Sreelakshmi S. Kartha, B. N. Ashwini, K. Sivabalaji
Introduction: Chronic Rhino Sinusitis (CRS) is an inflammatory disease of the nose and sinuses with clinical features such as nasal blockage, nasal discharge and hyposmia. Current treatment modalities are antibiotics, corticosteroids and surgical interventions but the recurrent rate is high. In classics, dushtaprathisyaya features are similar to chronic rhinosinusitis. Materials and Methods: To analyze the effect of pippalyadi avapeeda nasya, elakanadi kashaya and vyoshadi ghrita in reducing the symptoms of chronic rhino sinusitis using nasal signs and symptom score, anterior rhinoscopy, X-ray Para Nasal Sinus (PNS) Waters view and nasal endoscopy. The study discusses the Ayurvedic intervention of 30 cases diagnosed as CRS. Pachana - deepana with astachoorna, snehapana with vyoshadi ghrita and virechana with nimbamritadi eranda taila for kayashodhana followed by shira shodhana with pippalyadi avapeeda nasya. Orally Elakanadi kashaya and vyoshadi ghrita was administered. Results and Discussion: Combined use of sodhana and samana aushadhi showed significant reduction in nasal obstruction, nasal discharge and hyposmia with an improvement of 100, 100 and 56.66 % respectively. Statistical analyses were performed with SPSS software and are clinically significant with p < 0.0001. Conclusion: A combination of kayasodhana and sirasodhana is effective in improving subjective symptoms like nasal blockage, nasal discharge and hyposmia which was evident with anterior rhinoscopy, endoscopy and X-ray PNS Waters view.
{"title":"Clinical Evaluation of <i>Pippalyadi Avapeeda Nasya, Elakanadi Kashaya</i> and <i>Vyoshadi Ghrita</i> in Chronic Rhinosinusitis: Case Series","authors":"Sreelakshmi S. Kartha, B. N. Ashwini, K. Sivabalaji","doi":"10.18311/jnr/2023/28602","DOIUrl":"https://doi.org/10.18311/jnr/2023/28602","url":null,"abstract":"Introduction: Chronic Rhino Sinusitis (CRS) is an inflammatory disease of the nose and sinuses with clinical features such as nasal blockage, nasal discharge and hyposmia. Current treatment modalities are antibiotics, corticosteroids and surgical interventions but the recurrent rate is high. In classics, dushtaprathisyaya features are similar to chronic rhinosinusitis. Materials and Methods: To analyze the effect of pippalyadi avapeeda nasya, elakanadi kashaya and vyoshadi ghrita in reducing the symptoms of chronic rhino sinusitis using nasal signs and symptom score, anterior rhinoscopy, X-ray Para Nasal Sinus (PNS) Waters view and nasal endoscopy. The study discusses the Ayurvedic intervention of 30 cases diagnosed as CRS. Pachana - deepana with astachoorna, snehapana with vyoshadi ghrita and virechana with nimbamritadi eranda taila for kayashodhana followed by shira shodhana with pippalyadi avapeeda nasya. Orally Elakanadi kashaya and vyoshadi ghrita was administered. Results and Discussion: Combined use of sodhana and samana aushadhi showed significant reduction in nasal obstruction, nasal discharge and hyposmia with an improvement of 100, 100 and 56.66 % respectively. Statistical analyses were performed with SPSS software and are clinically significant with p < 0.0001. Conclusion: A combination of kayasodhana and sirasodhana is effective in improving subjective symptoms like nasal blockage, nasal discharge and hyposmia which was evident with anterior rhinoscopy, endoscopy and X-ray PNS Waters view.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"52 s40","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135430930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Indigenous people depend on nature for their livelihood. They are reliant on nearby forest flora and animals for food, medicines, and building materials for their homes. The first tribes had their own in-depth knowledge and answers for all elements of existence. Tribal wisdom has always been transmitted orally from one generation to the next. This tribal wisdom includes knowledge about the plants and herbs and their medicinal values and uses. Myths and legends play a major role in carrying that information with them from generation to generation. Native American and Indian tribal communities have always had a variety of medical procedures and supplies having a long history of usage are referred to as traditional medicine. Out of the different herbs and plants, sweet grass from Native Americans and Durva or Doob grass from Indians has a noteworthy importance and connection to their respective cultures. To highlight the parallels in the two grasses’ purpose and significance, this article attempts to create a comparison analysis between them. While bringing out their similarities, the native American and Indian tribal likeness in culture and practices is also studied.
