Pub Date : 2023-04-30DOI: 10.55522/jmpas.v12i2.4763
Noureddine Raiss
High genetic variability of the hepatitis C virus (HCV) due to copying errors during the viral cycle leads to the development of mutations, and resistance-associated variants (RAVs), even with the advent of direct-acting antivirals (DAAs). Assessment of the presence of these mutations is essential for targeted treatment regimens and proper infection management, as treatment is related to genotypes and developing mutations. The study investigates the presence of resistance mutations in the nonstructural protein 5B (NS5B) region in treatment naïve patients. 100 positive plasma samples from patients presented for a follow-up service of chronic HCV infection (CHC) at the National Institute of Hygiene (NIH) of Rabat-Morocco. NS5B sequencing revealed the presence of C316N in one treatment naïve patient of subtype 1b. Additionally, six treatment-naïve patients with subtypes 2a and 2i exhibited the presence of the M289L mutation.
{"title":"C316N Polymorphism associated with resistance to HCV polymerase NS5B in treatment-naïve patient with chronic hepatitis C","authors":"Noureddine Raiss","doi":"10.55522/jmpas.v12i2.4763","DOIUrl":"https://doi.org/10.55522/jmpas.v12i2.4763","url":null,"abstract":"High genetic variability of the hepatitis C virus (HCV) due to copying errors during the viral cycle leads to the development of mutations, and resistance-associated variants (RAVs), even with the advent of direct-acting antivirals (DAAs). Assessment of the presence of these mutations is essential for targeted treatment regimens and proper infection management, as treatment is related to genotypes and developing mutations. The study investigates the presence of resistance mutations in the nonstructural protein 5B (NS5B) region in treatment naïve patients. 100 positive plasma samples from patients presented for a follow-up service of chronic HCV infection (CHC) at the National Institute of Hygiene (NIH) of Rabat-Morocco. NS5B sequencing revealed the presence of C316N in one treatment naïve patient of subtype 1b. Additionally, six treatment-naïve patients with subtypes 2a and 2i exhibited the presence of the M289L mutation.","PeriodicalId":16445,"journal":{"name":"Journal of Medical pharmaceutical and allied sciences","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74898695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-30DOI: 10.55522/jmpas.v12i2.4768
V. Palanimuthu
Several anticancer drugs are getting resisted by the cancer cell and treatment like chemotherapy, radiation causes serious side effects. In immunomodulatory treatment the efficiency is less and CAR-T cells, CAR-NK cells require enormous time to get adopt to the in vitro and may cause seizures, dilemma, concussion in prolonged use against the cancer. Even the production of CAR-T cells and NK cells are tedious process. To overcome this situation, anticancer peptides can be used, as they don’t have any drug resistance and they can be highly potent, with good cell penetration. The advantages of these peptides are easy to modify, produce and formulate. This pandemic showed us that, identifying and characterizing a novel anticancer peptide (ACP) is an extremely time and labor consuming process. To reduce the time and labor, this study uses several in silico tools and algorithms like SVM, RF, XGBoost and KNN to predict a novel anticancer peptide. After several studies, with the collected data, a novel anticancer peptide – SSVAM-9 was predicted, which acts against the lung carcinoma. In this, anticancer activity prediction, cell permeation prediction with all 4 algorithms; stability prediction, allergenicity prediction and activity on lung carcinoma prediction were carried out in in silico model. Considering all the parameters, one best novel ACP was selected (SSVAM-9), and it can be easily formulated as the peptide is a stable one. This approach is an advantageous one as it is cost efficient and less-time consuming which can be studied in vivo and in vitro in future.
