Pub Date : 2023-07-03DOI: 10.55522/jmpas.v12i3.5020
Nivedita Singh, R. .. Talwekar
Obstructive Sleep apnea (OSA) is a type of sleep disorder caused due to respiratory collapse during sleep. This sleep disorder generally goes undiagnosed and neglected. Severe OSA may cause arrhythmia, sudden death, high blood pressure, and other cardiac anomalies. Polysomnography (PSG) is the most popular gold standard used by many researchers to detect OSA. PSG required a well-equipped sleep laboratory and skilled persons to record multi- channel signals to detect OSA. PSG is a complex and expensive method and hence motivated to conduct the research using single-channel electrocardiogram (ECG). An automatic detection method of OSA using single-channel ECG in Convolutional Neural Network (CNN) takes less computing time as feature engineering does not require. This paper focuses on the automatic detection of OSA using ECG with two different deep CNN architectures AlexNet and GoogLeNet transfer learning. The apnea ECG datasheet is used for assessing the method proposed. The state of art using deep learning models are applied to single-channel ECG data. The GoogLeNet architecture is more complex and achieves 100% accuracy whereas AlexNet architecture shows 99.7% accuracy to detect OSA. The proposed work is applied to physionet apnea ECG online data which leads to an overfitting problem that can be resolved using clinical data to further enhance the robustness of the model.
{"title":"Comparison of ALEXNET and GOOGLENET convolutional neural network models to detect obstructive sleep apnea using single-channel electrocardiogram","authors":"Nivedita Singh, R. .. Talwekar","doi":"10.55522/jmpas.v12i3.5020","DOIUrl":"https://doi.org/10.55522/jmpas.v12i3.5020","url":null,"abstract":"Obstructive Sleep apnea (OSA) is a type of sleep disorder caused due to respiratory collapse during sleep. This sleep disorder generally goes undiagnosed and neglected. Severe OSA may cause arrhythmia, sudden death, high blood pressure, and other cardiac anomalies. Polysomnography (PSG) is the most popular gold standard used by many researchers to detect OSA. PSG required a well-equipped sleep laboratory and skilled persons to record multi- channel signals to detect OSA. PSG is a complex and expensive method and hence motivated to conduct the research using single-channel electrocardiogram (ECG). An automatic detection method of OSA using single-channel ECG in Convolutional Neural Network (CNN) takes less computing time as feature engineering does not require. This paper focuses on the automatic detection of OSA using ECG with two different deep CNN architectures AlexNet and GoogLeNet transfer learning. The apnea ECG datasheet is used for assessing the method proposed. The state of art using deep learning models are applied to single-channel ECG data. The GoogLeNet architecture is more complex and achieves 100% accuracy whereas AlexNet architecture shows 99.7% accuracy to detect OSA. The proposed work is applied to physionet apnea ECG online data which leads to an overfitting problem that can be resolved using clinical data to further enhance the robustness of the model.","PeriodicalId":16445,"journal":{"name":"Journal of Medical pharmaceutical and allied sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78407429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-03DOI: 10.55522/jmpas.v12i3.4556
Amal Chairi-Achari, Ahmed Oubaasri, R. Razine, A. Barkat, M. Obtel
Currently, early detection of neonatal pathologies is fundamental to permanently eliminating the resulting disabilities. It represents a governmental priority. The aim of this study is to describe the response of health professionals to the need for early detection of disabling neonatal pathologies, and the factors that influence this answer and propose areas for improvement. The study adopted a descriptive and exploratory type, multicentric and quantitative, carried out between October and December 2021 using a questionnaire shared with 206 health professionals in Rabat prefecture. In all, 92 health professionals participated in the study and completed the questionnaire, of which 87% were women and 13% were men. Most participants were aged 41 to 50, 88% of participants had more than 10 years of service, and 57% of participants were doctors. In addition, 26% of participants had a negative perception of people with disabilities, 75% participants did not systematically screen newborns for disabling diseases, more than 59% of the participants knew neither the means nor the structures for dealing with disabilities nor the rights of people with disabilities, and 88% participants had never received training in disability and its medical and social care. This study represents a real opportunity and an innovation that, by presenting an initial assessment of the current response of health professionals to the need for early detection of newborns with disabling pathologies, will enable those responsible at different levels to reflect on an existing and priority problem.