{"title":"Mythology and Medicine: A Comparative Study of Native American’s Sweet Grass and Indian’s <i>Durva</i> Grass","authors":"V. Harini, Sonu Joseph","doi":"10.18311/jnr/2023/34180","DOIUrl":"https://doi.org/10.18311/jnr/2023/34180","url":null,"abstract":"Indigenous people depend on nature for their livelihood. They are reliant on nearby forest flora and animals for food, medicines, and building materials for their homes. The first tribes had their own in-depth knowledge and answers for all elements of existence. Tribal wisdom has always been transmitted orally from one generation to the next. This tribal wisdom includes knowledge about the plants and herbs and their medicinal values and uses. Myths and legends play a major role in carrying that information with them from generation to generation. Native American and Indian tribal communities have always had a variety of medical procedures and supplies having a long history of usage are referred to as traditional medicine. Out of the different herbs and plants, sweet grass from Native Americans and Durva or Doob grass from Indians has a noteworthy importance and connection to their respective cultures. To highlight the parallels in the two grasses’ purpose and significance, this article attempts to create a comparison analysis between them. While bringing out their similarities, the native American and Indian tribal likeness in culture and practices is also studied.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"53 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135431060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lou Gehrig’s disease, commonly known as amyotrophic lateral sclerosis, is an incredibly rare clinical condition that affects about 5 in 100,000 people annually in India, making it one of the rarest diseases in the entire world. With an average age of 55, this disease typically impacts people between the ages of 40 and 70. Males are more prone to develop the condition. Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disorder affecting primarily the motor system, but in which extramotor manifestations are increasingly recognized. The loss of upper and lower motor neurons in the motor cortex, the brain stem nuclei and the anterior horn of the spinal cord gives rise to progressive muscle weakness and wasting. Typically, patients report difficulties swallowing or a shift in voice pitch while speaking due to tongue involvement. Initial ALS symptoms can resemble those of other neuromuscular illnesses and are completely non-specific. In this case report, we described a 44-year-old gentleman who has been diagnosed with Amyotrophic Lateral Sclerosis in accordance to an MRI scan describing symptoms like unable to speak, reduced tongue movements, trouble swallowing, excessive salivation, swelling over the tongue and loss of tongue tone for the past three to four months. The present study discusses the clinical presentation, diagnosis, therapeutic regimen and prognosis. Both allopathic and ayurvedic oral medications with local therapeutic regimens like Jivha Pratisarana (Rubbing of dry powder on tongue) and Nasya (nasal drops of medicated oil) were employed in the patient which have satisfactory results enhancing for betterment of lifestyle.