{"title":"Predicting, designing, characterization and evaluation of a new novel anticancer peptide SSVAM-9 against the lung carcinoma, an insilico approach","authors":"V. Palanimuthu","doi":"10.55522/jmpas.v12i2.4768","DOIUrl":"https://doi.org/10.55522/jmpas.v12i2.4768","url":null,"abstract":"Several anticancer drugs are getting resisted by the cancer cell and treatment like chemotherapy, radiation causes serious side effects. In immunomodulatory treatment the efficiency is less and CAR-T cells, CAR-NK cells require enormous time to get adopt to the in vitro and may cause seizures, dilemma, concussion in prolonged use against the cancer. Even the production of CAR-T cells and NK cells are tedious process. To overcome this situation, anticancer peptides can be used, as they don’t have any drug resistance and they can be highly potent, with good cell penetration. The advantages of these peptides are easy to modify, produce and formulate. This pandemic showed us that, identifying and characterizing a novel anticancer peptide (ACP) is an extremely time and labor consuming process. To reduce the time and labor, this study uses several in silico tools and algorithms like SVM, RF, XGBoost and KNN to predict a novel anticancer peptide. After several studies, with the collected data, a novel anticancer peptide – SSVAM-9 was predicted, which acts against the lung carcinoma. In this, anticancer activity prediction, cell permeation prediction with all 4 algorithms; stability prediction, allergenicity prediction and activity on lung carcinoma prediction were carried out in in silico model. Considering all the parameters, one best novel ACP was selected (SSVAM-9), and it can be easily formulated as the peptide is a stable one. This approach is an advantageous one as it is cost efficient and less-time consuming which can be studied in vivo and in vitro in future.","PeriodicalId":16445,"journal":{"name":"Journal of Medical pharmaceutical and allied sciences","volume":"404 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77465767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-30DOI: 10.55522/jmpas.v12i2.4561
Smita Daware
Chronic obstructive pulmonary disease is a significant state that leads to progressive airflow obstruction and subsequent irreversible damage to the airways. It is a major factor causing death and has a very high mortality rate worldwide. In recent years, the mortality rate has increased due to Chronic obstructive pulmonary disease (COPD) and it is estimated to increase in the coming years. This paper reviews the emerging techniques using these technologies that can be used to detect and monitor the severity of chronic obstructive pulmonary disease. The Internet of Things can help to detect and monitor the condition of a patient suffering from chronic obstructive pulmonary disease using sensors which are used to measure a particular parameter like concentration of different gases present in the exhaled breath and ensure that his condition doesn’t get worse. Using an Artificial Intelligence and Machine Learning based approach, a system can be developed where the data is collected from sensors, followed by pre-processing and feature extraction for further estimation using a model to identify a person suffering from this disease. The conventional methods used by medical practitioners for the detection of this disease are expensive, time consuming as a lot of tests are to be performed and can cause exposure to radiation. Therefore, research has been carried out in recent years to find other ways to detect this disease. It has been found that with the help of advancing technologies such as Internet of Things, Artificial Intelligence, Machine Learning and Signal processing techniques, it is possible to develop an easy, fast, non-invasive and cost-effective system that would help to diagnose and detect this disease and provide accurate results.
{"title":"A review on diagnosis of chronic obstructive pulmonary disease","authors":"Smita Daware","doi":"10.55522/jmpas.v12i2.4561","DOIUrl":"https://doi.org/10.55522/jmpas.v12i2.4561","url":null,"abstract":"Chronic obstructive pulmonary disease is a significant state that leads to progressive airflow obstruction and subsequent irreversible damage to the airways. It is a major factor causing death and has a very high mortality rate worldwide. In recent years, the mortality rate has increased due to Chronic obstructive pulmonary disease (COPD) and it is estimated to increase in the coming years. This paper reviews the emerging techniques using these technologies that can be used to detect and monitor the severity of chronic obstructive pulmonary disease. The Internet of Things can help to detect and monitor the condition of a patient suffering from chronic obstructive pulmonary disease using sensors which are used to measure a particular parameter like concentration of different gases present in the exhaled breath and ensure that his condition doesn’t get worse. Using an Artificial Intelligence and Machine Learning based approach, a system can be developed where the data is collected from sensors, followed by pre-processing and feature extraction for further estimation using a model to identify a person suffering from this disease. The conventional methods used by medical practitioners for the detection of this disease are expensive, time consuming as a lot of tests are to be performed and can cause exposure to radiation. Therefore, research has been carried out in recent years to find other ways to detect this disease. It has been found that with the help of advancing technologies such as Internet of Things, Artificial Intelligence, Machine Learning and Signal processing techniques, it is possible to develop an easy, fast, non-invasive and cost-effective system that would help to diagnose and detect this disease and provide accurate results.","PeriodicalId":16445,"journal":{"name":"Journal of Medical pharmaceutical and allied sciences","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82632189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-30DOI: 10.55522/jmpas.v12i2.5079
Jung ho Lee
The purpose of this study was to investigate the effect of proprioceptive neuromuscular facilitation on the balance and gait required for functional activities in patients with Parkinson's disease. 16 patients were randomly assigned to an experimental group receiving Proprioceptive neuromuscular facilitation (PNF) and a control group receiving functional electrical stimulation. BBS, POMA, and TUG were used before and after intervention to evaluate balance and walking ability required for functional activities of patients. In the study results, all groups showed a significant increase in intra-group evaluation using BBS, POMA, and TUG, and in the analysis to investigate the difference in treatment effect between groups, there was a significant difference in POMA and TUG in the experimental group compared to the control group. In conclusion, the intervention method using PNF has a positive effect on the functional activity of Parkinson's patients.
