of Avathaigal 1 to 7 depicts some of the clinical outcomes of Diabetic Nephropathy. The manifestation of clinical features in final stage Diabetic Nephropathy includes oliguria, fatigue, anorexia, nausea, vomiting, itching and dryness of skin, drowsiness, numbness and swelling in the limbs, muscle twitching or cramps, bone pain, breathlessness, increased thirst, sleep disturbance, and sexual problems. Oxidative stress is the standard mechanism involved in developing diabetic kidney disease. Most of the Siddha medicines used for managing diabetic Nephropathy are herbal formulations, and they protect against damage to the renal tubules due to their significant antioxidant property. This review summarizes the pathophysiology of Diabetic Nephropathy and the evidence for using Siddha herbal formulations to treat diabetic Nephropathy. For treating early-stage diabetic Nephropathy, Siddha practices primarily emphasize using herbal formulations; however, yoga therapy, diet, and other exercises are also included in Siddha treatment modalities.
{"title":"<i>Siddha</i> Therapeutic Approach to Diabetic Nephropathy – A Review","authors":"P. Parvathy, G. S. Lekha, S. Aparna, A. Kanagarajan","doi":"10.18311/jnr/2023/33881","DOIUrl":"https://doi.org/10.18311/jnr/2023/33881","url":null,"abstract":"Diabetic Nephropathy (DN) is a severe kidney illness that presents with proteinuria, enlarged glomeruli, reduction in the process of glomerular filtration, and fibrosis of the kidneys. Approximately one-third of all instances of diabetes globally are brought to diabetic nephropathy, a common cause of end-stage kidney disease. In Siddha’s literature, the complications of Diabetes mellitus were expressed as ten Avathaigal in the Neerizhivu noi chapter. The feature of Avathaigal 1 to 7 depicts some of the clinical outcomes of Diabetic Nephropathy. The manifestation of clinical features in final stage Diabetic Nephropathy includes oliguria, fatigue, anorexia, nausea, vomiting, itching and dryness of skin, drowsiness, numbness and swelling in the limbs, muscle twitching or cramps, bone pain, breathlessness, increased thirst, sleep disturbance, and sexual problems. Oxidative stress is the standard mechanism involved in developing diabetic kidney disease. Most of the Siddha medicines used for managing diabetic Nephropathy are herbal formulations, and they protect against damage to the renal tubules due to their significant antioxidant property. This review summarizes the pathophysiology of Diabetic Nephropathy and the evidence for using Siddha herbal formulations to treat diabetic Nephropathy. For treating early-stage diabetic Nephropathy, Siddha practices primarily emphasize using herbal formulations; however, yoga therapy, diet, and other exercises are also included in Siddha treatment modalities.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"1 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136018176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sweta B. Besh, Maitri Mahant, Divya Kanojiya, Sapana Patil, Rajesh A. Maheshwari
Chronic, persistent and incapacitating autoimmune ailments known as Rheumatoid Arthritis (RA) are marked by cartilage and bone damage surrounding the joints as well as systemic inflammation of the joints. The fact that 75% of RA patients are female points to the significance of hormones in the etiology of the condition. Synovial membrane inflammation involves mechanisms in the form of genetic, environmental, including immunologic variables that are believed to have a role in its pathogenic mechanism. When it comes to treating RA, the focus has shifted from relieving symptoms to implementing therapeutic regimens that affect the disease’s activity and eventually have been found to halt or stop structural joint destruction. Salicylates, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), corticosteroids, and Disease Modifying Anti-Rheumatic Drugs (DMARDs), Methotrexate (MTX), as well as biologic response enhancers, are some examples of drugs. However, it has negative effects which need to be overcome. It is required to employ herbs and a variety of plants to treat joint pain and inflammation. There are numerous plants with medicinal properties that have been clinically demonstrated to have anti-rheumatoid arthritis effects. As a result, plants and their derivatives with significant benefits are being used for the management of rheumatoid arthritis. The current assessment focuses on medicinal plants that have anti-rheumatoid arthritis efficacy.