{"title":"Conventional Remedy to Lou Gehrig’s Disease - Amyotrophic Lateral Sclerosis (ALS): A Rare Clinical Entity","authors":"Deepak Gupta, Mayur Shiralkar, Vaishali Chaudhari","doi":"10.18311/jnr/2023/34259","DOIUrl":"https://doi.org/10.18311/jnr/2023/34259","url":null,"abstract":"Lou Gehrig’s disease, commonly known as amyotrophic lateral sclerosis, is an incredibly rare clinical condition that affects about 5 in 100,000 people annually in India, making it one of the rarest diseases in the entire world. With an average age of 55, this disease typically impacts people between the ages of 40 and 70. Males are more prone to develop the condition. Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disorder affecting primarily the motor system, but in which extramotor manifestations are increasingly recognized. The loss of upper and lower motor neurons in the motor cortex, the brain stem nuclei and the anterior horn of the spinal cord gives rise to progressive muscle weakness and wasting. Typically, patients report difficulties swallowing or a shift in voice pitch while speaking due to tongue involvement. Initial ALS symptoms can resemble those of other neuromuscular illnesses and are completely non-specific. In this case report, we described a 44-year-old gentleman who has been diagnosed with Amyotrophic Lateral Sclerosis in accordance to an MRI scan describing symptoms like unable to speak, reduced tongue movements, trouble swallowing, excessive salivation, swelling over the tongue and loss of tongue tone for the past three to four months. The present study discusses the clinical presentation, diagnosis, therapeutic regimen and prognosis. Both allopathic and ayurvedic oral medications with local therapeutic regimens like Jivha Pratisarana (Rubbing of dry powder on tongue) and Nasya (nasal drops of medicated oil) were employed in the patient which have satisfactory results enhancing for betterment of lifestyle.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135431825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Although standardising polyherbal medicine requires immediate attention, it is a tedious undertaking. Phytochemical profiling is a particularly useful tool for assessing the quality and effectiveness of polyherbal medicines, among various methods used for standardization. The proposal aimed to develop a precise RP-HPLC method for simultaneous estimation of eugenol and scopoletin in in-house Avipattikar churna. This method was also used to estimate scopoletin in various extracts of Ipomoea turpethum. Methods: The phytomarkers in Avipattikar churna, hydroalcoholic and alcoholic extracts of Jalap were estimated by RP-HPLC system. In this setup, RP-ODS C8 column was employed with methanol: water (30:70 v/v, 0.1% formic acid) at 1 ml/min for 0-10 minutes, and then with methanol: water (60:40 v/v) at 0.8 ml/min for 10.01-25 minutes. Detection was done at 280 nm for eugenol and 366 nm for scopoletin using a UV/VIS detector. The method was validated by performing validation parameters as per ICH guidelines. Results: The linearity of eugenol and scopoletin was performed, with correlation coefficients of 0.999 and 0.9969 respectively. In repeatability, % RSD was observed as 0.856 and 0.909 for eugenol and scopoletin correspondingly. The LOD (detection limit) of eugenol was 0.67 μg/mL and of scopoletin was 1.39 μg/mL. While LOQ (quantification limit) of eugenol was found as 2.04 μg/mL and 4.03 μg/mL for scopoletin. The % recovery was ranging from 102.96 - 100.45 % for eugenol and from 102.65 - 101.3 %w/w for scopoletin, after adding a pre-quantified amount (20 μg/mL) in the different concentrations of the standards. The eugenol and scopoletin were estimated 0.1366 %w/w and 0.0465 %w/w respectively in Avipattikar churna. The hydro alcoholic extract of Jalap showed presence of more scopoletin than in the alcoholic extract. Conclusion: The validated process is established as accurate, consistent and precise which results as a better standardization drive for Ayurvedic dosage forms.