{"title":"Effects of proprioceptive neuromuscular facilitation on components of functional physical activity in patients with Parkinson’s disease","authors":"Jung ho Lee","doi":"10.55522/jmpas.v12i2.5079","DOIUrl":"https://doi.org/10.55522/jmpas.v12i2.5079","url":null,"abstract":"The purpose of this study was to investigate the effect of proprioceptive neuromuscular facilitation on the balance and gait required for functional activities in patients with Parkinson's disease. 16 patients were randomly assigned to an experimental group receiving Proprioceptive neuromuscular facilitation (PNF) and a control group receiving functional electrical stimulation. BBS, POMA, and TUG were used before and after intervention to evaluate balance and walking ability required for functional activities of patients. In the study results, all groups showed a significant increase in intra-group evaluation using BBS, POMA, and TUG, and in the analysis to investigate the difference in treatment effect between groups, there was a significant difference in POMA and TUG in the experimental group compared to the control group. In conclusion, the intervention method using PNF has a positive effect on the functional activity of Parkinson's patients.","PeriodicalId":16445,"journal":{"name":"Journal of Medical pharmaceutical and allied sciences","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77727694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-30DOI: 10.55522/jmpas.v12i2.4734
Sreenivas Murthy Doddasamiah
We aim to explore the relationship between work pressure and depression, and sexual desire in a healthcare professional. A cross-sectional study was conducted with healthcare professionals between the age of 18-45 years in a multispecialty healthcare institute using the Hamilton Depression Rating scale (HAMD), and Telford and Wrekin sexual health questionnaire. In total, 150 people participated in our study, with a mean age of 28.83 ± 5.56 years. Among them22.0% of respondents had low work pressure, 42.7% had moderate work pressure, and 35.3% had heavy work pressure. In terms of sexual desire, 20.7% (31) of the participants desired to have sexual relations every day, 22% (33) twice a week, 22% (33) once a week, 15.3% (23) once a month, and 20% (30) of the participants did not have sexual desire. As per the HAM-D scale assessment, 40.7% of the participants were normal, while 12.7 % had mild depression. People who were moderately, severely, or highly depressed made-up 16%, 10.7%, and 20% of the participants, respectively. A chi-square test was used to examine the relationship between the two variables. There was no statistically significant difference in the presence of depression among work pressure (p>0.05). There was a statistically significant difference in sexual desire among work pressure (p<0.001). The study concluded that there was no difference in the presence of depression among various levels of work pressure, and there was a difference in sexual desire.