{"title":"Early detection of disabling neonatal diseases in Morocco: a study exploring the response of health professionals","authors":"Amal Chairi-Achari, Ahmed Oubaasri, R. Razine, A. Barkat, M. Obtel","doi":"10.55522/jmpas.v12i3.4556","DOIUrl":"https://doi.org/10.55522/jmpas.v12i3.4556","url":null,"abstract":"Currently, early detection of neonatal pathologies is fundamental to permanently eliminating the resulting disabilities. It represents a governmental priority. The aim of this study is to describe the response of health professionals to the need for early detection of disabling neonatal pathologies, and the factors that influence this answer and propose areas for improvement. The study adopted a descriptive and exploratory type, multicentric and quantitative, carried out between October and December 2021 using a questionnaire shared with 206 health professionals in Rabat prefecture. In all, 92 health professionals participated in the study and completed the questionnaire, of which 87% were women and 13% were men. Most participants were aged 41 to 50, 88% of participants had more than 10 years of service, and 57% of participants were doctors. In addition, 26% of participants had a negative perception of people with disabilities, 75% participants did not systematically screen newborns for disabling diseases, more than 59% of the participants knew neither the means nor the structures for dealing with disabilities nor the rights of people with disabilities, and 88% participants had never received training in disability and its medical and social care. This study represents a real opportunity and an innovation that, by presenting an initial assessment of the current response of health professionals to the need for early detection of newborns with disabling pathologies, will enable those responsible at different levels to reflect on an existing and priority problem.","PeriodicalId":16445,"journal":{"name":"Journal of Medical pharmaceutical and allied sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83090764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A majority of recently invented medications have been discovered to be poorly water-soluble and cause delays in the formulation and development of dosage forms. Solubility has been a major problem for BCS classes II and IV. As a result, nanotechnology may be useful in resolving the solubility problem. This review will cover Nanocrystals, as well as the numerous methodologies employed in their formulation and their application. Nanocrystals are nanometre-sized drug particles of a poorly water-soluble compound. They are distinct from polymeric nanoparticles in that they are entirely made up of the drug. Nanocrystals can be implemented to increase the rate of dissolution and saturation solubility of active pharmaceutical ingredients. Milling, high-pressure homogenization, precipitation, and combination methods such as Nanoedge andSmartCrystal, are among the approaches available for its formulation. The transition of nanocrystals into final formulations, as well as future nanocrystal trends, are also discussed.
{"title":"Nano-crystals a comprehensive review on formulation and application perspectives","authors":"Rakesh Mishra, Sagar Dhadwad, Akash Aher, Prajakta Dhokale","doi":"10.55522/jmpas.v12i3.4798","DOIUrl":"https://doi.org/10.55522/jmpas.v12i3.4798","url":null,"abstract":"A majority of recently invented medications have been discovered to be poorly water-soluble and cause delays in the formulation and development of dosage forms. Solubility has been a major problem for BCS classes II and IV. As a result, nanotechnology may be useful in resolving the solubility problem. This review will cover Nanocrystals, as well as the numerous methodologies employed in their formulation and their application. Nanocrystals are nanometre-sized drug particles of a poorly water-soluble compound. They are distinct from polymeric nanoparticles in that they are entirely made up of the drug. Nanocrystals can be implemented to increase the rate of dissolution and saturation solubility of active pharmaceutical ingredients. Milling, high-pressure homogenization, precipitation, and combination methods such as Nanoedge andSmartCrystal, are among the approaches available for its formulation. The transition of nanocrystals into final formulations, as well as future nanocrystal trends, are also discussed.","PeriodicalId":16445,"journal":{"name":"Journal of Medical pharmaceutical and allied sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84538324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-03DOI: 10.55522/jmpas.v12i3.4971
M. Banias, Mylene Mondarte Uy
Cancer is a major cause of mortality worldwide, and marine sponges have emerged as potential sources of anticancer agents. In this study, we investigated the antiproliferative and pro-apoptotic effects of a marine sponge extract from Tedania sp. against the human colorectal carcinoma cell line (HCT116) using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and Caspase-Glo® 3/7 assays. The extract was prepared using a polar solvent mixture of ethanol:water, and was subjected to reversed-phase flash chromatography consisiting of water(W), acetonitrile(ACN), and ethyl acetate(EA) gradient eluent, yielding 16 Fraction. Treatment of HCT116 cells with Fractions 1-16 showed that only Fraction 16, consisting of 100�, exhibited significant (p<0.05) cytotoxic activity with the lowest viability of 90.9% compared to the negative control. Furthermore, Fraction 9, consisting of 20:80 W and ACN, showed a significantly (p<0.05) highest fold change (FC) value of 2.89 indicating an almost threefold increase in caspase-3/7 activity. These results demonstrate that the Tedania sp. extract has promising antiproliferative and pro-apoptotic effects against HCT116 cell lines, indicating its potential as an anticancer agent.