{"title":"Plants Used in the Treatment of Rheumatoid Arthritis","authors":"Sweta B. Besh, Maitri Mahant, Divya Kanojiya, Sapana Patil, Rajesh A. Maheshwari","doi":"10.18311/jnr/2023/34055","DOIUrl":"https://doi.org/10.18311/jnr/2023/34055","url":null,"abstract":"Chronic, persistent and incapacitating autoimmune ailments known as Rheumatoid Arthritis (RA) are marked by cartilage and bone damage surrounding the joints as well as systemic inflammation of the joints. The fact that 75% of RA patients are female points to the significance of hormones in the etiology of the condition. Synovial membrane inflammation involves mechanisms in the form of genetic, environmental, including immunologic variables that are believed to have a role in its pathogenic mechanism. When it comes to treating RA, the focus has shifted from relieving symptoms to implementing therapeutic regimens that affect the disease’s activity and eventually have been found to halt or stop structural joint destruction. Salicylates, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), corticosteroids, and Disease Modifying Anti-Rheumatic Drugs (DMARDs), Methotrexate (MTX), as well as biologic response enhancers, are some examples of drugs. However, it has negative effects which need to be overcome. It is required to employ herbs and a variety of plants to treat joint pain and inflammation. There are numerous plants with medicinal properties that have been clinically demonstrated to have anti-rheumatoid arthritis effects. As a result, plants and their derivatives with significant benefits are being used for the management of rheumatoid arthritis. The current assessment focuses on medicinal plants that have anti-rheumatoid arthritis efficacy.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"1 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136018177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C. Kalaiarasi, R. Keerthika, D. Periyasami, N. J. Muthukumar
Anterior cruciate ligament rupture is one of the most common musculo-skeletal injuries in active individuals, especially athletes. Varmam treatment, as part of the Siddha, primarily treats traumatic injuries. A 25-year-old female patient came to Varma Maruthuvam OPD, National Institute of Siddha, Chennai, with complaints of severe right knee joint pain, swelling, walking difficulty, instability while walking, and difficulty in flexion and extension of the right knee joint for 10 days. Initially, she consulted an allopathic hospital, and after her MRI was done, she was diagnosed with an anterior cruciate ligament tear grade II and advised for surgery. The patient refused to go for surgery and came to our OPD for further management. She was treated with Siddha Varmam therapy and external medicine, Murivu ennai, for 50 days and followed up for four months. The ligament tear healed without any surgical treatment, and the patient returned to her regular work, which was assessed by a visual analogue scale. This case report summarizes the conservative management of an anterior cruciate ligament tear grade II by Siddha Varmam therapy.
{"title":"Siddha <i>Varmam</i> Therapy in the Management of Anterior Cruciate Ligament Tear Grade II - A Case Report","authors":"C. Kalaiarasi, R. Keerthika, D. Periyasami, N. J. Muthukumar","doi":"10.18311/jnr/2023/33561","DOIUrl":"https://doi.org/10.18311/jnr/2023/33561","url":null,"abstract":"Anterior cruciate ligament rupture is one of the most common musculo-skeletal injuries in active individuals, especially athletes. Varmam treatment, as part of the Siddha, primarily treats traumatic injuries. A 25-year-old female patient came to Varma Maruthuvam OPD, National Institute of Siddha, Chennai, with complaints of severe right knee joint pain, swelling, walking difficulty, instability while walking, and difficulty in flexion and extension of the right knee joint for 10 days. Initially, she consulted an allopathic hospital, and after her MRI was done, she was diagnosed with an anterior cruciate ligament tear grade II and advised for surgery. The patient refused to go for surgery and came to our OPD for further management. She was treated with Siddha Varmam therapy and external medicine, Murivu ennai, for 50 days and followed up for four months. The ligament tear healed without any surgical treatment, and the patient returned to her regular work, which was assessed by a visual analogue scale. This case report summarizes the conservative management of an anterior cruciate ligament tear grade II by Siddha Varmam therapy.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136018320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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