{"title":"The association of work pressure with depression and sexual desire a cross-sectional study among health care professional","authors":"Sreenivas Murthy Doddasamiah","doi":"10.55522/jmpas.v12i2.4734","DOIUrl":"https://doi.org/10.55522/jmpas.v12i2.4734","url":null,"abstract":"We aim to explore the relationship between work pressure and depression, and sexual desire in a healthcare professional. A cross-sectional study was conducted with healthcare professionals between the age of 18-45 years in a multispecialty healthcare institute using the Hamilton Depression Rating scale (HAMD), and Telford and Wrekin sexual health questionnaire. In total, 150 people participated in our study, with a mean age of 28.83 ± 5.56 years. Among them22.0% of respondents had low work pressure, 42.7% had moderate work pressure, and 35.3% had heavy work pressure. In terms of sexual desire, 20.7% (31) of the participants desired to have sexual relations every day, 22% (33) twice a week, 22% (33) once a week, 15.3% (23) once a month, and 20% (30) of the participants did not have sexual desire. As per the HAM-D scale assessment, 40.7% of the participants were normal, while 12.7 % had mild depression. People who were moderately, severely, or highly depressed made-up 16%, 10.7%, and 20% of the participants, respectively. A chi-square test was used to examine the relationship between the two variables. There was no statistically significant difference in the presence of depression among work pressure (p>0.05). There was a statistically significant difference in sexual desire among work pressure (p<0.001). The study concluded that there was no difference in the presence of depression among various levels of work pressure, and there was a difference in sexual desire.","PeriodicalId":16445,"journal":{"name":"Journal of Medical pharmaceutical and allied sciences","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83694282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-30DOI: 10.55522/jmpas.v12i2.4244
Natia Bokuchava
Georgia is one of the world's oldest wine areas. Interest to by-products of vine processing is rising because they may be exploited as source of bioactive compounds for pharmaceutical and cosmetic purposes, rather than being discarded. The aim of the present research was to study polyphenolic compounds content in Saperavi grapevine shoots extract. Shoots of Saperavi grapevine were collected in Kakheti, Georgia. Extract was preliminary prepared and concentrated 4-fold. Polyphenols were extracted using Methanol and total phenolic content (TPC) was measured with Folin-Ciocalteu (F-C) reagent in terms of Gallic acid. The qualitative composition and content of phenolic compounds was studied with Liquid Chromatography - tandem Mass Spectrometry (LC–MS/MS). The identification was achieved by comparison of the retention times (tR) and spectra characteristics of individual compounds with those in data library. As a result, 14 different phenolic compounds were isolated. Received results demonstrated possibility of using Georgian Saperavi grapevine shoots as a source of biologically active ingredients, for which studies should be proceeded accordingly. This research № PHDF-21-1607 has been supported by Shota Rustaveli National Science Foundation (SRNSFG).
{"title":"Study of phenolic content using LC–MS/MS technic in Saperavi grapevine shoots growing in Georgia","authors":"Natia Bokuchava","doi":"10.55522/jmpas.v12i2.4244","DOIUrl":"https://doi.org/10.55522/jmpas.v12i2.4244","url":null,"abstract":"Georgia is one of the world's oldest wine areas. Interest to by-products of vine processing is rising because they may be exploited as source of bioactive compounds for pharmaceutical and cosmetic purposes, rather than being discarded. The aim of the present research was to study polyphenolic compounds content in Saperavi grapevine shoots extract. Shoots of Saperavi grapevine were collected in Kakheti, Georgia. Extract was preliminary prepared and concentrated 4-fold. Polyphenols were extracted using Methanol and total phenolic content (TPC) was measured with Folin-Ciocalteu (F-C) reagent in terms of Gallic acid. The qualitative composition and content of phenolic compounds was studied with Liquid Chromatography - tandem Mass Spectrometry (LC–MS/MS). The identification was achieved by comparison of the retention times (tR) and spectra characteristics of individual compounds with those in data library. As a result, 14 different phenolic compounds were isolated. Received results demonstrated possibility of using Georgian Saperavi grapevine shoots as a source of biologically active ingredients, for which studies should be proceeded accordingly. This research № PHDF-21-1607 has been supported by Shota Rustaveli National Science Foundation (SRNSFG).","PeriodicalId":16445,"journal":{"name":"Journal of Medical pharmaceutical and allied sciences","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75165968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-30DOI: 10.55522/jmpas.v12i2.4056
Jannathul Firdous
Female genital tract infections are major public health problems, with considerable economic consequences. Drugs like metronidazole and clindamycin are unable to control the growth of vaginal infection completely, which requires alternate novel treatment strategies. Some herbal antimicrobial agents are reported to inhibit the growth of vaginal infection. Boerhaavia diffusa andAzadirachta indica are such herbs with antimicrobial, antioxidant and anti-inflammatory properties. In the present study, vaginal fluid samples from infected patients were collected and cultured using different media. Isolated pathogens were identified using 16S rRNA sequence. Four bacterial pathogens were isolated and identified. The pathogens identified were Aeromonas cavia, Lactobacillus, Staphylococcus aureus and Klebsiella pneumomiae. Anti-vaginalis activity of the two herbs were analysed in an isolated pathogen. Maximum zone of inhibition was observed against S. aureus and Aeromonas caviae. The present investigation confirmed that, Boerhaavia diffusa andAzadirachta indica herbal extracts were able to control the vaginal pathogens without any side-effects