{"title":"Antiproliferative and pro-apoptotic effects on cancer cell line HCT116 using marine sponge Tedania species collected from Kalangahan, Lugait, Misamis Oriental, Philippines","authors":"M. Banias, Mylene Mondarte Uy","doi":"10.55522/jmpas.v12i3.4971","DOIUrl":"https://doi.org/10.55522/jmpas.v12i3.4971","url":null,"abstract":"Cancer is a major cause of mortality worldwide, and marine sponges have emerged as potential sources of anticancer agents. In this study, we investigated the antiproliferative and pro-apoptotic effects of a marine sponge extract from Tedania sp. against the human colorectal carcinoma cell line (HCT116) using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and Caspase-Glo® 3/7 assays. The extract was prepared using a polar solvent mixture of ethanol:water, and was subjected to reversed-phase flash chromatography consisiting of water(W), acetonitrile(ACN), and ethyl acetate(EA) gradient eluent, yielding 16 Fraction. Treatment of HCT116 cells with Fractions 1-16 showed that only Fraction 16, consisting of 100�, exhibited significant (p<0.05) cytotoxic activity with the lowest viability of 90.9% compared to the negative control. Furthermore, Fraction 9, consisting of 20:80 W and ACN, showed a significantly (p<0.05) highest fold change (FC) value of 2.89 indicating an almost threefold increase in caspase-3/7 activity. These results demonstrate that the Tedania sp. extract has promising antiproliferative and pro-apoptotic effects against HCT116 cell lines, indicating its potential as an anticancer agent.","PeriodicalId":16445,"journal":{"name":"Journal of Medical pharmaceutical and allied sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91187241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-03DOI: 10.55522/jmpas.v12i3.5128
S. Shah, A. Bansal, Anubha Sharma, Lakshay Kaushik, R. Das
As hypertension, almost 90% of cases of hypertension with an unknown origin called essential hypertension, continue to be one of the most important risk factors for various fatal health conditions, its early diagnosis using trustworthy biomarkers to predict, diagnose, and monitor the therapeutic progress of hypertension is proving to be of utmost importance for the preventive as well as curative purpose of various health hazards. A rise in the activity of biochemical markers of endothelial dysfunction and blood lipids, notablyLow-density lipoprotein (LDL) andverylow-density lipoprotein(VLDL)measurements, and inflammation markers including C-reactive protein(CRP), cytokines, and adhesion molecules are linked to the development of hypertension. Growth and differentiation factor-15, red cell distribution width, uric acid, creatinine, inflammatory markers including interleukin-6, angiopoietins, and microRNAs are prognostic indicators in individuals with pulmonary arterial hypertension (PAH).The most extensively used blood markers for portal hypertension (PH) are the fibrosis-4 index and the improved liver fibrosis test. Likewise, Hepatic venous pressure gradient (HVPG), liver/SSMs and Plasma cyclic guanosine monophosphate (cGMP) being clinically significant tools to assess for PH. Along with Copeptin, serum levels of uric acid, potassium, and sodium may be crucial for the identification and monitoring of hypertension in pediatrics.Similarly, the severity of gestational hypertension correlates with hyperuricemia, elevated CRP, and interleukin-1 serum levels. Here, in this study, literature on biomarkers has been reviewed which are versatile diagnostic tools posing that influence healthcare professionals’ judgment and assist in patient education regarding diagnosis, prognosis, early detection, and treatment intervention.