{"title":"Simultaneous Estimation of Eugenol and Scopoletin from the in House <i>Avipattikar Churna</i> by RP-HPLC Method and Estimation of Scopoletin from Different Extracts of <i>Jalap</i>","authors":"Priya Shah, Maitreyi Zaveri","doi":"10.18311/jnr/2023/34465","DOIUrl":"https://doi.org/10.18311/jnr/2023/34465","url":null,"abstract":"Background: Although standardising polyherbal medicine requires immediate attention, it is a tedious undertaking. Phytochemical profiling is a particularly useful tool for assessing the quality and effectiveness of polyherbal medicines, among various methods used for standardization. The proposal aimed to develop a precise RP-HPLC method for simultaneous estimation of eugenol and scopoletin in in-house Avipattikar churna. This method was also used to estimate scopoletin in various extracts of Ipomoea turpethum. Methods: The phytomarkers in Avipattikar churna, hydroalcoholic and alcoholic extracts of Jalap were estimated by RP-HPLC system. In this setup, RP-ODS C8 column was employed with methanol: water (30:70 v/v, 0.1% formic acid) at 1 ml/min for 0-10 minutes, and then with methanol: water (60:40 v/v) at 0.8 ml/min for 10.01-25 minutes. Detection was done at 280 nm for eugenol and 366 nm for scopoletin using a UV/VIS detector. The method was validated by performing validation parameters as per ICH guidelines. Results: The linearity of eugenol and scopoletin was performed, with correlation coefficients of 0.999 and 0.9969 respectively. In repeatability, % RSD was observed as 0.856 and 0.909 for eugenol and scopoletin correspondingly. The LOD (detection limit) of eugenol was 0.67 μg/mL and of scopoletin was 1.39 μg/mL. While LOQ (quantification limit) of eugenol was found as 2.04 μg/mL and 4.03 μg/mL for scopoletin. The % recovery was ranging from 102.96 - 100.45 % for eugenol and from 102.65 - 101.3 %w/w for scopoletin, after adding a pre-quantified amount (20 μg/mL) in the different concentrations of the standards. The eugenol and scopoletin were estimated 0.1366 %w/w and 0.0465 %w/w respectively in Avipattikar churna. The hydro alcoholic extract of Jalap showed presence of more scopoletin than in the alcoholic extract. Conclusion: The validated process is established as accurate, consistent and precise which results as a better standardization drive for Ayurvedic dosage forms.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"50 11","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135431829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Shanthi, S. Latha, G. Karthikeyan, P. Jeeva, A. Janani, K. Karthick
Diabetes Mellitus (DM), a significant metabolic disorder that increases mortality and morbidity, affects people all over the world. Recently, many individuals are exploring CAM treatment that may have fewer side effects due to the prominent side effects of allopathic medications. Ziziphus jujuba (L.) Gaertn. (Rhamnaceae) stem bark has been a vital part of the conventional system of medicine for the management of diabetes, inflammation, wounds, fever, asthma and liver disorders. In spite of its pharmacological significance, Ziziphus jujuba stem bark lacks scientific evidence of its antidiabetic and antioxidant potential. Hence, an attempt has been made to evaluate the anti-diabetic effect of the stem bark of Ziziphus jujuba using alpha-amylase inhibition assay. In this research work, we further investigated the antioxidant activity of the Ziziphus jujuba using DPPH and Nitric oxide radical scavenging assay. The Chloroform (CEZJ), ethyl acetate (EAZJ) and Ethanol (EEZJ) extracts of Ziziphus jujuba stem bark were used in the study. In the DPPH radical scavenging assay, EEZJ had an IC50 value of 117.1 µg/ml, however, the value for the nitric oxide scavenging assay was 64.65 µg/ml. The Ziziphus jujuba was additionally examined for its in-vitro antidiabetic potential using an alpha-amylase inhibition assay, and it was discovered to possess a considerable percentage of alpha-amylase inhibition. The IC50 of EEZJ was found to be 34.68 µg/ml. These results imply that the Ziziphus jujuba possesses considerable antioxidant and anti-diabetic properties. To thoroughly establish the anti-diabetic potential of Ziziphus jujuba, additional in vitro experiments utilizing cell lines and other enzymes may be conducted.