{"title":"Vaginitis phyto therapy against vaginal pathogen and molecular identification of isolated vaginal pathogen","authors":"Jannathul Firdous","doi":"10.55522/jmpas.v12i2.4056","DOIUrl":"https://doi.org/10.55522/jmpas.v12i2.4056","url":null,"abstract":"Female genital tract infections are major public health problems, with considerable economic consequences. Drugs like metronidazole and clindamycin are unable to control the growth of vaginal infection completely, which requires alternate novel treatment strategies. Some herbal antimicrobial agents are reported to inhibit the growth of vaginal infection. Boerhaavia diffusa andAzadirachta indica are such herbs with antimicrobial, antioxidant and anti-inflammatory properties. In the present study, vaginal fluid samples from infected patients were collected and cultured using different media. Isolated pathogens were identified using 16S rRNA sequence. Four bacterial pathogens were isolated and identified. The pathogens identified were Aeromonas cavia, Lactobacillus, Staphylococcus aureus and Klebsiella pneumomiae. Anti-vaginalis activity of the two herbs were analysed in an isolated pathogen. Maximum zone of inhibition was observed against S. aureus and Aeromonas caviae. The present investigation confirmed that, Boerhaavia diffusa andAzadirachta indica herbal extracts were able to control the vaginal pathogens without any side-effects","PeriodicalId":16445,"journal":{"name":"Journal of Medical pharmaceutical and allied sciences","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91333922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-30DOI: 10.55522/jmpas.v12i2.4719
Jung-Ho Lee
This study was conducted to investigate the effects of unaffected-side active treatment on the gait of hemiplegic patients. The study subjects were 20 patients who showed hemiplegic symptoms after a stroke. Through a random classification method, the subjects were divided into an experimental group (n = 10) who underwent treadmill exercise based on the concept of unaffected-side active treatment to strengthen the paretic side lower extremity after proprioceptive neuromuscular facilitation (PNF) treatment and a control group (n = 10) who underwent general treadmill training without unaffected side-active treatment after PNF treatment. The therapeutic interventions were performed three times a week for 4 weeks. To analyze behavioural motor motions, the patient's gait speeds and ankle angles were measured using the timed up-and-go (TUG) and the Dartfish program before treatment and 14 and 28 days after beginning treatment. The study results showed that the TUG and ankle angles significantly differed between the experimental and control groups at 14 and 28 days after beginning treatment. These significant differences between the two groups were verified. In conclusion, a lower limb strengthening treadmill exercise based on unaffected-side active treatment can increase gait speed and ankle angle by improving motor control ability
{"title":"The effect of the concept of modified unaffected-side active treatment on the gaits of patients with central nervous system damage","authors":"Jung-Ho Lee","doi":"10.55522/jmpas.v12i2.4719","DOIUrl":"https://doi.org/10.55522/jmpas.v12i2.4719","url":null,"abstract":"This study was conducted to investigate the effects of unaffected-side active treatment on the gait of hemiplegic patients. The study subjects were 20 patients who showed hemiplegic symptoms after a stroke. Through a random classification method, the subjects were divided into an experimental group (n = 10) who underwent treadmill exercise based on the concept of unaffected-side active treatment to strengthen the paretic side lower extremity after proprioceptive neuromuscular facilitation (PNF) treatment and a control group (n = 10) who underwent general treadmill training without unaffected side-active treatment after PNF treatment. The therapeutic interventions were performed three times a week for 4 weeks. To analyze behavioural motor motions, the patient's gait speeds and ankle angles were measured using the timed up-and-go (TUG) and the Dartfish program before treatment and 14 and 28 days after beginning treatment. The study results showed that the TUG and ankle angles significantly differed between the experimental and control groups at 14 and 28 days after beginning treatment. These significant differences between the two groups were verified. In conclusion, a lower limb strengthening treadmill exercise based on unaffected-side active treatment can increase gait speed and ankle angle by improving motor control ability","PeriodicalId":16445,"journal":{"name":"Journal of Medical pharmaceutical and allied sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77986151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-30DOI: 10.55522/jmpas.v12i2.4410
K. Ramadoss
The main aim of this study is to develop a rapid and cheap Ultraviolet (UV) spectrophotometric method for the estimation of Favipiravir (400mg) in tablets and validate as per International Conference on Harmonization (ICH) guidelines. The developed method uses the solvent Ethanol: Water (30:70) for the assay of Favipiravir whose λmax was found to be 231nm. In this method, Favipiravirshows linearity in the range 2-10 μg/ml. The accuracy was carried out by using standard addition method and the precision is ascertained by calculating the relative standard deviation. A cheap and rapid UV spectrophotometric method was developed and validated for the estimation of Favipiravir and hence it can be used for the routine pharmaceutical analysis.