{"title":"Diagnosis and management of hypertension understanding imperative role of various biomarkers","authors":"S. Shah, A. Bansal, Anubha Sharma, Lakshay Kaushik, R. Das","doi":"10.55522/jmpas.v12i3.5128","DOIUrl":"https://doi.org/10.55522/jmpas.v12i3.5128","url":null,"abstract":"As hypertension, almost 90% of cases of hypertension with an unknown origin called essential hypertension, continue to be one of the most important risk factors for various fatal health conditions, its early diagnosis using trustworthy biomarkers to predict, diagnose, and monitor the therapeutic progress of hypertension is proving to be of utmost importance for the preventive as well as curative purpose of various health hazards. A rise in the activity of biochemical markers of endothelial dysfunction and blood lipids, notablyLow-density lipoprotein (LDL) andverylow-density lipoprotein(VLDL)measurements, and inflammation markers including C-reactive protein(CRP), cytokines, and adhesion molecules are linked to the development of hypertension. Growth and differentiation factor-15, red cell distribution width, uric acid, creatinine, inflammatory markers including interleukin-6, angiopoietins, and microRNAs are prognostic indicators in individuals with pulmonary arterial hypertension (PAH).The most extensively used blood markers for portal hypertension (PH) are the fibrosis-4 index and the improved liver fibrosis test. Likewise, Hepatic venous pressure gradient (HVPG), liver/SSMs and Plasma cyclic guanosine monophosphate (cGMP) being clinically significant tools to assess for PH. Along with Copeptin, serum levels of uric acid, potassium, and sodium may be crucial for the identification and monitoring of hypertension in pediatrics.Similarly, the severity of gestational hypertension correlates with hyperuricemia, elevated CRP, and interleukin-1 serum levels. Here, in this study, literature on biomarkers has been reviewed which are versatile diagnostic tools posing that influence healthcare professionals’ judgment and assist in patient education regarding diagnosis, prognosis, early detection, and treatment intervention.","PeriodicalId":16445,"journal":{"name":"Journal of Medical pharmaceutical and allied sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84904616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-07-03DOI: 10.55522/jmpas.v12i3.4662
A. Agu, Patience Orji, S. Chime, Kelechi Duru, V. Nwannadi
This study evaluated the protective effect of an aqueous leaf extract of Vernonia amygdalina on the kidney functions and histological architecture of gentamicin-induced nephrotoxicity in adult Wistar rats. Twenty-five (25) Wistar rats were divided into five groups (groups 1–5), with five rats in each group. Group 1 served as the normal control. Group 2 was the negative control and received 40 mg/kg of body weight of gentamicin. Groups 3, 4, and 5 received an aqueous extract of V. amygdalina at doses of 100 mg, 200 mg, and 400 mg/kg of body weight, respectively, for 21 days. The gentamicin was administered intraperitoneally for 14 days, starting on day 8, while the aqueous leaf extract was given orally. There was a significant (P< 0.05) increase or derangement in the serum levels of urea, creatinine, and potassium in group 2 when compared to the normal control. The groups that received the extract of V. amygdalina showed a significant (P<0.05) reduction in the levels of deranged serum urea, creatinine, and potassium compared to group 2. The kidney histological photomicrograph of group 2 was characterized by epitheloid granulomas, glomerular necrosis, and severe nephrotic tissue degeneration. The groups treated with the extract showed significant protection against these alterations. The protection was found to be dose-dependent. It was discovered that V. amygdalina had a dose-dependent protective effect against kidney damage caused by gentamycin toxicity.