{"title":"Evaluation of Antioxidant and Anti-diabetic Activity of Stem Bark of Ziziphus jujuba</i> (L.) Gaertn","authors":"S. Shanthi, S. Latha, G. Karthikeyan, P. Jeeva, A. Janani, K. Karthick","doi":"10.18311/jnr/2023/30792","DOIUrl":"https://doi.org/10.18311/jnr/2023/30792","url":null,"abstract":"Diabetes Mellitus (DM), a significant metabolic disorder that increases mortality and morbidity, affects people all over the world. Recently, many individuals are exploring CAM treatment that may have fewer side effects due to the prominent side effects of allopathic medications. Ziziphus jujuba (L.) Gaertn. (Rhamnaceae) stem bark has been a vital part of the conventional system of medicine for the management of diabetes, inflammation, wounds, fever, asthma and liver disorders. In spite of its pharmacological significance, Ziziphus jujuba stem bark lacks scientific evidence of its antidiabetic and antioxidant potential. Hence, an attempt has been made to evaluate the anti-diabetic effect of the stem bark of Ziziphus jujuba using alpha-amylase inhibition assay. In this research work, we further investigated the antioxidant activity of the Ziziphus jujuba using DPPH and Nitric oxide radical scavenging assay. The Chloroform (CEZJ), ethyl acetate (EAZJ) and Ethanol (EEZJ) extracts of Ziziphus jujuba stem bark were used in the study. In the DPPH radical scavenging assay, EEZJ had an IC50 value of 117.1 µg/ml, however, the value for the nitric oxide scavenging assay was 64.65 µg/ml. The Ziziphus jujuba was additionally examined for its in-vitro antidiabetic potential using an alpha-amylase inhibition assay, and it was discovered to possess a considerable percentage of alpha-amylase inhibition. The IC50 of EEZJ was found to be 34.68 µg/ml. These results imply that the Ziziphus jujuba possesses considerable antioxidant and anti-diabetic properties. To thoroughly establish the anti-diabetic potential of Ziziphus jujuba, additional in vitro experiments utilizing cell lines and other enzymes may be conducted.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"53 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135430927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
I. Sundara Ganesh, R. S. Parvathy, Divya Jayachandran, P. Hrudayakumari, V. Shalini
The current pharmacological investigation was performed to study the diuretic activity of Siddha polyherbal formulation Vithu Vagai Chooranam (VVC) in Wistar albino rats using the Lipschitz method. The animals were divided into four Groups (I, II, III, and IV) of six rats (n = 6) each. Group I served as control treated with milk (1ml/kg p.o), and Group II received Standard furosemide (10 mg/kg, p.o). Groups III and Group IV were treated with test drug at a dose of 70mg/kg and 90mg/kg, p.o, respectively. The urine volume, pH, and electrolyte concentration (Na+, K+ and Cl-) were estimated at the end of 24 hours. Diuretic index, Lipschitz values, and natriuretic index were also calculated from the results to make a comparison with control and furosemide-treated groups. Statistical analysis was carried out using a one-way analysis of variance, followed by Dunnett’s ‘t’ test. Oral administration of VVC at both doses significantly increased the urine output and concentration of urinary electrolytes (p < 0.01). The VVC-induced diuresis pattern was almost like that of frusemide. The findings revealed that the Vithu vagai chooranam possessed significant diuretic activity in experimental rats.