{"title":"Quantitative analysis of favipiravir in bulk and pharmaceutical dosage forms using UV visible spectrophotometer","authors":"K. Ramadoss","doi":"10.55522/jmpas.v12i2.4410","DOIUrl":"https://doi.org/10.55522/jmpas.v12i2.4410","url":null,"abstract":"The main aim of this study is to develop a rapid and cheap Ultraviolet (UV) spectrophotometric method for the estimation of Favipiravir (400mg) in tablets and validate as per International Conference on Harmonization (ICH) guidelines. The developed method uses the solvent Ethanol: Water (30:70) for the assay of Favipiravir whose λmax was found to be 231nm. In this method, Favipiravirshows linearity in the range 2-10 μg/ml. The accuracy was carried out by using standard addition method and the precision is ascertained by calculating the relative standard deviation. A cheap and rapid UV spectrophotometric method was developed and validated for the estimation of Favipiravir and hence it can be used for the routine pharmaceutical analysis.","PeriodicalId":16445,"journal":{"name":"Journal of Medical pharmaceutical and allied sciences","volume":"49 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86767882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-30DOI: 10.55522/jmpas.v12i2.4748
Ahmed Atia
Self-medication is a widespread practice that may contribute to the antibiotic resistance of human pathogens. This study was aimed to determine the prevalence of self-medication among Libyan patients in Tripoli city. This descriptive, questionnaire- based cross-sectional study was conducted from August to October 2022 among Libyan patients in Tripoli city. The questionnaire was compromising from 13 questions. Three questions were dedicated to the general demographics and the next 10 questions were based on self-medication of drugs for the prevention and treatment of respiratory symptoms. All these questions if answered as a "No" was considered as self-medication. Among 214 participants, 176 (82%) were found to have practiced self-medication; 38.3% of them were aged less than 25 years, the majority being males (60.7%). Lack of time and feeling confidence with self-medication practice were the most common reasons cited behind practicing self-medication. Pain suppressing medications were the most selfmedicated drugs by 55.68%. Pharmacies (67.05%) were the commonest source regarding medicines for self-medication. The higher educated tended to self-medicate more than those with a low level of education. The majority of the respondents to the study reported self-medicating. Therefore, it's essential to enforce the law strictly and raise public awareness of the negative effects of self-medication.
{"title":"Self-medication's knowledge and practice in adults attending pharmacies in Tripoli, Libya","authors":"Ahmed Atia","doi":"10.55522/jmpas.v12i2.4748","DOIUrl":"https://doi.org/10.55522/jmpas.v12i2.4748","url":null,"abstract":"Self-medication is a widespread practice that may contribute to the antibiotic resistance of human pathogens. This study was aimed to determine the prevalence of self-medication among Libyan patients in Tripoli city. This descriptive, questionnaire- based cross-sectional study was conducted from August to October 2022 among Libyan patients in Tripoli city. The questionnaire was compromising from 13 questions. Three questions were dedicated to the general demographics and the next 10 questions were based on self-medication of drugs for the prevention and treatment of respiratory symptoms. All these questions if answered as a \"No\" was considered as self-medication. Among 214 participants, 176 (82%) were found to have practiced self-medication; 38.3% of them were aged less than 25 years, the majority being males (60.7%). Lack of time and feeling confidence with self-medication practice were the most common reasons cited behind practicing self-medication. Pain suppressing medications were the most selfmedicated drugs by 55.68%. Pharmacies (67.05%) were the commonest source regarding medicines for self-medication. The higher educated tended to self-medicate more than those with a low level of education. The majority of the respondents to the study reported self-medicating. Therefore, it's essential to enforce the law strictly and raise public awareness of the negative effects of self-medication.","PeriodicalId":16445,"journal":{"name":"Journal of Medical pharmaceutical and allied sciences","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80278418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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