{"title":"Protective effect of aqueous leaf extract of vernonia amygdalina (bitter leaf) on gentamicin induced nephrotoxicity in adult wistar rat","authors":"A. Agu, Patience Orji, S. Chime, Kelechi Duru, V. Nwannadi","doi":"10.55522/jmpas.v12i3.4662","DOIUrl":"https://doi.org/10.55522/jmpas.v12i3.4662","url":null,"abstract":"This study evaluated the protective effect of an aqueous leaf extract of Vernonia amygdalina on the kidney functions and histological architecture of gentamicin-induced nephrotoxicity in adult Wistar rats. Twenty-five (25) Wistar rats were divided into five groups (groups 1–5), with five rats in each group. Group 1 served as the normal control. Group 2 was the negative control and received 40 mg/kg of body weight of gentamicin. Groups 3, 4, and 5 received an aqueous extract of V. amygdalina at doses of 100 mg, 200 mg, and 400 mg/kg of body weight, respectively, for 21 days. The gentamicin was administered intraperitoneally for 14 days, starting on day 8, while the aqueous leaf extract was given orally. There was a significant (P< 0.05) increase or derangement in the serum levels of urea, creatinine, and potassium in group 2 when compared to the normal control. The groups that received the extract of V. amygdalina showed a significant (P<0.05) reduction in the levels of deranged serum urea, creatinine, and potassium compared to group 2. The kidney histological photomicrograph of group 2 was characterized by epitheloid granulomas, glomerular necrosis, and severe nephrotic tissue degeneration. The groups treated with the extract showed significant protection against these alterations. The protection was found to be dose-dependent. It was discovered that V. amygdalina had a dose-dependent protective effect against kidney damage caused by gentamycin toxicity.","PeriodicalId":16445,"journal":{"name":"Journal of Medical pharmaceutical and allied sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90882579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-30DOI: 10.55522/jmpas.v12i2.4925
Elfita Elfita
Traditional medicine is still used by the community to prevent and treat various diseases, including infectious diseases and exposure the free radicals. The part of the medicinal plant that is often used as traditional medicine is root bark of sungkai. This study explored endophytic fungi from root bark of sungkai and determined their antibacterial and antioxidant activities. Endophytic fungi were isolated from fresh root bark tissue in PDA (Potato Dextrose Agar) media and identified morphologically. The DPPH (2,2-diphenyl-1-picrylhydrazyl) and diffused-disc paper methods were used for antioxidant and antibacterial. The endophytic fungi extracts showing the best bioactivity were identified molecularly. A total of 6 isolates of endophytic fungi were found in this study (RNA1-RNA6). Antibacterial and antioxidant activity test showed the best activity for RNA4 isolates. Molecular identification results describe it as Penicillium janczewskii. This research can be used as a basic reference for isolating pure compounds that have antibacterial and antioxidant properties through chromatography techniques
{"title":"Endophytic fungi isolated from the root bark of sungkai (Peronema canescens) as Anti-bacterial and antioxidant","authors":"Elfita Elfita","doi":"10.55522/jmpas.v12i2.4925","DOIUrl":"https://doi.org/10.55522/jmpas.v12i2.4925","url":null,"abstract":"Traditional medicine is still used by the community to prevent and treat various diseases, including infectious diseases and exposure the free radicals. The part of the medicinal plant that is often used as traditional medicine is root bark of sungkai. This study explored endophytic fungi from root bark of sungkai and determined their antibacterial and antioxidant activities. Endophytic fungi were isolated from fresh root bark tissue in PDA (Potato Dextrose Agar) media and identified morphologically. The DPPH (2,2-diphenyl-1-picrylhydrazyl) and diffused-disc paper methods were used for antioxidant and antibacterial. The endophytic fungi extracts showing the best bioactivity were identified molecularly. A total of 6 isolates of endophytic fungi were found in this study (RNA1-RNA6). Antibacterial and antioxidant activity test showed the best activity for RNA4 isolates. Molecular identification results describe it as Penicillium janczewskii. This research can be used as a basic reference for isolating pure compounds that have antibacterial and antioxidant properties through chromatography techniques","PeriodicalId":16445,"journal":{"name":"Journal of Medical pharmaceutical and allied sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79297266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-30DOI: 10.55522/jmpas.v12i2.4211
V. Kahale
Currently, one of the most challenging diseases to tis breast cancer. Hormone therapy, surgery, chemotherapy, and radiation have all been used to treat breast cancer for a long time, but they are become eating less and less successful due to serious side effects and rising drug resistance. Numerous dietary foods have been linked to altered cancer genesis and progression pathways, decreased aggressiveness, and growth inhibition of malignant cells. These dietary foods may be advantageous compared to produce medications since they exhibit lower toxicity and negative effects in various investigations. The promises made by dietary foods for breast cancer treatment by focusing on several pathophysiological cascades involved in the onset and progression of breast cancer and their capacity to simultaneously stop metastatic and growth progression. Some of the extensively researched numerous dietary foods that specifically target certain breast cancer pathways and express any of the three attributes are mentioned in article.