{"title":"Evaluation of Diuretic Activity of Siddha Poly Herbal Formulation <i>Vithu Vagai Chooranam</i> in Rodents","authors":"I. Sundara Ganesh, R. S. Parvathy, Divya Jayachandran, P. Hrudayakumari, V. Shalini","doi":"10.18311/jnr/2023/33995","DOIUrl":"https://doi.org/10.18311/jnr/2023/33995","url":null,"abstract":"The current pharmacological investigation was performed to study the diuretic activity of Siddha polyherbal formulation Vithu Vagai Chooranam (VVC) in Wistar albino rats using the Lipschitz method. The animals were divided into four Groups (I, II, III, and IV) of six rats (n = 6) each. Group I served as control treated with milk (1ml/kg p.o), and Group II received Standard furosemide (10 mg/kg, p.o). Groups III and Group IV were treated with test drug at a dose of 70mg/kg and 90mg/kg, p.o, respectively. The urine volume, pH, and electrolyte concentration (Na+, K+ and Cl-) were estimated at the end of 24 hours. Diuretic index, Lipschitz values, and natriuretic index were also calculated from the results to make a comparison with control and furosemide-treated groups. Statistical analysis was carried out using a one-way analysis of variance, followed by Dunnett’s ‘t’ test. Oral administration of VVC at both doses significantly increased the urine output and concentration of urinary electrolytes (p < 0.01). The VVC-induced diuresis pattern was almost like that of frusemide. The findings revealed that the Vithu vagai chooranam possessed significant diuretic activity in experimental rats.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"47 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135724327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The main global health issue, anxiety, and depression have significant psychological, social, and financial repercussions. It promotes an anticipatory and adaptable reaction to difficult or stressful situations. When anxiety is excessive, it destabilizes the person, which leads to a dysfunctional state. In the absence of intense situations, it’s a pathological state. It comprises posttraumatic stress disorder, general anxiety, aversion to social situations, obsessive-compulsive disorder, and panic disorder. Some people think about using natural therapies as an alternative to anxiety drugs because they may cause negative side effects. Due to their natural origins and lack of adverse effects, these medications and herbal medicine are becoming more and more popular in both developed and developing nations. Minerals, organic matter, and medicinal plants are the sources of many traditional remedies. Alkaloids, also saponins, glycosides, flavonoids, which, etc. are all present. The goal of this summary is to provide in-depth knowledge about the many phytoconstituents that have the potential to reduce anxiety and play a significant role in CNS activity.
{"title":"Role of Phytoflavonoids in the Management of Anxiety and Depression: An Overview","authors":"Avijit Mazumder, Arbaz Khan, Jatin Saini","doi":"10.18311/jnr/2023/33991","DOIUrl":"https://doi.org/10.18311/jnr/2023/33991","url":null,"abstract":"The main global health issue, anxiety, and depression have significant psychological, social, and financial repercussions. It promotes an anticipatory and adaptable reaction to difficult or stressful situations. When anxiety is excessive, it destabilizes the person, which leads to a dysfunctional state. In the absence of intense situations, it’s a pathological state. It comprises posttraumatic stress disorder, general anxiety, aversion to social situations, obsessive-compulsive disorder, and panic disorder. Some people think about using natural therapies as an alternative to anxiety drugs because they may cause negative side effects. Due to their natural origins and lack of adverse effects, these medications and herbal medicine are becoming more and more popular in both developed and developing nations. Minerals, organic matter, and medicinal plants are the sources of many traditional remedies. Alkaloids, also saponins, glycosides, flavonoids, which, etc. are all present. The goal of this summary is to provide in-depth knowledge about the many phytoconstituents that have the potential to reduce anxiety and play a significant role in CNS activity.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"49 11","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135723679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chitrali R. Talele, Dipali R. Talele, Gargee Barhate, Vasudev Bendre, Vedant Marda, Chirag Khandelwal
Onychomycosis, a fungus that causes nail colouring, nail separation, and nail plate growth, has infected the nail unit. There is a chance that the nail structure, nail bed, or nail layer could be infected. The term “onychomycosis” derives from the Greek words “onyx” (nail) and “mykes” (fungus). Around 50% of all consultations for nail diseases are for onychomycosis, the most common nail infection disorder. About 90% of toenail onychomycosis and 75% of fingernail onychomycosis are caused by dermophytes like Trichophyton rubrum and Trichophyton mentagrophytes. About 70% of yeast-borne onychomycosis cases are caused by Candida albicans. Epidemiological studies that have just been released estimate that onychomycosis affects every community worldwide at a rate of about 5.5 per cent. Onychomycosis is managed in different ways based on clinical categorization, the number of damaged nails, and the severity of the condition. The disadvantages of treatment are that oral therapies are frequently limited by drug interactions and probable hepatotoxicity, and topical antifungals have low efficacy if administered without nail plate biosurgery. The use of plants in medical treatments and herbal therapies is one of the less harmful, cheaper, and widely available alternatives to synthetic pharmaceuticals for treating fungal infections. Undoubtedly, dermatophytes can be inhibited by plant-based extracts as well as essential oils’ antifungal activities.
{"title":"Natural Remedies for Onychomycosis: A Review","authors":"Chitrali R. Talele, Dipali R. Talele, Gargee Barhate, Vasudev Bendre, Vedant Marda, Chirag Khandelwal","doi":"10.18311/jnr/2023/33695","DOIUrl":"https://doi.org/10.18311/jnr/2023/33695","url":null,"abstract":"Onychomycosis, a fungus that causes nail colouring, nail separation, and nail plate growth, has infected the nail unit. There is a chance that the nail structure, nail bed, or nail layer could be infected. The term “onychomycosis” derives from the Greek words “onyx” (nail) and “mykes” (fungus). Around 50% of all consultations for nail diseases are for onychomycosis, the most common nail infection disorder. About 90% of toenail onychomycosis and 75% of fingernail onychomycosis are caused by dermophytes like Trichophyton rubrum and Trichophyton mentagrophytes. About 70% of yeast-borne onychomycosis cases are caused by Candida albicans. Epidemiological studies that have just been released estimate that onychomycosis affects every community worldwide at a rate of about 5.5 per cent. Onychomycosis is managed in different ways based on clinical categorization, the number of damaged nails, and the severity of the condition. The disadvantages of treatment are that oral therapies are frequently limited by drug interactions and probable hepatotoxicity, and topical antifungals have low efficacy if administered without nail plate biosurgery. The use of plants in medical treatments and herbal therapies is one of the less harmful, cheaper, and widely available alternatives to synthetic pharmaceuticals for treating fungal infections. Undoubtedly, dermatophytes can be inhibited by plant-based extracts as well as essential oils’ antifungal activities.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"19 6","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135726965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Alzheimer’s disease is the most widespread advancing neurodegenerative disorder, and it is estimated that more than 50 million people have been affected worldwide. It is characterized by dementia, loss of sensory and motor function and difficulty in performing work. NMDA antagonists and acetylcholinesterase inhibitors are currently being used as treatment options for AD, but the treatment would not decline the disease progression as well as neurodegeneration. We used a unique humic acid and Fulvic acid mixture in the current investigation for the treatment of amyloid-β intoxicated Alzheimer’s in vitro model in SH-SY5Y cell line. Humic acid and fulvic acids are organic substances which will be produced by microorganism from the biomass such as dead matter of animal as well as plants. Both the components were used in the 1:1 ratio against AD induced cell line with optimum concentration 50μM/ml of each compound. The inflammatory mediators like Reactive Oxygen Species (ROS) were estimated using flow cytometry - H2DCFDA staining assay and cytokines such as TNF-α and IL-1β levels were estimated using ELISA. The results obtained from present study implicating that the humic acid and fulvic acids and their novel combinations lessen the ROS, cytokines level and decreased the apoptosis levels there by it exhibiting the neuro-protective mechanism via inhibiting neuro-inflammatory pathway in AD.