{"title":"Understanding the prophylactic, chemo preventive, and pharmacotherapeutic perspectives of various dietary foods in breast cancer","authors":"V. Kahale","doi":"10.55522/jmpas.v12i2.4211","DOIUrl":"https://doi.org/10.55522/jmpas.v12i2.4211","url":null,"abstract":"Currently, one of the most challenging diseases to tis breast cancer. Hormone therapy, surgery, chemotherapy, and radiation have all been used to treat breast cancer for a long time, but they are become eating less and less successful due to serious side effects and rising drug resistance. Numerous dietary foods have been linked to altered cancer genesis and progression pathways, decreased aggressiveness, and growth inhibition of malignant cells. These dietary foods may be advantageous compared to produce medications since they exhibit lower toxicity and negative effects in various investigations. The promises made by dietary foods for breast cancer treatment by focusing on several pathophysiological cascades involved in the onset and progression of breast cancer and their capacity to simultaneously stop metastatic and growth progression. Some of the extensively researched numerous dietary foods that specifically target certain breast cancer pathways and express any of the three attributes are mentioned in article.","PeriodicalId":16445,"journal":{"name":"Journal of Medical pharmaceutical and allied sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74149670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-30DOI: 10.55522/jmpas.v12i2.4451
D. Venkatesh
Biological alterations result in unchecked cell growth and division producing cancer. Mankind has always been interested in light, and, it being both a topic of study and a device for looking into other occurrences can be seen following the inception of time. Besides the development of nanosystems, the usage of light has now entered a new level where interactions between light and matter occur at wavelength and subwavelength levels accompanying management by physico-chemical properties of nanoforms. This area of nanophotonics enables the investigation and control of lightencompassing nanoforms, individual molecules, and biomolecular assemblies. Numerous molecular cancer treatments have been developed using the amazing nanoscale features as a result of nanophotonics in biomolecular interactivities, or nanobiophotonics. In this work, we demonstrate the applications of nanobiophotonics and of multifaceted nanoplatforms which constitute excellent treatment efficiency and impart breakthroughs for aimed tumour treatment
{"title":"Nano-photonics in cancer therapy","authors":"D. Venkatesh","doi":"10.55522/jmpas.v12i2.4451","DOIUrl":"https://doi.org/10.55522/jmpas.v12i2.4451","url":null,"abstract":"Biological alterations result in unchecked cell growth and division producing cancer. Mankind has always been interested in light, and, it being both a topic of study and a device for looking into other occurrences can be seen following the inception of time. Besides the development of nanosystems, the usage of light has now entered a new level where interactions between light and matter occur at wavelength and subwavelength levels accompanying management by physico-chemical properties of nanoforms. This area of nanophotonics enables the investigation and control of lightencompassing nanoforms, individual molecules, and biomolecular assemblies. Numerous molecular cancer treatments have been developed using the amazing nanoscale features as a result of nanophotonics in biomolecular interactivities, or nanobiophotonics. In this work, we demonstrate the applications of nanobiophotonics and of multifaceted nanoplatforms which constitute excellent treatment efficiency and impart breakthroughs for aimed tumour treatment","PeriodicalId":16445,"journal":{"name":"Journal of Medical pharmaceutical and allied sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77559441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2023-04-30DOI: 10.55522/jmpas.v12i2.4332
G. Balasubramanian
Potentially inappropriate medications (PIMs) among geriatric are detrimental to both clinical outcomes and health care costs. Knowledge of PIMs among community pharmacists plays vital role in minimizing the inappropriate prescribing. Beers Criteria is commonly used guidelines that lists specific PIMs, where community pharmacists would benefit from knowledge of Beers Criteria in detecting PIMs in primary care. This study therefore investigates the knowledge, attitude and perception of PIMs among community pharmacists in Kedah, Malaysia. This is a prospective, cross-sectional study. The knowledge of PIMs; perception regarding PIMs; awareness of Beers Criteria; and perception of educational needs to enhance community pharmacists’ knowledge about PIMs was assessed by using 5‐point Likert scale. Descriptive statistics and Chi-square tests were used to analyse the data. In this study a total of 107 community pharmacists participated. The respondents demonstrated a higher-level knowledge of PIMs. All of the respondents agreed inappropriate medications among geriatric will cause increased in healthcare utilization, health complications and hospitalization. The respondents demonstrated poor awareness of Beers Criteria. Majority respondents were uncertain that Omeprazole is the most common Beers medication prescribed in healthcare system. Majority of respondents agreed incorporation of geriatric pharmacotherapy education as a core subject or elective subject and postgraduate education in geriatric pharmacotherapy can help to enhance community pharmacists’ knowledge about PIMs among elderly patients. The community pharmacists in Kedah demonstrated high knowledge level of PIMs but poor awareness of the Beers Criteria. Thus, there is a need to increase the awareness and use of Beers Criteria among community pharmacists.
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