{"title":"<i>In Vitro</i> Pharmacological Evaluation of Fulvic Acid and Humic Acid Novel Combination in Amyloid Beta Intoxicated SH-SY5Y Cell Lines Model of Alzheimer’s Disease","authors":"Thamotharan Govindhasamy, Kumar Mohan","doi":"10.18311/jnr/2023/32992","DOIUrl":"https://doi.org/10.18311/jnr/2023/32992","url":null,"abstract":"Alzheimer’s disease is the most widespread advancing neurodegenerative disorder, and it is estimated that more than 50 million people have been affected worldwide. It is characterized by dementia, loss of sensory and motor function and difficulty in performing work. NMDA antagonists and acetylcholinesterase inhibitors are currently being used as treatment options for AD, but the treatment would not decline the disease progression as well as neurodegeneration. We used a unique humic acid and Fulvic acid mixture in the current investigation for the treatment of amyloid-β intoxicated Alzheimer’s in vitro model in SH-SY5Y cell line. Humic acid and fulvic acids are organic substances which will be produced by microorganism from the biomass such as dead matter of animal as well as plants. Both the components were used in the 1:1 ratio against AD induced cell line with optimum concentration 50μM/ml of each compound. The inflammatory mediators like Reactive Oxygen Species (ROS) were estimated using flow cytometry - H2DCFDA staining assay and cytokines such as TNF-α and IL-1β levels were estimated using ELISA. The results obtained from present study implicating that the humic acid and fulvic acids and their novel combinations lessen the ROS, cytokines level and decreased the apoptosis levels there by it exhibiting the neuro-protective mechanism via inhibiting neuro-inflammatory pathway in AD.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"19 7","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135726964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Anorectal disorders can cause discomfort and greatly affect a patient’s quality of life. Faulty lifestyles, and changing diet patterns, lead to various anorectal disorders. Bhagandara (Fistula in ano) is such a disorder regarded as one among the Ashtamahagadas by Acharyas. Acharya elaborated on Vrana, Dushtavrana, and its 60 different therapeutic procedures in Sushrutha Samhita. One of them is the Kshara application, a distinctive para-surgical technique that acts as a powerful debriding agent to promote the growth of healthy granulation tissue and efficient healing. The objective of the study is to know the role of the Kshara application in treating the post-fistulectomy wound. Method: In this study, the post-fistulectomy wound was treated with Yavakshara followed by daily cleaning and dressing with Jathyadi ghrita application for 14 days. The parameters like discharge, edge, floor, margin, surrounding area, bleeding, and temperature of the wound were assessed. Result: By the 6th day of application there were significant changes like the gradual desloughing process had started, and pus discharge was reduced. By the end of 14 days, discharge - absent, edge – not attached, floor- healthy granulation present, margin – regular, surrounding area – normal, bleeding – active bleeding present, temperature – absent. Conclusion: The application of Yavakshara was found to be effective in treating post-fistulectomy wounds with proper dressing and care by its wound-cleansing quality and debriding nature.
{"title":"Role of Yavakshara in the Management of Post Fistulectomy Wound – A Single Case Report","authors":"R. V. Sithara, Sanjay C. Babar","doi":"10.18311/jnr/2023/34366","DOIUrl":"https://doi.org/10.18311/jnr/2023/34366","url":null,"abstract":"Background: Anorectal disorders can cause discomfort and greatly affect a patient’s quality of life. Faulty lifestyles, and changing diet patterns, lead to various anorectal disorders. Bhagandara (Fistula in ano) is such a disorder regarded as one among the Ashtamahagadas by Acharyas. Acharya elaborated on Vrana, Dushtavrana, and its 60 different therapeutic procedures in Sushrutha Samhita. One of them is the Kshara application, a distinctive para-surgical technique that acts as a powerful debriding agent to promote the growth of healthy granulation tissue and efficient healing. The objective of the study is to know the role of the Kshara application in treating the post-fistulectomy wound. Method: In this study, the post-fistulectomy wound was treated with Yavakshara followed by daily cleaning and dressing with Jathyadi ghrita application for 14 days. The parameters like discharge, edge, floor, margin, surrounding area, bleeding, and temperature of the wound were assessed. Result: By the 6th day of application there were significant changes like the gradual desloughing process had started, and pus discharge was reduced. By the end of 14 days, discharge - absent, edge – not attached, floor- healthy granulation present, margin – regular, surrounding area – normal, bleeding – active bleeding present, temperature – absent. Conclusion: The application of Yavakshara was found to be effective in treating post-fistulectomy wounds with proper dressing and care by its wound-cleansing quality and debriding nature.","PeriodicalId":16393,"journal":{"name":"Journal of Natural Remedies","volume":"15 2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135875296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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